F-T Lee, L Sun, A Szabo, N Milligan, A Saini, D Chetan, J-L Hunt, C K Macgowan, L Freud, E Jaeggi, T Van Mieghem, J Kingdom, S P Miller, M Seed
OBJECTIVES: Fetuses with single ventricle physiology (SVP) exhibit reductions in fetal cerebral oxygenation with associated delays in fetal brain growth and neurodevelopmental outcomes. Maternal supplemental oxygen (MSO) has been proposed to improve fetal brain growth but current evidence on dosing, candidacy, and outcomes are limited. In this pilot study, we evaluated the safety and feasibility of continuous low-dose MSO in the setting of SVP. METHODS: This single-centre, open-label, pilot phase 1 safety and feasibility clinical trial included 25 pregnant individuals with a fetal diagnosis of SVP...
April 17, 2024: Ultrasound in Obstetrics & Gynecology