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Roy M John, Sunil Kapur, Kenneth A Ellenbogen, Jayanthi N Koneru
BACKGROUND: Collateral damage has been reported with the use of the cryoballon for pulmonary vein isolation. OBJECTIVES: To determine the incidence and characteristics associated with atrioesophageal fistula (AEF) following the use of cryoballoon. METHODS: Cases of AEF reported with the cryoballoon since 2011 were collected from the MAUDE database, publications and the manufacturer's database. Lowest balloon temperatures were compared with matched control patients undergoing cryoballoon ablation without AEF formation...
October 18, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Tetsuo Yamaguchi, Takamichi Miyamoto, Takamasa Iwai, Junji Yamaguchi, Sadahiro Hijikata, Ryoichi Miyazaki, Naoyuki Miwa, Masahiro Sekigawa, Nobuhiro Hara, Yasutoshi Nagata, Toshihiro Nozato, Yasuteru Yamauchi, Toru Obayashi, Mitsuaki Isobe
BACKGROUND: The prognosis of super-elderly patients (age≥85 years) who undergo bradycardia pacemaker (PM) implantation remains unknown. METHODS: We retrospectively enrolled 868 patients (men 49.0%, 76.6±10.6 years) who could walk unassisted and whose expected life expectancy was more than 1 year, receiving their first bradycardia PM implantation between January 1, 2006, and June 30, 2013. Clinical outcomes were compared between super-elderly patients (n=201, mean age 88...
October 15, 2016: Journal of Cardiology
Joachim Alexandre, Xavier Humbert, Marion Sassier, Paul Milliez, Antoine Coquerel, Sophie Fedrizzi
Cluster headache (CH) is a primary headache disorder with relatively effective treatments. Although few sufficiently controlled trials are available, verapamil is recommended as the first-line prophylactic drug for CH by the French Headache Society (with a low level of evidence, level B) and by the EFNS (European Federation of Neurological Societies, level A). Daily doses of more than 480 mg (and up to 1200 mg daily) are frequently used off-label, while 360 mg daily is the only dosage to have demonstrated its effectiveness in a double-blind trial against placebo, and the usual label posology used by cardiologists is 240 mg daily in hypertension...
December 2015: Drug Saf Case Rep
Daniel Romero, Oscar Camara, Frank Sachse, Rafael Sebastian
The specialised conducting tissues present in the ventricles are responsible for the fast distribution of the electrical impulse from the atrio-ventricular node to regions in the subendocardial myocardium. Characterisation of anatomical features of the specialised conducting tissues in the ventricles is highly challenging, in particular its most distal section, which is connected to the working myocardium via Purkinje-myocardial junctions. The goal of this work is to characterise the architecture of the distal section of the Purkinje network by differentiating Purkinje cells from surrounding tissue, performing a segmentation of Purkinje fibres at cellular scale, and mathematically describing its morphology and interconnections...
2016: PloS One
Paolo Piras, Concetta Torromeo, Federica Re, Antonietta Evangelista, Stefano Gabriele, Giuseppe Esposito, Paola Nardinocchi, Luciano Teresi, Andrea Madeo, Claudia Chialastri, Michele Schiariti, Valerio Varano, Massimo Uguccioni, Paolo E Puddu
The analysis of full Left Atrium (LA) deformation and whole LA deformational trajectory in time has been poorly investigated and, to the best of our knowledge, seldom discussed in patients with Hypertrophic Cardiomyopathy. Therefore, we considered 22 patients with Hypertrophic Cardiomyopathy (HCM) and 46 healthy subjects, investigated them by three-dimensional Speckle Tracking Echocardiography, and studied the derived landmark clouds via Geometric Morphometrics with Parallel Transport. Trajectory shape and trajectory size were different in Controls versus HCM and their classification powers had high AUC (Area Under the Receiving Operator Characteristic Curve) and accuracy...
October 7, 2016: Scientific Reports
Oscar Palmér, Kenneth Palmér, Jan Hultman, Mikael Broman
Extracorporeal membrane oxygenation (ECMO) is used as a lifesaving rescue treatment in refractory respiratory and/or cardiac failure. During veno-venous (VV) ECMO the presence of recirculation is known but quantification and actions to minimize recirculation following measurement are to date not routinely practiced. In the present study we investigated the effect of draining cannula design on recirculation fraction (Rf) during VV ECMO; Conventional mesh cannula was compared to a Multi-stage cannula. The effect of adjusting cannula position was also studied...
September 20, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Ehud Chorin, Aviram Hochstadt, Sami Viskin, Uri Rozovski, Ofer Havakuk, Adrian Baranchuk, Andres Enriquez, Boris Strasberg, Milton E Guevara-Valdivia, Manlio F Márquez, Héctor González-Pacheco, Can Hasdemir, Raphael Rosso
BACKGROUND: Female gender increases the risk of torsades de pointes (TdP) in the long QT syndrome, and this increased risk is assumed to be due to their longer QT interval. OBJECTIVE: The purpose of this study was to study the interplay between gender, duration of the QT interval, and risk of TdP during AV block. METHODS: We studied 250 patients (48% women) with AV block. QT interval was measured at the time of most severe bradycardia. We then constructed different receiver operating characteristic curves for the QTc of males and females for predicting TdP...
September 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Venkatraman Bhat, Vinay Belaval, Karthik Gadabanahalli, Vimal Raj, Sejal Shah
From the stand point of radiographic analysis most of the complex cyanotic congenital heart diseases (CHD), can be divided into those associated with decreased or increased pulmonary vascularity. Combination of a specific cardiac configuration and status of lung vasculature in a clinical context allows plain film diagnosis to be predicted in some CHD. Correlation of the position of the cardiac apex in relation to the visceral situs is an important information that can be obtained from the plain film. This information helps in gathering information about the atrio-ventricular, ventricular arterial concordance or discordance...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Hakan Ozkan, Suleyman Binici, Erhan Tenekecioglu, Hasan Ari, Tahsin Bozat
Background: Atrial fibrillation (AF) is the most common arrhythmia seen in adults. Atrial stunning is defined as the temporary mechanical dysfunction of the atrial appendage developing after AF has returned to sinus rhythm (SR). Objectives: We aimed to evaluate atrial contractile functions by strain and strain rate in patients with AF, following pharmacological and electrical cardioversion and to compare it with conventional methods. Methods: This study included 41 patients with persistent AF and 35 age-matched control cases with SR...
September 12, 2016: Arquivos Brasileiros de Cardiologia
Heidi L Lujan, Joshua P Rivers, Stephen E DiCarlo
Mice may now be the preferred animal model for biomedical research due to its anatomical, physiological, and genetic similarity to humans. However, little is known about accentuated antagonism of chronotropic and dromotropic properties in conscious mice. Accordingly, we describe the complex and interacting influence of the autonomic nervous system on cardiac electrophysiology in conscious mice. Specifically, we report the effects of single and combined cardiac autonomic blockade on measurements of pulse interval (heart rate), atrio-ventricular interval, sinus node recovery time (SNRT), SNRT corrected for spontaneous sinus cycle, and Wenckebach cycle length in conscious mice free of the confounding influences of anesthetics and surgical trauma...
August 29, 2016: Autonomic Neuroscience: Basic & Clinical
T Cools, T Daerden, L Herbots, R Geukens, J Verwerft, P Koopman, D Dilling-Boer, D Hansen, P Vranckx, P Dendale
No abstract text is available yet for this article.
June 2016: Acta Cardiologica
Kar-Lai Poon, Michael Liebling, Igor Kondrychyn, Thomas Brand, Vladimir Korzh
The cardiac conduction system (CCS) propagates and coordinates the electrical excitation that originates from the pacemaker cells, throughout the heart, resulting in rhythmic heartbeat. Its defects result in life-threatening arrhythmias and sudden cardiac death. Understanding of the factors involved in the formation and function of the CCS remains incomplete. By transposon assisted transgenesis, we have developed enhancer trap (ET) lines of zebrafish that express fluorescent protein in the pacemaker cells at the sino-atrial node (SAN) and the atrio-ventricular region (AVR), termed CCS transgenics...
July 2016: Gene Expression Patterns: GEP
Agnieszka Mlynarska, Rafal Mlynarski, Krzysztof S Golba
AIM: To assess the prevalence of frailty syndrome in patients with heart rhythm disorders that qualified for pacemaker implantation. METHODS: The study included 171 patients (83 women, aged 73.9 ± 6.7 years) who qualified for pacemaker implantation as a result of sinus node dysfunction (81 patients) or atrio-ventricular blocks (AVB; 90 patients). A total of 60 patients (25 women, aged 72.40 ± 7.09 years) without heart rhythm disorders were included in the control group...
August 25, 2016: Geriatrics & Gerontology International
Swapnalee Sarmah, Pooja Muralidharan, James A Marrs
Fetal alcohol spectrum disorder (FASD), birth defects associated with ethanol exposure in utero, includes a wide spectrum of congenital heart defects (CHDs), the most prevalent of which are septal and conotruncal defects. Zebrafish FASD model was used to dissect the mechanisms underlying FASD-associated CHDs. Embryonic ethanol exposure (3-24 hours post fertilization) led to defects in atrio-ventricular (AV) valvulogenesis beginning around 37 hpf, a morphogenetic event that arises long after ethanol withdrawal...
2016: PloS One
Chao Zhang, Yongquan Gu, Ce Bian, Guangchang Zhu, Tao Luo, Chao Yan, Zhonggao Wang
Budd-Chiari syndrome (BCS) is a rare hepatic disease caused by occlusion of the hepatic venous outflow at any level from the small hepatic veins to the atrio-cava junction. BCS could have serious consequences if not treated promptly. The appropriate therapeutic strategy can be offered to change the natural course of the disease. The present case reports a young man with BCS who was successfully received the hybrid treatment combined with endovascular intervention and mesocaval shunt by step. The 11-year follow-up showed that the patient was free of clinical symptoms, CT and ultrasonography confirmed the patency of the stent and shunt...
August 20, 2016: Annals of Vascular Surgery
Nuno Almeida, Alexandros Papachristidis, Peter Pearson, Sebastian Imre Sarvari, Jan Engvall, Thor Edvardsen, Mark Monaghan, Olivier Gérard, Eigil Samset, Jan D'hooge
AIMS: This study aims at validating a software tool for automated segmentation and quantification of the left atrium (LA) from 3D echocardiography. METHODS AND RESULTS: The LA segmentation tool uses a dual-chamber model of the left side of the heart to automatically detect and track the atrio-ventricular plane and the LA endocardium in transthoracic 3D echocardiography. The tool was tested in a dataset of 121 ultrasound images from patients with several cardiovascular pathologies (in a multi-centre setting), and the resulting volumes were compared with those assessed manually by experts in a blinded analysis using conventional contouring...
August 22, 2016: European Heart Journal Cardiovascular Imaging
Asit Das, Dhiman Kahali
Adverse hemodynamics of right ventricular (RV) pacing is a well-known fact. It was believed to be the result of atrio-ventricular (AV) dyssynchrony and sequential pacing of the atrium and ventricle may solve these problems. However, despite maintenance of AV synchrony, the dual chamber pacemakers in different trials have failed to show its superiority over single chamber RV apical pacing in terms of death, progression of heart failure, and atrial fibrillation (AF). As a consequence, investigators searched for alternate pacing sites with a more physiological activation pattern and better hemodynamics...
July 2016: Indian Heart Journal
Benjamin J Scherlag, Ralph Lazzara
In this review we present evidence from many experimental studies which challenge the concept of predestination of His bundle fibers. Using both intra- and extracellular His bundle pacing in the context of atrio-ventricular block and the development of bundle branch blocks these experimental studies provide the underlying mechanisms for the recent clinical findings showing the benefits of permanent His bundle pacing.
July 16, 2016: Journal of Electrocardiology
Michael Yeong, Radwa Bedair, Andreas Baumbach, Massimo Caputo, Nathan Manghat, Mark Turner
No abstract text is available yet for this article.
November 1, 2016: International Journal of Cardiology
Laura L Reimers, Supriya D Mehta, L Stewart Massad, Robert D Burk, Xianhong Xie, Jacques Ravel, Mardge H Cohen, Joel M Palefsky, Kathleen Weber, Xiaonan Xue, Kathryn Anastos, Howard Minkoff, Jessica Atrio, Gypsyamber D'Souza, Qian Ye, Christine Colie, Christine P Zolnik, Gregory T Spear, Howard D Strickler
BACKGROUND:  Bacterial vaginosis (BV) is characterized by low abundance of Lactobacillus spp., high pH, immune cell infiltration, and has been associated with increased risk of human papillomavirus (HPV) infection. We molecularly assessed the cervicovaginal microbiota over time in HIV-infected and HIV-uninfected women to more comprehensively study the HPV-microbiota relationship, controlling for immune status. METHODS:  16S rRNA gene amplicon pyrosequencing and HPV DNA testing was conducted annually in serial cervicovaginal lavage specimens obtained over 8-10 years in African American women from Chicago: (i) N=22 HIV-uninfected, (ii) N=22 HIV-infected with stable CD4 >500 cells/mm(3), (iii) N=20 HIV-infected women with progressive immunosuppression...
August 11, 2016: Journal of Infectious Diseases
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