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JOURNAL ARTICLE
Thea Vestergaard, Ida Holm Meiltoft, Mette Julsgaard, Rikke Bek Helmig, Sonia Friedman, Jens Kelsen
BACKGROUND: Corticosteroids, thiopurines, and biologics may come into play during pregnancy in women with inflammatory bowel disease and potentially impact the developing fetal immune system. We aimed to assess the risk of serious infections in children stratified by in utero exposure to biologics and immunomodulators or concomitant treatment with corticosteroids. METHODS: All singleton IBD pregnancies between 2008 and 2022 at a tertiary IBD center in Denmark were included...
January 11, 2024: Inflammatory Bowel Diseases
#22
JOURNAL ARTICLE
Elena Sonnenberg, Britta Siegmund
Inflammatory bowel disease (IBD) is often diagnosed in young adults. Starting a family is an important step in life and can be further complicated by Crohn's disease. Therefore, family planning should be discussed with every patient early in the disease course. Counseling about the importance of disease remission and the safety of IBD medication during pregnancy can ameliorate the pregnancy outcome. Active disease during pregnancy can lead to adverse pregnancy outcomes such as preterm birth and low birthweight...
January 2024: Deutsche Medizinische Wochenschrift
#23
JOURNAL ARTICLE
Cæcilie Skejø, Signe Thim, Anna Sellmer, Mette Julsgaard
No abstract text is available yet for this article.
December 23, 2023: Inflammatory Bowel Diseases
#24
REVIEW
Lin Zhang, Manasi Agrawal, Siew C Ng, Tine Jess
The early-life period is one of microbiome establishment and immune maturation. Early-life exposures are increasingly being recognised to play an important role in IBD risk. The composition of functions of the gut microbiome in the prenatal, perinatal, and postnatal period may be crucial towards development of health or disease, including IBD, later in life. We herein present a comprehensive summary of the interplay between early-life factors and microbiome perturbations, and their association with risk of IBD...
December 12, 2023: Gut
#25
JOURNAL ARTICLE
Boris Bačić, Zlatko Hrgović, Anis Cerovac, Ognjen Barčot, Jelena Sabljić, Stipe Dumančić, Blagoja Markoski, Mateo Leskur
The aim of this case report is to show the advantages of the extraperitoneal cesarean section (ECS) approach in a pregnant patient with multiple previous abdominal transperitoneal colon surgeries and Crohn's disease. A pregnant nulliparous woman with Crohn's disease was admitted for delivery. After delivery, a large rupture and lesion of the rectum was observed. Suturing of the vagina, rectum and sphincter was performed by an abdominal surgeon. Because of a very large and irregularly shaped rectum rupture, the patient underwent infraumbilical medial laparotomy and sigmoidostomy...
December 6, 2023: Zeitschrift Für Geburtshilfe und Neonatologie
#26
JOURNAL ARTICLE
Peng Guo, Wulan Cao
RATIONALE: Crohn disease (CD) and pregnancy often impact each other, which poses challenges for women with CD to successfully give birth to a healthy baby. The latest guideline recommends that patients with active inflammatory bowel disease delay pregnancy to induce remission and optimize disease control. Research data has showed that the incidence of infection and severe infection in patients treated with ustekinumab (UST) did not increase compared to those treated with a placebo. PATIENT CONCERNS: This report describes the entire process of a pregnant woman with CD who has undergone ileostomy and long-term enteral nutrition and requires biological agents to control the disease, from conception to delivery...
December 1, 2023: Medicine (Baltimore)
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JOURNAL ARTICLE
Linmin Hu, Siqing Wu, Yuelong Shu, Kai Su, Chunliang Wang, Danni Wang, Qiangsheng He, Xinyu Chen, Wenjing Li, Ningning Mi, Peng Xie, Jinyu Zhao, Shiyong Zhang, Jinqiu Yuan, Jianbang Xiang, Bin Xia
BACKGROUND AND AIMS: The long-term impact of maternal smoking during pregnancy (MSDP) on adult offspring's risk of Crohn's disease (CD) and ulcerative colitis (UC) remains uncertain. Our study aims to investigate the individual and combined effects of early life exposure (MSDP), offspring personal behavior (smoking), and genetic risk on the development of CD and UC in adult offspring. METHODS: We conducted a prospective cohort study using UK Biobank data, including 334,083 participants recruited between 2006-2010, with follow-up until December 31, 2021...
December 1, 2023: Journal of Crohn's & Colitis
#28
JOURNAL ARTICLE
Fiona Yeaman, Amelie Stritzke, Verena Kuret, Nastaran Sharifi, Cynthia H Seow, Amy Metcalfe, Yvette Leung
BACKGROUND: Thiopurines are commonly used to treat inflammatory bowel disease (IBD). Thiopurines are considered safe throughout pregnancy. However, a published study suggested the risk of neonatal anemia was increased if exposed to thiopurines in utero. This prospective cohort study aimed to determine if there is an increased risk of cytopenia among infants born to pregnant people with IBD, exposed or unexposed to thiopurines, compared to infants born to those without IBD. METHODS: Pregnant IBD patients, with and without thiopurine exposure, and one cohort of control individuals were recruited over a 5-year period...
October 2023: Crohn's & colitis 360
#29
Ayumi Ito, Maria Yonezawa, Shun Murasugi, Teppei Omori, Shinichi Nakamura, Katsutoshi Tokushige
The patient was a woman in her 40s who was diagnosed with Crohn's disease (CD) of the large and small intestines in 1996. In 2005, she was referred to our hospital for treatment. We treated her for 17 years with corticosteroids, biologics, immunosuppressive agents, 5-aminosalicylic acid, and nutrition care. However, her Crohn's Disease Activity Index remained between 200 and 250, indicating refractory CD. During her medical treatment, the patient also underwent 3 operations. One year ago, the patient became pregnant through in vitro fertilization...
2023: Case Reports in Gastroenterology
#30
JOURNAL ARTICLE
Annie Guo, Malin Östensson, Ketil Størdal, Johnny Ludvigsson, Karl Mårild
BACKGROUND: We aimed to investigate whether early-life hygiene-related factors influenced the risk of inflammatory bowel disease (IBD) in a Scandinavian population and test the association's consistency across cohorts. METHODS: This study followed 117 493 participants in the All Babies in Southeast Sweden study and the Norwegian Mother, Father, and Child Cohort Study. IBD diagnoses were defined by national registers. Comprehensive data on hygiene-related exposures, such as having pets, rural living, daycare attendance, and siblings, were retrieved from questionnaires administered from pregnancy until child's age of 36 months...
October 31, 2023: Inflammatory Bowel Diseases
#31
JOURNAL ARTICLE
Deniz Oluklu, Derya Uyan Hendem, Dilek Menekse Beser, Muradiye Yildirim, Bergen Laleli Koc, Ozgur Kara, Atakan Tanacan, Dilek Sahin
BACKGROUND: The altered maternal inflammatory milieu and changes in maternal vascular structure (arterial stiffness) and function may affect the fetal heart in pregnant women diagnosed with inflammatory bowel disease (IBD). AIMS: To investigate fetal cardiac functions in IBD pregnancies and to reveal the relationship between IBD duration and fetal cardiac functions. STUDY DESIGN: Prospective case-control study. SUBJECTS: The case group included 19 pregnant women with ulcerative colitis and seven with Crohn's disease who were in remission at the time of the study...
October 18, 2023: Early Human Development
#32
JOURNAL ARTICLE
Preeti Prakash, Anoushka Dua, Yair Blumenfeld, Po-Hung Chen, Alyssa M Parian, Berkeley N Limketkai
BACKGROUND: Many women with inflammatory bowel disease (IBD) are diagnosed by their reproductive years. Prior literature suggests that women with IBD may be at increased risk of adverse pregnancy outcomes. Biologics have revolutionized IBD treatment, and current evidence favors continuation during pregnancy. We sought to examine trends in pregnancy outcomes over 20 years with the evolution of IBD treatment. METHODS: Using the National Inpatient Sample, IBD and non-IBD obstetric hospitalizations were identified between 1998 and 2018 using International Classification of Diseases 9 and 10 codes...
October 19, 2023: Inflammatory Bowel Diseases
#33
REVIEW
Antonio M Caballero-Mateos, Miguel Quesada-Caballero, Guillermo A Cañadas-De la Fuente, Alberto Caballero-Vázquez, Francisco Contreras-Chova
Inflammatory Bowel Disease (IBD) presents distinct challenges during pregnancy due to its influence on maternal health and pregnancy outcomes. This literature review aims to dissect the existing scientific evidence on pregnancy in women with IBD and provide evidence-based recommendations for clinical management. A comprehensive search was conducted across scientific databases, selecting clinical studies, systematic reviews, and other pertinent resources. Numerous studies have underscored an increased risk of complications during pregnancy for women with IBD, including preterm birth, low birth weight, neonates small for gestational age, and congenital malformations...
September 25, 2023: Journal of Clinical Medicine
#34
JOURNAL ARTICLE
Jantien W Wieringa, Matthijs D Kruizinga, Gertjan J A Driessen, C Janneke van der Woude, Mette Julsgaard
BACKGROUND AND AIMS: ECCO guideline recommend postponing live attenuated vaccines in infants exposed to anti-Tumor Necrosis Factor alpha (anti-TNFα) in utero until drug clearance. The aim was to validate the predictive performance of the anti-TNFα clearance model. METHODS: Newborns and anti-TNFα concentrations from the prospective PETIT cohort were included. The anti-TNFα clearance model was used to predict all measured concentrations in the PETIT cohort, based on the measured cord blood concentration and the mean population clearance described in the model...
October 12, 2023: Journal of Crohn's & Colitis
#35
JOURNAL ARTICLE
Rishika Chugh, Millie D Long, Yue Jiang, Kimberly N Weaver, Dawn B Beaulieu, Ellen J Scherl, Uma Mahadevan
BACKGROUND: Pregnancy outcomes in inflammatory bowel disease (IBD) patients with quiescent disease are similar to the general population. Data from the Pregnancy Inflammatory bowel disease And Neonatal Outcomes (PIANO) registry have demonstrated the safety of anti-tumor necrosis factor alpha (TNFs) agents and thiopurines in pregnancy. The objective of this study was to provide information from the PIANO registry on maternal and fetal outcomes in patients exposed to the newer biologics ustekinumab (UST) and vedolizumab (VDZ)...
October 5, 2023: American Journal of Gastroenterology
#36
REVIEW
Gustavo G Nascimento, Preethi Balan, Silas Alves-Costa, Fernando Valentim Bitencourt, Ashish C Kalhan, Fabio R M Leite
OBJECTIVES: This study aimed to identify studies exploring oral and systemic conditions using Singapore data. METHODS: Studies were searched using the databases PubMed, Embase and Web of Science, with no publication date or language restrictions. Studies analysing Singaporean data were included in this review. RESULTS: Six domains were identified: pregnancy and gingivitis; tooth eruption, dental caries and early-life factors; Crohn's disease and oral microbiome; diabetes and periodontal diseases; number of teeth, chewing ability and cognitive status; and oral health and pneumonia...
October 1, 2023: Community Dentistry and Oral Epidemiology
#37
REVIEW
Daniela Pugliese, Giuseppe Privitera, Javier P Gisbert, María Chaparro
The management of inflammatory bowel disease requires continuous medical therapy to achieve and maintain disease control. Thus, women can be exposed to different drugs during conception, pregnancy, and lactation with potentially harmful effects on the mother, foetus, or nursing infant. Conventional drugs and anti-tumour necrosis factor (TNF)-α are considered safe and can be maintained throughout all these phases. Emergent, although limited, data support safety of vedolizumab and ustekinumab, with pregnancy, as well as maternal and neonatal outcomes comparable to women unexposed or treated with anti TNF-α drugs...
September 15, 2023: Digestive and Liver Disease
#38
REVIEW
Laura E Targownik, Natasha Bollegala, Vivian H Huang, Joseph W Windsor, M Ellen Kuenzig, Eric I Benchimol, Gilaad G Kaplan, Sanjay K Murthy, Alain Bitton, Charles N Bernstein, Jennifer L Jones, Kate Lee, Juan-Nicolás Peña-Sánchez, Noelle Rohatinsky, Sara Ghandeharian, Tal Davis, Jake Weinstein, James H B Im, Nazanin Jannati, Rabia Khan, Priscilla Matthews, Tyrel Jones May, Sahar Tabatabavakili, Rohit Jogendran, Elias Hazan, Mira Browne, Saketh Meka, Sonya Vukovic, Manisha Jogendran, Malini Hu, Jessica Amankwah Osei, Grace Y Wang, Tasbeen Akhtar Sheekha, Ghaida Dahlwi, Quinn Goddard, Julia Gorospe, Cyanne Nisbett, Shira Gertsman, James Sousa, Taylor Morganstein, Taylor Stocks, Ann Weber, Cynthia H Seow
Sex (the physical and physiologic effects resulting from having specific combinations of sex chromosomes) and gender (sex-associated behaviours, expectations, identities, and roles) significantly affect the course of inflammatory bowel disease (IBD) and the experience of living with IBD. Sex-influenced physiologic states, like puberty, the menstrual cycle, pregnancy, and andropause/menopause may also impact and be impacted by IBD. While neither Crohn's disease nor ulcerative colitis is commonly considered sex-determined illnesses, the relative incidence of Crohn's disease and ulcerative colitis between males and females varies over the life cycle...
September 2023: Journal of the Canadian Association of Gastroenterology
#39
JOURNAL ARTICLE
Christian P Selinger, Robyn Laube, Helen Steed, Matthew Brookes, Nihr BioResource, Rupert W L Leong
BACKGROUND: Adherence to inflammatory bowel disease (IBD) medication is crucial to maintain remission, especially during pregnancy. OBJECTIVE: To examine the influence of family planning and pregnancy-related patient knowledge regarding IBD and pregnancy on adherence. DESIGN: Cross-sectional survey study. METHODS: We surveyed female patients with IBD aged 18-35 years, who at recruitment to the UK IBD BioResource had not had children...
2023: Therapeutic Advances in Gastroenterology
#40
REVIEW
Zikica Jovicic, Sanja Dragasevic, Ana Petkovic, Snezana Plesinac, Aleksandra Sokic Milutinovic, Maja Stojanovic
Takayasu arteritis (TA) is a large vessel vasculitis affecting predominantly females below the age of 40. Patients with TA seem to be at increased risk for adverse pregnancy outcomes, resulting in mother or child complications. Although few studies analyzed the presence of antiphospholipid antibodies (APLA) in TA patients, an association between antiphospholipid syndrome (APS) and TA is rarely reported in the literature, mainly in the form of case reports. In fact, very few data regarding pregnancy outcomes in patients with TA and APS are available...
September 1, 2023: Rheumatology International
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