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https://www.readbyqxmd.com/read/28625272/-research-progress-in-the-multiple-organ-dysfunction-syndrome-caused-by-heat-stroke
#1
Mengmeng Yang, Yu Zhang, Yan Zhao, Hongjun Kang
Heat stroke (HS) is a life-threatening illness characterized by core body temperatures above 40 °C coupled with central nervous system (CNS) dysfunction, including delirium, convulsions, and/or coma. Its morbidity has increased dramatically in the past few decades. Multiple organ dysfunction syndrome (MODS) is not only the most serious complication of HS, but also the leading cause of deaths. Understanding the pathogenesis, characteristic and advancement pattern of MODS caused by HS will have a profound effect on the clinical treatment, research and mortality decrease...
February 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28625252/-cerebral-injury-induced-by-heat-stroke-and-the-therapeutic-effect-of-hyperbaric-oxygen-therapy
#2
Xiaoxiao Ni, Zhifeng Liu, Qiuyou Xie, Huasheng Tong, Lei Su, Ronghao Yu
With the global warming, the incidence of heat stroke was significantly higher than before. Severe heat stroke has a high mortality, high morbidity and consolidated central nervous system injury characteristics. The main features of severe heat stroke cerebral injury include cognitive impairment, delirium, convulsions and coma. Its mechanism is related with heat shock induced cerebral tissue ischemia and hypoxia, vascular dysfunction, secondary cascade inflammation and so on. Currently, the main treatment of heat stroke cerebral injury is the hypothermia therapy, dehydration for the reduction of intracranial pressure, naloxone and other cerebral protection and nutrition treatments...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28614940/-clinical-analysis-of-16-occupationally-server-heat-stroke-cases
#3
D W Lin, J He, Z C Wu
No abstract text is available yet for this article.
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28610960/no-difference-between-noxious-and-innocuous-thermal-stimulation-on-motor-recovery-of-upper-extremity-in-patients-with-acute-stroke-a-randomized-controlled-trial-with-6-month-follow-up
#4
Roxane Lin, Miao-Ju Hsu, Ruey-Tay Lin, Mao-Hsiung Huang, Chia-Lin Koh, Ching-Lin Hsieh, Jau-Hong Lin
BACKGROUND: Thermal stimulation (TS) have been developed and incorporated in stroke rehabilitation. However, whether noxious and innocuous TS induce the same effects on motor function recovery after stroke is still unknown. A comparative study of different temperature combination regimens is needed. OBJECTIVE: To compare the short and long-term effectiveness between noxious and innocuous TS on motor recovery of upper extremity in patients with acute stroke. DESIGN: Randomised, controlled trial with concealed allocation, intention-to-treat analysis and blinded outcome assessors...
June 10, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28602832/fumarate-decreases-edema-volume-and-improves-functional-outcome-after-experimental-stroke
#5
Bettina Hjelm Clausen, Louise Lundberg, Minna Yli-Karjanmaa, Nellie Anne Martin, Martina Svensson, Maria Zeiler Alfsen, Simon Bertram Flæng, Kristina Lyngsø, Antonio Boza-Serrano, Helle H Nielsen, Pernille B Hansen, Bente Finsen, Tomas Deierborg, Zsolt Illes, Kate Lykke Lambertsen
BACKGROUND: Oxidative stress and inflammation exacerbate tissue damage in the brain after ischemic stroke. Dimethyl-fumarate (DMF) and its metabolite monomethyl-fumarate (MMF) are known to stimulate anti-oxidant pathways and modulate inflammatory responses. Considering these dual effects of fumarates, we examined the effect of MMF treatment after ischemic stroke in mice. METHODS: Permanent middle cerebral artery occlusion (pMCAO) was performed using adult, male C57BL/6 mice...
June 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28600978/long-term-effects-of-total-and-source-specific-particulate-air-pollution-on-incident-cardiovascular-disease-in-gothenburg-sweden
#6
Leo Stockfelt, Eva M Andersson, Peter Molnár, Lars Gidhagen, David Segersson, Annika Rosengren, Lars Barregard, Gerd Sallsten
BACKGROUND AND AIMS: Long-term exposure to air pollution increases cardiopulmonary morbidity and mortality, but it is not clear which components of air pollution are the most harmful, nor which time window of exposure is most relevant. Further studies at low exposure levels have also been called for. We analyzed two Swedish cohorts to investigate the effects of total and source-specific particulate matter (PM) on incident cardiovascular disease for different time windows of exposure. METHODS: Two cohorts initially recruited to study predictors of cardiovascular disease (the PPS cohort and the GOT-MONICA cohort) were followed from 1990 to 2011...
June 7, 2017: Environmental Research
https://www.readbyqxmd.com/read/28599264/time-series-analysis-of-heat-waves-and-emergency-department-visits-in-atlanta-1993-to-2012
#7
(no author information available yet)
BACKGROUND: Heat waves are extreme weather events that have been associated with adverse health outcomes. However, there is limited knowledge of heat waves' impact on population morbidity, such as emergency department (ED) visits. OBJECTIVES: We investigated associations between heat waves and ED visits for 17 outcomes in Atlanta over a 20-year period, 1993-2012. METHODS: Associations were estimated using Poisson log-linear models controlling for continuous air temperature, dew-point temperature, day of week, holidays, and time trends...
May 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28596269/pre-treatment-with-indomethacin-results-in-increased-heat-stroke-severity-during-recovery-in-a-rodent-model-of-heat-stroke
#8
Gerald N Audet, Shauna M Dineen, Delisha A Stewart, Mark L Plamper, Wimal W Pathmasiri, Susan L McRitchie, Susan J Sumner, Lisa R Leon
There is little information on which medications may increase heat stroke(HS) susceptibility/severity. We investigated whether the Non-steroidal anti-inflammatory drug(NSAID) indomethacin(INDO) increases HS severity in a rodent model. Core temperature(Tc) of male, C57BL/6J mice(N= 45) was monitored continuously and mice were given a dose of INDO(low (LO) dose 1mg/kg or high (HI) dose 5mg/kg in flavored treat) or vehicle(flavored treat) prior to heating. HS animals were heated to 42.4°C and sacrificed at three time points for histological, molecular, and metabolic analysis: onset of HS(maximal core temperature, Tc,Max), 3 hours of recovery(minimal core temperature or hypothermia depth, HYPO), and 24 hours of recovery(24hrs)...
June 8, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28593454/permanent-cerebellar-degeneration-after-acute-hyperthermia-with-non-toxic-lithium-levels-a-case-report-and-review-of-literature
#9
REVIEW
Fabian H Rossi, Elisa Marie Rossi, Michael Hoffmann, Welwin Liu, Ramon Rodriguez Cruz, Natasha Antonovich, Arash Rezaei, Elizabeth Gonzalez, Maria Clara Franco, Alvaro Estevez, Florian Thomas
This was a study of a 33-year-old man with bipolar disorder treated with lithium who developed cerebellar atrophy after an event of extreme hyperthermia. Unlike previously reported cases of acute cerebellar atrophy after heat stroke, neuroleptic syndrome or lithium toxicity, this case was characterized by a chronic cerebellar atrophy that developed after sepsis-induced hyperthermia in the setting of non-toxic lithium levels. Unique to this case also was the early finding of cerebellar atrophy on MRI 2 weeks after the episode of hyperthermia, long-term neurotoxicity after the novo lithium therapy, and longest follow-up case of chronic cerebellar syndrome after hyperthermia with non-toxic lithium levels...
June 8, 2017: Cerebellum
https://www.readbyqxmd.com/read/28588676/xuebijing-injection-attenuates-pulmonary-injury-by-reducing-oxidative-stress-and-proinflammatory-damage-in-rats-with-heat-stroke
#10
Yi Chen, Huasheng Tong, Zhiguo Pan, Dongxin Jiang, Xinqin Zhang, Junming Qiu, Lei Su, Minzhou Zhang
The present study aimed to investigate the protective effect of Xuebijing injection (XBJ) on lung injury in heat-stroke rats and the underlying mechanisms. In total, 54 rats were randomly assigned to non-thermal, saline vehicle and XBJ groups. The rectal temperature (Tc), mean arterial pressure (MAP) and respiratory rate (RR) of the rats were recorded. The time-point of heat stroke and the time of survival were assessed, and indicators of arterial blood gas were regularly measured from 0 to 60 min. The concentration of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-10 was also determined...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585006/studies-on-piston-bowl-geometries-using-single-blend-ratio-of-various-non-edible-oils
#11
Karthickeyan Viswanathan, Balamurugan Pasupathy
The depletion of fossil fuels and hike in crude oil prices were some of the main reasons to explore new alternatives from renewable source of energy. This work presents the impact of various bowl geometries on diesel engine with diesel and biodiesel samples. Three non-edible oils were selected, namely pumpkin seed oil, orange oil and neem oil. These oils were converted into respective biodiesel using transesterification process in the presence of catalyst and alcohol. After transesterification process, the oils were termed as pumpkin seed oil methyl ester (PSOME), orange oil methyl ester (OME) and neem oil methyl ester (NOME), respectively...
June 5, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28558275/heat-and-mortality-for-ischemic-and-hemorrhagic-stroke-in-12-cities-of-jiangsu-province-china
#12
Lian Zhou, Kai Chen, Xiaodong Chen, Yuanshu Jing, Zongwei Ma, Jun Bi, Patrick L Kinney
BACKGROUND: Little evidence exists on the relationship between heat and subtypes of stroke mortality, especially in China. Moreover, few studies have reported the effect modification by individual characteristics on heat-related stroke mortality. In this study, we aimed to evaluate the effect of heat exposure on total, ischemic, and hemorrhagic stroke mortality and its individual modifiers in 12 cities in Jiangsu Province, China during 2009 to 2013. METHODS: We first used a distributed lag non-linear model with quasi-Poisson regression to examine the city-specific heat-related total, ischemic, and hemorrhagic stroke mortality risks at 99th percentile vs...
May 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28554097/the-effect-of-high-temperature-on-cause-specific-mortality-a-multi-county-analysis-in-china
#13
Jie Ban, Dandan Xu, Mike Z He, Qinghua Sun, Chen Chen, Wentao Wang, Pengfei Zhu, Tiantian Li
Although existing studies have linked high temperature to mortality in a small number of regions, less evidence is available on the variation in the associations between high temperature exposure and cause-specific mortality of multiple regions in China. Our study focused on the use of time series analysis to quantify the association between high temperature and different cause-specific mortalities for susceptible populations for 43 counties in China. Two-stage analyses adopting a distributed lag non-linear model (DLNM) and a meta-analysis allowed us to obtain county-specific estimates and national-scale pooled estimates of the nonlinear temperature-mortality relationship...
May 26, 2017: Environment International
https://www.readbyqxmd.com/read/28543017/heart-heat-separation
#14
Willem J van der Laarse
The human heart requires a considerable amount of energy (10 W at rest to 100 W during exercise) for basal metabolism, activation processes and work to circulate blood (heart rate × stroke volume × arterial blood pressure). This article is protected by copyright. All rights reserved.
May 25, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28538859/-climate-change-and-heat-stroke-in-children-in-the-north-of-peru
#15
César Cabezas, Arnaldo Lachira, Littner Franco, Luis Vergara, Maria L Miraval
No abstract text is available yet for this article.
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28524042/-preparation-and-application-of-cooling-bag-for-heat-stroke-in-wild-field
#16
Hailing Li, Qing Lu, Hongping Wang, Lujia Li
Cooling bag for heat stroke in wild field was invented in order to fulfill rapid cooling for heat stroke in field environment. The cooling bag is composed of the hood, the body cover (which is made up of the anterior portion, the linking, and the posterior portion), the fixed straps, the handles. The length is 200 cm, the regulative width is 60-70 cm, the folding volume is 26 cm × 20 cm × 9 cm, and the weight is 1.4 kg. There are a number of pockets for the cold sources in the hood and the body cover. Fixed straps are set in the upper, middle and lower of the bag...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28503163/different-effects-of-cold-stimulation-on-reflex-and-non-reflex-components-of-poststroke-spastic-hypertonia
#17
Sheng Li, Henry Shin, Ping Zhou, Xiaoyan Li
OBJECTIVE: To use an established biomechanical approach to quantify reflex and non-reflex responses from spastic-paretic elbow flexors in response to controlled cold and heat stimulation. METHODS: Thirteen spastic-hemiplegic stroke subjects were tested in the experiment. The spastic elbow joint was stretched into extension for 50° at two speeds (5°/s and 100°/s) in a customized apparatus. Thermal stimulation (HEAT at heat pain threshold, COLD at 0°C, or BASELINE at room temperature) was applied to the thenar eminence of the contralateral hand immediately prior to stretching for at least 30 s...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28498471/sodium-tanshinone-iia-sulfonate-improves-inflammation-aortic-endothelial-cell-apoptosis-disseminated-intravascular-coagulation-and-multiple-organ-damage-in-a-rat-heat-stroke-model
#18
Fang Chen, Huimin Li, Guoguo Zhu, Xiaojuan Chen, Zhongzhi Tang
The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43.5˚C was considered as the time of onset of HS...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28497797/suppression-of-cognitive-function-in-hyperthermia-from-the-viewpoint-of-executive-and-inhibitive-cognitive-processing
#19
Manabu Shibasaki, Mari Namba, Misaki Oshiro, Ryusuke Kakigi, Hiroki Nakata
Climate change has had a widespread impact on humans and natural systems. Heat stroke is a life-threatening condition in severe environments. The execution or inhibition of decision making is critical for survival in a hot environment. We hypothesized that, even with mild heat stress, not only executive processing, but also inhibitory processing may be impaired, and investigated the effectiveness of body cooling approaches on these processes using the Go/No-go task with electroencephalographic event-related potentials...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490769/increased-cerebral-expressions-of-mmps-cldn5-ocln-zo1-and-aqps-are-associated-with-brain-edema-following-fatal-heat-stroke
#20
Yu Du, Jing-Tao Xu, Hong-Nian Jin, Rui Zhao, Dong Zhao, Si-Hao Du, Ye Xue, Xiao-Li Xie, Qi Wang
Human brain samples were collected from 46 autopsy cases, including 23 fatal heat stroke cases and 23 age-matched controls. Nine candidate reference genes (PES1, POLR2A, IPO8, HMBS, SDHA, GAPDH, UBC, B2M, ACTB) were evaluated in the cerebral cortex of 10 forensic autopsy cases (5 heat stroke and 5 controls), using the geNorm module in qBase(plus) software. SDHA, POLR2A, IPO8 and HMBS were identified as the most stable reference genes. Using these validated reference genes, mRNA expressions of Matrix metalloproteinases (MMPs, MMP2 and MMP9), Claudin5 (CLDN5), Occludin (OCLN), Zona occludens protein-1 (ZO1) and Aquaporins (AQPs, AQP1 and AQP4) in the cerebral cortex were examined...
May 10, 2017: Scientific Reports
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