Naomi Cornish, Philip Haycock, Hermann Brenner, Jane C Figueiredo, Tessel E Galesloot, Robert C Grant, Mattias Johansson, Daniela Mariosa, James McKay, Rish Pai, Andrew J Pellatt, N Jewel Samadder, Jianxin Shi, Florian Thibord, David-Alexandre Trégouët, Catherine Voegele, Chrissie Thirlwell, Andrew Mumford, Ryan Langdon
BACKGROUND: People with cancer experience high rates of venous thromboembolism (VTE). Risk of subsequent cancer is also increased in people experiencing their first VTE. The causal mechanisms underlying this association are not completely understood, and it is unknown whether VTE is itself a risk factor for cancer. METHODS: We used data from large genome-wide association study meta-analyses to perform bidirectional Mendelian randomization analyses to estimate causal associations between genetic liability to VTE and risk of 18 different cancers...
December 20, 2023: International Journal of Epidemiology