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https://www.readbyqxmd.com/read/28495149/united-states-multicenter-clinical-trial-of-corneal-collagen-crosslinking-for-keratoconus-treatment
#1
Peter S Hersh, R Doyle Stulting, David Muller, Daniel S Durrie, Rajesh K Rajpal
PURPOSE: To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of progressive keratoconus. DESIGN: Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS: Patients with progressive keratoconus (n = 205). METHODS: The treatment group underwent standard CXL and the sham control group received riboflavin alone without removal of the epithelium. MAIN OUTCOME MEASURES: The primary efficacy criterion was the change over 1 year of topography-derived maximum keratometry value, comparing treatment with control group...
May 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28486724/noncontact-quantification-of-topography-of-anterior-corneal-surface-and-bowman-s-layer-with-high-speed-oct
#2
Himanshu Matalia, Mathew Francis, Tarun Gangil, Rachana S Chandapura, Mathew Kurian, Rohit Shetty, Everette Jacob Remington Nelson, Abhijit Sinha Roy
PURPOSE: To quantify keratometry and wavefront aberration of the anterior corneal surface and epithelium-Bowman's layer interface using anterior segment optical coherence tomography (OCT). METHODS: Twenty-five normal eyes and 25 eyes with keratoconus were retrospectively analyzed. The anterior corneal edge and epithelium-Bowman's layer interface were segmented from 12 distortion-corrected OCT B-scans. Axial tangential curvatures and wavefront aberration were calculated by ray tracing and 6th order Zernike analyses...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28473428/to-show-the-efficacy-of-compressive-sutures-alone-in-the-management-of-acute-hydrops-in-a-keratoconus-patient
#3
Praveen Subudhi, Zahiruddin Khan, B Nageswar Rao Subudhi, Silla Sitaram
A 17-year-old boy presented with sudden loss of vision in the left eye (OS) for 3 days. He was diagnosed with acute hydrops following keratoconic progression in OS. The patient was initially started on topical medical therapy, including steroids and hypertonic eye drops; showing no signs of resolution. Hence, the patient was planned for full-thickness compressive corneal sutures. Four sutures were placed along the central oedematous area covering the area of ruptured Descemet's membrane. Signs of resolution were noticed by 1st week and there was complete resolution of oedema by 3rd post-op week...
May 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28470657/-morphologic-corneal-changes-after-crosslinking-for-keratoconus
#4
P L Müller, K U Löffler, M Kohlhaas, F G Holz, M C Herwig-Carl
Keratoconus is a relatively common (1 : 2000) bilateral disease leading to a change in biochemical and biomechanical corneal structure as well as thinning and ectasia. For more than 10 years, crosslinking has been a therapeutic option in cases of progression. Using riboflavin and UVA-radiation, the anterior corneal stroma (300 µm) gets stiffened by crosslinking of collagen fibers. When protocols and limitations are adhered, the procedure is described to be effective and of low-risk. This review gives an overview about physiologic and pathologic changes in keratoconic corneas before and after crosslinking...
May 3, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28458708/femtosecond-laser-arcuate-keratotomy-for-the-correction-of-postkeratoplasty-high-astigmatism-in-keratoconus
#5
Mohammad Naser Hashemian, Habib Ojaghi, Mehrdad Mohammadpour, Mahmoud Jabbarvand, Firouzeh Rahimi, Mohammad-Ali Abtahi, Mehdi Mazloumi, Seyed-Hossein Abtahi
BACKGROUND: Astigmatism is the leading complication in visual recovery after penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK); in this study, we evaluated the outcome of femtosecond laser arcuate keratotomy (FLAK) after DALK and PKP in Iranian keratoconic patients. MATERIALS AND METHODS: In this prospective interventional case series, refractive and keratometric predictability, efficacy, and complications of FLAK for postkeratoplasty astigmatism in keratoconus were evaluated; 23 eyes of 23 consecutive patients (mean age of 32...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28407167/introduction-of-two-novel-stiffness-parameters-and-interpretation-of-air-puff-induced-biomechanical-deformation-parameters-with-a-dynamic-scheimpflug-analyzer
#6
Cynthia J Roberts, Ashraf M Mahmoud, Jeffrey P Bons, Arif Hossain, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra, Renato Ambrósio
PURPOSE: To investigate two new stiffness parameters and their relationships with the dynamic corneal response (DCR) parameters and compare normal and keratoconic eyes. METHODS: Stiffness parameters are defined as Resultant Pressure at inward applanation (A1) divided by corneal displacement. Stiffness parameter A1 uses displacement between the undeformed cornea and A1 and stiffness parameter highest concavity (HC) uses displacement from A1 to maximum deflection during HC...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28393039/placido-disk-based-topography-versus-high-resolution-rotating-scheimpflug-camera-for-corneal-power-measurements-in-keratoconic-and-post-lasik-eyes-reliability-and-agreement
#7
Rachele R Penna, Ugo de Sanctis, Martina Catalano, Luca Brusasco, Federico M Grignolo
AIM: To compare the repeatability/reproducibility of measurement by high-resolution Placido disk-based topography with that of a high-resolution rotating Scheimpflug camera and assess the agreement between the two instruments in measuring corneal power in eyes with keratoconus and post-laser in situ keratomileusis (LASIK). METHODS: One eye each of 36 keratoconic patients and 20 subjects who had undergone LASIK was included in this prospective observational study...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28336058/large-9-mm-deep-anterior-lamellar-keratoplasty-with-clearance-of-a-6-mm-optical-zone-optimizes-outcomes-of-keratoconus-surgery
#8
Massimo Busin, Pia Leon, Yoav Nahum, Vincenzo Scorcia
PURPOSE: To evaluate the outcomes of a 9-mm deep anterior lamellar keratoplasty (DALK) with removal of the deep stroma limited to the central 6-mm optical zone. DESIGN: Prospective, noncomparative, interventional case series. PARTICIPANTS: A total of 80 consecutive keratoconic eyes without deep stromal scarring, with at least 1 postoperative examination 1 month after complete suture removal. INTERVENTION: A standardized DALK was performed, including (1) deep trephination of the recipient bed 450 to 550 μm in depth and 9 mm in diameter; (2) pneumatic dissection; (3) debulking of approximately 80% of the anterior stroma; (4) removal of the deep stroma (bubble roof) from a central 6-mm optical zone; and (5) transplantation of a 9-mm anterior corneal lamella cut by microkeratome-assisted dissection (400-μm head) and sutured with a double running 10-0 nylon suture...
March 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28317679/distinguishing-between-contact-lens-warpage-and-ectasia-usefulness-of-optical-coherence-tomography-epithelial-thickness%C3%A2-mapping
#9
Julie M Schallhorn, Maolong Tang, Yan Li, Derek J Louie, Winston Chamberlain, David Huang
PURPOSE: To distinguish between corneal ectasia and contact lens-related warpage by characteristic patterns on corneal topography and optical coherence tomography (OCT) epithelial thickness maps. SETTING: Casey Eye Institute, Portland, Oregon, USA. DESIGN: Prospective and retrospective case series. METHODS: Axial and mean power maps were obtained on corneal topography systems. Epithelial thickness maps were generated using RTVue OCT...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28315339/elastic-microfibril-distribution-in-the-cornea-differences-between-normal-and-keratoconic-stroma
#10
Tomas L White, Philip N Lewis, Robert D Young, Koji Kitazawa, Tsutomu Inatomi, Shigeru Kinoshita, Keith M Meek
The optical and biomechanical properties of the cornea are largely governed by the collagen-rich stroma, a layer that represents approximately 90% of the total thickness. Within the stroma, the specific arrangement of superimposed lamellae provides the tissue with tensile strength, whilst the spatial arrangement of individual collagen fibrils within the lamellae confers transparency. In keratoconus, this precise stromal arrangement is lost, resulting in ectasia and visual impairment. In the normal cornea, we previously characterised the three-dimensional arrangement of an elastic fiber network spanning the posterior stroma from limbus-to-limbus...
March 14, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28303580/synteyes-ktc-higher-order-statistical-eye-model-for-developing-keratoconus
#11
Jos J Rozema, Pablo Rodriguez, Irene Ruiz Hidalgo, Rafael Navarro, Marie-José Tassignon, Carina Koppen
PURPOSE: To present and validate a stochastic eye model for developing keratoconus to e.g. improve optical corrective strategies. This could be particularly useful for researchers that do not have access to original keratoconic data. METHODS: The Scheimpflug tomography, ocular biometry and wavefront of 145 keratoconic right eyes were collected. These data were processed using principal component analysis for parameter reduction, followed by a multivariate Gaussian fit that produces a stochastic model for keratoconus (SyntEyes KTC)...
March 17, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28300733/a-correlation-analysis-of-cone-characteristics-and-central-keratometric-readings-for-the-different-stages-of-keratoconus
#12
Alvin Jeffrey Munsamy, Vanessa Racquel Moodley
BACKGROUND: Knowledge of the cone characteristics for the different stages of keratoconus may potentially assist practitioners in diagnosing and managing keratoconic patients. AIM: This study aims to determine if any correlation exists between the central keratometric readings and the cone characteristics for the different stages of keratoconus. SETTING: A university eye clinic. MATERIALS AND METHODS: In this retrospective study, a saturated sample of 190 eyes from 106 cases of previously diagnosed keratoconic patient files was analyzed...
January 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28299302/cornea-collagen-cross-linking-for-keratoconus-a-comparison-between-accelerated-and-conventional-methods
#13
Hasan Razmjoo, Alireza Peyman, Ali Rahimi, Hoda Jafari Modrek
BACKGROUND: Keratoconus is a progressive degenerative disorder of the cornea in which structural changes in the cornea cause it to become thin and conical in shape. Recently, collagen cross-linking (CXL) has been introduced as an effective intervention in management of progressive keratoconus. Accelerated CXL is a new protocol of this procedure which reduces corneal ultraviolet irradiation exposure time to 5 min. This study aimed to compare visual acuity, keratometry and topographic criteria of keratoconic eyes after conventional and accelerated CXL with a six-month follow-up...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28270986/sub-micrometer-axial-resolution-oct-for-in-vivo-imaging-of-the-cellular-structure-of-healthy-and-keratoconic-human-corneas
#14
Kostadinka Bizheva, Bingyao Tan, Benjamin MacLelan, Olivera Kralj, Mojtaba Hajialamdari, Denise Hileeto, Luigina Sorbara
Corneal degenerative conditions such as keratoconus (KC) cause progressive damage to the anterior corneal tissue and eventually severely compromise visual acuity. The ability to visualize corneal tissue damage in-vivo at cellular or sub-cellular level at different stages of development of KC and other corneal diseases, can aid the early diagnostics as well as the development of more effective treatment approaches for various corneal pathologies, including keratoconus. Here, we present the optical design of an optical coherence tomography system that can achieve 0...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28261495/keraring-intrastromal-segment-depth-measured-by-spectral-domain-optical-coherence-tomography-in-eyes-with-keratoconus
#15
Ugo de Sanctis, Carlo Lavia, Marco Nassisi, Savino D'Amelio
Purpose. To evaluate agreement between measured and intended distance of Keraring (Mediphacos, Belo Horizonte, Brazil) intracorneal ring segments from the anterior and posterior corneal surfaces. Methods. Twenty-six Keraring ICRS implanted in 24 keratoconic eyes were examined. The distance from the Keraring apex to the anterior corneal surface and the distance from the inner and the outer corners to the posterior corneal surface were measured 3 months postoperatively using spectral-domain optical coherence tomography...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251158/molecular-and-histopathological-changes-associated-with-keratoconus
#16
REVIEW
Mariam Lotfy Khaled, Inas Helwa, Michelle Drewry, Mutsa Seremwe, Amy Estes, Yutao Liu
Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through ectasia, opacity, and irregular astigmatism. It is one of the leading indicators for corneal transplantation in the Western countries. KC usually starts at puberty and progresses until the third or fourth decade; however its progression differs among patients. In the keratoconic cornea, all layers except the endothelium have been shown to have histopathological structural changes. Despite numerous studies in the last several decades, the mechanisms of KC development and progression remain unclear...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28251081/effects-of-contact-lens-wearing-on-keratoconus-a-confocal-microscopy-observation
#17
Somnath Ghosh, Haliza A Mutalib, Sharanjeet-Kaur, Rituparna Ghoshal, Shamala Retnasabapathy
AIM: To evaluate the corneal cell morphology of new keratoconus patients wearing two different types of rigid gas-permeable (RGP) contact lenses for 1y. METHODS: Thirty nine eyes of 39 new keratoconus patients were selected and randomly fitted with two types of RGP contact lenses. Group 1 had 21 eyes with regular rigid gas-permeable (RRGP) contact lens and rest 18 eyes were in group 2 with specially designed rigid gas-permeable (SRGP) contact lens. Corneal cell morphology was evaluated using a slit scanning confocal microscope at no-lens wear and after 1y of contact lens wearing...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28215504/a-case-of-in-vivo-iontophoresis-assisted-corneal-collagen-cross-linking-for-keratoconus-an-immunohistochemical-study
#18
Mirko Manetti, Eleonora Favuzza, Eleonora Sgambati, Rita Mencucci, Mirca Marini
The standard corneal collagen cross-linking (CXL), that includes the removal of corneal epithelium to permit adequate penetration of riboflavin in the stroma, is an established procedure to halting keratoconus progression. However, as epithelial removal may cause postoperative pain and an increased risk of corneal infection, new therapeutic approaches have been proposed. Iontophoresis is a recently developed non-invasive technique which provides the use of electrical current during CXL to enhance transepithelial penetration of riboflavin into the corneal stroma...
February 15, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28165607/prevalence-of-eyelid-laxity-and-its-association-with-ophthalmic-findings-and-disease-severity-in-patients-with-keratoconus
#19
Mohammad Naderan, Ali Jahanrad, Mahgol Farjadnia
PURPOSE: To investigate the prevalence of eyelid laxity and quantify eyelid measurements in normal and keratoconic eyes and the correlations of these findings with ophthalmic parameters and disease severity in patients with keratoconus (KC). METHODS: In a prospective case-control study, prevalence of eyelid laxity and eyelid measurements were evaluated in 53 patients with KC and the same number of matched healthy controls. The eyelid measurements were compared between the groups, as well as mean keratometry (K), central and thinnest corneal thickness (CCT and TCT), astigmatism, manifest refraction spherical equivalent (MRSE), best spectacle-corrected visual acuity (BCVA), and severity of KC according to the Keratoconus Severity Score...
February 3, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28164597/visual-system-homeobox-1-vsx1-gene-analysis-in-keratoconus-design-of-specific-primers-and-dna-amplification-protocols-for-accurate-molecular-characterization
#20
Jun B Ng, Rozaida Y Y Poh, Kenneth R Lee, Visvaraja Subrayan, Jenny P Deva, Amy Y L Lau, Jin A M A Tan
BACKGROUND: Keratoconus is an ocular degeneration characterized by the thinning of corneal stroma that may lead to varying degrees of myopia and visual impairment. Genetic factors have been reported in the pathology of keratoconus where Asians have a higher incidence, earlier onset, and undergo earlier corneal grafts compared to Caucasians. The visual system homeobox 1 (VSX1) gene forms part of a paired-like homeodomain transcription factor which is responsible for ocular development...
September 1, 2016: Clinical Laboratory
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