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androgenetic alopecia

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https://www.readbyqxmd.com/read/29785802/bayesian-measurement-error-driven-hidden-markov-regression-model-for-calibrating-the-effect-of-covariates-on-multistate-outcomes-application-to-androgenetic-alopecia
#1
Amy Ming-Fang Yen, Hsiu-Hsi Chen
Multistate Markov regression models used for quantifying the effect size of state-specific covariates pertaining to the dynamics of multistate outcomes have gained popularity. However, the measurements of multistate outcome are prone to the errors of classification, particularly when a population-based survey/research is involved with proxy measurements of outcome due to cost consideration. Such a misclassification may affect the effect size of relevant covariates such as odds ratio used in the field of epidemiology...
May 21, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29769782/graft-versus-host-disease-presenting-as-fibrosing-alopecia-in-a-pattern-distribution-a-model-for-pathophysiological-understanding-of-cicatricial-pattern-hair-loss
#2
Hudson Dutra Rezende, Maria Fernanda Reis Gavazzoni Dias, Ralph Michel Trüeb
A case of cutaneous graft versus host disease (GvHD) presenting as fibrosing alopecia in a pattern distribution (FAPD) is discussed, possibly providing a mechanistic model for a better understanding of the pathogenic events underlying cicatricial pattern hair loss. The implication of a follicular inflammation and fibrosis associated with patterned hair loss has emerged from several independent studies. Eventually, Zinkernagel and Trüeb reported a peculiar type of cicatricial pattern hair loss with histopathological features consistent with lichen planopilaris (LPP) associated with androgenetic alopecia (AGA)...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29769781/case-report-of-connubial-frontal-fibrosing-alopecia
#3
Ricardo da Silva Libório, Ralph M Trüeb
Since its original report in 1994, frontal fibrosing alopecia has become increasingly common, attracting the attention of the medical community and giving rise to speculations on its etiology, specifically the possibility of environmental factors. Familial cases of frontal fibrosing alopecia point to the possible contribution of hereditary factors maybe related to androgenetic alopecia. We report thefirst case of connubial frontal fibrosing alopecia in a genetically unrelated couple pointing to the possibility of a common environmental exposure in the etiology of the condition...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29765966/further-clinical-evidence-for-the-effect-of-igf-1-on-hair-growth-and-alopecia
#4
Ralph M Trüeb
Observations on the Laron syndrome originally offered the opportunity to explore the effect of insulin-like growth factor 1 (IGF-1) deficiency on human hair growth and differentiation. According to its expression in the dermal hair papilla, IGF-1 is likely involved in reciprocal signaling. It has been shown to affect follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation, identifying IGF-1 signaling as an important mitogenic and morphogenetic regulator in hair follicle biology...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29740659/alopecia-areata-is-associated-with-increased-expression-of-heart-disease-biomarker-cardiac-troponin-i
#5
Eddy Hsi Wang, Leopoldo Santos, Xi Yuan Li, Annie Tran, Sandra S Y Kim, Katrina Woo, Jerry Shapiro, Kevin J McElwee
The development of androgenetic alopecia is associated with a risk of developing cardiovascular diseases, but the association of alopecia areata with cardiovascular diseases in humans is largely unexplored. We measured the plasma level of two common cardiovascular disease markers, cardiac troponin I and C-reactive protein, in alopecia areata and androgenetic alopecia affected subjects. Also, we investigated the possible presence of pro-apoptotic factors in the plasma of hair loss subjects. The mean plasma cardiac troponin I level was highest in alopecia areata subjects, moderately higher in androgenetic alopecia subjects, and lowest in subjects without hair loss (p < 0...
May 8, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29723381/the-tendency-towards-the-development-of-psychosexual-disorders-in-androgenetic-alopecia-according-to-the-different-stages-of-hair-loss-a-cross-sectional-study
#6
Betul Tas, Filiz Kulacaoglu, Hasan Belli, Murat Altuntas
BACKGROUND: Androgenetic alopecia is a common dermatological condition affecting both genders. OBJECTIVE: To evaluate the tendency towards development of psychosexual disorders according to the clinical stages of androgenetic alopecia. METHODS: A cross-sectional study was conducted including 353 patients of both sexes on different clinical stages of hair loss, and the patients were enquired about self-perception, self-esteem, sexual experiences, anxiety and depression states...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29707969/letter-to-editor-androgenetic-alopecia-drug-safety-and-therapeutic-strategies
#7
Gary Ong, Michael Manyak, Zrinka Lulic
No abstract text is available yet for this article.
April 30, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29707872/platelet-rich-plasma-on-female-androgenetic-alopecia-tested-on-10-patients
#8
Michela Starace, Aurora Alessandrini, Carmine D'Acunto, Davide Melandri, Francesca Bruni, Annalisa Patrizi, Bianca Maria Piraccini
BACKGROUND: Recently, platelet-rich plasma (PRP) injection has been proposed as a potential adjuvant therapy to treat androgenetic alopecia. AIMS: Investigate the efficacy, tolerability, and clinical improvement of PRP for the treatment of female AGA. PATIENTS/METHODS: A total of 10 female patients affected by AGA and not responding to treatment with minoxidil and/or oral antiandrogens were enrolled. The clinical improvement was evaluated by pull test, global photographs, and Trichoscan at weeks 9, 12, and 24, and hair measurements were performed at baseline and 12 and 24 weeks after the first session...
April 30, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29682736/medical-comorbidities-in-patients-with-lichen-planopilaris-a-retrospective-case-control-study
#9
Raymond M Fertig, Shasa Hu, Austin J Maddy, Alexandra Balaban, Nouf Aleid, Adam Aldahan, Antonella Tosti
BACKGROUND: Lichen planopilaris (LPP) is a rare inflammatory lymphocyte-mediated disease of the scalp considered to have an autoimmune pathogenesis. OBJECTIVES: To identify the prevalence of medical comorbidities in patients with classic LPP (CLPP) and frontal fibrosing alopecia (FFA). METHODS: The medical records of 206 LPP patients and 323 control patients were retrospectively reviewed for existing comorbidities. The control group consisted of 257 patients with androgenetic alopecia (ICD 9 = 704...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29675596/post-finasteride-syndrome-and-post-ssri-sexual-dysfunction-two-sides-of-the-same-coin
#10
REVIEW
Silvia Giatti, Silvia Diviccaro, Giancarlo Panzica, Roberto Cosimo Melcangi
Sexual dysfunction is a clinical condition due to different causes including the iatrogenic origin. For instance, it is well known that sexual dysfunction may occur in patients treated with antidepressants like selective serotonin reuptake inhibitors (SSRI). A similar side effect has been also reported during treatment with finasteride, an inhibitor of the enzyme 5alpha-reductase, for androgenetic alopecia. Interestingly, sexual dysfunction persists in both cases after drug discontinuation. These conditions have been named post-SSRI sexual dysfunction (PSSD) and post-finasteride syndrome (PFS)...
April 19, 2018: Endocrine
https://www.readbyqxmd.com/read/29672877/taking-advantage-from-phenotype-variability-in-a-local-animal-genetic-resource-identification-of-genomic-regions-associated-with-the-hairless-phenotype-in-casertana-pigs
#11
G Schiavo, F Bertolini, V J Utzeri, A Ribani, C Geraci, L Santoro, C Óvilo, A I Fernández, M Gallo, L Fontanesi
Casertana is an endangered autochthonous pig breed (raised in south-central Italy) that is considered to be the descendant of the influential Neapolitan pig population that was used to improve British breeds in the 19th century. Casertana pigs are characterized by a typical, almost complete, hairless phenotype, even though a few Casertana pigs are normal haired. In this work, using Illumina PorcineSNP60 BeadChip data, we carried out a genome-wide association study and an FST analysis with this breed by comparing animals showing the classical hairless phenotype (n = 81) versus pigs classified as haired (n = 15)...
April 19, 2018: Animal Genetics
https://www.readbyqxmd.com/read/29667763/prospective-randomized-study-of-sexual-function-in-men-taking-dutasteride-for-the-treatment-of-androgenetic-alopecia
#12
Tsen-Fang Tsai, Gwang Seong Choi, Beom Joon Kim, Moon-Bum Kim, Chi Fai Ng, Puja Kochhar, Stacy Jasper, Betsy Brotherton, Barbara Orban, Zrinka Lulic
Treatment with 5α-reductase inhibitors has been associated with sexual adverse events such as impotence (erectile dysfunction) and decreased libido. The primary objective of this study was to evaluate adverse events related to sexual function, based on their frequency, duration, persistence and associated treatment discontinuations, in men treated with dutasteride for androgenetic alopecia. Participants were randomized to receive double-blind dutasteride 0.5 mg or placebo once daily for 24 weeks, followed by open-label dutasteride 0...
April 18, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29659116/efficacy-and-safety-of-a-new-5-minoxidil-formulation-in-male-androgenetic-alopecia-a-randomized-placebo-controlled-double-blind-noninferiority-study
#13
Ulrike Blume-Peytavi, Zahida Issiakhem, Stephanie Gautier, Jan Kottner, Walter Wigger-Alberti, Tobias Fischer, Rolf Hoffmann, Françoise Tonner, Athmane Bouroubi, Jean-Jacques Voisard
BACKGROUND: Androgenetic alopecia (AGA) is the most common cause of hair loss in men. Topical minoxidil solutions can help to treat AGA but have to be applied continuously to be effective. OBJECTIVES: A new minoxidil formulation with improved cosmetic characteristics (DC0120, Pierre-Fabre Dermatologie) was tested for noninferiority vs a comparator minoxidil product (ALOSTIL® , Johnson & Johnson) in stimulating hair growth in men with AGA. METHODS: Two 10 cm2 areas on the scalp of each subject were randomized to receive DC0120, the comparator, or one of their corresponding vehicles, applied twice per day for 16 weeks...
April 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29656764/prescribing-habits-for-androgenic-alopecia-among-dermatologists-in-spain-in-2017-a-cross-sectional-study
#14
C Pindado-Ortega, D Saceda-Corralo, D Buendía-Castaño, P Fernández-González, Ó M Moreno-Arrones, P Fonda-Pascual, A Alegre-Sánchez, A R Rodrigues-Barata, S Vañó-Galván
BACKGROUND: Topical minoxidil and oral finasteride are the only drugs approved for the treatment of androgenetic alopecia (AGA) in Spain. However, the management of this condition is highly variable because numerous treatments are used off-label. The main aim of this study was to describe the prescribing habits of dermatologists in Spain for male AGA (MAGA) and female AGA (FAGA). MATERIAL AND METHODS: Descriptive cross-sectional study using online questionnaires completed by dermatologists working in Spain...
April 12, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29606834/medical-comorbidities-and-the-onset-of-androgenetic-alopecia-a-population-based-case-control-study
#15
Hee-Chul Chung, Sung Jay Choe, Solam Lee, Sung-Soo Oh, Won-Soo Lee
No abstract text is available yet for this article.
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29601622/a-systematic-review-of-topical-finasteride-in-the-treatment-of-androgenetic-alopecia-in-men-and-women
#16
Sung Won Lee, Margit Juhasz, Pezhman Mobasher, Chloe Ekelem, Natasha Atanaskova Mesinkovska
INTRODUCTION: Currently, only topical minoxidil (MNX) and oral finasteride (FNS) are approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of androgenetic alopecia. Although FNS is efficacious for hair regrowth, its systemic use is associated with side effects limiting long-term utilization. Exploring topical FNS as an alternative treatment regimen may prove promising. METHODS: A search was conducted to identify studies regarding human in vivo topical FNS treatment efficacy including clinically relevant case reports, randomized controlled trials (RCTs), and prospective studies...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29595184/genetic-and-molecular-aspects-of-androgenetic-alopecia
#17
REVIEW
Lizeth Martinez-Jacobo, César D Villarreal-Villarreal, Rocío Ortiz-López, Jorge Ocampo-Candiani, Augusto Rojas-Martínez
Androgenetic alopecia is the most common form of progressive hair loss in humans. A genetic predisposition and hormonal status are considered as major risk factors for this condition. Several recent advances in molecular biology and genetics have increased our understanding of the mechanisms of hair loss in androgenetic alopecia. We review these advances and examine the trends in the genetic and molecular aspects of androgenetic alopecia.
May 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29588248/non-malignant-late-cutaneous-changes-after-allogeneic-hematopoietic-stem-cell-transplant-in-children
#18
Jennifer T Huang, Johanna S Song, Elena B Hawryluk, Wendy B London, Dongjing Guo, Madhumitha Sridharan, David E Fisher, Leslie E Lehmann, Christine N Duncan
BACKGROUND: There are limited pediatric data on non-malignant cutaneous changes, including autoimmune conditions and permanent alopecia, after hematopoietic stem cell transplantation (HSCT). OBJECTIVE: We sought to characterize late cutaneous changes and associated risk factors after allogeneic HSCT in children. METHODS: A cross-sectional cohort study of pediatric HSCT recipients was performed at a single institution. All participants underwent a full skin examination...
March 24, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29580860/trichologic-response-of-platelet-rich-plasma-in-androgenetic-alopecia-is-maintained-during-combination-therapy
#19
Anthony Ho, Kumar Sukhdeo, Kristen Lo Sicco, Jerry Shapiro
No abstract text is available yet for this article.
March 23, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29574572/drug-treatment-for-androgenetic-alopecia-first-italian-questionnaire-survey-on-what-dermatologists-think-about-finasteride
#20
Elisabetta Sorbellini, Daniela Pinto, Barbara Marzani, Fabio Rinaldi
INTRODUCTION: Treatment with finasteride 1 mg/day represents the therapy of choice for androgenetic alopecia (AGA). We investigated how Italian dermatologists approach use of finasteride for treatment of AGA and common side effects reported by patients. METHODS: A tablet-based survey was conducted from February 2017 to January 2018 in Italy to investigating use of 1 mg/day finasteride in the treatment of AGA. Approximately 1153 Italian dermatologists were surveyed about prescription frequency, therapy duration, treatment practices, and side effects eventually reported...
March 24, 2018: Dermatology and Therapy
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