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https://www.readbyqxmd.com/read/29150966/current-policy-for-allocation-of-donor-livers-in-the-netherlands-advantages-primary-sclerosing-cholangitis-patients-on-the-liver-transplantation-waiting-list-a-retrospective-study
#1
Jorn C Goet, Bettina E Hansen, Madelon Tieleman, Bart van Hoek, Aad P van den Berg, Wojciech G Polak, Jeroen Dubbeld, Robert J Porte, Cynthia Konijn, Robert A de Man, Herold J Metselaar, Annemarie C de Vries
Studies from the United States and Nordic countries indicate primary sclerosing cholangitis (PSC) patients have low mortality on the liver transplantation (LTx) waiting list. However, this may vary among geographical areas. Therefore, we compared waiting list mortality and post-transplant survival between Laboratory Model for End Stage Liver Disease (LM) and MELD Exception (ME) prioritized PSC and non-PSC candidates in a nationwide study in the Netherlands. A retrospective analysis of patients waitlisted from 2006 to 2013 was conducted...
November 18, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29150562/the-role-of-mhc-e-in-t-cell-immunity-is-conserved-among-humans-rhesus-macaques-and-cynomolgus-macaques
#2
Helen L Wu, Roger W Wiseman, Colette M Hughes, Gabriela M Webb, Shaheed A Abdulhaqq, Benjamin N Bimber, Katherine B Hammond, Jason S Reed, Lina Gao, Benjamin J Burwitz, Justin M Greene, Fidel Ferrer, Alfred W Legasse, Michael K Axthelm, Byung S Park, Simon Brackenridge, Nicholas J Maness, Andrew J McMichael, Louis J Picker, David H O'Connor, Scott G Hansen, Jonah B Sacha
MHC-E is a highly conserved nonclassical MHC class Ib molecule that predominantly binds and presents MHC class Ia leader sequence-derived peptides for NK cell regulation. However, MHC-E also binds pathogen-derived peptide Ags for presentation to CD8(+) T cells. Given this role in adaptive immunity and its highly monomorphic nature in the human population, HLA-E is an attractive target for novel vaccine and immunotherapeutic modalities. Development of HLA-E-targeted therapies will require a physiologically relevant animal model that recapitulates HLA-E-restricted T cell biology...
November 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29150447/the-prototypical-proton-coupled-oligopeptide-transporter-ydgr-from-escherichia-coli-facilitates-chloramphenicol-uptake-into-bacterial-cells
#3
Bala K Prabhala, Nanda G Aduri, Neha Sharma, Aqsa Shaheen, Arpan Sharma, Mazhar Iqbal, Paul R Hansen, Christoffer Brasen, Michael Gajhede, Moazur Rahman, Osman Mirza
Chloramphenicol (Cam) is a broad-spectrum antibiotic used to combat bacterial infections in humans and animals. Cam export from bacterial cells is one of the mechanisms by which pathogens resist Cam's antibacterial effects, and several different proteins are known to facilitate this process. However, to date no report exists on any specific transport protein that facilitates Cam uptake. The proton-coupled oligopeptide transporter (POT) YdgR from Escherichia coli is a prototypical member of the POT family, functioning in proton-coupled uptake of di- and tripeptides...
November 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29150026/regulatory-t-cells-friends-or-foe-in-human-mycobacterium-leprae-infection
#4
Ana T Chaves, Atvaldo F Ribeiro-Junior, Sandra Lyon, Nayara I Medeiros, Fábio Cassirer-Costa, Karina S Paula, Edilamar S Alecrim, Cristiane A S Menezes, Rodrigo Correa-Oliveira, Manoel O C Rocha, Juliana A S Gomes
Regulatory T cells (Tregs) are known to control immune responses by suppressing the antigen-presenting and effector T cells. Some mechanisms adopted by Tregs in combating Mycobacterium infections have been proposed. Nevertheless, in M. leprae infection, also known as leprosy or Hansen's disease, the role of Tregs has not been completely elucidated. Using multicolor flow cytometry, we evaluated the expression of different cell surface and intracellular molecules present in Tregs from peripheral blood samples of leprosy patients...
November 13, 2017: Immunobiology
https://www.readbyqxmd.com/read/29148520/an-in-vitro-prototype-of-a-porcine-biomimetic-testis-like-cell-culture-system-a-novel-tool-for-the-study-of-reassembled-sertoli-and-leydig-cells
#5
Iva Arato, Giovanni Luca, Francesca Mancuso, Catia Bellucci, Cinzia Lilli, Mario Calvitti, Barbara C Hansen, Domenico Milardi, Giuseppe Grande, Riccardo Calafiore
At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis is regulated by endocrine, paracrine, and juxtacrine factors (testicular cross-talk), mainly orchestrated by gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that play a pivotal role by stimulating Leydig and Sertoli cells, respectively. The aim of our study was to set up an in vitro prepubertal porcine bioengineered construct as a new model for experimental studies on reassembled Sertoli and Leydig cells...
November 10, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29147743/low-implant-migration-of-the-sigma-%C3%A2-medial-unicompartmental-knee-arthroplasty
#6
Daan Koppens, Maiken Stilling, Stig Munk, Jesper Dalsgaard, Søren Rytter, Ole Gade Sørensen, Torben Bæk Hansen
PURPOSE: The purpose of this study was to evaluate implant migration of the fixed-bearing Sigma(®) medial unicompartmental knee arthroplasty (UKA). UKA is a regularly used treatment for patients with medial osteoarthritis (OA) of the knee. UKA has a higher revision rate than total knee arthroplasty. Implant migration can be used as a predictor of implant loosening. METHODS: A prospective radiostereometric cohort study was performed. Forty-five patients with medial OA of the knee were included and received a cemented Sigma(®) UKA...
November 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29146870/structure-of-the-yeast-spliceosomal-postcatalytic-p-complex
#7
Shiheng Liu, Xueni Li, Lingdi Zhang, Jiansen Jiang, Ryan C Hill, Yanxiang Cui, Kirk C Hansen, Z Hong Zhou, Rui Zhao
The spliceosome undergoes dramatic changes in a splicing cycle. Structures of B, B(act), C, C*, and ILS complexes revealed mechanisms of 5' splice site (ss) recognition, branching, and intron release, but lacked information on 3' ss recognition, exon ligation and release. Here, we report a cryoEM structure of the postcatalytic P complex at 3.3Å resolution, revealing that 3' ss is mainly recognized through non-Watson-Crick basepairing with the 5' ss and branch point. Furthermore, an unidentified protein becomes stably associated with the P complex, securing the 3' exon and potentially regulating Prp22 activity...
November 16, 2017: Science
https://www.readbyqxmd.com/read/29146700/phenotypic-spectrum-of-children-with-nephronophthisis-and-related-ciliopathies
#8
Jens König, Birgitta Kranz, Sabine König, Karl Peter Schlingmann, Andrea Titieni, Burkhard Tönshoff, Sandra Habbig, Lars Pape, Karsten Häffner, Matthias Hansen, Anja Büscher, Martin Bald, Heiko Billing, Raphael Schild, Ulrike Walden, Tobias Hampel, Hagen Staude, Magdalena Riedl, Norbert Gretz, Martin Lablans, Carsten Bergmann, Friedhelm Hildebrandt, Heymut Omran, Martin Konrad
BACKGROUND AND OBJECTIVES: Genetic heterogeneity and phenotypic variability are major challenges in familial nephronophthisis and related ciliopathies. To date, mutations in 20 different genes (NPHP1 to -20) have been identified causing either isolated kidney disease or complex multiorgan disorders. In this study, we provide a comprehensive and detailed characterization of 152 children with a special focus on extrarenal organ involvement and the long-term development of ESRD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We established an online-based registry (www...
November 16, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29146556/shedding-light-on-the-role-of-camp-in-mammalian-sperm-physiology
#9
REVIEW
Melanie Balbach, Vera Beckert, Jan N Hansen, Dagmar Wachten
Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the second messenger cAMP (cyclic adenosine monophosphate). In recent years, it has become clear that signal transduction in the sperm is not a continuum, but rather organized in subcellular domains, e.g. the sperm head and the sperm flagellum, with the latter being further separated into the midpiece, principal piece,and endpiece. To understand the underlying signaling pathways controlling sperm function in more detail, experimental approaches are needed that allow to study sperm signaling with spatial and temporal precision...
November 13, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29146191/automatic-delineation-of-brain-regions-on-mri-and-pet-images-from-the-pig
#10
Jonas Villadsen, Hanne D Hansen, Louise M Jørgensen, Sune H Keller, Flemming L Andersen, Ida N Petersen, Gitte M Knudsen, Claus Svarer
BACKGROUND: The increasing use of the pig as a research model in neuroimaging requires standardized processing tools. For example, extraction of regional dynamic time series from brain PET images requires parcellation procedures that benefit from being automated. COMPARISON WITH EXISTING METHODS: Manual inter-modality spatial normalization to a MRI atlas is operator-dependent, time-consuming, and can be inaccurate with lack of cortical radiotracer binding or skull uptake...
November 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29145831/copd-online-rehabilitation-versus-conventional-copd-rehabilitation-rationale-and-design-for-a-multicenter-randomized-controlled-trial-study-protocol-core-trial
#11
Henrik Hansen, Theresa Bieler, Nina Beyer, Nina Godtfredsen, Thomas Kallemose, Anne Frølich
BACKGROUND: Rehabilitation of patients with chronic obstructive pulmonary disease (COPD) is a key treatment in COPD. However, despite the existing evidence and a strong recommendation from lung associations worldwide, 50% of patients with COPD decline to participate in COPD rehabilitation program and 30-50% drop-out before completion. The main reasons are severe symptoms, inflexible accessibility and necessity for transportation. Currently there are no well-established and evident rehabilitation alternatives...
November 16, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29145199/high-fracture-rates-in-young-patients-with-phenylketonuria
#12
Karen E Hansen, Neil Binkley, Denise M Ney
No abstract text is available yet for this article.
November 16, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29144217/mechanisms-of-naturally-acquired-immunity-to-p-falciparum-and-approaches-to-identify-merozoite-antigen-targets
#13
Julie Healer, Chris Y Chiu, Diana S Hansen
Malaria is one the most serious infectious diseases with over 200 million clinical cases annually. Most cases of the severe disease are caused by Plasmodium falciparum. The blood stage of Plasmodium parasite is entirely responsible for malaria-associated pathology. The population most susceptible to severe malaria are children under the age of 5, with low levels of immunity. It is only after many years of repeated exposure that individuals living in endemic areas develop clinical immunity. This form of protection prevents clinical episodes by substantially reducing parasite burden...
November 16, 2017: Parasitology
https://www.readbyqxmd.com/read/29144039/chronic-plaque-on-the-great-toe-of-a-10-year-old-boy
#14
Trevor Hansen, Jessica Smith, Tracy Funk
No abstract text is available yet for this article.
November 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29143324/bioelectrical-impedance-as-a-technique-for-estimating-postmortem-interval
#15
Eriek S Hansen, Christiane Baigent, Sophia I Reck, Melissa Connor
Estimation of postmortem interval (PMI) is a critical component of death investigation. A cadaver can be hypothesized to be a resistor-capacitor (RC) circuit the impedance (Z) of which changes in a quantifiable manner as the cadaver decomposes. This hypothesis was tested using bioelectrical impedance analysis (BIA) equipment to apply a current with a fixed amplitude at a single frequency to four cadavers over time and measuring two components of Z, resistance (R) and reactance (Xc ). Quadratic regression analysis between Z and accumulated degree days (ADD) showed a statistically significant parabolic relationship...
November 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29143140/impact-of-conventional-medical-therapy-on-bone-mineral-density-and-bone-turnover-in-adult-patients-with-x-linked-hypophosphatemia-a-6-year-prospective-cohort-study
#16
Vikram Vinod Shanbhogue, Stinus Hansen, Niklas Rye Jørgensen, Signe Sparre Beck-Nielsen
X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospective study was to determine the impact of conventional medical treatment on areal bone mineral density (aBMD), bone turnover markers (BTMs) and measures of calcium homeostasis in 27 adult patients with XLH, 11 of whom received medical treatment...
November 15, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29142966/oral-magnesium-supplementation-in-chronic-kidney-disease-stages-3-and-4-efficacy-safety-and-effect-on-serum-calcification-propensity-a%C3%A2-prospective-randomized-double-blinded-placebo-controlled-clinical-trial
#17
Iain Bressendorff, Ditte Hansen, Morten Schou, Burton Silver, Andreas Pasch, Pierre Bouchelouche, Lise Pedersen, Lars Melholt Rasmussen, Lisbet Brandi
Introduction: Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. Recent evidence suggests that increases in both serum and intracellular magnesium (Mg) can slow or even prevent the development of vascular calcification seen in CKD. Serum calcification propensity (T50) is a novel functional test, which is associated with all-cause mortality in CKD and measures the ability of serum to delay the formation of crystalline nanoparticles. Theoretically, increasing serum Mg should improve T50 and thereby reduce the propensity towards ectopic calcification...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142533/corrigendum-rna-seq-comparison-of-larval-and-adult-malpighian-tubules-of-the-yellow-fever-mosquito-aedes-aegypti-reveals-life-stage-specific-changes-in-renal-function
#18
Yiyi Li, Peter M Piermarini, Carlos J Esquivel, David P Price, Hannah E Drumm, Faye D Schilkey, Immo A Hansen
[This corrects the article on p. 283 in vol. 8, PMID: 28536536.].
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29142243/genetic-risk-scores-for-body-fat-distribution-attenuate-weight-loss-in-women-during-dietary-intervention
#19
M Svendstrup, K H Allin, T I A Sørensen, T H Hansen, N Grarup, T Hansen, H Vestergaard
BACKGROUND AND AIM: The well-established link between body fat distribution and metabolic health has been suggested to act through an impact on the remodeling capacity of the adipose tissue. Remodeling of the adipose tissue has been shown to affect body fat distribution and might affect the ability to lose weight. We aimed to study the effect of weighted genetic risk scores (GRSs) on weight loss based on single-nucleotide polymorphisms (SNPs) associated with waist-hip-ratio adjusted for body mass index (WHRadjBMI)...
November 16, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29141983/are-parents-who-feel-the-need-to-watch-over-their-children-s-care-better-patient-safety-partners
#20
Elizabeth D Cox, Kristofer Hansen, Victoria P Rajamanickam, Roger L Brown, Paul J Rathouz, Pascale Carayon, Lori L DuBenske, Linda A Buel, Michelle M Kelly
OBJECTIVES: Many parents report needing to watch over their child's hospital care to prevent mistakes. In this study, we assessed whether needing to watch over care predicts parent performance of recommended safety behaviors to reduce medication errors and health care-associated infections. METHODS: At admission, we surveyed 170 parents about their need to watch over care, demographics, and hospitalization factors. At discharge, parents were surveyed about medication awareness and hand hygiene behaviors...
November 15, 2017: Hospital Pediatrics
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