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https://www.readbyqxmd.com/read/28212576/galectin-1-knockdown-improves-drug-sensitivity-of-breast-cancer-by-reducing-p-glycoprotein-expression-through-inhibiting-the-raf-1-ap-1-signaling-pathway
#1
Fang Wang, Pengwei Lv, Yuanting Gu, Lin Li, Xin Ge, Guangcheng Guo
Galectin-1 (Gal-1), a member of the galectin family of carbohydrate binding proteins, plays a pivotal role in various cellular processes of tumorigenesis. The regulatory effect of Gal-1 on multidrug resistance (MDR) breast cancer cells is still unclear. qRT-PCR and western blot showed that Gal-1 and MDR gene 1 (MDR1) were both highly expressed in breast tumor tissues and cell lines. MTT assay and flow cytometry revealed that Gal-1 knockdown improved sensitivity to paclitaxel (PTX) and adriamycin (ADR) in MCF-7/PTX and MCF-7/ADR cells via inhibition of cell viability and promotion of cell apoptosis, while MDR1 overexpression weakened the sensitivity to PTX and ADR induced by Gal-1 knockdown...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28205183/large-primary-pleural-synovial-sarcoma-with-severe-dyspnea-a-case-report
#2
Minoru Yamaki, Shuji Yonehara, Toshio Noriyuki
BACKGROUND: Synovial sarcoma is a malignant neoplasm of soft tissues. It occurs mainly in the extremities and is closely related to tendons, tendon sheaths, and bursal structures. Primary synovial sarcoma of the pleura and lungs is extremely rare. CASE PRESENTATION: We present the case of a 62-year-old man with a large synovial sarcoma of the left pleura. He presented with general fatigue and severe dyspnea. Chest computed tomography (CT) revealed a 20-cm tumor in the left thoracic cavity...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28186963/an-oral-quinoline-derivative-mpt0b392-causes-leukemic-cells-mitotic-arrest-and-overcomes-drug-resistant-cancer-cells
#3
Min-Wu Chao, Han-Li Huang, Wei-Chun HuangFu, Kai-Cheng Hsu, Yi-Min Liu, Yi-Wen Wu, Chao-Feng Lin, Yi-Lin Chen, Mei-Jung Lai, Hsueh-Yun Lee, Jing-Ping Liou, Che-Ming Teng, Chia-Ron Yang
Despite great advances in the treatment of acute leukemia, a renaissance of current chemotherapy needs to be improved. The present study elucidates the underlying mechanism of a new synthetic quinoline derivative, MPT0B392 (B392) against acute leukemia and its potential anticancer effect in drug resistant cells. B392 caused mitotic arrest and ultimately led to apoptosis. It was further demonstrated to be a novel microtubule-depolymerizing agent. The effects of oral administration of B392 showed relative potent anti-leukemia activity in an in vivo xenograft model...
February 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28181940/stable-disease-in-a-patient-with-metastatic-leiomyosarcoma-treated-with-trabectedin
#4
Ketty Tavella, Alessandro Villanucci, Laura Vannini, Daniele Lavacchi, Silvia Montelatici, Gianni Amunni, Teresita Mazzei
Leiomyosarcomas represent the most common variant of uterine sarcomas, and are also considered to be the least chemosensitive. To date, adriamycin and ifosfamide are believed to be the most effective drugs for its treatment, in addition to docetaxel and gemcitabine. Recently, the introduction of trabectedin has provided clinicians with another treatment option, and the drug may have some benefits for patients as it may allow for long-term treatment. We present the case of a patient who previously failed multiple cycles of chemotherapy and who was subsequently treated with 30 cycles of trabectedin as third-line therapy for multiple metastases of uterine leiomyosarcoma...
February 8, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28177682/reversal-of-p-glycoprotein-medicated-multidrug-resistance-and-pharmacokinetics-study-in-rats-by-wyx-5
#5
Yuzhu Wang, Jian Cui, Yuxuan Dai, Yuxiang Wu, Wenlong Huang, Hai Qian, Liang Ge
Multidrug resistance (MDR) is one of the major obstacles confronted in cancer chemotherapy, which mainly due to the overexpression of P-glycoprotein (P-gp). Co-administration of anticancer drugs and P-gp inhibitors is a promising approach to overcome MDR. WYX-5, a novel P-gp inhibitor, shows a notable reversal effect with low cytotoxicity in vitro. In this paper, the reversal mechanism and safety of the MDR modulator WYX-5 were explored in vitro, and evaluated for its pharmacokinetics and effects on Adriamycin (ADM) metabolism <i>in vivo</i>...
December 22, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28177244/replacing-d-glucosamine-with-its-l-enantiomer-in-glycosylated-antitumor-ether-lipids-gaels-retains-cytotoxic-effects-against-epithelial-cancer-cells-and-cancer-stem-cells
#6
Makanjuola Ogunsina, Pranati Samadder, Temilolu Idowu, Gilbert Arthur, Frank M Schweizer
We describe metabolically inert L-glucosamine-based L-GAELs that retain the cytotoxic effects of the D-GAELs including the ability to kill BT-474 breast cancer stem cells (CSCs). When compared to adriamycin, cisplatin and the anti CSC agent salinomycin, L-GAELs display superior activity to kill cancer stem cells (CSCs). Mode of action studies indicate that L-GAELs like the D-GAELs kill cells via an apoptosis-independent mechanism that was not due to membranolytic effects.
February 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28165066/microrna-130b-targets-pten-to-mediate-drug-resistance-and-proliferation-of-breast-cancer-cells-via-the-pi3k-akt-signaling-pathway
#7
Yuan Miao, Wei Zheng, Nana Li, Zhen Su, Lifen Zhao, Huimin Zhou, Li Jia
Multidrug resistance (MDR) correlates with treatment failure and poor prognosis among breast cancer patients. This study was aimed to investigate the possible mechanism by which microRNA-130b-3p (miR-130b) mediates the chemoresistance and proliferation of breast cancer. MiR-130b was found to be up-regulated in tumor tissues versus adjacent tissues of breast cancer, as well as in adriamycin (ADR) resistant breast cancer cell line (MCF-7/ADR) versus its parental line (MCF-7) and the non-malignant breast epithelial cell line (MCF-10A), demonstrating its crucial relevance for breast cancer biology...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28154198/il-33-mediated-expansion-of-type-2-innate-lymphoid-cells-protects-from-progressive-glomerulosclerosis
#8
Jan-Hendrik Riedel, Martina Becker, Kerstin Kopp, Mathis Düster, Silke R Brix, Catherine Meyer-Schwesinger, Luis A Kluth, Ann-Christin Gnirck, Madena Attar, Sonja Krohn, Boris Fehse, Rolf A K Stahl, Ulf Panzer, Jan-Eric Turner
Innate lymphoid cells (ILCs) have an important role in the immune system's response to different forms of infectious and noninfectious pathologies. In particular, IL-5- and IL-13-producing type 2 ILCs (ILC2s) have been implicated in repair mechanisms that restore tissue integrity after injury. However, the presence of renal ILCs in humans has not been reported. In this study, we show that ILC populations are present in the healthy human kidney. A detailed characterization of kidney-residing ILC populations revealed that IL-33 receptor-positive ILC2s are a major ILC subtype in the kidney of humans and mice...
February 2, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28152424/epsin-3-a-novel-p53-target-regulates-the-apoptotic-pathway-and-gastric-carcinogenesis
#9
Jinichi Mori, Chizu Tanikawa, Naomi Ohnishi, Yuki Funauchi, Osamu Toyoshima, Koji Ueda, Koichi Matsuda
BACKGROUND & AIM: p53 activation by cellular stresses induces the transcription of hundreds of its target genes. To elucidate the entire picture of its downstream pathway, we screened a cDNA microarray dataset of adriamycin-treated HCT116 p53(-/-) or p53(+/+) cells and identified EPSIN 3 as a novel p53 target. METHODS: Potential p53 binding sequences in the EPSIN 3 locus were evaluated by reporter and CHIP assays. To investigate the role of EPSIN 3 in the p53 downstream pathway, we assessed DNA damage-induced apoptosis in EPSIN 3-knockdown HCT116 cells or Epsin 3-deficient mice...
January 30, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28150717/wogonin-reversed-resistant-human-myelogenous-leukemia-cells-via-inhibiting-nrf2-signaling-by-stat3-nf-%C3%AE%C2%BAb-inactivation
#10
Xuefen Xu, Xiaobo Zhang, Yi Zhang, Lin Yang, Yicheng Liu, Shaoliang Huang, Lu Lu, Lingyi Kong, Zhiyu Li, Qinglong Guo, Li Zhao
Constitutive NF-E2-related factor 2 (Nrf2, NFE2L2) activation has been recently reported to play a pivotal role in enhancing cell survival and resistance to anticancer drugs in many tumors. Wogonin had strong reversal potency via reduction of Nrf2 mRNA in Adriamycin (ADR)-induced resistant human chronic myelogenous leukemia (CML) K562/A02, but the mechanism of reduction of Nrf2 mRNA was still unclear. In this study, we aimed to delineate the mechanism by which Wogonin suppressed transcription of Nrf2 in resistant CML cells and further evaluate the reversal effects of Wogonin on the established animal models...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28146436/silence-of-cancer-susceptibility-candidate-9-inhibits-gastric-cancer-and-reverses-chemoresistance
#11
Chao Shang, Lin Sun, Jiale Zhang, Bochao Zhao, Xiuxiu Chen, Huimian Xu, Baojun Huang
Cancer Susceptibility Candidate 9 (CASC9) is a novel gene generating long non-coding RNA (lncRNA) with oncogenic potential that was first identified in esophageal cancer. In this study, we have found that CASC9 was overexpressed in gastric cancer (GC) compared to normal gastric tissue. A higher expression level was associated with aggressive pathological characteristics, including deep invasion, poor differentiation and lymph node metastases. In two gastric cancer cell lines, BGC823 and SGC7901, CASC9 were both overexpressed compared to that of normal gastric epithelial cell (GES-1)...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28126883/prognostic-value-of-bone-marrow-tracer-uptake-pattern-in-baseline-pet-scan-in-hodgkin-lymphoma-results-from-an-international-collaborative-study
#12
Colette Zwarthoed, Tarec Cristoffer El-Galaly, Maria Canepari, Matthieu John Ouvrier, Julien Viotti, Marc Ettaiche, Simonetta Viviani, Luigi Rigacci, Livio Trentin, Chiara Rusconi, Stefano Luminari, Maria Cantonetti, Silvia Bolis, Anna Borra, Jacques Darcourt, Flavia Salvi, Edyta Subocz, Joanna Tajer, Waldemar Kulikowski, Bogdan Malkowski, Jan Maciej Zaucha, Andrea Gallamini
RATIONALE: Positron Emission Tomography/Computed Tomography (PET/CT)-ascertained bone marrow involvement (BMI) constitutes the single most important reason for upstaging by PET/CT in Hodgkin lymphoma (HL). However, BMI assessment in PET/CT can be challenging. This study analysed the clinico-pathological correlations and prognostic meaning of different patterns of bone marrow (BM)-Fluorodeoxyglucose (FDG)-uptake in HL. PATIENTS AND METHODS: 180 newly diagnosed early unfavourable and advanced stage HL patients, all scanned at baseline and after 2 Adriamycin-Bleomycin-Vinblastine-Dacarbazine (ABVD) courses with FDG-PET, enrolled in two International studies aimed at assessing the role of interim PET scan in HL, were retrospectively included...
January 26, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28125064/phenylarsine-oxide-can-induce-the-arsenite-resistance-mutant-pml-protein-solubility-changes
#13
Yu Han Jiang, Ye Jia Chen, Chao Wang, Yong Fei Lan, Chang Yang, Qian Qian Wang, Liaqat Hussain, Yasen Maimaitiying, Khairul Islam, Hua Naranmandura
Arsenic trioxide (As₂O₃) has recently become one of the most effective drugs for treatment of patient with acute promyelocytic leukemia (APL), and its molecular mechanism has also been largely investigated. However, it has been reported that As₂O₃ resistant patients are frequently found in relapsed APL after consolidation therapy, which is due to the point mutations in B-box type 2 motifs of promyelocytic leukemia (PML) gene. In the present study, we for the first time establish whether organic arsenic species phenylarsine oxide (PAO) could induce the mutant PML-IV (A216V) protein solubility changes and degradation...
January 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28117134/palliative-chemotherapy-for-bladder-cancer-treatment-delivery-and-outcomes-in-the-general-population
#14
Andrew G Robinson, Xuejiao Wei, Francisco E Vera-Badillo, William J Mackillop, Christopher M Booth
BACKGROUND: Palliative chemotherapy for advanced bladder cancer is recommended in clinical practice guidelines because of the results achieved in clinical trials. However, real-world treatment and outcomes have not been well described. We report the treatment delivery and survival associated with palliative chemotherapy in routine clinical practice. MATERIALS AND METHODS: The population-based Ontario Cancer Registry was linked to electronic records of treatment to identify all patients with bladder cancer treated with palliative chemotherapy in Ontario during 1994 to 2008...
December 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28105187/atf2-translation-is-induced-under-chemotherapeutic-drug-mediated-cellular-stress-via-an-ires-dependent-mechanism-in-human-hepatic-cancer-bel7402-cells
#15
Qi Li, Wen-Qing Gao, Wen-Yan Dai, Chuang Yu, Rui-Yu Zhu, Jian Jin
Activating transcription factor (ATF) 2 is a member of the ATF/cyclic AMP-responsive element binding protein family, which exhibits both oncogenic and tumor-suppressor functions. In our preliminary experiments, it was observed that the expression of the ATF2 protein was induced following treatment with adriamycin (ADR) and paclitaxel (PTX), which may be regulated by internal ribosome entry segment (IRES)-mediated translation. By constructing a bicistronic vector containing the ATF2 5'-untranslated region (UTR), it was demonstrated that the ATF2 5'-UTR contains an IRES and maps a 30-nucleotide (nt) sequence (from nt 299 to nt ~269), which was essential for the IRES activity...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104133/liver-transplantation-for-biliary-rhabdomyosarcoma-with-liver-metastasis-report-of-one-case
#16
C-H Shen, K-R Dong, Y-F Tao, G Chen, R-D Li, Q-B Zhang, X-F Zhang, S Zheng, Z-X Wang
BACKGROUND: Liver transplantation in combination with chemotherapy in postoperative biliary rhabdomyosarcoma recurrence of children was evaluated. METHODS: An 8-year-old girl with biliary rhabdomyosarcoma underwent pancreatico-duodenectomy with postoperative vincristine (VCR), adriamycin (Act-D), and cyclophosphamide (CTX) (VAC chemotherapy) (VCR, 1 mg; Act-D, 0.7 mg; CTX, 1500 mg). Two years later, liver metastasis in the left and right lobes was found and was followed by VAC chemotherapy (CTX, 1800 mg; Act-D, 0...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28099947/short-term-efficacy-of-different-chemotherapy-regimens-in-the-treatment-of-advanced-gastric-cancer-a-network-meta-analysis
#17
Mi-Ma Duo-Ji, Ba-Sang Ci-Ren, Zi-Wen Long, Xiao-Hua Zhang, Dong-Lin Luo
OBJECTIVE: A network meta-analysis was performed to compare the short-term efficacy of different chemotherapy regimens in the treatment of advanced gastric cancer. METHODS: Randomized controlled trials of different chemotherapy regimens for advanced gastric cancer were included in this study. Network meta-analysis combined direct evidence and indirect evidence to evaluate the odds ratio and draw surface under the cumulative ranking curves of different chemotherapy regimens in advanced gastric cancer...
January 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28098907/synergistic-combination-of-ys-1-and-adriamycin-inhibits-human-renal-cancer-through-erk1-2-signaling-pathway-in%C3%A2-vitro-and-in%C3%A2-vivo
#18
Xiaowen Yu, Qingqing Yang, Sensen Lin, Shengtao Yuan, Li Sun
Adriamycin (ADM) is a principal drug for the treatment of renal cell cancer (RCC). Due to its limited response and high renal and cardiac toxicity, synergistic effects of ADM in combination with other drugs have been widely researched. In this study, we found the combination between YS-1 and ADM, performed higher anticancer activity on 786-O human RCC cells in vitro and in vivo, than that reported on its anti-angiogenesis effect compared with monotherapy of ADM. Our data showed that when combined with ADM, YS-1 promoted the sensitivity of 786-O cells to ADM...
January 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098863/effect-and-mechanism-of-resveratrol-on-drug-resistance-in-human-bladder-cancer-cells
#19
Shanshan Wang, Qian Meng, Qing Xie, Man Zhang
Multidrug resistance (MDR) is a significant barrier to the effective treatment of bladder cancer. In order to improve the management of bladder cancer, it is crucial to identify strategies that may reverse MDR. The effects of three herbal medicines, ginsenoside Rh2, (‑)‑epigallocatechin gallate (EGCG) and resveratrol (RES) on bladder cancer were determined. The effect of these three herbal medicines against the drug resistance in adriamycin (ADM)‑resistant pumc‑91 cells (pumc‑91/ADM) was assessed using the Cell Counting Kit‑8 cell proliferation assay system...
January 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28097015/co-administration-of-dexamethasone-increases-severity-and-accelerates-onset-day-of-neutropenia-in-bladder-cancer-patients-on-methotrexate-vinblastine-adriamycin-and-cisplatin-chemotherapy-a-retrospective-cohort-study
#20
Shingo Itai, Yukio Suga, Yusuke Hara, Kouji Izumi, Yuji Maeda, Yasuhide Kitagawa, Junko Ishizaki, Tsutomu Shimada, Atsushi Mizokami, Yoshimichi Sai
BACKGROUND: Bladder cancer patients receiving methotrexate, vinblastine, adriamycin and cisplatin (MVAC) chemotherapy are co-administered with dexamethasone as an anti-emetic. We examined whether or not dexamethasone affects the severity and onset day of MVAC-induced severe neutropenia. METHODS: This was a retrospective study of bladder cancer patients treated with MVAC chemotherapy with or without dexamethasone as an antiemetic at Kanazawa University Hospital during January 2005 - December 2009...
2017: Journal of Pharmaceutical Health Care and Sciences
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