keyword
https://read.qxmd.com/read/38511727/effect-of-different-doses-of-sugammadex-on-recovery-and-hemodynamic-parameters-in-reversing-neuromuscular-blockade-in-patients-undergoing-electroconvulsive-therapy
#21
JOURNAL ARTICLE
Kadir Arslan, Gozde Kucuksarac, Hale Cetin Arslan, Erkan Aydin, Ayca Sultan Sahin
OBJECTIVE: This retrospective observational study aimed to investigate the effect of different doses of sugammadex used in reversing neuromuscular blockade in electroconvulsive therapy (ECT) procedures on patient recovery and hemodynamic measurements. METHODS: Anesthesia induction was performed using propofol (1 mg/kg) and rocuronium (0.4 mg/kg). Patients were classified into group 2 (2 mg/kg) and group 3 (3 mg/kg) according to the dose of sugammadex used to reverse neuromuscular blockade...
March 21, 2024: Medeniyet medical journal
https://read.qxmd.com/read/38509586/managing-a-difficult-airway-due-to-supraglottic-masses-successful-videolaryngoscopic-intubation-after-induction-of-general-anesthesia
#22
JOURNAL ARTICLE
Hye-Won Jeong, Eun-Jin Song, Eun-A Jang, Joungmin Kim
BACKGROUND: While awake, flexible bronchoscopic intubation has long been considered the gold standard for managing anticipated difficult airways, the videolaryngoscope has emerged as a viable alternative. In addition, the decision to perform awake intubation or to proceed with airway management after induction of general anesthesia should be grounded in a comprehensive assessment of risks and benefits. CASE PRESENTATION: A 41-year old female patient was scheduled for excision of bilateral, mobile, and pedunculated masses on both aryepiglottic folds, which covered almost the entire upper part of the glottis...
March 20, 2024: Perioperative Medicine
https://read.qxmd.com/read/38506690/comment-on-hemodynamic-influences-of-remimazolam-versus-propofol-during-the-induction-period-of-general-anesthesia
#23
JOURNAL ARTICLE
I-Wen Chen, Wei-Ting Wang, Kuo-Chuan Hung
No abstract text is available yet for this article.
March 2024: Pain Physician
https://read.qxmd.com/read/38502679/a-rotational-study-of-2-tert-butylphenol-and-its-1-1-argon-complex
#24
JOURNAL ARTICLE
Wenqin Li, Domingo Heras, Assimo Maris, Sonia Melandri, Alberto Lesarri, Luca Evangelisti
The chirped-pulse Fourier Transform microwave spectrum of 2-tert-butylphenol, an industrial intermediate for the production of antioxidants, has been investigated in the 2-8 GHz frequency range. The spectral analysis has allowed obtaining precise structural information on the most stable conformer and its complex with argon. The conformation of the monomer reveals that the hydroxyl group is coplanar with the ring but points in the opposite direction to the tert-butyl group, reducing steric interactions. In the terbutyl group one methyl group is coplanar and the other two are symmetrically staggered respect to the ring...
March 19, 2024: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://read.qxmd.com/read/38499567/predicting-the-optimal-concentration-of-remifentanil-for-skull-pin-fixation-with-hemodynamic-and-analgesia-nociception-index-monitoring
#25
JOURNAL ARTICLE
Yi-Wei Kuo, Ying-Tzu Chen, Ann-Shung Lieu, Meei-Shyuan Lee, Yu-Feng Su, Hou-Chuan Lai, Zhi-Fu Wu
Inadequate antinociception during skull pin fixation may cause hemodynamic instability in intracranial surgery. The optimal concentration of remifentanil to provide adequate antinociception and stable hemodynamics during skull pin fixation under analgesia nociception index monitoring is unknown. This study is to assess the 90% effective concentration of remifentanil for skull pin fixation under hemodynamic and analgesia nociception index monitoring. Twenty-six patients were enrolled for intracranial surgery, anesthesia was induced and maintained under total intravenous anesthesia using target-controlled infusion for remifentanil and propofol under analgesia nociception index and bispectral index monitoring...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38498283/understanding-propofol-s-protective-mechanism-in-tubular-epithelial-cells-mitigating-pyroptosis-via-the-mir-143-3p-atpase-na%C3%A2-%C3%A2-k%C3%A2-%C3%A2-transporting-subunit-alpha-2-pathway-in-renal-ischemia-reperfusion
#26
JOURNAL ARTICLE
Hongjun Kan, Miaomiao Zhao, Wei Wang, Baozhong Sun
Propofol (Pro), a prevalent intravenous anesthetic, has recently been recognized for its potential in mitigating ischemia-reperfusion (I/R) injuries. Despite a plethora of evidence suggesting the beneficial effects of low-dose Pro in renal I/R injury (RI/R), its role in modulating pyroptosis in renal tubular epithelial cells consequent to RI/R has not been thoroughly elucidated. In our investigation, we explored the therapeutic potential of Pro against pyroptosis in renal tubular epithelial cells under the duress of RI/R, employing both in vivo and in vitro models, while deciphering the intricate molecular pathways involved...
March 18, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38495522/propofol-sedation-does-not-improve-measures-of-colonoscopy-quality-but-increase-cost-findings-from-a-large-population-based-cohort-study
#27
JOURNAL ARTICLE
Sheikh Rahman, Lauren E Cipriano, Cassandra McDonald, Sarah Cocco, Ziad Hindi, Debarati Chakraborty, Karissa French, Omar Siddiqi, Mayur Brahmania, Aze Wilson, Brian Yan, Leonardo Guizzetti, Vipul Jairath, Michael Sey
BACKGROUND: Propofol is often used for sedation during colonoscopy. We assessed the impact of propofol sedation on colonoscopy related quality metrics and cost in a population-based cohort study. METHODS: All colonoscopies performed at 21 hospitals in the province of Ontario, Canada, during an 18-month period, from April 1, 2017 to October 31, 2018, using either propofol or conscious sedation were evaluated. The primary outcome was adenoma detection rate (ADR) and secondary outcomes were sessile serrated polyp detection rate (ssPDR), polyp detection rate (PDR), cecal intubation rate (CIR), and perforation rate...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38494633/an-atypical-case-of-bilateral-optic-neuritis-after-strabismus-surgery-under-general-anesthesia
#28
JOURNAL ARTICLE
Himani Pal, Anupam Singh, Sandhya Shrestha, Indar Kumar Sharawat, Prateek Kumar Panda, Barun Kumar
INTRODUCTION: Strabismus surgery under general anesthesia is a common procedure with rare complications in the form of hemorrhage, infection, slipped muscle, lost muscle, scleral perforation, and anterior segment ischemia. We report a unique case of bilateral optic neuritis following squint surgery under general anesthesia in a 15-year-old girl. METHODS: A 15-year-old girl presented with accommodative esotropia with V pattern. She underwent uneventful bilateral inferior oblique recession surgery under general anesthesia with Propofol 60 mg, Atracurium 30 mg, and Fentanyl 70 mcg...
March 17, 2024: Strabismus
https://read.qxmd.com/read/38494158/comparison-of-the-bispectral-indices-of-patients-receiving-remimazolam-and-propofol-for-general-anesthesia-a-randomized-crossover-trial
#29
JOURNAL ARTICLE
Chen Yang, Jing Jiao, Yuyan Nie, Wenyu Shao, Hongwei Zhang, Shaoqiang Huang
BACKGROUND: Remimazolam is a safe and effective new benzodiazepine sedative that has unique advantages in anesthesia induction and maintenance. The differences in the electroencephalogram bispectral index (BIS) during general anesthesia between propofol and remimazolam deserve further exploration. METHODS: Single-center randomized crossover study. Patients who required multiple hysteroscopic surgery were randomly assigned to use remimazolam (0.27 mg/kg for induction and 1 mg/kg/h for maintenance) first and then propofol (2...
March 15, 2024: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/38493706/fospropofol-disodium-versus-propofol-for-long-term-sedation-during-invasive-mechanical-ventilation-a-pilot-randomized-clinical-trial
#30
JOURNAL ARTICLE
Xuehui Gao, Xiaobo Yang, Yun Tang, Xiangzhi Fang, Yin Yuan, Hong Qi, Ruiting Li, Huaqing Shu, Xiaojing Zou, You Shang
STUDY OBJECTIVE: Fospropofol disodium is a propofol prodrug that is water-soluble and has a reduced risk of bacterial contamination and hypertriglyceridemia compared with propofol. Prior to implementing a large randomized trial, we investigated the feasibility, initial efficacy, and safety of fospropofol disodium compared with propofol in long-term mild-to-moderate sedation in intensive care units (ICUs). DESIGN: Single-centered, prospective, unblind, randomized, parallel-group clinical trial...
March 16, 2024: Journal of Clinical Anesthesia
https://read.qxmd.com/read/38491119/development-of-extended-pharmacokinetic-models-for-propofol-based-on-measured-blood-and-brain-concentrations
#31
JOURNAL ARTICLE
Masayoshi Kawata, Atsushi Yonezawa, Yohei Mineharu, Kotaro Itohara, Toshiyuki Mizota, Yoshihiro Matsui, Takayuki Kikuchi, Yukihiro Yamao, Etsuko Yamamoto Hattori, Miho Hamada, Daiki Hira, Keiko Furukawa, Susumu Miyamoto, Tomohiro Terada, Kazuo Matsubara, Yoshiki Arakawa
Propofol's pharmacokinetics have been extensively studied using human blood samples and applied to target-controlled infusion systems; however, information on its concentration in the brain remains scarce. Therefore, this study aimed to simultaneously measure propofol plasma and brain concentrations in patients who underwent awake craniotomy and establish new pharmacokinetic model. Fifty-seven patients with brain tumors or brain lesions who underwent awake craniotomy were sequentially assigned to model-building and validating groups...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490349/reducing-hydrophobic-drug-adsorption-in-an-in-vitro-extracorporeal-membrane-oxygenation-model
#32
JOURNAL ARTICLE
Nitish Khurana, Kamiya Watkins, Debika Ghatak, Jane Staples, Oliver Hubbard, Venkata Yellepeddi, Kevin Watt, Hamidreza Ghandehari
Extracorporeal membrane oxygenation (ECMO) is a life-saving cardiopulmonary bypass technology for critically ill patients with heart and lung failure. Patients treated with ECMO receive a range of drugs that are used to treat underlying diseases and critical illnesses. However, the dosing guidelines for these drugs used in ECMO patients are unclear. Mortality rate for patients on ECMO exceeds 40% partly due to inaccurate dosing information, caused in part by the adsorption of drugs in the ECMO circuit and its components...
March 13, 2024: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/38487133/comparing-perioperative-outcomes-of-total-intravenous-anesthesia-tiva-with-volatile-anesthesia-in-patients-with-obesity-a-systematic-review
#33
REVIEW
Faiza A Kamal, Lucas Y Fernet, Naofal K Da Silva, Gabriela Briceño, Nusrath Iyoob, Kenneth Aleman Paredes, Marily Martinez Ramirez, Victor S Arruarana
In this systematic review, the perioperative outcomes of total intravenous anesthesia (TIVA) and volatile anesthesia were compared in obese adults (BMI ≥ 30 kg/m²) undergoing elective surgery. The review analyzed data from 12 randomized-controlled trials involving 935 patients, sourced from PubMed/MEDLINE (Medical Literature Analysis and Retrieval System Online), Cochrane, Scopus, and Web of Science databases. The focus was on intraoperative vital signs, emergence time, postoperative nausea and vomiting (PONV), duration of post-anesthesia care unit (PACU) stay, and ICU admission rates...
February 2024: Curēus
https://read.qxmd.com/read/38483219/antibiotics-sedatives-and-catecholamines-further-compromise-sepsis-induced-immune-suppression-in-peripheral-blood-mononuclear-cells
#34
JOURNAL ARTICLE
Muska Miller, Miranda J Melis, James R C Miller, Anna Kleyman, Manu Shankar-Hari, Mervyn Singer
OBJECTIVES: We hypothesized that the immunosuppressive effects associated with antibiotics, sedatives, and catecholamines amplify sepsis-associated immune suppression through mitochondrial dysfunction, and there is a cumulative effect when used in combination. We thus sought to determine the impact of the exemplar drugs ciprofloxacin, propofol, and norepinephrine, used alone and in combination, at clinically relevant concentrations, on the ex vivo functionality of peripheral blood mononuclear cells (PBMCs) drawn from healthy, infected, and septic individuals...
April 1, 2024: Critical Care Medicine
https://read.qxmd.com/read/38482637/neuropsychological-follow-up-of-isoflurane-sedated-intensive-care-patients-a-substudy-of-a-randomized-trial
#35
JOURNAL ARTICLE
Verena F Fuchs, Henrik V Simon, Nina Soldinger, Thomas Volk, Andreas Meiser
BACKGROUND: Inhaled sedation of intensive care unit (ICU) patients ventilated >24 hours may have long term effects. We hypothesized that isoflurane has a better neuropsychological outcome in a One-year follow-up compared to propofol sedation. METHODS: All 66 patients included by the coordinating center of the ISOCONDA study (EudraCT#: 2016-004551-67) took part in this substudy (DRKS00020240). A delirium test (CAM-ICU) was performed 24 hours after end of sedation...
March 14, 2024: Minerva Anestesiologica
https://read.qxmd.com/read/38482541/the-risk-of-delirium-after-sedation-with-propofol-or-midazolam-in-intensive-care-unit-patients
#36
JOURNAL ARTICLE
Thomas G van Gelder, Irene J van Diem-Zaal, Sandra M A Dijkstra-Kersten, Nikki de Mul, Arief Lalmohamed, Arjen J C Slooter
AIM: Knowledge of risk factors may provide strategies to reduce the high burden of delirium in intensive care unit (ICU) patients. We aimed to compare the risk of delirium after deep sedation with propofol versus midazolam in ICU patients. METHODS: In this prospective cohort study, ICU patients who were in an unarousable state for ≥24 h due to continuous sedation with propofol and/or midazolam were included. Patients admitted ≤24 h, those with an acute neurological disorder and those receiving palliative sedation were excluded...
March 14, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38482052/the-potential-anti-tumor-effect-of-anesthetics-on-cancer-by-regulating-autophagy
#37
REVIEW
Tiantian Wang, Zhixia Zhou, Kai Jiang, Yin Wang, Peifeng Li, Shoushi Wang
Autophagy is a conserved, cellular self-degradation system that is essential for maintaining intracellular homeostasis. Increasing evidence suggests that autophagy plays an important dual regulatory role in the development of many human diseases, such as cancer. Recent studies have shown that the autophagy process in tumor cells can be regulated by various stimuli from both intracellular and extracellular environments, including the effects of anesthesia. Anesthetics have been shown to not only have clinical anesthetic and sedative effects but also play important roles in the progression of tumors...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38481015/pharmacokinetics-of-propofol-in-severely-obese-surgical-patients
#38
JOURNAL ARTICLE
Martin Rygh Braathen, Ann E Rigby-Jones, Johan Raeder, Olav Spigset, Tom Heier
BACKGROUND: Existing PK models of propofol include sparse data from very obese patients. The aim of this study was to develop a PK model based on standardised surgical conditions and spanning from normal-weight up to, and including, a high number of very obese patients. METHODS: Adult patients scheduled for laparoscopic cholecystectomy or bariatric surgery were studied. Anaesthesia was induced with propofol 2 mg/kg adjusted body weight over 2 min followed by 6 mg/kg/h adjusted body weight over 30 min...
March 13, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38480661/adverse-drug-events-observed-with-the-newly-approved-remimazolam-in-comparison-to-propofol-for-general-anesthesia-in-patients-undergoing-surgery-a-meta-analysis
#39
JOURNAL ARTICLE
Lidan Huang, Hong Liu, Xue Zou, Jiawang Ding, Song Tao
INTRODUCTION: Developments in anesthetic pharmacology have been aiming at minimizing physiological disturbance in addition to maintaining and improving titrateability, recovery profile, and patient experience. Remimazolam, a GABAAlpha receptor agonist, is a new intravenous anesthetic agent which has recently been approved for use. This analysis aimed to systematically compare the adverse drug events reported with the newly approved remimazolam in comparison to propofol for general anesthesia (GA) in patients undergoing surgery...
March 13, 2024: Advances in Therapy
https://read.qxmd.com/read/38479189/propofol-modulates-nrf2-nlrp3-signaling-to-ameliorate-cigarette-smoke-induced-damage-in-human-bronchial-epithelial-cells
#40
JOURNAL ARTICLE
Linmei Xu, Yanbin Wang, Qumin Chen, Xiaolei Zhu, Jiageng Hong
Cigarette smoke extract (CSE) is known as a significant contributor to chronic obstructive pulmonary disease (COPD). Propofol, an anesthetic agent, has been studied for its potential protective effects against lung damage. This study aimed to elucidate the protective mechanisms of propofol against CSE-induced damage in human bronchial epithelial 16HBE cells. In CSE-induced 16HBE cells treated by propofol with or without transfection of nuclear factor erythroid 2-related factor 2 (Nrf2) interference plasmids, CCK-8 assay and lactate dehydrogenase (LDH) assay evaluated cytotoxicity...
February 27, 2024: Tissue & Cell
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