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androgenetic alopecia

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https://www.readbyqxmd.com/read/29146897/gwas-for-male-pattern-baldness-identifies-71-susceptibility-loci-explaining-38-of-the-risk
#1
Nicola Pirastu, Peter K Joshi, Paul S de Vries, Marilyn C Cornelis, Paul M McKeigue, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L Giovannucci, Athina Spiliopoulou, Lude Franke, Kari E North, Peter Kraft, Alanna C Morrison, Tõnu Esko, James F Wilson
Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes that are relevant to the pathology and highlight pathways and functions underlying baldness...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29141068/new-insight-into-the-pathophysiology-of-hair-loss-trigger-a-paradigm-shift-in-the-treatment-approach
#2
Neil S Sadick, Valerie D Callender, Leon H Kircik, Sophia Kogan
<p>Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29139043/early-onset-baldness-and-the-risk-of-aggressive-prostate-cancer-findings-from-a-case-control-study
#3
Nathan P Papa, Robert J MacInnis, Dallas R English, Damien Bolton, Ian D Davis, Nathan Lawrentschuk, Jeremy L Millar, Gianluca Severi, John L Hopper, Graham G Giles
PURPOSE: We aimed to evaluate the associations between androgenetic alopecia at a young age and subsequent development of aggressive prostate cancer (PC). METHODS: Using a case-control design with self-administered questionnaire, we evaluated the association between aggressive PC and very early-onset balding at age 20, and early-onset balding at age 40 years in 1,941 men. Cases were men with high-grade and/or advanced stage cancer and controls were clinic based men who had undergone biopsy and were found to be histologically cancer negative...
November 14, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29122575/identification-of-functional-patterns-of-androgenetic-alopecia-using-transcriptome-profiling-in-distinct-locations-of-hair-follicles
#4
Yong Miao, Qian Qu, Wei Jiang, Xiao-Min Liu, Pan-Li Shi, Zhe-Xiang Fan, Li-Juan Du, Gao-Feng Wang, Xiao-Nan Liu, Zhen-He Guo, Yang Liu, Fang Liu, Ya-Rui Liu, Zhi-Qi Hu
No abstract text is available yet for this article.
November 6, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29118521/a-proposal-of-an-effective-platelet-rich-plasma-protocol-for-the-treatment-of-androgenetic-alopecia
#5
Juan Ferrando, Sandra Cecilia García-García, Ana Cecilia González-de-Cossío, Lola Bou, Esperanza Navarra
Background: Platelet-rich plasma (PRP) has emerged as a promising treatment for androgenetic alopecia (AGA). In spite of the several studies previously reported, to date, a standardized protocol for PRP preparation and application, as well as a standard method for evaluating results has not been established. Aims: The aim of this study is to propose a standardized method for preparation and application of PRP for male AGA (MAGA) and female AGA (FAGA) and assess its safety and efficacy as a co-adjuvant therapy...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29101437/comparison-of-the-efficacy-of-homologous-and-autologous-platelet-rich-plasma-prp-for-treating-androgenic-alopecia
#6
Bilsev Ince, Mehmet Emin Cem Yildirim, Mehmet Dadaci, Mustafa Cihat Avunduk, Nedim Savaci
BACKGROUND: Androgenetic alopecia (AGA), the most common cause of hair loss in both sexes, accounts for 95% of all cases of hair loss. Although the literature has suggested that both nonactivated (n-PRP) and activated autologous (a-PRP) PRP can be used to treat AGA, we did not find any study investigating the use of homologous PRP (h-PRP) for this purpose. Also, to the best of our knowledge, there are no studies comparing the efficacy of h-PRP, a-PRP, or n-PRP on AGA therapy. OBJECTIVES: The aim of this study was to compare the increase in hair density, average number of platelets, complications, preparation, and duration of application in the treatment of AGA using a-PRP, n-PRP, and h-PRP...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29062667/hair-transplantation-in-migraine-headache-patients
#7
Safvet Ors
BACKGROUND: Migraine headache is a primary neurologic disease affecting millions of people worldwide. As a consequence, quality of life is diminished, productivity suffers (through loss of work force), and treatment costs are substantial. The occurrence rate in the general population is quite high, with women accounting for 3 of every 4 cases. METHODS: Between January 2011 and May 2012, a total of 221 patients received hair transplants. Another 590 patients underwent hair transplantation between June 2012 and December 2016...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29055953/an-open-label-randomized-multicenter-study-assessing-the-noninferiority-of-a-caffeine-based-topical-liquid-0-2-versus-minoxidil-5-solution-in-male-androgenetic-alopecia
#8
Rachita Dhurat, Jill Chitallia, Theodor W May, Ammani M Jayaraaman, Jithendriya Madhukara, Subbu Anandan, Pradyumna Vaidya, Adolf Klenk
BACKGROUND: Androgenetic alopecia is a condition with a high prevalence worldwide and affects both males and females. Currently, only 2 approved treatments exist: finasteride (males only) and minoxidil 2 or 5% solution (males and females). METHODS: We conducted a randomized, open-label, multicenter noninferiority study to determine whether a caffeine-based 0.2% topical liquid would be no less effective than minoxidil 5% solution in males (n = 210) with androgenetic alopecia...
October 21, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29055061/preservation-of-stem-cells-in-androgenetic-alopecia
#9
Hend Gamil, Magda Assaf, Manal Elsayed, Khaled Gharib, Mohamed Soliman, Naglaa A Mostafa
Androgenetic alopecia is characterized by progressive, patterned hair loss from the scalp that occurs in both men and women. Suggested that genetically predisposed hair follicles are target for androgen-stimulated follicle miniaturization, with gradual replacement of terminal hairs by vellus hairs. We aimed at evaluating the expression of stem and progenitor cell markers using IHC in scalp biopsies from affected and unaffected areas of patients with AGA. This article is protected by copyright. All rights reserved...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29028377/randomized-trial-of-electrodynamic-microneedle-combined-with-5-minoxidil-topical-solution-for-the-treatment-of-chinese-male-androgenetic-alopecia
#10
Linlin Bao, Lin Gong, Menger Guo, Taoming Liu, Anyu Shi, Haifeng Zong, Xuegang Xu, Hongduo Chen, Xinghua Gao, Yuanhong Li
BACKGROUND: In treating androgenetic alopecia, 5% minoxidil is a commonly used topical drug. By using electrodynamic microneedle at the same time may increase absorption of minoxidil and further stimulate hair growth. OBJECTIVE: A 24-week, randomized, evaluator blinded, comparative study was performed to evaluate the efficacy of treating Chinese male androgenetic alopecia using microneedle combined with 5% minoxidil topical solution. METHODS: Randomized subjects received topical 5% minoxidil (group 1, n = 20), local electrodynamic microneedle treatments (group 2, n = 20), or local electrodynamic microneedle treatments plus topical 5% minoxidil (group 3, n = 20)...
October 13, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29020478/photobiomodulation-therapy-for-androgenetic-alopecia-a-clinician-s-guide-to-home-use-devices-cleared-by-the-federal-drug-administration
#11
Erin M Dodd, Margo A Winter, Maria K Hordinsky, Neil S Sadick, Ronda S Farah
The market for home-use photobiomodulation devices to treat androgenetic alopecia has rapidly expanded, and the FDA has recently cleared many devices for this purpose. Patients increasingly seek dermatologists' advice regarding the safety and efficacy of these hair loss treatments. The purpose of this guide was threefold: 1) to identify all home-use photobiomodulation therapy devices with FDA-clearance for treatment of androgenetic alopecia; 2) to review device design, features and existing clinical evidence; and 3) to discuss practical considerations of photobiomodulation therapy, including patient suitability, treatment goals, safety, and device selection...
October 11, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28966516/comprehensive-transcriptome-profiling-of-balding-and-non-balding-scalps-in-trichorhinophalangeal-syndrome-type-i-patient
#12
Yun-Ji Kim, Byulee Yoon, Kyudong Han, Byung Cheol Park
BACKGROUND: Trichorhinophalangeal syndrome (TRPS) patients tend to have alopecia that appears to be androgenetic, and this genetic model might give clues to the pathogenesis of hair loss or hair morphogenesis. OBJECTIVE: This study was conducted to identify additional genetic evidence of TRPS and hair morphogenesis from a TRPS patient. METHODS: From one TRPS type I patient, we extracted RNA and profiled whole transcriptome in non-balding and balding scalp areas using high-throughput RNA sequencing...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28932074/mesotherapy-with-dutasteride-in-the-treatment-of-androgenetic-alopecia
#13
David Saceda-Corralo, Ana Rita Rodrigues-Barata, Sergio Vañó-Galván, Pedro Jaén-Olasolo
No abstract text is available yet for this article.
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28932068/familial-cicatricial-alopecia-report-of-familial-frontal-fibrosing-alopecia-and-fibrosing-alopecia-in-a-pattern-distribution
#14
Dandara Meurer Missio, Maria Fernanda Reis Gavazzoni Dias, Ralph Michel Trüeb
Frontal fibrosing alopecia (FFA) and fibrosing alopecia in a pattern distribution (FAPD) as originally reported by Kossard in 1994 and by Zinkernagel and Trüeb in 2000, respectively, represent two distinct patterns of cicatricial pattern hair loss. Both share a patterned distribution and histological evidence of a lichenoid follicular inflammation with fibrosis. FFA is characterized by a marginal alopecia along the frontotemporal hairline, and FAPD by a progressive alopecia of the centroparietal scalp. Since the original reports, evidence has accumulated that there exists considerable clinical overlap among FFA, FAPD, and lichen planopilaris, with coexistence of features of the three conditions within the same individual...
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28932067/extensive-donor-site-keloids-in-follicular-unit-extraction-hair-transplantation
#15
Shimona Garg, Anand Kumar, Ankita Tuknayat, Gurvinder Pal Thami
Hair transplantation, a generally regarded as a safe surgical modality for the treatment of androgenetic alopecia, is not without its potential risks and complications. A case of an extensive keloid formation at donor site following follicular unit extraction is discussed. Hair transplant surgeons should be aware of this significant potential complication, especially in patients having previous keloidal tendencies to avoid such disastrous outcomes.
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28925637/hair-loss-common-causes-and-treatment
#16
T Grant Phillips, W Paul Slomiany, Robert Allison
Hair loss is often distressing and can have a significant effect on the patient's quality of life. Patients may present to their family physician first with diffuse or patchy hair loss. Scarring alopecia is best evaluated by a dermatologist. Nonscarring alopecias can be readily diagnosed and treated in the family physician's office. Androgenetic alopecia can be diagnosed clinically and treated with minoxidil. Alopecia areata is diagnosed by typical patches of hair loss and is self-limited. Tinea capitis causes patches of alopecia that may be erythematous and scaly and must be treated systemically...
September 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28912032/androgens-and-androgen-receptor-action-in-skin-and-hair-follicles
#17
REVIEW
Julieta María Ceruti, Gustavo José Leirós, María Eugenia Balañá
Beyond sexual functions, androgens exert their action in skin physiology and pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we analyze recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of their molecular mechanisms in androgenetic alopecia (AGA)...
September 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28905175/the-promotion-of-hair-regrowth-by-topical-application-of-a-perilla-frutescens-extract-through-increased-cell-viability-and-antagonism-of-testosterone-and-dihydrotestosterone
#18
Jing-Jie Li, Zheng Li, Li-Juan Gu, Kang-Ju Choi, Dong-Seon Kim, Ho-Kyoung Kim, Chang-Keun Sung
This study investigated the potential hair regrowth effects associated with a plant extract of Perilla frutescens, which was selected due to its putative hair regrowth activity. Extracts were prepared from dried P. frutescens suspended in distilled water, where the resultant aqueous suspension was fractionated sequentially using hexane, ethyl acetate, n-butanol, and distilled water. We observed that the n-butanol fraction resulted in the highest hair regrowth activity. The n-butanol soluble fraction of P. frutescens extract (BFPE) was further separated using AB-8 macroporous resin and silica gel chromatography to obtain rosmarinic acid (RA), which demonstrated effective hair growth regeneration potential...
September 13, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28856798/digit-ratio-2d-4d-is-a-possible-indicator-for-androgenetic-alopecia-in-males
#19
Mehmet Unal
BACKGROUND: Androgenetic alopecia (AGA) is the most common hair loss. The 2D:4D digit ratio refers to the ratio of the length of the second finger to that of the fourth finger and is thought as a marker of prenatal androgen exposure. OBJECTIVES: There are many studies which have examined the relationship between 2D:4D ratio and some other diseases. In this study, we evaluated the relationship between digit ratio 2D:4D and AGA. METHODS: The study group was composed of a male with AGA and healthy controls...
August 29, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28839391/adult-onset-hair-casts-nits-which-do-not-itch
#20
Archana Jagdish Lokhande, Amita Sutaria
Hair casts (HCs) are thin, elongated, firm, whitish cylindrical concretions which ensheath the hair shaft and can be easily dislodge. They are of two different types: peripilar and parakeratotic keratin cast. Due to its clinical resemblance to pediculosis capitis, the entity is also known as pseudonits. Al though not unusual, false diagnoses are common, and thus, it is very important to correctly differentiate it from other similar conditions. We report here a case of HC involving scalp as well as body hair in association with androgenetic alopecia in a 22-year-old male patient...
April 2017: International Journal of Trichology
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