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https://www.readbyqxmd.com/read/28185689/imaging-of-acute-pelvic-pain-in-girls-ovarian-torsion-and-beyond-%C3%A2
#1
REVIEW
Lena Naffaa, Tejaswini Deshmukh, Shanthan Tumu, Chris Johnson, Kevin P Boyd, Arthur B Meyers
: Identifying the etiology of acute pelvic pain in girls is often clinically challenging. Particularly in young girls, it is often difficult to determine if acute pelvic symptoms are originating from a gynecologic source or from a genitourinary or gastrointestinal etiology based on the child's clinical examination alone. Therefore, imaging plays a key role in establishing a diagnosis and in directing medical and surgical treatment. Pediatric gynecologic conditions, which can present acutely with pain or mass or both include ovarian torsion, hematometrocolpos, pelvic inflammatory disease, inguinal hernias containing an ovary or the uterus or both, adnexal cysts, pregnancy, vaginal foreign bodies, and ovarian vein thrombosis...
December 21, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28169436/vedolizumab-exposure-in-pregnancy-outcomes-from-clinical-studies-in-inflammatory-bowel-disease
#2
U Mahadevan, S Vermeire, K Lasch, B Abhyankar, F Bhayat, A Blake, M Dubinsky
BACKGROUND: Vedolizumab is a gut-selective immunoglobulin G1 monoclonal antibody to α4 β7 integrin for the treatment of Crohn's disease (CD) and ulcerative colitis (UC). Prospective clinical studies of vedolizumab in pregnancy have not been conducted; therefore, existing safety data of vedolizumab in pregnancy were examined. AIM: To assess pregnancy outcomes in females and partners of males who received vedolizumab. METHODS: All pregnancy data collected during the clinical programme (from 14 May 2007 to 27 June 2013) and in the post-marketing setting (to 19 November 2015) were analysed...
February 7, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28160250/thiopurines-and-methotrexate-use-in-ibd-patients-in-a-biologic-era
#3
REVIEW
Gerassimos J Mantzaris
Although we have been living in the era of biologic therapy for several decades, the use of immunomodulators (primarily thiopurines [azathioprine and mercaptopurine] and less so methotrexate) still remains an important component of the inflammatory bowel disease (IBD) pharmaceutical arsenal. Thiopurines as monotherapy exert corticosteroid-sparing effects and can maintain long-term remission in a considerable proportion of patients who have frequent relapses and are or have become mesalazine and/or corticosteroid intolerant or refractory...
February 3, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28158501/third-european-evidence-based-consensus-on-diagnosis-and-management-of-ulcerative-colitis-part-1-definitions-diagnosis-extra-intestinal-manifestations-pregnancy-cancer-surveillance-surgery-and-ileo-anal-pouch-disorders
#4
Fernando Magro, Paolo Gionchetti, Rami Eliakim, Sandro Ardizzone, Alessandro Armuzzi, Manuel Barreiro-de Acosta, Johan Burisch, Krisztina B Gecse, Ailsa L Hart, Pieter Hindryckx, Cord Langner, Jimmy K Limdi, Gianluca Pellino, Edyta Zagórowicz, Tim Raine, Marcus Harbord, Florian Rieder
No abstract text is available yet for this article.
February 2, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28004853/ustekinumab-therapy-for-crohn-s-disease-during-pregnancy-a-case-report-and-review-of-the-literature
#5
X Cortes, J Borrás-Blasco, B Antequera, S Fernandez-Martinez, E Casterá, S Martin, J R Molés
WHAT IS KNOWN AND OBJECTIVES: The safety of continued ustekinumab (UST) therapy during pregnancy remains unclear in patients with Crohn's disease (CD). There are no meta-analysis reports of exposure to UST during pregnancy. The objective was to describe a case of a pregnant patient with CD who was successfully treated with UST maintenance therapy throughout the pregnancy and delivered a baby boy without any congenital malformations, neurological abnormalities or birth defects. CASE SUMMARY: A 37-year-old patient with CD treated with UST became pregnant...
December 22, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27997432/the-efficacy-of-assisted-reproduction-in-women-with-inflammatory-bowel-disease-and-the-impact-of-surgery-a-nationwide-cohort-study
#6
Sonia Friedman, Pia Veldt Larsen, Jens Fedder, Bente Mertz Nørgård
BACKGROUND: In this study, we analyze the chance of a live birth and the impact of inflammatory bowel disease surgery in women with Crohn's disease (CD) or ulcerative colitis (UC) who have undergone assisted reproductive technology (ART) treatments. METHODS: This is a nationwide cohort study based on the Danish health registries. We compare all women with and without CD or UC who received a first time ART treatment from January 1, 1994 to June 30, 2012 with follow-up until December 31, 2013...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27822107/the-danish-national-registry-for-biological-therapy-in-inflammatory-bowel-disease
#7
REVIEW
Lone Larsen, Michael Dam Jensen, Michael Due Larsen, Rasmus Gaardskær Nielsen, Niels Thorsgaard, Ida Vind, Signe Wildt, Jens Kjeldsen
AIM: The aims of The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease are to ensure that biological therapy and the clinical management of patients with inflammatory bowel disease (IBD) receiving biological treatment are in accordance with the national clinical guidelines and, second, the database allows register-based clinical epidemiological research. STUDY POPULATION: The study population comprises all Danish patients with IBD (both children and adults) with ulcerative colitis, Crohn's disease, and IBD unclassified who receive biological therapy...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27785711/long-term-disease-course-and-pregnancy-outcomes-in-women-with-inflammatory-bowel-disease-an-indian-cohort-study
#8
Rajesh Kumar Padhan, Saurabh Kedia, Sushil Kumar Garg, Sawan Bopanna, V Pratap Mouli, Rajan Dhingra, Govind Makharia, Vineet Ahuja
BACKGROUND: The literature on interaction between pregnancy and inflammatory bowel disease (IBD) is inconsistent, and there are no reports on this aspect from Asia. This study evaluated the impact both IBD and pregnancy have on each other in a large cohort of Indian patients. METHODS: In total, 514 females with ulcerative colitis (UC) or Crohn's disease (CD) aged between 18 and 45 years attending IBD clinic, at our institute, from July 2004 to July 2013 were screened, and patients with data on pregnancy status were included (n = 406)...
October 26, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27760078/experts-opinion-on-the-practical-use-of-azathioprine-and-6-mercaptopurine-in-inflammatory-bowel-disease
#9
Christian Mottet, Alain M Schoepfer, Pascal Juillerat, Jacques Cosnes, Florian Froehlich, Vera Kessler-Brondolo, Frank Seibold, Gerhard Rogler, Stephan R Vavricka, Pierre Michetti
The relevance of azathioprine and 6-mercaptopurine therapy in inflammatory bowel disease, Crohn's disease, and ulcerative colitis, has been challenged in recent publications. In this article, a panel of experts gives advice, based on the relevant literature, on indications and practical use of azathioprine/6-mercaptopurine, prevention, and management of drug adverse reactions and special situations such as vaccination, pregnancy, and lactation.
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27739352/preterm-birth-in-women-with-inflammatory-bowel-disease-the-association-with-disease-activity-and-drug-treatment
#10
Gabriella Bröms, Fredrik Granath, Olof Stephansson, Helle Kieler
BACKGROUND: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC) have been associated with an increased risk of preterm birth. MATERIAL AND METHODS: We identified all 246 singleton preterm births among women with IBD between July 2006 and December 2010 as cases and an equal number of controls with IBD from the Swedish national health registers, matched by maternal age, parity and IBD diagnosis (CD/UC). From register data and medical charts, we obtained information on reproductive history, comorbidity, disease activity and drug treatment (corticosteroids, 5-aminosalicylates, sulfasalazine, thiopurines and anti-TNF) as risk factors for preterm birth...
December 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27688664/pregnancy-and-inflammatory-bowel-disease-do-we-provide-enough-patient-education-a-british-study-of-1324-women
#11
Isabel Carbery, Jihane Ghorayeb, Anna Madill, Christian P Selinger
AIM: To examine patient knowledge and factors influencing knowledge about pregnancy in British women with inflammatory bowel disease (IBD). METHODS: This is a post hoc analysis of a study of female members of Crohn's and Colitis United Kingdom, aged 18-45 years who were sent an online questionnaire recording patient demographics, education, employment, marital status, and disease characteristics. Disease related pregnancy knowledge was recorded using Crohn's and colitis pregnancy knowledge score (CCPKnow)...
September 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27651962/listeria-rhombencephalitis-complicating-anti-tnf-treatment-during-an-acute-flare-of-crohn-s-colitis
#12
L Stratton, G R Caddy
Patients with Crohn's disease often require the use of immunosuppressant drugs to control disease activity. Such medication includes steroids, azathioprine, and biologic therapy. These suppress the immune response, and the patient is more susceptible to infection. We present a case of a 69-year-old gentleman with a history of Crohn's colitis who had ongoing symptoms of diarrhoea in spite of standard treatment. Biologic therapy was considered to be the next step, and screening for infection was undertaken prior to use...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27639376/prevalence-of-osteoporosis-in-the-italian-population-and-main-risk-factors-results-of-bonetour-campaign
#13
Loredana Cavalli, Andrea Guazzini, Luisella Cianferotti, Simone Parri, Tiziana Cavalli, Alessia Metozzi, Francesca Giusti, Caterina Fossi, Dennis M Black, Maria Luisa Brandi
BACKGROUND: BoneTour is a campaign conducted throughout the Italian territory for the assessment of Italian people bone status and for the prevention of osteoporosis. METHODS: A total of 7305 sequential subjects of both sexes were screened, collecting clinical data through the FRAX™ questionnaire, and measuring heel bone stiffness by Quantitative Ultrasonography (QUS). The 10-year risk for hip and major osteoporotic fractures was calculated taking into account personal or family history of fragility fracture, smoking, alcohol abuse, rheumatoid arthritis, prolonged steroids assumption...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27602237/infertility-in-men-with-inflammatory-bowel-disease
#14
REVIEW
Takeshi Shin, Hiroshi Okada
Inflammatory bowel disease (IBD) predominantly affects young adults. Fertility-related issues are therefore important in the management of patients with IBD. However, relatively modest attention has been paid to reproductive issues faced by men with IBD. To investigate the effects of IBD and its treatment on male fertility, we reviewed the current literature using a systematic search for published studies. A PubMed search were performed using the main search terms "IBD AND male infertility", "Crohn's disease AND male infertility", "ulcerative colitis AND male infertility"...
August 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27552976/evaluation-of-pregnancy-outcomes-from-the-tysabri%C3%A2-natalizumab-pregnancy-exposure-registry-a-global-observational-follow-up-study
#15
Susan Friend, Sandra Richman, Gary Bloomgren, Lynda M Cristiano, Madé Wenten
BACKGROUND: Patients with multiple sclerosis (MS) or Crohn's disease (CD) being treated with natalizumab (Tysabri®, Biogen) who are planning to become pregnant or discover they are pregnant after exposure to natalizumab are currently advised to balance the potential benefits and potential risks of exposure when considering treatment options. This study was undertaken to evaluate pregnancy outcomes of women with MS or CD who were exposed to natalizumab at any time within 3 months prior to conception or during pregnancy...
August 24, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27548630/proper-use-of-inflammatory-bowel-disease-drugs-during-pregnancy
#16
S L Kanis, C J van der Woude
Crohn's disease and ulcerative colitis, referred to as inflammatory bowel disease (IBD), are chronic, relapsing conditions. Patients are often diagnosed at a reproductive age, and therefore questions about fertility and reproductions often arise. Preconceptional counseling is the most important aspect in the management of IBD patients with a pregnancy wish. Patients should be counseled on the influence of IBD and IBD drugs on pregnancy. Most drugs are not related to adverse outcome while used during pregnancy...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27537054/inflammatory-bowel-disease-influence-and-implications-in-reproduction
#17
Louise E Glover, Blair Fennimore, Mary Wingfield
The incidence and prevalence of inflammatory bowel disease (IBD) continues to rise with time, signifying its emergence as a global disease. Clinical onset of IBD, comprising Crohn's disease and ulcerative colitis, typically occurs before or at peak reproductive age. Although active disease in female patients is associated with reduced fertility and adverse obstetric outcomes in pregnancy, the molecular mechanisms underlying this altered reproductive course, and its impact on IBD transmission to offspring, remain poorly understood...
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27399984/adherence-to-medical-treatment-in-relation-to-pregnancy-birth-outcome-breastfeeding-behavior-among-women-with-crohn-s-disease
#18
MULTICENTER STUDY
Mette Julsgaard
BACKGROUND: Crohn's disease (CD) is common among women of fertile age, and it often requires maintenance medical treatment. Adherence to medical treatment among women with CD prior to, during, and after pregnancy has, however, never been examined. Although CD women have increased risk of adverse pregnancy outcomes, little is known about predictors for these outcomes in women with CD. In addition, the impact of breastfeeding on disease activity remains controversial. AIMS: The aims of this PhD thesis were to determine adherence to treatment and to investigate predictors for and prevalence rates of non-adherence to maintenance medical treatment among women with CD prior to, during, and after pregnancy; to assess pregnancy outcomes among women with CD, taking medical treatment, smoking status, and disease activity into account; to assess breastfeeding rates and the impact of breastfeeding on the risk of relapse...
July 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27349339/the-effects-of-active-ibd-during-pregnancy-in-the-era-of-novel-ibd-therapies
#19
Alison de Lima-Karagiannis, Zuzana Zelinkova-Detkova, Christien Janneke van der Woude
OBJECTIVES: Previous data on inflammatory bowel disease (IBD) relapse during pregnancy mainly originate from retrospective studies. The aim of this study was therefore (i) to evaluate the effect of active disease at conception and IBD disease type on disease relapse during pregnancy and (ii) to study the effects of disease relapse during pregnancy on birth outcomes in a prospective cohort with adequate representation of current treatments. METHODS: From 2008 to 2014, IBD women were recruited from an ongoing prospective clinical cohort...
September 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27322103/assessment-of-disease-related-knowledge-and-possible-factors-associated-with-the-knowledge-level-among-chilean-patients-with-inflammatory-bowel-disease
#20
Daniela Simian, Lilian Flores, Rodrigo Quera, Udo Kronberg, Patricio Ibáñez, Carolina Figueroa, Jaime Lubascher
AIMS AND OBJECTIVES: To assess disease-related knowledge among patients with IBD and to identify the factors that are possibly associated with the knowledge level. BACKGROUND: Disease-related knowledge can positively influence the acceptance of the disease, increase treatment compliance and improve the quality of life in patients with IBD. DESIGN: An observational, cross-sectional study was conducted and prospectively included patients from the IBD program between October 2014 and July 2015...
June 20, 2016: Journal of Clinical Nursing
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