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Vinay Kumar Nilagiri, Sangeetha Metlapally, Parthasarathi Kalaiselvan, Clifton M Schor, Shrikant R Bharadwaj
SIGNIFICANCE: This study showed an improvement in three-dimensional depth perception of subjects with bilateral and unilateral keratoconus with rigid gas-permeable (RGP) contact lens wear, relative to spectacles. This novel information will aid clinicians to consider RGP contact lenses as a management modality in keratoconic patients complaining of depth-related difficulties with their spectacles. PURPOSE: The aim of this study was to systematically compare changes in logMAR acuity and stereoacuity from best-corrected spherocylindrical spectacles to RGP contact lenses in bilateral and unilateral keratoconus vis-à-vis age-matched control subjects...
March 16, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Efstathios Vounotrypidis, Alexis Athanasiou, Karsten Kortüm, Daniel Kook, Mehdi Shajari, Siegfried Priglinger, Wolfgang J Mayer
PURPOSE: To investigate the long-term efficacy of accelerated corneal collagen cross-linking (CXL) in a large mid-European cohort with progressive keratoconus. METHODS: Four hundred thirteen eyes of 316 patients with progressive keratoconus were enrolled and treated with conventional (group A) or accelerated (group B) CXL. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), slit lamp, and Pentacam® examinations were performed before and 12, 24, and 36 months after surgery...
March 10, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Yu Meng Wang, Tsz Kin Ng, Kwong Wai Choy, Hoi Kin Wong, Wai Kit Chu, Chi Pui Pang, Vishal Jhanji
PURPOSE: To illustrate the histopathology of keratoconic corneal epithelia and its micro-ribonucleic acid (miRNA) regulation. METHODS: Corneal epithelia were collected from 27 patients with keratoconus and 26 normal patients after surgery or by impression cytology. The miRNA profile was determined using miRNA microarray. The biological roles of miRNA target genes were delineated by gene ontology and pathway analyses. The expressions of significant miRNAs were validated using TaqMan polymerase chain reaction (PCR), whereas protein localization and expression of the miRNA target genes were examined by immunofluorescence and immunoblotting analyses...
March 1, 2018: Journal of Refractive Surgery
Pinar Kosekahya, Mustafa Koc, Mehtap Caglayan, Hasan Kiziltoprak, Cemile Ucgul Atilgan, Pelin Yilmazbas
PURPOSE: To evaluate the repeatability and reliability of Belin-Ambrósio Enhanced Ectasia Display-III indices and topometric indices with a Scheimpflug system (Pentacam HR) in normal eyes and keratoconic eyes. SETTING: Ulucanlar Eye Research and Training Hospital, Ankara, Turkey. DESIGN: Prospective case series. METHODS: The same operator performed 3 consecutive successive measurements with the Scheimpflug device in the eyes of patients with keratoconus (keratoconus group) and healthy volunteers (normal group)...
January 2018: Journal of Cataract and Refractive Surgery
Niklas Pircher, Florian Schwarzhans, Stephan Holzer, Jan Lammer, Doreen Schmidl, Ahmed M Bata, Renè M Werkmeister, Gerald Seidel, Gerhard Garhöfer, Andreas Gschließer, Leopold Schmetterer, Gerald Schmidinger
PURPOSE: Discovering new predictive parameters in the diagnostics of Keratoconus (KC) has high priority. Aim of this trial was to find differences in epithelial thickness (ET) maps of eyes with KC and healthy eyes. DESIGN: Institutional cross-sectional study. METHODS: In this study 40 keratoconic eyes and 76 healthy eyes were scanned using a custom-built ultrahigh resolution OCT. Automated segmentation ET-maps with 17 subsectors were calculated (central, temporal inferior, temporal superior, nasal inferior and nasal superior area)...
February 16, 2018: American Journal of Ophthalmology
Weijun Jian, Yang Shen, Yingjun Chen, Mi Tian, Xingtao Zhou
BACKGROUND: Adolescent KC is a special segment of the general KC population because an adolescents's eyes are still susceptible to blurred vision and optical defocus during the sensitive period of ocular and visual development. In the present study, we evaluated the ocular dimensions of 53 KC adolescents. METHODS: One hundred and six KC eyes of 53 (42 boys and 11 girls) KC adolescents (age 15.5 ± 1.7 years, range 11 to 18) were involved in this retrospective study...
February 13, 2018: BMC Ophthalmology
Kristof Vandekerckhove
PURPOSE: To compare the rotational stability, total misalignment, and visual and refractive outcomes achieved with a trifocal toric versus a monofocal toric intraocular lens (IOL). METHODS: In this prospective, interventional case series, eyes of patients consecutively scheduled for cataract surgery who had clinically relevant astigmatism were implanted with a FineVision Pod FT trifocal toric IOL or an Ankoris monofocal toric IOL (both PhysIOL SA, Liège, Belgium)...
February 1, 2018: Journal of Refractive Surgery
Nathalie Bussières, Osama Hamid Ababneh, Mohammed Ali Abu Ameerh, Muawyah D Al Bdour
PURPOSE: To characterize the asymmetry between both eyes in patients with keratoconus based on corneal tomography. MATERIALS AND METHODS: All patients with keratoconus who presented to the eye clinic at Jordan University Hospital between January 2008 and November 2011 were included in the study. Using computerized corneal tomography, the keratometric values and indices of both eyes of participants with keratoconus and normal controls were compared. For both eyes to be considered symmetrical, the difference between the mean curvature power (Km), flat curvature power (K1), or steep curvature power (K2) in both eyes was equal to or <2...
October 2017: Middle East African Journal of Ophthalmology
Khosrow Jadidi, Seyed Aliasghar Mosavi
We describe an intrastromal corneal graft technique that uses femtosecond laser to create a desirable corneal lenticule with precise diameter, depth, and shape as well as an intra-stromal pocket in keratoconus patients. The technique seems to be a feasible and safe treatment option to treat keratoconic eyes with reference to the irregularity and instability of cornea. The technique can be performed easily and appears safe and effective. At 7 days postoperatively, all eyes were white and quiet, and the grafts were clear...
2018: International Medical Case Reports Journal
Ahmed Abass, John Clamp, FangJun Bao, Renato Ambrósio, Ahmed Elsheikh
PURPOSE: To investigate the prevalence of non-orthogonal astigmatism among normal and keratoconic Brazilian and Chinese populations. METHODS: Topography data were obtained using the Pentacam High Resolution (HR) system ® from 458 Brazilian (aged 35.6 ± 15.8 years) and 505 Chinese (aged 31.6 ± 10.8 years) eyes with no history of keratoconus or refractive surgery, and 314 Brazilian (aged 24.2 ± 5.7 years) and 74 Chinese (aged 22.0 ± 5.5 years) keratoconic eyes...
February 2, 2018: Current Eye Research
Alina Cantemir, Anisia-Iuliana Alexa, Bogdan Gabriel Galan, Nicoleta Anton, Roxana Elena Ciuntu, Ciprian Danielescu, Dorin Chiselita, Danut Costin
The purpose of this retrospective study was to report the results of iontophoretic corneal collagen crosslinking (I-CXL) with riboflavin and ultraviolet A irradiation in patients affected by keratoconus, each with thinnest pachymetry values of <400 μ (with epithelium) and not treatable using standard epithelium-off technique.Fifteen eyes of 15 patients affected by progressive keratoconus and with thinnest pachymetry values <400 μ underwent I-CXL. The uncorrected (UDVA) and corrected (CDVA) distance visual acuity, maximum and minimum keratometry (K max and K min) readings, corneal thickness at the thinnest point (CTTP), endothelial cell density (ECD), and intraocular pressure (IOP) were assessed before I-CXL, at 1, 3, 6, and 12 months postoperatively...
November 2017: Medicine (Baltimore)
Kazutaka Kamiya, Kei Iijima, Shoji Nobuyuki, Yosai Mori, Kazunori Miyata, Takefumi Yamaguchi, Jun Shimazaki, Shinya Watanabe, Naoyuki Maeda
This study was aimed to assess the predictability of intraocular lens (IOL) power calculation after cataract surgery for keratoconus. We retrospectively reviewed the clinical charts of 102 eyes of 71 consecutive keratoconic patients who developed cataract. We determined manifest spherical equivalent, prediction errors, and absolute errors, 1 month postoperatively. The achieved refraction was significantly more hyperopic than the targeted refraction, when keratometric readings were used (p = 0.001). At 1 month, 36% and 63% of the eyes were within ±0...
January 22, 2018: Scientific Reports
Cosimo Mazzotta, Claudio Traversi, Stefano Baiocchi, Simone Bagaglia, Orsola Caporossi, Antonio Villano, Aldo Caporossi
PURPOSE: To assess the 10-year follow-up efficacy and safety of riboflavin ultraviolet A-induced cross-linking (CXL) in a population of pediatric patients aged 18 years and younger with progressive keratoconus (KC). METHODS: The prospective longitudinal cohort study included 62 eyes of 47 keratoconic patients undergoing epithelium-off CXL who completed 10-year follow-up. The surgical procedure was performed in all patients according to the Siena (Dresden modified) protocol...
January 9, 2018: Cornea
Wolf Wonneberger, Bertil Sterner, Ulrika MacLean, Margareta Claesson, Madeleine Zetterberg
PURPOSE: Corneal tomography is used to assess progression of keratoconus and to direct clinical decisions regarding corneal cross-linking. The purpose of this study was to analyze the variability of repeated Scheimpflug-tomography (Pentacam Classic; Oculus, Wetzlar, Germany) measurements of keratoconic eyes in a clinical setting and to assess the validity of such measurements as a clinical decision-making tool. METHODS: Eighty keratoconic eyes of 45 patients (age range 16-32 years) were examined at baseline and after follow-up periods of 3 to 6 months using 3 consecutive tomography measurements at each visit...
January 9, 2018: Cornea
Vincenzo Scorcia, Valentina De Luca, Andrea Lucisano, Adriano Carnevali, Giovanna Carnovale Scalzo, Cristina Bovone, Massimo Busin
AIM: To report the outcomes of bubble formation obtained by means of intrastromal injection of ophthalmic viscoelastic device (OVD) after failure of pneumatic dissection for deep anterior lamellar keratoplasty (DALK). METHODS: DALK was performed in 140 keratoconic eyes of 130 patients by injecting air and OVD only secondarily, after pneumatic dissection had failed; the bubble formation rates after air and OVD injection were recorded; complications, best spectacle-corrected visual acuity (BSCVA) and corneal tomographic parameters were evaluated 3 months, 6 months and 12 months postoperatively, as well as after complete suture removal...
December 23, 2017: British Journal of Ophthalmology
YaRu Zheng, LiFang Huang, YiPing Zhao, JunJie Wang, XiaoBo Zheng, Wei Huang, Brendan Geraghty, QinMei Wang, ShiHao Chen, FangJun Bao, Ahmed Elsheikh
To assess repeatability of corneal tomography in successive measurements by Pentacam in keratoconus (KC) and normal eyes based on the Iterative Closest Point (ICP) algorithm. The study involved 143 keratoconic and 143 matched normal eyes. ICP algorithm was used to estimate six single and combined misalignment (CM) parameters, the root mean square (RMS) of the difference in elevation data pre (PreICP-RMS) and post (PosICP-RMS) tomography matching. Corneal keratometry, expressed in the form of M, J0 and J45 (power vector analysis parameters), was used to evaluate the effect of misalignment on corneal curvature measurements...
December 12, 2017: Scientific Reports
J J Males, D Viswanathan
PurposeTo compare the long-term outcomes of accelerated corneal collagen crosslinking (CXL) to conventional CXL for progressive keratoconus.Patients and methodsComparative clinical study of consecutive progressive keratoconic eyes that underwent either accelerated CXL (9 mW/cm2 ultraviolet A (UVA) light irradiance for 10 min) or conventional CXL (3 mW/cm2 UVA light irradiance for 30 min). Eyes with minimum 12 months' follow-up were included. Post-procedure changes in keratometry readings (Flat meridian: K1; steep meridian: K2), central corneal thickness (CCT), best spectacle-corrected visual acuity (BSCVA), and manifest refraction spherical equivalent (MRSE) were analysed...
January 2018: Eye
Mark J Mannis, Jennifer J Ling, Ralph Kyrillos, Melissa Barnett
PURPOSE: To assess the existing literature on the subject of keratoconus and personality and to propose a theory that might account for the perceived personality changes associated with this condition. METHODS: A literature search was conducted in the PubMed database using the term "keratoconus" in combination with keywords such as personality, psychiatry, psychology, anxiety, depression, or psychosis. A total of 15 articles pertaining to personality and psychiatric disorders in keratoconus were retained and reviewed...
March 2018: Cornea
Aazim A Siddiqui, Uday Devgan
Cataract surgery is the most performed surgical procedure in the field of ophthalmology. The process of intraocular lens (IOL) calculations is a critical step to achieving successful outcomes. Many IOL formulae exist to guide surgeons through the difficult process of picking the most appropriate lens to achieve a certain target refraction. However, these formulae reach within 0.50 diopters of the target refraction only 75% of the time, leaving 25% of the eyes with a significant refractive surprise. A literature review was performed to investigate all the relevant published material on the history, progress, and recent advancements of IOL calculations...
December 2017: Indian Journal of Ophthalmology
Hatem Kalantan, Altaf A Kondkar, Tahira Sultan, Taif A Azad, Nasser A Alsabaani, Masoud Ali AlQahtani, Abdulrahman Almummar, Yuato Liu, Khaled K Abu-Amero
OBJECTIVE: Polymorphism rs13334190 in the zinc finger protein 469 gene has been suggested to predispose toward a "thin" cornea, which then becomes keratoconic or is directly pathogenic. Thus, we genotyped polymorphism rs13334190 in 127 unrelated keratoconus cases and 168 control subjects from Saudi Arabia using Taq-Man® assay. RESULTS: The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05)...
November 29, 2017: BMC Research Notes
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