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https://www.readbyqxmd.com/read/29236211/association-of-whole-blood-tacrolimus-concentrations-with-kidney-injury-in-heart-transplantation-patients
#1
Maaike A Sikma, Claudine C Hunault, Johannes H Kirkels, Marianne C Verhaar, Jozef Kesecioglu, Dylan W de Lange
BACKGROUND AND OBJECTIVES: Acute kidney injury (AKI) is frequently observed after heart transplantation and is associated with morbidity and mortality. However, many confounding factors also contribute to the development of AKI in heart transplants. We hypothesized that supratherapeutic whole-blood tacrolimus trough concentrations are associated with AKI. METHODS: In a retrospective observational cohort from April 2005 to December 2012, all adult heart transplantation patients were included...
December 13, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29234998/reduction-of-cardiopulmonary-renal-complications-with-serum-bnp-guided-volume-status-management-in-posthepatectomy-patients
#2
Sameer H Patel, Bradford J Kim, Ching-Wei D Tzeng, Yun Shin Chun, Claudius Conrad, Jean-Nicolas Vauthey, Thomas A Aloia
BACKGROUND: After hepatectomy, over- and under-resuscitations induce cardiopulmonary complications and acute kidney injury, respectively, leading to significant perioperative morbidity and mortality. Unlike serum chemistries or urine output, serum brain natriuretic peptide (BNP) levels have been shown to accurately reflect current intravascular fluid balance without influence from alterations of hormonal axes. Based on these data, this study was designed to measure the impact of a serum BNP-guided hepatobiliary fluid protocol on the incidence of posthepatectomy cardiopulmonary/renal complications...
October 11, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29234986/exertional-rhabdomyolysis-leading-to-acute-kidney-injury-when-genetic-defects-are-diagnosed-in-adult-life
#3
David Cucchiari, Irene Colombo, Ottavia Amato, Manuel Alfredo Podestà, Francesco Reggiani, Rossella Valentino, Irene Faravelli, Silvia Testolin, Maurizio Moggio, Salvatore Badalamenti
Rhabdomyolysis is a common cause of acute kidney injury (AKI) that is usually triggered by trauma. However, less common causes of rhabdomyolysis may precipitate AKI as well, possibly representing a diagnostic challenge even for the experienced nephrologist. Genetic defects of muscle metabolism represent one of these causes and can be overlooked in adults, since these diseases usually become apparent in childhood. We present here a case in which an adult patient with severe exertional rhabdomyolysis leading to AKI was finally diagnosed with a genetic defect of lipid metabolism...
December 12, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29234893/the-clinical-relevance-of-plasma-cd147-basigin-in-biopsy-proven-kidney-diseases
#4
Yoshiko Mori, Tomohiro Masuda, Tomoki Kosugi, Tomoki Yoshioka, Mayuko Hori, Hiroshi Nagaya, Kayaho Maeda, Yuka Sato, Hiroshi Kojima, Noritoshi Kato, Takuji Ishimoto, Takayuki Katsuno, Yukio Yuzawa, Kenji Kadomatsu, Shoichi Maruyama
BACKGROUND: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. METHODS: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch-Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014...
December 12, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29234381/antihyperglycemic-antidiabetic-and-antioxidant-effects-of-garcinia-pedunculata-in-rats
#5
Md Yousuf Ali, Sudip Paul, E M Tanvir, Md Sakib Hossen, Nur-E Noushin Rumpa, Moumoni Saha, Nikhil Chandra Bhoumik, Md Aminul Islam, Md Sabir Hossain, Nadia Alam, Siew Hua Gan, Md Ibrahim Khalil
The antihyperglycemic, antidiabetic, and antioxidant potentials of the methanolic extract of Garcinia pedunculata (GP) fruit in rats were investigated. The acute antihyperglycemic effect of different doses of GP was studied in normal male Wistar rats. Diabetes was induced by streptozotocin (STZ) injection in another cohort of male Wistar rats and they showed significantly higher blood glucose and glycated hemoglobin (HbA1c) levels, altered lipid profiles, and lower insulin levels compared to nondiabetic control animals...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234197/echocardiographic-and-electrocardiographic-predictors-of-adverse-outcomes-in-spontaneous-bacterial-peritonitis
#6
Mahek Shah, Soumya Patnaik, Obiora Maludum, Shantanu Patil, Toni Anne De Venecia, Vincent M Figueredo
Background: Patients with cirrhosis who develop Spontaneous Bacterial Peritonitis (SBP) suffer from cirrhotic cardiomyopathy which is characterized by impaired contractility in response to stress despite a relatively normal resting cardiac output. We hypothesized that electrocardiographic and echocardiographic information would help prognosticate patients developing SBP in addition to existing scoring systems. Methods: Cirrhotic patients admitted to Einstein Medical Center from 01/01/2005 to 6/30/2012 for SBP, and did not receive a transplant within one year, were included...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234192/impact-of-acute-kidney-injury-on-mortality-of-patients-hospitalized-for-complications-of-cirrhosis
#7
Anantha Nuthalapati, Nicholas Schluterman, Anuj Khanna, Deborah Greenberg, Paul J Thuluvath
Background/aims: The mortality of hospitalized patients for complications of cirrhosis is very high. We examined the independent predictors of mortality, particularly the impact of increments in creatinine, in 339 consecutive patients (636 admissions) who were admitted for complications of cirrhosis. Methods: Clinical characteristics, biochemical parameters including serum creatinine levels at various time intervals, and mortality data were recorded for all admissions...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234163/clarifying-the-relationship-between-metformin-acute-kidney-injury-and-lactic-acidosis
#8
Samira Bell, Enrique Soto-Pedre, Paul Connelly, Shona Livingstone, Ewan Pearson
No abstract text is available yet for this article.
December 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29234162/acute-kidney-injury-precision-perioperative-care-protects-the-kidneys
#9
Azra Bihorac, Charles E Hobson
No abstract text is available yet for this article.
December 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29234161/further-clarifying-the-relationship-between-metformin-acute-kidney-injury-and-lactic-acidosis
#10
Connie M Rhee, Kamyar Kalantar-Zadeh
No abstract text is available yet for this article.
December 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29234129/baseline-chloride-levels-are-associated-with-the-incidence-of-contrast-associated-acute-kidney-injury
#11
Hyung Jung Oh, Sungwon Kim, Jung Tak Park, Sang-Joon Kim, Seung Hyeok Han, Tae-Hyun Yoo, Dong-Ryeol Ryu, Shin-Wook Kang, Yong Eun Chung
Although hypo- and hyperchloremia have been associated with worsening renal outcomes, there has been no study that correlates hypo- and hyperchloremia and the incidence of contrast-associated acute kidney injury (CA-AKI). A total of 13,088 patients with less than 2.0 mg/dL of serum creatinine (Cr) who underwent contrast-enhanced abdominal CT (CECT) were included. Patients were divided into 3 groups based on Cl (the hypo-, normo- and hyperchloremia groups). Patients were also classified by baseline Cr (<1...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233979/extracellular-vesicles-from-human-induced-pluripotent-stem-cell-derived-mesenchymal-stromal-cells-hipsc-mscs-protect-against-renal-ischemia-reperfusion-injury-via-delivering-specificity-protein-sp1-and-transcriptional-activating-of-sphingosine-kinase-1-and
#12
Xiaodong Yuan, Dawei Li, Xiaosong Chen, Conghui Han, Longmei Xu, Tao Huang, Zhen Dong, Ming Zhang
Renal ischemia-reperfusion is a main cause of acute kidney injury (AKI), which is associated with high mortality. Here we show that extracellular vesicles (EVs) secreted from hiPSC-MSCs play a critical role in protection against renal I/R injury. hiPSC-MSCs-EVs can fuse with renal cells and deliver SP1 into target cells, subsequently active SK1 expression and increase S1P formation. Chromatin immunoprecipitation (ChIP) analyses and luciferase assay were used to confirm SP1 binds directly to the SK1 promoter region and promote promoter activity...
December 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29233907/glucagon-like-peptide-1-acutely-affects-renal-blood-flow-and-urinary-flow-rate-in-spontaneously-hypertensive-rats-despite-significantly-reduced-renal-expression-of-glp-1-receptors
#13
Jonas Ronn, Elisa P Jensen, Nicolai J Wewer Albrechtsen, Jens Juul Holst, Charlotte M Sorensen
Glucagon-like peptide-1 (GLP-1) is an incretin hormone increasing postprandial insulin release. GLP-1 also induces diuresis and natriuresis in humans and rodents. The GLP-1 receptor is extensively expressed in the renal vascular tree in normotensive rats where acute GLP-1 treatment leads to increased mean arterial pressure (MAP) and increased renal blood flow (RBF). In hypertensive animal models, GLP-1 has been reported both to increase and decrease MAP. The aim of this study was to examine expression of renal GLP-1 receptors in spontaneously hypertensive rats (SHR) and to assess the effect of acute intrarenal infusion of GLP-1...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29233773/repeated-oral-dose-toxicity-study-on-hydrolysable-tannin-rich-fraction-isolated-from-fruit-pericarps-of-terminalia-chebula-retz-in-wistar-albino-rats
#14
Sanmuga Priya Ekambaram, Senthamil Selvan Perumal, Keerthi B Babu, Durgalakshmi Rajendran
Terminalia chebula fruits are one of the richest sources of hydrolysable tannins and it is well known medicinal agent in traditional systems of medicine for treatment of various chronic ailments. In the present study, hydrolysable tannin rich fraction (HTF) was isolated from 80% hydroalcoholic extract of Terminalia chebula fruit pericarps and it was studied for acute and repeated dose oral toxicity in Wistar albino rats. HTF did not show any toxic symptoms or mortality at single dose administration of 5000 mg/kg/p...
December 9, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29232970/primary-coronary-intervention-in-octogenarians-and-nonagenarians-with-st-segment-elevation-myocardial-infarction-a-canadian-single-center-perspective
#15
Rajat Sharma, Brett Hiebert, David Cheung, Davinder S Jassal, Kunal Minhas
The proportion of individuals >80 years of age constitute an increasing proportion of patients who present with ST-segment elevation myocardial infarction (STEMI). The objective of this study is to evaluate in-hospital outcomes and 1-year survival of very elderly patients who present with an STEMI and undergo primary percutaneous coronary intervention (pPCI). Between 2009 and 2015, individuals >80 years of age (very elderly patients) with an STEMI presenting at a single tertiary Canadian care center were included in the study...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/29231780/a-priming-dose-protects-against-gold-nanoparticles-induced-proinflammatory-cytokines-mrna-expression-in-mice
#16
Khalid Elfaki Ibrahim, Amel Omer Bakhiet, Maaweya Elaeed Awadalla, Haseeb Ahmad Khan
AIM: To study the effect of priming doses of gold nanoparticles (GNPs) on proinflammatory cytokines in different organs of mice. MATERIALS & METHODS: Mice were injected with a single or two doses (priming group) of GNPs (5, 20 and 50 nm) and sacrificed after 1 or 7 days. The mRNA expressions of IL-1β, IL-6 and TNF-α were determined in liver, kidney and spleen. RESULTS: A single injection of 5 nm GNPs significantly increased the mRNA expressions of IL-1β and IL-6 in liver, which were normalized on day 7...
December 12, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29231160/oxaliplatin-induced-acute-tubulointerstitial-nephritis-two-case-reports%C3%A2
#17
You-Jung Choi, Kook-Hwan Oh, Hye-Ryun Kang, Soo-Jin Lee
Oxaliplatin is a platinum compound commonly used in the treatment of advanced colorectal cancer. This report describes two patients who had received repetitive combination chemotherapy including oxaliplatin for the treatment of metastatic colon cancer and who visited the emergency department with acute kidney injury several days after experiencing a hypersensitivity reaction to oxaliplatin. In both cases, the pathologic diagnosis was acute tubulointerstitial nephritis, and corticosteroid therapy resulted in improved renal function...
December 12, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29231123/urinary-protein-biomarkers-of-kidney-injury-in-patients-receiving-cisplatin-chemotherapy
#18
Blessy George, Melanie S Joy, Lauren M Aleksunes
Despite recent progress in the development of novel approaches to treat cancer, traditional antineoplastic drugs, such as cisplatin, remain a mainstay of regimens targeting solid tumors. Use of cisplatin is limited by acute kidney injury, which occurs in approximately 30% of patients. Current clinical measures, such as serum creatinine and estimated glomerular filtration rate, are inadequate in their ability to detect acute kidney injury, particularly when there is only a moderate degree of injury. Thus, there is an urgent need for improved diagnostic biomarkers to predict nephrotoxicity...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29230844/cyclophilin-d-promotes-tubular-cell-damage-and-the-development-of-interstitial-fibrosis-in-the-obstructed-kidney
#19
Weiping Hou, Khai G Leong, Elyce Ozols, Greg H Tesch, David J Nikolic-Paterson, Frank Y Ma
Cyclophilin D (CypD) is an important component in mitochondrial-dependent tubular cell death in acute kidney injury. However, it is not known whether CypD contributes to tubular cell damage in chronic interstitial fibrosis. We investigated this question in the unilateral ureter obstruction (UUO) model of renal interstitial fibrosis. Groups of CypD-/- and wild type (WT) mice were killed 7 or 12 days after UUO surgery. The significant tubular cell apoptosis seen in WT UUO was significantly reduced in CypD-/- UUO based on TUNEL and cleaved caspase 3 staining...
December 12, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29230707/acute-kidney-injury-after-abdominal-aortic-aneurysm-repair-current-epidemiology-and-potential-prevention
#20
Liesa Zabrocki, Frank Marquardt, Klaus Albrecht, Stefan Herget-Rosenthal
PURPOSE: Acute kidney injury (AKI) is a severe complication after infrarenal abdominal aortic aneurysm (iAAA) repair. Little data are available whether endovascular aneurysm (EVAR) or open aortic repair (OAR) differs with respect to AKI frequency and severity, consecutive development of chronic kidney disease (CKD) and potentially preventable and modifiable risk factors of AKI. PATIENTS AND METHODS: We assessed AKI rates, AKI stages and CKD applying current, complete definitions from the kidney disease improving global outcomes initiative in propensity-score-matched cohorts of all patients with elective and urgent iAAA repair at our institution from 2007 to 2011...
December 11, 2017: International Urology and Nephrology
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