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https://www.readbyqxmd.com/read/28721171/response-to-an-unusual-outbreak-in-a-high-risk-situation
#1
Mahmood Muazu Dalhat, Olufunmilayo Ibitola Fawole, Patrick Mboya Nguku, Meeyoung Mattie Park, Casey Daniel Hall, Nasir Sani-Gwarzo
In 2010, a series of lead poisoning outbreaks linked to artisanal gold processing killed at least 400 young children in Zamfara State in northwestern Nigeria. There were several efforts to respond to the outbreaks as they occurred. Subsequent recurrence of lead poisoning outbreaks within Zamfara and beyond suggested that there were no efforts to mitigate the outbreaks as recommended for disaster management. This case study, to be completed within 3 hours, is suitable for senior level public health officials and those training for such positions...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28718616/photo-thermally-driven-refreshable-microactuators-based-on-graphene-oxide-doped-paraffin
#2
Sichao Hou, Miao Wang, Shouwu Guo, Ming Su
Actuators based on phase change materials (paraffin) can simultaneously produce large stroke length and large force due to thermal expansion, but the low thermal conductivity of paraffin requires high power input and long actuation time. The graphene oxide (GO) doped paraffin dynamic actuator addresses the key challenges in the design of thermal phase change actuators: Thermal conductivity and light absorbing is increased and the response time is reduced compared to the standard phase change actuator designed with metal heating resistors...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718257/risk-factors-for-heat-related-deaths-during-the-june-2015-heat-wave-in-karachi-pakistan
#3
Syed Ghazanfar Saleem, Tehreem Ansari, Ashraf Shamshad Ali, Sara Fatima, Mariam Hassan Rizvi, Muhammad Abdul Samad
BACKGROUND: Mortality as a consequence of heat related illness is a public health concern. Emergency department (ED) experiences increased patients' flow and decreased survival as a consequence of heat stroke during the episodes of heat wave. The present study was conducted to identify the risk factors for mortality among victims of heat wave (17th - 23rd June), 2015 evaluated in the Emergency Department of The Indus Hospital (TIH), Karachi. METHODS: In this cross-sectional study data was retrospectively collected...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28699024/transcriptome-sequencing-reveals-astrocytes-as-a-therapeutic-target-in-heat-stroke
#4
Bing Niu, Tao Zhang, Huaiqiang Hu, Bingzhen Cao
Heat-stroke is a serious form of hyperthermia with high mortality, and can induce severe central nervous system disorders. The neurovascular unit (NVU), which consists of vascular cells, glial cells, and neurons, controls blood-brain barrier (BBB) permeability and cerebral blood flow, and maintains the proper functioning of neuronal circuits. However, the detailed function of each BBB component in heat-stroke remains unknown. In order to interpret alterations caused by heat stress, we performed transcriptome comparison of neuron and astrocyte primary cultures after heat treatment...
July 11, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28680920/exertional-heat-stroke-and-the-evolution-of-field-care-a-physician-s-perspective
#5
EDITORIAL
William O Roberts
No abstract text is available yet for this article.
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28677732/jnk-signaling-is-required-for-the-mip%C3%A2-1%C3%AE-%C3%A2-associated-regulation-of-kupffer-cells-in-the-heat-stroke-response
#6
Xiao-Juan Chen, Zhong-Zhi Tang, Guo-Guo Zhu, Qing Cheng, Wen-Kai Zhang, Hui-Min Li, Wei Fu, Qi-Ping Lu
Severe heat stroke (HS) consists of extreme hyperthermia with thermoregulatory failure, leading to high morbidity and mortality. Liver injury is a complication of HS that is associated with inflammatory responses and Kupffer cells (KCs), which are resident macrophages in the liver that serve as a major source of inflammatory cytokines; however, the association and the underlying mechanisms of KC functions in HS‑induced endotoxemia and inflammation require an improved understanding. The important chemokine macrophage inflammatory protein‑1α (MIP‑1α) increases inflammatory responses and the secretion of inflammatory molecules from KCs, including tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6...
July 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28663093/heat-stress-induced-neuroinflammation-and-aberration-in-monoamine-levels-in-hypothalamus-are-associated-with-temperature-dysregulation
#7
Nishant Ranjan Chauhan, Medha Kapoor, Laxmi Prabha Singh, Rajinder Kumar Gupta, Ramesh Chand Meena, Rajkumar Tulsawani, Sarita Nanda, Shashi Bala Singh
Heat Stress (HS) induces diverse pathophysiological changes, which include brain ischemia, oxidative stress and neuronal damage. The present study was undertaken with the objective to ascertain whether neuroinflammation in Hypothalamus (HTH) caused under HS affects monoamine levels and hence, its physiological role in thermoregulation. Rats were exposed to HS in a heat simulation environmental chamber (Ambient temperature, Ta=45±0.5°C and Relative Humidity, RH=30±10%) with real-time measurement of core temperature (Tc) and skin temperature (Ts)...
June 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28656249/oxidative-stress-regulates-mitogen%C3%A2-activated-protein-kinases-and-c%C3%A2-jun-activation-involved-in-heat-stress-and-lipopolysaccharide%C3%A2-induced-intestinal-epithelial-cell-apoptosis
#8
Yanan Liu, Zhenglian Wang, Weidang Xie, Zhengtao Gu, Qiulin Xu, Lei Su
Heat stress and gut‑derived endotoxinemia are common causes of multiple organ dysfunction syndrome in heat stroke patients. Evidence has demonstrated that cell apoptosis in the small intestine serves an important role in the pathogenesis of heatstroke, which leads to increased intestinal permeability to endotoxin or lipopolysaccharides (LPS) from the gut entering the circulation. However, little is known about the potential underlying mechanisms mediating heat stress combined with LPS‑induced intestinal epithelial cell apoptosis...
June 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28651196/dancing-to-death-a-case-of-heat-stroke
#9
K Nadesan, Chandra Kumari, Mohd Afiq
Heat stroke is a medical emergency which may lead to mortality unless diagnosed early and treated effectively. Heat stroke may manifest rapidly, hence making it difficult to differentiate it from other clinical causes in a collapsed victim.(1) We are presenting a case report of twelve patients who were admitted to our emergency department from a music festival held on 13-15th of March 2014. They developed complications arising from a combination of severe adverse weather condition, prolonged outdoor physical exertion due to long hours of dancing and drug-use, resulting in heat stroke...
May 4, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28641278/astragaloside-iv-alleviates-heat-induced-inflammation-by-inhibiting-endoplasmic-reticulum-stress-and-autophagy
#10
Zhiwei Dong, Jian Zhou, Ying Zhang, Yajie Chen, Zichen Yang, Guangtao Huang, Yu Chen, Zhiqiang Yuan, Yizhi Peng, Tongtong Cao
BACKGROUND: Thermal injury is the main cause of pulmonary disease in stroke after burn and can be life threatening. Heat-induced inflammation is an important factor that triggers a series of induces pathological changes. However, this mechanism underlying heat-induced inflammation in thermal inhalation injury remains unclear. Studies have revealed that astragaloside-IV (AS-IV), a natural compound extracted from Astragalus membranaceus, has protective effects in inflammatory diseases. Here, we investigated whether the protective effects of AS-IV occur because of the suppression of heat-induced endoplasmic reticulum (ER) stress and excessive autophagy Methods: AS-IV was administered to Wistar rats after thermal inhalation injury and 16HBE140-cells were treated with AS-IV...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28636607/three-dimensional-cell-shapes-and-arrangements-in-human-sweat-glands-as-revealed-by-whole-mount-immunostaining
#11
Ryuichiro Kurata, Sugiko Futaki, Itsuko Nakano, Fumitaka Fujita, Atsushi Tanemura, Hiroyuki Murota, Ichiro Katayama, Fumihiro Okada, Kiyotoshi Sekiguchi
Because sweat secretion is facilitated by mechanical contraction of sweat gland structures, understanding their structure-function relationship could lead to more effective treatments for patients with sweat gland disorders such as heat stroke. Conventional histological studies have shown that sweat glands are three-dimensionally coiled tubular structures consisting of ducts and secretory portions, although their detailed structural anatomy remains unclear. To better understand the details of the three-dimensional (3D) coiled structures of sweat glands, a whole-mount staining method was employed to visualize 3D coiled gland structures with sweat gland markers for ductal luminal, ductal basal, secretory luminal, and myoepithelial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28625272/-research-progress-in-the-multiple-organ-dysfunction-syndrome-caused-by-heat-stroke
#12
Mengmeng Yang, Yu Zhang, Yan Zhao, Hongjun Kang
Heat stroke (HS) is a life-threatening illness characterized by core body temperatures above 40 °C coupled with central nervous system (CNS) dysfunction, including delirium, convulsions, and/or coma. Its morbidity has increased dramatically in the past few decades. Multiple organ dysfunction syndrome (MODS) is not only the most serious complication of HS, but also the leading cause of deaths. Understanding the pathogenesis, characteristic and advancement pattern of MODS caused by HS will have a profound effect on the clinical treatment, research and mortality decrease...
February 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28625252/-cerebral-injury-induced-by-heat-stroke-and-the-therapeutic-effect-of-hyperbaric-oxygen-therapy
#13
Xiaoxiao Ni, Zhifeng Liu, Qiuyou Xie, Huasheng Tong, Lei Su, Ronghao Yu
With the global warming, the incidence of heat stroke was significantly higher than before. Severe heat stroke has a high mortality, high morbidity and consolidated central nervous system injury characteristics. The main features of severe heat stroke cerebral injury include cognitive impairment, delirium, convulsions and coma. Its mechanism is related with heat shock induced cerebral tissue ischemia and hypoxia, vascular dysfunction, secondary cascade inflammation and so on. Currently, the main treatment of heat stroke cerebral injury is the hypothermia therapy, dehydration for the reduction of intracranial pressure, naloxone and other cerebral protection and nutrition treatments...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28614940/-clinical-analysis-of-16-occupationally-server-heat-stroke-cases
#14
D W Lin, J He, Z C Wu
No abstract text is available yet for this article.
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28610960/no-difference-between-noxious-and-innocuous-thermal-stimulation-on-motor-recovery-of-upper-extremity-in-patients%C3%A2-with-acute-stroke-a-randomized-controlled-trial-with%C3%A2-6-month-follow-up
#15
Roxane Lin, Miao-Ju Hsu, Ruey-Tay Lin, Mao-Hsiung Huang, Chia-Lin Koh, Ching-Lin Hsieh, Jau-Hong Lin
BACKGROUND: Thermal stimulation (TS) has been developed and incorporated into stroke rehabilitation. However, whether noxious and innocuous TS induce the same effects on motor function recovery after stroke is still unknown. A comparative study of different temperature combination regimens is needed. OBJECTIVE: To compare the short- and long-term effectiveness between noxious and innocuous TS on motor recovery of upper extremity in patients with acute stroke. DESIGN: Randomized, controlled trial with concealed allocation, intention-to-treat analysis and blinded outcome assessors...
June 10, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28602832/fumarate-decreases-edema-volume-and-improves-functional-outcome-after-experimental-stroke
#16
Bettina Hjelm Clausen, Louise Lundberg, Minna Yli-Karjanmaa, Nellie Anne Martin, Martina Svensson, Maria Zeiler Alfsen, Simon Bertram Flæng, Kristina Lyngsø, Antonio Boza-Serrano, Helle H Nielsen, Pernille B Hansen, Bente Finsen, Tomas Deierborg, Zsolt Illes, Kate Lykke Lambertsen
BACKGROUND: Oxidative stress and inflammation exacerbate tissue damage in the brain after ischemic stroke. Dimethyl-fumarate (DMF) and its metabolite monomethyl-fumarate (MMF) are known to stimulate anti-oxidant pathways and modulate inflammatory responses. Considering these dual effects of fumarates, we examined the effect of MMF treatment after ischemic stroke in mice. METHODS: Permanent middle cerebral artery occlusion (pMCAO) was performed using adult, male C57BL/6 mice...
June 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28600978/long-term-effects-of-total-and-source-specific-particulate-air-pollution-on-incident-cardiovascular-disease-in-gothenburg-sweden
#17
Leo Stockfelt, Eva M Andersson, Peter Molnár, Lars Gidhagen, David Segersson, Annika Rosengren, Lars Barregard, Gerd Sallsten
BACKGROUND AND AIMS: Long-term exposure to air pollution increases cardiopulmonary morbidity and mortality, but it is not clear which components of air pollution are the most harmful, nor which time window of exposure is most relevant. Further studies at low exposure levels have also been called for. We analyzed two Swedish cohorts to investigate the effects of total and source-specific particulate matter (PM) on incident cardiovascular disease for different time windows of exposure. METHODS: Two cohorts initially recruited to study predictors of cardiovascular disease (the PPS cohort and the GOT-MONICA cohort) were followed from 1990 to 2011...
June 7, 2017: Environmental Research
https://www.readbyqxmd.com/read/28599264/time-series-analysis-of-heat-waves-and-emergency-department-visits-in-atlanta-1993-to-2012
#18
(no author information available yet)
BACKGROUND: Heat waves are extreme weather events that have been associated with adverse health outcomes. However, there is limited knowledge of heat waves' impact on population morbidity, such as emergency department (ED) visits. OBJECTIVES: We investigated associations between heat waves and ED visits for 17 outcomes in Atlanta over a 20-year period, 1993-2012. METHODS: Associations were estimated using Poisson log-linear models controlling for continuous air temperature, dew-point temperature, day of week, holidays, and time trends...
May 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28596269/pre-treatment-with-indomethacin-results-in-increased-heat-stroke-severity-during-recovery-in-a-rodent-model-of-heat-stroke
#19
Gerald N Audet, Shauna M Dineen, Delisha A Stewart, Mark L Plamper, Wimal W Pathmasiri, Susan L McRitchie, Susan J Sumner, Lisa R Leon
There is little information on which medications may increase heat stroke(HS) susceptibility/severity. We investigated whether the Non-steroidal anti-inflammatory drug(NSAID) indomethacin(INDO) increases HS severity in a rodent model. Core temperature(Tc) of male, C57BL/6J mice(N= 45) was monitored continuously and mice were given a dose of INDO(low (LO) dose 1mg/kg or high (HI) dose 5mg/kg in flavored treat) or vehicle(flavored treat) prior to heating. HS animals were heated to 42.4°C and sacrificed at three time points for histological, molecular, and metabolic analysis: onset of HS(maximal core temperature, Tc,Max), 3 hours of recovery(minimal core temperature or hypothermia depth, HYPO), and 24 hours of recovery(24hrs)...
June 8, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28593454/permanent-cerebellar-degeneration-after-acute-hyperthermia-with-non-toxic-lithium-levels-a-case-report-and-review-of-literature
#20
REVIEW
Fabian H Rossi, Elisa Marie Rossi, Michael Hoffmann, Welwin Liu, Ramon Rodriguez Cruz, Natasha Antonovich, Arash Rezaei, Elizabeth Gonzalez, Maria Clara Franco, Alvaro Estevez, Florian Thomas
This was a study of a 33-year-old man with bipolar disorder treated with lithium who developed cerebellar atrophy after an event of extreme hyperthermia. Unlike previously reported cases of acute cerebellar atrophy after heat stroke, neuroleptic syndrome or lithium toxicity, this case was characterized by a chronic cerebellar atrophy that developed after sepsis-induced hyperthermia in the setting of non-toxic lithium levels. Unique to this case also was the early finding of cerebellar atrophy on MRI 2 weeks after the episode of hyperthermia, long-term neurotoxicity after the novo lithium therapy, and longest follow-up case of chronic cerebellar syndrome after hyperthermia with non-toxic lithium levels...
June 8, 2017: Cerebellum
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