keyword
MENU ▼
Read by QxMD icon Read
search

Adriamycin

keyword
https://www.readbyqxmd.com/read/29016414/prenatal-diagnosis-of-a-melanotic-neuroectodermal-tumor-of-infancy-mnti-a-case-report-with-a-favorable-outcome-after-chemotherapy-failure-and-incomplete-resection
#1
Audrey Moreau, Louise Galmiche, Kahina Belhous, Gerald Franchi, Vincent Couloigner, Jerome Nevoux, Pierre Antoine Aymard, Arnaud Picard, Veronique Minard-Colin, Natacha Kadlub
We present the case of a woman referred to our department at 34 weeks of pregnancy with a fetal ultrasonographic scan showing a mass that had developed within the right maxilla with invasion of the orbit. A retrospective examination showed that this tumor had been present since the 12th week of pregnancy. At 39+4 weeks of gestation, a boy was born. He presented a black firm aspect in the maxilla. A computed tomographic scan and magnetic resonance imaging revealed a soft tissue swelling over the right maxilla, extending into the orbit but without invasion of the globe...
October 9, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28990091/wwc1-promotes-podocyte-survival-via-stabilizing-slit-diaphragm-protein-dendrin
#2
Ting Lin, Li Zhang, Shuangxin Liu, Yuanhan Chen, Hong Zhang, Xingchen Zhao, Ruizhao Li, Qianmei Zhang, Ruyi Liao, Zongshun Huang, Bin Zhang, Wenjian Wang, Xinling Liang, Wei Shi
Previous studies have indicated that glomerular podocyte injury serves a crucial role in proteinuria during the process of chronic kidney disease. The slit diaphragm of podocytes forms the final barrier to proteinuria. Dendrin, a constituent of the slit diaphragm protein complex, has been observed to relocate from the slit diaphragm to the nuclei in injured podocytes and promote podocyte apoptosis. However, the exact mechanism for nuclear relocation of dendrin remains unclear. The expression of WWC1 in podocyte injury induced by lipopolysaccharides (LPS) or adriamycin (ADR) was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), western blotting and the immunofluorescence assay...
October 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28987325/anti-tumor-compound-ry10-4-suppresses-multidrug-resistance-in-mcf-7-adr-cells-by-inhibiting-pi3k-akt-nf-%C3%AE%C2%BAb-signaling
#3
Xiaofan Yang, Yufeng Ding, Miao Xiao, Xin Liu, Jinlan Ruan, Pingping Xue
RY10-4, an anti-tumor agent, exerts cytotoxicity to various human cancer cell lines. However, few studies reported the effect of combined application of RY10-4 and chemotherapeutic drugs against cancer cells with multidrug resistance (MDR). In this study, P-glycoprotein (P-gp), which is reported to mediate MDR to anti-cancer drugs, was proved to be overexpressed in the adriamycin (ADR)-resistant human breast cancer cells, namely MCF-7/ADR cells. Furthermore, RY10-4 application resulted in a downregulation of P-gp in MCF-7/ADR cells, thus leading to higher chemosensitivity to ADR...
October 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28986815/effects-of-compound-zhebei-granule-combined-with-doxorubicin-on-expression-of-specific-surface-antigens-in-mice-with-transplanted-kg-1a-cells
#4
Yu Zhang, Li Hou, Xin-Yi Chen
OBJECTIVE: To investigate the effects of Compound Zhebei Granule (, CZG) combined with doxorubicin hydrochloride (adriamycin, ADM) on specific surface antigens in mice with KG-1a transplanted cells. METHODS: A subcutaneous tumor xenograft model was established by injection of the acute myeloid leukemia cell line KG-1a into the axillary flanks of BALB/c-nude mice. Twenty-four tumor bearing mice were divided into 4 groups according to a random number table, including normal saline control group, ADM group, high-dose CZG group, and mid-dose CZG group, with 6 mice in each group...
October 6, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28977957/meta-analysis-of-the-efficacy-of-treatments-for-newly-diagnosed-and-relapsed-refractory-multiple-myeloma-with-del-17p
#5
Jinghua Liu, Hui Yang, Xiaochan Liang, Yuxin Wang, Jian Hou, Yanqin Liu, Jigang Wang, Fan Zhou
We analyzed the treatment of newly diagnosed and relapsed/refractory multiple myeloma (NDMM/RRMM) patients with del(17p). Thirteen prospective studies that evaluated 3,187 MM patients, including 685with del(17p), were included in our meta-analysis. The incidence of del(17p) in NDMM and RRMM patients was similar (13% vs. 14%, respectively, P = 0.64, I(2) = 94%). The overall response rate (ORR) to new agents was 40.5% and 67.1%, respectively, in RRMM patients with or without del(17p) (P = 0.1, I(2) = 63.9%). NDMM patients with del(17p) treated with PAD (bortezomib, adriamycin, and dexamethasone) induction therapy followed by bortezomib maintenance therapy had higher progression-free survival (PFS) (25...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28973420/lrrk2-interacts-with-atm-and-regulates-mdm2-p53-cell-proliferation-axis-in-response-to-genotoxic-stress
#6
Zhongcan Chen, Zhen Cao, Wei Zhang, Minxia Gu, Zhi Dong Zhou, Baojie Li, Jing Li, Eng King Tan, Li Zeng
Pathogenic leucine-rich repeat kinase 2 (LRRK2) mutations are recognized as the most common cause of familial Parkinson's disease (PD) in certain populations. Recently, LRRK2 mutations were shown to be associated with a higher risk of hormone-related cancers. However, how LRRK2 itself contributes to cancer risk remains unknown. DNA damage causes cancer, and DNA damage responses are among the most important pathways in cancer biology. To understand the role of LRRK2 in DNA damage response pathway, we induced DNA damage by applying genotoxic stress to the cells with Adriamycin (AD)...
August 29, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28972886/paeoniflorin-ameliorates-adriamycin-induced-nephrotic-syndrome-through-the-ppar%C3%AE-angptl4-pathway-in-vivo-and-vitro
#7
Ruirui Lu, Jie Zhou, Bihao Liu, Ning Liang, Yu He, Lixia Bai, Peichun Zhang, Yanchun Zhong, Yuan Zhou, Jiuyao Zhou
Paeoniflorin (PF), an effective composition that is extracted from Radix Paeoniae Alba, plays a role in protecting against various kidney diseases. However, the mechanism of PF on nephrotic syndrome (NS) remains unclear. The aim of this study was to investigate the protective role of PF on Adriamycin (ADR)-induced NS in vivo and vitro as well as its potential mechanism. In animal study, PF significantly decreased the levels of 24-h urine protein, blood urea nitrogen, serum creatinine, total cholesterol and triglycerides in NS rats, but increased the total protein and albumin levels...
September 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28972490/phagocytosis-and-expression-of-fcg-receptors-and-cd180-on-monocytes-in-chronic-lymphocytic-leukemia
#8
T Tsertsvadze, N Mitskevich, A Bilanishvili, D Girdaladze, N Porakishvili
Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disease characterised by accumulation of monoclonal CD19+CD5+CD23+ lymphocytes in the peripheral blood and bone marrow. CLL is the most common type of the adult leukemia in the Western world. The disease is incurable, albeit there are new molecular and immunotherapy methods currently available in conjunction with chemotherapy, leading to the "precision therapy". The majority of immunotherapeutic approaches are based on the ability of therapeutic antibodies (Rituximab, Alemtuzumab) to mobilize anti-tumour potential of the Natural Killer cells and macrophages/monocytes through their Fcg-receptors (FcγR)...
September 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28964574/epigallocatechin-3-gallate-promotes-apoptosis-and-reversal-of-multidrug-resistance-in-esophageal-cancer-cells
#9
Liang Liu, Yingchao Ju, Jing Wang, Rongmiao Zhou
Evidence for demonstrating the role of the green tea component epigallocatechin-3-gallate (EGCG) in esophageal squamous cell carcinoma cells is limited. In this study, we investigated apoptosis induced by EGCG and the underlying molecular mechanisms in human esophageal squamous cell carcinoma cells. The growth-inhibitory effects of EGCG on esophageal cancer cell (Eca109 and Ec9706) were detected by MTT. Using flow cytometry, we determined the cellular apoptosis, bcl-2, bax and caspase-3 protein expression in Eca109 and Ec9706 cells following treatment with EGCG for 24h...
September 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28949388/microrna-135a-is-involved-in-podocyte-injury-in-a-transient-receptor-potential-channel-1-dependent-manner
#10
Xianggui Yang, Dongming Wu, Hongfei Du, Fang Nie, Xueli Pang, Ying Xu
Transient receptor potential (TRP) cation channels are essential for normal cellular physiology, and their abnormal expression may lead to a number of disorders, including podocytopathy. Therefore, it is crucial to understand the mechanisms underlying the regulation of TRP channels. In the present study, microRNA (miR)-135a was found to be upregulated in patients with focal segmental glomerulosclerosis and mice treated with adriamycin (ADR). In cultured podocytes, transforming growth factor (TGF)-β and ADR were found to promote miR‑135a expression...
September 25, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28948418/obesity-and-survival-in-the-neoadjuvant-breast-cancer-setting-role-of-tumor-subtype-in-an-ethnically-diverse-population
#11
Ying L Liu, Anurag Saraf, Benjamin Catanese, Shing M Lee, Yuan Zhang, Eileen P Connolly, Kevin Kalinsky
BACKGROUND: Obesity may negatively affect survival in breast cancer (BC), but studies are conflicting, and associations may vary by tumor subtypes and race/ethnicity groups. METHODS: In a retrospective review, we identified 273 women with invasive BC administered Adriamycin/Taxane-based neoadjuvant chemotherapy from 2004 to 2016 with body mass index (BMI) data at diagnosis. Obesity was defined as BMI ≥30. Associations between obesity and event-free survival (EFS), using STEEP events, and overall survival (OS), using all-cause mortality, were assessed overall and stratified by tumor subtype [[Hormone Receptor Positive (HR+)/HER2-, HER2+, and Triple-Negative Breast Cancer (TNBC])] in our diverse population...
September 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28943938/shikonin-enhances-adriamycin-antitumor-effects-by-inhibiting-efflux-pumps-in-a549-cells
#12
Xuchun Liu, Gengyun Sun
Shikonin (SHK) is a natural naphthoquinone pigment isolated from Lithospermum erythrorhizon, that has been reported to suppress the growth of a number of cancer cell types. Adriamycin (AD) is typically used as an effective anticancer agent; however, it has the propensity to induce drug resistance. The aim of the present study was to investigate the effects of SHK alone and in combination with AD on lung adenocarcinoma cells and the underlying molecular mechanisms of their effects. Colony formation, MTT and propidium iodide staining assays demonstrated that the co-treatment of A549 cells with SHK and AD significantly decreased cell viability and potently induced apoptosis...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28937297/clinical-outcome-of-patients-with-early-stage-favorable-hodgkin-lymphoma-treated-with-abvd%C3%A2-%C3%A3-%C3%A2-two-cycles-followed-by-fdg-pet-ct-restaging-and-20%C3%A2-gy-of-involved-site-radiotherapy
#13
Sophia C Kamran, Heather A Jacene, Yu-Hui Chen, Peter M Mauch, Andrea K Ng
Our purpose was to assess outcome of patients with early-stage, favorable (per GHSG criteria) Hodgkin Lymphoma (HL) staged with FDG-PET/CT and treated with two cycles of adriamycin, bleomycin, vincristine, and dacarbazine (ABVD) followed by PET/CT assessment and involved-site radiotherapy (ISRT) to 20 Gy. Records of 23 patients who met eligibility criteria, treated between 2008 and 2016, were reviewed. PET response after two cycles of ABVD was independently assessed by a nuclear medicine physician. After two cycles of ABVD, 91...
September 22, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28935820/lack-of-serum-and-glucocorticoid-inducible-kinase-3-leads-to-podocyte-dysfunction
#14
Li-Qin Peng, Hong Zhao, Song Liu, Ya-Pei Yuan, Cheng-Yan Yuan, Mercy-Julian Mwamunyi, David Pearce, Li-Jun Yao
Serum- and glucocorticoid-inducible kinase 3 (SGK3) is a downstream mediator of PI3K, which is essential for maintaining the functional integrity of podocytes. However, little is known about the role of SGK3 in podocyte function. Herein, we demonstrated that SGK3 contributes to the maintenance of podocyte integrity. Conditionally immortalized mouse podocyte cells (MPCs) were treated with puromycin aminonucleoside (PAN). PAN treatment inhibited the activity of SGK3 and the expression of podocin. Short hairpin RNA (shRNA)-mediated knockdown of SGK3 also reduced podocin expression in the absence of PAN...
September 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28932277/a-retrospective-review-of-the-multidisciplinary-management-of-medullary-thyroid-cancer-eligibility-for-systemic-therapy
#15
Georgia Geller, Janessa Laskin, Winson Y Cheung, Cheryl Ho
BACKGROUND: Medullary thyroid carcinoma (MTC) accounts for 1-2% of all thyroid cancers. The clinical course of metastatic disease can be indolent. Our aim was to characterize the natural history of disease to evaluate the true proportion of patients who would be eligible for the currently available systemic therapies. METHODS: The British Columbia Cancer Agency (BCCA) provides cancer care to a population of 4.6 million. A retrospective chart review was conducted of all patients with MTC referred to the BCCA from 1991 to 2013...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28929453/effects-of-long-term-ingestion-of-white-tea-on-oxidation-produced-by-aging-and-acute-oxidative-damage-in-rats
#16
Cristóbal Espinosa Ruiz, Lorena Cabrera, José Ángel López-Jiménez, Salvador Zamora, Francisca Pérez-Llamas
The infusion tea extracted from the leaves of the plant Camellia sinensis can be used in the prevention of cancer, cardiovascular and neurodegenerative diseases, and aging, while adriamycin (ADR) is an anticancer drug that increases oxidative stress in cells. The present study evaluated the protective effect of the long-term consumption of white tea used at two different doses against the oxidative stress produced by aging and acute oxidation caused ADR treatment. At wearing, rats received distilled water (control), or 0...
September 19, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28920928/targeting-tumor-multicellular-aggregation-through-igpr-1-inhibits-colon-cancer-growth-and-improves-chemotherapy
#17
N Woolf, B E Pearson, P A Bondzie, R D Meyer, M Lavaei, A C Belkina, V Chitalia, N Rahimi
Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis. As tumor cells lose the requirement for anchorage to ECM, they rely on cell-cell adhesion 'multicellular aggregation' for survival. Multicellular aggregation of tumor cells also significantly determines the sensitivity of tumor cells to the cytotoxic effects of chemotherapeutics. In this report, we demonstrate that expression of immunoglobulin containing and proline-rich receptor-1 (IGPR-1) is upregulated in human primary colon cancer...
September 18, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28915555/identification-of-a-p53-repressed-gene-module-in-breast-cancer-cells
#18
Takafumi Miyamoto, Chizu Tanikawa, Varalee Yodsurang, Yao-Zhong Zhang, Seiya Imoto, Rui Yamaguchi, Satoru Miyano, Hidewaki Nakagawa, Koichi Matsuda
The p53 protein is a sophisticated transcription factor that regulates dozens of target genes simultaneously in accordance with the cellular circumstances. Although considerable efforts have been made to elucidate the functions of p53-induced genes, a holistic understanding of the orchestrated signaling network repressed by p53 remains elusive. Here, we performed a systematic analysis to identify simultaneously regulated p53-repressed genes in breast cancer cells. Consequently, 28 genes were designated as the p53-repressed gene module, whose gene components were simultaneously suppressed in breast cancer cells treated with Adriamycin...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914370/thioredoxin-1-is-associated-with-the-proliferation-and-apoptosis-of-rheumatoid-arthritis-fibroblast-like-synoviocytes
#19
Tianbao Lu, Ming Zong, Shasha Fan, Ying Lu, Shanhan Yu, Lieying Fan
We aimed to investigate the possible effects of thioredoxin 1 (Trx1) on the proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and elucidate the possible mechanisms involved. We investigated the distribution and expression of Trx1 in synovial tissues from RA and osteoarthritis (OA) patients by immunohistochemistry and real-time polymerase chain reaction (RT-PCR) analyses. RA-FLSs were isolated and cultured under normoxic (21% oxygen) or hypoxic (3% oxygen) concentrations...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28911066/prevention-of-chemotherapy-toxicity-by-agents-that-neutralize-or-degrade-cell-free-chromatin
#20
I Mittra, K Pal, N Pancholi, A Shaikh, B Rane, P Tidke, S Kirolikar, N K Khare, K Agrawal, H Nagare, N K Nair
Background: Toxicity associated with chemotherapy is a major therapeutic challenge and is caused by chemotherapy-induced DNA damage and inflammation. We have recently reported that cell-free chromatin (cfCh) fragments released from dying cells can readily enter into healthy cells of the body to integrate into their genomes and induce DNA double-strand breaks, apoptosis and inflammation in them. We hypothesized that much of the toxicity of chemotherapy might be due to release of large quantities of cfCh from dying cells that could trigger an exaggerated DNA damage, apoptotic and inflammatory response in healthy cells over and above that caused by the drugs themselves...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
keyword
keyword
2811
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"