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https://www.readbyqxmd.com/read/28097803/regulation-of-mrna-following-brain-ischemia-and-reperfusion
#1
REVIEW
Donald J DeGracia
There is growing appreciation that mRNA regulation plays important roles in disease and injury. mRNA regulation and ribonomics occur in brain ischemia and reperfusion (I/R) following stroke and cardiac arrest and resuscitation. It was recognized over 40 years ago that translation arrest (TA) accompanies brain I/R and is now recognized as part of the intrinsic stress responses triggered in neurons. However, neuron death correlates to a prolonged TA in cells fated to undergo delayed neuronal death (DND). Dysfunction of mRNA regulatory processes in cells fated to DND prevents them from translating stress-induced mRNAs such as heat shock proteins...
January 17, 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/28092640/a-tale-of-two-heat-strokes-a-comparative-case-study-erratum
#2
Rebecca L Stearns, Douglas J Casa, Francis G O'Connor, Rebecca M Lopez
No abstract text is available yet for this article.
May 2016: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28073852/heat-maps-of-hypertension-diabetes-mellitus-and-smoking-in-the-continental-united-states
#3
Matthew Shane Loop, George Howard, Gustavo de Los Campos, Mohammad Z Al-Hamdan, Monika M Safford, Emily B Levitan, Leslie A McClure
BACKGROUND: Geographic variations in cardiovascular mortality are substantial, but descriptions of geographic variations in major cardiovascular risk factors have relied on data aggregated to counties. Herein, we provide the first description of geographic variation in the prevalence of hypertension, diabetes mellitus, and smoking within and across US counties. METHODS AND RESULTS: We conducted a cross-sectional analysis of baseline risk factor measurements and latitude/longitude of participant residence collected from 2003 to 2007 in the REGARDS study (Reasons for Geographic and Racial Differences in Stroke)...
January 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28071000/chemical-composition-and-antioxidant-activities-of-essential-oils-from-different-parts-of-the-oregano
#4
Fei Han, Guang-Qiang Ma, Ming Yang, Li Yan, Wei Xiong, Ji-Cheng Shu, Zhi-Dong Zhao, Han-Lin Xu
This research was undertaken in order to characterize the chemical compositions and evaluate the antioxidant activities of essential oils obtained from different parts of the Origanum vulgare L. It is a medicinal plant used in traditional Chinese medicine for the treatment of heat stroke, fever, vomiting, acute gastroenteritis, and respiratory disorders. The chemical compositions of the three essential oils from different parts of the oregano (leaves-flowers, stems, and roots) were identified by gas chromatography-mass spectrometry (GC-MS)...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28038454/reactive-oxygen-species-mediate-heat-stress-induced-apoptosis-via-erk-dephosphorylation-and-bcl-2-ubiquitination-in-human-umbilical-vein-endothelial-cells
#5
Li Li, Hongping Tan, Hong Yang, Feng Li, Xuan He, Zhengtao Gu, Ming Zhao, Lei Su
Heat stress can induce the mitochondrial apoptotic pathway in HUVEC cells, indicating that apoptosis may be a prominent pathological feature of heat stroke, however, little is known about the precise mechani sms involved in it. In this study, we describe the apoptotic effect of intense heat stress on HUVEC cells and our investigation of its underlying mechanisms. Treatment of cells with intense heat stress induced production of reactive oxygen species (ROS) and a concomitant increase in activation of the mitochondrial apoptotic pathway...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27981339/climate-change-heat-and-mortality-in-the-tropical-urban-area-of-san-juan-puerto-rico
#6
Pablo A Méndez-Lázaro, Cynthia M Pérez-Cardona, Ernesto Rodríguez, Odalys Martínez, Mariela Taboas, Arelis Bocanegra, Rafael Méndez-Tejeda
Extreme heat episodes are becoming more common worldwide, including in tropical areas of Australia, India, and Puerto Rico. Higher frequency, duration, and intensity of extreme heat episodes are triggering public health issues in most mid-latitude and continental cities. With urbanization, land use and land cover have affected local climate directly and indirectly encouraging the Urban Heat Island effect with potential impacts on heat-related morbidity and mortality among urban populations. However, this association is not completely understood in tropical islands such as Puerto Rico...
December 15, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27979795/differential-interstrain-susceptibility-to-vertebrobasilar-dolichoectasia-in-a-mouse-model
#7
Y-Q Zhu, H Xing, D Dai, D F Kallmes, R Kadirvel
BACKGROUND AND PURPOSE: Vetebrobasilar dolichoectasia is characterized by arterial elongation, dilation, and tortuosity and leads to high risks of ischemic stroke. Our aim was to investigate the differential susceptibility to elastase-induced vertebrobasilar dolichoectasia induction in 2 different mouse strains. MATERIALS AND METHODS: Elastase (25 mU) was injected into the cisterna magna in C57BL/6J (n = 36) and 129/SvEv (SV129) (n = 36) mice. Control animals were injected with heat-inactivated elastase (n = 12 for each strain)...
December 15, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27943148/association-between-exercise-induced-hyperthermia-and-intestinal-permeability-a-systematic-review
#8
REVIEW
Washington Pires, Christiano E Veneroso, Samuel P Wanner, Diogo A S Pacheco, Gisele C Vaz, Fabiano T Amorim, Cajsa Tonoli, Danusa D Soares, Cândido C Coimbra
BACKGROUND: Prolonged and strenuous physical exercise increases intestinal permeability, allowing luminal endotoxins to translocate through the intestinal barrier and reach the bloodstream. When recognized by the immune system, these endotoxins trigger a systemic inflammatory response that may affect physical performance and, in severe cases, induce heat stroke. However, it remains to be elucidated whether there is a relationship between the magnitude of exercise-induced hyperthermia and changes in intestinal permeability...
December 10, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27936516/neuroprotection-of-hypoxic-postconditioning-against-global-cerebral-ischemia-through-influencing-posttranslational-regulations-of-heat-shock-protein-27-in-adult-rats
#9
Lixuan Zhan, Liu Liu, Kongping Li, Baoxing Wu, Dandan Liu, Donghai Liang, Haixia Wen, Yanmei Wang, Weiwen Sun, Weiping Liao, En Xu
We previously reported that hypoxic postconditioning (HPC) ameliorated hippocampal neuronal death induced by transient global cerebral ischemia (tGCI) in adult rats. However, the mechanism of HPC-induced neuroprotection is still elusive. Notably, heat shock protein 27 (Hsp27) has recently emerged as a potent neuroprotectant in cerebral ischemia. Although its robust protective effect on stroke has been recognized, the mechanism of Hsp27-mediated neuroprotection is largely unknown. Here, we investigated the potential molecular mechanism by which HPC modulates the posttranslational regulations of Hsp27 after tGCI...
December 9, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27909226/unique-cytokine-and-chemokine-responses-to-exertional-heat-stroke-in-mice
#10
Michelle A King, Lisa R Leon, Deborah A Morse, Thomas L Clanton
In heat stroke, cytokines are believed to play important roles in multi-organ dysfunction and recovery of damaged tissue. The time course of the cytokine response is well defined in passive heat stroke (PHS), but little is known about exertional heat stroke (EHS). In this study we used a recently developed mouse EHS model to measure the responses of circulating cytokines/chemokines and cytokine gene expression in muscle. A very rapid increase in circulating IL-6 was observed at max core temperature (Tc,max) that peaked at 0...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27878491/possible-cause-of-nonlinear-tension-rise-in-activated-muscle-fiber-during-stretching
#11
P V Kochubei, S Yu Bershitsky
Tension in contracting muscle fiber under conditions of ramp stretching rapidly increases, but after reaching a critical stretch Pc sharply decreases. To find out the cause of these changes in muscle fiber tension, we stopped stretching before and after reaching Pc and left the fiber stretched for 50 msec. After rapid tension drop, the transient tension rise not accompanied by fiber stiffness increase was observed only in fibers heated to 25°C and stretched to Pc. Under other experimental conditions, this growth was absent...
November 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27874299/cooling-effectiveness-of-a-modified-cold-water-immersion-method-after-exercise-induced-hyperthermia
#12
Katherine E Luhring, Cory L Butts, Cody R Smith, Jeffrey A Bonacci, Ramon C Ylanan, Matthew S Ganio, Brendon P McDermott
CONTEXT:  Recommended treatment for exertional heat stroke includes whole-body cold-water immersion (CWI). However, remote locations or monetary or spatial restrictions can challenge the feasibility of CWI. Thus, the development of a modified, portable CWI method would allow for optimal treatment of exertional heat stroke in the presence of these challenges. OBJECTIVE:  To determine the cooling rate of modified CWI (tarp-assisted cooling with oscillation [TACO]) after exertional hyperthermia...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27869135/heat-stroke-internet-searches-can-be-a-new-heatwave-health-warning-surveillance-indicator
#13
Tiantian Li, Fan Ding, Qinghua Sun, Yi Zhang, Patrick L Kinney
The impact of major heatwave shocks on population morbidity and mortality has become an urgent public health concern. However, Current heatwave warning systems suffer from a lack of validation and an inability to provide accurate health risk warnings in a timely way. Here we conducted a correlation and linear regression analysis to test the relationship between heat stroke internet searches and heat stroke health outcomes in Shanghai, China, during the summer of 2013. We show that the resulting heatstroke index captures much of the variation in heat stroke cases and deaths...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27849463/core-temperature-in-service-members-with-and-without-traumatic-amputations-during-a-prolonged-endurance-event
#14
Anne M Andrews, Christina Deehl, Reva L Rogers, Alison L Pruziner
INTRODUCTION: Service members with traumatic amputations may be at an increased risk of elevated core body temperature, since their ability to dissipate heat may decrease with the reduction in body surface area (BSA) after injury. Elevated core temperature can impair physical performance during combat operations potentially putting the service members and their teams at risk. The purpose of this study was to compare core temperature between individuals with and without amputations during a prolonged endurance event...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27846153/look-beyond-thermoregulation-and-hydration-in-the-diagnosis-of-heat-stroke
#15
Chin Leong Lim
No abstract text is available yet for this article.
December 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27832001/scaling-the-low-shear-pulsatile-torvad-for-pediatric-heart-failure
#16
Jeffrey R Gohean, Erik R Larson, Brian H Hsi, Mark Kurusz, Richard W Smalling, Raul G Longoria
This article provides an overview of the design challenges associated with scaling the low-shear pulsatile TORVAD ventricular assist device (VAD) for treating pediatric heart failure. A cardiovascular system model was used to determine that a 15 ml stroke volume device with a maximum flow rate of 4 L/min can provide full support to pediatric patients with body surface areas between 0.6 to 1.5 m2. Low shear stress in the blood is preserved as the device is scaled down and remains at least two orders of magnitude less than continuous flow VADs...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27785365/a-bibliometric-analysis-of-exertional-heat-stroke-research-in-web-of-science
#17
Zhi Mao, Chao Liu, Shuo Chen, Zheng-Guo Zhu, Hong-Jun Kang, Fei-Hu Zhou
BACKGROUND: Exertional heat stroke is a fatal condition and remains a health problem. This paper evaluates the publication trend regarding exertional heat stroke research between 1996 and 2015 using a bibliometric method. METHOD: Articles regarding exertional heat stroke research published between 1996 and December 2015 were searched for in the SCI-EXPANDED database of Web of Science. The search results were analyzed with regard to publication year; publication quantity regarding countries/regions, and authors; citation frequency; and journal distribution...
2016: Military Medical Research
https://www.readbyqxmd.com/read/27781140/mesenchymal-stem-cell-based-treatments-for-stroke-neural-trauma-and-heat-stroke
#18
REVIEW
Yogi Chang-Yo Hsuan, Cheng-Hsien Lin, Ching-Ping Chang, Mao-Tsun Lin
BACKGROUND: Mesenchymal stem cell (MSC) transplantation has been reported to improve neurological function following neural injury. Many physiological and molecular mechanisms involving MSC therapy-related neuroprotection have been identified. METHODS: A review is presented of articles that pertain to MSC therapy and diverse brain injuries including stroke, neural trauma, and heat stroke, which were identified using an electronic search (e.g., PubMed), emphasize mechanisms of MSC therapy-related neuroprotection...
October 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27777944/phytochemical-screening-and-antinociceptive-and-antidiarrheal-activities-of-hydromethanol-and-petroleum-benzene-extract-of-microcos-paniculata-barks
#19
Rafath Ara Moushome, Mst Irin Akter, Md Abdullah Aziz
Introduction. Microcos paniculata is traditionally used for treating diarrhea, wounds, cold, fever, hepatitis, dyspepsia, and heat stroke. Objective. To investigate the qualitative phytochemical constituents of hydromethanol (HMPB) and petroleum benzene extract of Microcos paniculata barks (PBMPB) and to evaluate their antinociceptive and antidiarrheal activities. Methods. Phytochemical constituents and antinociceptive and antidiarrheal activities were determined and evaluated by different tests such as Molisch's, Fehling's, Mayer's, Wagner's, Dragendorff's, frothing, FeCl3, alkali, Pew's, and Salkowski's test, general test of glycosides, Baljet and NH4OH test, formalin-induced paw licking, acetic acid-induced writhing, tail immersion, and hot plate tests, and castor oil and MgSO4 induced diarrheal tests...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27777645/targeting-glial-mitochondrial-function-for-protection-from-cerebral-ischemia-relevance-mechanisms-and-the-role-of-micrornas
#20
REVIEW
Le Li, Creed M Stary
Astrocytes and microglia play crucial roles in the response to cerebral ischemia and are effective targets for stroke therapy in animal models. MicroRNAs (miRs) are important posttranscriptional regulators of gene expression that function by inhibiting the translation of select target genes. In astrocytes, miR expression patterns regulate mitochondrial function in response to oxidative stress via targeting of Bcl2 and heat shock protein 70 family members. Mitochondria play an active role in microglial activation, and miRs regulate the microglial neuroinflammatory response...
2016: Oxidative Medicine and Cellular Longevity
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