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clinical chemistry hematology

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https://www.readbyqxmd.com/read/27912126/evaluation-of-the-inactivation-effect-of-triton-x-100-on-ebola-virus-infectivity
#1
Francesca Colavita, Serena Quartu, Eleonora Lalle, Licia Bordi, Daniele Lapa, Silvia Meschi, Antonella Vulcano, Antonietta Toffoletti, Eugenio Bordi, Maria Grazia Paglia, Antonino Di Caro, Giuseppe Ippolito, Maria Rosaria Capobianchi, Concetta Castilletti
BACKGROUND: The recent Ebola virus disease outbreak occurred in West Africa since December 2013 highlighted the need of appropriate virus inactivation procedures to be set up to allow the necessary processing of specimens outside BSL-4 facilities and to perform laboratory tests without affecting clinical decisions. For this purpose, international guidelines suggest the pre-treatment of the samples with Triton X-100. OBJECTIVES: Due to the limited scientific evidence about the efficacy of Triton X-100 on enveloped-viruses, the aim of this work was to evaluate the effect of Triton X-100 on the virus infectivity and to establish the optimal conditions for its use...
November 22, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27909986/toxicity-and-pharmacokinetic-profile-for-single-dose-injection-of-aby-029-a-fluorescent-anti-egfr-synthetic-affibody-molecule-for-human-use
#2
Kimberley S Samkoe, Jason R Gunn, Kayla Marra, Sally M Hull, Karen L Moodie, Joachim Feldwisch, Theresa V Strong, Daniel R Draney, P Jack Hoopes, David W Roberts, Keith Paulsen, Brian W Pogue
PURPOSE: ABY-029, a synthetic Affibody peptide, Z03115-Cys, labeled with a near-infrared fluorophore, IRDye® 800CW, targeting epidermal growth factor receptor (EGFR) has been produced under good manufacturing practices for a US Food and Drug Administration-approved first-in-use human study during surgical resection of glioma, as well as other tumors. Here, the pharmacology, phototoxicity, receptor activity, and biodistribution studies of ABY-029 were completed in rats, prior to the intended human use...
December 1, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27905492/high-fidelity-computational-simulation-of-thrombus-formation-in-thoratec-heartmate-ii-continuous-flow-ventricular-assist-device
#3
Wei-Tao Wu, Fang Yang, Jingchun Wu, Nadine Aubry, Mehrdad Massoudi, James F Antaki
Continuous flow ventricular assist devices (cfVADs) provide a life-saving therapy for severe heart failure. However, in recent years, the incidence of device-related thrombosis (resulting in stroke, device-exchange surgery or premature death) has been increasing dramatically, which has alarmed both the medical community and the FDA. The objective of this study was to gain improved understanding of the initiation and progression of thrombosis in one of the most commonly used cfVADs, the Thoratec HeartMate II...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27863758/determination-of-reference-ranges-for-immature-platelet-and-reticulocyte-fractions-and-reticulocyte-hemoglobin-equivalent
#4
Iuri Vicente Camargo Morkis, Mariela Granero Farias, Luciana Scotti
INTRODUCTION: The immature platelet and immature reticulocyte fractions represent the ratios of platelets and reticulocytes recently released into the circulation and thus with higher RNA content. They are considered early indicators of bone marrow recovery. OBJECTIVE: The aim of this study was to determine the reference ranges for the immature platelet and reticulocyte fractions of hematologically normal individuals in a university hospital. METHODS: Venous blood samples collected in ethylenediaminetetraacetic acid K3 were analyzed using a Sysmex XE-5000™ analyzer...
October 2016: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/27855487/transfer-of-therapeutic-genes-into-fetal-rhesus-monkeys-using-recombinant-adeno-associated-type-i-viral-vectors
#5
Thomas J Conlon, Cathryn S Mah, Christina A R Pacak, Mary B Rucker Henninger, Kirsten E Erger, Marda L Jorgensen, Charles C Lee, Alice F Tarantal, Barry J Byrne
Neuromuscular disorders such as Pompe disease (glycogen storage disease, type II), result in early and potentially irreversible cellular damage with a very limited opportunity for intervention in the newborn period. Pompe disease is due to deficiency in acid α-glucosidase (GAA) leading to lysosomal accumulation of glycogen in all cell types, abnormal myofibrillogenesis, respiratory insufficiency, neurological deficits, and reduced contractile function in striated muscle. Previous studies have shown that fetal delivery of recombinant adeno-associated virus (rAAV) encoding GAA to the peritoneal cavity of Gaa-/- mice resulted in high-level transduction of the diaphragm...
November 17, 2016: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/27812172/adult-hematology-and-clinical-chemistry-laboratory-reference-ranges-in-a-zimbabwean-population
#6
Wadzanai P Samaneka, Gibson Mandozana, Willard Tinago, Nehemiah Nhando, Nyaradzo M Mgodi, Mutsawashe F Bwakura-Dangarembizi, Marshall W Munjoma, Zvenyika A R Gomo, Zvavahera M Chirenje, James G Hakim
BACKGROUND: Laboratory reference ranges used for clinical care and clinical trials in various laboratories in Zimbabwe were derived from textbooks and research studies conducted more than ten years ago. Periodic verification of these ranges is essential to track changes over time. The purpose of this study was to establish hematology and chemistry laboratory reference ranges using more rigorous methods. METHODS: A community-based cross-sectional study was carried out in Harare, Chitungwiza, and Mutoko...
2016: PloS One
https://www.readbyqxmd.com/read/27807617/randomized-controlled-clinical-trial-assessing-the-effects-of-oral-nutritional-supplements-in-postoperative-gastric-cancer-patients
#7
Fumihiko Hatao, Kuen-Yuan Chen, Jin-Ming Wu, Ming-Yang Wang, Susumu Aikou, Haruna Onoyama, Nobuyuki Shimizu, Kazuhiko Fukatsu, Yasuyuki Seto, Ming-Tsan Lin
BACKGROUND: Postoperative weight loss and malnutrition are major issues in gastric cancer patients. The concept of oral nutritional supplements (ONS) is gaining widespread acceptance. We investigated the effects of ONS administration on postoperative body weight loss in patients with gastric cancer who had undergone total gastrectomy or distal gastrectomy. METHODS: Patients were randomized to either the treatment or the control group. In both groups, standard surgery for gastric cancer was performed...
November 2, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27793534/plasmin-human-administration-in-acute-middle-cerebral-artery-ischemic-stroke-phase-1-2a-open-label-dose-escalation-safety-study
#8
Peter J Mitchell, Bernard Yan, Miroslav Brozman, Marc Ribo, Victor Marder, Kecia L Courtney, Jeffrey L Saver
BACKGROUND: This phase 1/2a, open-label, multicenter, dose-escalation, safety study describes the first evaluation of plasmin as an intracranial thrombolytic treatment for acute ischemic stroke in the middle cerebral artery. The rationale for intrathrombus administration is that plasmin would bind fibrin inside the targeted clot, protecting it from circulating inhibitors. METHODS: Plasmin was given in escalating doses within 9 hours of stroke onset, and treatment efficacy was determined in 5 patient cohorts (N = 40): cohort 1 (20 mg, ...
October 25, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27775063/the-effect-of-physiological-levels-of-south-african-puff-adder-bitis-arietans-snake-venom-on-blood-cells-an-in-vitro-model
#9
Morné A Strydom, Janette Bester, Sthembile Mbotwe, Etheresia Pretorius
A significant burden of illness is caused globally by snakebites particularly by the puff adder, Bitis arietans. Presently there is no reliable and rapid method to confirm envenomation on blood chemistry; although coagulation parameters like prothrombin time, partial thromboplastin time, international normalized ratio and also serum electrolytes are tested. Here, we found that direct in vitro exposure of physiological relevant whole venom levels to human healthy blood (N = 32), caused significant physiological changes to platelet activity using a hematology analyzer, and measuring occlusion time, as well as lyses time, with the global thrombosis test (GTT)...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27773843/using-tiletamine-zolazepam-xylazine-anesthesia-compared-to-co2-inhalation-for-terminal-clinical-chemistry-hematology-and-coagulation-analysis-in-mice
#10
Oksana N Khokhlova, Elena A Tukhovskaya, Irina N Kravchenko, Elena S Sadovnikova, Irina A Pakhomova, Elena A Kalabina, Alexander V Lobanov, Elvira R Shaykhutdinova, Alina M Ismailova, Arkady N Murashev
INTRODUCTION: It is important that the method of anesthesia of mice does not considerably alter the animal's physiological and metabolic status before terminal blood sampling taken in order to analyze clinical pathology parameters. METHODS: Hematology, hemostasis, and clinical chemistry parameters were compared in male and female BALB/c mice exposed to either tiletamine-zolazepam-xylazine (TZX) anesthesia or euthanasia in carbon dioxide (CO2) chamber to reveal an alternative method of anesthesia vs...
October 20, 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27693706/human-umbilical-cord-derived-mesenchymal-stem-cells-in-acute-liver-injury-hepatoprotective-efficacy-subchronic-toxicity-tumorigenicity-and-biodistribution
#11
Jun-Won Yun, Jae Hun Ahn, Euna Kwon, Seung-Hyun Kim, Hanna Kim, Ja-June Jang, Woo Ho Kim, Ji Hyang Kim, Su-Youne Han, Jin Tac Kim, Jong-Hoon Kim, Wookhwan Kim, Seung-Yup Ku, Byung-Rok Do, Byeong-Cheol Kang
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) therapy might be an alternative to liver transplantation for acute or chronic liver injury. The aim of this study was to evaluate the efficacy of human UC-MSCs on carbon tetrachloride (CCl4)-induced acute liver injury. In addition, its toxicity, tumorigenicity, and biodistribution were determined. Significant hepatoprotective effects of hUC-MSCs with decreased levels of hepatocellular necrosis and lobular neutrophilic infiltration were found. Regarding the safety of hUC-MSCs, no serious hUC-MSCs-related changes (body weight, food/water consumption, clinical symptom, urinalysis, hematology, clinical chemistry, organ weight, and histopathology) were observed in a 13-week subchronic toxicity study...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27686251/evaluation-of-injectable-robenacoxib-for-the-treatment-of-post-operative-pain-in-cats-results-of-a-randomized-masked-placebo-controlled-clinical-trial
#12
Stephen King, Elizabeth S Roberts, Jonathan N King
BACKGROUND: Few pharmaceuticals are registered in cats for the management of post-operative pain and inflammation. The objective of this study was to assess the field efficacy and safety of an injectable formulation of the nonsteroidal anti-inflammatory drug robenacoxib in cats undergoing surgery. The study was a multi-center, prospective, randomized, masked, parallel-group, placebo-controlled clinical trial. A total of 349 cats were enrolled and underwent surgery comprising forelimb onychectomy, as an example of orthopedic surgery, plus either ovariohysterectomy or castration...
September 29, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27651683/hematology-and-serum-biochemistry-of-indian-spectacled-cobra-naja-naja-and-indian-rat-snake-ptyas-mucosa
#13
Sanath Krishna Muliya, Mudraje Narayana Bhat
AIM: To study the hematology and serum biochemistry parameters of Indian spectacled cobra (Naja naja) and Indian rat snake (Ptyas mucosa) and to evaluate the differences in the same between captive and wild populations. MATERIALS AND METHODS: Animals were categorized into four groups, viz., wild Indian spectacled cobra (n=10), wild Indian rat snakes (n=10), captive Indian spectacled cobra (n=10), and captive Indian rat snake (n=10). The snakes were restrained with restraint tubes, and 2 ml of blood was collected from either heart or ventral coccygeal vein...
August 2016: Veterinary World
https://www.readbyqxmd.com/read/27634062/4-week-repeated-dose-oral-toxicity-study-of-n-ethyl-2-pyrrolidone-in-sprague-dawley-rats
#14
A M Saillenfait, F Marquet, J P Sabaté, D Ndiaye, A M Lambert-Xolin
The solvent N-ethyl-2-pyrrolidone (NEP) was evaluated in a 4-week repeated dose study in rats. NEP diluted in distilled water was orally administered by gavage to male and female Sprague-Dawley rats at doses of 0 (vehicle control), 5, 50, and 250 mg/kg/day for 28 consecutive days. Transient decreases in the body weight and in the body weight gain of the males was observed during the first days of treatment at the 50 and 250 mg/kg/day doses. There was a marked increase in urine volume at the beginning of treatment in males and female rats at doses of 50 and 250 mg/kg/day...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27612832/biocompatible-lutein-polymer-lipid-nanocapsules-acute-and-subacute-toxicity-and-bioavailability-in-mice
#15
Arunkumar Ranganathan, Ravi Hindupur, Baskaran Vallikannan
Lutein-poly-(lactic-co-glycolic acid) (PLGA)-phospholipid (PL) nanocapsules were prepared (henceforth referred as lutein nanocapsules) and studied for acute, subacute oral toxicity and bioavailability of lutein in mice. Prior to examining the safety of lutein nanocapsules, particle size, zeta potential, surface morphology and interaction between lutein, PLGA and PL were studied. In acute study, mice were gavaged with a single dose of lutein nanocapsules at 0.1, 1, 10 and 100mg/kg body weight (BW) and examined for 2weeks, while in subacute study, daily mice were gavaged with a dose of 1 and 10mg/kg BW for 4weeks...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27604182/measurement-of-the-hematocrit-using-paper-based-microfluidic-devices
#16
Samuel B Berry, Syrena C Fernandes, Anjali Rajaratnam, Nicholas S DeChiara, Charles R Mace
The quantification of blood cells provides critical information about a patient's health status. Sophisticated analytical equipment, such as hematology analyzers, have been developed to perform these measurements, but limited-resource settings often lack the infrastructure required to purchase, operate, and maintain instrumentation. To address these practical challenges, paper-based microfluidic devices have emerged as a platform to develop diagnostic assays specifically for use at the point-of-care. To date, paper-based microfluidic devices have been used broadly in diagnostic assays that apply immunoassay, clinical chemistry, and electrochemistry techniques...
October 7, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27589840/hematologic-and-serum-biochemical-changes-associated-with-devil-facial-tumor-disease-in-tasmanian-devils
#17
Sarah Peck, Ross Corkrey, Rodrigo Hamede, Menna Jones, Paul Canfield
BACKGROUND: Devil Facial Tumor Disease (DFTD) is an infectious tumor causing significant population declines in wild Tasmanian Devils. While clinical assessment and pathology have been well reported for DFTD, there is a lack of information on hematologic and biochemical alterations associated with DFTD. OBJECTIVES: The purpose of the study was to determine hematologic and serum biochemical variation in healthy, wounded, and DFTD-affected Tasmanian Devils. METHODS: Blood samples were collected from wild Tasmanian Devils at 5 sites in Tasmania...
September 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27544835/sleep-disordered-breathing-and-nocturnal-hypoxemia-in-young-adults-with-sickle-cell-disease
#18
P L Whitesell, O Owoyemi, P Oneal, M Nouraie, E S Klings, A Rock, T A Mellman, T Berihun, J Lavella, R E Taylor, S P Perrine
Sleep-disordered breathing (SDB) is reported in up to 69% of adolescents and children with sickle cell disease (SCD) [1], but data regarding the prevalence of SDB in adults with SCD are limited. In order to obtain a preliminary assessment of the frequency and degree of sleep-related hypoxemia and potential associations with cardiovascular function in adults with SCD, we conducted overnight sleep studies, 6-min walk tests, echocardiograms, and hematologic and chemistry panels, calculated the Pittsburgh sleep quality index (PSQI), and conducted fatigue- and health-related quality-of-life measurement in 20 young adults with SCD visiting a sickle cell clinic for routine care...
June 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27501060/efficacy-and-safety-of-bunium-persicum-boiss-to-inactivate-protoscoleces-during-hydatid-cyst-operations
#19
Hossein Mahmoudvand, Razieh Tavakoli Oliaei, Seyed Reza Mirbadie, Farnaz Kheirandish, Amir Tavakoli Kareshk, Behrouz Ezatpour, Hormoz Mahmoudvand
BACKGROUND: Current scolicidal agents, which have been used for inactivation of protoscoleces during surgical procedures, are associated with adverse side effects including sclerosing cholangitis. This investigation aimed to evaluate the scolicidal effects of Bunium persicum (Boiss) essential oil against protoscoleces of hydatid cysts and also its toxicity in a mice model. METHODS: Protoscoleces were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (3...
August 8, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27494223/prevalence-and-implications-of-abnormal-laboratory-results-in-patients-in-the-terminal-phase-of-life
#20
Anniek D Masman, Dick Tibboel, Frans P M Baar, Monique van Dijk, Ron A A Mathot, Teun van Gelder
BACKGROUND: Pathophysiological changes at the end of life may affect pharmacokinetics of drugs. However, caregivers typically do not extensively monitor patients' laboratory parameters at the end of life. OBJECTIVE: Our aim was to describe laboratory parameters of hospice patients in the week before death. METHODS: A cohort study was conducted on available laboratory results in the week before death, including clinical chemistry and hematology tests...
August 2016: Journal of Palliative Medicine
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