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https://www.readbyqxmd.com/read/28110361/the-impact-of-routine-whole-spine-mri-screening-in-the-evaluation-of-spinal-degenerative-diseases
#1
Rishi Mugesh Kanna, Younis Kamal, Anupama Mahesh, Prakash Venugopal, Ajoy Prasad Shetty, S Rajasekaran
PURPOSE: Magnetic resonance imaging (MRI) of the spine is a sensitive investigation, which not only provides detailed images of the spinal column but also adjacent spinal regions and para-vertebral organ systems. Such incidental findings (IF) can be asymptomatic but significant. The efficacy of whole spine T2 sagittal screening in providing additional information has been demonstrated in several spinal diseases but its routine use in patients with spinal degenerative diseases has not been studied...
January 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28107236/surgical-technique-for-decompression-of-severe-thoracic-myelopathy-due-to-tuberous-ossification-of-ligamentum-flavum
#2
Ting Wang, Chuqiang Yin, Dechun Wang, Shuzhong Li, Xiaoliang Chen
STUDY DESIGN: Retrospective review. OBJECTIVE: To describe a safe surgical procedure, en bloc resection of the posterior wall of the thoracic canal, for the decompression of severe thoracic myelopathy caused by tuberous ossification of the ligamentum flavum (OLF). SUMMARY OF BACKGROUND DATA: OLF has been widely recognized as a cause of thoracic myelopathy in East Asia. Surgical decompression of thoracic myelopathy caused by OLF is technically demanding...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28104936/myelopathy-in-adult-aortic-coarctation-causes-and-caveats-of-an-atypical-presentation
#3
Chandan Mourya, Ashish Verma, Anand Bansal, Ram C Shukla, Arvind Srivastava
A 57-year-old female presenting with acute-onset paraplegia was referred for magnetic resonance imaging (MRI) of cervico-dorsal spine. On MRI, multiple tortuous dilated vessels were noted in the epidural space with long segment cord compression and imaging features of compressive myelopathy. Associated small acute cervico-dorsal epidural hematoma was also noted in the same region. Computed tomography (CT) angiography was performed subsequently which revealed post-ductal coarctation of aorta with multiple arterial collaterals in the chest wall and spinal canal...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28104281/-results-to-4-year-follow-up-of-the-treatment-of-the-cervical-stenosis-by-corpectomy-titanium-mesh-cage-and-anterior-plate-fixation
#4
Alejandro Antonio Reyes Sánchez, Luis Alberto Gameros Castañeda, Claudia Obil Chavarría, Armando Alpizar Aguirre, Barón Zárate Kalfópulos, Luis Miguel Rosales-Olivares
BACKGROUND: Cervical spondylotic myelopathy is caused by cervical stenosis. Several techniques have been described for the treatment of multilevel disease, such as the anterior corpectomy with titanium mesh cage and anterior cervical plate placement, which has the advantage of performing a wider decompression and using the same bone as graft. However, it has caused controversy since the collapse of the mesh cage continues being a major limitation of this procedure. MATERIAL AND METHOD: A prospective 4-year follow-up study was conducted in 7 patients diagnosed with cervical stenosis, who were treated surgically by one level corpectomy with titanium mesh cage and anterior cervical plate placement, evaluating them by radiographs and clinical scales...
January 16, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28104259/utility-of-extension-views-in-spondylotic-myelopathy-mimicking-transverse-myelitis
#5
Brittani L Conway, Michelle J Clarke, Timothy J Kaufmann, Eoin P Flanagan
Cervical spondylotic myelopathy is a common cause of myelopathy and may mimic transverse myelitis. We report a 55 year-old lady with subacute myelopathy initially treated with glatiramer acetate for suspected clinically isolated syndrome. MRI head and spine revealed a single short cervical cord T2-hyperintense lesion with enhancement just below a region of moderate stenosis. Cerebrospinal fluid revealed elevated oligoclonal bands. Repeat MRI 7 months later showed persistent enhancement. Dynamic MRI revealed cord compression during extension...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28102813/intramedullary-amputation-neuroma-a-case-report-and-review-of-the-literature
#6
Laura Stone McGuire, Mandana Behbahini, Sumit Das, David Loeffler, Peter Burger, Herbert Engelhard, Tibor Valyi-Nagy, Ankit Mehta
BACKGROUND AND IMPORTANCE: Amputation neuromas consist of non-neoplastic collections of myelinated axons and Schwann cells and typically arise in injured peripheral nerves. Rarely, however, neuromas occur within the spinal cord. Intramedullary amputation neuromas have been described both with and without a history of trauma within the peripheral nervous system. We report a rare case of an isolated intramedullary spinal cord amputation neuroma. CLINICAL PRESENTATION: This 43-year-old man presented with progressive and severe gait deterioration for ~ 7 years...
January 19, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28102449/development-of-a-new-assessment-tool-for-cervical-myelopathy-using-hand-tracking-sensor-part-2-normative-values
#7
M Abdulhadi Alagha, Mahmoud A Alagha, Eleanor Dunstan, Olaf Sperwer, Kate A Timmins, Bronek M Boszczyk
PURPOSE: To set a baseline measurement of the number of hand flexion-extension cycles and analyse the degree of motion in young healthy individuals, measured by leap motion controller (LMC), besides describing gender and dominant hand differences. METHODS: Fifty healthy participants were asked to fully grip-and-release their dominant hand as rapidly as possible for a maximum of 3 min or until subjects fatigued, while wearing a non-metal wrist splint. Participants also performed a 15-s grip-and-release test...
January 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28102448/development-of-a-new-assessment-tool-for-cervical-myelopathy-using-hand-tracking-sensor-part-1-validity-and-reliability
#8
M Abdulhadi Alagha, Mahmoud A Alagha, Eleanor Dunstan, Olaf Sperwer, Kate A Timmins, Bronek M Boszczyk
PURPOSE: To assess the reliability and validity of a hand motion sensor, Leap Motion Controller (LMC), in the 15-s hand grip-and-release test, as compared against human inspection of an external digital camera recording. METHODS: Fifty healthy participants were asked to fully grip-and-release their dominant hand as rapidly as possible for two trials with a 10-min rest in-between, while wearing a non-metal wrist splint. Each test lasted for 15 s, and a digital camera was used to film the anterolateral side of the hand on the first test...
January 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28101786/evaluation-of-t-regulatory-lymphocytes-transcription-factors-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#9
Sanaz Ahmadi Ghezeldasht, Hamed Sadeghian, Mahmoud Reza Azarpazhooh, Seyyed Ali Akbar Shamsian, Houshang Rafatpanah, Mahmood Mahmoodi, Seyyed Abdolrahim Rezaee
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an aggressive neurological disease. The CD4(+)CD25(+) T cell population plays pivotal roles in the maintenance of immunological tolerance and prevention of such autoimmune diseases. In the current study, proviral load (PVL), factor forkhead box p3 (Foxp3), and glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) gene expression and regulatory T cells (Tregs) counts of 21 HAM/TSP patients and 16 HTLV-1 healthy carriers (ACs) were measured using real-time PCR, TaqMan method, and flow cytometry...
January 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28099187/a-comparative-study-of-anterior-decompression-with-fusion-and-posterior-decompression-with-laminoplasty-for-the-treatment-of-cervical-spondylotic-myelopathy-patients-with-large-anterior-compression-of-the-spinal-cord
#10
Takashi Hirai, Toshitaka Yoshii, Yoshiyasu Arai, Kenichiro Sakai, Ichiro Torigoe, Hidetsugu Maehara, Masaki Tomori, Takashi Taniyama, Hirokazu Sato, Atsushi Okawa
STUDY DESIGN: This is a retrospective observational single-center study. OBJECTIVES: To compare anterior decompression and fusion (ADF) and laminoplasty (LAMP) for the treatment of cervical spondylotic myelopathy (CSM) patients with large anterior compression in terms of clinical and radiologic outcomes. SUMMARY OF BACKGROUND DATA: We have reported that insufficient posterior decompression could be often seen after laminoplasty for CSM patients with preoperative anterior clearance of the spinal cord, defined as an interval <4 mm between the preoperative the modified K-line and anterior structure of the spinal canal at most compressive segment on sagittal T1-weighted magnetic resonance imaging...
January 17, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28095504/cytoplasmic-localization-of-htlv-1-hbz-protein-a-biomarker-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp
#11
Marco Baratella, Greta Forlani, Goutham U Raval, Alessandra Tedeschi, Olivier Gout, Antoine Gessain, Giovanna Tosi, Roberto S Accolla
HTLV-1 is the causative agent of a severe form of adult T cell leukemia/Lymphoma (ATL), and of a chronic progressive neuromyelopathy designated HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Two important HTLV-1-encoded proteins, Tax-1 and HBZ, play crucial roles in the generation and maintenance of the oncogenic process. Less information is instead available on the molecular and cellular mechanisms leading to HAM/TSP. More importantly, no single specific biomarker has been described that unambiguously define the status of HAM/TSP...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28087188/operative-fusion-of-multilevel-cervical-spondylotic-myelopathy-impact-of-patient-demographics
#12
Shearwood McClelland, Bryan J Marascalchi, Peter G Passias, Themistocles S Protopsaltis, Anthony K Frempong-Boadu, Thomas J Errico
Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction in patients older than age 55, with operative management being a widely adopted approach. Previous work has shown that private insurance status, gender and patient race are predictive of the operative approach patients receive (anterior-only, posterior-only, combined anterior-posterior). The Nationwide Inpatient Sample from 2001 to 2010 was used to assess the potential role of multilevel CSM as a contributing factor in determining which operative approach CSM patients receive, as it is rare for an anterior-only approach to be sufficient for CSM patients requiring fusion of four or more involved levels...
January 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28076997/surgical-treatment-of-severe-multilevel-circumferential-compressive-myelopathy-of-the-cervical-spine-is-circumferential-procedure-necessary
#13
Xiao-Kang Liu, Hao Li, Jian-Guang Xu, Er-Zhu Yang, Tie-Sheng Hou, Bing-Fang Zeng, Xiao-Feng Lian
OBJECTIVE: To determine the necessity of circumferential decompression and fusion in patients with severe multilevel cervical spondylotic myelopathy with circumferential cord compression. METHODS: This prospective study involved 51 patients with severe multilevel circumferential cervical myelopathy underwent two-stage circumferential procedure between July 2008 and June 2010. VAS scores, satisfaction surveys and JOA scores and imaging studies were obtained. Twenty-three patients (45...
January 11, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28073734/acute-parasitic-and-other-infectious-myelopathies-in-the-tropics-26-cases-at-the-university-hospital-in-conakry
#14
F A Cisse, W A E Ekué, L Barry, S D Barry, M L Touré, A Cissé
In tropical countries, laboratory-confirmed diagnostic certainty of parasitic and other infectious causes of acute myelopathy is difficult because of a shortage of medical professionals and consulting delays. We performed a retrospective study of 168 patients hospitalized for spinal disorders between 2007 and 2013 and identified 26 diagnosed with acute non-compressive myelopathy of presumed sudden onset. An parasitic or other infectious cause was established for all. A preliminary clinical infection preceding the development of neurologic signs was reported for 22 patients (84...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28073140/-clinical-and-radiological-results-after-anterior-cervical-corpectomy-with-cage-fusion-a-retrospective-comparison-of-peek-vs-titanium-cages
#15
Chris Schulz, Uwe Max Mauer, René Mathieu
Background Anterior cervical corpectomy and fusion (ACCF) has become a standard procedure for patients with spondylotic myelopathy due to multisegmental stenosis of the cervical canal. Beside the fusion technique using autogenous bone grafts, synthetic cages have been increasingly used in recent years. Published information on the clinical and radiological results of different cage materials for ACCF is still limited. The study presented here is the largest series to date reporting clinical and radiological outcomes and complication rates after one- to three-level ACCF using structural polyetheretherketone (PEEK) or titanium cages augmented by anterior plate-screw osteosynthesis...
January 10, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28069688/up-regulation-of-cb2-receptors-in-reactive-astrocytes-in-canine-degenerative-myelopathy-a-disease-model-of-amyotrophic-lateral-sclerosis
#16
María Fernández-Trapero, Francisco Espejo-Porras, Carmen Rodríguez-Cueto, Joan R Coates, Carmen Pérez-Díaz, Eva de Lago, Javier Fernández-Ruiz
Targeting the CB2 receptor afforded neuroprotection in SOD1(G93A) mutant mice, a model of amyotrophic lateral sclerosis (ALS). The neuroprotective effects of CB2 receptors were facilitated by their up-regulation in the spinal cord in SOD1(G93A) mutant mice. Herein, we have investigated whether a similar CB2 receptor up-regulation, as well as parallel changes in other endocannabinoid elements, are evident in the spinal cord of dogs with degenerative myelopathy (DM), caused from mutations in the superoxide dismutase 1 gene (SOD1)...
January 9, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28068277/initial-experience-with-o-arm-navigated-spinal-surgery-report-on-two-cases
#17
Ivo I Kehayov, Christo B Zhelyazkov, Borislav M Kalnev, Atanas N Davarski, Borislav D Kitov, Stefan D Raykov
Image-guided spinal surgery is becoming increasingly popular because it allows surgeons to achieve minimal invasiveness and maximum precision in the performed procedures. We present our initial experience with two cases operated on using O-arm-based spinal navigation at the Clinic of Neurosurgery in St George University Hospital, Plovdiv, Bulgaria. In the first case, we performed removal of extradural spinal tumor of the sixth thoracic vertebra and O-arm-navigated pedicle screw fixation. In the second case, we performed O-arm-navigated corpectomy of the fifth cervical vertebra and anterior spinal reconstruction and fusion with titanium expandable mesh and cervical plate in connection with degenerative narrowing of the cervical spinal canal that lead to clinically manifested myelopathy...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28067563/suspected-cervical-myelopathy-an-unexpected-diagnosis
#18
Besa Ziso, Andrew J Larner, Baba M Aji
No abstract text is available yet for this article.
January 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28065875/comparing-quality-of-life-in-cervical-spondylotic-myelopathy-with-other-chronic-debilitating-diseases-using-the-sf-36-survey
#19
Taemin Oh, Renaud Lafage, Virginie Lafage, Themistocles Protopsaltis, Vincent Challier, Christopher Shaffrey, Han Jo Kim, Paul Arnold, Jens Chapman, Frank Schwab, Eric Massicotte, Tim Yoon, Shay Bess, Michael Fehlings, Justin Smith, Christopher Ames
BACKGROUND: Although cervical spondylotic myelopathy (CSM) can be devastating, its relative impact on general health remains unclear. Patient responses to the SF-36 PCS/MCS were compared between CSM and other diseases to evaluate their respective impacts on quality of life. OBJECTIVE: Compare SF-36 PCS/MCS scores in CSM to population and disease-specific norms. METHODS: Retrospective analysis of a prospective, multi-center AOSpine North American CSM Study database...
January 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28062724/mthfr-c677t-polymorphism-is-associated-with-methotrexate-induced-myelopathy-risk
#20
Kelsey Juster-Switlyk, A Gordon Smith, Tibor Kovacsovics, Deborah Stephens, Martha Glenn, Cheryl Ann Palmer, Edward P Quigley, Noah Kolb
No abstract text is available yet for this article.
January 6, 2017: Neurology
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