keyword
https://read.qxmd.com/read/38493246/analysis-of-the-finasteride-treatment-and-its-withdrawal-in-the-rat-hypothalamus-and-hippocampus-at-whole-transcriptome-level
#1
JOURNAL ARTICLE
S Giatti, L Cioffi, S Diviccaro, R Piazza, R C Melcangi
PURPOSE: As reported in patients treated for androgenetic alopecia with finasteride (i.e., a blocker of the enzyme 5 alpha-reductase) and in an animal model, side effects affecting sexual, psychiatric, neurological, and physical domains, may occur during the treatment and persist with drug suspension. The etiopathogenesis of these side effects has been poorly explored. Therefore, we performed a genome-wide analysis of finasteride effects in the brain of adult male rat. METHODS: Animals were treated (i...
March 17, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38478937/androgenetic-alopecia-what-works
#2
EDITORIAL
Jeff Donovan
No abstract text is available yet for this article.
January 2024: Cutis; Cutaneous Medicine for the Practitioner
https://read.qxmd.com/read/38473791/the-biology-and-genomics-of-human-hair-follicles-a-focus-on-androgenetic-alopecia
#3
REVIEW
Raquel Cuevas-Diaz Duran, Emmanuel Martinez-Ledesma, Melissa Garcia-Garcia, Denisse Bajo Gauzin, Andrea Sarro-Ramírez, Carolina Gonzalez-Carrillo, Denise Rodríguez-Sardin, Alejandro Fuentes, Alejandro Cardenas-Lopez
Androgenetic alopecia is a highly prevalent condition mainly affecting men. This complex trait is related to aging and genetics; however, multiple other factors, for example, lifestyle, are also involved. Despite its prevalence, the underlying biology of androgenetic alopecia remains elusive, and thus advances in its treatment have been hindered. Herein, we review the functional anatomy of hair follicles and the cell signaling events that play a role in follicle cycling. We also discuss the pathology of androgenetic alopecia and the known molecular mechanisms underlying this condition...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38465061/comparison-of-efficacy-of-platelet-rich-plasma-with-and-without-topical-minoxidil-for-hair-growth-in-patients-with-androgenetic-alopecia-a-prospective-study
#4
JOURNAL ARTICLE
Soorumsetty Ruthvik, Rubin S John, Melvin George, Santhosh P Kumar, Murugesan Krishnan
Introduction Androgenetic pattern of alopecia is a common problem occurring in men, which mostly arises from their younger age. There are many therapies advocated in the literature for hair loss reduction, and one of them is platelet-rich plasma (PRP) therapy. This study aimed to assess the efficacy of combined PRP therapy with topical minoxidil over PRP as monotherapy in hair loss reduction and regeneration of new hair. Materials and methods The study was conducted at our institute in the Department of Oral and Maxillofacial Surgery at Saveetha Dental College and Hospital...
February 2024: Curēus
https://read.qxmd.com/read/38463254/study-on-the-efficacy-and-potential-mechanism-of-topical-shen-bai-hair-growing-decoction-against-androgenetic-alopecia-based-on-ultrahigh-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-and-rna-seq
#5
JOURNAL ARTICLE
Mingxi Li, Xiujun Zhang, Yan Wang, Beibei Xiang, Zhaoyi Liu, Wenwen Zhang, Xuanming Liu, Ruoxi Guo
Androgenetic alopecia (AGA) is a major problem that can happen to people of all ages, leading to psychological problems, such as anxiety and depression. Topical Shen Bai hair growing decoction (TSBHGD) is based on the pathogenesis of AGA, combined with Traditional Chinese Medicine theory, improved by the Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital according to its clinical treatment experience. This study was designed to demonstrate the therapeutic efficacy of TSBHGD against AGA, analyze the chemical components of TSBHGD as well as the skin-retained and blood-retained components in mice after topical administration of TSBHGD, and clarify the mechanism of its therapeutic efficacy...
March 5, 2024: ACS Omega
https://read.qxmd.com/read/38451966/factors-associated-with-early-onset-androgenetic-alopecia-a-scoping-review
#6
JOURNAL ARTICLE
Li-Ping Liu, Mary Adumo Wariboko, Xiao Hu, Zi-Han Wang, Qian Wu, Yu-Mei Li
BACKGROUND: Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding of early-onset AGA may enable earlier intervention in individuals at high risks. This scoping review aims to explore the risk factors and etiology, associated conditions, and adverse effects on wellbeing in early-onset AGA. METHODS: Electronic literature searches were conducted in MEDLINE, EMBASE and CENTRIAL...
2024: PloS One
https://read.qxmd.com/read/38443122/survey-of-dermatology-practitioners-opinions-and-prescribing-habits-of-oral-minoxidil-for-the-treatment-of-androgenetic-alopecia
#7
JOURNAL ARTICLE
Eric Sanfilippo, Adam Friedman
BACKGROUND: Utilization of low-dose oral minoxidil has increased in recent years in association with several clinical studies that have shown its efficacy in treating androgenetic alopecia (AGA).  Objective: To assess dermatology providers' attitudes and recommendation behaviors of oral minoxidil for the treatment of AGA. METHODS: An online survey gauging the professional opinions, prescribing behaviors, and use of oral minoxidil was sent using the Orlando Dermatology Aesthetic and Clinical Conference email listserv which included multiple levels of dermatology practitioners including MD/DOs, NPs, and PAs across the United States...
March 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38443118/examining-the-uncertainties-surrounding-exosome-therapy-in-androgenetic-alopecia-a-call-for-evidence-based-practice
#8
JOURNAL ARTICLE
Michael G Buontempo, Lina Alhanshali, Mirena Ide, Jerry Shapiro, Kristen Lo Sicco
Hair loss, a pervasive and often distressing condition, affects a substantial number of individuals globally. Although conventional treatments such as hair transplantation, topicals, oral medications, and injectables exist, they have limitations, including the necessity for repeated treatments, potential adverse effects, and cost barriers. Exosome therapy, an innovative and burgeoning option within regenerative medicine, offers a novel approach to hair loss treatment. Exosomes are small vesicles that are produced from the membranes of late-endosomes and secreted by cells, playing a crucial role in intercellular communication...
March 1, 2024: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/38440324/bioinspired-engineering-adsc-nanovesicles-thermosensitive-hydrogel-enhance-autophagy-of-dermal-papilla-cells-for-androgenetic-alopecia-treatment
#9
JOURNAL ARTICLE
Jiachao Xiong, Zhixiao Liu, Lingling Jia, Yulin Sun, Rong Guo, Tingting Xi, Zihan Li, Minjuan Wu, Hua Jiang, Yufei Li
Androgenic alopecia (AGA) is a highly prevalent form of non-scarring alopecia but lacks effective treatments. Stem cell exosomes have similar repair effects to stem cells, suffer from the drawbacks of high cost and low yield yet. Cell-derived nanovesicles acquired through mechanical extrusion exhibit favorable biomimetic properties similar to exosomes, enabling them to efficiently encapsulate substantial quantities of therapeutic proteins. In this study, we observed that JAM-A, an adhesion protein, resulted in a significantly increased the adhesion and resilience of dermal papilla cells to form snap structures against damage caused by dihydrotestosterone and macrophages, thereby facilitating the process of hair regrowth in cases of AGA...
June 2024: Bioactive Materials
https://read.qxmd.com/read/38429917/higher-percentage-of-cd34-stem-cells-and-elevated-efficacy-in-androgenetic-alopecia-treatment-observed-in-cgf-prepared-from-640%C3%A2-nm-laser-pretreated-blood-a-preliminary-study
#10
JOURNAL ARTICLE
Jin Gao, Qin Xiao, Yongzhou Lu, Jing Guo, Dongdong Luan, Chuanlong Jia, Qiannan Xu, Nan Xu
BACKGROUND: Concentrated growth factor (CGF) injection has proven effective in treating androgenetic alopecia (AGA). The primary mechanism of CGF in treating AGA is thought to be the CD34+ stem cells and platelets-associated growth factors being injected into the scalp. CGF efficacy in treating AGA may rely on the activation level of these stem cells and platelets. The 640 nm laser is a United States Food and Drug Administration approved AGA treatment that activates follicle stem cells...
March 1, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38427446/the-challenge-of-regrowing-hair-with-lasers-in-androgenetic-alopecia
#11
JOURNAL ARTICLE
Margit L W Juhasz, Ella Csuka, Colin Kincaid, Natasha Atanaskova Mesinkovska
No abstract text is available yet for this article.
March 1, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/38417724/synergistic-treatment-of-androgenetic-alopecia-with-follicular-co-delivery-of-minoxidil-and-cedrol-in-metal-organic-frameworks-stabilized-by-covalently-cross-linked-cyclodextrins
#12
JOURNAL ARTICLE
Zehui He, Yongtai Zhang, Zhenda Liu, Teng Guo, Xinyi Ai, Yuanzhi He, Xiaolin Hou, Nianping Feng
Androgenetic alopecia seriously affects the physical and mental health of patients. The main clinical therapeutic agent, minoxidil tincture, is challenged by solvent irritation and dose-dependent side effects. Our recent work has identified a biosafety natural product, cedrol, that is synergistic in combination with minoxidil, thereby improving medication safety by substantially reducing the clinical dose of minoxidil. In addition, ccross-linked CD-MOF were designed as carriers for hair follicle delivery, and γ-CD in the carriers was cross-linked by diphenyl carbonate with covalent bonds to protect the CD-MOF from rapid disintegration in an aqueous environment...
February 26, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38398550/-%C3%AE-nicotinamide-mononucleotide-promotes-cell-proliferation-and-hair-growth-by-reducing-oxidative-stress
#13
JOURNAL ARTICLE
Chuntao Xu, Jiawei Dai, Hongxia Ai, Weian Du, Hongbing Ji
β-Nicotinamide mononucleotide (NMN) has shown promising effects on intestinal health, and it is extensively applied as an anti-aging and Alzheimer's disease therapeutic, due to its medicinal properties. The effects of NMN on the growth of mouse hair were observed after hair removal. The results indicated that NMN can reverse the state of hair follicle atrophy, hair thinning, and hair sparsity induced by dihydrotestosterone (DHT), compared to that of minoxidil. In addition, the action mechanisms of NMN promoting hair growth in cultured human dermal papilla cells (HDPCs) treated with DHT were investigated in detail...
February 8, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38390155/serum-lipidomic-changes-and-sex-differences-in-androgenetic-alopecia
#14
JOURNAL ARTICLE
Shuqin Wang, Mei Li, Shichun Qin, Rui Wang, Liping Dong, Sheng Wang, Fengli Xiao
BACKGROUND: Androgenetic alopecia (AGA) is the most common form of hair loss. Studies have suggested a potential link to metabolic disorders, but with conflicting results. To elucidate the lipidomics profile and sex-specific variations in AGA, while exploring correlation between AGA and metabolic syndrome (MetS). METHODS: The AGA patients (n = 83) and healthy controls (n = 84) were collected in the study. The lipid profiles were analyzed using ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS)...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38381230/the-role-of-laser-and-energy-assisted-drug-delivery-in-the-treatment-of-alopecia
#15
REVIEW
Eliza Balazic, Ahava Muskat, Yana Kost, Joel L Cohen, Kseniya Kobets
It has been recently established that laser treatment can be combined with topical or intralesional medications to enhance the delivery of drugs and improve overall results in a variety of different dermatological disorders. The aim of this review is to evaluate the use of laser and energy-assisted drug delivery (LEADD) for the treatment of alopecia with a specific focus on ablative fractional lasers (AFL), non-ablative fractional lasers (NAFL), and radiofrequency microneedling (RFMN). A comprehensive PubMed search was performed in December 2022 for "laser-assisted drug delivery" as well as "laser" and "alopecia...
February 21, 2024: Lasers in Medical Science
https://read.qxmd.com/read/38376087/low-dose-oral-minoxidil-for-alopecia-a-comprehensive-review
#16
JOURNAL ARTICLE
Aditya K Gupta, Mesbah Talukder, Avner Shemer, Bianca Maria Piraccini, Antonella Tosti
Low-dose oral minoxidil (LDOM) has demonstrated a promising safety and efficacy profile in the treatment of various hair disorders, including male androgenetic alopecia (AGA) and female-pattern hair loss (FPHL); however, it lacks FDA approval. The usual LDOM starting dose for male AGA is 1-5 mg/day, depending on physician preference and the patient's condition. For FPHL, it is 0.5-1 mg/day. The maximum dose is generally 5 mg/day. If patients respond well without major side effects, the dose may be gradually increased since the LDOM's efficacy appears to be dose-dependent...
December 2023: Skin Appendage Disorders
https://read.qxmd.com/read/38376068/platelet-rich-plasma-advances-and-controversies-in-hair-restoration-and-skin-rejuvenation
#17
JOURNAL ARTICLE
Arianne Shadi Kourosh, Kathyana P Santiago Mangual, Ronda S Farah, Medha Rao, Maria K Hordinsky, Suleima Arruda, Neil Sadick
BACKGROUND: Platelet-rich plasma (PRP) and its combined therapeutic modalities have catalyzed new possibilities in dermatology; however, limitations in evidence and lack of consensus remain among clinicians regarding optimal composition, protocol, technique, and application. OBJECTIVE: To provide an update and analysis of the evidence for PRP in hair restoration and skin rejuvenation through review of recent available data, highlighting controversies and expert insights to guide future studies, and stimulate discourse and innovations benefitting patients...
February 20, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/38364424/peripilar-sign-in-androgenetic-alopecia-does-it-really-indicate-peripilar-infiltrate
#18
JOURNAL ARTICLE
Dina Abdalla, Manal Bosseila, Mona R E Abdel-Halim, Iman Sany
INTRODUCTION: Peripilar sign (PPS) is a trichoscopic sign that was first described in androgenetic alopecia (AGA) and is thought to reflect the presence of perifollicular infiltrate (PFI) in histopathology. OBJECTIVES: To study PPS in a cohort of patients with AGA and to assess its validity as a sign indicative of PFI. METHODS: One hundred patients with AGA (confirmed by trichoscopic examination) were recruited in this cross-sectional study...
January 1, 2024: Dermatology Practical & Conceptual
https://read.qxmd.com/read/38362691/designing-optimising-and-assessing-a-novel-emulgel-containing-minoxidil-for-controlled-drug-release-incorporating-marine-based-polymers
#19
JOURNAL ARTICLE
Flowerlet Mathew, A Mary Saral
OBJECTIVE: This study aimed to develop an emulgel containing minoxidil as a drug for hair growth promotion in diseases, such as androgenetic alopecia, using gelling agents, such as chitosan and fucoidan. METHODS: In this study, gelling agents were selected for the emulgel formulation. By various evaluation tests and through optimization, the chitosan-fucoidan combination was selected as the gelling agent for the preparation of emulgel using various evaluation parameters...
February 15, 2024: Current Drug Delivery
https://read.qxmd.com/read/38361837/the-psychosocial-burden-of-androgenetic-alopecia-in-saudi-arabia-a-cross-sectional-study
#20
JOURNAL ARTICLE
Mohammed A Almashali, Manar A Alotaibi, Alanoud H Alkhanani, Norah M Al Dera, Muhannad M Alwadany, Abdulelah S Almousa, Asem M Shadid
BACKGROUND: The most prevalent cause of hair loss is androgenetic alopecia. Improved therapeutic modalities may result from knowing how stress affects hair growth, incorporating stress-coping methods into the treatment of hair loss disorders, and developing new pharmacotherapeutic approaches. This study aimed to examine the psychosocial burden of androgenetic alopecia in Saudi Arabia. MATERIALS AND METHODS: A cross-sectional online survey study was conducted among patients with androgenetic alopecia in Saudi Arabia in February 2023...
December 2023: Journal of Family Medicine and Primary Care
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