keyword
https://read.qxmd.com/read/38523891/pregnancy-and-inflammatory-bowel-disease-a-special-combination
#1
REVIEW
Viviana Parra Izquierdo, Carolina Pavez Ovalle, Valeria Costa, Ana María Leguízamo, Juan Sebastián Frías Ordoñez, Albis Hani
Inflammatory bowel disease (IBD) comprises a spectrum of chronic immune-mediated diseases that affect the gastrointestinal tract. Onset typically occurs in early adulthood. The incidence of this disease has increased worldwide. Its prevalence has increased in Colombia and occurs predominantly in women. Considering that this disease is not curable, the main objective of management is to achieve remission. Many women are affected by IBD during different stages of their lives, including their reproductive life, pregnancy, and menopause...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38495524/association-between-early-life-exposure-to-agriculture-biodiversity-and-green-space-and-risk-of-inflammatory-bowel-disease-a-population-based-cohort-study
#2
JOURNAL ARTICLE
Manasi Agrawal, Anne V Hansen, Jean-Frederic Colombel, Tine Jess, Kristine H Allin
BACKGROUND: Specific pollutants and environmental exposures are implicated in modulating inflammatory bowel disease (IBD) risk. However, the role of environmental exposures, particularly during the early life period, towards IBD risk, has not been systematically evaluated. METHODS: We conducted a nationwide population-based cohort study during the study period extending from January 1, 1995, to September 1, 2020, using cross-linked Danish registers, maps, and inventories to ascertain the impact of agricultural land use, biodiversity, green space, urban space, blue space, and normalized difference vegetation index during pregnancy and the first two years of life on IBD, Crohn's disease (CD), and ulcerative colitis (UC) risk, using adjusted Cox proportional hazards regression analyses...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38493274/low-dose-aspirin-use-does-not-increase-disease-activity-in-pregnant-patients-with-inflammatory-bowel-disease
#3
JOURNAL ARTICLE
Chelsea A DeBolt, Zoë S Gottlieb, Manasa G Rao, Shaelyn Johnson, Patricia Rekawek, Richa Deshpande, Rachel Meislin, Jill Berkin, Angela Bianco, Maria Teresa Mella, Marla C Dubinsky
BACKGROUND: The adverse effects of non-steroidal anti-inflammatory (NSAID) drugs on the gastrointestinal system are well recognized, but the effect of NSAID use on disease activity patients with inflammatory bowel disease (IBD) remains unresolved. Low-dose aspirin (LDA) is recommended for all pregnant patients with risk factors for developing preeclampsia, including autoimmune conditions. As recognition of risk factors for preeclampsia improves, the preventative use of LDA is likely to increase...
March 16, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38466213/mirikizumab-omvoh-for-ulcerative-colitis
#4
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2024: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/38439613/inflammatory-bowel-disease-and-breastfeeding-a-narrative-review
#5
JOURNAL ARTICLE
Tedi Hoxha, Michael Youssef, Vivian Huang, Parul Tandon
Inflammatory bowel disease (IBD) frequently affects women of childbearing age who may consider breastfeeding. Although breastfeeding has numerous benefits, there remain concerns regarding the safety of breastfeeding among women with IBD. Breastfeeding is important in developing the immune system of infants and has been shown to protect against the development of IBD. The risk of developing an increase in disease activity postpartum is the same regardless of breastfeeding status. Most IBD medications are also considered safe in breastfeeding and have no major risks to infants...
March 4, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38376076/does-surgery-prior-to-pregnancy-in-women-with-inflammatory-bowel-disease-increase-the-risk-of-adverse-maternal-and-fetal-outcomes-a-danish-national-cohort-study
#6
JOURNAL ARTICLE
Sonia Friedman, Jan Nielsen, Niels Qvist, Torben Knudsen, Jens Kjeldsen, Anne-Sofie Sønnichsen-Dreehsen, Bente Mertz Nørgård
INTRODUCTION: Up to 15% of women with Crohn's disease (CD) or ulcerative colitis (UC) have bowel surgery prior to pregnancy and there is little data on pregnancy outcomes in this population. We aimed to assess maternal/fetal outcomes in women with CD and UC surgeries prior to pregnancy. METHODS: In this nationwide study, we included all pregnancies in women with CD or UC from 1997-2022 and examined 6 categories of CD and UC surgeries prior to pregnancy. We used multilevel logistic regression to compute crude and adjusted odds ratios [aOR] with 95% confidence intervals [95% CI] for the risk of pregnancy and offspring complications in women who did, versus did not, have surgery prior to pregnancy...
February 20, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38347433/tofacitinib-use-in-ulcerative-colitis-an-expert-consensus-for-day-to-day-clinical-practice
#7
JOURNAL ARTICLE
Rupa Banerjee, Vishal Sharma, Rajendra Patel, Anuraag Jena, Partha Pal, Nalini Raghunathan, Ajay Kumar, Ajit Sood, Amarender S Puri, Bhabhadev Goswami, Devendra Desai, Dhanush Mekala, G N Ramesh, G V Rao, Kiran Peddi, Mathew Philip, Manu Tandon, Shobna Bhatia, Shubhankar Godbole, Sumit Bhatia, Uday C Ghoshal, Usha Dutta, Vandana Midha, V G Mohan Prasad, D Nageshwar Reddy
Rising number of inflammatory bowel disease (IBD) cases in developing countries necessitate clear guidance for clinicians for the appropriate use of advanced therapies. An expert consensus document was generated to guide the usage of tofacitinib, a Janus kinase inhibitor, in ulcerative colitis. Tofacitinib is a useful agent for the induction and maintenance of remission in ulcerative colitis. It can be used in the setting of biological failure or even steroid-dependent and thiopurine refractory disease...
February 12, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38330216/thrombocytosis-and-transaminitis-in-infants-born-to-women-with-inflammatory-bowel-disease-is-associated-with-exposure-to-maternal-inflammation-in-utero
#8
JOURNAL ARTICLE
Ralley Prentice, Emma Flanagan, Emily Wright, Winita Hardikar, Alyson Ross, Megan Burns, Lani Prideaux, William Connell, Miles Sparrow, Peter De Cruz, Mark Lust, Rimma Goldberg, Sara Vogrin, Tessa Greeve, Sally Bell
BACKGROUND: Despite reassuring clinical safety data, thrombocytosis, anemia, lymphopenia, and liver function derangements have been observed in infants born to women with inflammatory bowel disease (IBD) treated with thiopurines and biologics. We aimed to define the prevalence, course, associations, and clinical impact of hematological and biochemical abnormalities in such infants. METHODS: This multicenter prospective cohort study assessed clinical, hematologic, and biochemical outcomes of infants exposed to thiopurines or biologics in utero for management of maternal IBD...
February 8, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38317692/normal-infant-immunologic-assessment-and-uneventful-live-rotavirus-vaccination-despite-continuous-tofacitinib-exposure-in-utero-and-during-breastfeeding
#9
JOURNAL ARTICLE
Kenneth Ernest-Suarez, Luis E Murguía-Favela, Kerri L Novak, Remo Panaccione, Cora Constantinescu, Cynthia H Seow
BACKGROUND: Janus kinase (JAK) inhibitors are effective for the treatment of inflammatory bowel disease (IBD). However, this class of medications is not recommended during pregnancy or breastfeeding based on animal data suggesting teratogenesis and recent reports of transmammary transfer after maternal ingestion, raising concerns for immune system development in babies exposed to these drugs. METHODS: We present the case of a patient with IBD treated with a JAK inhibitor who decided to continue the medication throughout her pregnancy and during breastfeeding...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38314178/the-fundamentals-of-inflammatory-bowel-disease-management-in-pregnancy-a-practical-review-for-the-gastroenterologist
#10
REVIEW
Elizabeth Squirell, Susanna Meade, Yvette Leung
This narrative review explores the management of Inflammatory Bowel Disease (IBD) during pregnancy, emphasizing its unique challenges to maternal and fetal health, particularly within the Canadian Gastroenterology setting. Seven key principles are highlighted: 1) Preconception counselling, aiming for steroid-free remission confirmed by objective markers, should be routine for female IBD patients. 2) Medication safety, with an eye to future pregnancies, should be addressed upon initiation. Methotrexate and small molecules are contraindicated during pregnancy, while most 5-ASA therapies, biologics, and thiopurines can be continued throughout pregnancy and breastfeeding...
February 2024: Journal of the Canadian Association of Gastroenterology
https://read.qxmd.com/read/38292667/placental-transfer-of-tofacitinib-in-the-ex-vivo-dual-side-human-placenta-perfusion-model
#11
JOURNAL ARTICLE
Gaby A M Eliesen, Milou Fransen, Hedwig van Hove, Petra H H van den Broek, Rick Greupink
Tofacitinib is a small molecule Janus kinase (JAK) inhibitor, introduced to the European market in 2017, for the treatment of rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. In the treatment of women with autoimmune diseases, pregnancy is a relevant issue, as such diseases typically affect women in their reproductive years. Currently, there is limited data on the use of tofacitinib during pregnancy. To estimate the extent of placental transfer in the absence of clinical data, we conducted ex vivo dual-side perfused human placental cotyledon perfusions...
2024: Current research in toxicology
https://read.qxmd.com/read/38267826/pregnancy-outcomes-in-the-ozanimod-clinical-development-program-in-patients-with-ulcerative-colitis-crohn-s-disease-and-relapsing-multiple-sclerosis
#12
JOURNAL ARTICLE
Marla C Dubinsky, Lorna Charles, Krzysztof W Selmaj, Giancarlo Comi, Anthony Krakovich, Melissa Rosen, C Janneke van der Woude, Uma Mahadevan
No abstract text is available yet for this article.
January 24, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38206331/preterm-birth-and-in-utero-exposure-to-corticosteroids-are-associated-with-increased-infection-risk-in-children-of-mothers-with-ibd
#13
JOURNAL ARTICLE
Thea Vestergaard, Ida Holm Meiltoft, Mette Julsgaard, Rikke Bek Helmig, Sonia Friedman, Jens Kelsen
BACKGROUND: Corticosteroids, thiopurines, and biologics may come into play during pregnancy in women with inflammatory bowel disease and potentially impact the developing fetal immune system. We aimed to assess the risk of serious infections in children stratified by in utero exposure to biologics and immunomodulators or concomitant treatment with corticosteroids. METHODS: All singleton IBD pregnancies between 2008 and 2022 at a tertiary IBD center in Denmark were included...
January 11, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38141224/early-onset-sepsis-and-lobar-pneumonia-in-a-newborn-exposed-in-utero-to-ustekinumab-and-azathioprine
#14
JOURNAL ARTICLE
Cæcilie Skejø, Signe Thim, Anna Sellmer, Mette Julsgaard
No abstract text is available yet for this article.
December 23, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38123972/early-life-exposures-and-the-microbiome-implications-for-ibd-prevention
#15
REVIEW
Lin Zhang, Manasi Agrawal, Siew C Ng, Tine Jess
The early-life period is one of microbiome establishment and immune maturation. Early-life exposures are increasingly being recognised to play an important role in IBD risk. The composition of functions of the gut microbiome in the prenatal, perinatal, and postnatal period may be crucial towards development of health or disease, including IBD, later in life. We herein present a comprehensive summary of the interplay between early-life factors and microbiome perturbations, and their association with risk of IBD...
December 12, 2023: Gut
https://read.qxmd.com/read/38038665/impact-of-maternal-smoking-offspring-smoking-and-genetic-susceptibility-on-crohn-s-disease-and-ulcerative-colitis
#16
JOURNAL ARTICLE
Linmin Hu, Siqing Wu, Yuelong Shu, Kai Su, Chunliang Wang, Danni Wang, Qiangsheng He, Xinyu Chen, Wenjing Li, Ningning Mi, Peng Xie, Jinyu Zhao, Shiyong Zhang, Jinqiu Yuan, Jianbang Xiang, Bin Xia
BACKGROUND AND AIMS: The long-term impact of maternal smoking during pregnancy (MSDP) on adult offspring's risk of Crohn's disease (CD) and ulcerative colitis (UC) remains uncertain. Our study aims to investigate the individual and combined effects of early life exposure (MSDP), offspring personal behavior (smoking), and genetic risk on the development of CD and UC in adult offspring. METHODS: We conducted a prospective cohort study using UK Biobank data, including 334,083 participants recruited between 2006-2010, with follow-up until December 31, 2021...
December 1, 2023: Journal of Crohn's & Colitis
https://read.qxmd.com/read/38018475/role-of-ustekinumab-in-treatment-of-ulcerative-colitis-a-narrative-review
#17
REVIEW
Mauro Grova, Alessandro Vitello, Mariella Mannino, Angelo Casà, Sara Renna, Fabio Salvatore Macaluso, Ambrogio Orlando
The therapeutic armamentarium for gastroenterologists in treating ulcerative colitis (UC) has been rapidly growing since the introduction of monoclonal antibodies directed against anti-TNFs. Ustekinumab is a monoclonal antibody binding the shared p40 subunit of IL-12 and IL-23, and the inhibition of these two cytokines, implicated in host response to microbial pathogens, has demonstrated clinical efficacy in different immune-mediated diseases, including moderate-to-severe UC. This narrative review summarizes the newest clinical evidence regarding the efficacy, effectiveness and safety of ustekinumab in moderate-to-severe UC, including specific situations (pregnancy, breastfeeding, elderly/pediatric populations, extraintestinal manifestations, acute severe UC, pouchitis and dual biological therapy)...
November 29, 2023: Immunotherapy
https://read.qxmd.com/read/37983118/etrasimod-velsipity-for-ulcerative-colitis
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2023: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/37921331/early-life-hygiene-related-factors-and-risk-of-inflammatory-bowel-disease-a-scandinavian-birth-cohort-study
#19
JOURNAL ARTICLE
Annie Guo, Malin Östensson, Ketil Størdal, Johnny Ludvigsson, Karl Mårild
BACKGROUND: We aimed to investigate whether early-life hygiene-related factors influenced the risk of inflammatory bowel disease (IBD) in a Scandinavian population and test the association's consistency across cohorts. METHODS: This study followed 117 493 participants in the All Babies in Southeast Sweden study and the Norwegian Mother, Father, and Child Cohort Study. IBD diagnoses were defined by national registers. Comprehensive data on hygiene-related exposures, such as having pets, rural living, daycare attendance, and siblings, were retrieved from questionnaires administered from pregnancy until child's age of 36 months...
October 31, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37900441/newly-diagnosed-ulcerative-colitis-in-the-third-trimester-a-case-report
#20
Arley K Rodriguez, Sean M Muir, Lindsay Tjiattas-Saleski
Ulcerative colitis is a chronic inflammatory bowel disease that results in continuous colon inflammation. It is uncommonly diagnosed during pregnancy, and if quiescent before pregnancy, becomes active very rarely. Current literature has found that amelioration of the disease can be common during the second and third trimesters. However, if ulcerative colitis is active, it has the potential to result in premature delivery and low birth weight. This case focuses on a rare presentation of primary ulcerative colitis diagnosed in a 22-year-old multiparous patient to highlight the importance of a comprehensive differential diagnosis in pregnant patients with seemingly benign symptomatology...
September 2023: Curēus
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