keyword
https://read.qxmd.com/read/38546930/understanding-the-genetic-and-non-genetic-interconnections-in-the-aetiology-of-isolated-congenital-heart-disease-an-updated-review-part-1
#1
REVIEW
Jyoti Maddhesiya, Bhagyalaxmi Mohapatra
PURPOSE OF REVIEW: Congenital heart disease (CHD) is the most frequently occurring birth defect. Majority of the earlier reviews focussed on the association of genetic factors with CHD. A few epidemiological studies provide convincing evidence for environmental factors in the causation of CHD. Although the multifactorial theory of gene-environment interaction is the prevailing explanation, explicit understanding of the biological mechanism(s) involved, remains obscure. Nonetheless, integration of all the information into one platform would enable us to better understand the collective risk implicated in CHD development...
March 28, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38544880/advances-in-fetal-cardiac-imaging-and-intervention
#2
REVIEW
Nathaniel Barber, Lindsay Freud
The field of fetal cardiology has evolved significantly in recent years. This review focuses on specific advances in fetal cardiac imaging and intervention that are increasingly used in clinical practice. On the imaging frontier, updated screening guidelines and artificial intelligence hold promise for improving prenatal detection of congenital heart disease. Advances in ultrasound technology and magnetic resonance imaging techniques have enabled greater diagnostic and prognostic accuracy of fetal heart disease from the first to third trimesters, and maternal hyperoxygenation can offer additional physiological insights...
February 2024: CJC Pediatr Congenit Heart Dis
https://read.qxmd.com/read/38509443/racial-disparities-in-breastfeeding-rates-in-patients-with-heart-disease
#3
JOURNAL ARTICLE
Ayamo G Oben, Christina T Blanchard, Ashton Robinson, Isabel Girling, Joanna M Joly, Marc Cribbs, Alan Tita, Brian Casey, Rachel Sinkey
OBJECTIVE: To evaluate racial disparities in breastfeeding rates in patients with heart disease. STUDY DESIGN: Retrospective cohort of pregnant patients with maternal cardiac disease managed by a Cardio-Obstetrics program. Patients self-identifying as Non-Hispanic Black (NHB) and Non-Hispanic White (NHW), who attended ≥ 1 prenatal visit at the Cardio-Obstetrics Program and delivered at the same hospital between March 2015 and June 2019 were included...
March 20, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38505753/reprogramming-of-the-developing-heart-by-hif1a-deficient-sympathetic-system-and-maternal-diabetes-exposure
#4
JOURNAL ARTICLE
Hana Kolesova, Petra Hrabalova, Romana Bohuslavova, Pavel Abaffy, Valeria Fabriciova, David Sedmera, Gabriela Pavlinkova
INTRODUCTION: Maternal diabetes is a recognized risk factor for both short-term and long-term complications in offspring. Beyond the direct teratogenicity of maternal diabetes, the intrauterine environment can influence the offspring's cardiovascular health. Abnormalities in the cardiac sympathetic system are implicated in conditions such as sudden infant death syndrome, cardiac arrhythmic death, heart failure, and certain congenital heart defects in children from diabetic pregnancies...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38502815/breastfeeding-practices-in-patients-with-heart-disease-stratified-by-area-deprivation-index
#5
JOURNAL ARTICLE
Isabel C Collins, Christina T Blanchard, Meghan Tipre, Ayamo Oben, Ashton Robinson, Tavonna Kako, Joanna M Joly, Marc G Cribbs, Brian Casey, Alan Tita, Rachel Sinkey
Objective: We sought to evaluate breastfeeding (BF) practices in patients with maternal cardiac disease (MCD) stratified by area deprivation index (ADI) to identity communities at risk. Study Design: Retrospective cohort of patients managed by the University of Alabama at Birmingham (UAB) Cardio-Obstetrics Program. Patients were included if they had ≥1 prenatal visit with the Cardio-Obstetrics team, delivered at UAB, and had a street address on file. The primary outcome was BF rate at hospital discharge...
March 19, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38497437/predicting-high-risk-fetal-cardiac-disease-anticipated-to-need-immediate-postnatal-stabilization-and-intervention-with-planned-pediatric-cardiac-operating-room-delivery
#6
REVIEW
Amol Moray, Proscovia M Mugaba, Chloe Joynt, Angela McBrien, Luke G Eckersley, Ernest Phillipos, Paula Holinski, Lindsay Ryerson, James Yashu Coe, Sujata Chandra, Billy Wong, Michele Derbyshire, Maria Lefebvre, Mohammed Al Aklabi, Lisa K Hornberger
BACKGROUND: Distances between delivery and cardiac services can make the care of fetuses with cardiac disease at risk of acute cardiorespiratory instability at birth a challenge. In 2013 we implemented a fetal echocardiography-based algorithm targeting fetuses considered high risk for acute cardiorespiratory instability at ≤2 hours of birth for delivery in our pediatric cardiac operating room of our children's hospital, and, herein, examine our experience. METHODS AND RESULTS: We reviewed maternal and postnatal medical records of all fetuses with cardiac disease encountered January 2013 to March 2022 considered high risk for acute cardiorespiratory instability...
March 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38495666/the-impact-of-pregnancy-in-patients-with-thoracic-aortic-disease-epidemiology-risk-assessment-and-management-considerations
#7
REVIEW
Valeria E Duarte, Jessica N Richardson, Michael N Singh
Thoracic aortic disease (TAD) poses substantial risks during pregnancy, particularly for women with genetic conditions such as Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome. This review examines the epidemiology, risk assessment, and management of TAD in pregnancy. Preconception counseling is vital considering the hereditary nature of TAD and potential pregnancy-related complications. Genetic testing and imaging surveillance aid in risk assessment. Medical management, including beta-blockade and strict blood pressure control, is essential throughout pregnancy...
2024: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/38495662/high-risk-congenital-heart-disease-in-pregnancy
#8
REVIEW
Saurabh Rajpal, Carla P Rodriguez
High-risk congenital heart disease (CHD) in pregnancy presents a complex clinical challenge. With improved medical care and increased survival rates, a growing population of adults with complex CHD are surviving to adulthood, including women of reproductive age. This chapter focuses on risk stratification and management of pregnant women with high-risk CHD, emphasizing the importance of considering both anatomical and physiological complexity. Maternal physiological changes, such as blood volume increase, cardiac output changes, and alterations in vascular resistance, can significantly impact high-risk CHD patients...
2024: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/38495654/an-overview-of-arrhythmias-in-pregnancy
#9
REVIEW
Kamala P Tamirisa, Estefania Oliveros, Shweta Paulraj, Adriana C Mares, Annabelle Santos Volgman
Cardiovascular disease significantly jeopardizes pregnancies in the United States, impacting 1% to 4% of pregnancies annually. Among complications, cardiac arrhythmias are prevalent, posing concerns for maternal and fetal health. The incidence of arrhythmias during pregnancy is rising, partly due to advances in congenital heart surgery and a growing population of women with structural heart disease. While most arrhythmias are benign, the increasing prevalence of more serious arrhythmias warrants a proactive approach...
2024: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/38492326/impaired-ischemia-reperfusion-responses-in-the-hearts-of-aged-male-and-female-offspring-of-obese-rats
#10
JOURNAL ARTICLE
Carlos A Ibáñez, Francisco Correa, Gabriela Lira-León, Luis A Reyes-Castro, Francisco Javier Roldán, Alejandro Silva-Palacios, Mabel Buelna-Chontal, Guadalupe L Rodríguez-González, Peter W Nathanielsz, Cecilia Zazueta, Elena Zambrano
Maternal obesity predisposes offspring (F1) to cardiovascular disease. To evaluate basal heart function and ischemia-reperfusion (IR) responses in F1 males and females of obese mothers, female Wistar rats (F0) were fed chow or an obesogenic (MO) diet from weaning through pregnancy and lactation. Non-sibling F1 males and females were weaned to chow at postnatal day (PND) 21 and euthanized at PND 550. Offspring of MO mothers (MOF1) rarely survive beyond PND 650. Hearts were immediately isolated from euthanized F1s and subjected to 30 min ischemia with 20 min reperfusion...
March 15, 2024: Archives of Medical Research
https://read.qxmd.com/read/38489018/prenatal-detection-rates-for-congenital-heart-disease-using-abnormal-obstetrical-screening-ultrasound-alone-as-indication-for-fetal-echocardiography
#11
JOURNAL ARTICLE
Sanjay Vepa, Mubarika Alavi, Weilu Wu, Julie Schmittdiel, Lisa J Herrinton, Kavin Desai
OBJECTIVE: To determine the live born prenatal detection rate of significant congenital heart disease (CHD) in a large, integrated, multi-center community-based health system using a strategy of referral only of patients with significant cardiac abnormalities on obstetrical screening ultrasound for fetal echocardiography. Detection rates were assessed for screening in both radiology and maternal fetal medicine (MFM). The impact on fetal echocardiography utilization was also assessed. METHODS: This was a retrospective cohort study using an electronic health record, outside claims databases and chart review to determine all live births between 2016 and 2020 with postnatally confirmed sCHD that were prenatally detectable and resulted in cardiac surgery, intervention, or death within 1 year...
March 15, 2024: Prenatal Diagnosis
https://read.qxmd.com/read/38485554/maternal-and-neonatal-outcomes-in-women-with-congenital-heart-disease-a-nationwide-population-based-study
#12
JOURNAL ARTICLE
Kuan-Miao Lin, Yun-Hsuan Yang, Chuan-Pin Lee, Ko-Jung Chen, Yao-Hsu Yang, Jiunn-Ming Sheen, Shao-Ju Chien
BACKGROUND: We evaluated the outcomes of pregnancy in women with congenital heart disease (CHD) and their offspring in Taiwan. We also investigated how different severity levels may influence the outcomes. METHODS: We used data (2009-2017) from the Birth Certificate Application database in Taiwan, which is linked to the National Health Insurance Research Database and Taiwan Maternal and Child Health Database. We identified 2990 women with CHD who had 4227 births...
March 13, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38479548/maternal-exercise-preserves-offspring-cardiovascular-health-via-oxidative-regulation-of-the-ryanodine-receptor
#13
JOURNAL ARTICLE
Kelsey M Pinckard, Elisa Félix-Soriano, Shanna Hamilton, Radmila Terentyeva, Lisa A Baer, Katherine R Wright, Drew Nassal, Joao Victor Esteves, Eaman Abay, Vikram K Shettigar, Mark T Ziolo, Thomas J Hund, Loren E Wold, Dmitry Terentyev, Kristin I Stanford
OBJECTIVE: The intrauterine environment during pregnancy is a critical factor in the development of obesity, diabetes, and cardiovascular disease in offspring. Maternal exercise prevents the detrimental effects of a maternal high fat diet on the metabolic health in adult offspring, but the effects of maternal exercise on offspring cardiovascular health have not been thoroughly investigated. METHODS: To determine the effects of maternal exercise on offspring cardiovascular health, female mice were fed a chow (C; 21% kcal from fat) or high-fat (H; 60% kcal from fat) diet and further subdivided into sedentary (CS, HS) or wheel exercised (CW, HW) prior to pregnancy and throughout gestation...
March 11, 2024: Molecular Metabolism
https://read.qxmd.com/read/38478508/causes-of-death-among-women-of-reproductive-age-during-the-war-in-tigray-ethiopia
#14
JOURNAL ARTICLE
Hiluf Ebuy Abraha, Hale Teka, Awol Yemane Legesse, Mohamedawel Mohamedniguss Ebrahim, Mache Tsadik, Girmatsion Fisseha, Bereket Berhe, Brhane Ayele, Gebrehaweria Gebrekurstos, Tesfit Gebremeskel, Tsega Gebremariam, Martha Yemane Hadush, Tigist Hagos, Abraha Gebreegziabher, Kibrom Muez, Haile Tesfay, Hagos Godefay, Afework Mulugeta
BACKGROUND: In resource-limited countries with weak healthcare systems, women of reproductive age are particularly vulnerable during times of conflict. In Tigray, Ethiopia, where a war broke out on 04 November 2020, there is a lack of information on causes of death (CoD) among women of reproductive age. This study aims to determine the underlying CoD among women of reproductive age during the armed conflict in Tigray. METHODS: This community-based survey was carried out in six Tigray zones, excluding the western zone for security reasons...
2024: PloS One
https://read.qxmd.com/read/38477180/assessment-of-fetal-cardiac-functions-in-pregnant-women-with-anemia-prospective-case-control-study
#15
JOURNAL ARTICLE
Z Agaoglu, A Tanacan, U Gurbuz, M Ozturk Agaoglu, M Haksever, G Okutucu, O Kara, D Sahin
OBJECTIVE: To compare the fetal cardiac functions between pregnant women with iron deficiency anemia (IDA) and healthy controls. METHODS: This single-center, prospective, case-control study was conducted at a tertiary hospital. A total of 150 patients, including 50 patients with IDA and 100 healthy pregnant women at 30-34 weeks of gestation, were included in the study. Of the patients with anemia, 20 had mild anemia, 18 had moderate anemia, and 12 had severe anemia...
March 13, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38477164/first-trimester-screening-identifies-maternal-cardiac-maladaptation-at-mid-gestation
#16
JOURNAL ARTICLE
M Charakida, E Gibbone, I Huluta, A Syngelaki, A Wright, K H Nicolaides
BACKGROUND: First, a logistic regression model, based on maternal demographic characteristics and medical history and blood pressure at 11-13 weeks' gestation, can identify about 70% of women who develop future chronic hypertension (CH) in the three years following pregnancy, at screen positive rate of 10%. Second, at mid-gestation women who subsequently develop hypertensive disorders of pregnancy (HDP) have increased peripheral vascular resistance and mild cardiac functional and morphological alterations and these cardiovascular abnormalities persist for at least 2 years after delivery...
March 13, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38477161/b-flow-spatiotemporal-image-correlation-m-mode-ultrasound-provides-novel-method-to-quantify-spiral-artery-remodeling-during-normal-human-pregnancy
#17
JOURNAL ARTICLE
O M Turan, Y Liang, B Kelley, S Turan, G J Pepe, E D Albrecht
OBJECTIVES: During human pregnancy placental extravillous trophoblasts replace the vascular smooth muscle and elastic tissue within the walls of the uterine spiral arteries, thereby remodeling these arteries into distensible low resistance vessels to promote placental perfusion. The present study, determined whether B-flow/ spatio-temporal image correlation (STIC) M-mode ultrasonography provides an in vivo imaging method to digitally quantify spiral artery luminal distensibility, as a physiological index of spiral artery remodeling, during advancing stages of normal human pregnancy...
March 13, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38475689/progress-in-the-application-of-echocardiography-in-neonatal-pulmonary-hypertension
#18
REVIEW
Zehang Hu, Shumin Fan
Purpose: This review aims to overview the use of echocardiography in diagnosing neonatal pulmonary hypertension, assessing cardiac function, and understanding the significance and limitations of various parameters in clinical practice. Materials and methods: Advancements in echocardiography for diagnosing and assessing neonatal pulmonary hypertension, evaluating cardiac function, monitoring treatment effectiveness, and predicting prognosis are discussed. Results: Echocardiography is a pivotal tool for diagnosing and managing neonatal pulmonary hypertension...
December 2024: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/38467793/postpartum-and-interpregnancy-care-of-women-with-a-history-of-hypertensive-disorders-of-pregnancy
#19
REVIEW
Takafumi Ushida, Sho Tano, Kenji Imai, Seiko Matsuo, Hiroaki Kajiyama, Tomomi Kotani
Hypertensive disorders of pregnancy (HDP) are common complications associated with maternal and neonatal morbidity and mortality worldwide. Insights gained from long-term cohort studies have revealed that women with a history of HDP are predisposed to recurrent HDP in subsequent pregnancies and face heightened risks for cardiovascular and metabolic diseases later in life. Pregnancy is a unique condition that overloads maternal cardiac and metabolic functions, and is recognized as a "maternal stress test" for future cardiovascular and metabolic diseases...
March 11, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38460824/pregnancy-related-cardiac-outcomes-among-patients-with-congenital-heart-disease-after-formalization-of-a-cardio-obstetrics-program
#20
JOURNAL ARTICLE
Jennifer A McCoy, Yuli Y Kim, Annique Nyman, Lisa D Levine
BACKGROUND: We sought to examine pregnancy outcomes in patients with congenital heart disease (CHD) before and after the establishment of formal Cardio-Obstetrics collaboration between adult CHD and Maternal Fetal Medicine (MFM) programs. METHODS: We conducted a retrospective cohort study of pregnant CHD patients from 2002-2020 at a single urban academic institution in the US. We included patients with a singleton gestation who continued a pregnancy beyond 20 weeks...
March 7, 2024: American journal of obstetrics & gynecology MFM
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