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https://www.readbyqxmd.com/read/29352092/incident-heart-failure-in-patients-with-rheumatoid-arthritis-a-nationwide-cohort-study
#1
Usman Khalid, Alexander Egeberg, Ole Ahlehoff, Deirdre Lane, Gunnar H Gislason, Gregory Y H Lip, Peter R Hansen
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with a wide range of comorbidities, including cardiovascular disease, but its association with heart failure (HF) is not fully clear. We investigated the risk of incident HF in a nationwide cohort of patients with RA. METHODS AND RESULTS: The study comprised the entire Danish population aged ≥18 years followed from January 1, 2008 until first hospitalization for HF, emigration, December 31, 2012, or death...
January 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29351743/phosphate-signaling-through-alternate-conformations-of-the-pstscab-phosphate-transporter
#2
Ramesh K Vuppada, Colby R Hansen, Kirsta A P Strickland, Keilen M Kelly, William R McCleary
BACKGROUND: Phosphate is an essential compound for life. Escherichia coli employs a signal transduction pathway that controls the expression of genes that are required for the high-affinity acquisition of phosphate and the utilization of alternate sources of phosphorous. These genes are only expressed when environmental phosphate is limiting. The seven genes for this signaling pathway encode the two-component regulatory proteins PhoB and PhoR, as well as the high-affinity phosphate transporter PstSCAB and an auxiliary protein called PhoU...
January 19, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29351429/removal-of-interscapular-brown-adipose-tissue-increases-aortic-stiffness-despite-normal-systemic-glucose-metabolism-in-mice
#3
Zachary Ian Grunewald, Nathan C Winn, Michelle L Gastecki, Makenzie L Woodford, James R Ball, Sarah A Hansen, Harold S Sacks, Victoria J Vieira-Potter, Jaume Padilla
Brown adipose tissue (BAT) is considered protective against obesity and related cardiometabolic dysfunction. Indeed, activation of BAT improves glucose homeostasis and attenuates cardiovascular disease development. However, whether a reduction in BAT mass perturbs metabolic function and increases risk for cardiovascular disease remains largely unknown. To address this question, C57BL/6J male mice underwent sham or surgical bilateral excision of interscapular BAT (iBATx) and were fed a normal chow or Western diet (WD) for 18 weeks, creating four groups (n=10/group)...
December 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351286/socio-economic-determinants-of-physical-activity-across-the-life-course-a-determinants-of-diet-and-physical-activity-dedipac-umbrella-literature-review
#4
Grainne O'Donoghue, Aileen Kennedy, Anna Puggina, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Angela Carlin, Donatella Ciarapica, Marco Colotto, Giancarlo Condello, Tara Coppinger, Cristina Cortis, Sara D'Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Fiona Ling, Agnes Luzak, Giorgio Napolitano, Julie-Anne Nazare, Camille Perchoux, Caterina Pesce, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz, Chantal Simon, Rhoda Sohun, Astrid Steinbrecher, Wolfgang Schlicht, Ciaran MacDonncha, Laura Capranica, Stefania Boccia
BACKGROUND: To date, the scientific literature on socioeconomic correlates and determinants of physical activity behaviours has been dispersed throughout a number of systematic reviews, often focusing on one factor (e.g. education or parental income) in one specific age group (e.g. pre-school children or adults). The aim of this umbrella review is to provide a comprehensive and systematic overview of the scientific literature from previously conducted research by summarising and synthesising the importance and strength of the evidence related to socioeconomic correlates and determinants of PA behaviours across the life course...
2018: PloS One
https://www.readbyqxmd.com/read/29350434/the-cystine-glutamate-exchanger-xct-slc7a11-is-expressed-in-significant-concentrations-in-a-subpopulation-of-astrocytes-in-the-mouse-brain
#5
Sigrid Ottestad-Hansen, Qiu Xiang Hu, Virgine Veronique Follin-Arbelet, Eduard Bentea, Hideyo Sato, Ann Massie, Yun Zhou, Niels Christian Danbolt
The cystine-glutamate exchanger (xCT) promotes glutathione synthesis by catalyzing cystine uptake and glutamate release. The released glutamate may modulate normal neural signaling and contribute to excitotoxicity in pathological situations. Uncertainty, however, remains as neither the expression levels nor the distribution of xCT have been unambiguously determined. In fact, xCT has been reported in astrocytes, neurons, oligodendrocytes and microglia, but most of the information derives from cell cultures. Here, we show by immunohistochemistry and by Western blotting that xCT is widely expressed in the central nervous system of both sexes...
January 19, 2018: Glia
https://www.readbyqxmd.com/read/29349235/social-pathways-to-health-on-the-mediating-role-of-the-social-network-in-the-relation-between-socio-economic-position-and-health
#6
Marja Aartsen, Marijke Veenstra, Thomas Hansen
Good health is one of the key qualities of life, but opportunities to be and remain healthy are unequally distributed across socio-economic groups. The beneficial health effects of the social network are well known. However, research on the social network as potential mediator in the pathway from socio-economic position (SEP) to health is scarce, while there are good reasons to expect a socio-economical patterning of networks. We aim to contribute to our understanding of socio-economic inequalities in health by examining the mediating role of structural and functional characteristics of the social network in the SEP-health relationship...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29348807/discovery-of-spiro-oxazolidinediones-as-selective-orally-bioavailable-inhibitors-of-p300-cbp-histone-acetyltransferases
#7
Michael R Michaelides, Arthur Kluge, Michael Patane, John H Van Drie, Ce Wang, T Matthew Hansen, Roberto M Risi, Robert Mantei, Carmen Hertel, Kannan Karukurichi, Alexandre Nesterov, David McElligott, Peter de Vries, J William Langston, Philip A Cole, Ronen Marmorstein, Hong Liu, Loren Lasko, Kenneth D Bromberg, Albert Lai, Edward A Kesicki
p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (HAT) domain inhibitor has been identified through virtual ligand screening and subsequent optimization of a unique hydantoin screening hit. Conformational restraint in the form of a spirocyclization followed by substitution with a urea led to a significant improvement in potency...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29348645/a-global-perspective-on-the-trophic-geography-of-sharks
#8
Christopher S Bird, Ana Veríssimo, Sarah Magozzi, Kátya G Abrantes, Alex Aguilar, Hassan Al-Reasi, Adam Barnett, Dana M Bethea, Gérard Biais, Asuncion Borrell, Marc Bouchoucha, Mariah Boyle, Edward J Brooks, Juerg Brunnschweiler, Paco Bustamante, Aaron Carlisle, Diana Catarino, Stéphane Caut, Yves Cherel, Tiphaine Chouvelon, Diana Churchill, Javier Ciancio, Julien Claes, Ana Colaço, Dean L Courtney, Pierre Cresson, Ryan Daly, Leigh de Necker, Tetsuya Endo, Ivone Figueiredo, Ashley J Frisch, Joan Holst Hansen, Michael Heithaus, Nigel E Hussey, Johannes Iitembu, Francis Juanes, Michael J Kinney, Jeremy J Kiszka, Sebastian A Klarian, Dorothée Kopp, Robert Leaf, Yunkai Li, Anne Lorrain, Daniel J Madigan, Aleksandra Maljković, Luis Malpica-Cruz, Philip Matich, Mark G Meekan, Frédéric Ménard, Gui M Menezes, Samantha E M Munroe, Michael C Newman, Yannis P Papastamatiou, Heidi Pethybridge, Jeffrey D Plumlee, Carlos Polo-Silva, Katie Quaeck-Davies, Vincent Raoult, Jonathan Reum, Yassir Eden Torres-Rojas, David S Shiffman, Oliver N Shipley, Conrad W Speed, Michelle D Staudinger, Amy K Teffer, Alexander Tilley, Maria Valls, Jeremy J Vaudo, Tak-Cheung Wai, R J David Wells, Alex S J Wyatt, Andrew Yool, Clive N Trueman
Sharks are a diverse group of mobile predators that forage across varied spatial scales and have the potential to influence food web dynamics. The ecological consequences of recent declines in shark biomass may extend across broader geographic ranges if shark taxa display common behavioural traits. By tracking the original site of photosynthetic fixation of carbon atoms that were ultimately assimilated into muscle tissues of 5,394 sharks from 114 species, we identify globally consistent biogeographic traits in trophic interactions between sharks found in different habitats...
January 18, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29348612/gwas-in-childhood-acute-lymphoblastic-leukemia-reveals-novel-genetic-associations-at-chromosomes-17q12-and-8q24-21
#9
Joseph L Wiemels, Kyle M Walsh, Adam J de Smith, Catherine Metayer, Semira Gonseth, Helen M Hansen, Stephen S Francis, Juhi Ojha, Ivan Smirnov, Lisa Barcellos, Xiaorong Xiao, Libby Morimoto, Roberta McKean-Cowdin, Rong Wang, Herbert Yu, Josephine Hoh, Andrew T DeWan, Xiaomei Ma
Childhood acute lymphoblastic leukemia (ALL) (age 0-14 years) is 20% more common in Latino Americans than non-Latino whites. We conduct a genome-wide association study in a large sample of 3263 Californian children with ALL (including 1949 of Latino heritage) and 3506 controls matched on month and year of birth, sex, and ethnicity, and an additional 12,471 controls from the Kaiser Resource for Genetic Epidemiology Research on Aging Cohort. Replication of the strongest genetic associations is performed in two independent datasets from the Children's Oncology Group and the California Childhood Leukemia Study...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29348120/apoc3-loss-of-function-mutations-remnant-cholesterol-low-density-lipoprotein-cholesterol-and-cardiovascular-risk-mediation-and-meta-analyses-of-137-895-individuals
#10
Anders B Wulff, Børge G Nordestgaard, Anne Tybjærg-Hansen
OBJECTIVE: Loss-of-function mutations in APOC3 associate with low remnant cholesterol levels and low risk of ischemic vascular disease (IVD). Because some studies show an additional association with low levels of low-density lipoprotein cholesterol (LDL-C), low LDL-C may explain the low risk of IVD in APOC3 loss-of-function heterozygotes. We tested to what extent the low risk of IVD in APOC3 loss-of-function heterozygotes is mediated by low plasma remnant cholesterol and LDL-C. APPROACH AND RESULTS: In APOC3 loss-of-function heterozygotes versus noncarriers, we first determined remnant cholesterol and LDL-C levels in meta-analyses of 137 895 individuals...
January 18, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29347888/patient-baseline-interpersonal-problems-as-moderators-of-outcome-in-two-psychotherapies-for-bulimia-nervosa
#11
Juan Martin Gomez Penedo, Michael J Constantino, Alice E Coyne, Samantha L Bernecker, Lotte Smith-Hansen
OBJECTIVE: We tested an aptitude by treatment interaction; namely, whether patients' baseline interpersonal problems moderated the comparative efficacy of cognitive-behavioral therapy (CBT) vs. interpersonal psychotherapy (IPT) for bulimia nervosa (BN). METHOD: Data derived from a randomized-controlled trial. Patients reported on their interpersonal problems at baseline; purge frequency at baseline, midtreatment, and posttreatment; and global eating disorder severity at baseline and posttreatment...
January 19, 2018: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/29347468/hypernetted-chain-like-closure-of-ornstein-zernike-equation-in-multibody-dissipative-particle-dynamics
#12
Chao-Jie Mo, Li-Zi Qin, Li-Jun Yang
We have derived a hypernetted-chain-like (HNC-like) approximate closure of the Ornstein-Zernike equation for multibody dissipative particle dynamics (MDPD) system in which the classic closures are not directly practicable. We first point out that the Percus's method is applicable to MDPD system in which particles interact with a density-dependent potential. And then an HNC-like closure is derived using Percus's idea and the saddle-point approximation of particle free energy. This HNC-like closure is compared with results of previous researchers, and in many cases, it demonstrates better agreement with computer simulation results...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346778/diverse-brain-myeloid-expression-profiles-reveal-distinct-microglial-activation-states-and-aspects-of-alzheimer-s-disease-not-evident-in-mouse-models
#13
Brad A Friedman, Karpagam Srinivasan, Gai Ayalon, William J Meilandt, Han Lin, Melanie A Huntley, Yi Cao, Seung-Hye Lee, Patrick C G Haddick, Hai Ngu, Zora Modrusan, Jessica L Larson, Joshua S Kaminker, Marcel P van der Brug, David V Hansen
Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We derived co-regulated gene modules from transcriptional profiles of CNS myeloid cells of diverse mouse models, including new tauopathy model datasets. Using these modules to interpret single-cell data from an Alzheimer's disease (AD) model, we identified microglial subsets-distinct from previously reported "disease-associated microglia"-expressing interferon-related or proliferation modules...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346300/trapezium-bone-density-a-comparison-of-measurements-by-dxa-and-ct
#14
Sebastian Breddam Mosegaard, Kamille Breddam Mosegaard, Nadia Bouteldja, Torben Bæk Hansen, Maiken Stilling
Bone density may influence the primary fixation of cementless implants, and poor bone density may increase the risk of implant failure. Before deciding on using total joint replacement as treatment in osteoarthritis of the trapeziometacarpal joint, it is valuable to determine the trapezium bone density. The aim of this study was to: (1) determine the correlation between measurements of bone mineral density of the trapezium obtained by dual-energy X-ray absorptiometry (DXA) scans by a circumference method and a new inner-ellipse method; and (2) to compare those to measurements of bone density obtained by computerized tomography (CT)-scans in Hounsfield units (HU)...
January 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29343243/retrospectively-assessed-psychosocial-working-conditions-as-predictors-of-prospectively-assessed-sickness-absence-and-disability-pension-among-older-workers
#15
Emil Sundstrup, Åse Marie Hansen, Erik Lykke Mortensen, Otto Melchior Poulsen, Thomas Clausen, Reiner Rugulies, Anne Møller, Lars L Andersen
BACKGROUND: The aim was to explore the association between retrospectively assessed psychosocial working conditions during working life and prospectively assessed risk of sickness absence and disability pension among older workers. METHODS: The prospective risk of register-based long-term sickness absence (LTSA) and disability pension was estimated from exposure to 12 different psychosocial work characteristics during working life among 5076 older workers from the CAMB cohort (Copenhagen Aging and Midlife Biobank)...
January 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29343209/mild-blast-injury-produces-acute-changes-in-basal-intracellular-calcium-levels-and-activity-patterns-in-mouse-hippocampal-neurons
#16
Kyle R Hansen, Gloria J DeWalt, Ali I Mohammed, Hua-An Tseng, Moona E Abdulkerim, Seth Bensussen, Venkatesh Saligrama, Bobak Nazer, William D Eldred, Xue Han
Mild traumatic brain injury (mTBI) represents a serious public health concern. While much is understood about long term changes in cell signaling and anatomical pathologies associated with mTBI, little is known about acute changes in neuronal function. Using large scale Ca2+ imaging in vivo, we characterized the intracellular Ca2+ dynamics in thousands of individual hippocampal neurons using a repetitive mild blast injury model where blasts were directed onto the cranium of unanesthetized mice on two consecutive days...
January 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29341414/post-translational-incorporation-of-3-4-dihydroxyphenylalanine-into-the-c-terminus-of-%C3%AE-tubulin-in-living-cells
#17
Yanela M Dentesano, Yanina Ditamo, Cristian Hansen, Carlos A Arce, C Gastón Bisig
The C-terminal tyrosine (Tyr) of the α-tubulin chain is subjected to post-translational removal and re-addition in a process termed the "detyrosination/tyrosination cycle". We showed in previous studies using soluble rat brain extracts that L-3,4-dihydroxyphenylalanine (L-Dopa) is incorporated into the same site as Tyr. We now demonstrate that L-Dopa incorporation into tubulin also occurs in living cells. We detected such incorporation by determining the "tyrosination state" of tubulin before and after incubation of cells in the presence of L-Dopa...
January 17, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29338313/rapport-building-and-instructional-fading-prior-to-discrete-trial-instruction-moving-from-child-led-play-to-intensive-teaching
#18
M Alice Shillingsburg, Bethany Hansen, Melinda Wright
Discrete trial instruction (DTI) is effective for teaching skills to children with autism spectrum disorder (ASD). Although effective, instructional settings can become aversive resulting in avoidant and escape-related behaviors. Given the significant social impairments associated with ASD, interventions that promote social approach and reduce avoidance are warranted. Rapport building or "pairing" the therapist and teaching setting with highly preferred activities prior to instruction can reduce problematic behaviors during subsequent instruction...
January 1, 2018: Behavior Modification
https://www.readbyqxmd.com/read/29338206/application-of-ptr-ms-and-33s-isotope-labelling-for-monitoring-sulfur-processes-in-livestock-waste
#19
Frederik Rask Dalby, Michael Jørgen Hansen, Anders Feilberg
Reduced sulfur compounds emitted from livestock production cause odor nuisance for local residents. The microbial processes responsible for this are not well described in swine manure and a method for monitoring the biological processes is necessary to develop strategic abatement technologies. In this study, Proton-Transfer-Reaction Mass Spectrometry and isotope labelled sulfate was combined and applied to elucidate the sulfur processes in swine manure with high time resolution. We successfully monitored reduction of isotope 33S labelled sulfate into corresponding 33S hydrogen sulfide and that some of the 33S hydrogen sulfide was further methylated into 33S methanethiol...
January 17, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29338123/choroidal-thickness-and-myopia-in-relation-to-physical-activity-the-champs-eye-study
#20
Kristian Lundberg, Anders Højslet Vestergaard, Nina Jacobsen, Anne Suhr Thykjaer, Rasmus Søgaard Hansen, Ernst Goldschmidt, Tunde Peto, Ulrich Halekoh, Niels Wedderkopp, Jakob Grauslund
PURPOSE: To describe the relationship between choroidal thickness (CT) and myopia in relation to physical activity (PA) in a population-based child cohort. METHODS: In a prospective study of 307 children from the CHAMPS Study Denmark, we used objective data from GT3X accelerometer worn at four periods between 2009 and 2015 to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut-off points were defined at four intensity levels...
January 16, 2018: Acta Ophthalmologica
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