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JOURNAL ARTICLE
M Majstorovic, A Chur-Hansen, J M Andrews, A L J Burke
Bariatric surgery is an effective treatment for severe obesity, affording significant improvements in weight loss and health-related quality of life. However, bariatric surgeons' views on whether certain pre-operative factors predict improvements in post-operative health-related quality of life, and if so, which ones, are largely unknown. This cross-sectional survey study examined the views of 58 bariatric surgeons from Australia and New Zealand. A total of 18 factors were selected for exploration based on their mention in the literature...
April 20, 2024: Clinical Obesity
#22
JOURNAL ARTICLE
Ana Maria Cuervo, Zvulun Elazar, Chantell Evans, Liang Ge, Malene Hansen, Marja Jäättelä, Jin Rui Amos Liang, Ben Loos, Noboru Mizushima, Anna Katharina Simon, Sharon Tooze, Tamotsu Yoshimori, Shuhei Nakamura
No abstract text is available yet for this article.
April 19, 2024: Nature Cell Biology
#23
EDITORIAL
Jennette Hansen, Elizabeth Cotter
No abstract text is available yet for this article.
April 9, 2024: Journal of Cardiothoracic and Vascular Anesthesia
#24
JOURNAL ARTICLE
Tomas Slåtten Nenningsland, Babak Asadi-Azarbaijani, Hanne Birgit Alfheim, Elisabeth Holm Hansen
PURPOSE: The purpose of this study is to explore factors influencing sleep in pediatric intensive care units as perceived by parents of critically ill children. DESIGN AND METHODS: This descriptive qualitative study used individual semistructured interviews. Parents were recruited through purposive sampling from two pediatric intensive care units at two locations in one university hospital in Norway. Ten parents were interviewed. The interviews were analyzed using a six-phase reflexive thematic analysis...
April 18, 2024: Journal of Pediatric Nursing
#25
JOURNAL ARTICLE
Ole Abildgaard Hansen, Jane Clemensen, Christoph P Beier, Gry Pors Klinting, Anthony C Smith, Malene Kaas Larsen
BACKGROUND: The transition from pediatric to adult care is challenging for adolescent patients despite numerous recommendations in recent decades. However, the perspective of the patients is sparsely investigated. AIM: To explore the experiences and needs of adolescents with epilepsy (AWE) during the transition from pediatric to adult hospital care. METHODS: We conducted 15 semi-structured interviews with AWEs aged 13-20 years and 10 h of field observations of consultations...
April 18, 2024: Epilepsy & Behavior: E&B
#26
JOURNAL ARTICLE
Lorenzo Carosini, Virginia Oddi, Francesco Giorgino, Lena M Hansen, Benoit Seron, Simone Piacentini, Tobias Guggemos, Iris Agresti, Juan C Loredo, Philip Walther
The interference of nonclassical states of light enables quantum-enhanced applications reaching from metrology to computation. Most commonly, the polarization or spatial location of single photons are used as addressable degrees of freedom for turning these applications into praxis. However, the scale-up for the processing of a large number of photons of these architectures is very resource-demanding due to the rapidly increasing number of components, such as optical elements, photon sources, and detectors...
April 19, 2024: Science Advances
#27
JOURNAL ARTICLE
Nina Strandkjær, Nicoline Jørgensen, Rasmus Bo Hasselbalch, Jonas Kristensen, Marie Sophie Sander Knudsen, Thilde Olivia Kock, Theis Lange, Matias Greve Lindholm, Niels Eske Bruun, Lene Holmvang, Christian Juhl Terkelsen, Claus Kjær Pedersen, Martin Kirk Christensen, Jens Flensted Lassen, Linda Hilsted, Søren Ladefoged, Mads Nybo, Mustafa Vakur Bor, Morten Dahl, Annebirthe Bo Hansen, Pia Rørbæk Kamstrup, Henning Bundgaard, Christian Torp-Pedersen, Kasper Karmark Iversen
BACKGROUND: Cardiac troponins are the preferred biomarkers for the diagnosis of acute myocardial infarction. Although sex-specific 99th percentile thresholds of troponins are recommended in international guidelines, the clinical effect of their use is poorly investigated. The DANSPOT Study (The Danish Study of Sex- and Population-Specific 99th percentile upper reference limits of Troponin) aims to evaluate the clinical effect of a prospective implementation of population- and sex-specific diagnostic thresholds of troponins into clinical practice...
April 19, 2024: Journal of the American Heart Association
#28
JOURNAL ARTICLE
Lisette A P Krassenburg, Raoel Maan, Amy Puenpatom, Nicole S Erler, Christoph Welsch, Stijn van Hees, Orlando Cerrhoci, Johannes Vermehren, Robert J de Knegt, Bettina E Hansen, Stefan Zeuzem, Thomas Vanwolleghem, Harry L A Janssen, Robert A de Man, Jordan J Feld, Adriaan J van der Meer
BACKGROUND AND AIMS: Historical paired liver biopsy studies are likely to underestimate current progression of disease in patients with chronic hepatitis C virus (HCV) infection. We aimed to assess liver disease progression according to the non-invasive Fibrosis-4 (FIB-4) index in patients with chronic HCV and early disease. METHODS AND RESULTS: Patients diagnosed with chronic HCV and FIB-4 <3.25 from four international liver clinics were included in a retrospective cohort study...
December 7, 2023: BMJ Open Gastroenterology
#29
JOURNAL ARTICLE
Adriana M Coletta, Lea Haverbeck Simon, Kelsey Maslana, Sarah Taylor, Kish Larson, Pamela A Hansen, Vinay Mathew Thomas, Cornelia M Ulrich, Manish Kohli, Jonathan Chipman, Umang Swami, Sumati Gupta, Benjamin L Maughan, Neeraj Agarwal
BACKGROUND: Muscle mass is important for metastatic prostate cancer survival and quality of life (QoL). The backbone of treatment for men with metastatic castration sensitive prostate cancer (mCSPC) is androgen deprivation therapy (ADT) with an androgen signaling inhibitor. ADT is an effective cancer treatment, but it facilitates significant declines in muscle mass and adverse health outcomes important to mCSPC survivors, such as fatigue, and reductions in physical function, independence, insulin sensitivity, and QoL...
April 18, 2024: BMC Cancer
#30
JOURNAL ARTICLE
Sinne Søberg Brun, Torben Frøstrup Hansen, Sara Witting Christensen Wen, Christa Haugaard Nyhus, Lisbeth Bertelsen, Anders Jakobsen, Torben Schjødt Hansen, Line Nederby
Many studies have focused on the prognostic role of soluble programmed death ligand 1 (sPD-L1) in non-small cell lung cancer (NSCLC), but outcomes are ambiguous and further investigations are needed. We addressed the matter by studying sPD-L1 in baseline samples and in longitudinal samples taken prior to three subsequent cycles of anti-PD-1/anti-PD-L1 treatments. Eighty patients with NSCLC were enrolled. Median sPD-L1 level at baseline was 52 pg/mL [95% confidence interval (CI) 49-57]. In patients treated with pembrolizumab and nivolumab, the concentration of sPD-L1 remained rather stable throughout treatment...
April 18, 2024: Scientific Reports
#31
JOURNAL ARTICLE
Caroline M Nievergelt, Adam X Maihofer, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan R I Coleman, Nikolaos P Daskalakis, Laramie E Duncan, Renato Polimanti, Cindy Aaronson, Ananda B Amstadter, Soren B Andersen, Ole A Andreassen, Paul A Arbisi, Allison E Ashley-Koch, S Bryn Austin, Esmina Avdibegoviç, Dragan Babić, Silviu-Alin Bacanu, Dewleen G Baker, Anthony Batzler, Jean C Beckham, Sintia Belangero, Corina Benjet, Carisa Bergner, Linda M Bierer, Joanna M Biernacka, Laura J Bierut, Jonathan I Bisson, Marco P Boks, Elizabeth A Bolger, Amber Brandolino, Gerome Breen, Rodrigo Affonseca Bressan, Richard A Bryant, Angela C Bustamante, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Anders D Børglum, Sigrid Børte, Leah Cahn, Joseph R Calabrese, Jose Miguel Caldas-de-Almeida, Chris Chatzinakos, Sheraz Cheema, Sean A P Clouston, Lucía Colodro-Conde, Brandon J Coombes, Carlos S Cruz-Fuentes, Anders M Dale, Shareefa Dalvie, Lea K Davis, Jürgen Deckert, Douglas L Delahanty, Michelle F Dennis, Frank Desarnaud, Christopher P DiPietro, Seth G Disner, Anna R Docherty, Katharina Domschke, Grete Dyb, Alma Džubur Kulenović, Howard J Edenberg, Alexandra Evans, Chiara Fabbri, Negar Fani, Lindsay A Farrer, Adriana Feder, Norah C Feeny, Janine D Flory, David Forbes, Carol E Franz, Sandro Galea, Melanie E Garrett, Bizu Gelaye, Joel Gelernter, Elbert Geuze, Charles F Gillespie, Slavina B Goleva, Scott D Gordon, Aferdita Goçi, Lana Ruvolo Grasser, Camila Guindalini, Magali Haas, Saskia Hagenaars, Michael A Hauser, Andrew C Heath, Sian M J Hemmings, Victor Hesselbrock, Ian B Hickie, Kelleigh Hogan, David Michael Hougaard, Hailiang Huang, Laura M Huckins, Kristian Hveem, Miro Jakovljević, Arash Javanbakht, Gregory D Jenkins, Jessica Johnson, Ian Jones, Tanja Jovanovic, Karen-Inge Karstoft, Milissa L Kaufman, James L Kennedy, Ronald C Kessler, Alaptagin Khan, Nathan A Kimbrel, Anthony P King, Nastassja Koen, Roman Kotov, Henry R Kranzler, Kristi Krebs, William S Kremen, Pei-Fen Kuan, Bruce R Lawford, Lauren A M Lebois, Kelli Lehto, Daniel F Levey, Catrin Lewis, Israel Liberzon, Sarah D Linnstaedt, Mark W Logue, Adriana Lori, Yi Lu, Benjamin J Luft, Michelle K Lupton, Jurjen J Luykx, Iouri Makotkine, Jessica L Maples-Keller, Shelby Marchese, Charles Marmar, Nicholas G Martin, Gabriela A Martínez-Levy, Kerrie McAloney, Alexander McFarlane, Katie A McLaughlin, Samuel A McLean, Sarah E Medland, Divya Mehta, Jacquelyn Meyers, Vasiliki Michopoulos, Elizabeth A Mikita, Lili Milani, William Milberg, Mark W Miller, Rajendra A Morey, Charles Phillip Morris, Ole Mors, Preben Bo Mortensen, Mary S Mufford, Elliot C Nelson, Merete Nordentoft, Sonya B Norman, Nicole R Nugent, Meaghan O'Donnell, Holly K Orcutt, Pedro M Pan, Matthew S Panizzon, Gita A Pathak, Edward S Peters, Alan L Peterson, Matthew Peverill, Robert H Pietrzak, Melissa A Polusny, Bernice Porjesz, Abigail Powers, Xue-Jun Qin, Andrew Ratanatharathorn, Victoria B Risbrough, Andrea L Roberts, Alex O Rothbaum, Barbara O Rothbaum, Peter Roy-Byrne, Kenneth J Ruggiero, Ariane Rung, Heiko Runz, Bart P F Rutten, Stacey Saenz de Viteri, Giovanni Abrahão Salum, Laura Sampson, Sixto E Sanchez, Marcos Santoro, Carina Seah, Soraya Seedat, Julia S Seng, Andrey Shabalin, Christina M Sheerin, Derrick Silove, Alicia K Smith, Jordan W Smoller, Scott R Sponheim, Dan J Stein, Synne Stensland, Jennifer S Stevens, Jennifer A Sumner, Martin H Teicher, Wesley K Thompson, Arun K Tiwari, Edward Trapido, Monica Uddin, Robert J Ursano, Unnur Valdimarsdóttir, Miranda Van Hooff, Eric Vermetten, Christiaan H Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Monika Waszczuk, Heike Weber, Frank R Wendt, Thomas Werge, Michelle A Williams, Douglas E Williamson, Bendik S Winsvold, Sherry Winternitz, Christiane Wolf, Erika J Wolf, Yan Xia, Ying Xiong, Rachel Yehuda, Keith A Young, Ross McD Young, Clement C Zai, Gwyneth C Zai, Mark Zervas, Hongyu Zhao, Lori A Zoellner, John-Anker Zwart, Terri deRoon-Cassini, Sanne J H van Rooij, Leigh L van den Heuvel, Murray B Stein, Kerry J Ressler, Karestan C Koenen
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new)...
April 18, 2024: Nature Genetics
#32
JOURNAL ARTICLE
Taryn Lores, Antonina Mikocka-Walus, Jane M Andrews, Subhadra Evans, Kate D Lynch, Anna Chur-Hansen
BACKGROUND: There is a need to improve psychological care for people with Inflammatory Bowel Diseases (IBD), noting the high psychosocial burden of disease. AIMS: This study qualitatively explored the views of people living with IBD to help inform future co-design of services that better meet the psychological needs of consumers. METHODS: Adults with IBD were recruited to attend virtual focus groups to discuss what they want most in an IBD-specific psychological service...
April 18, 2024: Digestive Diseases and Sciences
#33
JOURNAL ARTICLE
Ruta Zukauskaite Ruta, Morten Horsholt Kristensen, Jesper Grau Eriksen, Jørgen Johansen, Eva Samsøe, Lars Johnsen, Camilla Kjær Lønkvist, Cai Grau, Christian Rønn Hansen
INTRODUCTION: Treatment planning using a five-millimetre geometrical margin from GTV to high-dose CTV (CTV1) has been used in DAHANCA treatment centres since 2013. We aimed to evaluate changes in CTV1 volumes, local control (LC), and recurrence pattern after the implementation of five-millimetre geometrical margins nationally. MATERIALS AND METHODS: 1,948 patients with pharyngeal, and laryngeal squamous cell carcinomas completed definitive IMRT-based treatment in 2010-2012 and 2013-2015 in three centres...
April 16, 2024: Radiotherapy and Oncology
#34
JOURNAL ARTICLE
James K Fields, Elin Jaensson Gyllenbäck, Marek Bogacz, Juliet Obi, Gabriel Svensson Birkedal, Kjell Sjöström, Kino Maravillas, Caitríona Grönberg, Sara Rattik, Kyle Kihn, Maria Flowers, Ally K Smith, Nils Hansen, Thoas Fioretos, Chau Huyhn, David Liberg, Daniel Deredge, Eric J Sundberg
Interleukin-1 (IL-1)-family cytokines are potent modulators of inflammation, coordinating a vast array of immunological responses across innate and adaptive immune systems. Dysregulated IL-1-family cytokine signaling, however, is involved in a multitude of adverse health effects, such as chronic inflammatory conditions, autoimmune diseases, and cancer. Within the IL-1 family of cytokines, six-IL-1α, IL-1β, IL-33, IL-36α, IL-36β, and IL-36γ-require the IL-1 receptor accessory protein (IL-1RAcP) as their shared co-receptor...
April 11, 2024: Cell Reports
#35
JOURNAL ARTICLE
Juliana Goulart Prata Oliveira Milani, Mauricio Milani, Felipe Vilaça Cavallari Machado, Matthias Wilhelm, Thimo Marcin, Flavio D'Ascenzi, Luna Cavigli, Charly Keytsman, Maarten Falter, Bruno Bonnechere, Raf Meesen, Fabrício Braga, Graziella França Bernardelli Cipriano, Veronique Cornelissen, Kenneth Verboven, Gerson Cipriano Junior, Dominique Hansen
AIMS: To develop and validate equations predicting heart rate (HR) at the first and second ventilatory thresholds (VTs) and an optimized range-adjusted prescription for patients with cardiometabolic disease (CMD). To compare their performance against guideline-based exercise intensity domains. METHODS: Cross-sectional study involving 2,868 CMD patients from nine countries. HR predictive equations for first and second VTs (VT1, VT2) were developed using multivariate linear regression with 975 cycle-ergometer cardiopulmonary exercise tests (CPET)...
April 18, 2024: European Journal of Preventive Cardiology
#36
JOURNAL ARTICLE
Samuel A Bradley, Frederik G Hansson, Beata J Lehka, Daniela Rago, Pedro Pinho, Huadong Peng, Khem B Adhikari, Ahmad K Haidar, Lea G Hansen, Daria Volkova, Maxence Holtz, Sergi Muyo Abad, Xin Ma, Konstantinos Koudounas, Sébastien Besseau, Nicolas Gautron, Céline Mélin, Jillian Marc, Caroline Birer Williams, Vincent Courdavault, Emil D Jensen, Jay D Keasling, Jie Zhang, Michael K Jensen
Monoterpene indole alkaloids (MIAs) make up a highly bioactive class of metabolites produced by a range of tropical and subtropical plants. The corynanthe-type MIAs are a stereochemically complex subclass with therapeutic potential against a large number of indications including cancer, psychotic disorders, and erectile dysfunction. Here, we report yeast-based cell factories capable of de novo production of corynanthe-type MIAs rauwolscine, yohimbine, tetrahydroalstonine, and corynanthine. From this, we demonstrate regioselective biosynthesis of 4 fluorinated derivatives of these compounds and de novo biosynthesis of 7-chlororauwolscine by coexpression of a halogenase with the biosynthetic pathway...
April 18, 2024: ACS Synthetic Biology
#37
JOURNAL ARTICLE
Sufyan Suleman, Anne L Madsen, Lars H Ängquist, Mikkel Schubert, Allan Linneberg, Ruth J F Loos, Torben Hansen, Niels Grarup
CONTEXT: Insulin sensitivity (IS) is an important factor in type 2 diabetes (T2D) and can be estimated by many different indices. OBJECTIVE: We aimed to compare the genetic components underlying IS indices obtained from fasting and oral glucose-stimulated plasma glucose and serum insulin levels. METHODS: We computed 21 IS indices, classified as fasting, OGTT0,120 and OGTT0,30,120 indices, using fasting and oral glucose tolerance test (OGTT) data in two cohorts...
April 18, 2024: Journal of Clinical Endocrinology and Metabolism
#38
JOURNAL ARTICLE
Javier Sáez-Sáez, Lachlan Jake Munro, Iben Møller-Hansen, Douglas B Kell, Irina Borodina
Aromatic compounds are used in pharmaceutical, food, textile and other industries. Increased demand has sparked interest in exploring biotechnological approaches for their sustainable production as an alternative to chemical synthesis from petrochemicals or plant extraction. These aromatic products may be toxic to microorganisms, which complicates their production in cell factories. In this study, we analysed the toxicity of multiple aromatic compounds in common production hosts. Next, we screened a subset of toxic aromatics, namely 2-phenylethanol, 4-tyrosol, benzyl alcohol, berberine and vanillin, against transporter deletion libraries in Escherichia coli and Saccharomyces cerevisiae...
April 2024: Microbial Biotechnology
#39
JOURNAL ARTICLE
Annie Borch, Ibel Carri, Birkir Reynisson, Heli M Garcia Alvarez, Kamilla K Munk, Alessandro Montemurro, Nikolaj Pagh Kristensen, Siri A Tvingsholm, Jeppe Sejerø Holm, Christina Heeke, Keith Henry Moss, Ulla Kring Hansen, Anna-Lisa Schaap-Johansen, Frederik Otzen Bagger, Vinicius Araujo Barbosa de Lima, Kristoffer S Rohrberg, Samuel A Funt, Marco Donia, Inge Marie Svane, Ulrik Lassen, Carolina Barra, Morten Nielsen, Sine Reker Hadrup
BACKGROUND: Mutation-derived neoantigens are critical targets for tumor rejection in cancer immunotherapy, and better tools for neoepitope identification and prediction are needed to improve neoepitope targeting strategies. Computational tools have enabled the identification of patient-specific neoantigen candidates from sequencing data, but limited data availability has hindered their capacity to predict which of the many neoepitopes will most likely give rise to T cell recognition. METHOD: To address this, we make use of experimentally validated T cell recognition towards 17,500 neoepitope candidates, with 467 being T cell recognized, across 70 cancer patients undergoing immunotherapy...
2024: Frontiers in Immunology
#40
JOURNAL ARTICLE
S L Maes, J Dietrich, G Midolo, S Schwieger, M Kummu, V Vandvik, R Aerts, I H J Althuizen, C Biasi, R G Björk, H Böhner, M Carbognani, G Chiari, C T Christiansen, K E Clemmensen, E J Cooper, J H C Cornelissen, B Elberling, P Faubert, N Fetcher, T G W Forte, J Gaudard, K Gavazov, Z Guan, J Guðmundsson, R Gya, S Hallin, B B Hansen, S V Haugum, J-S He, C Hicks Pries, M J Hovenden, M Jalava, I S Jónsdóttir, J Juhanson, J Y Jung, E Kaarlejärvi, M J Kwon, R E Lamprecht, M Le Moullec, H Lee, M E Marushchak, A Michelsen, T M Munir, E M Myrsky, C S Nielsen, M Nyberg, J Olofsson, H Óskarsson, T C Parker, E P Pedersen, M Petit Bon, A Petraglia, K Raundrup, N M R Ravn, R Rinnan, H Rodenhizer, I Ryde, N M Schmidt, E A G Schuur, S Sjögersten, S Stark, M Strack, J Tang, A Tolvanen, J P Töpper, M K Väisänen, R S P van Logtestijn, C Voigt, J Walz, J T Weedon, Y Yang, H Ylänne, M P Björkman, J M Sarneel, E Dorrepaal
Arctic and alpine tundra ecosystems are large reservoirs of organic carbon1,2 . Climate warming may stimulate ecosystem respiration and release carbon into the atmosphere3,4 . The magnitude and persistency of this stimulation and the environmental mechanisms that drive its variation remain uncertain5-7 . This hampers the accuracy of global land carbon-climate feedback projections7,8 . Here we synthesize 136 datasets from 56 open-top chamber in situ warming experiments located at 28 arctic and alpine tundra sites which have been running for less than 1 year up to 25 years...
April 17, 2024: Nature
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