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https://www.readbyqxmd.com/read/29788751/radiographic-analysis-of-the-correlation-between-ossification-of-the-nuchal-ligament-and-sagittal-alignment-and-segmental-stability-of-the-cervical-spine-in-patients-with-cervical-spondylotic-myelopathy
#1
Jinwei Ying, Honglin Teng, Yunfan Qian, Yingying Hu, Tianyong Wen, Dike Ruan, Minyu Zhu
Background Ossification of the nuchal ligament (ONL) caused by chronic injury to the nuchal ligament (NL) is very common in instability-related cervical disorders. Purpose To determine possible correlations between ONL, sagittal alignment, and segmental stability of the cervical spine. Material and Methods Seventy-three patients with cervical spondylotic myelopathy (CSM) and ONL (ONL group) and 118 patients with CSM only (control group) were recruited. Radiographic data included the characteristics of ONL, sagittal alignment and segmental stability, and ossification of the posterior longitudinal ligament (OPLL)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29788447/varicella-zoster-virus-induces-nuclear-translocation-of-the-neurokinin-1-receptor-promoting-lamellipodia-formation-and-viral-spread-in-spinal-astrocytes
#2
Andrew N Bubak, Christina N Como, Anna M Blackmon, Seth Frietze, Teresa Mescher, Dallas Jones, Randall J Cohrs, Petr Paucek, Nicholas L Baird, Maria A Nagel
Background: Varicella zoster virus (VZV) can present as a myelopathy with spinal astrocyte infection. Recent studies support a role for the neurokinin-1 receptor (NK-1R) in virus infections, as well as for cytoskeletal alterations that may promote viral spread. Thus, we examined the role of NK-1R in VZV-infected primary human spinal astrocytes (HA-sps) to shed light on the pathogenesis of VZV myelopathy. Methods: Mock- and VZV-infected HA-sps were examined for substance P (subP) production, NK-1R localization, morphological changes and viral spread in the presence or absence of NK-1R antagonists, aprepitant and rolapitant...
May 19, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29780055/postoperative-neck-symptoms-of-posterior-approach-for-cervical-compressive-myelopathy-expansive-open-door-laminoplasty-vs-segmental-partial-laminectomy
#3
Koji Otani, Masumi Iwabuchi, Katsuhiko Sato, Shinichi Konno, Shinichi Kikuchi
BACKGROUND: Laminoplasty is widely accepted as a standard treatment of cervical compressive myelopathy. However, due to the risk of postoperative complications such as neck symptoms, segmental partial laminectomy (SPL) is performed instead, which results in fewer postoperative symptoms. The aim of this study was to describe the difference in the incidence and severity of postoperative neck symptoms between traditional C3-C7 expansive open-door laminoplasty (ELAP) and SPL. METHODS: A retrospective and comparative study was performed regarding neck complications following the two surgical procedures...
May 18, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29775766/miyazaki-syndrome-due-to-ventriculoperitoneal-shunt-treatment-a-case-report
#4
Anita Kovács, Tamás Németh, Angéla Csomor, Tímea Novák, Ferenc Kövér, Erika Vörös
The signs and pathomechanism of Miyazaki syndrome is presented through the case of a young female patient. The patient underwent placement of a ventriculoperitoneal (VP) shunt with a pressure-adjustable valve for communicating hydrocephalus years before presenting to our department with the complaints of constant headache and unsteady gait. On the basis of the clinical picture and her history, plain and contrast-enhanced cranial and whole spine magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) examinations were performed, with the scans revealing signs indicative of cerebrospinal fluid (CSF) hypotension typical of Miyazaki syndrome...
May 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29770929/two-cases-of-sarcoidosis-presenting-as-longitudinally-extensive-transverse-myelitis
#5
REVIEW
Amanda Mary Scott, Janeth Yinh, Timothy McAlindon, Robert Kalish
Neurosarcoidosis is uncommon with an incidence of approximately 5 to 15%. Central nervous system involvement can be divided into brain and spinal cord neurosarcoidosis. Spinal cord sarcoidosis is extremely rare, occurring in less than 1% of all sarcoidosis cases. Its manifestations may include cauda equina syndrome, radiculopathy, syringomyelia, cord atrophy, arachnoiditis, and myelopathy or transverse myelitis. We highlight two cases of spinal cord sarcoidosis, each presenting with longitudinally extensive transverse myelitis, that demonstrate the dilemmas that physicians face with regard to diagnosis and treatment...
May 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29768548/balance-functional-mobility-and-fall-occurrence-in-patients-with-human-t-cell-lymphotropic-virus-type-1-associated-myelopathy-tropical-spastic-paraparesis-a-cross-sectional-study
#6
Erika Pedreira da Fonseca, Katia Nunes Sá, Rebeca Freitas Reis Nunes, Antônio Carlos Ribeiro Junior, Síntia Freitas Bastos Lira, Elen Beatriz Pinto
INTRODUCTION: Human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) may lead to reduced functional mobility and balance. It is important to establish specific parameters that identify these changes and predict the risk of falls in these patients. The aim was to compare balance, functional mobility, and occurrence of falls among patients with and without HAM/TSP and to suggest values to predict the risk of falls in these patients. METHODS: A cross-sectional study in patients with and without HAM/TSP involved balance assessments based on the berg balance scale (BBS) and functional mobility evaluation based on the timed up and go (TUG) test...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768358/spastic-paraparesis-caused-by-x-linked-adrenoleukodystrophy-mimicking-vacuolar-myelopathy-in-a-human-immunodeficiency-virus-patient-a-case-report
#7
Jin-Sung Park, Donghwi Park
RATIONALE: Vacuolar myelopathy is one of most common cause of spastic paresis in patients with human immunodeficiency virus (HIV) infection. However, X-linked adrenoleukodystrophy (X-ALD), which is a metabolic disorder caused by impairment of peroxisomal beta-oxidation of very-long-chain fatty acids (VLCFA), also manifests as various neurological deteriorations including adult onset spastic paraparesis. To the best of our knowledge, there has been no report of newly developed spastic paresis due to X-ALD in a patient with HIV infection...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29762925/association-between-myxomatous-mitral-valve-disease-and-skeletal-back-abnormalities
#8
Alireza Movahed, David Majdalany, Marc Gillinov, William Schiavone
BACKGROUND: Myxomatous mitral valve disease (MMVD) is one of the most prevalent valvular heart diseases, while back pain, neck pain and upper-extremity numbness are some of the most common complaints in outpatient settings. Decreased thoracic kyphosis (straight back) is a known cause of hastening back or neck problems, radiculopathy, or even myelopathy. The study aim was to examine the relationship between MMVD, straight back, and the need for cervical fusion. METHODS: In this single-center retrospective study, patients who underwent mitral valve repair or replacement due to MMVD (cases) based on age, gender and body mass index (BMI), were matched with patients who underwent coronary artery bypass grafting (CABG) surgery and had no history of mitral valve disease (controls)...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29761297/severe-neurologic-complications-of-immune-checkpoint-inhibitors-a-single-center-review
#9
Sarah Mancone, Thomas Lycan, Tamjeed Ahmed, Umit Topaloglu, Andrew Dothard, William J Petty, Roy E Strowd
BACKGROUND: Immune checkpoint inhibitors (ICIs) are a promising class of anticancer drugs associated with immune-related adverse events (IRAEs). In registration studies of selected cancer populations, neurologic IRAEs were rare. Post-marketing experience describing their prevalence in clinical practice continues to be reported. METHODS: A retrospective cohort of patients treated at our institution with ICIs from 2005 to 2017 was identified. Patients with new neurologic ICD codes documented during or after ICI treatment were enrolled...
May 14, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29755242/spinal-schistosomiasis-cases-in-egyptian-population
#10
Ahmed M Ashour, Tarek H Elserry, Mohamed S Nosser, Zeyad Y Fayed, Mohamed Wael Samir, Alaa Fakher, Maamoun M Ashour, Mamdouh M Salama
Background: Spinal cord involvement by schistosomiasis is considered to be rare. Clinical presentation of spinal schistosomiasis ranges from radicular pain to myelopathy causing flaccid paraplegia, bladder incontinence, and dysesthesia. We reported six cases with spinal schistosomiasis. Methodology: We did a retrospective analysis of the records in our department from March 1995 to March 2015, and we found that six cases of proved spinal schistosomiasis were documented, with follow-up period more than a year, aiming to find an assumption for a guideline for this ambiguous issue...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29755239/type-iii-odontoid-fractures-a-subgroup-analysis-of-complex-high-energy-fractures-treated-with-external-immobilization
#11
Thomas E Niemeier, Adam R Dyas, Sakthivel R Manoharan, Steven M Theiss
Study Design: Retrospective cohort study. Objective: Type III odontoid fractures are classically treated nonoperatively, yet, the current literature on Type III odontoid fractures includes fractures of multiple etiologies and fracture morphologies. We hypothesize that a subgroup of complex, Type III fractures caused by high-energy mechanisms are more likely to fail nonoperative treatment. Materials and Methods: Acute Type III odontoid fractures were identified at a single institution from 2008 to 2015...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29755235/unusual-cause-of-high-cervical-myelopathy-c1-arch-stenosis
#12
Lokesh S Nehete, Dhananjay I Bhat, M S Gopalakrishnan, Dhaval Shukla, Subhas Konar, Prashant Singh, Bhagavatula Indira Devi
Introduction: High cervical myelopathy can be rarely caused by the developmental anomalies of atlas. Patients with C1 arch stenosis can present in early childhood or later in life. In symptomatic patients, posterior decompression at atlas is mandatory. We report the first clinical series of 20 patients of C1 arch stenosis in the English literature. Materials and Methods: This is retrospective case series having a cohort of 20 patients with congenital C1 arch stenosis...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29753081/postoperative-changes-in-moderate-to-severe-nonspecific-low-back-pain-after-cervical-myelopathy-surgery
#13
Chi Heon Kim, Chun Kee Chung, Urim Lee, Yunhee Choi, Sung Bae Park, Jong-Myung Jung, Sung Hwan Hwang, Seung Heon Yang
OBJECTIVE: Cervical myelopathy patients sometimes experience concurrent nonspecific moderate to severe low back pain (msLBP). However, postoperative changes in msLBP after cervical myelopathy surgery have rarely been reported. Awareness of postoperative changes in msLBP may be helpful in consultation. Therefore, the objective of this study was to examine postoperative changes in msLBP. METHODS: Patients with cervical myelopathy and msLBP (a visual analog pain score ≥ 5/10) were prospectively reviewed, and 53 patients (M:F, 28:25; mean age, 63...
May 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29752520/mucopolysaccharidoses-overview-of-neuroimaging-manifestations
#14
Manal Nicolas-Jilwan, Moeenaldeen AlSayed
The mucopolysaccharidoses are a heterogeneous group of inherited lysosomal storage disorders, characterized by the accumulation of undegraded glycosaminoglycans in various organs, leading to tissue damage. Mucopolysaccharidoses include eight individual disorders (IS [Scheie syndrome], IH [Hurler syndrome], II, III, IV, VI, VII and IX). They have autosomal-recessive transmission with the exception of mucopolysaccharidosis II, which is X-linked. Each individual disorder has a wide spectrum of phenotypic variation, depending on the specific mutation, from very mild to very severe...
May 11, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29751126/radiological-follow-up-after-implanting-cervical-disc-prosthesis-in-anterior-discectomy-a-systematic-review
#15
REVIEW
Xiaoyu Yang, Tessa Janssen, Mark P Arts, Wilco C Peul, Carmen L A Vleggeert-Lankamp
Objective The objective of this study was to review current literature on comparison of radiological outcome of cervical arthroplasty with fusion after anterior discectomy for radiculopathy. Methods A literature search was performed in PubMed, Embase, Web of Science, COCHRANE, CENTRAL and CINAHL using a sensitive search string combination. Studies were selected by predefined selection criteria (a.o. patients exclusively suffering from cervical radiculopathy) and risk of bias was assessed using a validated Cochrane Checklist adjusted for this purpose...
May 8, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29749801/treatment-of-atlantoaxial-dislocations-among-patients-with-cervical-osseous-or-vascular-abnormalities-utilizing-hybrid-techniques
#16
Shenglin Wang, Yinglun Tian, Bassel G Diebo, Samantha R Horn, Peter G Passias
OBJECTIVE Most cervical fixations for atlantoaxial dislocation (AAD) are bilateral and symmetric; however, in the setting of osseous and vascular deformity at the craniovertebral junction, asymmetrical and hybrid fixations are used as "salvage" techniques. Because of the rarity of these cases, hybrid cervical fixations for AAD have not been fully explored. The aim of this study was to evaluate the clinical feasibility and outcomes of posterior hybrid cervical fixations for AAD. METHODS Twenty-one AAD cases were retrospectively studied; 18 had cervical myelopathy with Japanese Orthopaedic Association (JOA) scores ranging from 9 to 16 (mean 13...
May 11, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29748208/relationship-between-cough-associated-changes-in-csf-flow-and-disease-severity-in-chiari-i-malformation-an-exploratory-study-using-real-time-mri
#17
A F Bezuidenhout, D Khatami, C B Heilman, E M Kasper, S Patz, N Madan, Y Zhao, R A Bhadelia
BACKGROUND AND PURPOSE: Currently no quantitative objective test exists to determine disease severity in a patient with Chiari I malformation. Our aim was to correlate disease severity in symptomatic patients with Chiari I malformation with cough-associated changes in CSF flow as measured with real-time MR imaging. MATERIALS AND METHODS: Thirteen symptomatic patients with Chiari I malformation (tonsillar herniation of ≥5 mm) were prospectively studied. A real-time, flow-sensitized pencil-beam MR imaging scan was used to measure CSF stroke volume during rest and immediately following coughing and relaxation periods (total scan time, 90 seconds)...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29746965/spine-and-lower-extremity-kinematics-during-gait-in-cervical-spondylotic-myelopathy-patients
#18
Ram Haddas, Sujal Patel, Raj Arakal, Akwasi Boah, Theodore Belanger, Kevin L Ju
BACKGROUND CONTEXT: CSM typically manifests with a slow, progressive stepwise decline in neurologic function, including hand clumsiness and balance difficulties. Gait disturbances are frequently seen in CSM patients, with more advanced cases exhibiting a stiff, spastic gait. PURPOSE: To evaluate the spatiotemporal parameters and spine and lower extremity kinematics during the gait cycle of adult cervical spondylotic myelopathy (CSM) patients prior to surgical intervention...
May 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29746963/patient-phenotypes-associated-with-outcome-following-surgery-for-mild-degenerative-cervical-myelopathy-a-principal-component-regression-analysis
#19
Jetan H Badhiwala, Christopher Witiw, Farshad Nassiri, Blessing Jaja, Muhammad A Akbar, Alireza Mansouri, Zamir Merali, George M Ibrahim, Jefferson R Wilson, Michael G Fehlings
BACKGROUND CONTEXT: Predictors of outcome after surgery for degenerative cervical myelopathy (DCM) have been determined previously through hypothesis-driven multivariate statistical models that rely on a priori knowledge of potential confounders, exclude potentially important variables due to restrictions in model building, cannot include highly collinear variables in the same model, and ignore intrinsic correlations among variables. PURPOSE: To apply a data-driven approach to identify patient phenotypes that may predict outcomes after surgery for mild DCM...
May 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29746262/clinical-comparison-of-surgical-constructs-for-anterior-cervical-corpectomy-and-fusion-in-patients-with-cervical-spondylotic-myelopathy-or-ossified-posterior-longitudinal-ligament-a-systematic-review-and-meta-analysis
#20
Timothy R Niedzielak, Joseph Palmer, John P Malloy
STUDY DESIGN: This is a systematic review and meta-analysis. OBJECTIVE: To examine the differences in outcomes among current constructs and techniques for anterior cervical corpectomy and fusion (ACCF) in patients with single or multiple level cervical myelopathy (CM) secondary to cervical spondylosis or ossified posterior longitudinal ligament. SUMMARY OF BACKGROUND DATA: The natural history of CM can be a progressive disease process. In such cases, where surgical decompression is indicated to halt the progression, ACCF is typically chosen for pathology located posterior to the vertebral body...
May 9, 2018: Clinical Spine Surgery
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