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https://www.readbyqxmd.com/read/28091963/pilot-test-of-survey-to-assess-dental-and-dental-hygiene-student-human-papillomavirus-related-oropharyngeal-cancer-knowledge-perceptions-and-clinical-practices
#1
Holdunn Rutkoski, Brynn Fowler, Ryan Mooney, Lisa Pappas, Barbara L Dixon, Lilliam M Pinzon, James Winkler, Deanna Kepka
This was the first study to develop and pilot test an assessment tool for the examination of human papillomavirus (HPV)-related oropharyngeal cancer (OPC) knowledge, perceptions, and clinical practices of oral health students. An interdisciplinary team developed the tool using surveys that examined this topic in other populations. The tool was then pilot tested at two different dental programs. Results from the pilot informed revisions to the final version of the tool. Of the 46 student participants, 18 were first-year dental hygiene and 28 were first-year dental students...
January 14, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28088212/ultrasensitive-detection-of-oncogenic-human-papillomavirus-in-oropharyngeal-tissue-swabs
#2
Andre Isaac, Morris Kostiuk, Han Zhang, Cameron Lindsay, Fawaz Makki, Daniel A O'Connell, Jeffrey R Harris, David W J Cote, Hadi Seikaly, Vincent L Biron
BACKGROUND: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) caused by oncogenic human papillomavirus (HPV) is rising worldwide. HPV-OPSCC is commonly diagnosed by RT-qPCR of HPV E6 and E7 oncoproteins or by p16 immunohistochemistry (IHC). Droplet digital PCR (ddPCR) has been recently reported as an ultra-sensitive and highly precise method of nucleic acid quantification for biomarker analysis. To validate the use of a minimally invasive assay for detection of oncogenic HPV based on oropharyngeal swabs using ddPCR...
January 14, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28073194/verruciform-xanthoma-of-the-penis-a-rare-benign-lesion-that-simulates-carcinoma
#3
Aldo Franco De Rose, Mattia Tosi, Guglielmo Mantica, Nataniele Piol, Carlo Toncini, Carlo Terrone
Verruciform xanthoma is a rare and benign condition predominantly affecting the oral cavity, but also skin and female anogenital mucosa. It can be flat, papular-warty or crateriform-cystic. Furthermore it can simulate HPV viral lesion such as condyloma and malignant neoplasia such as verrucous squamous cell carcinoma. An accurate diagnosis is important to avoid overtreatment, considering it is a benign lesion that does not require any radical treatment. We present an extremely rare case of a 64 year-old man with a small, slighty raised, gray reddish-dotted lesion on the left portion of the ventral side of his glans...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28060843/modeling-the-mechanisms-by-which-hiv-associated-immunosuppression-influences-hpv-persistence-at-the-oral-mucosa
#4
Meghna Verma, Samantha Erwin, Vida Abedi, Raquel Hontecillas, Stefan Hoops, Andrew Leber, Josep Bassaganya-Riera, Stanca M Ciupe
Human immunodeficiency virus (HIV)-infected patients are at an increased risk of co-infection with human papilloma virus (HPV), and subsequent malignancies such as oral cancer. To determine the role of HIV-associated immune suppression on HPV persistence and pathogenesis, and to investigate the mechanisms underlying the modulation of HPV infection and oral cancer by HIV, we developed a mathematical model of HIV/HPV co-infection. Our model captures known immunological and molecular features such as impaired HPV-specific effector T helper 1 (Th1) cell responses, and enhanced HPV infection due to HIV...
2017: PloS One
https://www.readbyqxmd.com/read/28053902/human-papilloma-virus-in-oral-cancer
#5
REVIEW
Soung Min Kim
Cervical cancer is the second most prevalent cancer among women, and it arises from cells that originate in the cervix uteri. Among several causes of cervical malignancies, infection with some types of human papilloma virus (HPV) is well known to be the greatest cervical cancer risk factor. Over 150 subtypes of HPV have been identified; more than 40 types of HPVs are typically transmitted through sexual contact and infect the anogenital region and oral cavity. The recently introduced vaccine for HPV infection is effective against certain subtypes of HPV that are associated with cervical cancer, genital warts, and some less common cancers, including oropharyngeal cancer...
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28043765/corrigendum-to-effect-of-hpv-on-head-and-neck-cancer-patient-survival-by-region-and-tumor-site-a-comparison-of-1362-cases-across-three-continents-oral-oncol-62-2016-20-27
#6
Gypsyamber D'Souza, Devasena Anantharaman, Tarik Gheit, Behnoush Abedi-Ardekani, Daniel C Beachler, David I Conway, Andrew F Olshan, Victor Wunsch-Filho, Tatiana N Toporcov, Wolfgang Ahrens, Kathy Wisniewski, Franco Merletti, Stefania Boccia, Eloiza H Tajara, Jose P Zevallos, José Eduardo Levi, Mark C Weissler, Sylvia Wright, Ghislaine Scelo, Angela L Mazul, Massimo Tommasino, Gabriella Cadoni, Paul Brennan
No abstract text is available yet for this article.
December 30, 2016: Oral Oncology
https://www.readbyqxmd.com/read/28039675/hpv-related-knowledge-among-dentists-and-dental-hygienists
#7
Ellen M Daley, Erika L Thompson, Cheryl A Vamos, Stacey B Griner, Coralia Vazquez-Otero, Alicia L Best, Nolan S Kline, Laura K Merrell
Dental providers, such as dentists and dental hygienists, play an important role in HPV-related oropharyngeal cancer prevention. Dental professional organizations recommend dental providers educate patients about HPV and oral cancers. The objective of this study was to assess HPV knowledge among dental providers. Dentists (n = 36) and dental hygienists (n = 146) attending a professional conference completed a continuing education post-test survey, which included socio-demographics, an HPV knowledge scale, and measure of HPV discussion with patients ("no," "yes," and "yes, but only with some patients")...
December 30, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28032082/detection-of-human-papilloma-virus-in-potentially-malignant-and-malignant-lesions-of-the-oral-cavity-and-a-study-of-associated-risk-factors
#8
B R Bijina, Junaid Ahmed, Nandita Shenoy, Ravikiran Ongole, Suchitra Shenoy, Srikala Baliga
BACKGROUND: Squamous cell carcinoma of the head and neck is the 6(th) most frequently occurring cancer worldwide, with over 400,000 cases projected annually. Multiple factors such as tobacco, alcohol, irradiation, virus, and chronic irritants are involved in the development of oral squamous cell carcinomas (OSCCs). The most important risk factors are chronic exposure to tobacco and alcohol. Although the evidence that implicates virus is increasing, particularly (human papillomavirus [HPV]), in the carcinogenesis process, the role of virus is not well established...
October 2016: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28030405/ce-human-papillomavirus-related-oral-cancers-the-nurse-s-role-in-mitigating-stigma-and-dispelling-myths
#9
Anne Katz
: The prevalence of human papillomavirus (HPV)-related oral cancers has been rising, the cancers occurring in adults at a younger age than HPV-negative oral cancers typically do and in men more often than women. Patients who are diagnosed often don't understand the disease's etiology. Because HPV is sexually transmitted, diagnosis with an HPV-related oral cancer may prompt feelings of shame, embarrassment, and guilt. There are currently three vaccines for HPV. It's essential for nurses to educate patients on HPV transmission and HPV-related oral cancer, thus helping to mitigate the stigma and dispel myths, and to promote vaccination in at-risk populations, including children and young adults...
January 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/27993131/oral-cancer-incidence-and-survival-rates-in-the-republic-of-ireland-1994-2009
#10
Hala Ali, Sarah-Jo Sinnott, Paul Corcoran, Sandra Deady, Linda Sharp, Zubair Kabir
BACKGROUND: Oral cancer is a significant public health problem world-wide and exerts high economic, social, psychological, and physical burdens on patients, their families, and on their primary care providers. We set out to describe the changing trends in incidence and survival rates of oral cancer in Ireland between 1994 and 2009. METHODS: National data on incident oral cancers [ICD 10 codes C01-C06] were obtained from the National Cancer Registry Ireland from 1994 to 2009...
December 20, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27977435/ce-human-papillomavirus-related-oral-cancers-the-nurse-s-role-in-mitigating-stigma-and-dispelling-myths
#11
Anne Katz
: Frank discussion is essential to both treatment and prevention. ABSTRACT: The prevalence of human papillomavirus (HPV)-related oral cancers has been rising, the cancers occurring in adults at a younger age than HPV-negative oral cancers typically do and in men more often than women. Patients who are diagnosed often don't understand the disease's etiology. Because HPV is sexually transmitted, diagnosis with an HPV-related oral cancer may prompt feelings of shame, embarrassment, and guilt...
December 13, 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27939577/utility-of-the-roche-cobas-4800-for-detection-of-high-risk-human-papillomavirus-in-formalin-fixed-paraffin-embedded-oropharyngeal-squamous-cell-carcinoma
#12
Jason R Pettus, Terri L Wilson, Heather B Steinmetz, Joel A Lefferts, Laura J Tafe
Clinical laboratories are expected to reliably identify human papilloma virus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) for prognostic and potential therapeutic applications. In addition to surrogate p16 immunohistochemistry (IHC) testing, DNA-based HPV-specific testing strategies are widely utilized. Recognizing the efficiency of the Roche Cobas 4800 platform for testing gynecological cytology specimens for high-risk HPV, we elected to evaluate the potential utility of this platform for testing formalin-fixed paraffin-embedded (FFPE) OPSCC tissue...
December 7, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27938996/hpv-knowledge-gaps-and-information-seeking-by-oral-cancer-patients
#13
R C Inglehart, M Taberna, R K L Pickard, M Hoff, C Fakhry, E Ozer, M Katz, M L Gillison
OBJECTIVES: The incidence of human papillomavirus (HPV) positive oral squamous cell carcinoma (OSCC) continues to increase over time, challenging healthcare providers to address their patients' HPV-related concerns. MATERIALS AND METHODS: This prospective study assessed health literacy, HPV knowledge, utilization and trust in information sources among patients with incident HPV-positive or HPV-negative OSCC diagnosed at the Ohio State University from 2011 to 2015...
December 2016: Oral Oncology
https://www.readbyqxmd.com/read/27935119/differences-in-survival-outcome-between-oropharyngeal-and-oral-cavity-squamous-cell-carcinoma-in-relation-to-hpv-status
#14
Kenneth Lai, Murray Killingsworth, Slade Matthews, Nicole Caixeiro, Carlyn Evangelista, Xiao Wu, James Wykes, Alan Samakeh, Dion Forstner, Navin Niles, Angela Hong, Cheok Soon Lee
BACKGROUND: This study examined the prognostic significance of human papillomavirus (HPV) in patients with oropharyngeal and oral cavity squamous cell carcinoma (SCC). METHODS: Tissue microarrays were constructed from oropharyngeal and oral cavity SCC (n = 143). The presence of functional HPV in tumour was determined by combined assessments of p16 immunohistochemistry and HPV in situ hybridisation. RESULTS: Oropharyngeal SCC patients presented with more advanced disease in comparison with oral cavity SCC patients (P = 0...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935070/prevalence-of-genital-oral-and-anal-hpv-infection-among-sti-patients-in-italy
#15
Giulia Ciccarese, Astrid Herzum, Alfredo Rebora, Francesco Drago
Human papillomavirus (HPV) is a carcinogenic agent responsible for tumor development in many sexually involved tissues. We present a survey on the prevalence of HPV infection in a risk population for sexually transmitted infections (STIs). The studied population was formed by 125 STI clinic attendees, who took part in a screening program on STIs. To be included in the study, the patients had to show no overt clinical signs of HPV infection. Genital (cervical in women, urethral in men), anal, and oral samples were collected with ThinPrep liquid based cytology preparation system...
December 9, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27935063/human-papillomavirus-hpv-infection-in-a-case-control-study-of-oral-squamous-cell-carcinoma-and-its-increasing-trend-in-northeastern-thailand
#16
Pensiri Phusingha, Tipaya Ekalaksananan, Patravoot Vatanasapt, Kulchaya Loyha, Supannee Promthet, Bunkerd Kongyingyoes, Natcha Patarapadungkit, Jureeporn Chuerduangphui, Chamsai Pientong
Human papillomavirus (HPV) is an independent risk factor for development of oral squamous cell carcinoma (OSCC). This study aimed to investigate the role of HPV infection and the trend in percentage of HPV-associated OSCC over a 5-year period in northeastern Thailand. In this case-control study, 91 exfoliated oral cell samples and 80 lesion cell samples from OSCC cases and exfoliated oral cells from 100 age/gender-matched controls were collected. HPV infection was investigated by PCR using GP5+/GP6+ primers followed by HPV genotyping using reverse line blot hybridization...
December 9, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27934959/hopx-functions-as-a-tumour-suppressor-in-head-and-neck-cancer
#17
Lee Fah Yap, Sook Ling Lai, Sathya Narayanan Patmanathan, Ravindran Gokulan, C Max Robinson, Joe B White, San Jiun Chai, Pathmanathan Rajadurai, Narayanan Prepageran, Yew Toong Liew, Victor Lopes, Wenbin Wei, Robert J Hollows, Paul G Murray, Daniel W Lambert, Keith D Hunter, Ian C Paterson
Head and neck squamous cell carcinoma (HNSCC) is generalized term that encompasses a diverse group of cancers that includes tumours of the oral cavity (OSCC), oropharynx (OPSCC) and nasopharynx (NPC). Genetic alterations that are common to all HNSCC types are likely to be important for squamous carcinogenesis. In this study, we have investigated the role of the homeodomain-only homeobox gene, HOPX, in the pathogenesis of HNSCC. We show that HOPX mRNA levels are reduced in OSCC and NPC cell lines and tissues and there is a general reduction of HOPX protein expression in these tumours and OPSCCs...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27930766/differences-in-the-prevalence-of-human-papillomavirus-hpv-in-head-and-neck-squamous-cell-cancers-by-sex-race-anatomic-tumor-site-and-hpv-detection-method
#18
Gypsyamber D'Souza, William H Westra, Steven J Wang, Annemieke van Zante, Alicia Wentz, Nicole Kluz, Eleni Rettig, William R Ryan, Patrick K Ha, Hyunseok Kang, Justin Bishop, Harry Quon, Ana P Kiess, Jeremy D Richmon, David W Eisele, Carole Fakhry
Importance: Human papillomavirus (HPV) causes an increasing proportion of oropharyngeal squamous cell carcinomas (OPSCCs), particularly in white men. The prevalence of HPV among other demographic groups and other anatomic sites of HNSCC is unclear. Objective: To explore the role of HPV tumor status among women and nonwhites with OPSCC and patients with nonoropharyngeal head and neck squamous cell carcinoma (non-OP HNSCC). Design, Setting, and Participants: Retrospective cohort study at 2 tertiary academic centers including cases diagnosed 1995 through 2012, oversampled for minorities and females...
December 8, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27930753/immune-response-to-hpv16-e6-and-e7-proteins-and-patient-outcomes-in-head-and-neck-cancer
#19
Heather H Nelson, Michael Pawlita, Dominique S Michaud, Michael McClean, Scott M Langevin, Melissa N Eliot, Karl T Kelsey
Importance: Pathology-based measures of human papillomavirus (HPV) status are routinely obtained in the care of head and neck cancer and are clearly associated with patient outcome for cancers of the oropharynx. However, it is unclear if HPV status is of high value for cancers of the larynx and oral cavity. In addition, it is possible to assess HPV infection using serology-based methods; however, the suitability of this pathology-independent measure for predicting patient outcome in head and neck cancer is unknown...
December 8, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27913065/hpv-status-cancer-stem-cell-marker-expression-hypoxia-gene-signatures-and-tumour-volume-identify-good-prognosis-subgroups-in-patients-with-hnscc-after-primary-radiochemotherapy-a-multicentre-retrospective-study-of-the-german-cancer-consortium-radiation-oncology
#20
Annett Linge, Fabian Lohaus, Steffen Löck, Alexander Nowak, Volker Gudziol, Chiara Valentini, Cläre von Neubeck, Martin Jütz, Inge Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Stephanie E Combs, David Mönnich, Daniel Zips, Frank Buchholz, Daniela E Aust, Gustavo B Baretton, Howard D Thames, Anna Dubrovska, Jan Alsner, Jens Overgaard, Mechthild Krause, Michael Baumann
OBJECTIVE: To investigate the impact of the tumour volume, HPV status, cancer stem cell (CSC) marker expression and hypoxia gene signatures, as potential markers of radiobiological mechanisms of radioresistance, in a contemporary cohort of patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received primary radiochemotherapy (RCTx). MATERIALS AND METHODS: For 158 patients with locally advanced HNSCC of the oral cavity, oropharynx or hypopharynx who were treated at six DKTK partner sites, the impact of tumour volume, HPV DNA, p16 overexpression, p53 expression, CSC marker expression and hypoxia-associated gene signatures on outcome of primary RCTx was retrospectively analyzed...
December 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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