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https://www.readbyqxmd.com/read/28938502/-alarming-pregabalin-abuse-in-munich-prevalence-patterns-of-use-and-complications
#1
Nicolas Zellner, Florian Eyer, Tobias Zellner
Background Pregabalin is used e. g. for the treatment of neuropathic pain and anxiety disorder. Recently, its potential for abuse and addiction has become apparent. Methods From 2008 - 2015, we searched our database for the term "Pregabalin", including all patients treated in our department and all calls to the Poison Information Centre (PIC) Munich.From October 2013 to September 2014, all patients were included in a cohort study who either were admitted with a drug intoxication or who presented themselves for a course of detoxification (except ethanol)...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28930051/addiction-and-the-role-of-circadian-genes
#2
Laura A Forde, Gursharan Kalsi
OBJECTIVE: In mammals, intimate interactions exist between the circadian system and other molecular systems, and mounting evidence is suggesting that these relationships may affect substance use disorders. Research in preclinical models supports the role of circadian genes as risk factors for addiction. Here, we explore the evidence and review human genetic studies testing the association between specific circadian genes and substance use disorders. METHOD: A literature search was conducted in PubMed for studies testing variants in eight circadian genes known to be central to the functioning of the master clock in the brain...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28921667/polysubstance-use-among-adolescents-in-a-low-income-rural-community-latent-classes-for-middle-and-high-school-students
#3
Roderick A Rose, Caroline B R Evans, Paul R Smokowski, Matthew O Howard, Katie L Stalker
PURPOSE: Rural communities are currently being impacted by a nationwide epidemic of prescription opioid misuse. Rural adolescent substance users may be at substantial risk for later addiction to these and other drugs. METHODS: This study uses Latent Class Analysis to identify subtypes of polysubstance users among a sample of 7,074 rural adolescents. Separate models were estimated for middle- and high-school youth. Predictive validity was estimated using cumulative ordinal logistic regression of the classes on a set of youth and family characteristics...
September 18, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28919445/cognitive-effects-of-labeled-addictolytic-medications
#4
REVIEW
Camille Noélie Pujol, Cecilia Paasche, Vincent Laprevote, Benoit Trojak, Pierre Vidailhet, Elisabeth Bacon, Laurence Lalanne
INTRODUCTION: Alcohol, tobacco, and illegal drug usage is pervasive throughout the world, and abuse of these substances is a major contributor to the global disease burden. Many pharmacotherapies have been developed over the last 50years to target addictive disorders. While the efficacy of these pharmacotherapies is largely recognized, their cognitive impact is less known. However, all substance abuse disorders are known to promote cognitive disorders like executive dysfunction and memory impairment...
September 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28911631/new-psychoactive-substances-of-natural-origin-a%C3%A2-brief-review
#5
REVIEW
Ling-Yi Feng, Altansuvd Battulga, Eunyoung Han, Heesun Chung, Jih-Heng Li
Plant-based drugs of abuse are as old as recorded human history. Although traditional addictive substances, such as opium, cannabis and coca, have been controlled by the United Nations anti-drug conventions, many, if not most, natural plants with addictive or abuse liability remain elusive. Therefore, the United Nations Office on Drugs and Crime (UNODC) has warned the emerging threat from new psychoactive substances (NPS), which are mostly derived or modified from the constituents of natural origin. For example, synthetic cannabinoids and synthetic cathinones are derived from the cannabis and khat plant, respectively...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28894784/blood-lead-levels-in-asymptomatic-opium-addict-patients-a-case-control-study
#6
Kazem Ghaemi, Atefeh Ghoreishi, Navid Rabiee, Samira Alinejad, Esmaeil Farzaneh, Alireza Amirabadi Zadeh, Mohammad Abdollahi, Omid Mehrpour
INTRODUCTION: One of the newest non-occupational sources of lead contamination is drug addiction, which has recently been addressed as a major source of lead poisoning in some countries. The present study aimed to investigate the blood lead level (BLL) of asymptomatic opium addicts. METHODS: This case-control study was conducted during a one-year period to compare BLL of three groups consisting of opium addicts, patients under methadone maintenance therapy (MMT), and healthy individuals...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28894547/a-novel-therapy-for-cocaine-dependence-during-abstinence-a-randomized-clinical-trial
#7
Bijan Pirnia, Ali Reza Moradi, Kambiz Pirnia, Parisa Kolahi, Rasool Roshan
BACKGROUND: Topiramate is an anticonvulsant drug and an ideal candidate for reducing the craving in people relying on cocaine. Contingency management is one of the common therapies in the domain of addiction. OBJECTIVE: The present study aimed to evaluate and compare three medication methods of Topiramate (TPM), Contingency Management (CM) and the combined TPM treatment and cash intervention on craving during abstinence. METHODS: This randomized clinical trial was conducted at Bijan Center for Substance Abuse Treatment in Tehran, Iran, from December 15, 2014 to November 20, 2015...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28892721/glial-and-neuroinflammatory-targets-for-treating-substance-use-disorders
#8
REVIEW
Ryan K Bachtell, Jermaine D Jones, Keith G Heinzerling, Patrick M Beardsley, Sandra D Comer
BACKGROUND: The plenary session at the 2016 Behavior, Biology and Chemistry: Translational Research in Addiction Conference focused on glia as potential players in the development, persistence and treatment of substance use disorders. Glia partake in various functions that are important for healthy brain activity. Drugs of abuse alter glial cell activity producing several perturbations in brain function that are thought to contribute to behavioral changes associated with substance use disorders...
August 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28879662/setting-research-priorities-in-tobacco-control-a-stakeholder-engagement-project
#9
REVIEW
Nicola Lindson, Dan Richards-Doran, Laura Heath, Jamie Hartmann-Boyce
BACKGROUND AND AIMS: The Cochrane Tobacco Addiction Group (TAG) conducts systematic reviews of the evidence for tobacco cessation and prevention interventions. In 2016 TAG conducted a priority-setting, stakeholder engagement project to identify where further research is needed in the areas of tobacco control and smoking cessation. DESIGN: The project comprised two surveys and a workshop. A range of stakeholders participated, including members of the public (smokers and ex-smokers), clinicians, researchers, research funders, health-care commissioners and public health organizations...
September 6, 2017: Addiction
https://www.readbyqxmd.com/read/28865800/the-role-of-continuing-medical-education-in-increasing-enrollment-in-prescription-drug-monitoring-programs
#10
John T Finnell, Robert K Twillman, Stephanie A Breslan, Jan Schultz, Lyerka Miller
PURPOSE: Opioid diversion, misuse, and abuse are rapidly growing problems in the United States; >60% of all drug overdose deaths involve an opioid. At least 49 states now have fully operational prescription drug monitoring programs (PDMPs) to support legitimate medical use of controlled substances; however, there is considerable underutilization of such programs. METHODS: To increase awareness of PDMPs and their use, a continuing medical education program including 2 webcasts and a series of newsletters was offered to health care providers...
August 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28863054/topics-of-addiction-in-turkish-nursing-programs-a-summary
#11
Candan Ozturk, Dijle Ayar, Burcu Arkan, Merry Armstrong Fougere
Addiction is a serious health issue. The measured rates of substance abuse in Turkey are lower than those in Western countries; however, recent studies show a significant increase in the prevalence of substance abuse and that the age of onset of substance abuse has decreased. There is a lack of literature about the topic of addiction in the undergraduate nursing programs in Turkey. Therefore, the aim of this current study was to examine the presence of addiction content in nursing education in Turkey among state and foundation universities...
July 2017: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/28863051/developing-an-addictions-nursing-competency-framework-within-a-canadian-context
#12
Sara Ling, Alison Watson, Margaret Gehrs
Clients with substance use disorders access care in all areas of the health care system, yet the Canadian nursing literature lacks content on the knowledge, skills, and judgment needed by nurses who work with this population. To address this literature gap, two Advanced Practice Nurses adapted the Canadian Centre on Substance Abuse's Technical Competencies for Canada's Substance Abuse Workforce to include nursing content and theory. This article describes the adaptation process and validation method used by the Advanced Practice Nurses at a large, Canadian urban teaching hospital and includes discussion about actual and potential opportunities for practical application of the adapted framework...
July 2017: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/28859162/foods-are-differentially-associated-with-subjective-effect-report-questions-of-abuse-liability
#13
Erica M Schulte, Julia K Smeal, Ashley N Gearhardt
OBJECTIVES: The current study investigates which foods may be most implicated in addictive-like eating by examining how nutritionally diverse foods relate to loss of control consumption and various subjective effect reports. Subjective effect reports assess the abuse liabilities of substances and may similarly provide insight into which foods may be reinforcing in a manner that triggers an addictive-like response for some individuals. DESIGN: Cross-sectional. SETTING: Online community...
2017: PloS One
https://www.readbyqxmd.com/read/28852236/felt-need-and-treatment-seeking-barriers-among-substance-abusers-in-urban-slum-area-in-central-india
#14
Himanshu Jayantrao Ashtankar, Manoj Rajanna Talapalliwar
INTRODUCTION: Substance abuse is known public health problem in the world. Felt need of treatment and barriers in seeking treatment are important for successful treatment of addictions. Therefore, this study was designed to understand the pattern (type) of substance abuse among residents of urban slum and to study the felt need and barriers for the treatment of substance abuse among substance abusers in urban slum areas of the central India. MATERIALS AND METHODS: A community-based cross-sectional study was conducted in slum area in central India...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28846941/incremental-predictive-validity-of-the-addiction-severity-index-psychiatric-composite-score-in-a-consecutive-cohort-of-patients-in-residential-treatment-for-drug-use-disorders
#15
Birgitte Thylstrup, Kim Bloomfield, Morten Hesse
BACKGROUND: The Addiction Severity Index (ASI) is a widely used assessment instrument for substance abuse treatment that includes scales reflecting current status in seven potential problem areas, including psychiatric severity. The aim of this study was to assess the ability of the psychiatric composite score to predict suicide and psychiatric care after residential treatment for drug use disorders after adjusting for history of psychiatric care. METHODS: All patients treated for drug use disorders in residential treatment centers in Denmark during the years 2000-2010 with complete ASI data were followed through national registers of psychiatric care and causes of death (N=5825)...
August 22, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28841113/pharmacoepigenomics-of-opiates-and-methadone-maintenance-treatment-current-data-and-perspectives
#16
Cynthia Marie-Claire, Clément Jourdaine, Jean-Pierre Lépine, Frank Bellivier, Vanessa Bloch, Florence Vorspan
Current treatments of opioid addiction include primarily maintenance medications such as methadone. Chronic exposure to opiate and/or long-lasting maintenance treatment induce modulations of gene expression in brain and peripheral tissues. There is increasing evidence that epigenetic modifications underlie these modulations. This review summarizes published results on opioid-induced epigenetic changes in animal models and in patients. The epigenetic modifications observed with other drugs of abuse often used by opiate abusers are also outlined...
September 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28839515/addictive-behaviors-in-liver-transplant-recipients-the-real-problem
#17
REVIEW
Hélène Donnadieu-Rigole, Pascal Perney, José Ursic-Bedoya, Stéphanie Faure, Georges-Philippe Pageaux
Liver transplantation (LT) is the gold standard treatment for end-stage liver disease. Whatever the primary indication of LT, substance abuse after surgery may decrease survival rates and quality of life. Prevalence of severe alcohol relapse is between 11 and 26%, and reduces life expectancy regardless of the primary indication of LT. Many patients on waiting lists for LT are smokers and this is a major risk factor for both malignant tumors and cardiovascular events post-surgery. The aim of this review is to describe psychoactive substance consumption after LT, and to assess the impact on liver transplant recipients...
August 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28835408/sugar-addiction-is-it-real-a-narrative-review
#18
REVIEW
James J DiNicolantonio, James H O'Keefe, William L Wilson
In animal studies, sugar has been found to produce more symptoms than is required to be considered an addictive substance. Animal data has shown significant overlap between the consumption of added sugars and drug-like effects, including bingeing, craving, tolerance, withdrawal, cross-sensitisation, cross-tolerance, cross-dependence, reward and opioid effects. Sugar addiction seems to be dependence to the natural endogenous opioids that get released upon sugar intake. In both animals and humans, the evidence in the literature shows substantial parallels and overlap between drugs of abuse and sugar, from the standpoint of brain neurochemistry as well as behaviour...
August 23, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28832888/american-indian-and-white-adoptees-are-there-mental-health-differences
#19
Ashley L Landers, Sharon M Danes, Kate Ingalls-Maloney, Sandy White Hawk
Adult adoptees are at increased risk for mental health problems compared to nonadoptees. However, little is known about subsets of adoptees that may be more or less vulnerable to mental health problems. The purpose of this study was to explore the presence of mental health problems of American Indian (AI) persons compared to White persons who were separated from their birth families during childhood by foster care and/or adoption. Family systems theory guided the study. AI adoptees reported higher percentages of problems than White adoptees on all mental health problems measures (e...
2017: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
https://www.readbyqxmd.com/read/28826746/the-prevalence-of-food-addiction-in-a-large-sample-of-adolescents-and-its-association-with-addictive-substances
#20
Gabry W Mies, Jorien L Treur, Junilla K Larsen, Jutka Halberstadt, Joëlle A Pasman, Jacqueline M Vink
The prevalence of overweight and obesity is increasing, due to, among other factors, increased availability of highly palatable food (food high in fat, salt and/or sugar). It has been proposed that certain foods and/or eating behaviours may be addictive, to a degree comparable to substances of abuse. The Yale Food Addiction Scale (YFAS) measures 'food addiction' by translating the diagnostic criteria for substance use disorder to eating behaviour. So far, only a few studies have examined the prevalence of food addiction in children with the YFAS for children (YFAS-C)...
August 4, 2017: Appetite
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