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https://www.readbyqxmd.com/read/29149752/hazard-assessment-of-hydraulic-fracturing-chemicals-using-an-indexing-method
#1
Guangji Hu, Tianyi Liu, James Hager, Kasun Hewage, Rehan Sadiq
The rapid expansion of unconventional natural gas production has triggered considerable public concerns, particularly regarding environmental and human health (EHH) risks posed by various chemical additives used in hydraulic fracturing (HF) operations. There is a need to assess the potential EHH hazards of additives used in real-world HF operations. In this study, HF additive and fracturing fluid data was acquired, and EHH hazards were assessed using an indexing approach. The indexing system analyzed chemical toxicological data of different ingredients contained within additives and produced an aggregated EHH safety index for each additive, along with an indicator describing the completeness of the chemical toxicological data...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29132080/new-approaches-for-computing-ligand-receptor-binding-kinetics
#2
REVIEW
Neil J Bruce, Gaurav K Ganotra, Daria B Kokh, S Kashif Sadiq, Rebecca C Wade
The recent and growing evidence that the efficacy of a drug can be correlated to target binding kinetics has seeded the development of a multitude of novel methods aimed at computing rate constants for receptor-ligand binding processes, as well as gaining an understanding of the binding and unbinding pathways and the determinants of structure-kinetic relationships. These new approaches include various types of enhanced sampling molecular dynamics simulations and the combination of energy-based models with chemometric analysis...
November 10, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29123571/case-on-caffeine-toxicity-and-learning-points
#3
Sadiq Gbadebo, Sarah Colpus, Daniel Felstead
No abstract text is available yet for this article.
November 2017: J Intensive Care Soc
https://www.readbyqxmd.com/read/29119068/ischemic-stroke-of-midbrain-and-cerebellum-involving-reticular-activating-system
#4
Waleed Sadiq, Madeeha Subhan
The reticular activating system is the part of the brain that maintains the sleep/wake cycle. Any damage to this region can cause hypersomnolence and drowsiness along with altered sensorium. This case presents a patient with cerebellar and midbrain stroke with infarct of the reticular activating system, leading to hypersomnolence, drowsiness, and altered sensorium.
September 1, 2017: Curēus
https://www.readbyqxmd.com/read/29116477/4egi-1-represses-cap-dependent-translation-and-regulates-genome-wide-translation-in-malignant-pleural-mesothelioma
#5
Arpita De, Blake A Jacobson, Mark S Peterson, Joe Jay-Dixon, Marian G Kratzke, Ahad A Sadiq, Manish R Patel, Robert A Kratzke
Deregulation of cap-dependent translation has been implicated in the malignant transformation of numerous human tissues. 4EGI-1, a novel small-molecule inhibitor of cap-dependent translation, disrupts formation of the eukaryotic initiation factor 4F (eIF4F) complex. The effects of 4EGI-1-mediated inhibition of translation initiation in malignant pleural mesothelioma (MPM) were examined. 4EGI-1 preferentially inhibited cell viability and induced apoptosis in MPM cells compared to normal mesothelial (LP9) cells...
November 8, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29113033/association-between-lameness-and-indicators-of-dairy-cow-welfare-based-on-locomotion-scoring-body-and-hock-condition-leg-hygiene-and-lying-behavior
#6
REVIEW
Mohammed B Sadiq, Siti Z Ramanoon, Wan Mastura Shaik Mossadeq, Rozaihan Mansor, Sharifah Salmah Syed-Hussain
Dairy cow welfare is an important consideration for optimal production in the dairy industry. Lameness affects the welfare of dairy herds by limiting productivity. Whilst the application of LS systems helps in identifying lame cows, the technique meets with certain constraints, ranging from the detection of mild gait changes to on-farm practical applications. Recent studies have shown that certain animal-based measures considered in welfare assessment, such as body condition, hock condition and leg hygiene, are associated with lameness in dairy cows...
November 5, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29111168/standardized-programming-to-reduce-the-burden-of-inappropriate-therapies-in-implantable-cardioverter-defibrillators-single-centre-follow-up-results
#7
U Boles, E Gul, L Fitzgerald, F Sadiq Ali, Christine Nolan, K Aldworth-Gaumond, D R Redfearn, A Baranchuk, B Glover, C Simpson, H Abdollah, K A Michael
BACKGROUND: Current algorithms and device morphology templates have been proposed in current Implantable Cardioverter-Defibrillators (ICDs) to minimize inappropriate therapies (ITS), but this has not been completely successful. AIM: Assess the impact of a deliberate strategy of using an atrial lead implant with standardized parameters; based on all current ICD discriminators and technologies, on the burden of ITS. METHOD: A retrospective single-centre analysis of 250 patients with either dual chamber (DR) ICDs or biventricular ICDs (CRTDs) over a (41...
October 27, 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29110230/colonic-adenocarcinoma-with-florid-vascular-proliferation-related-to-intussusception
#8
Pallavi Rao, Anisha Sawkar, Srikanth Narayanaswamy, Nandita Ghosal, Sadiq S Sikora
No abstract text is available yet for this article.
November 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29107886/determination-of-rare-earth-elements-concentration-at-different-depth-profile-of-precambrian-pegmatites-using-instrumental-neutron-activation-analysis
#9
Abubakar Sadiq Aliyu, Yahaya Musa, M S Liman, Habu T Abba, Mohammed S Chaanda, Nnamani C Ngene, N N Garba
The Keffi area hosts abundant pegmatite bodies as a result of the surrounding granitic intrusions. Keffi is part of areas that are geologically classified as North Central Basement Complex. Data on the mineralogy and mineralogical zonation of the Keffi pegmatite are scanty. Hence the need to understand the geology and mineralogical zonation of Keffi pegmatites especially at different depth profiles is relevant as a study of the elemental composition of the pegmatite is essential for the estimation of its economic viability...
November 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29091754/a-targetable-egfr-dependent-tumor-initiating-program-in-breast-cancer
#10
Paul Savage, Alexis Blanchet-Cohen, Timothée Revil, Dunarel Badescu, Sadiq M I Saleh, Yu-Chang Wang, Dongmei Zuo, Leah Liu, Nicholas R Bertos, Valentina Munoz-Ramos, Mark Basik, Kevin Petrecca, Jamil Asselah, Sarkis Meterissian, Marie-Christine Guiot, Atilla Omeroglu, Claudia L Kleinman, Morag Park, Jiannis Ragoussis
Therapies targeting epidermal growth factor receptor (EGFR) have variable and unpredictable responses in breast cancer. Screening triple-negative breast cancer (TNBC) patient-derived xenografts (PDXs), we identify a subset responsive to EGFR inhibition by gefitinib, which displays heterogeneous expression of wild-type EGFR. Deep single-cell RNA sequencing of 3,500 cells from an exceptional responder identified subpopulations displaying distinct biological features, where elevated EGFR expression was significantly enriched in a mesenchymal/stem-like cellular cluster...
October 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/29091446/insight-into-flufenamic-acid-cocrystal-dissolution-in-the-presence-of-a-polymer-in-solution-from-single-crystal-to-powder-dissolution
#11
Minshan Guo, Ke Wang, Ning Qiao, László Fábián, Ghazala Sadiq, Mingzhong Li
Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior of the cocrystals of flufenamic acid with theophylline (FFA-TP CO) and nicotinamide (FFA-NIC CO) were investigated at multiple length scales. At the molecular level, the interactions of crystal surfaces with a polymer were analyzed by observing etching pattern changes using atomic force microscopy. At the macroscopic scale, dissolution rates of particular faces of a single crystal were determined by measurement of the physical retreat velocities of the faces using optical light microscopy...
November 10, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29083954/screening-of-antibiotic-residues-in-fresh-milk-of-kathmandu-valley-nepal
#12
Bal Kumari Sharma Khanal, Muhammad Bilal Sadiq, Manisha Singh, Anil Kumar Anal
The prevalence of two groups of antibiotics; namely penicillin and sulfonamides was studied in fresh milk available in Kathmandu Valley of Nepal. The milk samples (n = 140) were collected from three different sources; individual farmers, cottage dairies and organized dairies of Kathmandu valley. Qualitative and semi-quantitative analysis with rapid screening kits revealed that 23% samples were positive for antibiotic residues in the fresh milk for penicillin and sulfonamide groups (1-256 µg/kg). High performance liquid chromatography (HPLC) analyses detected 81% samples positive for amoxicillin (68-802 µg/kg), 41% for sulfadimethoxine (31-69 µg/kg), 27% for penicillin G (13-353 µg/kg), and 12% for ampicillin (0...
October 30, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29067041/paediatric-inflammatory-bowel-disease-clinical-presentation-and-disease-location
#13
Danish Abdul Aziz, Maryum Moin, Atif Majeed, Kamran Sadiq, Abdul Gaffar Biloo
OBJECTIVE: To determine different clinical presentationsand disease location demarcatedby upper and lower gastrointestinal endoscopyand relevant histopathologyin children diagnosed with inflammatory bowel disease (IBD). METHODS: This is 5 years (2010 to 2015) retrospective studyconducted at the Aga Khan University Hospitalenrolling65admitted children between 6 months to 15years from either gender, diagnosed with IBD on clinical presentation, endoscopy and biopsy...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29063898/pattern-of-presentation-of-gastroesophageal-reflux-disease-among-patients-with-dyspepsia-in-kano-nigeria
#14
Abubakar Sadiq Maiyaki, Musa Muhammed Borodo, Adamu Alhaji Samaila, Abdulmumini Yakubu
BACKGROUND: Dyspepsia is a symptom complex rather than a specific disease entity. It can be caused by both organic and functional gastrointestinal (GI) disorders. Gastroesophageal reflux disease (GORD) though a common digestive disorder worldwide is scarcely reported in Nigeria. The aim of this study is to determine the pattern of presentation of GORD among patients with dyspepsia. METHODS: One hundred and seventy dyspeptic patients were recruited consecutively as they were referred to the Gastroenterology Unit of Aminu Kano Teaching Hospital for upper GI endoscopy...
October 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/29062334/does-female-education-explain-the-disparity-in-the-use-of-antenatal-and-natal-services-in-nigeria-evidence-from-demographic-and-health-survey-data
#15
Abubakar Sadiq Umar
BACKGROUND: Nigeria is among the countries with a high number of annual maternal deaths partly due to low utilization of maternal health services (MHS). OBJECTIVE: This study aimed to explore whether there is an association between women's level of education and the appropriate use of antenatal and delivery services. METHOD: A quantitative cross-sectional study was used to analyze the Nigerian Demographic and Health Survey (NDHS) data. Information from 33,385 women aged 15 - 49 years was analyzed using Bivariate Pearson Chi square test and multiple logistic regressions...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29056913/anti-alzheimer-s-studies-on-%C3%AE-sitosterol-isolated-from-polygonum-hydropiper-l
#16
Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Abdul Sadiq, Gowhar Ali, Muhammad Ovais, Muhammad Shahid, Ashfaq Ahmad, Abdul Wadood, Mohamed El-Shazly, Nisar Ahmad, Sajjad Ahmad
The family Polygonaceae is known for its traditional use in the management of various neurological disorders including Alzheimer's disease (AD). In search of new anti-AD drugs, β-sitosterol isolated from Polygonum hydropiper was subjected to in vitro, in vivo, behavioral and molecular docking studies to confirm its possibility as a potential anti-Alzheimer's agent. The in vitro AChE, BChE inhibitory potentials of β-sitosterol were investigated following Ellman's assay. The antioxidant activity was tested using DPPH, ABTS and H2O2 assays...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29039321/assessment-of-thyroid-hormone-levels-and-thyroid-disorders-a-case-study-from-gujranwala-pakistan
#17
Narjis Naz, Shakera Khatoon Rizvi, Zubi Sadiq
This case study is conducted to investigate the thyroid hormone levels and relevant disorders including evaluation of dietary conditions in the rural area of Gujranwala and its surrounding districts. Thyroid disorders are clinically prevalent and their manifestation differs considerably with geographical variations. A randomized study of 177 subjects was carried out, with a questionnaire about their dietary habits/life style and acquisition of blood samples for thyroid hormone level assessment using radioimmunoassay technique...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29037707/predominant-yeasts-in-chinese-traditional-sourdough-and-their-influence-on-aroma-formation-in-chinese-steamed-bread
#18
Tongjie Liu, Yang Li, Faizan A Sadiq, Huanyi Yang, Jingsi Gu, Lei Yuan, Yuan Kun Lee, Guoqing He
A total of 105 yeast isolates was obtained from 15 sourdough samples collected from different regions in China and subjected to random amplified polymorphic DNA (RAPD) analysis. Six species were identified including Pichia membranifaciens, which has not previously been reported in Chinese sourdoughs. Different species of yeast were used in single-culture fermentation to make Chinese steamed bread (CSB). The volatiles of the CSB were captured by solid-phase microextraction method, separated and identified by gas chromatography-mass spectrometry...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29027376/adenosine-a2a-receptor-agonist-ameliorates-eae-and-correlates-with-th1-cytokine-induced-blood-brain-barrier-dysfunction-via-suppression-of-mlck-signaling-pathway
#19
Ying Liu, Marwan Alahiri, Bianca Ulloa, Boxun Xie, Saud A Sadiq
INTRODUCTION: Multiple sclerosis (MS) disease activity is associated with blood-brain barrier (BBB) disruption, which is mediated by inflammatory cytokines released by CD4+ lymphocytes. To assess the effects of adenosine A2A receptors on BBB permeability in vitro and in vivo. METHODS: A2A receptor expression was detected by immunostaining in experimental autoimmune encephalomyelitis (EAE) C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG)35-55 , and human MS brain...
October 12, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29021906/a-pilot-biomechanical-assessment-of-curling-deliveries-is-toe-sliding-more-likely-to-cause-knee-injury-than-flatfoot-sliding
#20
Iona Robertson, Graham P Arnold, Weijie Wang, Tim S Drew, Sadiq Nasir, Calum MacDonald, Rami J Abboud
BACKGROUND: The aim of this study was to determine whether toe sliding is more likely to cause knee injuries than flatfoot sliding in curling. METHODS: Twelve curlers participated in the study, each delivering 12 stones. Six stones per volunteer were delivered using a flatfoot slide and six were delivered using a toe slide. The Pedar-X in-shoe pressure system recorded the plantar pressure during each of the slides, while a sagittal plane digital video recorded the body position of the curler...
2017: BMJ Open Sport & Exercise Medicine
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