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https://www.readbyqxmd.com/read/28917273/mechanisms-and-risk-factors-of-thrombosis-in-cancer
#1
REVIEW
Anna Falanga, Laura Russo, Viola Milesi, Alfonso Vignoli
The close relationship between cancer and thrombosis is known since more than a century. Venous thromboembolism (VTE) may be the first manifestation of an occult malignancy in an otherwise healthy individual. Cancer patients commonly present with abnormalities of laboratory coagulation tests, indicating an ongoing subclinical hypercoagulable condition. The results of laboratory tests demonstrate that a process of fibrin formation and removal parallels the development of malignancy, which is of particular interest since fibrin and other clotting products are important for both thrombogenesis and tumor progression...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28916935/risk-stratification-model-lower-extremity-ultrasonography-for-hospitalized-patients-with-suspected-deep-vein-thrombosis
#2
Emily C Alper, Ivan K Ip, Patricia Balthazar, Gregory Piazza, Samuel Z Goldhaber, Carol B Benson, Ronilda Lacson, Ramin Khorasani
BACKGROUND: The Wells score for deep venous thrombosis (DVT) has a high failure rate and low efficiency among inpatients. OBJECTIVE: To create and validate an inpatient-specific risk stratification model to help assess pre-test probability of DVT in hospitalized patients. DESIGN: Prospective cohort study of hospitalized patients undergoing lower-extremity ultrasonography studies (LEUS) for suspected DVT. Demographics, physical findings, medical history, medications, hospitalization, and laboratory and imaging results were collected...
September 15, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28910348/the-effect-of-corn-trypsin-inhibitor-anti-tissue-factor-pathway-inhibitor-antibodies-and-phospholipids-on-microvesicle-associated-thrombin-generation-in-patients-with-pancreatic-cancer-and-healthy-controls
#3
Marit Hellum, Isabel Franco-Lie, Reidun Øvstebø, Truls Hauge, Carola E Henriksson
Circulating microvesicles (MVs) are suggested to be important contributors to cancer-associated thrombosis due to the presence of surface-bound procoagulant molecules like tissue factor (TF) and phosphatidylserine (PS). Pancreatic cancer is considered to be one of the most prothrombotic malignancies. The aim of this study was to describe the impact of analytical variables on MV-associated thrombin generation in patients with pancreatic cancer and in healthy controls. MVs were isolated from citrated plasma and added to pooled normal plasma (PNP)...
2017: PloS One
https://www.readbyqxmd.com/read/28902791/initial-features-of-hepatic-metastases-from-pancreatic-cancer-histological-and-radiolographical-appraisal-of-hepatic-micrometastases-detected-by-real-time-fluorescent-imaging
#4
Tomohiro Katada, Hideki Hashidate, Naoyuki Yokoyama, Natsuru Sudo, Koko Mitsuma, Tetsuya Otani
OBJECTIVE: The pathophysiology of primary-stage hepatic metastases from gastrointestinal cancers may provide clues to their formation. We investigated initial features of hepatic metastases from pancreatic cancer by examining the histologies of radiographically occult hepatic micrometastases. METHODS: We examined 133 consecutive pancreatic cancer patients with no evident hepatic metastases on preoperative imaging. An indocyanine green near-infrared camera system was used to detect hepatic metastases during surgery; preoperatively acquired images of patients were then retrospectively reviewed...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28902651/anticoagulant-therapy-for-acute-venous-thromboembolism
#5
Hilal Ermiş, Necip Ermiş
Deep vein thrombosis (DVT) and pulmonary embolism (PE) are currently defined as venous thromboembolism (VTE) since they share pathophysiological features and the treatment is similar in many respects. It has been determined that more than 90% of PE cases originate from DVT in the legs. PE, which is difficult to diagnose, has a mortality rate of 12% when untreated. The worldwide increase in obesity, cancer diseases, and average survival time also contribute to the increase in the incidence of VTE. Traditional treatment of VTE includes heparin, low-molecular-weight heparin, and warfarin...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28895098/recurrent-cerebral-attack-caused-by-thrombosis-in-the-pulmonary-vein-stump-in-a-patient-with-left-upper-lobectomy-on-anticoagulant-therapy-case-report-and-literature-review
#6
Takahito Nakano, Mayumi Inaba, Hiroyuki Kaneda
BACKGROUND: Thrombus formation in the pulmonary vein stump after pulmonary resection has recently been identified as a cause of systemic thrombosis including brain infarction. However, there is limited research focusing on the clinical course of pulmonary vein stump thrombus, and optimal treatment and prevention strategies of this important complication have not been established. CASE PRESENTATION: A 77-year-old woman was diagnosed with lung cancer of the left upper lobe, cT4N2M0, cStage IIIB...
September 11, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28894793/infiltrative-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-treated-with-a-single-high-dose-y90-radioembolization-and-subsequent-liver-transplantation-without-a-recurrence
#7
Meaghan S Dendy, Juan C Camacho, Johannes M Ludwig, Alyssa M Krasinskas, Stuart J Knechtle, Hyun S Kim
BACKGROUND: Infiltrative hepatocellular carcinoma with macrovascular invasion is a relatively rare presentation and usually fatal disease. METHODS: Both patients exceeded Milan and University of California-San Francisco (UCSF) criteria, and per Barcelona Clinic Liver Cancer group guidelines, they were enrolled in a prospective open-label radioembolization phase II trial that gave them optimized lobar doses of Yttrium-90 as solely the first-line therapy without concomitant or additional pharmacological or locoregional therapies...
September 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28894667/dual-vascular-free-anterolateral-thigh-flap
#8
Toshiaki Numajiri, Daiki Morita, Shoko Tsujiko, Hiroko Nakamura, Yoshihiro Sowa, Akihito Arai, Matsui Masahiro, Hiroshi Nakano, Shigeru Hirano
BACKGROUND: The optimum number of microvascular anastomoses for safe free tissue transfer is controversial. Although the case for 2 venous anastomoses versus 1 anastomosis has been argued, the use of an additional arterial anastomosis has not been examined in detail. METHODS: Twelve patients who underwent 2 arterial anastomoses for a free flap transfer were identified retrospectively from the medical records of patients undergoing reconstruction for head and neck cancer...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28892556/parenteral-anticoagulation-in-ambulatory-patients-with-cancer
#9
REVIEW
Elie A Akl, Lara A Kahale, Maram B Hakoum, Charbel F Matar, Francesca Sperati, Maddalena Barba, Victor E D Yosuico, Irene Terrenato, Anneliese Synnot, Holger Schünemann
BACKGROUND: Anticoagulation may improve survival in patients with cancer through a speculated anti-tumour effect, in addition to the antithrombotic effect, although may increase the risk of bleeding. OBJECTIVES: To evaluate the efficacy and safety of parenteral anticoagulants in ambulatory patients with cancer who, typically, are undergoing chemotherapy, hormonal therapy, immunotherapy or radiotherapy, but otherwise have no standard therapeutic or prophylactic indication for anticoagulation...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28885493/systematic-review-and-meta-analysis-of-posttransplant-hepatic-artery-and-biliary-complications-in-patients-treated-with-transarterial-chemoembolization-before-liver-transplantation
#10
Dimitri Sneiders, Thymen Houwen, Liset H M Pengel, Wojciech G Polak, Frank J M F Dor, Hermien Hartog
BACKGROUND: Hepatic artery complications are feared complications after liver transplantation and may compromise the biliary tract, graft and patient survival. The objective of this systematic review and meta-analysis was to compare risk of hepatic artery and biliary complications after liver transplantation in patients who underwent neoadjuvant transarterial chemoembolization (TACE) vs. no TACE. METHODS: Comprehensive searches were performed in Embase, MEDLINE OvidSP, Web of Science, Google Scholar and Cochrane databases to identify studies concerning hepatocellular cancer patients undergoing preliver transplantation TACE...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28884390/patients-treated-for-acute-vte-during-periods-of-treatment-related-thrombocytopenia-have-high-rates-of-recurrent-thrombosis-and-transfusion-related-adverse-outcomes
#11
B T Samuelson Bannow, R B Walter, T B Gernsheimer, D A Garcia
Venous thromboembolism (VTE) is a common complication of hematologic malignancies. Prolonged periods of thrombocytopenia are experienced universally by patients undergoing treatment for these diseases, yet data to guide management of anticoagulation in this setting are lacking. To obtain data on the management and outcomes of VTE in patients with thrombocytopenia related to the treatment of hematologic malignancies. This was an observational cohort study of patients experiencing VTE during periods of treatment-related thrombocytopenia over a 5-year period at the Fred Hutchinson Cancer Research Center...
September 7, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28879621/survival-analysis-of-advanced-hcc-treated-with-radioembolization-comparing-impact-of-clinical-performance-status-versus-vascular-invasion-metastases
#12
Rehan Ali, Ahmed Gabr, Nadine Abouchaleh, Ali Al Asadi, Ronald A Mora, Laura Kulik, Michael Abecassis, Ahsun Riaz, Riad Salem, Robert J Lewandowski
PURPOSE: In this study, we aim to compare the effects of prognostic indicators on survival analysis for Barcelona Clinic Liver Cancer (BCLC) C patients undergoing yttrium-90 radioembolization (Y-90). METHODS: A prospectively acquired database (2003-2017) for BCLC C hepatocellular carcinoma (HCC) patients that underwent radioembolization with Y-90 was searched. The criteria for BCLC C status (Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 1 or 2, metastases, and/or portal vein thrombosis (PVT)) were recorded...
September 6, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28876625/to-activate-or-not-to-activate-the-controversy-surrounding-tamoxifen-treatment-and-thrombosis
#13
T N Augustine, K Pather, T Dix-Peek, R Duarte
BACKGROUND: Cancer is associated with hypercoagulability, with therapies including chemotherapy, radiation therapy, surgery and hormone-therapy linked to an increased risk of thrombotic complications. Notwithstanding the contribution of other haematological processes and components, platelets are implicated in contributing to a hypercoagulable state, with breast cancer patients receiving Tamoxifen treatment at a greater risk for thrombotic complications. METHOD: MCF-7 and T47D breast cancer cells were cultured under standard conditions, followed by treatment with 2uM Tamoxifen for 24 hours and co-cultured with whole blood (WB) for 2...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28871990/transarterial-radioembolization-versus-concurrent-chemoradiation-therapy-for-locally-advanced-hepatocellular-carcinoma-a%C3%A2-propensity-score-matching-analysis
#14
Jeong Eun Song, Kyu Sik Jung, Do Young Kim, Kijun Song, Jong Yun Won, Hye Won Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Jinsil Seong, Kwang-Hyub Han
PURPOSE: It is unclear whether the efficacy and safety of concurrent chemoradiation therapy (CCRT) and transarterial radioembolization (TARE) with (90)Y are comparable in patients with locally advanced hepatocellular carcinoma. METHODS AND MATERIALS: In total, 209 treatment-naive patients with stage B or C cancer according to the Barcelona Clinic Liver Cancer classification who were treated with TARE or CCRT were analyzed. Propensity scores were calculated and matched at a 1:1 ratio for TARE versus CCRT using age, tumor size, tumor number, portal vein thrombosis, and Barcelona Clinic Liver Cancer staging...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871623/clinical-course-of-patients-with-symptomatic-isolated-superficial-vein-thrombosis-the-icaro-follow-up-study
#15
S Barco, F Pomero, M N D Di Minno, E Tamborini Permunian, A Malato, S Pasca, G Barillari, L Fenoglio, S Siragusa, G Di Minno, W Ageno, F Dentali
BACKGROUND: Studies of long-term thromboembolic complications and death following acute isolated superficial vein thrombosis (iSVT) of the lower extremities are scarce. OBJECTIVES: To investigate the course of iSVT in the setting of an observational multicenter study. METHODS: We collected longitudinal data of 411 consecutive outpatients with acute, symptomatic, objectively-diagnosed iSVT previously included in the cross-sectional ICARO study...
September 4, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28870084/comparison-between-thromboelastography-and-conventional-coagulation-tests-in-surgical-patients-with-localized-prostate-cancer
#16
Zhengwei Wang, Jing Li, Qingwei Cao, Lei Wang, Fengzhi Shan, Houyi Zhang
We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation on TEG test and 9 of whom showed hypocoagulation by routine coagulation test ( P = ...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28855077/effect-of-interleukin-1%C3%AE-inhibition-with-canakinumab-on-incident-lung-cancer-in-patients-with-atherosclerosis-exploratory-results-from-a-randomised-double-blind-placebo-controlled-trial
#17
Paul M Ridker, Jean G MacFadyen, Tom Thuren, Brendan M Everett, Peter Libby, Robert J Glynn
BACKGROUND: Inflammation in the tumour microenvironment mediated by interleukin 1β is hypothesised to have a major role in cancer invasiveness, progression, and metastases. We did an additional analysis in the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS), a randomised trial of the role of interleukin-1β inhibition in atherosclerosis, with the aim of establishing whether inhibition of a major product of the Nod-like receptor protein 3 (NLRP3) inflammasome with canakinumab might alter cancer incidence...
August 25, 2017: Lancet
https://www.readbyqxmd.com/read/28854911/d-dimer-levels-and-cerebral-infarction-in-critically-ill-cancer-patients
#18
Jeong-Am Ryu, Oh Young Bang, Geun-Ho Lee
BACKGROUND: D-dimer levels have been used in the diagnosis of a variety of thrombosis-related diseases. In this study, we evaluated whether measuring D-dimer levels can help to diagnose cerebral infarction (CI) in critically ill cancer patients. METHODS: We retrospectively evaluated all cancer patients who underwent brain magnetic resonance imaging (MRI) between March 2010 and February 2014 at the medical oncology intensive care unit (ICU) of Samsung Medical Center...
August 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28851310/prostate-cancer-specific-survival-among-warfarin-users-in-the-finnish-randomized-study-of-screening-for-prostate-cancer
#19
Pete T T Kinnunen, Teemu J Murtola, Kirsi Talala, Kimmo Taari, Teuvo L J Tammela, Anssi Auvinen
BACKGROUND: Venous thromboembolic events (VTE) are common in cancer patients and associated with higher mortality. In vivo thrombosis and anticoagulation might be involved in tumor growth and progression. We studied the association of warfarin and other anticoagulant use as antithrombotic medication and prostate cancer (PCa) death in men with the disease. METHODS: The study included 6,537 men diagnosed with PCa during 1995-2009. Information on anticoagulant use was obtained from a national reimbursement registry...
August 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28844809/-pulmonary-embolism-as-a-presentation-of-nephrotic-syndrome
#20
C Fraisse, M Nouvier, S Lainez, P Nesme, S Ernesto, G Devouassoux
BACKGROUND: Nephrotic syndrome (NS) in adults is defined by proteinuria>3g/24h or 50mg/kg/d, hypoproteinemia<60g/24h and hypoalbuminemia<30g/L. The final diagnosis is guided by the histopathology evidence when a renal biopsy is possible. The consequences of NS are multiple: high blood pressure, undernutrition, infections and a hypercoagulable state. OBSERVATION: We report the case of a patient presenting with thromboembolic disease, occurring in the absence of other thromboembolic risk factors, which revealed NS with spontaneously favorable evolution...
August 24, 2017: Revue des Maladies Respiratoires
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