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Skeletal trauma

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https://www.readbyqxmd.com/read/28922248/maxillary-corticotomies-with-bone-to-bone-retraction-and-mandibular-segmental-osteotomy-for-correcting-an-anterior-double-protrusion
#1
Kyung A Kim, Baek-Soo Lee, Ayse Selenge Akbulut, Seong-Hun Kim, Gerald Nelson
BACKGROUNDS: This article presents maxillary corticotomies with bone-to-bone retraction and anterior segmental osteotomy (ASO) as an alternative to 2-jaw orthognathics in the bimaxilary protrusion patient with partially anchylosed maxillary anterior tooth. METHODS: The 18-year-old male, complaining of anterior protrusion, with a trauma history to the maxillary central incisor, and requesting rapid treatment, was treated with maxillary corticotomies in 2 stages and ASO in the mandible...
September 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28893682/effects-of-flavonoids-incorporated-biological-macromolecules-based-scaffolds-in-bone-tissue-engineering
#2
REVIEW
S Preethi Soundarya, V Sanjay, A Haritha Menon, S Dhivya, N Selvamurugan
Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to address the unmet need for bone augmentation, bone tissue engineering and regenerative medicine have evolved in the recent years. Bone tissue engineering harnesses novel scaffolds, stem cells and biological factors that promise enhanced and more reliable bone formation. Increasingly phytochemicals, particularly flavonoids are gaining renowned interest lately for their therapeutic potential on bone...
September 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28874604/mitochondrial-redox-signaling-enables-repair-of-injured-skeletal-muscle-cells
#3
Adam Horn, Jack H Van der Meulen, Aurelia Defour, Marshall Hogarth, Sen Chandra Sreetama, Aaron Reed, Luana Scheffer, Navdeep S Chandel, Jyoti K Jaiswal
Strain and physical trauma to mechanically active cells, such as skeletal muscle myofibers, injures their plasma membranes, and mitochondrial function is required for their repair. We found that mitochondrial function was also needed for plasma membrane repair in myoblasts as well as nonmuscle cells, which depended on mitochondrial uptake of calcium through the mitochondrial calcium uniporter (MCU). Calcium uptake transiently increased the mitochondrial production of reactive oxygen species (ROS), which locally activated the guanosine triphosphatase (GTPase) RhoA, triggering F-actin accumulation at the site of injury and facilitating membrane repair...
September 5, 2017: Science Signaling
https://www.readbyqxmd.com/read/28872531/flexion-type-supracondylar-humeral-fractures-ulnar-nerve-injury-increases-risk-of-open-reduction
#4
Kelly Flynn, Apurva S Shah, Christopher M Brusalis, Kelly Leddy, John M Flynn
BACKGROUND: The vast majority of displaced pediatric supracondylar humeral fractures can be treated successfully with closed reduction and percutaneous pinning. The need for open reduction is difficult to determine a priori and is typically due to the failure of closed reduction attempts or persistent limb ischemia. The aims of this study were to determine the prevalence of flexion-type supracondylar humeral fractures, the rate of open reduction for flexion-type fractures, and the predictive impact of ulnar nerve injury on the need for open reduction for flexion-type supracondylar humeral fractures...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28871936/xanthoma-like-skin-changes-in-an-elderly-woman-with-a-normal-lipid-profile
#5
Piotr Nockowski, Zdzisław Woźniak, Adam Reich, Joanna Maj
Dear Editor, An 83-year-old woman developed yellow-brownish infiltrates, nodules, and tumors mimicking xanthomas, mostly involving the periorbital and chest area within three months (Figure 1). She had no abnormalities in serum cholesterol or triglycerides levels. A detailed laboratory analysis revealed the presence of mild monoclonal gammopathy with a presence of immunoglobulin G (IgG) kappa light chains; however, according to hematologist consultation, it did not require medical intervention. Imaging assessment and ultrasound examination did not show any specific involvement of internal organs...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28842902/measuring-mitochondrial-substrate-utilization-in-skeletal-muscle-stem-cells
#6
C Hai Ly, James G Ryall
Skeletal muscle stem cells (MuSCs) derived from the somatic mesoderm play a critical role in successful muscle regeneration following injury and trauma. MuSCs have been found to undergo rapid changes in metabolism following a change in cell state, such as that which occurs during the transition from quiescence to an actively proliferating state. There is mounting evidence that metabolism is critically important in the regulation of quiescence, activation, and differentiation and thus the development of new techniques that aim to further probe the metabolism of MuSCs is essential...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28842895/skeletal-muscle-lysosomal-function-via-cathepsin-activity-measurement
#7
Kristyn Gumpper, Matthew Sermersheim, Michael X Zhu, Pei-Hui Lin
Muscle wasting or cachexia is commonly associated with aging and many diseases such as cancer, infection, autoimmune disorders, and trauma. Decrease in muscle mass, or muscle atrophy, is often caused by dysfunction of protein proteolytic systems, such as lysosomes, which regulate protein turnover and homeostasis. Lysosomes contain many hydrolases and proteases and, thus, represent the major organelle that control protein turnover. Recently, lysosomes have emerged as a signaling hub to integrate cellular functions of nutrient sensing and metabolism, autophagy, phagocytosis, and endocytosis, which are all related to tissue homeostasis...
August 27, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28839352/reconstruction-of-traumatic-bone-loss-using-the-induced-membrane-technique-preliminary-results-about-11-cases
#8
Noufanangue Kanfitine Kombate, Atchi Walla, Gamal Ayouba, B Moïse Bakriga, Yaovi Yannick Dellanh, Anani Grégoire Abalo, Assang Michel Dossim
INTRODUCTION: The use of Masquelet technique is a serious option to consider for biologic reconstruction of severe bone loss. Here is exposed a continuous and prospective study on bone loss management using that technique. The aims of this study were to assess epidemiology of bone loss due either to trauma or to non-unions and to give preliminary results. PATIENTS AND METHODS: It was a prospective study from April 2015 to december 2016 involving patients treated using the induced membrane technique for a diaphyseal bone defect due either to trauma or non-unions...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28833130/inducible-satellite-cell-depletion-attenuates-skeletal-muscle-regrowth-following-a-scald-burn-injury
#9
Celeste C Finnerty, Colleen F McKenna, Lauren A Cambias, Camille R Brightwell, Anesh Prasai, Ye Wang, Amina El Ayadi, David N Herndon, Oscar E Suman, Christopher S Fry
Severe burns result in profound skeletal muscle atrophy; persistent muscle atrophy and weakness are major complications that hamper recovery from burn injury. Many factors contribute to the erosion of muscle mass following burn trauma, and we have previously shown concurrent activation and apoptosis of muscle satellite cells following a burn injury in pediatric patients. To determine the necessity of satellite cells during muscle recovery following a burn injury, we utilized a genetically modified mouse model (Pax7(CreER) -DTA) that allows for the conditional depletion of satellite cells in skeletal muscle...
August 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28831951/protein-ingestion-preserves-proteasome-activity-during-intense-aseptic-inflammation-and-facilitates-skeletal-muscle-recovery-in-humans
#10
RANDOMIZED CONTROLLED TRIAL
Dimitrios Draganidis, Niki Chondrogianni, Athanasios Chatzinikolaou, Gerasimos Terzis, Leonidas G Karagounis, Apostolos Sovatzidis, Alexandra Avloniti, Maria Lefaki, Maria Protopapa, Chariklia K Deli, Konstantinos Papanikolaou, Athanasios Z Jamurtas, Ioannis G Fatouros
The ubiquitin-proteasome system (UPS) is the main cellular proteolytic system responsible for the degradation of normal and abnormal (e.g. oxidised) proteins. Under catabolic conditions characterised by chronic inflammation, the UPS is activated resulting in proteolysis, muscle wasting and impaired muscle function. Milk proteins provide sulphur-containing amino acid and have been proposed to affect muscle inflammation. However, the response of the UPS to aseptic inflammation and protein supplementation is largely unknown...
August 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28830650/basics-of-bone-metabolism-and-osteoporosis-in-common-pediatric-neuromuscular-disabilities
#11
REVIEW
Evren Yaşar, Emre Adigüzel, Mutluay Arslan, Dennis J Matthews
Bone modeling is a process that starts with fetal life and continues during adolescence. Complex factors such as hormones, nutritional and environmental factors affect this process. In addition to these factors, physical conditioning and medications that have toxic effects on bony tissue should be carefully considered in patient follow-up. Osteoporosis is a significant problem in pediatric population because of ongoing growth and development of skeletal system. Two types of osteoporosis are primary and secondary types and children with neuromuscular disabilities constitute a major group with secondary osteoporosis...
August 10, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28828063/analysis-of-pelvic-fracture-pattern-and-overall-orthopaedic-injury-burden-in-children-sustaining-pelvic-fractures-based-on-skeletal-maturity
#12
M K Shaath, K L Koury, P D Gibson, V M Lelkes, J S Hwang, J A Ippolito, M R Adams, M S Sirkin, M C Reilly
PURPOSE: The purpose of this study was to review pelvic fractures and concomitant orthopaedic injuries in children who have a patent triradiate cartilage (TRO) compared with children whose triradiate cartilage has closed (TRC). We hypothesise that these injuries will differ, leading to correlated alterations in management. PATIENTS AND METHODS: Using a database, we retrospectively reviewed patients aged below 18 years with pelvic fractures presenting to our Level 1 trauma center...
June 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28827507/presentation-coagulopathy-and-persistent-acidosis-predict-complications-in-orthopaedic-trauma-patients
#13
Benjamin R Childs, Daniel R Verhotz, Timothy A Moore, Heather A Vallier
OBJECTIVES: To evaluate the ability of measures of coagulopathy and acidosis to predict complications. We hypothesize that increased coagulopathy and acidosis over the first 60 hours of hospitalization will result in increased rates of infection and mortality. DESIGN: Prospective, observational. SETTING: Level 1 trauma center. PATIENTS: Three hundred and seventy-six skeletally mature patients with an Injury Severity Score (ISS) greater than 16 who were surgically treated for high energy fractures of the femur, pelvic ring, acetabulum, and/or spine...
August 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28826842/retinoid-roles-and-action-in-skeletal-development-and-growth-provide-the-rationale-for-an-ongoing-heterotopic-ossification-prevention-trial
#14
Maurizio Pacifici
The majority of skeletal elements develop via endochondral ossification. This process starts with formation of mesenchymal cell condensations at prescribed sites and times in the early embryo and is followed by chondrogenesis, growth plate cartilage maturation and hypertrophy, and replacement of cartilage with bone and marrow. This complex stepwise process is reactivated and recapitulated in physiologic conditions such as fracture repair, but can occur extraskeletally in pathologies including heterotopic ossification (HO), Ossification of the Posterior Longitudinal Ligament (OPLL) and Hereditary Multiple Exostoses (HME)...
August 18, 2017: Bone
https://www.readbyqxmd.com/read/28816287/-diagnostic-value-of-ct-scan-for-ao-b3-fracture-of-distal-radius
#15
S L Li, M Y Wang, Y Lu
OBJECTIVE: To determine whether 3-dimentional CT scans is able to effectively improve the detection rate of AO B3 distal radius fractures in clinics. METHODS: From Jan 2013 to Jan 2014, 30 patients with distal radius fractures were retrospectively enrolled in this study, all the patients directly visited the skeletal trauma emergency department in Beijing Jishuitan Hospital post injury and all of them accepted open reduction and internal fixation of distal radius fractures at last...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28812696/skeletal-trauma-reflects-hunting-behaviour-in-extinct-sabre-tooth-cats-and-dire-wolves
#16
Caitlin Brown, Mairin Balisi, Christopher A Shaw, Blaire Van Valkenburgh
Skeletal-injury frequency and distribution are likely to reflect hunting behaviour in predatory vertebrates and might therefore differ between species with distinct hunting modes. Two Pleistocene predators from the Rancho La Brea asphalt seeps, the sabre-tooth cat, Smilodon fatalis, and dire wolf, Canis dirus, represent ambush and pursuit predators, respectively. On the basis of a collection of over 1,900 pathological elements, the frequency of traumatic injury across skeletal elements in these two species was calculated...
April 10, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811217/regulation-and-phylogeny-of-skeletal-muscle-regeneration
#17
REVIEW
Meryem B Baghdadi, Shahragim Tajbakhsh
One of the most fascinating questions in regenerative biology is why some animals can regenerate injured structures while others cannot. Skeletal muscle has a remarkable capacity to regenerate even after repeated traumas, yet limited information is available on muscle repair mechanisms and how they have evolved. For decades, the main focus in the study of muscle regeneration was on muscle stem cells, however, their interaction with their progeny and stromal cells is only starting to emerge, and this is crucial for successful repair and re-establishment of homeostasis after injury...
August 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28810980/risk-factors-for-rhabdomyolysis-in-the-u-s-army
#18
Owen T Hill, Dennis E Scofield, Jenna Usedom, Lakmini Bulathsinhala, Craig McKinnon, Paul Kwon, Timothy Haley, Robert Carter
The standardized mortality rate of rhabdomyolysis (RM) in Active Duty U.S. Army Soldiers is considerably higher than in the civilian population. RM occurs when large amounts of intracellular contents from damaged skeletal muscle escape into circulation, leading to serious sequelae (e.g., acute renal failure, hyperkalemia, compartment syndrome). Extended physical exertion, especially in hot environments, and trauma can precipitate RM. The aim of this study was to identify RM risk factors among U.S. Active Duty Army (ADA) Soldiers...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810107/a-case-of-acute-compartment-syndrome-of-the-thigh-associated-with-repetitive-athletic-trauma
#19
Samuel Schimelpfenig, Travis Liddell, Eric Page
We present a case of acute compartment syndrome (ACS) in an athlete who sustained minimal but repetitive trauma to the thigh during a sporting event. During his evaluation, concern was raised regarding the diagnosis of ACS as a cause of his symptoms. This was confirmed by measuring the intra-compartmental pressures and he subsequently underwent successful emergent fasciotomy, eventually making a complete recovery. ACS is a potential complication of muscular-skeletal injuries from various causes, and our case is unusual as the cause was mild but repetitive trauma in an otherwise healthy athlete...
December 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28809625/microstructural-changes-of-tensor-fasciae-latae-and-gluteus-medius-muscles-following-total-hip-arthroplasty-a-prospective-trial
#20
M Pumberger, P VON Roth, B Preininger, M Mueller, C Perka, T Winkler
PURPOSE OF THE STUDY Although total hip arthroplasty (THA) is one of the most successful orthopedic operations, the soft tissue trauma towards the periarticular musculature during surgical approaches remains a critical concern. However, the actual microstructural proof of muscle trauma on the level of the myofiber due to the surgical approach has never been claimed. MATERIAL AND METHODS Patients undergoing THA were prospectively enrolled and either operated by a direct lateral (DL) or a anterolateral minimally invasive approach (ALMI)...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
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