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https://www.readbyqxmd.com/read/29667857/determining-risk-factors-that-increase-hospitalizations-in-patients-with-systemic-lupus-erythematosus
#1
D Li, H M Madhoun, W N Roberts, W Jarjour
Introduction Systemic lupus erythematosus (SLE) is a complex disease that is associated with significant mortality and an increased risk of hospitalization. Several validated instruments are available to measure disease activity in SLE patients. However, these instruments were not designed to screen for SLE patients at an increased risk of hospitalization. These instruments also fail to incorporate some data that are easily obtainable from electronic health records, such as the frequency of missed outpatient appointments...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29667566/us-emergency-medical-services-fellows
#2
Brian Clemency, Christian Martin-Gill, Nicole Rall, Dipesh Patel, Jeffery Myers
IntroductionThe 2015-2016 academic year was the fourth year since the Accreditation Council for Graduate Medical Education (ACGME; Chicago, Illinois USA) accredited Emergency Medical Services (EMS) fellowships, and the first year an in-training examination was given. Soon, ACGME-accredited fellowship education will be the sole path to EMS board certification when the practice pathway closes after 2019. This project aimed to describe the current class of EMS fellows at ACGME-accredited programs and their current educational opportunities to better understand current and future needs in EMS fellowship education...
April 18, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29667456/fertility-and-fertility-preservation-knowledge-awareness-and-attitudes-of-female-graduate-students
#3
Lisa C Hickman, Chelsea Fortin, Linnea Goodman, Xiaobo Liu, Rebecca Flyckt
PURPOSE: To evaluate the general knowledge of female graduate students on reproductive aging and fertility preservation options, as well as to investigate the perceptions, personal beliefs, and desires regarding fertility and preservation modalities. MATERIALS AND METHODS: A cross-sectional online survey study of female graduate students and medical trainees from academic institutions in Ohio was performed. Women were excluded if the online survey was incomplete or if they were >45 years...
April 18, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29667166/disability-differentials-in-educational-attainment-in-england-primary-and-secondary-effects
#4
Stella Chatzitheochari, Lucinda Platt
Childhood disability has been largely overlooked in social stratification and life course research. As a result, we know remarkably little about mechanisms behind well-documented disability differentials in educational outcomes. This study investigates educational transitions of disabled youth using data from the Longitudinal Study of Young People in England. We draw on social stratification literature on primary and secondary effects as well as that on stigma and labelling in order to explain disabled young people's educational outcomes...
April 17, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29666904/pseudogout-among-patients-fulfilling-a-billing-code-algorithm-for-calcium-pyrophosphate-deposition-disease
#5
Sara K Tedeschi, Daniel H Solomon, Katherine P Liao
To test the performance of a billing claims-based calcium pyrophosphate deposition disease (CPPD) algorithm for identifying pseudogout. We applied a published CPPD algorithm at an academic institution and randomly selected 100 patients for electronic medical record review for 3 phenotypes: (1) definite/probable CPPD, (2) definite/probable pseudogout; (3) definite pseudogout. Clinical data were recorded and positive predictive value (PPV) (95% CI) for each phenotype was calculated. We then modified the published algorithm to require ≥ 1 of 4 relevant terms ("pseudogout", "calcium pyrophosphate crystals", "CPPD", or "chondrocalcinosis") through automated text searching in clinical notes, and re-calculated PPVs...
April 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29665527/discovery-of-1-8-acridinedione-derivatives-as-novel-gcn5-inhibitors-via-high-throughput-screening
#6
Huan Xiong, Jie Han, Jun Wang, Wenchao Lu, Chen Wang, Yu Chen, Fulin Lian, Naixia Zhang, Yu-Chih Liu, Chenhua Zhang, Hong Ding, Hualiang Jiang, Wencong Lu, Cheng Luo, Bing Zhou
The general control nonrepressed protein 5 (GCN5) plays a crucial role in many biological processes. Dysregulation of GCN5 has been closely related to various human diseases, especially cancers. Hence, the exploitation of small molecules targeting GCN5 is essential for drug design and academic research. Based on the amplified luminescent proximity homogeneous assay screen methodology, we performed high throughput screening and discovered a novel GCN5 inhibitor DC_G16 with 1,8-acridinedione scaffold. Structure optimization led to the identification of a highly potent inhibitor, namely DC_G16-11 with the half-maximal inhibitory concentration (IC50 ) value of 6...
February 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29664932/obesity-and-unhealthy-lifestyle-associated-with-poor-executive-function-among-malaysian-adolescents
#7
Joyce Ying Hui Tee, Wan Ying Gan, Kit-Aun Tan, Yit Siew Chin
The understanding on the roles of obesity and lifestyle behaviors in predicting executive function of adolescents has been limited. Low executive function proficiency may have adverse effects on adolescents' school academic performance. This cross-sectional study aimed to examine the relationship between BMI-for-age and multiple lifestyle behaviors (operationalized as meal consumption, physical activity, and sleep quality) with executive function (operationalized as inhibition, working memory, and cognitive flexibility) on a sample of Malaysian adolescents aged between 12 and 16 years (N = 513)...
2018: PloS One
https://www.readbyqxmd.com/read/29663580/emergency-physician-interpretation-of-point-of-care-ultrasound-for-identifying-and-grading-of-hydronephrosis-in-renal-colic-compared-with-consensus-interpretation-by-emergency-radiologists
#8
Sameer A Pathan, Biswadev Mitra, Salman Mirza, Umais Momin, Zahoor Ahmed, Lubna G Andraous, Dharmesh Shukla, Mohammed Y Shariff, Magid M Makki, Tinsy T George, Saad S Khan, Stephen H Thomas, Peter A Cameron
OBJECTIVE: The ability of emergency physicians (EP) to identify hydronephrosis using point-of-care ultrasound (POCUS) has been assessed in the past using CT scans as the reference standard. We aimed to determine the ability of EP for identifying and grading of hydronephrosis on POCUS using the consensus interpretation of POCUS by emergency radiologists as the reference standard. METHODS: The study was conducted at an urban academic emergency department (ED) as a secondary analysis of previously collected ultrasound data from the EP performed POCUS-databank...
April 16, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29663182/do-reciprocal-relationships-between-academic-workload-and-self-regulated-learning-predict-medical-freshmen-s-achievement-a-longitudinal-study-on-the-educational-transition-from-secondary-school-to-medical-school
#9
Joselina Barbosa, Álvaro Silva, Maria Amélia Ferreira, Milton Severo
One of the most important factors that makes the transition from secondary school to medical school challenging is the inability to put in the study time that a medical school curriculum demands. The implementation of regulated learning is essential for students to cope with medical course environment and succeed. This study aimed to investigate the reciprocal relationships between self-regulated learning skills (SRLS) and academic workload (AW) across secondary school to medical school transition. Freshmen enrolled in medical school (N = 102) completed questionnaires at the beginning and at the end of their academic year, assessing AW (measured as study time hours and perceived workload), SRLS (planning and strategies for learning assessment, motivation and action to learning and self-directedness) and academic achievement...
April 16, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29661752/a-novel-information-retrieval-tool-to-find-hospital-care-team-members-development-and-usability-study
#10
Kyle Morawski, Craig Monsen, Sukhjit Takhar, Adam Landman
BACKGROUND: Hospital communication among members of a patient's care team is a central part of clinical workflow and consumes a large amount of a health care provider's time. Oftentimes the complexity of hospital care leads to difficulty in finding the appropriate contact, which can lead to inefficiencies and frustration. Squire is a Web-based information retrieval app created to improve the speed and efficiency in reaching the appropriate team member during the care of a hospitalized patient...
April 16, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29661634/assessing-patient-risk-of-central-line-associated-bacteremia-via-machine-learning
#11
Cole Beeler, Lana Dbeibo, Kristen Kelley, Levi Thatcher, Douglas Webb, Amadou Bah, Patrick Monahan, Nicole R Fowler, Spencer Nicol, Alisa Judy-Malcolm, Jose Azar
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) contribute to increased morbidity, length of hospital stay, and cost. Despite progress in understanding the risk factors, there remains a need to accurately predict the risk of CLABSIs and, in real time, prevent them from occurring. METHODS: A predictive model was developed using retrospective data from a large academic healthcare system. Models were developed with machine learning via construction of random forests using validated input variables...
April 13, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29661602/automated-breast-ultrasound-interpretation-times-a-reader-performance-study
#12
Ashley I Huppe, Marc F Inciardi, Mark Redick, Melissa Carroll, Jennifer Buckley, Jacqueline D Hill, Jason B Gatewood
RATIONALE AND OBJECTIVES: This study aimed to determine the average time for breast radiologists of varied experience to interpret automated breast ultrasound (ABUS) examinations. MATERIALS AND METHODS: A reader performance study was conducted on female patients, with ACR BI-RADS 4 breast density classifications of C or D, who received both an ABUS screening examination and a digital mammogram from 2013 to 2014 at an academic institution. Three faculty breast radiologists with varied levels of ABUS experience (advanced, intermediate, novice) read all ABUS examinations, with interpretation times and final impressions (categorized as "normal" or "abnormal") recorded for each examination...
April 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29661495/narcotics-reduction-quality-and-safety-in-gynecologic-oncology-surgery-in-the-first-year-of-enhanced-recovery-after-surgery-protocol-implementation
#13
Jennifer E Bergstrom, Marla E Scott, Yewande Alimi, Ting-Tai Yen, Deborah Hobson, Karime K Machado, Edward J Tanner, Amanda N Fader, Sarah M Temkin, Stephanie Wethington, Kimberly Levinson, Sam Sokolinsky, Brandyn Lau, Rebecca L Stone
OBJECTIVES: Enhanced Recovery After Surgery (ERAS) programs are mechanisms for achieving value-based improvements in surgery. This report provides a detailed analysis of the impact of an ERAS program on patient outcomes as well as quality and safety measures during implementation on a gynecologic oncology service at a major academic medical center. METHODS: A retrospective review of gynecologic oncology patients undergoing elective laparotomy during the implementation phase of an ERAS program (January 2016 through December 2016) was performed...
April 13, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29661221/practice-patterns-and-outcomes-for-patients-with-node-negative-hormone-receptor-positive-breast-cancer-and-intermediate-21-gene-recurrence-scores
#14
Jonathan Chen, Xian Wu, Paul J Christos, Silvia Formenti, Himanshu Nagar
BACKGROUND: The recommendation for chemotherapy in early-stage breast cancer patients has been refined by the 21-gene Recurrence Score. However, uncertainty remains whether patients in the Intermediate Risk category benefit from chemotherapy. METHODS: We analyzed female patients from the National Cancer Database from 2006 to 2012 who had pT1c-T2N0M0 breast cancer, were ER/PR-positive and HER2-negative, received endocrine therapy, and had a 21-gene Recurrence Score from 11 to 25...
April 16, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29661061/correlation-of-nasal-eosinophilia-and-response-after-nasal-provocation-test-in-patients-with-nonallergic-rhinitis
#15
Ki-Ik Park, Tae Young Jang, Seung-Chan Yang, Hyung Sun Hong, Young Hyo Kim
Objectives We aimed to evaluate the relationship between nasal eosinophilia and nasal hyperresponsiveness to allergen extract. Study Design Retrospective chart review. Setting Academic tertiary rhinologic practice. Subjects and Methods We performed allergy tests (skin prick test and multiple allergosorbent test) and nasal cytology for 194 patients with rhinitis symptoms (76 males and 118 females; age, 11-69 years). According to the results, they were classified into 4 groups: group A (allergic rhinitis with eosinophilia, n = 26), group B (allergic rhinitis without eosinophilia, n = 77), group C (nonallergic rhinitis with eosinophilia syndrome, n = 20), and group D (nonallergic rhinitis without eosinophilia, n = 71)...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29659165/improving-academic-performance-of-sport-and-exercise-science-undergraduate-students-in-gross-anatomy-using-a-near-peer-teaching-program
#16
Ricardo Borges Viana, Mário Hebling Campos, Douglas de Assis Teles Santos, Isabela Cristina Maioni Xavier, Rodrigo Luiz Vancini, Marília Santos Andrade, Claudio Andre Barbosa de Lira
Peer and near-peer teaching programs are common in medical undergraduate courses. However, there are no studies that have investigated the effectiveness of a near-peer teaching program on the academic performance of undergraduate students pursuing sport and exercise science coursework. This study was conducted to analyze the effectiveness of such a program for students who participated in a course on the functional anatomy of the locomotor apparatus. A total of 39 student participants were divided into two groups: students in one group voluntarily attended at least one session of a near-peer teaching program, and students in the other group attended no sessions...
April 16, 2018: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29659009/state-of-the-science-interprofessional-approaches-to-aging-dementia-and-mental-health
#17
Timothy W Farrell, Marilyn K Luptak, Katherine P Supiano, James T Pacala, Rosalind De Lisser
Interprofessional education (IPE) is essential to develop the healthcare workforce of the future. Geriatrics healthcare professionals have long championed innovations in IPE and patient care, but there is increased urgency to address challenges in aging, dementia, and geriatric mental health in America. In 2010, the Partnership for Health in Aging multidisciplinary competencies and a related position statement in the Journal of the American Geriatrics Society addressed interdisciplinary team (IDT) training in geriatrics...
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29658934/using-brain-activation-nir-heg-q-eeg-and-execution-measures-cpts-in-a-adhd-assessment-protocol
#18
Debora Areces, Marisol Cueli, Trinidad García, Paloma González-Castro, Celestino Rodríguez
Attention Deficit Hyperactivity Disorder (ADHD) is a problem that impacts academic performance and has serious consequences that result in difficulties in scholastic, social and familial contexts. One of the most common problems in the identification of this disorder relates to the apparent over diagnosis of the disorder due to the absence of global protocols for assessment. The research group of School Learning, Difficulties and Academic Performance (ADIR) from the University of Oviedo, has developed a complete protocol that suggests the existence of certain patterns of cortical activation and executive control for identifying ADHD more objectively...
April 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29658444/development-of-225ac-radiopharmaceuticals-triumf-perspectives-and-experiences
#19
A Kh Robertson, C F Ramogida, P Schaffer, V Radchenko
The development of radiopharmaceuticals containing 225Ac for targeted alpha therapy is an active area of academic and commercial research worldwide. Despite promising results from recent clinical trials, 225Ac-radiopharmaceutical development still faces significant challenges that must be overcome to realize the widespread clinical use of 225Ac. Some of these challenges include the limited availability of the isotope, the challenging chemistry required to isolate 225Ac from any co-produced isotopes, and the need for stable targeting systems with high radiolabeling yields...
April 16, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29656412/liver-doppler-findings-in-pediatric-patients-after-total-pancreatectomy-and-islet-autotransplantation
#20
Tara L Holm, Michael A Murati, Eric Hoggard, Lei Zhang, Kelly R Dietz
OBJECTIVES: This study was intended to establish normal values for velocities in the hepatic artery and portal veins in pediatric patients after total pancreatectomy and islet autotransplantation (TPIAT). METHODS: A retrospective review was performed of liver Doppler studies in pediatric patients after TPIAT over 6 years at an academic children's hospital. Doppler velocities in the liver vasculature and the hepatic artery resistive index were recorded. RESULTS: Sixty-five pediatric patients were evaluated...
April 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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