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Francesco Nieddu, Maria Moriondo, Elisa De Vitis, Silvia Ricci, Giuseppe Indolfi, Massimo Resti, Caterina Vocale, Maria Paola Landini, Assunta Sartor, Chiara Azzari
BACKGROUND AND AIM OF THE WORK: In 2010 PCV13 replaced PCV7 in the pediatric vaccination schedule for Italian children. While a strong herd effect was demonstrated for PCV7, a possible herd effect due to PCV13 is still under debate. Our aim was to evaluate differences in the distribution of pneumococcal serotypes between the pre and post-PCV13 eras in unvaccinated Italian adolescents and adults with laboratory-confirmed pneumococcal infection from 3 Italian Regions with a high rate of PCV13 vaccination of children...
February 9, 2017: Vaccine
Kazufumi Shimizu, Laksmi Wulandari, Emmanuel D Poetranto, Retno A Setyoningrum, Resti Yudhawati, Amelia Sholikhah, Aldise M Nastri, Anna L Poetranto, Adithya Y R Candra, Edith F Puruhito, Yusuke Takahara, Yoshiaki Yamagishi, Masaoki Yamaoka, Hak Hotta, Takako Ustumi, Maria I Lusida, Soetjipto, Yohko K Shimizu, Gatot Soegiarto, Yasuko Mori
BACKGROUND:  In Indonesia, highly pathogenic avian influenza A(H5N1) virus has become endemic in poultry and has caused sporadic deadly infections in human. Since 2012, we have conducted fixed-point surveillance of avian influenza viruses at a live-poultry market in East Java, Indonesia. In this study, we examined the seroprevalence of avian influenza A(H5N1) virus infection among market workers. METHODS:  Sera were collected from 101 workers in early 2014 and examined for antibody activity against avian A(H5N1) Eurasian lineage virus by a hemagglutination-inhibition (HI) assay...
December 15, 2016: Journal of Infectious Diseases
Titus Alicai, Joseph Ndunguru, Peter Sseruwagi, Fred Tairo, Geoffrey Okao-Okuja, Resty Nanvubya, Lilliane Kiiza, Laura Kubatko, Monica A Kehoe, Laura M Boykin
Cassava is a major staple food for about 800 million people in the tropics and sub-tropical regions of the world. Production of cassava is significantly hampered by cassava brown streak disease (CBSD), caused by Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). The disease is suppressing cassava yields in eastern Africa at an alarming rate. Previous studies have documented that CBSV is more devastating than UCBSV because it more readily infects both susceptible and tolerant cassava cultivars, resulting in greater yield losses...
November 3, 2016: Scientific Reports
Joseph Resti, Pulsar Li, Steven L Orebaugh
No abstract text is available yet for this article.
November 2016: Medical Education
Daniela Garib, Rita De Cássia Moura Carvalho Lauris, Louise Resti Calil, Arthur César De Medeiros Alves, Guilherme Janson, Araci Malagodi De Almeida, Lúcia Helena Soares Cevidanes, José Roberto Pereira Lauris
INTRODUCTION: The purpose of this 2-arm parallel study was to evaluate the dentoskeletal effects of rapid maxillary expansion with differential opening (EDO) compared with the hyrax expander in patients with complete bilateral cleft lip and palate. METHODS: A sample of patients with complete bilateral cleft lip and palate was prospectively and consecutively recruited. Eligibility criteria included participants in the mixed dentition with lip and palate repair performed during early childhood and maxillary arch constriction with a need for maxillary expansion before the alveolar bone graft procedure...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
Giuseppe Indolfi, Gabriella Nebbia, Mara Cananzi, Anna Maccabruni, Marco Zaramella, Lorenzo D'Antiga, Laura Grisotto, Chiara Azzari, Massimo Resti
BACKGROUND: Chronic hepatitis C is a global health problem. While new, highly effective and safe direct acting antivirals have been approved for adults, the only drugs currently registered for children are pegylated interferon and ribavirin. The timelines for the pediatric approval of the new treatment regimens are far off. Three phase II-III pediatric trials with direct acting antivirals are recruiting and the estimated dates of completion of these studies range between April 2018 and January 2023...
September 15, 2016: Pediatric Infectious Disease Journal
Edward N Kankaka, Teddy Murungi, Godfrey Kigozi, Frederick Makumbi, Dorean Nabukalu, Stephen Watya, Nehemiah Kighoma, Resty Nampijja, Daniel Kayiwa, Fred Nalugoda, David Serwadda, Maria Wawer, Ronald H Gray
OBJECTIVES: To assess the safety and acceptability of early infant circumcision (EIC) provided by trained clinical officers (COs) and registered nurse midwives (RNMWs) in rural Uganda. SUBJECTS AND METHODS: We conducted a randomised trial of EIC using the Mogen clamp provided by newly trained COs and RNMWs in four health centres in rural Rakai, Uganda. The trial was registered with # NCT02596282. In all, 501 healthy neonates aged 1-28 days with normal birth weight and gestational age were randomised to COs (n = 256) and RNMWs (n = 245) for EIC, and were followed-up at 1, 7 and 28 days...
January 2017: BJU International
Jess Morhayim, Resti Rudjito, Johannes P van Leeuwen, Marjolein van Driel
Extracellular vesicles (EVs), spherical bilayered proteolipids, behave as paracrine effectors since they are released from cells to deliver signals to other cells. They control a diverse range of biological processes by transferring proteins, lipids, and nucleic acids between cells and are secreted by a wide spectrum of cell types and are found in various biological fluids. EVs are formed at the plasma membrane or in endosomes and are heterogeneous in size and composition. Increasing understanding of the working mechanisms is promising for therapeutic and diagnostic opportunities...
2016: Current Molecular Biology Reports
Giuseppe Indolfi, Giusi Mangone, Elisa Bartolini, Maria Moriondo, Chiara Azzari, Massimo Resti
No abstract text is available yet for this article.
May 7, 2016: Lancet
Chiara Azzari, Francesco Nieddu, Maria Moriondo, Giuseppe Indolfi, Clementina Canessa, Silvia Ricci, Leila Bianchi, Daniele Serranti, Giovanni Maria Poggi, Massimo Resti
Knowing the incidence of invasive meningococcal disease (IMD) is essential for planning appropriate vaccination policies. However, IMD may be underestimated because of misdiagnosis or insufficiently sensitive laboratory methods. Using a national molecular surveillance register, we assessed the number of cases misdiagnosed and diagnoses obtained postmortem with real-time PCR (rPCR), and we compared sensitivity of rPCR versus culture-based testing. A total of 222 IMD cases were identified: 11 (42%) of 26 fatal cases had been misdiagnosed or undiagnosed and were reclassified as IMD after rPCR showed meningococcal DNA in all available specimens taken postmortem...
March 2016: Emerging Infectious Diseases
Arum Widyasari-Mehta, Hanna Resti Kartika Ayu Suwito, Robert Kreuzig
The veterinary antibiotic doxycycline (DOXY) is today frequently applied in conventional pig husbandry for the control of respiratory diseases. After the treatment, pigs excrete major amounts of DOXY as the unchanged active substance. Thus, DOXY residues were found in liquid manures and digestates of biogas plants at concentrations of mg kg(-1) dry weight. In order to assess the impact of field applications of contaminated manures and digestates on the entry of DOXY residues into arable and grassland soils, thorough information about the removal of DOXY during long-term storage of farm fertilizers is required...
April 2016: Chemosphere
Chiara Azzari, Martina Cortimiglia, Francesco Nieddu, Maria Moriondo, Giuseppe Indolfi, Romano Mattei, Massimo Zuliani, Beatrice Adriani, Roberto Degl'Innocenti, Guglielmo Consales, Donatella Aquilini, Giancarlo Bini, Massimo Edoardo Di Natale, Clementina Canessa, Silvia Ricci, Elisa de Vitis, Giusi Mangone, Angela Bechini, Paolo Bonanni, Angela Pasinato, Massimo Resti
The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas...
2016: Human Vaccines & Immunotherapeutics
Arthur César de Medeiros Alves, Daniela Gamba Garib, Guilherme Janson, Araci Malagodi de Almeida, Louise Resti Calil
OBJECTIVES: The purpose of this study was to compare the dentoalveolar effects of slow (SME) and rapid (RME) maxillary expansions in patients with complete bilateral cleft lip and palate (BCLP). MATERIAL AND METHODS: A sample of 50 patients with BCLP and maxillary arch constriction was randomly and equally allocated into two groups. Group SME comprised patients (mean age of 8.8 years) treated with quad-helix appliance. Group RME comprised individuals (mean age of 8...
September 2016: Clinical Oral Investigations
G Indolfi, G Mangone, M Moriondo, D Serranti, E Bartolini, C Azzari, M Resti
BACKGROUND: Natural killer (NK) cells number, phenotypes and function have been evaluated in many studies in adults with hepatitis C as compared with healthy controls or dynamically during interferon-based and interferon-free treatments. Overall, in adults with chronic infection number of circulating NK cells has been reported to be lower when compared to spontaneous resolvers and healthy subjects. Different studies yielded inconsistent findings due to patient and virus heterogeneity...
January 2016: Alimentary Pharmacology & Therapeutics
Giancarlo la Marca, Elisa Giocaliere, Sabrina Malvagia, Fabio Villanelli, Silvia Funghini, Daniela Ombrone, Maria Della Bona, Giulia Forni, Clementina Canessa, Silvia Ricci, Francesca Romano, Renzo Guerrini, Massimo Resti, Chiara Azzari
BACKGROUND: Purine nucleoside phosphorylase (PNP) deficiency has been recently introduced in the newborn screening program in Tuscany. In order to improve the PNP screening efficiency, we developed a 2nd tier test to quantify PNP primary markers deoxyguanosine (dGuo) and deoxyinosine (dIno). METHODS: Dried blood spots (DBS) samples were extracted with 200 μL of methanol and 100 μL of water (by two steps). Internal standards were added at a final concentration of 10 μmol/L...
April 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Giuseppe Indolfi, Maria Guido, Chiara Azzari, Massimo Resti
Chronic hepatitis C in children is usually considered a clinically mild and slowly progressive disease. Few pediatric studies focused on histopathology of children with hepatitis C are available. Those available show, overall, a wide spectrum of findings ranging from normal liver to cirrhosis and hepatocellular carcinoma. The present systematic review provides a comprehensive overview of the studies that explored histopathology in children with hepatitis C. Factors affecting the presence and the degree of necroinflammation, fibrosis and steatosis and the risk of progression to advanced liver disease were extensively evaluated...
2015: Expert Review of Anti-infective Therapy
Giuseppe Indolfi, Elisa Bartolini, Daniele Serranti, Chiara Azzari, Massimo Resti
OBJECTIVES: The objective of this systematic review was to summarize evidence regarding hepatitis C in hepatitis C virus/human immunodeficiency virus (HCV/HIV)-co-infected children focusing on mother-to-child transmission, clinical and laboratory features, outcome, and therapies. METHODS: A literature search was performed using multiple keywords and standardized terminology in MEDLINE, EMBASE, and Cochrane databases dating back to their inception up to April 1, 2015, using the following terms hepatitis C virus, HIV, and child...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
Monica Paci, Elena Chiappini, Sandra Trapani, Massimo Resti, Paolo Lionetti
No abstract text is available yet for this article.
July 2015: Journal of Pediatric Gastroenterology and Nutrition
Daniela G Garib, Louise Resti Calil, Claudia Resende Leal, Guilherme Janson
This article aims to discuss current evidence and recommendations for cone-beam computed tomography (CBCT) in Orthodontics. In comparison to conventional radiograph, CBCT has higher radiation doses and, for this reason, is not a standard method of diagnosis in Orthodontics. Routine use of CBCT in substitution to conventional radiograph is considered an unaccepted practice. CBCT should be indicated with criteria only after clinical examination has been performed and when the benefits for diagnosis and treatment planning exceed the risks of a greater radiation dose...
September 2014: Dental Press Journal of Orthodontics
Gillian H Gile, Erick R James, Noriko Okamoto, Kevin J Carpenter, Rudolf H Scheffrahn, Patrick J Keeling
Macrotrichomonas (Cristamonadea: Parabasalia) is an anaerobic, amitochondriate flagellate symbiont of termite hindguts. It is noteworthy for being large but not structurally complex compared with other large parabasalians, and for retaining a structure similar in appearance to the undulating membrane (UM) of small flagellates closely related to cristamonads, e.g. Tritrichomonas. Here, we have characterised the SSU rDNA from two species described as Macrotrichomonas: M. restis Kirby 1942 from Neotermes jouteli and M...
July 2015: Journal of Eukaryotic Microbiology
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