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Alice Brambilla, Cristina Pizza, Donatella Lasagni, Lucia Lachina, Massimo Resti, Sandra Trapani
Vitamin C deficiency is anecdotal in developed countries, mainly associated with underling clinical morbidities as autism or neurological impairment. Chronic insufficient dietary supply is responsible for vascular fragility and impaired bone formation, resulting in gingival bleeding, petechial lesions, articular and bone pain or limb swelling. Children may present anorexia, irritability, failure to thrive, limping or refusal to walk. Accordingly, pediatric scurvy is frequently misdiagnosed with osteomyelitis, septic arthritis, bone and soft tissue tumor, leukemia, bleeding disorders, and rheumatologic conditions...
2018: Frontiers in Pediatrics
Atika Resti Fitri, Prasit Pavasant, Supakarn Chamni, Piyamas Sumrejkanchanakij
BACKGROUND: Asiaticoside is a compound isolated from Herb Centella asiatica, which has been shown to promote osteogenic differentiation of human periodontal ligament (hPDL) cells. This study investigated the molecular mechanism underlying the asiaticoside-induced osteogenic differentiation of hPDL cells. METHODS: hPDL cells were incubated with various concentrations of asiaticoside to test cell viability by MTT assay. The mRNA expression levels were analyzed by using quantitative real-time polymerase chain reaction (PCR)...
February 22, 2018: Journal of Periodontology
Sandra Trapani, Alessandra Montemaggi, Eleonora Dini, Anna Pozzessere, Maria Alice Donati, Massimo Resti
No abstract text is available yet for this article.
December 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Daniele Serranti, Giuseppe Indolfi, Gabriella Nebbia, Mara Cananzi, Lorenzo D'Antiga, Silvia Ricci, Stefano Stagi, Chiara Azzari, Massimo Resti
BACKGROUND: Autoimmune thyroid disease and thyroid dysfunction are common in adults receiving interferon (IFN)-based treatment for chronic hepatitis C (CHC). Few data are available in children with CHC. This study is aimed to evaluate the appearance and timing of thyroid dysfunction and antithyroid autoimmunity in children with CHC treated with pegylated IFN-α-2b and ribavirin (RBV). METHODS: Sixty-one otherwise healthy children with CHC, 3-17 years of age, infected perinatally and treatment naïve, receiving therapy with pegylated IFN-α-2b and RBV and 183 age- and sex-matched controls were included in a multicenter, prospective, case-control study...
April 2018: Pediatric Infectious Disease Journal
Rita de Cássia Moura Carvalho Lauris, Leopoldino Capelozza, Louise Resti Calil, José Roberto Pereira Lauris, Guilherme Janson, Daniela Gamba Garib
Objective: The aim of this study was to evaluate the facial profile esthetics of rehabilitated children with complete bilateral cleft lip and palate (BCLP), comparing the judgment of professionals related and not related to cleft rehabilitation and laypersons. Methods: Thirty children in the mixed dentition (24 male; 6 female) with a mean age of 7.8 years were evaluated using facial profile photographs by 25 examiners: 5 orthodontists and 5 plastic surgeons with experience in cleft care, 5 orthodontists and 5 plastic surgeons without experience in oral cleft rehabilitation and 5 graduated laymen...
July 2017: Dental Press Journal of Orthodontics
Giuseppe Indolfi, Maria Iascone, Giulia Remaschi, Maria Alice Donati, Claudia Nesti, Anna Rubegni, Laura Pezzoli, Anna Maria Buccoliero, Filippo Maria Santorelli, Massimo Resti
No abstract text is available yet for this article.
May 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
Francesco Nieddu, Maria Moriondo, Elisa De Vitis, Silvia Ricci, Giuseppe Indolfi, Massimo Resti, Caterina Vocale, Maria Paola Landini, Assunta Sartor, Chiara Azzari
BACKGROUND AND AIM OF THE WORK: In 2010 PCV13 replaced PCV7 in the pediatric vaccination schedule for Italian children. While a strong herd effect was demonstrated for PCV7, a possible herd effect due to PCV13 is still under debate. Our aim was to evaluate differences in the distribution of pneumococcal serotypes between the pre and post-PCV13 eras in unvaccinated Italian adolescents and adults with laboratory-confirmed pneumococcal infection from 3 Italian Regions with a high rate of PCV13 vaccination of children...
March 13, 2017: Vaccine
Kazufumi Shimizu, Laksmi Wulandari, Emmanuel D Poetranto, Retno A Setyoningrum, Resti Yudhawati, Amelia Sholikhah, Aldise M Nastri, Anna L Poetranto, Adithya Y R Candra, Edith F Puruhito, Yusuke Takahara, Yoshiaki Yamagishi, Masaoki Yamaoka, Hak Hotta, Takako Ustumi, Maria I Lusida, Soetjipto, Yohko K Shimizu, Gatot Soegiarto, Yasuko Mori
BACKGROUND:  In Indonesia, highly pathogenic avian influenza A(H5N1) virus has become endemic in poultry and has caused sporadic deadly infections in human. Since 2012, we have conducted fixed-point surveillance of avian influenza viruses at a live-poultry market in East Java, Indonesia. In this study, we examined the seroprevalence of avian influenza A(H5N1) virus infection among market workers. METHODS:  Sera were collected from 101 workers in early 2014 and examined for antibody activity against avian A(H5N1) Eurasian lineage virus by a hemagglutination-inhibition (HI) assay...
December 15, 2016: Journal of Infectious Diseases
Titus Alicai, Joseph Ndunguru, Peter Sseruwagi, Fred Tairo, Geoffrey Okao-Okuja, Resty Nanvubya, Lilliane Kiiza, Laura Kubatko, Monica A Kehoe, Laura M Boykin
Cassava is a major staple food for about 800 million people in the tropics and sub-tropical regions of the world. Production of cassava is significantly hampered by cassava brown streak disease (CBSD), caused by Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). The disease is suppressing cassava yields in eastern Africa at an alarming rate. Previous studies have documented that CBSV is more devastating than UCBSV because it more readily infects both susceptible and tolerant cassava cultivars, resulting in greater yield losses...
November 3, 2016: Scientific Reports
Joseph Resti, Pulsar Li, Steven L Orebaugh
No abstract text is available yet for this article.
November 2016: Medical Education
Daniela Garib, Rita De Cássia Moura Carvalho Lauris, Louise Resti Calil, Arthur César De Medeiros Alves, Guilherme Janson, Araci Malagodi De Almeida, Lúcia Helena Soares Cevidanes, José Roberto Pereira Lauris
INTRODUCTION: The purpose of this 2-arm parallel study was to evaluate the dentoskeletal effects of rapid maxillary expansion with differential opening (EDO) compared with the hyrax expander in patients with complete bilateral cleft lip and palate. METHODS: A sample of patients with complete bilateral cleft lip and palate was prospectively and consecutively recruited. Eligibility criteria included participants in the mixed dentition with lip and palate repair performed during early childhood and maxillary arch constriction with a need for maxillary expansion before the alveolar bone graft procedure...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
Giuseppe Indolfi, Gabriella Nebbia, Mara Cananzi, Anna Maccabruni, Marco Zaramella, Lorenzo D'Antiga, Laura Grisotto, Chiara Azzari, Massimo Resti
BACKGROUND: Chronic hepatitis C is a global health problem. Although new, highly effective and safe direct-acting antivirals have been approved for adults, the only drugs currently registered for children are pegylated interferon and ribavirin. The timelines for the pediatric approval of the new treatment regimens are far off. Three phase II-III pediatric trials with direct-acting antivirals are recruiting, and the estimated dates of completion of these studies range between April 2018 and January 2023...
December 2016: Pediatric Infectious Disease Journal
Edward N Kankaka, Teddy Murungi, Godfrey Kigozi, Frederick Makumbi, Dorean Nabukalu, Stephen Watya, Nehemiah Kighoma, Resty Nampijja, Daniel Kayiwa, Fred Nalugoda, David Serwadda, Maria Wawer, Ronald H Gray
OBJECTIVES: To assess the safety and acceptability of early infant circumcision (EIC) provided by trained clinical officers (COs) and registered nurse midwives (RNMWs) in rural Uganda. SUBJECTS AND METHODS: We conducted a randomised trial of EIC using the Mogen clamp provided by newly trained COs and RNMWs in four health centres in rural Rakai, Uganda. The trial was registered with # NCT02596282. In all, 501 healthy neonates aged 1-28 days with normal birth weight and gestational age were randomised to COs (n = 256) and RNMWs (n = 245) for EIC, and were followed-up at 1, 7 and 28 days...
January 2017: BJU International
Jess Morhayim, Resti Rudjito, Johannes P van Leeuwen, Marjolein van Driel
Extracellular vesicles (EVs), spherical bilayered proteolipids, behave as paracrine effectors since they are released from cells to deliver signals to other cells. They control a diverse range of biological processes by transferring proteins, lipids, and nucleic acids between cells and are secreted by a wide spectrum of cell types and are found in various biological fluids. EVs are formed at the plasma membrane or in endosomes and are heterogeneous in size and composition. Increasing understanding of the working mechanisms is promising for therapeutic and diagnostic opportunities...
2016: Current Molecular Biology Reports
Giuseppe Indolfi, Giusi Mangone, Elisa Bartolini, Maria Moriondo, Chiara Azzari, Massimo Resti
No abstract text is available yet for this article.
May 7, 2016: Lancet
Chiara Azzari, Francesco Nieddu, Maria Moriondo, Giuseppe Indolfi, Clementina Canessa, Silvia Ricci, Leila Bianchi, Daniele Serranti, Giovanni Maria Poggi, Massimo Resti
Knowing the incidence of invasive meningococcal disease (IMD) is essential for planning appropriate vaccination policies. However, IMD may be underestimated because of misdiagnosis or insufficiently sensitive laboratory methods. Using a national molecular surveillance register, we assessed the number of cases misdiagnosed and diagnoses obtained postmortem with real-time PCR (rPCR), and we compared sensitivity of rPCR versus culture-based testing. A total of 222 IMD cases were identified: 11 (42%) of 26 fatal cases had been misdiagnosed or undiagnosed and were reclassified as IMD after rPCR showed meningococcal DNA in all available specimens taken postmortem...
March 2016: Emerging Infectious Diseases
Arum Widyasari-Mehta, Hanna Resti Kartika Ayu Suwito, Robert Kreuzig
The veterinary antibiotic doxycycline (DOXY) is today frequently applied in conventional pig husbandry for the control of respiratory diseases. After the treatment, pigs excrete major amounts of DOXY as the unchanged active substance. Thus, DOXY residues were found in liquid manures and digestates of biogas plants at concentrations of mg kg(-1) dry weight. In order to assess the impact of field applications of contaminated manures and digestates on the entry of DOXY residues into arable and grassland soils, thorough information about the removal of DOXY during long-term storage of farm fertilizers is required...
April 2016: Chemosphere
Chiara Azzari, Martina Cortimiglia, Francesco Nieddu, Maria Moriondo, Giuseppe Indolfi, Romano Mattei, Massimo Zuliani, Beatrice Adriani, Roberto Degl'Innocenti, Guglielmo Consales, Donatella Aquilini, Giancarlo Bini, Massimo Edoardo Di Natale, Clementina Canessa, Silvia Ricci, Elisa de Vitis, Giusi Mangone, Angela Bechini, Paolo Bonanni, Angela Pasinato, Massimo Resti
The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas...
2016: Human Vaccines & Immunotherapeutics
Arthur César de Medeiros Alves, Daniela Gamba Garib, Guilherme Janson, Araci Malagodi de Almeida, Louise Resti Calil
OBJECTIVES: The purpose of this study was to compare the dentoalveolar effects of slow (SME) and rapid (RME) maxillary expansions in patients with complete bilateral cleft lip and palate (BCLP). MATERIAL AND METHODS: A sample of 50 patients with BCLP and maxillary arch constriction was randomly and equally allocated into two groups. Group SME comprised patients (mean age of 8.8 years) treated with quad-helix appliance. Group RME comprised individuals (mean age of 8...
September 2016: Clinical Oral Investigations
G Indolfi, G Mangone, M Moriondo, D Serranti, E Bartolini, C Azzari, M Resti
BACKGROUND: Natural killer (NK) cells number, phenotypes and function have been evaluated in many studies in adults with hepatitis C as compared with healthy controls or dynamically during interferon-based and interferon-free treatments. Overall, in adults with chronic infection number of circulating NK cells has been reported to be lower when compared to spontaneous resolvers and healthy subjects. Different studies yielded inconsistent findings due to patient and virus heterogeneity...
January 2016: Alimentary Pharmacology & Therapeutics
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