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https://www.readbyqxmd.com/read/28808212/recent-advances-in-arsenic-trioxide-encapsulated-nanoparticles-as-drug-delivery-agents-to-solid-cancers
#1
Anam Akhtar, Scarlet Xiaoyan Wang, Lucy Ghali, Celia Bell, Xuesong Wen
Since arsenic trioxide was first approved as the front line therapy for acute promyelocytic leukemia 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of arsenic trioxide in treating hematological cancers have not been translated to solid cancers. This is due to arsenic's rapid clearance by the body's immune system before reaching the tumor site. Several attempts have henceforth been made to increase its bioavailability toward solid cancers without increasing its dosage albeit without much success...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28808204/safety-immunogenicity-and-cross-species-protection-of-a-plasmid-dna-encoding-plasmodium-falciparum-sera5-polypeptide-microbial-epitopes-and-chemokine-genes-in-mice-and-olive-baboons
#2
Nyamongo Onkoba, Ruth M Mumo, Horace Ochanda, Charles Omwandho, Hastings S Ozwara, Thomas G Egwang
Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of strain-transcending malarial vaccines. The present study sought to determine safety, immunogenicity and cross-species efficacy ofPlasmodium falciparum serine repeat antigen 5 polypeptide co-expressed with epitopes of Bacille-Calmette Guerin (BCG), tetanus toxoid (TT) and a chemokine gene. Olive baboons and BALB/c mice were randomly assigned into vaccine and control groups. The vaccine group animals were primed and boosted twice with pIRES plasmids encoding the SERA5+ BCG+ TT alone, or with either CCL5 or CCL20 and the control group with pIRES plasmid vector backbone...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28796812/toxicological-and-bio-distribution-profile-of-a-gm-csf-expressing-double-targeted-chimeric-oncolytic-adenovirus-oncos-102-support-for-clinical-studies-on-advanced-cancer-treatment
#3
Lukasz Kuryk, Lotta Vassilev, Tuuli Ranki, Akseli Hemminki, Aila Karioja-Kallio, Onerva Levälampi, Antti Vuolanto, Vincenzo Cerullo, Sari Pesonen
The purpose of this work was to carry out preclinical toxicity and bio-distribution studies required for regulatory approval of a clinical trial application for Phase I clinical studies of ONCOS-102 (Ad5/3-D24-GM-CSF) for therapy of advanced cancers (NCT01598129). The study design, route of administration and dosage differs from the clinical protocol and in more detail, investigate bio-distribution and toxicological profile of ONCOS-102 treatment in animal model. The study was carried out in 300 hamsters divided into nine test groups-three bio-distribution groups and six groups for analysis of toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28783210/monocyte-count-at-onset-predicts-post-stroke-outcomes-during-a-90-day-follow-up
#4
Luca Liberale, Fabrizio Montecucco, Aldo Bonaventura, Ilaria Casetta, Silva Seraceni, Alessandro Trentini, Marina Padroni, Franco Dallegri, Enrico Fainardi, Federico Carbone
BACKGROUND: Acute ischemic stroke (AIS) triggers both systemic and neurovascular inflammation, influencing post-stroke recovery. In smokers with AIS inflammation might be further upregulated, increasing ischemia/reperfusion injury. Here, the predictive value of leukocyte and adhesion molecules levels on post-stroke outcomes was investigated. MATERIALS AND METHODS: 89 patients with AIS (n=30 smokers and n=59 non-smokers) were recruited and evaluated 1, 7 and 90 days after the onset to assess stroke severity by the National Institute of Health Stroke Scale (NIHSS) score as well as clinical recovery at 90 day by the modified Rankin Scale (mRS)...
August 7, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28781207/testing-of-an-oral-dosing-technique-for-double-crested-cormorants-phalacocorax-auritus-laughing-gulls-leucophaeus-atricilla-homing-pigeons-columba-livia-and-western-sandpipers-calidris-mauri-with-artificially-weather-mc252-oil
#5
K M Dean, D Cacela, M W Carney, F L Cunningham, C Ellis, A R Gerson, C G Guglielmo, K C Hanson-Dorr, K E Harr, K A Healy, K E Horak, J P Isanhart, L V Kennedy, J E Link, I Lipton, A K McFadden, J K Moye, C R Perez, C A Pritsos, K L Pritsos, T Muthumalage, S A Shriner, S J Bursian
Scoping studies were designed to determine if double-crested cormorants (Phalacocorax auritus), laughing gulls (Leucophaues atricilla), homing pigeons (Columba livia) and western sandpipers (Calidris mauri) that were gavaged with a mixture of artificially weathered MC252 oil and food for either a single day or 4-5 consecutive days showed signs of oil toxicity. Where volume allowed, samples were collected for hematology, plasma protein electrophoresis, clinical chemistry and electrolytes, oxidative stress and organ weigh changes...
August 3, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28757461/safety-assessment-of-urolithin-a-a-metabolite-produced-by-the-human-gut-microbiota-upon-dietary-intake-of-plant-derived-ellagitannins-and-ellagic-acid
#6
Jacqueline Heilman, Pénélope Andreux, Nga Tran, Chris Rinsch, William Blanco-Bose
Urolithins are metabolites produced in the gut following consumption of ellagitannin and ellagic acid rich foods such as pomegranate, nuts and certain berries. Urolithin A (UA) is one of the predominant isoforms of urolithins in humans and has demonstrated interesting biological activities, suggesting potential benefits of direct consumption of UA. However, an evaluation of the safety of direct administration of UA has not yet been published. The aim of this study was to investigate for the first time the genotoxicity, toxicokinetics, and repeated dose safety of orally administered synthetic UA in rats...
July 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28753729/safety-evaluation-of-green-tea-polyphenols-consumption-in-middle-aged-ovariectomized-rat-model
#7
Chwan-Li Shen, Gordon Brackee, Xiao Song, Michael D Tomison, VelvetLee Finckbone, Kelly T Mitchell, Lili Tang, Ming-Chien Chyu, Dale M Dunn, Jia-Sheng Wang
This work evaluates chronic safety in middle-aged ovariectomized rats supplemented with different dosages of green tea polyphenols (GTP) in drinking water. The experiment used 6-mo-old sham (n = 39) and ovariectomized (OVX, n = 143) female rats. All sham (n = 39) and 39 of the OVX animals received no GTP treatment and their samples were collected for outcome measures at baseline, 3 mo, and 6 mo (n = 13 per group for each). The remaining OVX animals were randomized into 4 groups receiving 0.15%, 0.5%, 1%, and 1...
July 28, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28749274/evaluation-of-the-i-stat-portable-clinical-analyzer-for-measurement-of-ionized-calcium-and-selected-blood-chemistry-values-in-asian-elephants-elephas-maximus
#8
Danielle K Tarbert, Erica Behling-Kelly, Heather Priest, Sara Childs-Sanford
Thei-STAT® portable clinical analyzer (PCA) provides patient-side results for hematologic, biochemical, and blood gas values when immediate results are desired. This analyzer is commonly used in nondomestic animals; however, validation of this method in comparison with traditional benchtop methods should be performed for each species. In this study, the i-STAT PCA was compared with the Radiometer ABL 800 Flex benchtop analyzer using 24 heparinized whole blood samples obtained from healthy E. maximus . In addition, the effect of sample storage was evaluated on the i-STAT PCA...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28693297/evaluation-of-a-fixed-dose-combination-of-benazepril-and-pimobendan-in-dogs-with-congestive-heart-failure-a-randomized-non-inferiority-clinical-trial
#9
Jonathan N King, Atsushi Hirakawa, Junko Sonobe, Hiroshi Otaki, Nobuhiro Sakakibara, Wolfgang Seewald, Sophie Forster
A new fixed dose combination tablet of benazepril and pimobendan (Fortekor Plus) was tested in dogs with congestive heart failure (CHF) caused by myxomatous mitral valve disease (MMVD) in a prospective, multi-center, parallel-group, three-arm, masked, randomized, non-inferiority clinical trial in 67 dogs in Japan. The test group received Fortekor Plus twice daily (n=34). Two control groups received the registered formulations of benazepril (Fortekor) and pimobendan (Vetmedin) with administration of pimobendan twice daily and benazepril twice (Control I, n=14) or once (Control II, n=19) daily...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28680362/medical-biochemistry-as-subdiscipline-of-laboratory-medicine-in-serbia
#10
Snežana Jovičić, Nada Majkić-Singh
Medical biochemistry is the usual name for clinical biochemistry or clinical chemistry in Serbia, and medical biochemist is the official name for the clinical chemist (or clinical biochemist). This is the largest sub-discipline of the laboratory medicine in Serbia. It includes all aspects of clinical chemistry, and also laboratory hematology with coagulation, immunology, etc. Medical biochemistry laboratories in Serbia and medical biochemists as a profession are part of Health Care System and their activities are regulated through: the Health Care Law and rules issued by the Chamber of Medical Biochemists of Serbia...
April 2017: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28663032/a-90-day-oral-toxicity-study-of-glycolipids-from-dacryopinax-spathularia-in-cd-%C3%A2-rats
#11
Jens Bitzer, Thomas Henkel, Andrey I Nikiforov, Marisa O Rihner, J Leuschner
The subchronic toxicity of jelly mushroom glycolipids from Dacryopinax spathularia (herein referred to as "AM-1") was studied in Crl:CD(SD) rats. The test item was administered via the drinking water at concentrations of 1.5, 5.0 or 15 mg/mL for 90 days with an additional 4-week recovery period. No test article-related deaths, clinical observations or neurological effects were noted. Decreased drinking water consumption for mid- and high-dose groups was attributable to the reduced palatability of drinking water containing higher test article concentrations...
June 26, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28642866/evaluation-of-serum-for-pathophysiological-effects-of-prolonged-low-salinity-water-exposure-in-displaced-bottlenose-dolphins-tursiops-truncatus
#12
Ruth Y Ewing, Blair Mase-Guthrie, Wayne McFee, Forrest Townsend, Charles A Manire, Michael Walsh, Rose Borkowski, Gregory D Bossart, Adam M Schaefer
We conducted a retrospective study of serum biochemistry and hematologic findings from displaced, out-of-habitat bottlenose dolphins (Tursiops truncatus) exposed to various low salinity environments in waters along the southern United States including southeastern Atlantic and northern Gulf of Mexico. Serum sodium, chloride, and calculated osmolality were significantly lower and below reference ranges in displaced animals compared to free-ranging case control animals. This suggests clinical hyponatremia, hypochloremia, and hypo-osmolality due to an uptake of low saline water from the environment...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28633869/baccaurea-angulata-fruit-juice-ameliorates-altered-hematological-and-biochemical-biomarkers-in-diet-induced-hypercholesterolemic-rabbits
#13
Idris Adewale Ahmed, Maryam Abimbola Mikail, Muhammad Ibrahim
Hypercholesterolemia is an important risk factor linked to the alteration of blood hematology and clinical chemistry associated with the development and progression of atherosclerosis. Previous studies have demonstrated the safety and potential health benefits of Baccaurea angulata (BA) fruit. We hypothesized that the oral administration of BA fruit juice could ameliorate the alteration in the hematological and biochemical biomarkers of diet-induced hypercholesterolemic rabbits. The aim of this study was to investigate the effects of different doses of BA juice on the hematological and biochemical biomarkers in normo- and hypercholesterolemic rabbits...
June 2017: Nutrition Research
https://www.readbyqxmd.com/read/28627385/advances-in-antibody-drug-conjugates-a-new-era-of-targeted-cancer-therapy
#14
REVIEW
Samaresh Sau, Hashem O Alsaab, Sushil Kumar Kashaw, Katyayani Tatiparti, Arun K Iyer
Antibody-drug conjugates (ADCs), a potent class of anticancer therapeutics, comprise a high-affinity antibody (Ab) and cytotoxic payload coupled via a suitable linker for selective tumor cell killing. In the initial phase of their development, two ADCs, Mylotarg(®), and Adcetris(®) were approved by the US Food and Drug Administration (FDA) for treating hematological cancer, but the real breakthrough came with the discovery of the breast cancer-targeting ADC, Kadcyla(®). With advances in bioengineering, linker chemistry, and potent cytotoxic payload, ADC technology has become a more powerful tool for targeted cancer therapy...
June 13, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28618975/a-black-cohosh-extract-causes-hematologic-and-biochemical-changes-consistent-with-a-functional-cobalamin-deficiency-in-female-b6c3f1-n-mice
#15
Michelle C Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E Kissling, Sukhdev S Brar, Dorian Olivera, Chad Blystone, Greg Travlos
Black cohosh rhizome, available as a dietary supplement, is most commonly marketed as a remedy for dysmenorrhea and menopausal symptoms. A previous subchronic toxicity study of black cohosh dried ethanolic extract (BCE) in female mice revealed a dose-dependent ineffective erythropoiesis with a macrocytosis consistent with the condition known as megaloblastic anemia. The purpose of this study was to investigate potential mechanisms by which BCE induces these particular hematological changes. B6C3F1/N female mice (32/group) were exposed by gavage to vehicle or 1,000 mg/kg BCE for 92 days...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28608739/safety-of-repeated-dose-intratympanic-injections-with-am-101-in-acute-inner-ear-tinnitus
#16
Hinrich Staecker, Michael Morelock, Timothy Kramer, Pavel Chrbolka, Joong Ho Ahn, Thomas Meyer
Objective To evaluate the safety and tolerability of repeated intratympanic administration of the gel-formulated NMDA receptor antagonist AM-101 in acute patients with inner ear tinnitus. Study Design Prospective, double-blind, randomized, placebo-controlled study. Setting Sixty-nine secondary and tertiary sites in North America, Europe, and Asia. Subjects and Methods In total, 343 subjects with persistent acute tinnitus after traumatic cochlear injury or otitis media were randomized to receive 3 intratympanic doses of either AM-101 0...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28605433/sociodemographic-correlates-of-clinical-laboratory-test-expenditures-in-a-major-canadian-city
#17
Jocelyn Barber, Maggie Guo, Leonard T Nguyen, Roger Thomas, Tanvir Chowdhury Turin, Marcus Vaska, Christopher Naugler
Objectives: The increasing cost of clinical laboratory testing is a challenge in our health care system. This study aims to calculate the annual clinical laboratory test costs attributed to patients in a major Canadian city and to correlate them to their sociodemographic variables. Methods: Retrospective cohort study involving patients who received clinical chemistry, hematology, and microbiology tests in 2011 in Calgary, Canada (n = 610,409). Test volumes were obtained from a laboratory informatics database...
June 12, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28602764/first-serological-evidence-of-hantavirus-among-febrile-patients-in-mozambique
#18
Ramalho Chau, Nilesh Bhatt, Ivan Manhiça, Sandra Cândido, Nilsa de Deus, Onélia Guiliche, Almiro Tivane, Lara Virgínia Evaristo, Alexandro Guterres, Vanessa Monteiro, Jorlan Fernandes de Jesus, Renata Carvalho Oliveira, Elba Regina de Lemos, Eduardo Samo Gudo
OBJECTIVE: The occurrence of hantavirus in Sub-Saharan Africa is poorly studied and its clinical implications are unknown. This study aimed to determine the occurrence of hantavirus infection among febrile patients attending an outpatient clinic at a primary health care center located in a suburban area of the city of Maputo in Mozambique. METHODS: Paired acute and convalescent samples from a total of 200 febrile patients aged >5years who were recruited between February 2012 and October 2014 were screened for IgM and IgG antibodies against hantavirus using an ELISA...
June 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28583666/safety-evaluation-of-water-soluble-palm-fruit-bioactives
#19
Barry S Lynch, Spencer West, Ashley Roberts
Water-soluble palm fruit bioactives, derived from the aqueous stream of palm oil processing, have shown anti-diabetogenic effects in rodent models. To assess the safety of potential incorporation of this polyphenol-containing material in food, in vitro bacterial reverse mutation and in vitro chromosome aberration assays were conducted along with a 90-day subchronic toxicity study in Sprague-Dawley rats. Water-soluble palm fruit bioactives were inactive in the Ames and in vitro chromosome aberration assays up to the limit doses of 5000 μg/plate and 5000 μg/mL, respectively...
June 2, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28546518/safety-immunogenicity-and-cross-species-protection-of-a-plasmid-dna-encoding-plasmodium-falciparum-sera5-polypeptide-microbial-epitopes-and-chemokine-genes-in-mice-and-olive-baboons
#20
Nyamongo Onkoba, Ruth M Mumo, Horace Ochanda, Charles Omwandho, Hastings S Ozwara, Thomas G Egwang
Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of strain-transcending malarial vaccines. The present study sought to determine safety, immunogenicity and cross-species efficacy ofPlasmodium falciparum serine repeat antigen 5 polypeptide co-expressed with epitopes of Bacille-Calmette Guerin (BCG), tetanus toxoid (TT) and a chemokine gene. Olive baboons and BALB/c mice were randomly assigned into vaccine and control groups. The vaccine group animals were primed and boosted twice with pIRES plasmids encoding the SERA5+ BCG+ TT alone, or with either CCL5 or CCL20 and the control group with pIRES plasmid vector backbone...
April 6, 2017: Journal of Biomedical Research
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