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https://www.readbyqxmd.com/read/28818458/colonic-delivery-of-indometacin-loaded-pga-co-pdl-microparticles-coated-with-eudragit-l100-55-from-fast-disintegrating-tablets
#1
Hesham M Tawfeek, Ahmed A H Abdellatif, Thomas J Dennison, Afzal R Mohmmed, Younis Sadiq, Imran Y Saleem
The aim of this work was to investigate the efficient targeting and delivery of indometacin (IND), as a model anti-inflammatory drug to the colon for treatment of inflammatory bowel disease. We prepared fast disintegrating tablets (FDT) containing IND encapsulated within poly(glycerol-adipate-co-ɷ-pentadecalactone), PGA-co-PDL, microparticles and coated with Eudragit L100-55 at different ratios (1:1.5, 1:1, 1:0.5). Microparticles encapsulated with IND were prepared using an o/w single emulsion solvent evaporation technique and coated with Eudragit L-100-55 via spray drying...
August 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28815479/validation-of-the-internet-addiction-test-in-students-at-a-pakistani-medical-and-dental-school
#2
Ahmed Waqas, Faisal Farooq, Mohsin Raza, Saamia Tahir Javed, Spogmai Khan, Mahrukh Elahi Ghumman, Sadiq Naveed, Mark Haddad
Despite growing concerns over pathological internet usage, studies based on validated psychometric instruments are still lacking in Pakistan. This study aimed to examine the psychometric properties of the Internet Addiction Test (IAT) in a sample of Pakistani students. A total of 522 students of medicine and dentistry completed the questionnaire, which consisted of four sections: (a) demographics, (b) number of hours spent on the Internet per day, (c) English version of the IAT, and (d) the Defense Style Questionnaire-40...
August 17, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28810937/tweets-gangs-and-guns-a-snapshot-of-gang-communications-in-detroit
#3
Desmond Patton, Sadiq Patel, Jun Sung Hong, Megan Ranney, Marie Crandall, Lyle Dungy
The aim of this study is to determine the frequency of violent and criminal Twitter communications among gang-affiliated individuals in Detroit, Michigan. We analyzed 8.5 million Detroit gang members' tweets from January 2013 to March 2014 to assess whether they contained Internet banging-related keywords. We found that 4.7% of gangaffiliated user tweets consisted of terms related to violence and crime. Violence and crime-related communications fell into 4 main categories: (a) beefing (267,221 tweets), (b) grief (79,971 tweets), (c) guns (3,551 tweets), and (d) substance use and distribution (47,638 tweets)...
August 15, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28803723/perceived-social-support-among-patients-with-burn-injuries-a-perspective-from-the-developing-world
#4
Ahmed Waqas, Marvee Turk, Sadiq Naveed, Atif Amin, Harriet Kiwanuka, Neha Shafique, Muhammad Ashraf Chaudhry
BACKGROUND: Social support is among the most well-established predictors of post-burn psychopathology after burn. Despite a disproportionately large burden of burns in the developing world, the nature of social support among burn patients in this context remains elusive. We, therefore, seek to investigate social support and its biopsychosocial determinants among patients with burn injuries in Pakistan. METHODS: A cross-sectional study of 343 patients presenting with burn injuries at four teaching hospitals in the Punjab province of Pakistan was conducted...
August 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28783379/phenotypic-and-genetic-heterogeneity-within-biofilms-with-particular-emphasis-on-persistence-and-antimicrobial-tolerance
#5
Faizan A Sadiq, Steve Flint, YanJun Li, Kai Ou, Lei Yuan, Guo Qing He
Phenotypic changes or phase variation within biofilms is an important feature of bacterial dormant life. Enhanced resistance to antimicrobials is one of the distinct features displayed by a fraction of cells within biofilms. It is believed that persisters are mainly responsible for this phenotypic heterogeneity. However, there is still an unresolved debate on the formation of persisters. In this short review, we highlight all known genomic and proteomic changes encountered by bacterial cells within biofilms...
August 7, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28781889/evaluation-of-macular-and-peripapillary-vessel-flow-density-in-eyes-with-no-known-pathology-using-optical-coherence-tomography-angiography
#6
Muhammad Hassan, Mohammad Ali Sadiq, Muhammad Sohail Halim, Rubbia Afridi, Mohamed K Soliman, Salman Sarwar, Aniruddha Agarwal, Diana V Do, Quan Dong Nguyen, Yasir Jamal Sepah
PURPOSE: To assess normal vessel flow density (VFD) in macular and peripapillary regions of eyes with no known ocular pathology using optical coherence tomography angiography (OCTA). METHODS: AngioVue (Optovue, Fremont, CA, USA) was used to capture OCTA images. A 3 × 3 mm grid and a 4.5 × 4.5 mm grid was used to scan parafoveal and peripapillary regions, respectively. ReVue software was utilized to measure VFD in five sectors within the inner two circles of ETDRS grid in macular region and correlated to retinal thickness of same sectors...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28770871/yield-of-48-hour-holter-monitoring-in-children-with-unexplained-palpitations-and-significance-of-associated-symptoms
#7
Rabbia Aman, Ahmad Usaid Qureshi, Masood Sadiq
OBJECTIVE: To determine the yield of 48-hour Holter monitoring in children with unexplained palpitations and the significance of associated symptoms. METHODS: This descriptive study was conducted at the Children's Hospital and Institute of Child Health, Lahore, Pakistan, from January 1 to December 31, 2015. All children above 5 years of age with history of intermittent palpitations and normal basic cardiovascular workup were enrolled. A 48-hour Holter study was performed using Motara Holter Monitoring System...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28763942/solid-sampling-etv-icpoes-coupled-to-a-nebulization-pre-evaporation-system-for-direct-elemental-analysis-of-glutinous-rice-by-external-calibration-with-standard-solutions
#8
Nausheen Sadiq, Lily Huang, Farhad Kaveh, Diane Beauchemin
Because glutinous rice flour is consumed by millions of individuals around the world, its analysis is essential to ensure its safety. Solid sampling electrothermal vaporization (ETV) coupled to inductively coupled plasma optical emission spectrometry (ICPOES) allows for a quick analysis, precluding the need for time-consuming acid digestion that may also lead to analyte loss or contamination. However, the amount of sample that can be introduced without extinguishing the plasma is limited to about 4mg. The increase in plasma robustness resulting from the concurrent introduction of pre-evaporated water aerosol allows the introduction of 8mg of solid sample without extinguishing the plasma...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28762369/variable-presentation-of-retrocaval-ureter-report-of-four-cases-and-review-of-literature
#9
Muhammed Ahmed, Abdullahi Alhassan, Muhammad Abubakar Sadiq, Ahmad Tijjani Lawal, Ahmad Bello, Hussaini Yusuf Maitama
Retrocaval ureter is a rare anomaly in which the ureter passes behind the inferior vena cava due to abnormal embryogenesis. Very few cases have been reported from Africa. Although the anomaly is congenital, patients become symptomatic in the third or fourth decade of life. We reviewed the records of four patients with the diagnosis of retrocaval ureter and managed in our centre between January 2010 and December 2016. Three patients presented with recurrent colicky right flank pain while one was asymptomatic...
April 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28756277/new-carbazole-linked-1-2-3-triazoles-as-highly-potent-non-sugar-%C3%AE-glucosidase-inhibitors
#10
Shazia Iqbal, Maria Aqeel Khan, Kulsoom Javaid, Rabia Sadiq, Saba Fazal-Ur-Rehman, M Iqbal Choudhary, Fatima Z Basha
In the present study, a series of new carbazole linked 1H-1,2,3-triazoles (2-27) were synthesized via click reaction of N-propargyl-9H-carbazole (1) and azides of appropriate acetophenones and heterocycles. Synthesized carbazole triazoles including 7, 9, 10, 19, 20, and 23-26 (IC50=0.8±0.01-100.8±3.6μM), exhibited several folds more potent α-glucosidase inhibitory in vitro activity as compared to standard drug, acarbose. Compounds 2-5, 7-13, and 17-27 did not show any cytotoxicity against 3T3 cell lines, except triazoles 6, and 14-16...
July 16, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28754623/structural-re-arrangement-of-depolymerized-sodium-alginate-enriches-peltate-glandular-trichomes-and-essential-oil-production-of-spearmint
#11
Yawar Sadiq, M Masroor A Khan, Asfia Shabbir, Bilal Ahmad, Hassan Jaleel, Moin Uddin, Lalit Varshney
Over the past decade, radiation-degraded polysaccharides have been used as regulators of growth and development of plants in several crop plants. In quest of the possible reasons of previously established growth-promotion activity of irradiated sodium alginate (ISA), structural parameters of irradiated and un-irradiated sodium alginate were analysed using Ultraviolet-visible spectroscopy (UV-vis) and Fourier Transform Infrared spectroscopic (FT-IR) studies to develop an understanding of structure-property relationship...
July 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28748882/superiority-of-peginterferon-%C3%AE-2a-and-ribavirin-combination-over-peginterferon-%C3%AE-2a-monotherapy-in-the-management-of-hemodialysis-patients-with-chronic-hepatitis-c-virus-infection
#12
Saeed M G Al-Ghamdi, Nasser Alaulaqi, Abdullah A Al-Amoudi, Amenah Alghamdi, Abbas Zagnoon, Bakr Ben Sadiq
Hepatitis C virus (HCV) is a common infection affecting 15% of hemodialysis population in Saudi Arabia resulting in delay in transplantation and long-term complications. The use of peginterferon resulted in sustained virologic response (SVR) in 40%-85% of patients, especially if combined with ribavirin. The treatment is hampered by the high dropout due to anemia and requirement of blood transfusion resulting from this therapy. Some studies have shown that the addition of increasing dose of erythropoiesis-stimulating agents (ESA) and reduced dose of ribavirin results in reduced dropout rate with high SVR...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28740287/evaluating-the-antimicrobial-potential-of-green-cardamom-essential-oil-focusing-on-quorum-sensing-inhibition-of-chromobacterium-violaceum
#13
Abdullah, Ali Asghar, Masood Sadiq Butt, Muhammad Shahid, Qingrong Huang
Spices are well known for their taste and flavor imparting properties. Green cardamom (Elletaria cardamomum), a herb spice belongs to family Zingiberaceae. In current study, GC-MS analysis of green cardamom essential oil (CEO) resulted in identification of twenty-six compounds with α-terpinyl acetate (38.4%), 1,8-cineole (28.71%), linalool acetate (8.42%), sabinene (5.21%), and linalool (3.97%) as major bioactive components. Present study also described the antimicrobial properties like zone of inhibition, minimum inhibitory concentration against microbial strains with special emphasis on quorum sensing inhibition...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28734889/subaortic-membrane-and-hypertrophic%C3%A2-obstructive-cardiomyopathy-in-the-cardiac-catheterization-lab
#14
Musa A Sharkawi, Talhat Azemi, Brett Duncan, Immad Sadiq
No abstract text is available yet for this article.
July 19, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28720134/in-vitro-antioxidant-and-antimalarial-activities-of-leaves-pods-and-bark-extracts-of-acacia-nilotica-l-del
#15
Muhammad Bilal Sadiq, Pattamon Tharaphan, Kesinee Chotivanich, Joel Tarning, Anil Kumar Anal
BACKGROUND: The emergence of drug resistant malaria is threatening our ability to treat and control malaria in the Southeast Asian region. There is an urgent need to develop novel and chemically diverse antimalarial drugs. This study aimed at evaluating the antimalarial and antioxidant potentials of Acacia nilotica plant extracts. METHODS: The antioxidant activities of leaves, pods and bark extracts were determined by standard antioxidant assays; reducing power capacity, % lipid peroxidation inhibition and ferric reducing antioxidant power assay...
July 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28709663/pulmonary-resection-for-second-lung-cancer-after-pneumonectomy-a-population-based-study
#16
Adil Ayub, Sadiq S Rehmani, Adnan M Al-Ayoubi, Wissam Raad, Raja M Flores, Faiz Y Bhora
BACKGROUND: Pulmonary resection for a second lung cancer after pneumonectomy is generally considered to be at prohibitive risk. Using a population-based database, we examined treatment patterns and survival in patients who underwent pulmonary resection after pneumonectomy for lung cancer. METHODS: We queried the Surveillance, Epidemiology, and End Results (SEER) database (1988-2012) to identify patients who underwent pneumonectomy and subsequently experienced contralateral non-small cell lung cancer (NSCLC)...
July 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28709094/fit-for-purpose-wastewater-treatment-conceptualization-to-development-of-decision-support-tool-i
#17
Gyan Chhipi-Shrestha, Kasun Hewage, Rehan Sadiq
This article is the first in a series of two papers. Paper I focuses on model conceptualization and development, and Paper II in the series focuses on model validation and implementation. The amount of water reuse has been increasing across the globe. Wastewater can be treated based on the intended end use of reclaimed water. Fit-for-purpose wastewater treatment (WWT) simultaneously considers intended end use, economic viability, and environmental sustainability. WWT technologies differ mainly in terms of treatment efficiency, cost, energy use, and associated carbon emissions...
July 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28706763/comparison-of-knowledge-attitudes-and-practices-of-educated-and-uneducated-adults-regarding-human-immunodeficiency-virus-in-karachi-pakistan
#18
Zainab Ahmad, Sara Sadiq, Mariam Asghar, Alizay Rashid Khan, Omer Arif, Syed Hamza Shah, Shahrukh Nadeem, Yamna Waseem, Rafi Aibani, Ammar Salman Syed, Rabia M Mustafa, Zainab Abdulrahman, Kaneez Fatima
BACKGROUND: Despite the high prevalence of human immunodeficiency virus (HIV) in Pakistan, no prior work has been done to specifically highlight the importance of education as a social vaccine against HIV. Therefore, our study focuses on differences in knowledge and practices regarding HIV and acquired immunodeficiency syndrome (AIDS) among educated and uneducated adults. METHODOLOGY: A cross-sectional study was carried out in which data was collected from all over Karachi...
June 12, 2017: Curēus
https://www.readbyqxmd.com/read/28702910/a-novel-biocoagulant-agent-from-mushroom-chitosan-as-water-and-wastewater-therapy
#19
Oday Adnan, Zurina Z Abidin, Azni Idris, Suryani Kamarudin, Mothanna Sadiq Al-Qubaisi
A new commercial cationic polyelectrolyte chitosan (CM), obtained from the waste of mushroom production, was examined using models of water and wastewater namely kaolin and palm oil mill effluent (pome). As it is biocompatible, widely available, and economically feasible, chitosan mushroom has high potential to be a suitable replacement for alum. Also, it can be a promising alternative to chitosan obtained traditionally from Crustaceans due to its higher zeta potential and homogeneity based on the raw material required for its production...
July 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28700973/fit-for-purpose-wastewater-treatment-testing-to-implementation-of-decision-support-tool-ii
#20
Gyan Chhipi-Shrestha, Kasun Hewage, Rehan Sadiq
This paper is the second in a series of two papers. In Paper I, a decision support tool (DST), FitWater, was developed for evaluating the potential of wastewater treatment (WWT) trains for various water reuse applications. In the present paper, the proposed DST has been tested and implemented. FitWater has been tested with several existing WWT plants in Canada and the USA, demonstrating FitWater's effectiveness in estimating life cycle cost (LCC), health risk, and energy use. FitWater has also been implemented in a newly planned neighbourhood in the Okanagan Valley (BC, Canada) by developing 12 alternative WWT trains for water reuse in lawn and public parks irrigation...
July 9, 2017: Science of the Total Environment
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