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https://www.readbyqxmd.com/read/28436704/association-of-cat-262c-t-with-the-concentration-of-catalase-in-seminal-plasma-and-the-risk-for-male-infertility-in-algeria
#1
Nour El Houda Bousnane, Sadiq May, Mouloud Yahia, Abed Alkarem Abu Alhaija
Catalase (CAT) plays a central role in the protection of different cell types against the deleterious effects of hydrogen peroxide. In human, CAT is implicated in many physiological and pathological conditions including idiopathic male infertility. In this study we examined the association between CAT levels in seminal plasma with different sperm parameters and with CAT-262 C/T polymorphism and their risk for idiopathic male infertility in Algeria. Semen and blood samples were obtained from 111 infertile males and 104 fertile controls from the region of Eastern Algeria following informed consent...
April 24, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28434759/corrigendum-to-ecotoxicity-study-of-titania-tio2-nps-on-two-microalgae-species-scenedesmus-sp-and-chlorella-sp-ecotoxicol-environ-saf-74-5-2011-1180-1187
#2
I Mohammed Sadiq, Swayamprava Dalai, N Chandrasekaran, A Mukherjee
No abstract text is available yet for this article.
April 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28424879/drinking-water-management-and-governance-in-canada-an-innovative-plan-do-check-act-pdca-framework-for-a-safe-drinking-water-supply
#3
Ty Bereskie, Manuel J Rodriguez, Rehan Sadiq
Drinking water management in Canada is complex, with a decentralized, three-tiered governance structure responsible for safe drinking water throughout the country. The current approach has been described as fragmented, leading to governance gaps, duplication of efforts, and an absence of accountability and enforcement. Although there have been no major waterborne disease outbreaks in Canada since 2001, a lack of performance improvement, especially in small drinking water systems, is evident. The World Health Organization water safety plan approach for drinking water management represents an alternative preventative management framework to the current conventional, reactive drinking water management strategies...
April 19, 2017: Environmental Management
https://www.readbyqxmd.com/read/28423318/oligodendrocyte-nf1-controls-aberrant-notch-activation-and-regulates-myelin-structure-and-behavior
#4
Alejandro López-Juárez, Haley E Titus, Sadiq H Silbak, Joshua W Pressler, Tilat A Rizvi, Madeleine Bogard, Michael R Bennett, Georgianne Ciraolo, Michael T Williams, Charles V Vorhees, Nancy Ratner
The RASopathy neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant genetic disorders. In NF1 patients, neurological issues may result from damaged myelin, and mice with a neurofibromin gene (Nf1) mutation show white matter (WM) defects including myelin decompaction. Using mouse genetics, we find that altered Nf1 gene-dose in mature oligodendrocytes results in progressive myelin defects and behavioral abnormalities mediated by aberrant Notch activation. Blocking Notch, upstream mitogen-activated protein kinase (MAPK), or nitric oxide signaling rescues myelin defects in hemizygous Nf1 mutants, and pharmacological gamma secretase inhibition rescues aberrant behavior with no effects in wild-type (WT) mice...
April 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28417685/independent-socio-demographic-and-clinical-correlates-associated-with-the-perception-of-quality-of-life-of-women-with-postpartum-depressionin-north-central-nigeria
#5
Friday Tungchama, Christopher Piwuna, Aishatu Armiya'u, Yusufu Maigari, Francis Davou, Suwa Goar, Musa Umar, Suleiman Sadiq, Emmanuel Ojih, Richard Uwakwe
OBJECTIVE: Quality of life (QoL) is probably the most desired outcome of all health care policies and monitoring. This concept is seldom used on women in the postpartum, especially in the developing world. AIM: This study aimed at determining the independent socio-clinical variables associated with the perception of QoL of women with postpartum depression. METHODS: A two-stage cross-sectional procedure was used to recruit 550 participants, out of whom 531 participants completed the questionnaires with 116 participants found to have postpartum depression and were the studied population, in Nigeria...
April 18, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28416988/loss-of-atrial-pacing-in-a-patient-with-a-dual-chamber-permanent-pacemaker-what-is-the-mechanism
#6
Enes Elvin Gul, Usama Boles, Fariha Sadiq Ali, Hoshiar Abdollah
No abstract text is available yet for this article.
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28412474/kinetics-for-drug-discovery-an-industry-driven-effort-to-target-drug-residence-time
#7
REVIEW
Doris A Schuetz, Wilhelmus Egbertus Arnout de Witte, Yin Cheong Wong, Bernhard Knasmueller, Lars Richter, Daria B Kokh, S Kashif Sadiq, Reggie Bosma, Indira Nederpelt, Elena Segala, Marta Amaral, Dong Guo, Dorothee Andres, Victoria Georgi, Leigh A Stoddart, Steve Hill, Robert M Cooke, Chris De Graaf, Rob Leurs, Matthias Frech, Rebecca C Wade, Elizabeth Cunera Maria de Lange, Adriaan P IJzerman, Anke Müller-Fahrnow, Gerhard F Ecker
A considerable number of approved drugs show non-equilibrium binding characteristics, emphasizing the potential role of drug residence times for in vivo efficacy. Therefore, a detailed understanding of the kinetics of association and dissociation of a target-ligand complex might provide crucial insight into the molecular mechanism-of-action of a compound. This deeper understanding will help to improve decision making in drug discovery, thus leading to a better selection of interesting compounds to be profiled further...
April 12, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28402913/the-impacts-of-decision-uncertainty-on-municipal-solid-waste-management
#8
Atousa Soltani, Rehan Sadiq, Kasun Hewage
Municipal solid waste treatment options are not necessarily pragmatic if the stakeholders in the system don't mutually agree on their shares of liabilities. Stakeholders will select an option if their benefits are maximized and costs are minimized. A decision support framework is required to assess various waste treatment options and predict the optimal decision, considering multiple criteria and conflicting preferences of multiple stakeholders. Because of the inherent complexity, uncertainty is unavoidable and should be acknowledged to enhance the reliability in the decision-making process...
April 9, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28396864/molecular-mechanism-of-rheumatic-diseases-and-efficacy-of-current-therapies
#9
EDITORIAL
Sadiq Umar, Abdul M Tyagi, Anil K Singh, Abdul Haseeb
No abstract text is available yet for this article.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28393476/development-of-predisposition-injury-response-organ-failure-model-for-predicting-acute-kidney-injury-in-acute-on-chronic-liver-failure
#10
Rakhi Maiwall, Shiv Kumar Sarin, Suman Kumar, Priyanka Jain, Guresh Kumar, Ajeet Singh Bhadoria, Richard Moreau, Chandan Kumar Kedarisetty, Zaigham Abbas, Deepak Amarapurkar, Ankit Bhardwaj, Chhagan Bihari, Amna Subhan Butt, Albert Chan, Yogesh Kumar Chawla, Ashok Chowdhury, RadhaKrishan Dhiman, Abdul Kadir Dokmeci, Hasmik Ghazinyan H, Saeed Sadiq Hamid, Dong Joon Kim, Piyawat Komolmit, George K Lau, Guan Huei Lee, Laurentius A Lesmana, Mamun Al-Mahtab, Rajendra Prasad Mathur, Suman Lata Nayak, Qin Ning, Viniyendra Pamecha, Diana Alcantara-Payawal, Archana Rastogi, Salimur Rahman, Mohamed Rela, Vivek A Saraswat, Samir Shah, Gamal Shiha, Barjesh Chander Sharma, Manoj Kumar Sharma, Kapil Sharma, Soek Siam Tan, Shivendra Singh Chandel, Chitranshu Vashishtha, Zeeshan A Wani, Man-Fung Yuen, Osamu Yokosuka
BACKGROUND AND AIM: There is limited data on predictors of acute kidney injury(AKI) in ACLF. We developed a PIRO model (Predisposition, Injury, Response, Organ failure) for predicting AKI in a multi-centric cohort of ACLF patients. PATIENTS AND METHODS: Data of 2360 patients from APASL-ACLF Research Consortium (AARC) was analysed. Multivariate logistic regression model (PIRO score) was developed from a derivation cohort (n=1363) which was validated in another prospective multicentric cohort of ACLF patients (n=997) RESULTS: Factors significant for P component were serum creatinine[(≥2mg/dl)OR 4...
April 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28388685/fetuin-a-deficiency-protects-mice-from-experimental-autoimmune-encephalomyelitis-eae-and-correlates-with-altered-innate-immune-response
#11
Violaine K Harris, Lena Bell, Ruth-Anne Langan, John Tuddenham, Mark Landy, Saud A Sadiq
Fetuin-A is a biomarker of disease activity in multiple sclerosis. Our aim was to investigate whether Fetuin-A plays a direct role in the neuroinflammatory response in the mouse EAE model. Peak Fetuin-A expression in the CNS and in peripheral lymphoid tissue correlated with peak EAE disease activity. Fetuin-A-deficient mice showed reduced EAE severity associated with an accumulation of splenic monocyte and dendritic cell populations, increased IL-12p40, ASC1, and IL-1β expression, and an increase in T regulatory cells...
2017: PloS One
https://www.readbyqxmd.com/read/28378567/insights-into-the-microbial-diversity-and-community-dynamics-of-chinese-traditional-fermented-foods-from-using-high-throughput-sequencing-approaches
#12
Guo-Qing He, Tong-Jie Liu, Faizan A Sadiq, Jing-Si Gu, Guo-Hua Zhang
Chinese traditional fermented foods have a very long history dating back thousands of years and have become an indispensable part of Chinese dietary culture. A plethora of research has been conducted to unravel the composition and dynamics of microbial consortia associated with Chinese traditional fermented foods using culture-dependent as well as culture-independent methods, like different high-throughput sequencing (HTS) techniques. These HTS techniques enable us to understand the relationship between a food product and its microbes to a greater extent than ever before...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28375113/antibacterial-activity-of-crude-methanolic-extract-and-various-fractions-of-vitex-agnus-castus-and-myrsine-africana-against-clinical-isolates-of-methicillin-resistant-staphylococcus-aureus
#13
Bashir Ahmad, Nabia Hafeez, Gulshan Ara, Sadiq Azam, Shumaila Bashir, Ibrar Khan
Staphylococcus aureus is a nosocomial pathogen that resides in the soft tissues causing many diseases. The current study was conducted to determine the prevalence of Methicillin Resistant S. aureus (MRSA) in ear discharge and pus of patients and antibacterial activity of crude methanolic extract (Cr. MeOH Ext.) and various fractions of M. Africana and V. agnus castus against clinical isolates of MRSA. A total of 40 samples were collected from ear, nose and throat (ENT) outpatient department and wards of Khyber Teaching Hospital (KTH), Peshawar...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28367206/mood-changes-at-very-high-altitudes-in-pakistan
#14
Sabih Ahmad, Sadiq Hussain
OBJECTIVE: To screen out psychiatric 'cases' and find the frequency of anxiety and depression symptoms in military volunteers performing duties at very high altitudes in the Karakoram ranges of Pakistan. METHODS: This was a descriptive study lasting from Jan 2015 to June 2015, on volunteers serving at very high altitude, using General Health Questionnaire-12 (GHQ-12) and Hospital Anxiety and Depression Scale (HADS), Urdu versions. Analysis involved descriptive, inferential techniques and Bonferroni test...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28367175/analysis-of-orbital-malignancies-presenting-in-a-tertiary-care-hospital-in-pakistan
#15
Asad Aslam Khan, Suhail Sarwar, Mohammad Ali A Sadiq, Imran Ahmad, Nayab Tariq, Sibghat-Ul-Noor
OBJECTIVE: To determine the frequencies of various orbital malignancies amongst orbital lesions in patients presenting in a tertiary care hospital in Pakistan. METHODS: A retrospective analysis of 666 orbital cases with an established histopathological diagnosis of malignant tumors treated in Mayo Hospital Lahore from 1996 to 2015 (20 years). RESULTS: About 66% of the malignant tumors were primary, 25% secondary, 8% haematopoietic and 1% metastatic...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28347177/new-mechanistic-insights-into-the-motile-to-sessile-switch-in-various-bacteria-with-particular-emphasis-on-bacillus-subtilis-and-pseudomonas-aeruginosa-a-review
#16
Faizan A Sadiq, Steve Flint, Yun Li, TongJie Liu, Yuan Lei, Hafiz Arbab Sakandar, GuoQing He
A biofilm is a complex assemblage of microbial communities adhered to a biotic or an abiotic surface which is embedded within a self-produced matrix of extracellular polymeric substances. Many transcriptional regulators play a role in triggering a motile-sessile switch and in consequently producing the biofilm matrix. This review is aimed at highlighting the role of two nucleotide signaling molecules (c-di-GMP and c-di-AMP), toxin antitoxin modules and a novel transcriptional regulator BolA in biofilm formation in various bacteria...
April 2017: Biofouling
https://www.readbyqxmd.com/read/28321346/a-perplexing-case-of-abdominal-pain-that-led-to-the-diagnosis-of-zollinger-ellison-syndrome
#17
Adrienne Lenhart, Mona Hassan, Alireza Meighani, Omar Sadiq, Yousuf Siddiqui
Zollinger-Ellison syndrome (ZES) is a rare clinical disorder, characterized by hypersecretion of gastric acid and multiple ulcers distal to the duodenal bulb. This occurs via the release of gastrin by neuroendocrine tumors known as gastrinomas. Patients with ZES present with nonspecific GI symptoms, which often leads to a delay in diagnosis. Our patient is a 55-year-old female with chronic abdominal pain, nausea, and diarrhea. She underwent EGD, EUS, MRCP, CT scans, and cholecystectomy, which did not reveal the cause of her symptoms...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28317814/the-medicinal-plants-in-the-control-of-tuberculosis-laboratory-study-on-medicinal-plants-from-the-northern-area-of-pakistan
#18
Sami Ullah, Shah Hussain, Sadiq Noor Khan, Mohammad Khurram, Iqbal Khan, Murad Ali Khan
BACKGROUND: Tuberculosis (TB) ranks as the second leading cause of deaths due to infectious diseases. Although global efforts have been made to control TB, still, this is a serious threat as Mycobacterium tuberculosis (MTB) produced resistance against both the first- and second-line drugs. The increasing incidence of multidrug-resistant, extremely drug resistant, and totally drug-resistant TB worldwide requires extra efforts to search for new anti-TB drugs. MATERIALS AND METHODS: The present study evaluated the antimycobacterial activities of Citrullus colocynthis, Calotropis procera, Ricinus communis, Capparis decidua, and Fagonia cretica plants' extracts against rifampicin-sensitive (H37Rv) and rifampicin-resistant (TMC331) strains of MTB...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28315811/variant-two-stage-ileal-pouch-anal-anastomosis-an-innovative-and-effective-alternative-to-standard-resection-in-ulcerative-colitis
#19
Jennifer Samples, Krista Evans, Nicole Chaumont, Paula Strassle, Timothy Sadiq, Mark Koruda
BACKGROUND: Ulcerative colitis patients have been historically treated with standard single, two and three stage operative approaches. We perform a variant two-stage procedure beginning with total abdominal colectomy and end ileostomy followed by completion proctectomy and ileal pouch-anal anastomosis without a diverting loop ileostomy. The present study evaluates the effectiveness of this innovative alternative. STUDY DESIGN: Patients with ulcerative colitis admitted to UNC Hospital between 2003 and 2010 for IPAA were eligible for inclusion...
January 28, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28292373/attempted-suicide-and-seriousness-of-intent
#20
Tabassum Alvi, Saba Yasein, Sadiq Hussain, Ahmad Farjam, Muhammad Azhar, Fatima Assad
This descriptive research was conducted to estimate the method of suicide and suicidal intent among hospitalised suicide attempters at Pakistan Ordinance Factory (POF) Hospital, Wah Cantt, from December 2012 to June 2013. Data were collected from 49 hospitalised suicide attempters through purposive sampling technique by using Suicidal Intent Scale. Majority of suicide attempters (92%) used self-poisoning as the method of suicide regardless of their gender, age, occupation, past medical history, past psychiatric history, and history of suicide and psychiatric illness in their families...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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