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https://www.readbyqxmd.com/read/29242786/radius-and-ulna-stress-fractures-in-a-patient-with-neuromyelitis-optica-a-case-report
#1
George J M Hourston, Hadyn K N Kankam, Phillip Johnston
Introduction: Stress fractures are more common in the weight-bearing bones of the lower limb and are particularly prevalent in athletes. Whereas, those of the upper limb are usually reported as unique events in rare circumstances. Case Report: We present a case of a 40-year-old White British female with neuromyelitis optica (NMO) who mobilized in a wheelchair and presented to our center in April 2016 with a week-long history of a hot, swollen, and unstable right forearm...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29240231/the-issue-of-hplc-determination-of-endogenous-lipoic-acid-in-human-plasma
#2
Soňa Sechovcová, Pavla Královcová, Roman Kanďár, Karel Ventura
Lipoic acid (LA) is used extensively as a therapeutic agent for the treatment of various diseases. Many methods have been reported for the determination of LA plasma levels and its metabolites after its supplementation, but available information concerning endogenous plasma levels is still rare. Studies, which directly focused on determining the endogenous plasma levels, provided highly controversial results, less than 4.9 nmol/L or 143.7 - 197.0 nmol/L. The main aim of this study was to verify the levels of free LA in the plasma of 40 individuals (17 women, 23 men)...
December 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29204202/occult-disseminated-tuberculosis-with-holocord-longitudinally-extensive-transverse-myelitis-a-rare-phenomenon-in-a-child
#3
Gülsüm Alkan, Melike Emiroğlu, Ayşe Kartal, Harun Peru, Mustafa Koplay
Longitudinally extensive transverse myelitis (LETM) is defined as an inflammatory lesion of the spinal cord that extends to three or more segments. LETM is a commonly characteristic feature of neuromyelitis optica (NMO) or various autoimmune diseases. Manifestation of Mycobacterium tuberculosis (MTB) infection with LETM are rare and usually in the cervicothoracic spinal cord. Our patient presented with holocord LETM, so NMO was considered initially diagnosis. After in further research, MTB was diagnosed and treated successfully...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29202119/enrichment-of-retroviral-sequences-in-brain-tissue-from-patients-with-severe-demyelinating-diseases
#4
J D Kriesel, P J Bhetariya, B K Chan, T Wilson, K F Fischer
Background: Our group has used deep sequencing to identify viral RNA signatures in human brain specimens. We have previously used this method to detect HSV1, GBV-C, and measles virus sequence in brain tissue from deceased donors. Deep sequencing was performed on brain specimens from a cohort of patients who died with progressive forms of MS, revealing evidence of increased expression of some human endogenous retrovirus (HERV) domains. Objectives: Identify RNA sequences and new antigens involved in the pathogenesis of MS...
August 2017: Journal of Emerging Diseases and Virology
https://www.readbyqxmd.com/read/29201154/lymphatic-system-and-gut-microbiota-affect-immunopathology-of-neuroinflammatory-diseases-including-multiple-sclerosis-neuromyelitis-optica-and-alzheimer-s-disease
#5
Ikuo Tsunoda
Microbial infections lead to neurological damages either by direct infection in the nervous tissues or by uncontrolled immune responses (immunopathology). For example, in Zika virus infection, microcephaly can be caused by the former, i.e., direct viral infection in the brain, while Guillain-Barré syndrome (GBS) seems to be antibody-mediated immunopathology. Although a variety of factors affect immunopathology, two essential systems maintaining whole-body homeostasis had long been neglected: 1) the lymphatic system and 2) microbiota...
August 2017: Clinical & Experimental Neuroimmunology
https://www.readbyqxmd.com/read/29177719/structural-features-influential-to-enzymatic-hydrolysis-of-cellulose-solvent-based-pretreated-pinewood-and-elmwood-for-ethanol-production
#6
Behzad Satari, Keikhosro Karimi, Maryam Molaverdi
Dissolution of lignocelluloses in N-methylmorpholine-N-oxide (NMMO or NMO) at moderate conditions, e.g., 120 °C for 3 h under atmospheric pressure, and regeneration with water, is among the most effective nonderivatization pretreatment for the improvement of enzymatic hydrolysis and ethanol production. The effects of the pretreatment on two different types of wood, hardwood elm and softwood pine, were compared via physicochemical structural analyses, i.e., FTIR, XRD, SEM, TGA, and enzyme adsorption techniques, to relate their properties to the extent of enzymatic conversion...
November 24, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29172428/uniform-surface-modification-of-li2znti3o8-by-liquated-na2moo4-to-boost-the-electrochemical-performance
#7
Huan Yang, Jiyun Park, Chang-Soo Kim, Yi-Han Xu, Hui-Ling Zhu, Yong-Xin Qi, Longwei Yin, Hui Li, Ning Lun, Yu-Jun Bai
Poor ionic and electronic conductivities are the key issues to affect the electrochemical performance of Li2ZnTi3O8 (LZTO). In view of the water solubility, low melting point, good electrical conductivity, and wettability to LZTO, Na2MoO4 (NMO) was firstly selected to modify LZTO via simply mixing LZTO in NMO water solution followed by calcining the dried mixture at 750 °C for 5 h. The electrochemical performance of LZTO could be enhanced by adjusting the content of NMO, and the modified LZTO with 2 wt% NMO exhibited the most excellent rate capabilities (achieving lithiation capacities of 225...
November 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29156226/frequency-of-brain-mri-abnormalities-in-neuromyelitis-optica-spectrum-disorder-at-presentation-a-cohort-of-latin-american-patients
#8
Edgar Carnero Contentti, Vanessa Daccach Marques, Ibis Soto de Castillo, Veronica Tkachuk, Amilton Antunes Barreira, Elizabeth Armas, Edson Chiganer, Camila de Aquino Cruz, José Luis Di Pace, Javier Pablo Hryb, Carolina Lavigne Moreira, Carmen Lessa, Omaira Molina, Monica Perassolo, Arnoldo Soto, Alejandro Caride
BACKGROUND: Brain magnetic resonance imaging (BMRI) lesions were classically not reported in neuromyelitis optica (NMO). However, BMRI lesions are not uncommon in NMO spectrum disorder (NMOSD) patients. OBJECTIVE: To report BMRI characteristic abnormalities (location and configuration) in NMOSD patients at presentation. METHODS: Medical records and BMRI characteristics of 79 patients with NMOSD (during the first documented attack) in Argentina, Brazil and Venezuela were reviewed retrospectively...
November 8, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29153946/effect-of-brownian-motion-on-reduced-agglomeration-of-nanostructured-metal-oxide-towards-development-of-efficient-cancer-biosensor
#9
Suveen Kumar, Ashish, Saurabh Kumar, Shine Augustine, Santosh Yadav, Birendra Kumar Yadav, Rishi Pal Chauhan, Ajay Kumar Dewan, Bansi Dhar Malhotra
We report results of the studies relating to fabrication of nanostructured metal oxide (NMO) based cancer biosensor. With the help of 2D electroactive reduced graphene oxide (RGO), we successfully inhibited the Brownian motion of NMO that led to reduced agglomeration of NMO. The nanostructured hafnium oxide (nHfO2) was used as a model NMO. The reduced agglomeration of nHfO2 was achieved through controlled hydrothermal synthesis and investigated via nanoparticles tracking analysis (NTA). X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscope (TEM) techniques were used for phase identification as well as morphological analysis of the synthesized nanohybrid (nHfO2@RGO) material...
November 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29144890/comprehensive-analysis-of-patients-with-neuromyelitis-optica-spectrum-disorder-nmosd-combined-with-chronic-hepatitis-b-chb-infection-and-seropositive-for-anti-aquaporin-4-antibody
#10
Jia Liu, Li Xu, Zhuo-Lin Chen, Min Li, Huan Yi, Fu-Hua Peng
Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody (AQP4-Ab). Demographic, clinical, laboratory, neuroimaging, outcome, and follow-up data of the 10 patients were retrospectively analyzed...
November 16, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29141828/alternative-diagnoses-in-patients-referred-to-specialized-centers-for-suspected-ms
#11
B I Yamout, S J Khoury, N Ayyoubi, H Doumiati, M Fakhreddine, S F Ahmed, H Tamim, J Y Al-Hashel, R Behbehani, R Alroughani
OBJECTIVES: The aim of this study is to explore the frequency, type, and predictors of alternative diagnoses among patients referred with a recent diagnosis of multiple sclerosis (MS) to two specialized MS centers in the Middle East. METHODS: This is a retrospective review of a prospectively followed cohort of MS patients at 2 University specialized MS centers. All patients referred for MS were included. The final diagnosis was recorded and demographic, clinical, laboratory, electrophysiological and radiological variables were collected...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141812/neuromyelitis-optica-spectrum-disorders-in-iran
#12
Sharareh Eskandarieh, Saharnaz Nedjat, Amir Reza Azimi, Abdorreza Naser Moghadasi, Mohammad Ali Sahraian
BACKGROUND: Neuromyelitys optica spectrum disorder (NMOSD) is a rare demyelinating disease; as a result, the epidemiological data on this disorder is scarce. In this regard, the aim of this study was to estimate the prevalence, serology, and clinical features of NMOSD in Caucasian population in Tehran, Iran. METHOD: A cross sectional study was performed in Tehran from 2015 to 2016 among patients registered with NMOSD diagnosis, based on consensus criteria published in 2015...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141789/a-case-of-seropositive-neuromyelitis-optica-in-a-paediatric-patient-with-co-existing-acute-nephrotic-syndrome
#13
Thomas Volkman, Cheryl Hemingway
Neuromyelitis optica (NMO) and NMO spectrum disorder (NMOSD) is a rare relapsing autoimmune disease of the central nervous system constituting less than 1% of demyelinating diseases (Jeffery and Buncic, 1996). It preferentially affects the optic nerves and spinal cord, with the brain parenchyma generally spared. Demyelinating lesions are characterised by longitudinally extensive transverse myelitis (LETM) and often longitudinally extensive optic neuritis. Following the discovery of a novel pathogenic antibody, Aquaporin 4 in 2004 (Lennon et al...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29131884/seizures-and-encephalitis-in-myelin-oligodendrocyte-glycoprotein-igg-disease-vs-aquaporin-4-igg-disease
#14
Shahd H M Hamid, Dan Whittam, Mariyam Saviour, Amal Alorainy, Kerry Mutch, Samantha Linaker, Tom Solomon, Maneesh Bhojak, Mark Woodhall, Patrick Waters, Richard Appleton, Martin Duddy, Anu Jacob
Importance: Antibodies to myelin oligodendrocyte glycoprotein IgG (MOG-IgG) are increasingly detected in patients with non-multiple sclerosis-related demyelination, some of whom manifest a neuromyelitis optica (NMO) phenotype. Cortical involvement, encephalopathy, and seizures are rare in aquaporin 4 antibody (AQP4-IgG)-related NMO in the white European population. However, the authors encountered several patients with seizures associated with MOG-IgG disease. Objective: To compare incidence of seizures and encephalitis-like presentation, or both between AQP4-IgG-positive and MOG-IgG-positive patients...
November 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29123400/comparison-of-spontaneous-brain-activity-revealed-by-regional-homogeneity-in-aqp4-igg-neuromyelitis-optica-optic-neuritis-versus-mog-igg-optic-neuritis-patients-a-resting-state-functional-mri-study
#15
Junqing Wang, Yuan Tian, Yi Shao, Hui Feng, Limin Qin, Weiwei Xu, Hongjuan Liu, Quangang Xu, Shihui Wei, Lin Ma
Objective: Many previous studies have demonstrated that neuromyelitis optica (NMO) patients have abnormalities of brain anatomy and function. However, differences in spontaneous brain activity between myelin oligodendrocyte glycoprotein (MOG)-IgG ON and aquaporin 4(AQP4)-neuromyelitis optica-optic neuritis (ON) remain unknown. In the current study, we investigated the brain neural homogeneity in MOG-IgG ON versus AQP4-IgG NMO-ON subjects by regional homogeneity (ReHo) method using magnetic resonance imaging (MRI)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29118581/complexity-and-wide-range-of-neuromyelitis-optica-spectrum-disorders-more-than-typical-manifestations
#16
REVIEW
Jinming Han, Meng-Ge Yang, Jie Zhu, Tao Jin
Neuromyelitis optica (NMO), considered to be mediated by autoantibodies, often cause severely disabling disorders of the central nervous system, and predominantly cause optic nerve damage and longitudinally extensive transverse myelitis. Remarkable progress has been made in deciphering NMO pathogenesis during the past decade. In 2015, the International Panel for NMO Diagnosis proposed the unifying term "NMO spectrum disorders" (NMOSD) and the updated NMOSD criteria reflects a wide range of disease and maintains reasonable specificity...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29114368/recurrent-isolated-optic-neuritis-a-study-on-22-patients
#17
Mahsa Arzani, Mohammad Ali Sahraian, Hamed Rezaei, Abdorreza Naser Moghadasi
Background: Isolated relapsing optic neuropathy is a recurrent painful optic nerve inflammation without any sign of other demyelinating diseases such as multiple sclerosis (MS) or neuromyelitis optica (NMO) spectrum disorders, and the attacks are purely responsive to steroid therapy. Methods: Recurrent isolated optic neuritis (RION) was diagnosed in patients who presented with at least two disseminating episodes of optic neuritis, and negative clinical, para-clinical, and radiological features of the demyelinating, infiltrative and vasculitis disorders involving optic nerve...
July 6, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29107207/association-of-serum-gamma-glutamyltransferase-and-c-reactive-proteins-with-neuromyelitis-optica-and-multiple-sclerosis
#18
Yaqing Shu, Rui Li, Wei Qiu, Yanyu Chang, Xiaobo Sun, Ling Fang, Chen Chen, Yu Yang, Zhengqi Lu, Xueqiang Hu, Allan G Kermode
BACKGROUND: Many studies have demonstrated that serum gamma glutamyltransferase (GGT) within normal range might be an early marker of oxidative stress. However the role of GGT in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unknown. METHODS: We assessed the correlations among GGT and C-reactive protein (CRP) levels, as well as clinical characteristics of NMO and MS. Serum GGT and CRP levels were measured in 106 NMO patients, 87 MS patients, 79 patients with non-inflammatory neurological diseases (Parkinson disease) and 80 healthy controls (HC)...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29102045/-myelitis-as-a-differential-diagnosis-of-spinal-cord-tumors
#19
P Vermersch, O Outteryck, D Ferriby, H Zéphir
BACKGROUND AND PURPOSE: Myelitis is common, related to multiple aetiologies and constitute in some cases a differential diagnosis for spinal cord tumors. Our objective was to review the clinical and paraclinical aspects of the main aetiologies of myelitis. METHODS: These aetiologies will be reviewed based on data not only from the scientific literature but also from our personal experience reported in different cohorts of patients. RESULTS: Multiple sclerosis is the main cause of partial myelitis in young adults...
November 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29100047/prevalence-of-neuromyelitis-optica-spectrum-disorder-in-the-multi-ethnic-penang-island-malaysia-and-a-review-of-worldwide-prevalence
#20
Jyh Yung Hor, Thien Thien Lim, Yuen Kang Chia, Yee Ming Ching, Chun Fai Cheah, Kenny Tan, Han Bing Chow, Masita Arip, Gaik Bee Eow, P E Samuel Easaw, M Isabel Leite
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) occurs worldwide in all ethnicities. Recently, population-based studies have shown that NMOSD is more common among non-White populations. There is scarce data about NMOSD prevalence in South East Asian populations. METHODS: (1) A population-based study was undertaken to estimate NMOSD prevalence in the multi-ethnic Penang Island, Malaysia, comprising Chinese, Malays, and Indians. Medical records of NMOSD patients followed up at the Penang General Hospital (the neurology referral centre in Penang Island) were reviewed...
October 21, 2017: Multiple Sclerosis and related Disorders
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