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Jo Gibbs, Catherine R H Aicken, Lorna J Sutcliffe, Voula Gkatzidou, Laura J Tickle, Kate Hone, S Tariq Sadiq, Pam Sonnenberg, Claudia S Estcourt
OBJECTIVES: Evidence on optimal methods for providing STI test results is lacking. We evaluated an online results service, developed as part of an eSexual Health Clinic (eSHC). METHODS: We evaluated the online results service using a mixed-methods approach within large exploratory studies of the eSHC. Participants were chlamydia- positive and negative users of online postal self-sampling services in six National Chlamydia Screening Programme (NCSP) areas and chlamydia-positive patients from two genitourinary medicine (GUM) clinics between 21 July 2014 and 13 March 2015...
January 11, 2018: Sexually Transmitted Infections
Michael Nurmohamed, Ernest Choy, Sadiq Lula, Blerina Kola, Ryan DeMasi, Paola Accossato
INTRODUCTION: Rheumatic diseases are autoimmune, inflammatory diseases often associated with cardiovascular (CV) disease, a major cause of mortality in these patients. In recent years, treatment with biologic and targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs), either as monotherapy or in combination with other drugs, have become the standard of treatment. In this systematic literature review, we evaluated the effect of treatment with biologic or tofacitinib on the CV risk and outcomes in these patients...
January 9, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Noa Krugliak Cleveland, Dezheng Huo, Farah Sadiq, M Anthony Sofia, Julia Marks, Russell D Cohen, Stephen B Hanauer, Jerrold Turner, John Hart, David T Rubin
BACKGROUND: When colon polyps are removed in the setting of inflammatory bowel disease (IBD) involving the large intestine, biopsies of the flat mucosa surrounding such polyps have been recommended, but there are no data to support this practice. METHODS: We reviewed endoscopic and pathologic findings in IBD patients who had dysplastic polyps removed as well as biopsies of the adjacent flat mucosa. We assessed risk for subsequent neoplasia based on the presence or absence of dysplasia in the peri-polyp flat mucosa, and based on number and grade of index polypoid lesions...
January 4, 2018: Gastrointestinal Endoscopy
Sameen Bin Naeem, Farheen Niazi, Atif Baig, Hina Sadiq, Mubbasher Sattar
Primary CNS (central nervous system) lymphoma is a rare condition with the incidence of less than 1% of all non-Hodgkin lymphomas (NHLs) and approximately 2% of all primary brain tumours. Diagnosis can be challenging and necessitates brain biopsy for definitive diagnosis. A 41-year male presented with history of impaired cognition, facial asymmetry, visual impairment and left sided body weakness. MRI brain demonstrated multiple enhancing lesions with one larger lesion in right basal ganglia with surrounding oedema and mass effect...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Alina Haines, Andrew Brown, Syed Fahad Javaid, Fayyaz Khan, Steve Noblett, Oladipupo Omodunbi, Khurram Sadiq, Wahid Zaman, Richard Whittington
Violence risk assessment and management are key tasks in mental health services and should be guided by validated instruments covering both risk and protective factors. This article is part of an international effort to validate the Structured Assessment of Protective Factors (SAPROF) for violence. The SAPROF, Historical, Clinical, Risk Management-20 (HCR-20) and the Psychopathy Checklist-Screening Version (PCL-SV) were administered in a sample of 261 patients in U.K. forensic, general inpatient, and community mental health settings...
December 1, 2017: International Journal of Offender Therapy and Comparative Criminology
Sajid Soofi, Gul Nawaz Khan, Kamran Sadiq, Shabina Ariff, Atif Habib, Sumra Kureishy, Imtiaz Hussain, Muhammad Umer, Zamir Suhag, Arjumand Rizvi, Zulfiqar Bhutta
OBJECTIVE: To determine the prevalence and possible factors associated with anaemia, and vitamin B12 and folate deficiencies in women of reproductive age (WRA) in Pakistan. METHODS: A secondary analysis was conducted on data collected through the large-scale National Nutrition Survey in Pakistan in 2011. Anaemia was defined as haemoglobin levels <12 g/dL, vitamin B12 deficiency as serum vitamin B12 levels of <203 pg/mL (150 pmol/L) and folate deficiency as serum folate levels <4 ng/mL (10 nmol/L)...
December 22, 2017: BMJ Open
Waqas Ahmad, Ahmed Waqas, Haider Ali Saleem, Sadiq Naveed
OBJECTIVE: This data set was compiled to assess mental well-being, dietary pattern and physical health parameters of health care professionals in Pakistan. DATA DESCRIPTION: The Warwick-Edinburgh mental well-being scale was first evaluated for the Pakistani population then used, along with other measures like body mass index, exercise and dietary habits to assess health and wellbeing of health care providers. The importance of the data lies in the fact that no previous records or data exists in our knowledge that used a subjective index to assess wellbeing in Pakistani population...
December 19, 2017: BMC Research Notes
Jon Sperry, Ning Yan, Alejandro Sadiq, Xi Chen
A shell biorefinery would involve fractionation of crustacean shells and incorporation of the components into value-added products, particularly those that contain nitrogen. In a proof-of-concept study that validates this concept, the anti-cancer alkaloid proximicin A has been synthesized from the chitin-derived platform chemical 3-acetamido-5-acetylfuran (3A5AF). This study accentuates the leading role chitin is likely to play in the sustainable production of nitrogen-containing fine chemicals that are not directly attainable from lignocellulose...
December 16, 2017: ChemSusChem
Jane Caldwell, Lorne Gula, Fariha Sadiq Ali, Rodrigo I Miranda, Hoshiar Abdollah, Adrian Baranchuk, Kevin Michael, Christopher Simpson, Damian P Redfearn
BACKGROUND: Despite improving algorithms, inappropriate shocks for supraventricular arrhythmias (SVT) still occur in a significant number of patients with implantable cardioverter defibrillators (ICD). This makes the discovery of novel discriminators that use existing ICD hardware, an attractive proposition. OBJECTIVE: We hypothesised that the delay of activation onset from the device detected, far field electrogram(EGM) to the near field, bipole EGM would allow differentiation of ventricular tachycardias (VT) from SVTs...
December 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Asma Hallab, Sadiq Naveed, Ahmed Altibi, Mariam Abdelkhalek, Huyen Thi Ngo, Thao Phuong Le, Kenji Hirayama, Nguyen Tien Huy
OBJECTIVE: In this systematic review, we reviewed the association between Antiphospholipid antibody syndrome (APS) and psychosis and focused on the prevalence, clinical presentation, immunologic and neurological workup, treatment options, and clinical outcomes. METHODOLOGY: We performed this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)'s guidelines. We searched eight databases for potential articles and manually searched references and relevant articles of included studies...
November 16, 2017: General Hospital Psychiatry
Ashwaq Shakir Al-Abboodi, Abdullah Rasedee, Ahmad Bustamam Abdul, Yun Hin Taufiq-Yap, Wafaa Abd Alwahed Alkaby, Mostafa Saddam Ghaji, Peter M Waziri, Mothanna Sadiq Al-Qubaisi
Introduction: Dentatin (DEN) (5-methoxy-2, 2-dimethyl-10-(1, 1-dimethyl-2propenyl) dipyran-2-one), a natural compound present in the roots of Clausena excavata Burm f, possesses pro-apoptotic and antiproliferative effects in various cancer cells. Because of its hydrophobicity, it is believed that its complexation with hydroxy-β-cyclodextrin (HPβCD) will make it a potent inhibitor of cancer cell growth. In the current work, the molecular mechanisms of apoptosis induced by DEN and DEN-HPβCD complex were demonstrated in human colon HT-29 cancer cells...
2017: Drug Design, Development and Therapy
Sadiq Setiniyaz, Seong Hee Park, Hyun Woo Kim, Nikolay A Vinokurov, Kyu-Ha Jang, Kitae Lee, In Hyung Baek, Young Uk Jeong
We describe a compact THz-pump and X-ray-probe beamline, based on an electron linac, for ultrafast time-resolved diffraction applications. Two high-energy electron (γ > 50) bunches, 5 ns apart, impinge upon a single-foil or multifoil radiator and generate THz radiation and X-rays simultaneously. The THz pulse from the first bunch is synchronized to the X-ray beam of the second bunch by using an adjustable optical delay of a THz pulse. The peak power of THz radiation from the multifoil radiator is estimated to be 0...
November 2017: Review of Scientific Instruments
Muhammad Sadiq, Iftikhar Ahmad, Jamila Shuja, Zubair Ahmad, Riyasat Ahmed, Khushnaseeb Ahmad
Astroblastoma is an uncommon glial tumor with predominant manifestation in the young age. Herein, we report a case of 18-year-old astroblastoma female patient who presented with history of two months headache. Magnetic resonance imaging (MRI) of the brain demonstrated well circumscribed, intra-axial abnormal signal intensity lesion (size=5×4 cm2) in the right parieto-occipital region of the brain. The patient underwent complete surgical resection of the gross tumor, as confirmed by an early post-surgical MRI (i...
October 2017: Brain Tumor Research and Treatment
Sadiq Hussain, Mehwish Batool Mir, Sabih Ahmad
OBJECTIVE: To assess and compare mental health of cardiac patients with disease-free individuals. METHODS: This cross-sectional study was carried out at the Combined Military Hospital, Gilgit-Baltistan, Pakistan, from August to December 2016, and comprised cardiac patients in group A and healthy controls in group B. Data was collected using mental health inventory, a 38-item tool to measure general psychological distress and well-being. Cardiac patients' mental health was compared with illness-free individuals by applying descriptive and inferential statistical techniques...
November 2017: JPMA. the Journal of the Pakistan Medical Association
Muhammad Imran, Farhat Ullah, Muhammad Ayaz, Abdul Sadiq, Muhammad Raza Shah, Muhammad Saeed Jan, Farman Ullah
BACKGROUND: Nonea micrantha Boiss. & Reut . being an unexplored member of Boraginaceae was investigated for GC/MS analysis, acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory and antioxidant activities in an attempt to find its effectiveness in neurological disorders. METHODS: The AChE and BChE inhibitory activities of crude methanolic extract (Nm.Cr), subsequent fractions; n-hexane (Nm.Hex), chloroform (Nm.Cf), ethyl acetate (Nm.EtAc), aqueous (Nm...
November 23, 2017: BMC Complementary and Alternative Medicine
Madeeha Subhan, Waleed Sadiq
Kartagener syndrome (KS) is a rare autosomal recessive genetic ciliary disorder characterized by situs inversus, chronic sinusitis, bronchiectasis, and infertility. KS is associated with ultrastructural anomalies of the cilia in epithelial cells covering the upper and lower respiratory tracts and spermatozoa flagella. This case describes a patient with KS with situs inversus and sudden onset bronchiectasis with a sharp decline in respiratory function presenting later in life but without sinusitis or infertility...
September 11, 2017: Curēus
Sadiq Naveed, Tooba Qadir, Tayyaba Afzaal, Ahmed Waqas
In recent decades, great strides have been made in understanding the science of suicide. Thus, it is imperative that Pakistani legal systems bridge the gap between Pakistani law and science. For instance, recent discoveries in public health, psychology, and neurobiology have shaped the etiological model of suicidal behavior and highlighted the high preponderance of certain psychiatric patients towards suicide. We present here a brief overview of psychiatric evidence implicated in suicides to better inform the Pakistani legal system of advances in the psychiatric literature...
September 8, 2017: Curēus
Nausheen Waheed Sadiq, Diane Beauchemin
A simple and fast method was developed for risk assessment of As, Cr and Se in food, which is demonstrated here using three cooked and uncooked rice samples (basmati as well as organic white and brown rice). The bio-accessible fraction was first determined through on-line leaching of rice mini-columns (maintained at 37 ºC) sequentially with artificial saliva, gastric juice and intestinal juice while continuously monitoring potentially toxic elements (As, Cr and Se) by inductively coupled plasma mass spectrometry (ICPMS)...
November 18, 2017: Analytical Chemistry
Guangji Hu, Tianyi Liu, James Hager, Kasun Hewage, Rehan Sadiq
The rapid expansion of unconventional natural gas production has triggered considerable public concerns, particularly regarding environmental and human health (EHH) risks posed by various chemical additives used in hydraulic fracturing (HF) operations. There is a need to assess the potential EHH hazards of additives used in real-world HF operations. In this study, HF additive and fracturing fluid data was acquired, and EHH hazards were assessed using an indexing approach. The indexing system analyzed chemical toxicological data of different ingredients contained within additives and produced an aggregated EHH safety index for each additive, along with an indicator describing the completeness of the chemical toxicological data...
November 14, 2017: Science of the Total Environment
Neil J Bruce, Gaurav K Ganotra, Daria B Kokh, S Kashif Sadiq, Rebecca C Wade
The recent and growing evidence that the efficacy of a drug can be correlated to target binding kinetics has seeded the development of a multitude of novel methods aimed at computing rate constants for receptor-ligand binding processes, as well as gaining an understanding of the binding and unbinding pathways and the determinants of structure-kinetic relationships. These new approaches include various types of enhanced sampling molecular dynamics simulations and the combination of energy-based models with chemometric analysis...
November 10, 2017: Current Opinion in Structural Biology
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