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https://www.readbyqxmd.com/read/29770611/the-changing-aetiology-of-head-and-neck-squamous-cell-cancer-a-tale-of-three-cancers
#1
Steven J Thomas, Chris M Penfold, Andrea Waylen, Andrew R Ness
Head and neck cancers are the sixth most common cancers worldwide and an important cause of ill health.(1) Each year about 9000 cases are reported in the UK.(2) Survival is poor and despite advances in treatment, has not improved until recently.(3) The majority of head and neck cancers are squamous cell carcinomas, affecting the larynx, oropharynx and oral cavity. The aetiology is changing and this has implications for prevention and treatment. Twenty years ago, tobacco and alcohol consumption were considered to be the established risk factors and it was estimated that these risk factors accounted for about 75% of cases...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29756287/racial-differences-in-the-prevalence-of-oncogenic-oral-human-papillomavirus-infection-types-in-the-united-states-adult-population
#2
Samantha Raymond, Bian Liu, Emanuela Taioli
BACKGROUND: The purpose of this study was to describe the prevalence of oral human papillomavirus (HPV) types according to race and to examine risk factors for oral HPV infection in United States adults. METHODS: Using 2009-2014 data from the National Health and Nutrition Examination Survey, 13 981 subjects were examined. Prevalence of oral HPV and individual oncogenic HPV types were described according to race. Multivariable logistic and linear regressions were used to examine the risk factors for infection and coinfection...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29753605/assessing-university-students-sexual-risk-behaviors-as-predictors-of-human-papillomavirus-hpv-vaccine-uptake-behavior
#3
Rebecca L Rohde, Eric Adjei Boakye, Kara M Christopher, Christian J Geneus, Ronald J Walker, Mark A Varvares, Nosayaba Osazuwa-Peters
OBJECTIVES: There exists a significant gap in vaccine coverage of the human papillomavirus (HPV) among college-aged students. This study assessed sexual risk-taking behavior among university students and analyzed predictors of HPV vaccine initiation and completion in this population. MATERIALS AND METHODS: Data (n = 746) were from an anonymous online, cross-sectional survey distributed to university students, between the ages of 19-26 years, at a private Midwestern university...
May 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29750853/depth-of-invasion-on-pathological-outcomes-in-clinical-low-stage-oral-tongue-cancer-patients
#4
Maheer M Masood, Douglas R Farquhar, Jessica P Vanleer, Samip N Patel, Trevor G Hackman
OBJECTIVES: Depth of invasion was added to the 8th edition American Joint Committee on Cancer guidelines for T staging of HPV-negative oral cavity squamous cell carcinoma. Our aim is to determine the impact of depth of invasion on pathological variables and outcomes in low-stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. SUBJECTS AND METHODS: All clinical T1/T2 N0 HPV negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29748906/human-papillomavirus-related-oral-cancer-knowledge-and-awareness-among-spanish-dental-students
#5
Alejandro Ismael Lorenzo-Pouso, Pilar Gándara-Vila, Cristina Banga, Mercedes Gallas, Mario Pérez-Sayáns, Abel García, Ellen M Daley, Iria Gasamáns
Human papillomavirus (HPV) infections are responsible for a significant part of the global burden of cancer. Epidemiologic studies have shown increasing trends of HPV-related oral cancers worldwide. Dental professionals need comprehensive up-to-date HPV-related information to be able to provide correct advice to their patients. The aim of this paper is to describe knowledge and awareness levels of dental students from Spain on HPV infection, HPV vaccination, oral cancer prevention, and HPV-related oropharyngeal cancer...
May 10, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29747121/generation-of-a-novel-next-generation-sequencing-based-method-for-the-isolation-of-new-human-papillomavirus-types
#6
Rosario N Brancaccio, Alexis Robitaille, Sankhadeep Dutta, Cyrille Cuenin, Daiga Santare, Girts Skenders, Marcis Leja, Nicole Fischer, Anna R Giuliano, Dana E Rollison, Adam Grundhoff, Massimo Tommasino, Tarik Gheit
With the advent of new molecular tools, the discovery of new papillomaviruses (PVs) has accelerated during the past decade, enabling the expansion of knowledge about the viral populations that inhabit the human body. Human PVs (HPVs) are etiologically linked to benign or malignant lesions of the skin and mucosa. The detection of HPV types can vary widely, depending mainly on the methodology and the quality of the biological sample. Next-generation sequencing is one of the most powerful tools, enabling the discovery of novel viruses in a wide range of biological material...
May 7, 2018: Virology
https://www.readbyqxmd.com/read/29743199/evaluation-of-dried-blood-spots-and-oral-fluids-as-alternatives-to-serum-for-human-papillomavirus-antibody-surveillance
#7
Karly S Louie, Jama Dalel, Caroline Reuter, Sara L Bissett, Michelle Kleeman, Lesley Ashdown-Barr, Rawinder Banwait, Anna Godi, Peter Sasieni, Simon Beddows
Human papillomavirus (HPV) vaccination elicits high-titer genotype-specific antibody responses that are associated with a reduced risk of cervical disease caused by vaccine-incorporated genotypes. Our objective was to evaluate dried blood spots (DBSs) and oral mucosal transudate (OMT) as alternative samples to serum to confirm HPV vaccine antibody status. A study was carried out to evaluate the feasibility of detecting HPV16 and HPV18 antibodies in OMT, DBSs, and sera among women who self-reported being unvaccinated or fully vaccinated with the HPV vaccine...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29742291/pd-1-and-pd-l1-expression-in-hnscc-primary-cancer-and-related-lymph-node-metastasis-impact-on-clinical-outcome
#8
Sven Schneider, Lorenz Kadletz, Robert Wiebringhaus, Lukas Kenner, Edgar Selzer, Thorsten Füreder, Orsolya Rajky, Anna S Berghoff, Matthias Preusser, Gregor Heiduschka
AIMS: Expression profiles and clinical impact of programmed cell death ligand 1 (PD-L1) and programmed cell death 1 (PD-1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not fully elucidated. This study evaluates expression patterns in primary HNSCC and related lymph node metastasis and impact on patients' clinical outcome. METHODS AND RESULTS: Immunohistochemical staining patterns of PD-L1 and PD-1 were evaluated in 129 specimens of primary HNSCC and 77 lymph node metastases...
May 9, 2018: Histopathology
https://www.readbyqxmd.com/read/29740440/targeting-head-and-neck-cancer-by-vaccination
#9
REVIEW
Chuan Wang, James Dickie, Ruhcha V Sutavani, Catherine Pointer, Gareth J Thomas, Natalia Savelyeva
Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29736315/kshv-co-infection-regulates-hpv16-cervical-cancer-cells-pathogenesis-in-vitro-and-in-vivo
#10
Lu Dai, Jing Qiao, Luis Del Valle, Zhiqiang Qin
High-risk human papillomavirus (HPV) infection is the etiological agent of cervical, oral and oropharyngeal cancers. Another oncogenic virus, Kaposi sarcoma-associated herpesvirus (KSHV) can cause several human cancers arising in those immunocompromised patients. KSHV DNA has been detected in the oral cavity and the female genital tract, although its detection rate in cervical samples is relatively low. Therefore, it remains unclear about the role of KSHV co-infection in the development of HPV-related neoplasia...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29735324/optimization-of-human-papillomavirus-hpv-type-16-e7-expressing-lactobacillus-based-vaccine-for-induction-of-mucosal-e7-specific-ifn%C3%AE-producing-cells
#11
Atsushi Komatsu, Shizunobu Igimi, Kei Kawana
Therapeutic HPV vaccine is an agent to induce E7-specific Th1 immune responses to treat cervical neoplasia (CIN2-3). Our previous clinical trial has demonstrated that oral administration of HPV16 E7-expressing Lactobacillus casei (L. casei), GLBL101c, resulted in the regression of HPV16-related CIN3. Here we examined optimization of the E7-expressing L. casei for induction of the mucosal immune responses to E7. Various doses of HPV16 E7 molecule were displayed on the L. casei. Immunization with E7-bound L. casei showed the induction of E7-specific mucosal IFNγ-producing cells was dependent on displayed E7-doses but saturated beyond 0...
May 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29732937/factors-of-the-epidemiological-triad-that-influence-the-persistence-of-human-papilloma-virus-infection-in-women-with-systemic-lupus-erythematosus
#12
S Méndez-Martínez, M García-Carrasco, E A Jiménez-Herrera, C Mendoza-Pinto, I Etchegaray-Morales, P W Barahona-Rubio, J L Gálvez-Romero, P Munguía-Realpozo, C O Muñóz-Guarneros, M L Cedillo-Ramírez, S E Silva-Gómez, G Linares-Fleites, A Rojas-Vallaraga
We studied the epidemiologic triad-related factors influencing human papilloma virus (HPV) persistence in Mexican women with systemic lupus erythematosus (SLE). Patients aged ≥18 years with SLE (American College of Rheumatology criteria), with and without HPV persistence, were selected. Groups were analyzed by (1) host: clinical disease characteristics; (2) agent: (I) infectious (prevalence, incidence, HPV genotype and co-infections (≥2 HPV genotypes or mycoplasmas)), (II) chemical (contraceptives and immunosuppressive drugs) and (III) physical (vitamin D deficiency) and (3) environment...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29720524/high-rate-of-infection-by-only-oncogenic-human-papillomavirus-in-amerindians
#13
Daniela Vargas-Robles, Magda Magris, Natalia Morales, Maurits N C de Koning, Iveth Rodríguez, Tahidid Nieves, Filipa Godoy-Vitorino, Gloria I Sánchez, Luis David Alcaraz, Larry J Forney, María-Eglée Pérez, Luis García-Briceño, Leen-Jan van Doorn, María Gloria Domínguez-Bello
Human papillomavirus (HPV), an etiological agent of cervical cancer (CC), has infected humans since ancient times. Amerindians are the furthest migrants out of Africa, and they reached the Americas more than 14,000 years ago. Some groups still remain isolated, and some migrate to towns, forming a gradient spanning urbanization. We hypothesized that, by virtue of their history, lifestyle, and isolation from the global society, remote Amerindian women have lower HPV diversity than do urban women (Amerindian or mestizo)...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29708483/sexual-behaviour-hpv-status-and-p16-ink4a-expression-in-oropharyngeal-and-oral-cavity-squamous-cell-carcinomas-a-case-case-comparison-study
#14
Sarah Emmett, Samuel Boros, David C Whiteman, Sandro V Porceddu, Benedict J Panizza, Annika Antonsson
A significant proportion of mucosal squamous cell carcinomas of the head and neck (HNSCC; particularly of the oropharynx) are directly attributable to the human papillomavirus (HPV). The increase in the incidence of HPV-related tumours has been postulated to be due to changing sexual practices in the community. We analysed 136 formalin-fixed paraffin-embedded squamous cell carcinomas from the oral cavity (n=40) and oropharynx (n=96) recruited from the Princess Alexandra Hospital (Brisbane, Australia). Samples were analysed for the presence of HPV DNA using a combination of mucosal HPV general primer GP+ PCR and sequencing; p16INK4a expression was assessed by immunohistochemistry...
April 30, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29708352/-anogenital-hpv-infection-as-the-potential-risk-factor-for-oropharyngeal-carcinoma
#15
Borek Sehnal, Tomáš Podlešák, Emanuela Kmoníčková, Monika Nipčová, Daniel Driák, Jiří Sláma, Michal Zikán
BACKGROUND: Human papillomavirus (HPV) can cause cervical, other genital, anal, head, and neck cancers. The incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer most commonly caused by HPV infection, is increasing. The prevalence of oral HPV infections is considerably lower than that of genital HPV infections; however, infection of both sites is strongly associated with sexual behavior. Although the natural histories of cervical and oral HPV infections do not markedly differ, the virus seems to rarely infect oral and genital sites simultaneously...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29706018/hpv-prevalence-in-a-mid-european-oral-squamous-cell-cancer-population-a-cohort-study
#16
Daniel Dalla Torre, Doris Burtscher, Elisabeth Soelder, Vincent Offermanns, Michael Rasse, Wolfgang Puelacher
OBJECTIVES: HPV infection has been investigated intensively regarding oropharyngeal carcinoma. However, there is still lack of knowledge about the impact of oral HPV infections concerning oral squamous cell carcinoma. The present study investigates the prevalence of oral HPV infection in such patients, identifying possible differences between HPV+ and HPV- patients. SUBJECTS AND METHODS: 106 consequent patients were investigated. After completion of a study questionnaire regarding risk factors, a brush smear sample was taken in each subject to identify the individual oral HPV status (overall/low risk/high risk)...
April 29, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29702717/association-between-hormonal-contraception-and-injuries-induced-by-human-papillomavirus-in-the-uterine-cervix
#17
Lia Karina Volpato, Isabela Ribeiro Siqueira, Rodrigo Dias Nunes, Anna Paula Piovezan
OBJECTIVE:  To evaluate the association between hormonal contraception and the appearance of human papillomavirus HPV-induced lesions in the uterine cervix of patients assisted at a school outpatient clinic - ObGyn outpatient service of the Universidade do Sul de Santa Catarina. METHODS:  A case-control study, with women in fertile age, performed between 2012 and 2015. A total of 101 patients with cervical lesions secondary to HPV were included in the case group, and 101 patients with normal oncotic colpocytology, in the control group...
April 27, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29682214/head-and-neck-squamous-cell-carcinoma-and-its-correlation-with-human-papillomavirus-in-people-living-with-hiv-a-systematic-review
#18
REVIEW
Manuela Ceccarelli, Emmanuele Venanzi Rullo, Alessio Facciolà, Giordano Madeddu, Bruno Cacopardo, Rosaria Taibi, Francesco D'Aleo, Marilia Rita Pinzone, Isa Picerno, Michele di Rosa, Giuseppa Visalli, Fabrizio Condorelli, Giuseppe Nunnari, Giovanni Francesco Pellicanò
Over the last 20 years we assisted to an increase in the mean age of People Living with HIV and their comorbidities. Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. Despite their increasing incidence in HIV-positive people, mechanisms that lead to their development and progression are only partially understood. The aim of this review is to identify key data and factors about HPV-related head and neck squamous cell carcinoma in HIV-seropositive patients...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29675996/streptococcus-endopeptidases-promote-hpv-infection-in-vitro
#19
Sylvia I Pavlova, Reid V Wilkening, Michael J Federle, Yu Lu, Joel Schwartz, Lin Tao
Both cervical and throat cancers are associated with human papillomavirus (HPV). HPV infection requires cleavage of the minor capsid protein L2 by furin. While furin is present in the vaginal epithelium, it is absent in oral epithelial basal cells where HPV infection occurs. The objective of this study was to investigate whether common oral bacteria express furin-like peptidases. By screening strains representing 12 oral Streptococcus and Enterococcus species, we identified that eight Streptococcus strains displayed high levels of furin-like peptidase activity, with S...
April 19, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29673737/epidemiological-features-of-cancers-of-the-oral-cavity-oropharynx-hypopharynx-and-larynx-cancer-in-r%C3%A3-union-island
#20
A Delagranda, G Leterme, E Chirpaz, C Ferdynus, C Fernandez, F Rubin
INTRODUCTION: This study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature. MATERIAL AND METHOD: A retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island...
April 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
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