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https://www.readbyqxmd.com/read/28648091/mediators-go-together-high-production-of-cxcl9-cxcl10-ifn-%C3%AE-and-tnf-%C3%AE-in-ham-tsp
#1
Heytor Victor Pereira da Costa Neco, Vanessa Gabryelle da Silva Teixeira, Ana Carolina Lemos da Trindade, Paula Machado Ribeiro Magalhães, Virgínia Maria Barros de Lorena, Lúcio Roberto Cançado Castellano, Joelma Rodrigues de Souza, Luydson Richardson Vasconcelos, Patrícia Muniz Mendes Freire de Moura, Clarice Neuenschwander Lins de Morais
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic demyelinating and disabling syndrome caused by HTLV-1. Although the pathogenic mechanisms that lead to HAM/TSP outcome have not been elucidated, genetic and immunological factors may be involved in the myelopathy occurrence. The present study aimed to compare cytokines, chemokines and nitric oxide levels in asymptomatic and HAM/TSP HTLV-1 infected patients. The study group consisted of 21 HAM/TSP and 48 asymptomatic HTLV-1 patients...
June 24, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28647748/single-level-anterior-cervical-corpectomy-and-fusion-using-a-new-3d-printed-anatomy-adaptive-titanium-mesh-cage-for-treatment-of-cervical-spondylotic-myelopathy-and-ossification-of-the-posterior-longitudinal-ligament-a-retrospective-case-series-study
#2
Teng Lu, Chao Liu, Baohui Yang, Jiantao Liu, Feng Zhang, Dong Wang, Haopeng Li, Xijing He
BACKGROUND The aim of this study was to evaluate the clinical and radiological outcomes of the use of a new 3D-printed anatomy-adaptive titanium mesh cage (AA-TMC) for single-level anterior cervical corpectomy and fusion (ACCF) in patients with cervical spondylotic myelopathy (CSM) and ossification of the posterior longitudinal ligament (OPLL). MATERIAL AND METHODS We retrospectively reviewed the records of 15 consecutive patients who underwent ACCF surgeries with AA-TMC implantation. The Japanese Orthopedic Association (JOA) scoring system, a visual analogue scale (VAS), the mean intervertebral height (MIBH) of the surgical segments, and the surgical segmental angle (SSA) were recorded preoperatively, immediately after surgery and at the final follow-up visit...
June 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28645597/spinal-arteriovenous-malformation-associated-with-parkes-weber-syndrome-report-of-two-cases-and-literature-review
#3
Zi-Fu Li, Qiang Li, Yi Xu, Bo Hong, Qing-Hai Huang, Jian-Min Liu
OBJECTIVE: To present two cases of Parkes Weber syndrome (PWS) with spinal arteriovenous malformation(AVM), and discuss the radiological features and clinical treatment with literature review. METHODS: Clinical data on two PWS patients with spinal AVM was acquired in a prospective follow-up investigation. Clinical manifestations, radiographic features, procedural results and follow-up outcome were collected and reviewed together with literature review. RESULTS: The first patient presented with limb weakness and urinary dysfunction and the second with repetitive subarachnoid hemorrhage followed by paraplegia...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28644963/self-report-and-subjective-history-in-the-diagnosis-of-painful-neck-conditions-a-systematic-review-of-diagnostic-accuracy-studies
#4
REVIEW
Adam Mizer, Alexa Bachmann, Jessie Gibson, Megan Burrowbridge Donaldson
Rising healthcare costs and inherent risks with over-utilizing diagnostic imaging require a quality subjective examination to improve effectiveness and time management of physical examinations. This systematic review investigates the diagnostic accuracy of subjective history and self-report items to determine if there is significant alteration in the probability of identifying specific painful neck conditions. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. INCLUSION CRITERIA: 1) Written in the English language 2) Cervical pain with/without referred upper extremity or head pain 3) Subjective history or self-report items 4) Study designs that reported diagnostic statistics or allowed calculation of sensitivities, specificities, diagnostic odds ratios, and likelihood ratios 5) used a reference standard that has a sensitivity or specificity ≥75% or a diagnostic tool that is strongly supported in the literature where this data is not available...
June 8, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28634065/remote-lesions-of-synchronous-sacral-and-cervical-dural-arteriovenous-fistulas-a-case-report
#5
Yasuyuki Kaku, Yuki Ohmori, Takayuki Kawano, Yuki Takeshima, Jun-Ichi Kuratsu
BACKGROUND: Spinal dural arteriovenous fistula (DAVF) is a rare disease and multiple concurrent lesions are extremely rare. Such multiple spinal DAVFs have similar outflow routes at neighboring levels. However, there have been no reported cases of remote lesions of multiple spinal DAVFs. The authors herein report a case of double synchronous cervical and sacral DAVFs. CASE DESCRIPTION: A 56-year-old man with no prior history of disease presented with progressive myelopathy, and spinal magnetic resonance imaging (MRI) showed extensive edema of the spinal cord from the conus to T7...
June 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28632603/which-way-do-we-go-commentary-on-an-article-by-so-kato-md-et-al-comparison-of-anterior-and-posterior-surgery-for-degenerative-cervical-myelopathy-an-mri-based-propensity-score-matched-analysis-using-data-from-the-prospective-multicenter-aospine-csm-north-america
#6
https://www.readbyqxmd.com/read/28632590/comparison-of-anterior-and-posterior-surgery-for-degenerative-cervical-myelopathy-an-mri-based-propensity-score-matched-analysis-using-data-from-the-prospective-multicenter-aospine-csm-north-america-and-international-studies
#7
So Kato, Aria Nouri, Dongjin Wu, Satoshi Nori, Lindsay Tetreault, Michael G Fehlings
BACKGROUND: Surgeons often choose between 2 different approaches (anterior and posterior) for surgical treatment of degenerative cervical myelopathy on the basis of imaging features of spinal cord compression, the number of levels affected, and the spinal alignment. However, there is a lack of consensus on which approach is preferable. The objective of the present study was to use magnetic resonance imaging (MRI)-based propensity-score-matched analysis to compare postoperative outcomes between the anterior and posterior surgical approaches for degenerative cervical myelopathy...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28628156/-atlantoaxial-reduction-and-fixation-guided-by-the-intraoperative-ct
#8
(no author information available yet)
OBJECTIVE: To evaluate the clinical result of atlantoaxial reduction and fixation guided by the intraoperative CT. METHODS: Sixteen cases were retrospectively studied, including seven males and nine females, with the mean age of 49.9 years. Twelve cases were diagnosed as chronic atlantoaxial instability or dislocation, while four cases as acute odontoid fracture and dislocation. Among the sixteen cases, fourteen underwent atlantoaxial fusion, while two underwent temporary atlantoaxial fixation without fusion...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28625909/multilevel-acdf-with-zero-profile-devices-analysis-of-safety-and-feasibility-with-a-focus-on-sagittal-alignment-and-its-impact-on-clinical-outcome-a-single-institution-experience-and-review-of-the-literature
#9
Vincenzo Albanese, Francesco Certo, Massimiliano Visocchi, Giuseppe Mv Barbagallo
BACKGROUND: In multilevel degenerative conditions posterior approaches are often preferred, but anterior approaches provide comparable clinical results and better alignment. Anterior plating entails higher rates of soft tissue injuries and dysphagia, particularly in multilevel cases. This study evaluates efficacy and safety of zero-profile devices in three and four-level ACDF, analyzing patients' clinical and radiological long-term outcome. METHODS: We prospectively enrolled 24 patients with cervical spondylotic myeloradiculopathy (CSM), who underwent three and four-level ACDF with Zero-P device...
June 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28625905/the-influence-of-mri-features-on-surgical-decision-making-in-degenerative-cervical-myelopathy-results-from-a-global-survey-of-aospine-international-members
#10
Aria Nouri, Allan R Martin, Anick Nater, Christopher D Witiw, So Kato, Lindsay Tetreault, Hamed Reihani-Kermani, Carlo Santaguida, Michael G Fehlings
OBJECTIVE: We conducted a survey to understand how specific pathologic features on MRI influence surgeons toward an anterior or posterior surgical approach in Degenerative Cervical Myelopathy (DCM) . METHODS: A questionnaire was sent out to 6,179 AOSpine International members via email. This included 18 questions on a 7-point Likert scale regarding how MRI features influence the respondent's decision to perform an anterior or posterior surgical approach. Influence was classified based on the mean and mode...
June 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28623403/diffusion-tensor-imaging-can-predict-surgical-outcomes-of-patients-with-cervical-compression-myelopathy
#11
Satoshi Maki, Masao Koda, Mitsuhiro Kitamura, Taigo Inada, Koshiro Kamiya, Mitsutoshi Ota, Yasushi Iijima, Junya Saito, Yoshitada Masuda, Koji Matsumoto, Masatoshi Kojima, Takayuki Obata, Kazuhisa Takahashi, Masashi Yamazaki, Takeo Furuya
PURPOSE: The aim of this study was to assess the potential role of diffusion tensor imaging (DTI) as a predictor of surgical outcomes in patients with cervical compressive myelopathy (CCM). Surgical decompression is often recommended for symptomatic CCM. It is important to know the prognosis of surgical outcomes and to recommend appropriate timing for surgery. METHODS: We enrolled 26 patients with CCM who underwent surgery. The Japanese Orthopaedic Association (JOA) score for cervical myelopathy was evaluated before and 6 months after surgery...
June 16, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28620788/comparison-of-intraoperative-neurophysiologic-monitoring-outcomes-between-cervical-and-thoracic-spine-surgery
#12
Shujie Wang, Yuan Tian, Xiangquan Lin, Zhifu Ren, Yu Zhao, Jiliang Zhai, Xiaojuan Zhang, Yanwei Zhao, Yingyue Dong, Congran Zhao, Ye Tian
PURPOSE: The objective is to compare the intraoperative monitoring (IOM) outcomes between degenerative cervical and thoracic spine decompression surgery. METHOD: A total of 97 patients with cervical compression myelopathy (CCM) and 75 patients with thoracic compression myelopathy (TCM) were prospectively collected between December 2012 and June 2015 in our spine center. Somatosensory-evoked potentials (SSEP) and motor-evoked potentials (MEP) were used for IOM. The postoperative neurologic status of each patient was assessed immediately after surgery...
June 15, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28619491/the-accuracy-of-multimodality-intraoperative-neuromonitoring-to-predict-postoperative-neurological-deficits-following-cervical-laminoplasty
#13
Junichi Oya, John F Burke, Todd Vogel, Boby Tay, Dean Chou, Praveen Mummaneni
BACKGROUND: Intraoperative neuromonitoring (IONM) has been reported to be sensitive and specific in the detection of neurological injury during spinal surgery. However, utilizing multimodality IONM to predict postoperative neural deficits following cervical laminoplasty remains unclear. OBJECTIVE: The purpose of this study is to clarify the incidence of C5 palsy utilizing multimodality IONM and to compare the accuracy of multimodality IONM to predict postoperative C5 palsy against isolated transcranial motor-evoked potential (MEP)...
June 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28615198/polymorphic-nature-of-htlv-1-particle-cores-as-revealed-through-characterization-of-a-chronically-infected-cell-line
#14
Morgan E Meissner, Luiza Mendonça, Wei Zhang, Louis M Mansky
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 cell-to-cell transmission is dependent on the release of infectious virus particles into the virological synapse. HTLV-1 particle structure is still poorly understood, and previous studies have analyzed viruses produced by transformed lymphocytic cell lines chronically infected with HTLV-1, particularly the MT-2 cell line, which harbors truncated proviruses and expresses aberrant forms of the Gag protein...
June 14, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28614282/clinical-outcomes-of-cervical-spinal-surgery-for-cervical-myelopathic-patients-with-coexisting-lumbar-spinal-canal-stenosis-tandem-spinal-stenosis-a-retrospective-analysis-of-297-cases
#15
Tsuyoshi Yamada, Toshitaka Yoshii, Naoki Yamamoto, Takashi Hirai, Hiroyuki Inose, Tsuyoshi Kato, Shigenori Kawabata, Atsushi Okawa
STUDY DESIGN: Retrospective observational study. OBJECTIVE: We evaluated the prevalence and clinical characteristics of tandem spinal stenosis (TSS) in patients with cervical myelopathy including ossification of the posterior longitudinal ligament of the cervical spine (C-OPLL). SUMMARY OF BACKGROUND DATA: Concurrent cervical and lumbar spinal canal stenosis is generally reported as TSS. Most previous studies have used magnetic resonance imaging to evaluate spinal stenosis in the cervical and lumbar spine...
June 13, 2017: Spine
https://www.readbyqxmd.com/read/28614280/psychometric-validation-of-the-adapted-traditional-chinese-hong-kong-version-of-the-japanese-orthopaedic-association-cervical-myelopathy-evaluation-questionnaire-joacmeq
#16
Prudence Wing Hang Cheung, Carlos King Ho Wong, Sin Ting Lau, Jason Pui Yin Cheung
STUDY DESIGN: Prospective questionnaire translation and validation. OBJECTIVE: To translate and cross-culturally adapt the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) into Traditional Chinese (Hong Kong); and to assess its validity, reliability and sensitivity for differentiating cervical myelopathy (CM) and presence of acute neck/shoulder pain. SUMMARY OF BACKGROUND DATA: CM frequently presents with various symptoms affecting patients' quality of life...
June 13, 2017: Spine
https://www.readbyqxmd.com/read/28608127/downregulation-of-histone-methyltransferase-ehmt2-in-cd4-t-cells-may-protect-htlv-1-infected-individuals-against-ham-tsp-development
#17
Camila Schoueri Colaço, Adriano Reis de Matos, Martha Silva Estrêla, Maurício Cristiano Rocha-Júnior, Kátia Kaori Otaguiri, Evandra Strazza Rodrigues, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas, Simone Kashima, Fabio Pittella Silva, Rodrigo Haddad
Approximately 5% of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals will develop one of the HTLV-1-related diseases, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T-cell leukemia. However, the mechanisms responsible for the appearance of symptoms have not been fully clarified. It is believed that viral factors, host genetic and epigenetic mechanisms are implicated in this process. Studies have shown the involvement of histone methyltransferases in retrovirus infection, but no study observed their expression in HTLV-1-infected patients...
June 12, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28607826/socioeconomic-and-regional-differences-in-the-treatment-of-cervical-spondylotic-myelopathy
#18
Sheri K Palejwala, Anand I Rughani, G Michael Lemole, Travis M Dumont
BACKGROUND: Cervical spondylotic myelopathy (CSM) is the leading cause of spinal cord dysfunction in the world. Surgical treatment is both medically and economically advantageous, and can be achieved through multiple approaches, with or without fusion. We used the Nationwide Inpatient Sample (NIS) database to better elucidate regional and socioeconomic variances in the treatment of CSM. METHODS: The NIS database was queried for elective admissions with a primary diagnosis of CSM (ICD-9 721...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28606250/-three-dimensional-finite-element-model-of-a-modified-posterior-cervical-single-open-door-laminoplasty
#19
Q Wang, Y Yang, Q Fei, D Li, J J Li, H Meng, N Su, Z H Fan, B Q Wang
Objective: To build a three-dimensional finite element models of a modified posterior cervical single open-door laminoplasty with short-segmental lateral mass screws fusion. Methods: The C(2)-C(7) segmental data were obtained from computed tomography (CT) scans of a male patient with cervical spondylotic myelopathy and spinal stenosis.Three-dimensional finite element models of a modified cervical single open-door laminoplasty (before and after surgery) were constructed by the combination of software package MIMICS, Geomagic and ABAQUS...
June 6, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28604489/risk-factors-and-prognosis-for-acute-progression-of-myelopathic-symptoms-in-patients-with-ossification-of-the-posterior-longitudinal-ligament-after-minor-trauma
#20
Jong-Myung Jung, Chun Kee Chung, Chi Heon Kim, Yunhee Choi
STUDY DESIGN: Retrospective Cohort study. OBJECTIVE: To identify the risk factors for acute progression of myelopathic symptoms (PMS) associated with ossification of the posterior longitudinal ligament (OPLL) after minor trauma and to compare the prognosis between an acute PMS group and a chronic PMS group. SUMMARY OF BACKGROUD DATA: Although the prevalence of OPLL among patients with cervical myelopathy is high, few studies have been published regarding the risk factors for acute PMS associated with OPLL after minor trauma...
June 9, 2017: Spine
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