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https://www.readbyqxmd.com/read/28329527/acitretin-for-the-treatment-of-recalcitrant-plantar-warts
#1
Deep Joshipura, Ari Goldminz, Jacqueline Greb, Alice Gottlieb
Plantar warts caused by human papilloma virus (HPV)may be challenging to treat when conventionalmodalities fail. We report a case of severely recalcitrantplantar warts, successfully treated with oral acitretinand topical 40% urea cream.
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329525/oral-inverted-ductal-papilloma-not-related-to-hpv
#2
Alan Motta Do Canto, Florence Zumbaio Mistro, Sergio Kignel, Fabiana Martins, Michelle Palmieri, Paulo Henrique Braz-Silva
Oral inverted ductal papilloma (OIDP) is a rare, nonrecurrent,benign lesion of salivary glands. The etiologyis still poorly understood; the correlation with humanpapilloma virus (HPV) is controversial. Herein wepresent a 74-year-old man with a tumor in lower lip.Incisional biopsy was performed and the histologicaldiagnosis was OIDP. Inno-LiPA assay, based onpolymerase chain reaction and in situ hybridizationwas used to assess for HPV with no detection of viralDNA. Surgical excision was performed without anyrecurrences after two years of follow-up...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28324192/the-presence-of-human-papillomavirus-hpv-in-placenta-and-or-cord-blood-might-result-in-th2-polarization
#3
H-M Koskimaa, A Paaso, M J P Welters, S Grénman, K Syrjänen, S H van der Burg, S Syrjänen
The purpose of this study was to evaluate if an early exposure to human papillomavirus (HPV) during the prenatal period or infancy could result in HPV16-specific T helper (Th) responses resembling those of adults with HPV-induced lesions. We tested HPV16-specific cell-mediated immunity (CMI) in children born with HPV-positive umbilical cord blood and/or placenta or having persistent oral HPV infection and in constantly oral HPV-negative controls. Peripheral blood mononuclear cells from 33 children from the Finnish HPV Family Study cohort (mean age 14...
March 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28324180/lateral-pharyngotomy-approach-in-the-treatment-of-oropharyngeal-carcinoma
#4
Andy Bertolin, Guido Ghirardo, Marco Lionello, Luciano Giacomelli, Marco Lucioni, Giuseppe Rizzotto
Surgery for early-intermediate oropharyngeal squamous cell carcinoma (OPSCC) may involve using transoral endoscopic approaches or open surgical procedures. "Lateral pharyngotomy" (LP) is an open surgical approach that improves exposure of the oropharyngeal region, while avoiding mandibulotomy. The aim of the present study was to retrospectively analyze our experience with the surgical treatment of early-intermediate OPSCC using the LP approach, and to investigate the potentially prognostic clinical and/or pathological factors that might identify patients at higher risk of recurrence after primary surgery...
March 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28316084/sensitivity-and-specificity-of-antibodies-against-hpv16-e6-and-other-early-proteins-for-the-detection-of-hpv16-driven-oropharyngeal-squamous-cell-carcinoma
#5
Dana Holzinger, Gunnar Wichmann, Lorena Baboci, Angelika Michel, Daniela Höfler, Manuel Wiesenfarth, Lea Schroeder, Paolo Boscolo-Rizzo, Christel Herold-Mende, Gerhard Dyckhoff, Andreas Boehm, Annarosa Del Mistro, Franz X Bosch, Andreas Dietz, Michael Pawlita, Tim Waterboer
To determine the sensitivity and specificity of HPV16 serology as diagnostic marker for HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), 214 HNSCC patients from Germany and Italy with fresh-frozen tumor tissues and sera collected before treatment were included in this study. 120 cancer cases were from the oropharynx and 94 were from head and neck cancer regions outside the oropharynx (45 oral cavity, 12 hypopharynx and 35 larynx). Serum antibodies to early (E1, E2, E6 and E7) and late (L1) HPV16 proteins were analyzed by multiplex serology and were compared to tumor HPV RNA status as the gold standard...
March 18, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28314692/identification-of-an-atypical-etiological-head-and-neck-squamous-carcinoma-subtype-featuring-the-cpg-island-methylator-phenotype
#6
K Brennan, J L Koenig, A J Gentles, J B Sunwoo, O Gevaert
Head and neck squamous cell carcinoma (HNSCC) is broadly classified into HNSCC associated with human papilloma virus (HPV) infection, and HPV negative HNSCC, which is typically smoking-related. A subset of HPV negative HNSCCs occur in patients without smoking history, however, and these etiologically 'atypical' HNSCCs disproportionately occur in the oral cavity, and in female patients, suggesting a distinct etiology. To investigate the determinants of clinical and molecular heterogeneity, we performed unsupervised clustering to classify 528 HNSCC patients from The Cancer Genome Atlas (TCGA) into putative intrinsic subtypes based on their profiles of epigenetically (DNA methylation) deregulated genes...
March 1, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28293975/human-papillomavirus-prevalence-in-mouthwashes-of-patients-undergoing-tonsillectomy-shows-dominance-of-hpv69-without-the-corresponding-finding-in-the-tonsils
#7
Nathalie Grün, Wilbert Mbuya, Anders Ternhag, Torbjörn Ramqvist, Alexander Ahlberg, Mattias Jangard, Tina Dalianis, Lalle Hammarstedt-Nordenvall
BACKGROUND: The role of human papillomavirus (HPV) in tonsillar squamous cell carcinomas (TSCC) is of interest, since a considerable proportion of TSCC in Sweden and other Western countries is HPV positive. Nevertheless, the natural history of HPV in normal tonsils, and the progression from localized infection to pre-malignant lesion to cancer are poorly understood. The aim of this study was to investigate whether HPV types found in mouthwash samples correlated to those in tonsillar tissue from the same individuals undergoing tonsillectomy...
March 15, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28288568/deep-sequencing-of-hpv-e6-e7-genes-reveals-loss-of-genotypic-diversity-and-gain-of-clonal-dominance-in-high-grade-intraepithelial-lesions-of-the-cervix
#8
Jane Shen-Gunther, Yufeng Wang, Zhao Lai, Graham M Poage, Luis Perez, Tim H M Huang
BACKGROUND: Human papillomavirus (HPV) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital malignancies. HPV genotyping by dideoxy (Sanger) sequencing is currently the reference method of choice for clinical diagnostics. However, for samples with multiple HPV infections, genotype identification is singular and occasionally imprecise or indeterminable due to overlapping chromatograms. Our aim was to explore and compare HPV metagenomes in abnormal cervical cytology by deep sequencing for correlation with disease states...
March 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28283546/functional-association-of-oestrogen-receptors-with-hpv-infection-in-cervical-carcinogenesis
#9
REVIEW
Balaji Ramachandran
Repeated parity and usage of oral contraceptives have demonstrated an increased risk of cervical cancer (CC) in HPV-infected women. These lifestyle observations raise the likelihood that oestrogens and HPV infection might act synergistically to affect cancers of the cervix. In vivo studies have indicated the requirement of oestrogens and ERα in the development of atypical squamous metaplasia followed by cervical intraepithelial neoplasia (CIN) I, II and III. CIN II and III are precancerous cervical lesions that can progress over time to CC as an invasive carcinoma...
April 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28272002/the-possible-role-of-diabetes-in-the-etiology-of-laryngeal-cancer
#10
Roberto Menicagli, Gianni Bolla, Laura Menigcali, Anastassia Esseridou
BACKGROUND: Laryngeal cancer and oral cancer are not always correlated with genetic mutations, HPV infection, smoking, and alcohol abuse. In the absence of these risk factors, there is an increase on these cancers with a parallel increase of diabetes. The aim of this study is to verify if diabetes could be a risk factor for the laryngeal cancer. METHODS: A questionnaire was given to a group of ninety laryngectomees to verify if these patients have presented diabetes and xerostomia before surgery...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28257064/a-pilot-study-into-the-association-between-oral-health-status-and-human-papillomavirus-16-infection
#11
Charles Xiaohang Sun, Nigel Bennett, Peter Tran, Kai Dun Tang, Yenkai Lim, Ian Frazer, Lakshman Samaranayake, Chamindie Punyadeera
BACKGROUND: Over the next 20 years, oropharyngeal cancers (OPC) will represent the majority of head and neck cancers (HNCs) in the United States. It is estimated that human papillomavirus (HPV) may account for as much as 70% to 80% of OPCs in North America and in certain parts of Europe. It is hence crucial to understand the disease risk factors and natural history of oral HPV infections. We hypothesized that poor oral health (by measures such as poor oral hygiene and periodontal disease) leads to a higher degree of oral HPV-16 infections within a patient cohort from a dental school clinic...
March 1, 2017: Diagnostics
https://www.readbyqxmd.com/read/28253242/oral-cancer-risk-factors-in-new-zealand
#12
Muhammed Yakin, Ratu Osea Gavidi, Brian Cox, Alison Rich
Oral cancer constitutes the majority of head and neck cancers, which are the fifth most common malignancy worldwide, accounting for an estimated 984,430 cases in 2012. Between 2000 and 2010, there were 1,916 cases of OSCC in New Zealand with a male to female ratio of 1.85:1, and an age-standardised incidence rate of 42 persons per 1,000,000 population. This article presents an overview of the main risk factors for oral and oropharyngeal cancers and their prevalence in New Zealand. Alcohol consumption is the most prevalent risk factor in New Zealand, followed by tobacco...
March 3, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28247229/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-oropharynx
#13
William H Westra, James S Lewis
The changes for oropharyngeal lesions in the 2017 edition of the WHO/IARC Classification of Head and Neck Tumours reference book are dramatic and significant, largely due to the growing impact of high risk human papillomavirus (HPV). The upcoming edition divides tumours of the oral cavity and oropharynx into separate chapters, classifies squamous cell carcinomas (SCC) of the oropharynx on the basis of HPV status, abandons the practice of histologic grading for oropharyngeal SCCs that are HPV positive, recognizes small cell carcinoma of the oropharynx, and combines polymorphous low grade adenocarcinoma and cribriform adenocarcinoma of tongue and minor salivary glands under the single term "polymorphous adenocarcinoma...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28241096/the-prognostic-role-of-sex-race-and-human-papillomavirus-in-oropharyngeal-and-nonoropharyngeal-head-and-neck-squamous-cell-cancer
#14
Carole Fakhry, William H Westra, Steven J Wang, Annemieke van Zante, Yuehan Zhang, Eleni Rettig, Linda X Yin, William R Ryan, Patrick K Ha, Alicia Wentz, Wayne Koch, Jeremy D Richmon, David W Eisele, Gypsyamber D'Souza
BACKGROUND: Human papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers (HNSCCs)...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28239675/hpv16-e6-seropositivity-among-cancer-free-men-with-oral-anal-or-genital-hpv16-infection
#15
Daniel C Beachler, Tim Waterboer, Christine M Pierce Campbell, Donna J Ingles, Krystle A Lang Kuhs, Alan G Nyitray, Allan Hildesheim, Michael Pawlita, Aimée R Kreimer, Anna R Giuliano
Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0%-18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0%-8.8%), and 24-month persistent genital HPV16-infection (1/84; 1...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/28236455/epidemiology-of-vulvar-neoplasia-in-the-nih-aarp-study
#16
Louise A Brinton, Jake E Thistle, Linda M Liao, Britton Trabert
OBJECTIVE: To clarify risk factors for rare vulvar neoplasms. METHODS: Within the NIH-AARP Study, among 201,469 women interviewed in 1995-1996 and followed for a mean of 13.8years, there were 370 diagnoses of incident vulvar neoplasms, including 170 invasive and 198 vulvar intraepithelial neoplasms grade 3 (VIN3). Hazard ratios (HR) and 95% confidence intervals (CI) were calculated via multivariate logistic regression for various demographic, reproductive and lifestyle factors, with separate consideration of relations according to invasiveness, histology and age at diagnosis...
February 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28225785/betel-nut-chewing-oral-premalignant-lesions-and-the-oral-microbiome
#17
Brenda Y Hernandez, Xuemei Zhu, Marc T Goodman, Robert Gatewood, Paul Mendiola, Katrina Quinata, Yvette C Paulino
Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Study participants were recruited from a dental clinic in Guam. Structured interviews and oral examinations were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28218707/fkbp51-immunohistochemical-expression-a-new-prognostic-biomarker-for-oscc
#18
Daniela Russo, Francesco Merolla, Massimo Mascolo, Gennaro Ilardi, Simona Romano, Silvia Varricchio, Virginia Napolitano, Angela Celetti, Loredana Postiglione, Pier Paolo Di Lorenzo, Luigi Califano, Giovanni Orabona Dell'Aversana, Fabio Astarita, Maria Fiammetta Romano, Stefania Staibano
Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered in the clinical setting. Therapy of OSCC tumors mainly relies on surgery, radiotherapy and partially on chemotherapy; there is an urgent need for biomarkers able to better stratify OSCC patients' risk to address targeted therapeutic strategies. The role of immune response in the pathogenesis and biological behavior of OSCC has been investigated by several authors, and promising results have been obtained with immune checkpoint inhibitors...
February 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28199413/low-prevalence-of-human-papillomavirus-in-head-and-neck-squamous-cell-carcinoma-in-the-northwest-region-of-the-philippines
#19
Pia Marie Albano, Dana Holzinger, Christianne Salvador, Jose Orosa, Sheryl Racelis, Modesty Leaño, Danilo Sanchez, Lara Mae Angeles, Gordana Halec, Markus Schmitt, John Donnie Ramos, Michael Pawlita
BACKGROUND: Geographic heterogeneity of human papillomavirus (HPV) involvement in head and neck squamous cell carcinoma (HNSCC) has been observed over the last few years. This trend has not been evaluated in the Philippines. Hence, this study aims to provide for the first time a data on the prevalence of HPV in HNSCC in the northwestern region of the Philippines. METHODS: Two hundred one (201) biopsy samples (179 formalin fixed paraffin embedded and 22 fresh frozen) from 163 Filipino HNSCC cases (oral cavity = 88; larynx = 60; oropharynx = 15) diagnosed between 2003 to 2013 were initially included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28198978/high-prevalence-of-human-papillomavirus-hpv-in-oral-mucosal-lesions-of-patients-at-the-ambulatory-of-oral-diagnosis-of-the-federal-university-of-sergipe-northeastern-brazil
#20
Mariana Goveia Melo Ribeiro, Larissa Doddi Marcolino, Bruna Ribeiro de Andrade Ramos, Elaine Alves Miranda, Cleverson Luciano Trento, Sona Jain, Ricardo Queiroz Gurgel, Márcia Guimarães da Silva, Silvio Santana Dolabella
Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers...
January 2017: Journal of Applied Oral Science: Revista FOB
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