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Asthma, spirometry in children

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https://www.readbyqxmd.com/read/27888986/relationship-between-birth-weight-maternal-smoking-during-pregnancy-and-childhood-and-adolescent-lung-function-a-path-analysis
#1
Pallavi Balte, Wilfried Karmaus, Graham Roberts, Ramesh Kurukulaaratchy, Frances Mitchell, Hasan Arshad
BACKGROUND: Low birth weight and gestational maternal smoking have been linked with reduced lung function in children in many cross sectional studies. However, these associations have not yet been assessed with repeated measurements of lung function. Our aim was to investigate the effects of birth weight, gestational age, and gestational maternal smoking on lung function in children at age 10 and 18 years. METHODS: In the Isle of Wight birth cohort spirometry was performed at age 10 and 18 years...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27834336/evaluation-of-symptoms-spirometry-in-children-treated-for-asthma
#2
Shobi Anandi, Milind S Tullu, Keya Lahiri
BACKGROUND & OBJECTIVES: Spirometry plays an important role in the assessment and long term monitoring of patients with asthma. Difficulty in performing spirometry in children has resulted in a paucity of Indian studies using spirometry regularly for research in the paediatric population. This study was undertaken to assess the clinical improvement and changes in spirometric measurements with treatment in children with newly diagnosed asthma and to compare the changes in the symptom score and spirometric measurements...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27825992/prevalence-determinants-and-clinical-correlates-of-vitamin-d-deficiency-in-adults-with-inhaled-corticosteroid-treated-asthma-in-london-uk
#3
REVIEW
David A Jolliffe, Kate Kilpin, Beverley D MacLaughlin, Claire L Greiller, Richard L Hooper, Neil C Barnes, Peter M Timms, Raj K Rajakulasingam, Angshu Bhowmik, Aklak B Choudhury, David E Simcock, Elina Hyppönen, Christopher J Corrigan, Robert T Walton, Christopher J Griffiths, Adrian R Martineau
Vitamin D deficiency is common in children with asthma, and it associates with poor asthma control, reduced forced expiratory volume in one second (FEV1) and increased requirement for inhaled corticosteroids (ICS). Cross-sectional studies investigating the prevalence, determinants and clinical correlates of vitamin D deficiency in adults with asthma are lacking. We conducted a multi-centre cross-sectional study in 297 adults with a medical record diagnosis of ICS-treated asthma living in London, UK. Details of potential environmental determinants of vitamin D status, asthma control and medication use were collected by questionnaire; blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction, and participants underwent measurement of weight, height and fractional exhaled nitric oxide concentration (FeNO), spirometry and sputum induction for determination of lower airway eosinophil counts (n=35 sub-group)...
November 5, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27825614/impulse-oscillometry-in-the-assessment-of-asthmatic-children-and-adolescents-from-a-narrative-to-a-systematic-review
#4
REVIEW
Karoliny Dos Santos, Lílian L Fausto, Paulo A M Camargos, Maicon R Kviecinski, Jane da Silva
Diagnosis and management of asthma often relies mostly on symptoms because spirometry is not always reliable in some age groups, such as preschoolers. It is unclear whether impulse oscillometry (IOS) can supplement or replace spirometry. Available reports suggest that IOS has been applied with success in asthmatic children and adolescents to assess exacerbations, level of control, severity and response to treatment in the short and long term. Very few studies using adequate sample sizes and methods have been performed comparing the accuracy of IOS to spirometry for the diagnosis of asthma...
September 28, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27825189/exhaled-nitric-oxide-levels-to-guide-treatment-for-children-with-asthma
#5
REVIEW
Helen L Petsky, Kayleigh M Kew, Anne B Chang
BACKGROUND: Asthma guidelines aim to guide health practitioners to optimise treatment for patients to minimise symptoms, improve or maintain good lung function, and prevent acute exacerbations. The principle of asthma guidelines is based on a step-up or step-down regimen of asthma medications to maximise health using minimum doses. Fractional exhaled nitric oxide (FeNO) is a marker of eosinophilic inflammation and tailoring asthma medications in accordance to airway eosinophilic levels may improve asthma outcomes such as indices of control or reduce exacerbations, or both...
November 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27822106/the-danish-national-database-for-asthma
#6
REVIEW
Vibeke Backer, Jesper Lykkegaard, Uffe Bodtger, Lone Agertoft, Lene Korshoej, Elvira Vaclavik Braüner
AIM OF THE DATABASE: Asthma is the most prevalent chronic disease in children, adolescents, and young adults. In Denmark (with a population of 5.6 million citizens), >400,000 persons are prescribed antiasthmatic medication annually. However, undiagnosed cases, dubious diagnoses, and poor asthma management are probably common. The Danish National Database for Asthma (DNDA) was established in 2015. The aim of the DNDA was to collect the data on all patients treated for asthma in Denmark and to monitor asthma occurrence, the quality of diagnosis, and management...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27803176/examining-profiles-of-family-functioning-in-pediatric-asthma-longitudinal-associations-with-child-adjustment-and-asthma-severity
#7
Nour Al Ghriwati, Marcia A Winter, Robin S Everhart
OBJECTIVE : Identify profiles of functioning in families of children with asthma and examine whether profile membership predicts subsequent child mental and physical well-being. METHODS : Primary caregivers and children (N = 1,030) from the Childhood Asthma Management Program completed questionnaires assessing family functioning and child adaptation at five time points. Asthma severity was also assessed via spirometry. RESULTS : Latent profile analyses identified a four-profile solution as best fitting the data: cohesive, permissive, controlling/disengaged, and controlling/enmeshed families...
November 1, 2016: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/27792747/nasal-airflow-measured-by-rhinomanometry-correlates-with-feno-in-children-with-asthma
#8
I-Chen Chen, Yu-Tsai Lin, Jong-Hau Hsu, Yi-Ching Liu, Jiunn-Ren Wu, Zen-Kong Dai
BACKGROUND: Rhinitis and asthma share similar immunopathological features. Rhinomanometry is an important test used to assess nasal function and spirometry is an important tool used in asthmatic children. The degree to which the readouts of these tests are correlated has yet to be established. We sought to clarify the relationship between rhinomanometry measurements, fractional exhaled nitric oxide (FeNO), and spirometric measurements in asthmatic children. METHODS: Patients' inclusion criteria: age between 5 and 18 years, history of asthma with nasal symptoms, and no anatomical deformities...
2016: PloS One
https://www.readbyqxmd.com/read/27787950/validation-of-the-pediatric-sleep-questionnaire-in-children-with-asthma
#9
Zarmina Ehsan, Carolyn M Kercsmar, Jennifer Collins, Narong Simakajornboon
OBJECTIVE: The prevalence of obstructive sleep apnea (OSA) is higher in children with poorly controlled asthma. We aimed to determine the validity of the Pediatric Sleep Questionnaire (PSQ) to screen for OSA in children with asthma. METHODS: This retrospective review encompassed sleep studies and medical records of asthmatic children evaluated in the sleep center at CCHMC over 13 years. Measures of validity were calculated using various cut-off values for obstructive apnea-hypopnea index (OI; >1, >2, >5) and PSQ scores (>0...
October 27, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27763622/measurement-characteristics-of-the-childhood-asthma-control-test-and-a-shortened-child-only-version
#10
Christian Bime, Joe K Gerald, Christine Y Wei, Janet T Holbrook, William G Teague, Robert A Wise, Lynn B Gerald
The childhood Asthma-Control Test (C-ACT) is validated for assessing asthma control in paediatric asthma. Among children aged 4-11 years, the C-ACT requires the simultaneous presence of both parent and child. There is an unmet need for a tool that can be used to assess asthma control in children when parents or caregivers are not present such as in the school setting. We assessed the psychometric properties and estimated the minimally important difference (MID) of the C-ACT and a modified version, comprising only the child responses (C-ACTc)...
October 20, 2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/27756492/repercussions-of-preterm-birth-on-symptoms-of-asthma-allergic-diseases-and-pulmonary-function-6-14-years-later
#11
C Gonçalves, G Wandalsen, F Lanza, A L Goulart, D Solé, A Dos Santos
BACKGROUND: Prevalence of allergic diseases and impaired pulmonary function may be high in children born prematurely. This study aimed to assess pulmonary function and prevalence of asthma, atopic diseases and allergic sensitisation in these patients. METHODS: A cross-sectional study was conducted with children aged 6-14 years who were born prematurely with birth weight <2000g from January 2008 to May 2011. Exclusion criteria were: major malformations, or acute respiratory disorders...
October 15, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27753690/bronchiectasis-and-other-chronic-lung-diseases-in-adolescents-living-with-hiv
#12
Engi F Attia, Robert F Miller, Rashida A Ferrand
PURPOSE OF REVIEW: The incidence of pulmonary infections has declined dramatically with improved access to antiretroviral therapy (ART) and cotrimoxazole prophylaxis, but chronic lung disease (CLD) is an increasingly recognized but poorly understood complication in adolescents with perinatally acquired HIV. RECENT FINDINGS: There is a high prevalence of chronic respiratory symptoms, abnormal spirometry and chest radiographic abnormalities among HIV-infected adolescents in sub-Saharan Africa, wherein 90% of the world's HIV-infected children live...
October 7, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27749682/dimensions-of-socioeconomic-status-and-childhood-asthma-outcomes-evidence-for-distinct-behavioral-and-biological-associations
#13
Edith Chen, Madeleine U Shalowitz, Rachel E Story, Katherine B Ehrlich, Cynthia S Levine, Robin Hayen, Adam K K Leigh, Gregory E Miller
OBJECTIVES: The objective of this study was to investigate 2 key dimensions of socioeconomic status (SES)-prestige and resources-and their associations with immune, behavioral, and clinical outcomes in childhood asthma. METHODS: Children ages 9 to 17 years with a physician's diagnosis of asthma (N = 150), and one of their parents participated in this study. Children and parents completed interviews and questionnaires about SES (prestige = parent education; resources = family assets), environmental exposures, and clinical asthma measures...
November 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27742871/assessing-bronchodilator-response-in-preschool-children-using-spirometry
#14
Luciano E Busi, Sebastián Restuccia, Ricardo Tourres, Peter D Sly
BACKGROUND: Measuring lung function, including bronchodilator response (BDR), is an integral part of asthma management in older children. While spirometry is possible in preschool-aged children, the question remains whether measuring BDR aids in asthma diagnosis in this age group. METHODS: 431 healthy children and 289 children with asthma, aged 3-5 years, were recruited from kindergartens and the pulmonology clinic in Trelew, Argentina. Spirometry was performed at visit 1 and repeated after 15 min, with children randomised to placebo or salbutamol (400 µg)...
October 14, 2016: Thorax
https://www.readbyqxmd.com/read/27723955/halotherapy-as-asthma-treatment-in-children-a-randomized-controlled-prospective-pilot-study
#15
Ronen Bar-Yoseph, Nir Kugelman, Galit Livnat, Michal Gur, Fahed Hakim, Vered Nir, Lea Bentur
BACKGROUND AND OBJECTIVES: Asthma is a chronic inflammatory disorder requiring intermittent or continuous anti-inflammatory therapy. Patients often turn to alternative treatments as complements or replacements to conventional treatments. We aimed to evaluate the effect of salt room chambers (halotherapy) on bronchial hyper-responsiveness (BHR), fractional exhaled nitric oxide (FeNO), and quality of life in children with asthma. PATIENTS AND METHODS: Children aged 5-13 years with a clinical diagnosis of mild asthma not receiving anti-inflammatory therapy...
October 10, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27709308/evaluation-of-the-improvement-effect-of-laser-acupuncture-biostimulation-in-asthmatic-children-by-exhaled-inflammatory-biomarker-level-of-nitric-oxide
#16
Ola A Dabbous, Mona M Soliman, Nagwa H Mohamed, Magda Y Elseify, Mai S Elsheikh, Asmaa A A Alsharkawy, Manal M Abd Al Aziz
Variable therapy of asthma is not sufficient yet to achieve good asthma control. Therapy decision requires serial investigations. Low-level laser acupuncture is a suitable non-invasive modality of complementary medicine. The exhaled breath condensate (EBC) is easy and useful to evaluate the efficacy of drugs or novel therapy. This study aimed to evaluate the effectiveness of low-level laser biostimulation of acupuncture points on asthma improvement in children. Forty-eight asthmatic children were subdivided into case (laser) group, which received 12 direct contact low-power laser acupuncture sessions (three sessions/week) on specific traditional Chinese acupuncture points for bronchial asthma, and control asthmatic group, which received sham laser acupuncture on the same acupoints and number of sessions of the case (laser) group...
October 5, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27641483/school-environmental-intervention-to-reduce-particulate-pollutant-exposures-for-children-with-asthma
#17
Iny Jhun, Jonathan M Gaffin, Brent A Coull, Michelle F Huffaker, Carter R Petty, William J Sheehan, Sachin N Baxi, Peggy S Lai, Choong-Min Kang, Jack M Wolfson, Diane R Gold, Petros Koutrakis, Wanda Phipatanakul
BACKGROUND: Home-based interventions to improve indoor air quality have demonstrated benefits for asthma morbidity, yet little is known about the effect of environmental interventions in the school setting. OBJECTIVE: We piloted the feasibility and effectiveness of a classroom-based air cleaner intervention to reduce particulate pollutants in classrooms of children with asthma. METHODS: In this pilot randomized controlled trial, we assessed the effect of air cleaners on indoor air particulate pollutant concentrations in 18 classrooms (9 control, 9 intervention) in 3 urban elementary schools...
September 15, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27638292/allergy-testing-in-children-with-persistent-asthma-comparison-of-four-diagnostic-methods
#18
A Önell, A Whiteman, B Nordlund, F Baldracchini, G Mazzoleni, G Hedlin, H Grönlund, J R Konradsen
BACKGROUND: Multiple allergic sensitizations are common in persistent childhood asthma, and thorough assessment of allergy is crucial for optimal care of these children. Microarray testing offers opportunities for improved sIgE characterization, which has been projected to be useful in the management of multisensitized patients. OBJECTIVE: The aim of this study was to investigate the accuracy and information obtained by two microarray platforms applied on a well-characterized pediatric asthma cohort...
September 17, 2016: Allergy
https://www.readbyqxmd.com/read/27613456/telemedicine-is-as-effective-as-in-person-visits-for-patients-with-asthma
#19
Jay M Portnoy, Morgan Waller, Stephen De Lurgio, Chitra Dinakar
BACKGROUND: Access to asthma specialists is a problem, particularly in rural areas, thus presenting an opportunity for management using telemedicine. OBJECTIVE: To compare asthma outcomes during 6 months in children managed by telemedicine vs in-person visits. METHODS: Children with asthma residing in 2 remote locations were offered the choice of an in-person visit or a telemedicine session at a local clinic. The telemedicine process involved real-time use of a Remote Presence Solution (RPS) equipped with a digital stethoscope, otoscope, and high-resolution camera...
September 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27599947/-identification-of-gaps-in-the-clinical-patient-care-of-asthma-in-spain-results-of-the-optima-gema-survey
#20
V Plaza, P Rodríguez Del Río, F Gómez, A López Viña, J Molina, J A Quintano, S Quirce, R Soler, J R Villa, A Nieto
BACKGROUND: Based on the GEMA 2009 guidelines (Spanish Asthma Management Guidelines), this project identified and assessed the main deficiencies in the implementation of the guidelines and proposed initiatives for improvement. METHODS: The study gathered and evaluated the opinions of a multidisciplinary group of asthma experts (allergists, pulmonologists, pediatricians, and primary care physicians). The first step identified health care aspects of GEMA 2009 that could be improved (Phase I)...
2016: Anales del Sistema Sanitario de Navarra
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