keyword
MENU ▼
Read by QxMD icon Read
search

Adriamycin

keyword
https://www.readbyqxmd.com/read/29456815/crispr-cas9-a-new-approach-to-successful-knockdown-of-abcb1-p-glycoprotein-and-reversal-of-chemosensitivity-in-human-epithelial-ovarian-cancer-cell-line
#1
Leyla Norouzi-Barough, Mohammadreza Sarookhani, Rasoul Salehi, Mohammadreza Sharifi, Sahar Moghbelinejad
Objectives: Multidrug resistance (MDR) is a major obstacle in the successful chemotherapy of ovarian cancer. Inhibition of P-glycoprotein (P-gp), a member of ATP-binding cassette (ABC) transporters, is a well-known strategy to overcome MDR in cancer. The aim of this study was to investigate the efficiency and ability of CRISPR/Cas9 genome editing technology to knockdown ABCB1 gene expression in adriamycin resistant (A2780/ADR) ovarian cancer cell line and evaluate the sensitivity changes to doxorubicin...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29443738/hodgkin-lymphoma-involving-the-tonsil-misdiagnosed-as-tonsillar-carcinoma-a-case-report-and-review-of-the-literature
#2
You Qin, Lijuan Lu, Yanwei Lu, Kunyu Yang
RATIONALE: Primary Hodgkin lymphoma (HL) involving the tonsil is extremely rare. Only about 20 such cases with verification of biopsy and immunohistochemistry have been reported. Because of its rarity and unremarkable clinical presentation, a timely correct diagnosis is very challenging. PATIENT CONCERNS: A 43-year-old man complained left tonsillar enlargement and painless masses in left neck, with night sweat. The clinical examination found a marked tonsillar asymmetry, with an enlarged left tonsil and ipsilateral cervical lymphadenopathy and a normal right tonsil...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442985/enhanced-room-temperature-phosphorescence-of-mn-doped-zns-quantum-dots-composited-with-pdda-for-detection-of-adriamycin
#3
Chun-Ling Liu, Chang-Jun Hou, Dan-Qun Huo
In this work, a simple room-temperature phosphorescence (RTP) method was first proposed to detect adriamycin, by using a functional material of Mn doped ZnS quantum dots (Mn-ZnS QDs) composited with poly(diallyldimethylammonium chloride) (PDDA). After PDDA was associated to the Mn-ZnS QDs, the RTP intensity was significantly enhanced. As a result, Mn-ZnS QDs/PDDA nanoassemblies greatly improve the adriamycin detection ability of QDs and provide an important method for developing more effective and sensitive adriamycin detection sensor...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29436678/trib2-knockdown-as-a-regulator-of-chemotherapy-resistance-and-proliferation-via-the-erk-stat3-signaling-pathway-in-human-chronic-myelogenous-leukemia-k562-adm-cells
#4
Xiancheng Ma, Xue Zhou, Haiyan Qu, Ying Ma, Zhen Yue, Wenjing Shang, Pingyu Wang, Shuyang Xie, Youjie Li, Yunxiao Sun
Acquired resistance to chemotherapy plays a critical role in human drug treatment failure in many tumor types. Multidrug resistance (MDR) to Adriamycin (ADM) also limits the efficacy of therapy in human chronic myelogenous leukemia (CML). The overexpression of drug efflux transporters is one mechanism uderlying MDR. In particular, the consistent activation of MDR1 and MDR‑associated protein 1 (MRP1) is involved in drug resistance. In the present study, ADM‑resistant human CML K562/ADM cells were stably transfected with a Tribbles homolog 2 (TRIB2)‑targeted vector...
February 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29435074/over-activated-pd-1-pd-l1-axis-facilitates-the-chemoresistance-of-diffuse-large-b-cell-lymphoma-cells-to-the-chop-regimen
#5
Juan Liu, Lina Quan, Chunhui Zhang, Aichun Liu, Dongxia Tong, Jinghua Wang
Interaction between the programmed cell death ligand 1 (PD-L1) and programmed cell death 1 (PD-1) contributes to tumor cell resistance to chemotherapeutic agents. PD-L1 is expressed in the cells of diffuse large B-cell lymphoma (DLBCL), one common type of malignant non-Hodgkin lymphomas. However, little is known about how the PD-1/PD-L1 pathway functions in the pathogenesis of DLBCL. Therefore, the present study investigated whether and how the PD-1/PD-L1 axis is involved in regulating the sensitivity of CRL2631, a DLBCL cell line, to the CHOP (Cyclophosphamide, Hydroxydaunorubicin/adriamycin, Oncovin/vincristine and Prednisone) chemotherapeutic regimen...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434720/targeted-sequencing-reveals-genetic-variants-associated-with-sensitivity-of-79-human-cancer-xenografts-to-anticancer-drugs
#6
Chihiro Udagawa, Yasushi Sasaki, Hiroshi Suemizu, Yasuyuki Ohnishi, Hiroshi Ohnishi, Takashi Tokino, Hitoshi Zembutsu
Although there has been progress moving from a 'one-size-fits-all' cytotoxic approach to personalized molecular medicine, the majority of patients with cancer receive chemotherapy using cytotoxic anticancer drugs. The sequencing analysis of 409 genes associated with cancer was conducted in the present study using 59 DNA sequences extracted from human cancer xenografts implanted into nude mice, of which sensitivity to 9 cytotoxic anticancer drugs [5-fluorouracil, nimustine, adriamycin, cyclophosphamide, cisplatin, mitomycin C (MMC), methotrexate, vincristine (VCR), and vinblastine] was examined...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29425641/cardioprotection-of-sheng-mai-yin-a-classic-formula-on-adriamycin-induced-myocardial-injury-in-wistar-rats
#7
Kai Zhang, Jingyan Zhang, Xurong Wang, Lei Wang, Michela Pugliese, Annamaria Passantino, Jianxi Li
BACKGROUND: Sheng Mai Yin (SMY), a well-known Chinese herbal medicine, is widely used to treat cardiac diseases characterized by the deficiency of Qi and Yin syndrome in China. SMY-based treatment has been derived from Traditional Chinese Medicine (TCM), officially recorded in the Chinese Pharmacopoeia. PURPOSE: We aimed to clarify whether SMY attenuates myocardial injury induced by adriamycin in Wistar rats with chronic heart failure (CHF). METHODS: To quantify ginsenoside Rg1, ophiopogonin D, ophiopogonin D', schisandrin by HPLC...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29423090/efficacy-of-assessing-circulating-cell-free-dna-using-a-simple-fluorescence-assay-in-patients-with-triple-negative-breast-cancer-receiving-neoadjuvant-chemotherapy-a-prospective-observational-study
#8
Kwonoh Park, Miyoung Woo, Jeong Eun Kim, Jin-Hee Ahn, Kyung Hae Jung, Jin Roh, Gyungyub Gong, Sung-Bae Kim
This study aims to assess cell-free DNA (CFD) by a fluorescence assay as a biomarker for early prediction of a pathologic complete response (pCR) and relapse in patients with triple-negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy. Patients with clinical stage II or III TNBC scheduled for neoadjuvant chemotherapy were prospectively enrolled. All patients underwent four cycles of Adriamycin plus cyclophosphamide (AC), followed by four cycles of cisplatin or docetaxel chemotherapy and surgery...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416171/methotrexate-free-chemotherapy-and-limb-salvage-surgery-for-paediatric-osteosarcoma-in-india
#9
Reghu Kesavapillai Sukumaran, Binitha Rajeshwari, Subin Sugath, S Guruprasad Chellappan, Priyakumari Thankamony, Kusumakumary Parukuttyamma
Background: Osteosarcoma (OS) is the most common primary malignant tumor of bone. The survival of OS patients has steadily improved from <20% in the early 20th century to around 70% with current treatment. There are very few studies in pediatric OS from India analyzing various aspects of the disease. This study focuses on the clinical profile, treatment options, and their complications and survival outcomes in pediatric osteosarcoma (OS) patients. Materials and Methods: This was a retrospective observational study which included pediatric patients <14 years of age, with newly diagnosed OS confirmed by histological diagnosis...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29415482/long-chain-omega-3-polyunsaturated-fatty-acid-supplementation-protects-against-adriamycin-and-cyclophosphamide-chemotherapy-induced-bone-marrow-damage-in-female-rats
#10
Chia-Ming Fan, Yu-Wen Su, Peter R Howe, Cory J Xian
Although bone marrow and bone toxicities have been reported in breast cancer survivors, preventative strategies are yet to be developed. Clinical studies suggest consumption of long chain omega-3 polyunsaturated fatty acids (LCn3PUFA) can attenuate age-related bone loss, and recent animal studies also revealed benefits of LCn3PUFA in alleviating bone marrow and bone toxicities associated with methotrexate chemotherapy. Using a female rat model for one of the most commonly used anthracycline-containing breast cancer chemotherapy regimens (adriamycin + cyclophosphamide) (AC) chemotherapy, this study investigated potential effects of daily LCn3PUFA consumption in preserving bone marrow and bone microenvironment during chemotherapy...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29412697/mir-155-affects-osteosarcoma-mg-63-cell-autophagy-induced-by-adriamycin-through-regulating-pten-pi3k-akt-mtor-signaling-pathway
#11
Lin Wang, Bing Tang, Heng Han, Dan Mao, Jie Chen, Yun Zeng, Min Xiong
OBJECTIVE: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays a positive regulatory role on cell autophagy through inhibiting PI3K/AKT/mammalian target of rapamycin (mTOR) signaling pathway. miR-155 plays a critical role in osteosarcoma occurrence and chemoresistance. Bioinformatics analysis revealed the targeted binding site between miR-155 and the 3'-UTR (untranslated region) of PTEN mRNA. This study investigated the role of miR-155 in regulating osteosarcoma cell autophagy, chemosensitivity to Adriamycin (ADM), and PTEN-PI3K/AKT/mTOR signaling pathway...
February 7, 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29394776/-a-rare-case-of-abdominal-malignant-triton-tumor
#12
Toshihiro Ogawa, Masao Harano, Toshiaki Morito, Kouichi Ichimura, Yasuhiro Choda, Hiroyoshi Matsukawa, Yasutomo Ojima, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima
A 60-year-old woman presented at our hospital with abdominal pain and vomiting.Three abdominal tumors were detected, and she was referred to our department for surgery.She underwent an enterectomy including 2 of the tumors.The third tumor could not be resected because it had invaded the superior mesenteric artery(SMA)and superior mesenteric vein(SMV). Based on positive immunohistochemistry results for S-100 protein and desmin, nerve sheath differentiation with rhabdomyoblastic differentiation was confirmed, and she was diagnosed with a malignant triton tumor(MTT)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390927/malignant-ewing-like-neoplasm-with-an-ewsr1-klf15-fusion-at-the-crossroads-of-a-myoepithelial-carcinoma-and-a-ewing-like-sarcoma-a-case-report-with-treatment-options
#13
Todd M Stevens, Morad Qarmali, Diana Morlote, Fady M Mikhail, Jeffrey Swensen, Zoran Gatalica, Gene P Siegal, Robert M Conry
We present a case of a malignant Ewing-like neoplasm of the parotid gland in a 20-year-old woman with an EWSR1-KLF15 gene fusion that presented with pulmonary metastasis. Despite the fact that the tumor was essentially immunohistochemically negative for keratins, p63, and p40, we interpret this neoplasm as an unusual form of a high-grade myoepithelial carcinoma based on its focal plasmacytoid cytology, chondromyxoid matrix, SOX10, S100 protein, and calponin expression, and the knowledge that the EWSR1-KLF15 gene fusion has, to date, only been identified in 2 tumors, both myoepithelial carcinomas of the kidney...
January 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29390274/a-highly-malignant-case-of-neuroblastoma-with-substantial-increase-of-single-nucleotide-variants-and-normal-mismatch-repair-system-a-case-report
#14
Lin-Qing Yuan, Jin-Hu Wang, Kun Zhu, Min Yang, Wei-Zhong Gu, Can Lai, Hao-Min Li, Qiang Shu, Xi Chen
RATIONALE: Neuroblastoma is a common abdominal malignancy in children. The chemoresistant and relapsed cases have poor prognosis. The genetic background and the mechanism of resistance remain unelucidated. Next-generation sequence (NGS) is becoming a popular tool to unravel the genetic background and to guide precision medicine in oncology studies as well as in clinical practice. PATIENT CONCERNS: Here we report a neuroblastoma case of a boy aged 2 years and 8 months when first diagnosed, with multiple metastatic sites found in both lungs...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382425/-knockdown-of-dna-pkcs-inhibits-cell-cycle-and-its-mechanism-of-drug-resistant-bel7402-5-fu-hepatocellular-carcinoma-cells
#15
Dayu Li, Yun Liu, Chunbo Yu, Xiping Liu, Fang Fan
Objective To study the effect of the knock-down of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on the cell cycle of the multidrug-resistant (MDR) Bel7402/5-Fu hepatocellular carcinoma cells and its MDR mechanism. Methods After cationic liposome-mediated siDNA-PKcs oligonucleotide transfection, the drug sensitivity of Bel7402/5-Fu cells to 5-fluorouracil (5-Fu) and adriamycin (ADM) was determined by MTT assay; the cell cycle were detected by flow cytometry; meanwhile, the protein expressions of cell cycle-related proteins P21, cell cycle protein B1 (cyclin B1), cell cycle division protein 2 (CDC2) were tested by Western blotting; the expressions of ataxia telangiectasia mutated (ATM) and p53 at both mRNA and protein levels were detected by real-time PCR and Western blot analysis...
December 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29377384/paris-saponin-vii-induces-cell-cycle-arrest-and-apoptosis-by-regulating-akt-mapk-pathway-and-inhibition-of-p-glycoprotein-in-k562-adr-cells
#16
Ting Yan, Gaosheng Hu, Anhua Wang, Xianduo Sun, Xiangyong Yu, Jingming Jia
Paris saponinVII (PSVII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. We found that PSVII could inhibit the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Furthermore, the molecular mechanism underlying the cytotoxicity and downregulation of P-glycoprotein (P-gp) expression by PSVII was clarified. PSVII significantly suppressed cell proliferation by cell cycle arrest in the G0/G1 phase, which was associated with an obvious decrease in cyclin B1/D1 and CDK2/4/6 protein expression...
January 29, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29368443/barbigerone-reverses-multidrug-resistance-in-breast-mcf-7-adr-cells
#17
Xiuxia Li, Li Wan, Fang Wang, Heying Pei, Li Zheng, Wenshuang Wu, Haoyu Ye, Yanping Wang, Lijuan Chen
Development of agents to overcome multidrug resistance (MDR) is one of the important strategies in cancer chemotherapy, and P-glycoprotein (P-gp) correlates with the degree of resistance. As a naturally occurring isoflavone, whether barbigerone (BA) could reverse MDR, is unknown. In this paper, we evaluated effects of BA on reversing P-gp mediated MDR of adriamycin (ADR)-resistant human breast carcinoma (MCF-7/ADR) cells. BA (0.5 μM) treatment showed strong potency to increase ADR cytotoxicity toward MCF-7/ADR cells...
January 24, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29367724/elimination-of-stem-like-cancer-cell-side-population-by-auranofin-through-modulation-of-ros-and-glycolysis
#18
Guo-Xin Hou, Pan-Pan Liu, Shengyi Zhang, Mengqi Yang, Jianwei Liao, Jing Yang, Yumin Hu, Wen-Qi Jiang, Shijun Wen, Peng Huang
Cancer side-population (SP) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the ATP-binding cassette transporter ABCG2 involved in drug export. Auranofin (AF), a clinical drug of gold complex that is used in treatment of rheumatoid arthritis, has been reported inducing tumor antiproliferation. However, whether AF can impact SP cells remains unclear. Our study showed that AF caused a depletion of SP cells and a downregulation of stem cell markers, and impaired their ability to form tumor colonies in vitro and incidence to develop tumors in vivo of lung cancer cells...
January 24, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29364834/quercetin-suppresses-cyr61-mediated-multidrug-resistance-in-human-gastric-adenocarcinoma-ags-cells
#19
Ho Bong Hyun, Jeong Yong Moon, Somi Kim Cho
Cysteine-rich angiogenic inducer 61 (CYR61) is an extracellular matrix-associated protein involved in survival, tumorigenesis, and drug resistance. Therefore, we examined the effects of flavones against CYR61-overexpressing human gastric adenocarcinoma AGS (AGS-cyr61) cells, which show remarkable resistance to 5-fluorouracil (5-FU), adriamycin (ADR), tamoxifen (TAM), paclitaxel (PAC), and docetaxel (DOC). Among the tested flavones, quercetin had the lowest 50% inhibitory concentration (IC50) and significantly reduced the viability of AGS-cyr61 cells compared with AGS cells...
January 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29359012/hepatectomy-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus
#20
REVIEW
Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Kenji Wakayama
Despite surgical removal of tumors with portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) patients, early recurrence tends to occur, and overall survival (OS) periods remain extremely short. The role that hepatectomy may play in long-term survival for HCC with PVTT has not been established. The operative mortality of hepatectomy for HCC with PVTT has also not been reviewed. Hence, we reviewed recent literature to assess these parameters. The OS of patients who received hepatectomy in conjunction with multidisciplinary treatment tended to be superior to that of patients who did not...
December 28, 2017: World Journal of Hepatology
keyword
keyword
2811
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"