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https://www.readbyqxmd.com/read/27924252/how-to-conduct-a-systematic-review-a-narrative-literature-review
#1
REVIEW
Nusrat Jahan, Sadiq Naveed, Muhammad Zeshan, Muhammad A Tahir
Systematic reviews are ranked very high in research and are considered the most valid form of medical evidence. They provide a complete summary of the current literature relevant to a research question and can be of immense use to medical professionals. Our goal with this paper is to conduct a narrative review of the literature about systematic reviews and outline the essential elements of a systematic review along with the limitations of such a review.
November 4, 2016: Curēus
https://www.readbyqxmd.com/read/27923497/in-vivo-anti-inflammatory-activity-and-docking-study-of-newly-synthesized-benzimidazole-derivatives-bearing-oxadiazole-and-morpholine-rings
#2
Ankita Rathore, Raja Sudhakar, Mohamed Jawed Ahsan, Abuzer Ali, Naidu Subbarao, Surender Singh Jadav, Sadiq Umar, M Shahar Yar
In search of potential therapeutics for inflammatory disease, we report herein the synthesis, characterization and anti-inflammatory activities of a new series of 1-{(5-substituted-1,3,4-oxadiazol-2-yl)methyl}-2-(morpholinomethyl)-1H-benzimidazoles (5a-r). The anti-inflammatory activity of the compounds was evaluated using carrageenan induced rat paw edema test. Some compounds showed excellent anti-inflammatory activity in carrageenan induced rat paw edema test. 1-{(5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl)methyl}-2-(morpholinomethyl)-1H-benzimidazole (5g) showed maximum anti-inflammatory (74...
November 29, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27922990/robotically-assisted-thoracic-surgery-proposed-guidelines-for-privileging-and-credentialing
#3
Faiz Y Bhora, Adnan M Al-Ayoubi, Sadiq S Rehmani, Craig M Forleiter, Wissam N Raad, Scott G Belsley
OBJECTIVE: Increased use of robotically assisted thoracic surgery (RATS) necessitates effective credentialing guidelines to ensure safe outcomes. We provide a stepwise algorithm for granting privileges and credentials in RATS. This algorithm reflects graduated responsibility and complexity of the surgical procedures performed. Furthermore, it takes into account volume, outcomes, surgeon's competency, and appropriateness of robot usage. METHODS: We performed a literature review for available strategies to grant privileges and credentials for implementing robotic surgery...
December 5, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27919736/effect-of-morin-5-sulfonic-acid-sodium-salt-on-the-expression-of-apoptosis-related-proteins-caspase-3-bax-and-bcl-2-due-to-the-mercury-induced-oxidative-stress-in-albino-rats
#4
Rantham Subramaniam Venkatesan, Abdul Majeeth Mohamed Sadiq
Many environmental contaminants have been reported to disturb the pro-oxidant or antioxidant balance of the cells by inducing oxidative stress. Oxidative stress mediated by the HgCl2 induces DNA, protein and lipid oxidation resulted in necrosis or apoptosis, or both. Currently flavonoids are being emerging topic and reported to have antiviral, anti-inflammatory, anti- tumor and antioxidant activities. Morin is one of the flavonoid protects the cells from oxygen free radical damage and scavenges the free radicals and metals and also heals the injured cells commercially...
December 2, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27919287/chemical-profiling-antimicrobial-and-insecticidal-evaluations-of-polygonum-hydropiper-l
#5
Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Abdul Sadiq, Muhammad Ovais, Waqar Ahmad, Sajjad Ahmad, Anwar Zeb
BACKGROUND: The emergence of multidrug resistant (MDR) pathogens is of great concern to the global health community. Our ability to effectively treat diseases is based on the discovery of potent drugs for the treatment of these challenging diseases. Traditional medicines are one of the major sources for the discovery of safe, effective and economical drug candidates. In order to validate its antibacterial, antifungal and insecticidal potentials with respect to traditional uses, we have screened for the first time Polygonum hydropiper against pathogenic bacterial, fungal strains and a variety of insects...
December 5, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27913777/risk-factors-for-major-bleeding-in-the-seattle-ii-trial
#6
Immad Sadiq, Samuel Z Goldhaber, Ping-Yu Liu, Gregory Piazza
Ultrasound-facilitated, catheter-directed, low-dose fibrinolysis minimizes the risk of intracranial bleeding compared with systemic full-dose fibrinolytic therapy for pulmonary embolism (PE). However, major bleeding is nevertheless a potential complication. We analyzed the 150-patient SEATTLE II trial of submassive and massive PE patients to describe those who suffered major bleeding events following ultrasound-facilitated, catheter-directed, low-dose fibrinolysis and to identify risk factors for bleeding. Major bleeding was defined as GUSTO severe/life-threatening or moderate bleeds within 72 hours of initiation of the procedure...
December 1, 2016: Vascular Medicine
https://www.readbyqxmd.com/read/27913418/a-novel-rhamnose-rich-hetero-exopolysaccharide-isolated-from-lactobacillus-paracasei-dg-activates-thp-1-human-monocytic-cells
#7
Silvia Balzaretti, Valentina Taverniti, Simone Guglielmetti, Walter Fiore, Mario Minuzzo, Hansel N Ngo, Judith B Ngere, Sohaib Sadiq, Paul N Humphreys, Andrew P Laws
: Lactobacillus paracasei DG is a bacterial strain with recognized probiotic properties and is used in commercial probiotic products. However, the mechanisms underlying its probiotic properties are mainly unknown. In this study, we tested the hypothesis that the capability of strain DG to interact with the host is, at least partly, associated with its ability to synthesize a surface-associated exopolysaccharide (EPS). Comparative genomics revealed the presence of putative EPS gene clusters in DG genome; accordingly, EPS was isolated from the surface of the bacterium...
December 2, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27895364/a-10-year-review-of-indications-for-penetrating-keratoplasty-in-a-tertiary-care-setting-in-karachi-pakistan
#8
Tanveer Ajum Chaudhry, Salman Naveed Sadiq, Zubaida Sirang, Maheen Akhtar Syed, Mustafa Kamal, Khabir Ahmad
The retrospective study was conducted to determine the indications and outomes of penetrating keratoplasty(PKP) in a tertiary care setting in Pakistan. All eyes that had undergone PKP between January 2005 and December 2014 at the Aga Khan University Hospital, Karachi, were included.Data were collected on the indications of PKP, graft survival (graft clarity at final follow-up), andbest corrected visual acuity (BCVA).Kaplan-Meier\'s method was usedto analyse graft survival.Out of 437 eyes, 383(87%) were for visual purpose...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27886514/sugar-based-novel-niosomal-nanocarrier-system-for-enhanced-oral-bioavailability-of-levofloxacin
#9
Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdelbary M A Elhissi, Waqas Nawaz, Farid Ahmad, Abdul Sadiq, Imdad Ali
CONTEXT: Vesicular systems have attracted great attention in drug delivery because of their amphiphilicity, biodegradability, non-toxicity and potential for increasing drug bioavailability. OBJECTIVE: A novel sugar-based double-tailed surfactant containing renewable block was synthesized for preparing niosomal vesicles that could be exploited for Levofloxacin encapsulation, aiming to increase its oral bioavailability. MATERIALS AND METHODS: The surfactant was characterized by (1)H NMR, mass spectroscopy and Fourier transform infrared spectroscopy (FT-IR)...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27885553/biosimilars-for-the-treatment-of-chronic-inflammatory-diseases-a-systematic-review-of-published-evidence
#10
REVIEW
Ira Jacobs, Danielle Petersel, Leah Isakov, Sadiq Lula, K Lea Sewell
BACKGROUND: Clinicians are required to assimilate, critically evaluate, and extrapolate information to support appropriate use of biosimilars across indications. OBJECTIVES: The objective of this study was to systematically collate all published data in order to assess the weight (quantity and quality) of available evidence for each molecule and inform and support healthcare decision-making in chronic inflammatory diseases. METHODS: MEDLINE(®), EMBASE(®), and ISI Web of Science(®) were searched to September 2015...
December 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/27884965/-can-you-recommend-any-good-sti-apps-a-review-of-content-accuracy-and-comprehensiveness-of-current-mobile-medical-applications-for-stis-and-related-genital-infections
#11
Jo Gibbs, Voula Gkatzidou, Laura Tickle, Sarah R Manning, Tilna Tilakkumar, Kate Hone, Richard E Ashcroft, Pam Sonnenberg, S Tariq Sadiq, Claudia S Estcourt
OBJECTIVE: Seeking sexual health information online is common, and provision of mobile medical applications (apps) for STIs is increasing. Young people, inherently at higher risk of STIs, are avid users of technology, and apps could be appealing sources of information. We undertook a comprehensive review of content and accuracy of apps for people seeking information about STIs. METHODS: Search of Google Play and iTunes stores using general and specific search terms for apps regarding STIs and genital infections (except HIV), testing, diagnosis and management, 10 September 2014 to 16 September 2014...
November 24, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27881119/antibacterial-and-antifungal-potentials-of-the-solvents-extracts-from-eryngium-caeruleum-notholirion-thomsonianum-and-allium-consanguineum
#12
Abdul Sadiq, Sadiq Ahmad, Rahmat Ali, Fawad Ahmad, Sajjad Ahmad, Anwar Zeb, Muhammad Ayaz, Farhat Ullah, Abu Nasar Siddique
BACKGROUND: Herbal medicines have long been used for various ailments in various societies and natural bioactive compounds are gaining more and more importance due to various factors. In this context, three plant species i.e., Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum have been aimed for the scientific verification of their purported traditional uses against various infectious diseases. METHODS: In this study, three plants were assayed for antibacterial and antifungal potentials...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27843861/dual-bacillus-calmette-guerin-vaccination-along-the-border-communities-of-angola-and-namibia
#13
Abubakar Sadiq Umar, Lusamba Kabamba
Without a doubt, the synchronization of public health intervention on health issues along the international border will enhance the control of epidemic-prone disease and other health-related behavior. However, the lack of holistic planning and the involvement of the members of border communities could result in undesired health related events. This report advanced reasons that could have resulted in a child receiving two separate doses of Bacillus Calmette-Guerin vaccine within the first 4 days of life in two different health facilities...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27826064/retinopathy-of-prematurity-in-pakistan
#14
Mohammad Ali A Sadiq, Irfan Karamat, Asad Aslam Khan
Screening guidelines for retinopathy of prematurity recommended by the American Academy of Pediatrics and the American Association for Pediatric Ophthalmology and Strabismus suggest screening infants of birth weight of ≤1500 g and/or 32 weeks' gestational age or less. In developing and middle-income countries, ROP has been reported in older and/or heavier infants. We prospectively studied 172 infants of gestational age 36 weeks and younger and/or birth weight of ≤3000 g over a period of 16 months. ROP was identified in 4 infants >32 weeks of age, 1 infant having a birth weight of 2000 g...
December 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27822958/double-tailed-acyl-glycoside-niosomal-nanocarrier-for-enhanced-oral-bioavailability-of-cefixime
#15
Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdul Sadiq, Imdad Ali, Farid Ahmed, Waqas Nawaz
Novel, safe, efficient, and cost effective surfactants from renewable resources has attracted attention for enhancing solubility and bioavailability of hydrophobic dugs. We report the synthesis, characterization, and biocompatibility of a novel non-ionic acyl glycoside double-tailed surfactant for niosomal drug delivery system. Structure of the surfactant was confirmed by (1)H NMR and mass spectroscopy. Applications of surfactant in niosomal drug delivery were explored using Cefixime as model. The shape, size, and polydispersity index (PDI) of drug loaded vesicles were investigated with atomic force microscope (AFM) and dynamic light scattering (DLS)...
November 8, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27814643/cellular-efflux-transporters-and-the-potential-role-of-natural-products-in-combating-efflux-mediated-drug-resistance
#16
Muhammad Ayaz, Fazal Subhan, Abdul Sadiq, Farhat Ullah, Jawad Ahmed, Robert D E Sewell
Efflux mediated multidrug resistance (MDR) is a major problem in the treatment of bacterial, fungal and protozoal infections in addition to cancer chemotherapy. Among other well known mechanisms, efflux pumps are significant contributors to chemo-resistance. Efflux mediated resistance generally occurs through up-regulation of genes responsible for the expression of transporter proteins extruding drugs from the cell to create intracellular sub-therapeutic concentrations leading to resistance. The rapid expansion of MDR pathogens necessitates the discovery of resistance modifying drugs, which in combination with antimicrobial or chemotherapeutic agents would tend to reinstate the action of these drugs and avert the emergence of acquired resistance...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27810759/microbial-quality-of-reclaimed-water-for-urban-reuses-probabilistic-risk-based-investigation-and-recommendations
#17
Gyan Chhipi-Shrestha, Kasun Hewage, Rehan Sadiq
Although Canada has abundant freshwater resources, many cities still experience seasonal water shortage. Supply-side and demand-side management is a core strategy to address this water shortage. Under this strategy, reclaimed water, which the Canadian public is willing to use for non-potable purposes, is an option. However, no universal guidelines exist for reclaimed water use. Despite the federal government's long-term goal to develop guidelines for many water reuse applications, guidelines have only been prescribed for reclaimed water use in toilet and urinal flushing in Canada...
October 28, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27807766/monoclonal-antibody-and-fusion-protein-biosimilars-across-therapeutic-areas-a-systematic-review-of-published-evidence
#18
REVIEW
Ira Jacobs, Danielle Petersel, Lesley G Shane, Chee-Keng Ng, Carol Kirchhoff, Gregory Finch, Sadiq Lula
BACKGROUND: Despite regulatory efforts to formalize guidance policies on biosimilars, there remains a need to educate healthcare stakeholders on the acknowledged definition of biosimilarity and the data that underpin it. OBJECTIVES: The objectives of the study were to systematically collate published data for monoclonal antibodies and fusion protein biosimilars indicated for cancer, chronic inflammatory diseases, and other indications, and to explore differences in the type and weight (quantity and quality) of available evidence...
November 2, 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/27780618/synthesis-structure-activity-relationship-and-molecular-docking-of-3-oxoaurones-and-3-thioaurones-as-acetylcholinesterase-and-butyrylcholinesterase-inhibitors
#19
Ehsan Ullah Mughal, Amina Sadiq, Shahzad Murtaza, Hummera Rafique, Muhammad Naveed Zafar, Tauqeer Riaz, Bilal Ahmad Khan, Abdul Hameed, Khalid Mohammed Khan
The present study describes efficient and facile syntheses of varyingly substituted 3-thioaurones from the corresponding 3-oxoaurones using Lawesson's reagent and phosphorous pentasulfide. In comparison, the latter methodology was proved more convenient, giving higher yields and required short and simple methodology. The structures of synthetic compounds were unambiguously elucidated by IR, MS and NMR spectroscopy. All synthetic compounds were screened for their inhibitory potential against in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes...
October 14, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27763789/facebook-discussion-groups-provide-a-robust-worldwide-platform-for-free-pathology-education
#20
Raul S Gonzalez, Sadiq M Amer, Nejib Ben Yahia, Felipe D'Almeida Costa, Manu Noatay, Jian-Hua Qiao, Flavia G Rosado, Yale Rosen, Bruno Tavares Sedassari, Rhonda K Yantiss, Jerad M Gardner
CONTEXT: -Facebook (Menlo Park, California) is one of many online sites that provide potential educational tools for pathologists. We have each founded Facebook groups dedicated to anatomic pathology, in which members can share cases, ask questions, and contribute to discussions. OBJECTIVES: -To report our experiences in founding and maintaining these Facebook groups and to characterize the contributed content. DESIGN: -We circulated a survey among the group founders, then compiled and analyzed the responses...
October 20, 2016: Archives of Pathology & Laboratory Medicine
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