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https://www.readbyqxmd.com/read/29319598/corneal-collagen-cross-linking-with-riboflavin-and-ultraviolet-a-light-for-pediatric-keratoconus-ten-year-results
#1
Cosimo Mazzotta, Claudio Traversi, Stefano Baiocchi, Simone Bagaglia, Orsola Caporossi, Antonio Villano, Aldo Caporossi
PURPOSE: To assess the 10-year follow-up efficacy and safety of riboflavin ultraviolet A-induced cross-linking (CXL) in a population of pediatric patients aged 18 years and younger with progressive keratoconus (KC). METHODS: The prospective longitudinal cohort study included 62 eyes of 47 keratoconic patients undergoing epithelium-off CXL who completed 10-year follow-up. The surgical procedure was performed in all patients according to the Siena (Dresden modified) protocol...
January 9, 2018: Cornea
https://www.readbyqxmd.com/read/29319597/repeated-same-day-versus-single-tomography-measurements-of-keratoconic-eyes-for-analysis-of-disease-progression
#2
Wolf Wonneberger, Bertil Sterner, Ulrika MacLean, Margareta Claesson, Madeleine Zetterberg
PURPOSE: Corneal tomography is used to assess progression of keratoconus and to direct clinical decisions regarding corneal cross-linking. The purpose of this study was to analyze the variability of repeated Scheimpflug-tomography (Pentacam Classic; Oculus, Wetzlar, Germany) measurements of keratoconic eyes in a clinical setting and to assess the validity of such measurements as a clinical decision-making tool. METHODS: Eighty keratoconic eyes of 45 patients (age range 16-32 years) were examined at baseline and after follow-up periods of 3 to 6 months using 3 consecutive tomography measurements at each visit...
January 9, 2018: Cornea
https://www.readbyqxmd.com/read/29275378/results-of-viscobubble-deep-anterior-lamellar-keratoplasty-after-failure-of-pneumatic-dissection
#3
Vincenzo Scorcia, Valentina De Luca, Andrea Lucisano, Adriano Carnevali, Giovanna Carnovale Scalzo, Cristina Bovone, Massimo Busin
AIM: To report the outcomes of bubble formation obtained by means of intrastromal injection of ophthalmic viscoelastic device (OVD) after failure of pneumatic dissection for deep anterior lamellar keratoplasty (DALK). METHODS: DALK was performed in 140 keratoconic eyes of 130 patients by injecting air and OVD only secondarily, after pneumatic dissection had failed; the bubble formation rates after air and OVD injection were recorded; complications, best spectacle-corrected visual acuity (BSCVA) and corneal tomographic parameters were evaluated 3 months, 6 months and 12 months postoperatively, as well as after complete suture removal...
December 23, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29234085/repeatability-of-corneal-elevation-maps-in-keratoconus-patients-using-the-tomography-matching-method
#4
YaRu Zheng, LiFang Huang, YiPing Zhao, JunJie Wang, XiaoBo Zheng, Wei Huang, Brendan Geraghty, QinMei Wang, ShiHao Chen, FangJun Bao, Ahmed Elsheikh
To assess repeatability of corneal tomography in successive measurements by Pentacam in keratoconus (KC) and normal eyes based on the Iterative Closest Point (ICP) algorithm. The study involved 143 keratoconic and 143 matched normal eyes. ICP algorithm was used to estimate six single and combined misalignment (CM) parameters, the root mean square (RMS) of the difference in elevation data pre (PreICP-RMS) and post (PosICP-RMS) tomography matching. Corneal keratometry, expressed in the form of M, J0 and J45 (power vector analysis parameters), was used to evaluate the effect of misalignment on corneal curvature measurements...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29219951/comparative-study-of-long-term-outcomes-of-accelerated-and-conventional-collagen-crosslinking-for-progressive-keratoconus
#5
J J Males, D Viswanathan
PurposeTo compare the long-term outcomes of accelerated corneal collagen crosslinking (CXL) to conventional CXL for progressive keratoconus.Patients and methodsComparative clinical study of consecutive progressive keratoconic eyes that underwent either accelerated CXL (9 mW/cm2 ultraviolet A (UVA) light irradiance for 10 min) or conventional CXL (3 mW/cm2 UVA light irradiance for 30 min). Eyes with minimum 12 months' follow-up were included. Post-procedure changes in keratometry readings (Flat meridian: K1; steep meridian: K2), central corneal thickness (CCT), best spectacle-corrected visual acuity (BSCVA), and manifest refraction spherical equivalent (MRSE) were analysed...
December 8, 2017: Eye
https://www.readbyqxmd.com/read/29215397/keratoconus-and-personality-a-review
#6
Mark J Mannis, Jennifer J Ling, Ralph Kyrillos, Melissa Barnett
PURPOSE: To assess the existing literature on the subject of keratoconus and personality and to propose a theory that might account for the perceived personality changes associated with this condition. METHODS: A literature search was conducted in the PubMed database using the term "keratoconus" in combination with keywords such as personality, psychiatry, psychology, anxiety, depression, or psychosis. A total of 15 articles pertaining to personality and psychiatric disorders in keratoconus were retained and reviewed...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29208808/intraocular-lens-calculations-in-atypical-eyes
#7
REVIEW
Aazim A Siddiqui, Uday Devgan
Cataract surgery is the most performed surgical procedure in the field of ophthalmology. The process of intraocular lens (IOL) calculations is a critical step to achieving successful outcomes. Many IOL formulae exist to guide surgeons through the difficult process of picking the most appropriate lens to achieve a certain target refraction. However, these formulae reach within 0.50 diopters of the target refraction only 75% of the time, leaving 25% of the eyes with a significant refractive surprise. A literature review was performed to investigate all the relevant published material on the history, progress, and recent advancements of IOL calculations...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29187250/polymorphism-rs13334190-in-zinc-finger-protein-469-znf469-is-not-a-risk-factor-for-keratoconus-in-a-saudi-cohort
#8
Hatem Kalantan, Altaf A Kondkar, Tahira Sultan, Taif A Azad, Nasser A Alsabaani, Masoud Ali AlQahtani, Abdulrahman Almummar, Yuato Liu, Khaled K Abu-Amero
OBJECTIVE: Polymorphism rs13334190 in the zinc finger protein 469 gene has been suggested to predispose toward a "thin" cornea, which then becomes keratoconic or is directly pathogenic. Thus, we genotyped polymorphism rs13334190 in 127 unrelated keratoconus cases and 168 control subjects from Saudi Arabia using Taq-Man® assay. RESULTS: The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg equilibrium (p > 0.05). Overall, both the genotype and allele frequencies were not significantly different between cases and controls...
November 29, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29181311/scanning-slit-topography-in-patients-with-keratoconus
#9
László Módis, Gábor Németh, Eszter Szalai, Zsuzsa Flaskó, Berthold Seitz
AIM: To evaluate the anterior and posterior corneal surfaces using scanning-slit topography and to determine the diagnostic ability of the measured corneal parameters in keratoconus. METHODS: Orbscan II measurements were taken in 39 keratoconic corneas previously diagnosed by corneal topography and in 39 healthy eyes. The central minimum, maximum, and astigmatic simulated keratometry (K) and anterior axial power values were determined. Spherical and cylindrical mean power diopters were obtained at the central and at the steepest point of the cornea both on anterior and on posterior mean power maps...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29171504/intraoperative-optical-coherence-tomography-to-evaluate-the-effect-of-the-eyelid-speculum-on-corneal-pachymetry-during-accelerated-corneal-cross-linking-9%C3%A2-mw-cm-2
#10
R Ghaffari, M Mortazavi, P Anvari, A Salamat Rad, F Alipour, F Hafezi, S Asgari, H Hashemi
PurposeTo investigate intraoperative anterior segment optical coherence tomography (AS-OCT) to compare pachymetry changes between two methods (group 1: speculum-on, group 2: speculum-off during riboflavin instillation stage) during corneal cross-linking /CXL) (9 mW/cm(2) for 10 min) in keratoconic patients.MethodsIn this interventional case series, 11 eyes (11 patients) in group 1 and 14 eyes (14 patients) in group 2 were enrolled. Pachymetry measurements by spectral domain OCT was performed at baseline, after epithelial removal, after 30 min of imbibition with riboflavin, and after UV irradiation...
November 24, 2017: Eye
https://www.readbyqxmd.com/read/29160595/advanced-anterior-segment-imaging-in-keratoconus-a-review
#11
REVIEW
Akilesh Gokul, Hans R Vellara, Dipika V Patel
Advances in anterior segment imaging have enhanced our ability to detect keratoconus in its early stages and characterize the pathologic changes that occur. Computerized corneal tomography has elucidated the alterations in shape of the anterior and posterior corneal surfaces and alterations in thickness as the disease progresses. Automated screening indices such as the keratoconus screening index were developed to assist in detecting keratoconus in suspicious cases. In vivo assessment of keratoconic corneas has revealed that compromised corneal biomechanics can now be measured clinically...
November 21, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29135710/adjustment-of-intrastromal-corneal-ring-segments-after-unsuccessful-implantation-in-keratoconic-eyes
#12
Tiago Monteiro, José Ferreira Mendes, Fernando Faria-Correia, Nuno Franqueira, David Madrid-Costa, José F Alfonso
PURPOSE: To evaluate visual, refractive, and corneal topography outcomes in eyes with keratoconus that have undergone exchange/adjustment surgery with a new intrastromal corneal ring segment (ICRS) combination after unsuccessful visual and/or refractive outcomes after primary ICRS surgery. METHODS: A retrospective nonrandomized case series was conducted including consecutive eyes of patients with keratoconus that underwent ICRS adjustment after an unsuccessful visual outcome...
February 2018: Cornea
https://www.readbyqxmd.com/read/29124079/identifying-more-reliable-parameters-for-the-detection-of-change-during-the-follow-up-of-mild-to-moderate-keratoconus-patients
#13
Ivo Guber, Colm McAlinden, François Majo, Ciara Bergin
Background: Reaching a consensus on which parameters are most reliable at detecting progressive keratoconus patients with serial topography imaging is not evident. The aim of the study was to isolate the parameters best positioned to detect keratoconus progression using the Pentacam HR® measures based on the respective limits of repeatability and range of measurement. Method: Using the Pentacam HR®, a tolerance index was calculated on anterior segment parameters in healthy and keratoconic eyes...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/29120713/waveform-analysis-of-deformation-amplitude-and-deflection-amplitude-in%C3%A2-normal-suspect-and-keratoconic-eyes
#14
Mathew Francis, Natasha Pahuja, Rushad Shroff, Roshan Gowda, Himanshu Matalia, Rohit Shetty, Everette J Remington Nelson, Abhijit Sinha Roy
PURPOSE: To evaluate the performance of waveform-derived variables in distinguishing normal, suspect, and keratoconic eyes. SETTING: Narayana Nethralaya Eye Hospital, Bangalore, India. DESIGN: Retrospective case series. METHODS: Scheimpflug tomography (Pentacam) and dynamic Scheimpflug analysis (Corvis ST) of 253 normal (253 patients) eyes and 205 keratoconic eyes (205 patients) were evaluated. Among the 205 patients, 62 had keratoconus in 1 eye, while the unaffected eye was suspect...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29120711/combined-transepithelial-phototherapeutic-keratectomy-and-conventional-photorefractive-keratectomy-followed-simultaneously-by-corneal-crosslinking-for-keratoconus-cretan-protocol-plus
#15
Michael A Grentzelos, George A Kounis, Vasilios F Diakonis, Charalambos S Siganos, Miltiadis K Tsilimbaris, Ioannis G Pallikaris, George D Kymionis
PURPOSE: To evaluate the visual, refractive, and topographic outcomes after combined transepithelial phototherapeutic keratectomy (PTK) and conventional photorefractive keratectomy (PRK) followed simultaneously by corneal crosslinking (CXL) for keratoconus. SETTING: Vardinoyiannion Eye Institute of Crete, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece. DESIGN: Prospective case series. METHODS: Patients with progressive keratoconus had simultaneous conventional PRK followed by CXL; the corneal epithelium was removed using transepithelial PTK (Cretan protocol plus)...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29120710/femtosecond-laser-implantation-of%C3%A2-a%C3%A2-340-degree-intrastromal-corneal-ring%C3%A2-segment-in-keratoconus-short-term%C3%A2-outcomes
#16
Mohammad Mehdi Sadoughi, Bahram Einollahi, Amir Reza Veisi, Mohammad Zare, Mohammad Reza Sedaghat, Danial Roshandel, Neda Einollahi, Javad Rezaei
PURPOSE: To evaluate the short-term outcomes of femtosecond laser-assisted implantation of a 340-degree intracorneal ring (ICR) (Keraring) in patients with keratoconus. SETTING: Four centers in Iran. DESIGN: Prospective case series. METHODS: All cases had implantation of the 340-degree ICR after tunnel creation with a femtosecond laser. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, sphere, cylinder, manifest refraction spherical equivalent (MRSE), mean keratometry (K), steep K, and flat K were evaluated preoperatively and 1, 3, and 6 months postoperatively...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29117418/keratoconus-screening-with-dynamic-biomechanical-in-vivo-scheimpflug-analyses-a-proof-of-concept-study
#17
Johannes Steinberg, Nazanin Eslami Amirabadi, Andreas Frings, Juliane Mehlan, Toam Katz, Stephan J Linke
PURPOSE: This proof-of-concept study was designed to analyze the ability of in vivo biomechanical corneal analyses with the corneal visualization Scheimpflug technology (CorvisST; Oculus Optikgeräte, Wetzlar, Germany) to differentiate between normal eyes and eyes with manifest keratoconus after strictly eliminating the potential confounding factors intraocular pressure (IOP) and central corneal thickness (CCT). METHODS: In this retrospective, cross-sectional study, after pairwise matching for CCT and IOP, 29 normal eyes and 29 keratoconic eyes (one eye from each patient) were selected as study population...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29117417/repeatability-of-a-commercially-available-adaptive-optics-visual-simulator-and-aberrometer-in-normal-and-keratoconic-eyes
#18
Rohit Shetty, Shruti Kochar, Tushar Grover, Pooja Khamar, Pallak Kusumgar, Kanchan Sainani, Abhijit Sinha Roy
PURPOSE: To evaluate the repeatability of aberration measurement obtained by a Hartmann-Shack aberrometer combined with a visual adaptive optics simulator in normal and keratoconic eyes. METHODS: One hundred fifteen normal eyes and 92 eyes with grade I and II keratoconus, as per the Amsler-Krumeich classification, were included in the study. To evaluate the repeatability, three consecutive measurements of ocular aberrations were obtained by a single operator. Zernike analyses up to the 5th order for a pupil size of 4...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29032110/use-of-donors-predisposed-by-corneal-collagen-cross-linking-in-penetrating-keratoplasty-for-treating-the-patients-with-keratoconus
#19
Ting Huang, Ruifen Ye, Chen Ouyang, Chao Hou, Yunwei Hu, Qianni Wu
PURPOSE: To investigate whether use of donors predisposed by corneal collagen cross-linking (CXL) reduced myopic refractive errors for keratoconic eyes after penetrating keratoplasty (PK). DESIGN: Randomized controlled trial. METHODS: One hundred sixteen eyes of 116 patients with keratoconus from Zhongshan Ophthalmic Center were enrolled. Using stratified block randomization, eligible eyes were assigned to CXL graft group (Group1) or conventional graft group (Group2)...
October 12, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28991335/customized-corneal-cross-linking-using-different-uva-beam-profiles
#20
Rohit Shetty, Natasha Pahuja, Thimmarayappa Roshan, Rashmi Deshmukh, Mathew Francis, Arkasubhra Ghosh, Abhijit Sinha Roy
PURPOSE: To evaluate the performance of different customized corneal cross-linking (CXL) methods. METHODS: This was a single-center interventional, prospective, longitudinal case series. Four different customized CXL methods were evaluated in keratoconic eyes: (1) uniform (uniform intensity ultraviolet-A [UVA] beam [9 mW/cm(2)] for 10 minutes) (n = 12 eyes); (2) sector axial map (sector-based UVA irradiation) (n = 12 eyes); (3) ring axial map (concentric rings of UVA beam intensity centered at the steepest curvature of the anterior axial map) (n = 12 eyes); and ring tangential map (same as the ring axial map but centered at the steepest curvature of the anterior tangential map) (n = 14 eyes)...
October 1, 2017: Journal of Refractive Surgery
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