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https://www.readbyqxmd.com/read/28430550/round-table-on-malignant-hyperthermia-in-physically-active-populations-meeting-proceedings
#1
Yuri Hosokawa, Douglas J Casa, Henry Rosenberg, John F Capacchione, Emmanuel Sagui, Sheila Riazi, Luke N Belval, Patricia A Deuster, John F Jardine, Stavros A Kavouras, Elaine C Lee, Kevin C Miller, Sheila M Muldoon, Francis G O'Connor, Scott R Sailor, Nyamkhishig Sambuughin, Rebecca L Stearns, William M Adams, Robert A Huggins, Lesley W Vandermark
CONTEXT:   Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking. OBJECTIVE:   To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research...
April 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28425051/upregulation-and-phosphorylation-of-hspb1-hsp25-and-hspb5-%C3%AE-b-crystallin-after-transient-middle-cerebral-artery-occlusion-in-rats
#2
Britta Bartelt-Kirbach, Alexander Slowik, Cordian Beyer, Nikola Golenhofen
Ischemic stroke leads to cellular dysfunction, cell death, and devastating clinical outcomes. The cells of the brain react to such a cellular stress by a stress response with an upregulation of heat shock proteins resulting in activation of endogenous neuroprotective capacities. Several members of the family of small heat shock proteins (HspBs) have been shown to be neuroprotective. However, yet no systematic study examined all HspBs during cerebral ischemia. Here, we performed a comprehensive comparative study comprising all HspBs in an animal model of stroke, i...
April 20, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28415917/exercise-rehabilitation-immediately-following-ischemic-stroke-exacerbates-inflammatory-injury
#3
Fengwu Li, John T Pendy, Jessie N Ding, Changya Peng, Xiaorong Li, Jiamei Shen, Sainan Wang, Xiaokun Geng
OBJECTIVES: The rehabilitative benefits of physical exercise after stroke appear to be contingent upon exercise initiation timing. The present study assessed the hypothesis that very early post-stroke exercise would amplify cellular stress and increases expression of pro-inflammatory mediators, while exercise initiated later would limit the inflammation associated with cerebral ischemia/reperfusion injury. METHODS: Adult rats were subjected to middle cerebral artery occlusion and subsequently assigned to one of seven groups: one sham injury control group, three stroke groups subjected to exercise initiated after 6, 24 hours, or 3 days of reperfusion, and three stroke groups not subjected to exercise...
April 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28409870/comparative-efficacy-and-safety-of-anti-platelet-agents-in-cerebral-ischemic-disease-a-network-meta-analysis
#4
Da Wa, Pa Zhu, Ziwen Long
We performed this network meta-analysis (NMA) to enhance the corresponding evidence of the relative efficacy and safety of different anti-platelet agents in cerebral ischemic disease. PubMed and EMBASE were searched systematically for relevant studies. Outcomes were compared using odds ratios (ORs) and 95% credible intervals (CrI). Each agent was ranked according to the value of surface under the cumulative ranking curve (SUCRA). Publication bias was evaluated by funnel plots while consistency between direct and indirect comparison was analyzed by node splitting and heat plots...
April 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28408965/phospholipase-c-related-catalytically-inactive-protein-can-regulate-obesity-a-state-of-peripheral-inflammation
#5
REVIEW
Yosuke Yamawaki, Kana Oue, Satomi Shirawachi, Satoshi Asano, Kae Harada, Takashi Kanematsu
Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol...
February 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28407135/pro-heat-stress-as-a-potential-etiology-of-mesoamerican-and-sri-lankan-nephropathy-a-late-night-consult-with-sherlock-holmes
#6
Richard J Johnson
Epidemics of chronic kidney disease are now recognized in Central America, Mexico, India and Sri Lanka, and there is also some evidence that similar epidemics may be occurring in the USA, Thailand and elsewhere. A common denominator for each location is manually working outside in extremely hot environments. Here we review the evidence that the primary etiology may be heat stress related to repeated subclinical or clinical acute kidney injury that eventually manifests as chronic kidney disease. In some aspects, the disease may manifest as subclinical heat stroke, subclinical rhabdomyolysis or a subclinical tumor lysis syndrome...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28398927/triggering-receptor-expressed-on-myeloid-cells-2-a-novel-regulator-of-immunocyte-phenotypes-confers-neuroprotection-by-relieving-neuroinflammation
#7
Qian Zhai, Feng Li, Xiyao Chen, Ji Jia, Sisi Sun, Dandan Zhou, Lei Ma, Tao Jiang, Fuhai Bai, Lize Xiong, Qiang Wang
BACKGROUND: Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear. METHODS: Mice were subjected to middle cerebral artery occlusion for 60 min. At 3 days after reperfusion, the effects of activation and suppression of triggering receptor expressed on myeloid cells 2 on immunocyte phenotypes (n = 5), neurobehavioral scores (n = 7), infarct volumes (n = 8), and neuronal apoptosis (n = 7) were analyzed...
April 10, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28395350/variability-in-heat-strain-in-fully-encapsulated-impermeable-suits-in-different-climates-and-at-different-work-loads
#8
Emiel A DenHartog, Candace D Rubenstein, A Shawn Deaton, Cornelis Peter Bogerd
A major concern for responders to hazardous materials (HazMat) incidents is the heat strain that is caused by fully encapsulated impermeable (NFPA 1991) suits. In a research project, funded by the US Department of Defense, the thermal strain experienced when wearing these suits was studied. Forty human subjects between the ages of 25 and 50 participated in a protocol approved by the local ethical committee. Six different fully encapsulated impermeable HazMat suits were evaluated in three climates: moderate (24°C, 50% RH, 20°C WBGT), warm-wet (32°C, 60% RH, 30°C WBGT), and hot-dry (45°C, 20% RH, 37°C WBGT, 200 W m-2 radiant load) and at three walking speeds: 2...
March 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28394694/the-death-of-sir-victor-horsley-1857-1916-and-his-burial-in-amarah
#9
Nadeem Toodayan
Sir Victor Alexander Haden Horsley (1857-1916), the pioneering British neurological surgeon, passed away 100 years ago. He died young in his sixtieth year from the effects of heat stroke while serving as consulting military surgeon to the Mediterranean Expeditionary Force in Amarah, modern-day Iraq, and was buried in the now largely abandoned "Amara War Cemetery." By the time of his death in 1916, Victor Horsley had established himself as one of the most eminent innovators of modern neurological surgery. His pioneering researches in cerebral physiology earned him an early reputation in the field, and his experiences with vivisection allowed him to confidently operate on the brain and spinal cord at a time when surgical intervention of the nervous system was fraught with uncertainty...
April 10, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28380464/heat-stress-induces-intestinal-injury-through-lysosome-and-mitochondria-dependent-pathway-in-vivo-and-in-vitro
#10
Gao Yi, Li Li, Meijuan Luo, Xuan He, Zhimin Zou, Zhengtao Gu, Lei Su
Damage to the small intestine secondary to heat stroke is a major factor in heat stroke-related morbidity and mortality. However, the underlying mechanisms by which heat stroke causes small intestinal lesions and dysfunction remain unclear. To explore the pathogenesis of small intestinal tissue and epithelial cell injury, the SW480 cell heat stress model and the mice heat stroke model were established to mimic heat stroke. Morphologic changes in intestinal tissue and increased TUNEL-positive index were induced by heat stress in vivo...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28358520/update-heat-illness-active-component-u-s-armed-forces-2016
#11
(no author information available yet)
In 2016, there were 2,536 incident diagnoses of heat illness among active component service members (incidence rate: 1.96 cases per 1,000 person-years [p-yrs]). The overall crude incidence rates of heat stroke and "other heat illness" were 0.31 and 1.65 per 1,000 p-yrs, respectively. In 2016, subgroup-specific incidence rates of heat stroke were highest among males and service members aged 19 years or younger, Asian/Pacific Islanders, Marine Corps and Army members, recruit trainees, and those in combat-specific and "other" occupations...
March 2017: MSMR
https://www.readbyqxmd.com/read/28328088/evaluation-of-the-correlation-between-severity-of-acquired-idiopathic-generalized-anhidrosis-and-quality-of-life-scores
#12
Takichi Munetsugu, Tomoko Fujimoto, Takahiro Satoh, Yoshihiko Nakazato, Yuichiro Ohshima, Masato Asahina, Hiroo Yokozeki
Symptoms of acquired idiopathic generalized anhidrosis (AIGA) include heat retention and/or heat stroke due to the effects of the disorder on the perspiration ability of the whole body under thermal environmental changes or exercise. Additionally, cholinergic urticaria can also occur in these patients. AIGA has a major impact on everyday life. However, the effects of AIGA severity on the quality of life (QOL) of the patients have not been sufficiently defined. The objective of this study was to evaluate the correlation between AIGA severity and QOL...
March 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28314926/american-football-and-fatal-exertional-heat-stroke-a-case-study-of-korey-stringer
#13
Andrew Grundstein, John A Knox, Jennifer Vanos, Earl R Cooper, Douglas J Casa
On August 1, 2001, Korey Stringer, a Pro Bowl offensive tackle for the Minnesota Vikings, became the first and to date the only professional American football player to die from exertional heat stroke (EHS). The death helped raise awareness of the dangers of exertional heat illnesses in athletes and prompted the development of heat safety policies at the professional, collegiate, and interscholastic levels. Despite the public awareness of this death, no published study has examined in detail the circumstances surrounding Stringer's fatal EHS...
March 17, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28291783/oesophageal-heat-exchangers-with-a-diameter-of-11mm-or-14-7mm-are-equally-effective-and-safe-for-targeted-temperature-management
#14
Daniel C Schroeder, Maria Guschlbauer, Alexandra C Maul, Daniel A Cremer, Ingrid Becker, David de la Puente Bethencourt, Peter Paal, Stephan A Padosch, Wolfgang A Wetsch, Thorsten Annecke, Bernd W Böttiger, Anja Sterner-Kock, Holger Herff
BACKGROUND: Targeted temperature management (TTM) is widely used in critical care settings for conditions including hepatic encephalopathy, hypoxic ischemic encephalopathy, meningitis, myocardial infarction, paediatric cardiac arrest, spinal cord injury, traumatic brain injury, ischemic stroke and sepsis. Furthermore, TTM is a key treatment for patients after out-of-hospital cardiac-arrest (OHCA). However, the optimal cooling method, which is quick, safe and cost-effective still remains controversial...
2017: PloS One
https://www.readbyqxmd.com/read/28285429/hypothermia-decreased-the-expression-of-heat-shock-proteins-in-neonatal-rat-model-of-hypoxic-ischemic-encephalopathy
#15
Byong Sop Lee, Euiseok Jung, Yeonjoo Lee, Sung-Hoon Chung
Hypothermia (HT) is a well-established neuroprotective strategy against neonatal hypoxic ischemic encephalopathy (HIE). The overexpression of heat shock proteins (HSP) has been shown to provide neuroprotection in animal models of stroke. We aimed to investigate the effect of HT on HSP70 and HSP27 expression in a neonatal rat model of HIE. Seven-day-old rat pups were exposed to hypoxia for 90 min to establish the Rice-Vannucci model and were assigned to the following four groups: hypoxic injury (HI)-normothermia (NT, 36 °C), HI-HT (30 °C), sham-NT, and sham-HT...
March 11, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28268308/wearable-deep-body-thermometers-and-their-uses-in-continuous-monitoring-for-daily-healthcare
#16
Ming Huang, Toshiyo Tamura, Takumi Yoshimura, Tadahiro Tsuchikawa, Shigehiko Kanaya
This paper introduces noninvasive deep body thermometers suitable for continuous deep body temperature (DBT) measurement. On the basis of their features, they were used in DBT monitoring for daily healthcare. A thermometer based on the dual-heat-flux method (T_DHFM), and an aural canal thermistor (ACT), were used in two studies of daily healthcare. The medical device CoreTemp by Terumo, based on the zero-heat-flux method, was also used for a DBT reference. The first study focused on preventing heat stroke in a high-temperature and high-humidity environment, while the other focused on the temperature monitoring of patients with spinal cord injuries...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265014/recast-remote-ischemic-conditioning-after-stroke-trial-a-pilot-randomized-placebo-controlled-phase-ii-trial-in-acute-ischemic-stroke
#17
Timothy J England, Amanda Hedstrom, Saoirse O'Sullivan, Richard Donnelly, David A Barrett, Sarir Sarmad, Nikola Sprigg, Philip M Bath
BACKGROUND AND PURPOSE: Repeated episodes of limb ischemia and reperfusion (remote ischemic conditioning [RIC]) may improve outcome after acute stroke. METHODS: We performed a pilot blinded placebo-controlled trial in patients with acute ischemic stroke, randomized 1:1 to receive 4 cycles of RIC within 24 hours of ictus. The primary outcome was tolerability and feasibility. Secondary outcomes included safety, clinical efficacy (day 90), putative biomarkers (pre- and post-intervention, day 4), and exploratory hemodynamic measures...
March 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28257891/combined-metabolic-and-transcriptional-profiling-identifies-pentose-phosphate-pathway-activation-by-hsp27-phosphorylation-during-cerebral-ischemia
#18
Taichiro Imahori, Kohkichi Hosoda, Tomoaki Nakai, Yusuke Yamamoto, Yasuhiro Irino, Masakazu Shinohara, Naoko Sato, Takashi Sasayama, Kazuhiro Tanaka, Hiroaki Nagashima, Masaaki Kohta, Eiji Kohmura
The metabolic pathophysiology underlying ischemic stroke remains poorly understood. To gain insight into these mechanisms, we performed a comparative metabolic and transcriptional analysis of the effects of cerebral ischemia on the metabolism of the cerebral cortex using middle cerebral artery occlusion (MCAO) rat model. Metabolic profiling by gas-chromatography/mass-spectrometry analysis showed clear separation between the ischemia and control group. The decreases of fructose 6-phosphate and ribulose 5-phosphate suggested enhancement of the pentose phosphate pathway (PPP) during cerebral ischemia (120-min MCAO) without reperfusion...
March 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28252576/apoa5-gene-polymorphisms-and-cardiovascular-diseases-metaprediction-in-global-populations
#19
Yen-Chun Lin, Veronica Nunez, Robin Johns, S Pamela K Shiao
BACKGROUND: Apolipoprotein A5 (APOA5) 1131 is one of the most investigated gene polymorphisms in association with cardiovascular diseases (CVD) for its roles in epigenetics pathways. OBJECTIVES: The major objective of this metaprediction study was to comprehensively examine the association of polymorphism risk subtypes of APOA5 1131 gene and potential contributing factors of CVD risks in global populations. METHODS: This study is a meta-analysis to determine APOA5 gene polymorphisms as risk factors for CVDs...
March 2017: Nursing Research
https://www.readbyqxmd.com/read/28237841/relationship-between-serum-anti-heat-shock-protein-27-antibody-levels-and-obesity
#20
Mehrdad Kargari, Samira Tavassoli, Amir Avan, Mahmoud Ebrahimi, Mahmoud Reza Azarpazhooh, Rasool Asoodeh, Mohsen Nematy, Seyed Mahdi Hassanian, Farzad Rahmani, Elham Mohammadzade, Habibollah Esmaeili, Mohsen Moohebati, Gordon A Ferns, Majid Ghayour-Mobarhan, Seyed Mohammad Reza Parizadeh
BACKGROUND: Heat shock protein 27 (HSP27) is an intracellular molecular chaperone that is expressed at high levels following the exposure of cells to environmental stressors such as heat, toxins, and free radicals. High levels of HSP antigens and antibody titers have been reported in several conditions including cardiovascular disease and cancers. We measured serum anti-HSP27 antibody levels in 993 subjects and assessed the associations between serum anti-HSP27 antibody levels and demographic characteristics including coronary risk factors...
February 22, 2017: Clinical Biochemistry
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