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Muafia Jabeen, Muhammad Iqbal Choudhry, Ghulam Abbas Miana, Khondaker Miraz Rahman, Umer Rashid, Hidayat-Ullah Khan, Arshia, Abdul Sadiq
Steroidal hormones progesterone and testosterone play a vital role in breast and prostate cancers. In this research, we have synthesized and characterized a total of thirty-one (31) new nitrogenous derivatives of progesterone and testosterone. The synthesized derivatives (1-31) were screened for their anti-cancer potential against MCF-7 and PC-3 cell lines of breast using MTT assay. The compounds 1-31exhibited significant inhibitory potentials against MCF-7 and PC-3 cell lines. In MCF-7 assay, compound 17 displayed IC50 value of 04 ±0...
May 14, 2018: Steroids
Ameet Dhar, Fouzia Sadiq, Quentin M Anstee, Adam P Levene, Robert D Goldin, Mark R Thursz
BACKGROUND: Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent model of hepatic fibrosis. METHODS: HSC-LX2 cells were incubated with FXa and/or thrombin in cell culture, stained for αSMA and relative gene expression and gel contraction calculated...
May 8, 2018: BMC Gastroenterology
Hina Sadiq, Nazia Jamil
Bacterial strains, Bacillus cereus Lb (KF011486), Brevundimonas sp. A2 (JX996070), Bacillus cereus AZS and Bacillus sp. 11A, isolated from soil sample, were checked for their antimicrobial property against Bacillus as test organism. The bactericidal effect of the antagonistic strains against test organism was found to be at 1280, 1280, 40 and 160 arbitrary units (AU/ml), respectively. The Crude Antimicrobial Compound (CAC) had a bactericidal effect on target cell by degeneration of its cell wall. The chemical analysis of TLC purified extract of intracellular and extracellular antimicrobial compound produced by Bacillus cereus Lb by GC-MS analysis revealed the presence of organic compounds such as acetic acid and certain volatile organic substances such as, toluene, 2-butanone, etc...
May 2018: Pakistan Journal of Pharmaceutical Sciences
B Hygriv Rao, Mohammed Sadiq Azam, Geetesh Manik
OBJECTIVE: This is a case series of consecutive patients with past myocardial infarction presenting with Electrical Storm (ES) of unstable ventricular tachycardia (VT) treated by a protocol directed algorithm. METHODS: Management protocol involved treatment of reversible causes, ventilatory & hemodynamic support, administration of antiarrhythmic drugs (AAD) & maximally tolerated doses of beta-blockers, stellate ganglionectomy and Radiofrequency ablation (RFA) guided by Electro Anatomic Mapping (EAM)...
March 2018: Indian Heart Journal
Tricia Felin, Sadiq Naveed, Amna M Chaudhary
Aripiprazole is a third-generation atypical antipsychotic medication, which is widely used for various psychiatric disorders across the lifespan. Aripiprazole can cause side effects including headache, insomnia, agitation, nervousness, lightheadedness, dizziness, somnolence, akathisia, and weight gain. Neutropenia is a less frequent side effect of aripiprazole. The current article reviews a case of a 10-year-old African American boy who developed neutropenia with aripiprazole. It is important for clinicians to be aware of this rare side effect...
May 1, 2018: Journal of Psychosocial Nursing and Mental Health Services
Saqib A Gowani, Brett Hiendlmayr, Amged Abdelaziz, Robert Gallagher, Immad Sadiq, Jeffrey Hirst
A 60-year-old male presented 12 months after CABG surgery with a large pulsatile sternal mass. CT scan of the chest demonstrated a pseudoaneurysm originating from the mid saphenous vein graft to the PDA measuring 7.7 x 7.2 x 6.0 cm. After a multidisciplinary consultation, a decision was made to place a Jostent GraftMaster to completely seal the communication of the extravasation.
May 2018: Journal of Invasive Cardiology
Min Lu, Saad Sadiq, Daniel J Feaster, Hemant Ishwaran
Estimation of individual treatment effect in observational data is complicated due to the challenges of confounding and selection bias. A useful inferential framework to address this is the counterfactual (potential outcomes) model, which takes the hypothetical stance of asking what if an individual had received both treatments. Making use of random forests (RF) within the counterfactual framework we estimate individual treatment effects by directly modeling the response. We find that accurate estimation of individual treatment effects is possible even in complex heterogenous settings but that the type of RF approach plays an important role in accuracy...
2018: Journal of Computational and Graphical Statistics
Bipul Kumer De Sarker, Sadiq M Abdullahi, Zafrul Hassan, Jahangir Kabir, Sarat Badmus, Sarwar Alam, Mostafizur Rahman, Mohammad I Malek, Mallika Mahatma
AIMS: To compare the efficacy and safety of trabeculectomy with Ologen versus Mitomycin C in primary glaucoma Materials and methods: This is a prospective study of patients aged 18 years and above, diagnosed with primary glaucoma randomised to having trabeculectomy with Ologen or Mitomycin C. The primary outcome measure was success of trabeculectomy defined as intraocular pressure >5 mmHg but ≤21 mmHg. Complete success was defined as intraocular pressure achieved without anti-glaucoma medication and qualified success was defined as intraocular pressure achieved with additional anti-glaucoma medication...
April 1, 2018: European Journal of Ophthalmology
M Alhudhud, S Sadiq, H N Ngo, C Hidalgo-Cantabrana, P Ruas-Madiedo, D van Sinderen, P N Humphreys, A P Laws
Three strains of Bifidobacterium breve (JCM 7017, JCM 7019 and JCM 2258) and two strains of Bifidobacterium animalis subsp. lactis (AD011 and A1dOxR) were grown in broth cultures or on plates, and a standard exopolysaccharide extraction method was used in an attempt to recover exocellular polysaccharides. When the extracted materials were analysed by NMR it was clear that mixtures of polysaccharides were being isolated including exopolysaccharides (EPS) cell wall polysaccharides and intracellular polysaccharides...
April 26, 2018: Beneficial Microbes
Sadiq S Rehmani, Bian Liu, Adnan Al-Ayoubi, Wissam Raad, Raja M Flores, Faiz Bhora, Emanuela Taioli
BACKGROUND: Utilization of high-volume hospitals (HVH) for esophagectomy has been associated with improved perioperative outcomes and reduced mortality. We aimed to test the hypothesis that black-white racial disparities exist in HVH utilization, and to identify predictors of in-hospital surgical outcomes of esophageal cancer while adjusting for HVH utilization patterns. METHODS: We queried the New York Statewide Planning and Research Cooperative System (SPARCS) database (1995-2012) for esophageal cancer patients who underwent surgical resection exclusively...
April 20, 2018: Annals of Thoracic Surgery
Shah Hussain, Habib Ahmad, Sadiq Ullah, Najam-Ul-Sehar Afshan, Donald H Pfister, Hassan Sher, Haidar Ali, Abdul N Khalid
Parasola is a genus of small, veil-less coprinoid mushrooms in the family Psathyrellaceae (Agaricales). The genus is not well documented in Asia, specifically in Pakistan. In this study we describe two new species Parasola glabra and P. pseudolactea from Pakistan, based on morphological and molecular data. Phylogeny based on three DNA regions: nuc rDNA region encompassing the internal transcribed spacers 1 and 2 along with the 5.8S rDNA (ITS), nuc 28S rDNA D1-D2 domains (28S) and translation elongation factor 1 α gene ( TEF1α ) show that the new taxa are clustered in a clade formed by the members of section Parasola of genus Parasola ...
2018: MycoKeys
Butsadee Iamareerat, Manisha Singh, Muhammad Bilal Sadiq, Anil Kumar Anal
Biodegradable packaging in food materials is a green technology based novel approach to replace the synthetic and conventional packaging systems. This study is aimed to formulate the biodegradable cassava starch based films incorporated with cinnamon essential oil and sodium bentonite clay nanoparticles. The films were characterized for their application as a packaging material for meatballs. The cassava starch films incorporated with sodium bentonite and cinnamon oil showed significant antibacterial potential against all test bacteria; Escherichia coli , Salmonella typhimurium and Staphylococcus aureus...
May 2018: Journal of Food Science and Technology
Muhammad Zeshan, Ahmed Waqas, Sadiq Naveed, Hamzah Ghulam, Pankaj Manocha
Objective: Mental health disorders account for around 1.8 million inpatient community hospital stays in the U.S.A. Our study aims to highlight the factors impacting the length of stay at a community hospital in the U.S.A. Methods: We reviewed 300 randomly selected charts to examine the factors impacting the length of stay in an adolescent inpatient psychiatric unit in 2011 and 2015. All data were analyzed in SPSS v. 20 with multiple regression analysis. Results: Longer length of stay among adolescents was associated with multiple psychiatric diagnoses, co-occurring medical comorbidities, not living with biological parents, history of mental illness, legal problems, substance use in the family, seclusion, restraints during current admission, and schizophrenia...
April 2018: Journal of the Canadian Academy of Child and Adolescent Psychiatry
Shaukat Ali, Rubina, Sadiq Hussain
Objective: To assess the quality of freshwater aquifers (springs) associated diseases, and indigenous perception in Ghizer, Gilgit-Baltistan. Methods: This was a cross-sectional study conducted at the department of environmental science, Karakoram International University Gilgit after approval from departmental research committee. In order to get the most accurate results, 18 water samples in triplicates were collected according to our lab own set of sampling standard operating procedures (SOPs) using pre-sterilized bottles of 100 ml from June 2016 to August 2016 along with associated diseases record and structured interviews from indigenous population...
January 2018: Pakistan Journal of Medical Sciences Quarterly
Randa A Althobiti, Nausheen W Sadiq, Diane Beauchemin
Over 3 billion people share a diet consisting mainly of rice, which may contain significant amounts of arsenic. Because the toxicity of arsenic is dependent on its chemical form and that it may be in a form that is not bio-accessible (i.e. dissolved in the gastrointestinal tract) and can thus not become bio-available (i.e. end up in the blood stream, where it may exert its toxic effect), the bio-accessibility of arsenic was determined in thirteen different types of rice. The effects of washing and cooking were also studied...
August 15, 2018: Food Chemistry
Ibrar Khan, Bashir Ahmad, Sadiq Azam, Fida Hassan, - Nazish, Aamir Aziz, Noor Rehman, Farman Ullah, Zainab Liaqat
The current study focused on the pharmacological activities of Justicia adhatoda; including antibacterial, antifungal, phytotoxic, cytotoxic, haemagglutination, insecticidal, in vitro antiglycation, DPPH antioxidant and anti-termite. The crude methanolic extract (Crd. Met. Ext) showed 46.4 % antibacterial activity against M. morganii while the n-hexane fraction showed good (71.4%) and moderate (55.1%) activity against M. morganii and A. baumannii respectively. The EtOAc and aqueous fractions, in most of the cases, showed low to no activity against the selected bacterial pathogens, against A...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Sana Syed, Sunil Yeruva, Jeremy Herrmann, Anne Sailer, Kamran Sadiq, Najeeha Iqbal, Furqan Kabir, Kumail Ahmed, Shahida Qureshi, Sean R Moore, Jerrold Turner, S Asad Ali
Despite nutrition interventions, stunting thought to be secondary to underlying environmental enteropathy (EE) remains pervasive among infants residing in resource-poor countries and remains poorly characterized. From a birth cohort of 380 children, 65 malnourished infants received 12 weeks of nutritional supplementation with ready-to-use therapeutic food (RUTF). Eleven children with insufficient response to RUTF underwent upper endoscopy with duodenal biopsies, which were compared with U.S., age-matched specimens for healthy, celiac disease, non-celiac villous atrophy, non-celiac intraepithelial lymphocytosis, and graft-versus-host disease patients...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
Bernard Combe, Sadiq Lula, Caroline Boone, Patrick Durez
OBJECTIVES: To evaluate the effect of biologic disease-modifying anti-rheumatic drugs (bDMARDs) on radiographic progression in patients with rheumatoid arthritis (RA). METHODS: A systematic review of electronic databases and conference proceedings was conducted through January 2015, to identify randomised controlled trials (RCTs) and observational studies that assessed the impact of bDMARDs [± conventional synthetic DMARDs (csDMARDs), mainly methotrexate (MTX)], versus csDMARDs alone, on radiographic progression in patients with RA...
March 20, 2018: Clinical and Experimental Rheumatology
Alia Sadiq, Ahmed Shah, Marc G Jeschke, Cassandra Belo, Muhammad Qasim Hayat, Sheeba Murad, Saeid Amini-Nik
Post-burn trauma significantly raises tissue serotonin concentration at the initial stages of injury, which leads us to investigate its possible role in post burn wound healing. Therefore, we planned this study to examine the role of serotonin in wound healing through in vitro and in vivo models of burn injuries. Results from in vitro analysis revealed that serotonin decreased apoptosis and increased cell survival significantly in human fibroblasts and neonatal keratinocytes. Cellular proliferation also increased significantly in both cell types...
March 29, 2018: International Journal of Molecular Sciences
Muafia Jabeen, Sajjad Ahmad, Khadija Shahid, Abdul Sadiq, Umer Rashid
In thecurrent research work,eleven metal complexes were synthesized from the hydrazide derivative of ursolic acid. Metal complexes of tin, antimony and iron were synthesized and characterized by FT-IR and NMR spectroscopy. The antibacterial and antioxidant activities were performed for these complexes, which revealed that the metal complexes synthesized are more potent than their parent compounds. We observed that antioxidant activity showed by triphenyltin complex was significant and least activity have been shown by antimony trichloride complex...
2018: Frontiers in Chemistry
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