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Keratocone

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https://www.readbyqxmd.com/read/28215504/a-case-of-in-vivo-iontophoresis-assisted-corneal-collagen-cross-linking-for-keratoconus-an-immunohistochemical-study
#1
Mirko Manetti, Eleonora Favuzza, Eleonora Sgambati, Rita Mencucci, Mirca Marini
The standard corneal collagen cross-linking (CXL), that includes the removal of corneal epithelium to permit adequate penetration of riboflavin in the stroma, is an established procedure to halting keratoconus progression. However, as epithelial removal may cause postoperative pain and an increased risk of corneal infection, new therapeutic approaches have been proposed. Iontophoresis is a recently developed non-invasive technique which provides the use of electrical current during CXL to enhance transepithelial penetration of riboflavin into the corneal stroma...
February 15, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28165607/prevalence-of-eyelid-laxity-and-its-association-with-ophthalmic-findings-and-disease-severity-in-patients-with-keratoconus
#2
Mohammad Naderan, Ali Jahanrad, Mahgol Farjadnia
PURPOSE: To investigate the prevalence of eyelid laxity and quantify eyelid measurements in normal and keratoconic eyes and the correlations of these findings with ophthalmic parameters and disease severity in patients with keratoconus (KC). METHODS: In a prospective case-control study, prevalence of eyelid laxity and eyelid measurements were evaluated in 53 patients with KC and the same number of matched healthy controls. The eyelid measurements were compared between the groups, as well as mean keratometry (K), central and thinnest corneal thickness (CCT and TCT), astigmatism, manifest refraction spherical equivalent (MRSE), best spectacle-corrected visual acuity (BCVA), and severity of KC according to the Keratoconus Severity Score...
February 3, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28164597/visual-system-homeobox-1-vsx1-gene-analysis-in-keratoconus-design-of-specific-primers-and-dna-amplification-protocols-for-accurate-molecular-characterization
#3
Jun B Ng, Rozaida Y Y Poh, Kenneth R Lee, Visvaraja Subrayan, Jenny P Deva, Amy Y L Lau, Jin A M A Tan
BACKGROUND: Keratoconus is an ocular degeneration characterized by the thinning of corneal stroma that may lead to varying degrees of myopia and visual impairment. Genetic factors have been reported in the pathology of keratoconus where Asians have a higher incidence, earlier onset, and undergo earlier corneal grafts compared to Caucasians. The visual system homeobox 1 (VSX1) gene forms part of a paired-like homeodomain transcription factor which is responsible for ocular development...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28129298/copper-in-keratoconic-corneas
#4
Lubica Dudakova, Cerys J Evans, Petra Liskova
No abstract text is available yet for this article.
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/28089285/thick-keratoconic-cornea-associated-with-posterior-polymorphous-corneal-dystrophy
#5
K Zaarour, E Slim, J Antoun, N Waked
INTRODUCTION: We herein report a case of bilateral unusually thick non-edematous keratoconic corneas with associated endothelial features of posterior polymorphous corneal dystrophy (PPCD). CASE REPORT: We report the case of a 27-year-old myopic woman who presented for refractive surgery. Slit lamp exam showed bilateral corneal protrusion with diffuse deep stromal and endothelial vesicular opacities and small paracentral bands. Topography showed generalized advanced corneal steepening in both eyes with increased anterior and posterior central corneal elevations in comparison to the best fit sphere...
January 12, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27994389/characteristics-of-keratoconic-patients-attending-a-specialist-contact-lens-clinic-in-kenya
#6
Zahra Aly Rashid, Michel Millodot, Katharine S E Evans
PURPOSE: To describe the characteristics of keratoconus (KC) patients seen in a contact lens clinic of a children's hospital in Kenya. RESULTS: A total of 254 patients' records were analyzed. Mean age at presentation to the clinic was 20.97 ± 11.13 year (range, 6-84 years) with 75% between the ages of 6 and 25 years. There was a preponderance of males (59.8%). Most patients were referred by an ophthalmologist. All patients were Africans. The most common complaints were blurred vision (50%), poor visual acuity with spectacles (33...
October 2016: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/27993593/repeatability-and-agreement-of-orbscan-ii-pentacam-hr-and-galilei-tomography-systems-in-corneas-with-keratoconus
#7
Jay J Meyer, Akilesh Gokul, Hans R Vellara, Zak Prime, Charles Nj McGhee
PURPOSE: To assess the repeatability and agreement of keratometry and pachymetry measurements obtained using three tomographers in eyes with keratoconus. DESIGN: Reliability analysis. METHODS: Setting: Institutional. STUDY POPULATION: 50 eyes of 50 participants with keratoconus. Observational Procedure: Steep keratometry, flat keratometry, central corneal thickness (CCT), and thinnest corneal thickness (TCT) measurements using Galilei, Orbscan II, and Pentacam HR...
December 16, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27956045/biomechanical-properties-of-early-keratoconus-suppressed-deformation-signal-wave
#8
Hassan Hashemi, Asghar Beiranvand, Abbasali Yekta, Amir Asharlous, Mehdi Khabazkhoob
PURPOSE: To examine the diagnostic validity of different corneal biomechanical parameters for the detection of early keratoconus METHODS: Sixty-one eyes with a diagnosis of early keratoconus and 61 topographically normal eyes were enrolled in the study. All participants underwent testing with the Ocular Response Analyzer (ORA), and 40 indices from each cornea were included in the analysis. RESULTS: The mean (standard deviation: SD) of keratometry and central corneal thickness in keratoconic corneas was 46...
December 9, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27930793/intracorneal-ring-segments-implantation-for-corneal-ectasia
#9
Natalia T Giacomin, Glauco R Mello, Carla S Medeiros, Alyin Kiliç, Cristine C Serpe, Hirlana G Almeida, Newton Kara-Junior, Marcony R Santhiago
PURPOSE: To provide an overview of the predictability, safety, and efficacy of intrastromal corneal ring segment (ICRS) implantation as a tool to improve visual acuity and its association with other techniques such as corneal collagen cross-linking (CXL), addressing biomechanical outcomes, models, surgical planning and technique, indications, contraindications, and complications in ectatic corneas. METHODS: Literature review. RESULTS: ICRSs have been used to regularize the corneal shape and reduce corneal astigmatism and higher order aberrations, improve visual acuity to acceptable limits, and delay, or eventually prevent, a corneal keratoplasty in keratoconic eyes...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27930790/detection-of-keratoconus-with-a-new-biomechanical-index
#10
Riccardo Vinciguerra, Renato Ambrósio, Ahmed Elsheikh, Cynthia J Roberts, Bernardo Lopes, Emanuela Morenghi, Claudio Azzolini, Paolo Vinciguerra
PURPOSE: To evaluate the ability of a new combined biomechanical index called the Corvis Biomechanical Index (CBI) based on corneal thickness profile and deformation parameters to separate normal from keratoconic patients. METHODS: Six hundred fifty-eight patients (329 eyes in each database) were included in this multicenter retrospective study. Patients from two clinics located on different continents were selected to test the capability of the CBI to separate healthy and keratoconic eyes in more than one ethnic group using the Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany)...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27897442/pupillary-offset-in-keratoconus-and-its-relationship-with-clinical-and-topographical-features
#11
Gozde Hondur, Nurullah Cagil, Ozge Sarac, Meltem Ece Ozcan, Pinar Kosekahya
PURPOSE: To evaluate the change in the location of pupillary center with corneal tomography in keratoconic patients, and determine the correlation of pupillary offset with clinical and topographical features of keratoconus. METHODS: Ninety-one eyes of the 54 patients with keratoconus in different stages and 39 eyes of 39 refractive surgery candidates with normal corneas were included in our study. Ocular aberrations and the pupillary offset parameters (x-offset and y-offset) over a 5 mm (undilated) pupil were measured with a Sirius corneal tomographer...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27830203/corneal-aberration-changes-after-rigid-gas-permeable-contact-lens-wear-in-keratokonic-patients
#12
Fereshteh Shokrollahzadeh, Hassan Hashemi, Ebrahim Jafarzadehpur, Ali Mirzajani, Mehdi Khabazkhoob, Abbasali Yekta, Soheila Asgari
PURPOSE: To determine the short-term effect of rigid gas permeable (RGP) contact lenses on corneal aberrations in keratoconic patients. METHOD: Sixteen keratoconic eyes with no history of RGP lens wear were included. They all had corneal aberrometry using Pentacam, and different aberration indices of the anterior and posterior surfaces of the cornea were measured before and 3 months after fitting RGP lenses. The effect of baseline parameters on these changes was tested in univariate and multiple models...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27824380/double-pass-retina-point-imaging-for-the-evaluation-of-optical-light-scatter-retinal-image-quality-and-staging-of-keratoconus
#13
Anthony P Leonard, Scott D Gardner, Karolinne M Rocha, Evan R Zeldin, David M Tremblay, George O Waring
PURPOSE: To measure retinal image quality using point spread function (PSF) analysis by double-pass retina point imaging in patients with keratoconus and to correlate visual quality with disease severity. METHODS: Patients diagnosed as having keratoconus by clinical examination, topography, and tomography and normal eyes were included in this study. A commercially available double-pass retina point imaging instrument (OQAS 108 II AcuTarget HD; Visiometrics S.L., Terrassa, Spain) was used to collect Objective Scatter Index (OSI) values in 21 keratoconic and 22 normal eyes...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27805316/comparison-of-corneal-measurements-in-keratoconus-using-swept-source-optical-coherence-tomography-and-combined-placido-scheimpflug-imaging
#14
Tommy C Y Chan, Sayantan Biswas, Marco Yu, Vishal Jhanji
PURPOSE: The aim of this study was to provide a comprehensive comparison of reliability of corneal topographic measurements in keratoconic eyes using swept-source optical coherence tomography (OCT) and a combined Placido-Scheimpflug imaging. METHODS: A total of 30 eyes of 30 patients were included. The mean age was 31.2 ± 8.4 years. Two consecutive topographic measurements were obtained for one eye of each patient using swept-source OCT (CASIA) and combined Placido-Scheimpflug imaging (TMS-5)...
November 2, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27804048/clinical-evaluation-of-two-types-of-intracorneal-ring-segments-icrs-for-keratoconus
#15
Waleed S Al-Tuwairqi, Uchechukwu L Osuagwu, Haya Razzouk, Ahmed AlHarbi, Kelechi C Ogbuehi
PURPOSE: To compare the outcome measures following implantation of two types of ICRS. METHODS: Forty-four eyes of keratoconic patients (aged 18-50 years) were randomly assigned to femtosecond laser-assisted Keraring ICRS (Group A) or MyoRing (Group B) implantation. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, keratometry (K), and aberrations were compared preoperatively, at 3 and 6 months postoperatively. A survey was conducted to assess patient's satisfaction, 6 months postoperatively...
November 1, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27752122/training-to-improve-contrast-sensitivity-in-amblyopia-correction-of-high-order-aberrations
#16
Meng Liao, Haoxing Zhao, Longqian Liu, Qian Li, Yun Dai, Yudong Zhang, Yifeng Zhou
Perceptual learning is considered a potential treatment for amblyopia even in adult patients who have progressed beyond the critical period of visual development because adult amblyopes retain sufficient visual plasticity. When perceptual learning is performed with the correction of high-order aberrations (HOAs), a greater degree of neural plasticity is present in normal adults and those with highly aberrated keratoconic eyes. Because amblyopic eyes show more severe HOAs than normal eyes, it is interesting to study the effects of HOA-corrected visual perceptual learning in amblyopia...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27749450/morphology-of-the-corneal-limbus-following-standard-and-accelerated-corneal-collagen-cross-linking-9-mw-cm2-for-keratoconus
#17
Ömür Ö Uçakhan, Betül Bayraktutar
PURPOSE: To evaluate the morphological features of the corneal limbus as measured by in vivo confocal microscopy (IVCM) following standard and accelerated corneal collagen cross-linking (CXL) for keratoconus. METHODS: Patients with progressive keratoconus scheduled to undergo standard CXL (group 1; 31 patients, 3 mW/cm, 370 nm, 30 minutes), or accelerated CXL (group 2; 20 patients, 9 mW/cm, 370 nm, 10 minutes) in the worse eye were included in this prospective study...
January 2017: Cornea
https://www.readbyqxmd.com/read/27688908/corneal-biomechanical-findings-in-contact-lens-induced-corneal-warpage
#18
Fateme Alipour, Mojgan Letafatnejad, Amir Hooshang Beheshtnejad, Seyed-Farzad Mohammadi, Seyed Reza Ghaffary, Narges Hassanpoor, Mehdi Yaseri
Purpose. To evaluate the difference in biomechanical properties between contact lens induced corneal warpage and normal and keratoconic eyes. Method. Prospective observational case control study, where 94 eyes of 47 warpage suspicious and 46 eyes of 23 keratoconic patients were included. Warpage suspected cases were followed until a definite diagnosis was made (warpage, normal, or keratoconus). Results. 44 eyes of 22 patients had contact lens related corneal warpage. 46 eyes of 23 people were diagnosed as nonwarpage normal eyes...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27661992/measuring-intraocular-pressure-in-patients-with-keratoconus-with-and-without-intrastromal-corneal-ring-segments
#19
Carmen Mendez-Hernandez, Paula Arribas-Pardo, Ricardo Cuiña-Sardiña, Cristina Fernandez-Perez, Rosalia Mendez-Fernandez, Federico Saenz-Frances, Jose M Benitez-Del-Castillo, Julian Garcia-Feijoo
PURPOSE: To compare intraocular pressure (IOP) measurements made using 5 tonometers in keratoconic eyes with and without intrastromal corneal ring segments. METHODS AND PATIENTS: This was an observational case series study. A total of 147 eyes of 147 patients with keratoconus, 74 of which had undergone corneal ring segment placement, were prospectively evaluated. IOP was measured using the tonometers Tonopen XL, Pascal dynamic contour tonometer, iCare Pro, ocular response analyzer (ORA), and Goldmann applanation (GAT) in random order...
January 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/27647247/-corneal-biomechanical-properties-in-keratoconic-and-normal-eyes
#20
S S Wei, Y Li, J Li, J G Liu, L Ye, Y Q Wan, J Li, J Du
OBJECTIVE: To compare the corneal biomechanical properties of keratoconic and normal eyes, and to explore the changing characteristics in keratoconic eyes. METHODS: Case-control study. Thirty-two keratoconic subjects(41 eyes)and 41 subjects(41 eyes)with normal corneas were enrolled in this study. Scheimpflug noncontact tonometry(Corvis ST)was performed to measure the length of Appl 1(1st A length), velocity of Appl 1(Vin), length of Appl 2(2nd A length), velocity of Appl 2(Vout), deformation amplitude(DA), peak distance, and radius...
September 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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