Christopher P King, Apurva S Chitre, Joel D Leal-Gutiérrez, Jordan A Tripi, Alesa R Hughson, Aidan P Horvath, Alexander C Lamparelli, Anthony George, Connor Martin, Celine L St Pierre, Hannah V Bimschleger, Jianjun Gao, Riyan Cheng, Khai-Minh Nguyen, Katie L Holl, Oksana Polesskaya, Keita Ishiwari, Hao Chen, Leah C Solberg Woods, Abraham A Palmer, Terry E Robinson, Shelly B Flagel, Paul J Meyer
Addiction vulnerability is associated with the tendency to attribute incentive salience to reward predictive cues; both addiction and the attribution of incentive salience are influenced by environmental and genetic factors. To characterize the genetic contributions to incentive salience attribution, we performed a genome-wide association study (GWAS) in a cohort of 1,645 genetically diverse heterogeneous stock (HS) rats. We tested HS rats in a Pavlovian conditioned approach task, in which we characterized the individual responses to food-associated stimuli ("cues")...
March 14, 2024: bioRxiv