keyword
https://read.qxmd.com/read/38435974/development-and-validation-of-a-risk-score-model-for-predicting-autism-based-on-pre-and-perinatal-factors
#21
JOURNAL ARTICLE
Jianjun Ou, Huixi Dong, Si Dai, Yanting Hou, Ying Wang, Xiaozi Lu, Guanglei Xun, Kun Xia, Jingping Zhao, Yidong Shen
BACKGROUND: The use of pre- and perinatal risk factors as predictive factors may lower the age limit for reliable autism prediction. The objective of this study was to develop a clinical model based on these risk factors to predict autism. METHODS: A stepwise logistic regression analysis was conducted to explore the relationships between 28 candidate risk factors and autism risk among 615 Han Chinese children with autism and 615 unrelated typically developing children...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38420105/a-rare-case-of-autoimmune-disorder-as-a-trigger-for-atypical-hemolytic-uremic-syndrome
#22
Amit Pasari, Manish Balwani, Prasad Gurjar, Kapil Sejpal, Charulata Bawankule, Priyanka Tolani, Shubham Dubey, Pranjal Kashiv, Amol Bhawane, Sunny Malde, Sushrut Gupta
Autoimmune diseases may act as a trigger for atypical hemolytic uremic syndrome (aHUS). Triggers for aHUS may include autoimmune diseases, infections, metabolic conditions, pregnancy, and transplants. aHUS-mediated injury to various organs, especially kidneys, can be life-threatening. Here, we present the case of a young female who had perinuclear antineutrophil cytoplasmic antibody (p-ANCA)-associated vasculitis and was diagnosed with aHUS. We consider underlying autoimmune p-ANCA-associated vasculitis as a trigger for aHUS in this case...
January 2024: Curēus
https://read.qxmd.com/read/38417259/relationship-between-maternal-obesity-and-first-trimester-tsh-in-women-with-negative-anti-tpo-antibodies
#23
JOURNAL ARTICLE
Laura Croce, Fausta Beneventi, Federica Ripepi, Irene De Maggio, Alberto Malovini, Camilla Bellingeri, Francesca Coperchini, Marsida Teliti, Mario Rotondi, Arsenio Spinillo, Flavia Magri
OBJECTIVE: obesity is associated with increased Thyroid-stimulating-hormone (TSH) in non-pregnant subjects, but this phenomenon has not been fully characterized during pregnancy. Our aim was to evaluate the impact of Body-Mass-Index (BMI) on first-trimester TSH in a wide cohort of pregnant women with negative anti-Thyreoperoxidase-Antibodies (AbTPO) and its implications on uterine-artery pulsatility-index (UtA-PI), a marker of early placentation. METHODS: the study included 2268 AbTPO-negative pregnant women at their first antenatal visit...
February 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38408809/the-changes-in-adrenal-developmental-programming-and-homeostasis-in-offspring-induced-by-glucocorticoids-exposure-during-pregnancy
#24
REVIEW
Yawen Chen, Hui Wang
Clinically, synthetic glucocorticoids are often used to treat maternal and fetal related diseases, such as preterm birth and autoimmune diseases. Although its clinical efficacy is positive, it will expose the fetus to exogenous glucocorticoids. Adverse environments during pregnancy (e.g., exogenous glucocorticoids exposure, malnutrition, infection, hypoxia, and stress) can lead to fetal overexposure to endogenous maternal glucocorticoids. Basal glucocorticoids levels in utero are crucial in determining fetal tissue maturation and its postnatal fate...
2024: Vitamins and Hormones
https://read.qxmd.com/read/38405993/a-genome-wide-association-study-suggests-new-susceptibility-loci-for-primary-antiphospholipid-syndrome
#25
Desiré Casares-Marfil, Manuel Martínez-Bueno, Maria Orietta Borghi, Guillermo Pons-Estel, Guillermo Reales, Yu Zuo, Gerard Espinosa, Timothy Radstake, Lucas L van den Hoogen, Chris Wallace, Joel Guthridge, Judith A James, Ricard Cervera, Pier Luigi Meroni, Javier Martin, Jason S Knight, Marta E Alarcón-Riquelme, Amr H Sawalha
OBJECTIVES: Primary antiphospholipid syndrome (PAPS) is a rare autoimmune disease characterized by the presence of antiphospholipid antibodies and the occurrence of thrombotic events and pregnancy complications. Our study aimed to identify novel genetic susceptibility loci associated with PAPS. METHODS: We performed a genome-wide association study comprising 5,485 individuals (482 affected individuals) of European ancestry. Significant and suggestive independent variants from a meta-analysis of approximately 7 million variants were evaluated for functional and biological process enrichment...
December 5, 2023: medRxiv
https://read.qxmd.com/read/38398450/transient-neonatal-myasthenia-gravis-as-a-common-complication-of-a-rare-disease-a-systematic-review
#26
REVIEW
Jenny Linnea Victoria Lindroos, Marte-Helene Bjørk, Nils Erik Gilhus
Myasthenia gravis (MG) is a rare autoimmune disease. Transient neonatal myasthenia gravis (TNMG) is caused by pathogenic maternal autoantibodies that cross the placenta and disrupt signaling at the neuromuscular junction. This is a systematic review of this transient immunoglobulin G (IgG)-mediated disease. TNMG affects 10-20% of children born to mothers with MG. The severity of symptoms ranges from minor feeding difficulties to life-threatening respiratory weakness. Minor symptoms might go unnoticed but can still interfere with breastfeeding...
February 17, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38396391/hellp-syndrome-and-differential-diagnosis-with-other-thrombotic-microangiopathies-in-pregnancy
#27
REVIEW
Stefano Raffaele Giannubilo, Daniela Marzioni, Giovanni Tossetta, Andrea Ciavattini
Thrombotic microangiopathies (TMAs) comprise a distinct group of diseases with different manifestations that can occur in both pediatric and adult patients. They can be hereditary or acquired, with subtle onset or a rapidly progressive course, and they are particularly known for their morbidity and mortality. Pregnancy is a high-risk time for the development of several types of thrombotic microangiopathies. The three major syndromes are hemolysis, elevated liver function tests, and low platelets (HELLP); hemolytic uremic syndrome (HUS); and thrombotic thrombocytopenic purpura (TTP)...
February 6, 2024: Diagnostics
https://read.qxmd.com/read/38395801/causal-effects-of-endometriosis-on-sle-ra-and-ss-risk-evidence-from-meta-analysis-and-mendelian-randomization
#28
JOURNAL ARTICLE
Tianyou Tang, Yi Zhong, Sipei Xu, Huilin Yu
BACKGROUND: Endometriosis is an underdiagnosed disorder that affects an estimated 6-10% of women of reproductive age. Endometriosis has been reported in epidemiological studies to be associated with autoimmune diseases. However, the relationship remains controversial. METHODS: A meta-analysis of observational studies was undertaken to evaluate the risk of autoimmune diseases in patients with endometriosis. The relevant studies were retrieved via the databases Medline, Embase and Web of Science until July 20, 2023...
February 23, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38395066/innovative-therapies-for-acquired-hemophilia-a
#29
JOURNAL ARTICLE
Massimo Franchini, Daniele Focosi
Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder which can be life-threatening. AHA is due to autoantibodies against coagulation factor VIII. Disease onset may be idiopathic (approximately half of the cases) or triggered by autoimmune disorders, cancers, drugs, infections, or pregnancy. Besides treating the underlying disorder, specific AHA treatments include management of bleeding and inhibitor eradication. Various first-line and second-line hemostatic and immunosuppressive agents are currently available for the management of AHA...
February 23, 2024: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/38394717/umbilical-artery-thrombosis-a-case-report-of-prenatal-diagnosis-and-systematic-review-of-the-literature
#30
REVIEW
Eleonora Romani, Laura Marinelli, Ilaria Ponziani, Giulia Masini, Francesca Castiglione, Eleonora Nardi, Lucia Pasquini
Umbilical Artery Thrombosis (UAT) is an extremely rare complication of pregnancy strongly associated with severe fetal distress and death. The pathogenesis is still unclear but it is often associated with anatomical cord abnormalities that leads to blood stasis and thrombosis formation. Other possible risk factors are maternal thrombophilia, autoimmune disease, gestational diabetes, hypertension disorders of pregnancy and Rh-alloimmunization. The most common clinical symptom is the reduction of fetal movements...
February 10, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38389171/effects-of-autoimmune-abnormalities-on-fertility-and-placental-morphology-in-mice
#31
JOURNAL ARTICLE
Risa Yamanaka, Osamu Ichii, Teppei Nakamura, Yuki Otani, Takashi Namaba, Yasuhiro Kon
Autoimmune diseases (AIDs) alter the placental immune environment leading to fetal loss. This study investigated the effects of AIDs on pregnancy and the placenta in AID-prone MRL/MpJ- Faslpr/lpr mice and wild-type MRL/MpJ, which were mated with male MRL/MpJ and MRL/MpJ- Faslpr/lpr at five months and defined as moLpr and moMpJ, respectively. AID indices (spleen weight and serum autoantibody levels) and fertility status (number and size of fetuses, morphology, and comprehensive gene expression of placentas) were evaluated on gestational day 15...
December 2024: Autoimmunity
https://read.qxmd.com/read/38387195/maternal-and-fetal-outcomes-of-pregnancy-in-women-with-primary-systemic-vasculitis-a-single-center-cohort-study-of-20-patients-and-30-pregnancies
#32
JOURNAL ARTICLE
Sara Beça, Marco A Alba, José Hernández-Rodríguez, Georgina Espígol-Frigolé, Sergio Prieto-González, María C Cid, Núria Baños, Gerard Espinosa
OBJECTIVES: To analyze pregnancy outcomes of patients with primary systemic vasculitis followed in a third-level referral center. METHODS: Retrospective cohort study of all pregnant women with systemic vasculitis followed between 2009 and 2022 at the High-Risk Pregnancy Clinic of the Department of Systemic Autoimmune Diseases of the Hospital Clínic, Barcelona. RESULTS: Twenty women with primary vasculitis were identified, with a total of 30 pregnancies...
February 14, 2024: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/38380895/newborns-with-congenital-complete-heart-block-advice-for-perinatal-care-providers
#33
JOURNAL ARTICLE
Vijay Rani, Renu Sharma, Jagjit Singh Dalal, Anita Saxena, Shamsher Singh Lohchab, Monika Dalal
Congenital complete heart block (CCHB) is a rare, but a potentially life-threatening manifestation of autoimmune diseases in neonates. Bradycardia in CCHB can be misdiagnosed as foetal distress in utero and thus precipitating a Caesarean section. We report a case series of three neonates with bradycardia without any electrolyte abnormalities and structurally normal hearts with favourable outcomes.
February 21, 2024: Tropical Doctor
https://read.qxmd.com/read/38380176/update-on-sex-specific-risk-factors-in-cardiovascular-disease
#34
REVIEW
Andrew H Nguyen, Madelyn Hurwitz, Scott A Sullivan, Antonio Saad, Jamie L W Kennedy, Garima Sharma
Cardiovascular disease (CVD) is the leading cause of death worldwide and accounts for roughly 1 in 5 deaths in the United States. Women in particular face significant disparities in their cardiovascular care when compared to men, both in the diagnosis and treatment of CVD. Sex differences exist in the prevalence and effect of cardiovascular risk factors. For example, women with history of traditional cardiovascular risk factors including hypertension, tobacco use, and diabetes carry a higher risk of major cardiovascular events and mortality when compared to men...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38376734/reproductive-effect-by-rheumatoid-arthritis-and-related-autoantibodies
#35
REVIEW
Ping-Fen Li, Shan Li, Peng-Sheng Zheng
Rheumatoid arthritis (RA) is a common inflammatory arthritis in women. The effects of RA on the reproductive system are usually overlooked, as RA is not diagnosed until later in reproductive age. Whether RA itself or its related rheumatoid antibodies have an impact on female reproductive function has long been a thought-provoking issue. In brief, relevant epidemiological evidence has shown that women affected by RA are more likely to have coexisting reproductive disorders, including infertility, endometriosis, and premature ovarian insufficiency (POI), or to subsequently develop them...
February 20, 2024: Rheumatology and Therapy
https://read.qxmd.com/read/38373491/-indirects-causes-of-maternal-deaths-except-stroke-cardiovascular-diseases-and-infections-in-france-2016-2018
#36
JOURNAL ARTICLE
Véronique Le Guern, Mathias Rossignol, Jacques Lepercq
Maternal deaths from indirect obstetric causes result from a pre-existing condition or a condition that occurred during pregnancy without obstetric causes but was aggravated by the physiological effects of pregnancy. Twenty-nine deaths with an indirect cause related to a pre-existing condition, excluding circulatory diseases or infections, were analysed by the expert committee. Pre-pregnancy pathology was documented in 16 women (epilepsy, n=7; amyloid angiopathy, n=1; Dandy Walker syndrome, n=1; autoimmune diseases, n=3; diffuse infiltrative pneumonitis, n=1; thrombotic thrombocytopenic purpura, n=1; ovarian cancer in fragile X, n=1; major sickle cell disease, n=1)...
February 17, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38347605/dynamic-changes-in-the-gut-microbiota-during-three-consecutive-trimesters-of-pregnancy-and-their-correlation-with-abnormal-glucose-and-lipid-metabolism
#37
JOURNAL ARTICLE
Yiyang Gao, Jinjia Zhang, Haiying Chen, Xiaohui Jin, Zhenyu Lin, Chenling Fan, Zhongyan Shan, Weiping Teng, Jing Li
INTRODUCTION: During normal pregnancy, changes in the gut microbiota (GM) in response to physiological alterations in hormonal secretion, immune functions and homeostasis have received extensive attention. However, the dynamic changes in the GM during three consecutive trimesters of pregnancy and their relationship with glucose and lipid metabolism have not been reported. In this study, we aimed to investigate the dynamic changes in the diversity and species of the GM during three consecutive trimesters in women who naturally conceived, and their relationships with abnormal fasting blood glucose (FBG) and serum lipid levels...
February 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38338701/altered-levels-of-natural-autoantibodies-against-heat-shock-proteins-in-pregnant-women-with-hashimoto-s-thyroiditis
#38
JOURNAL ARTICLE
Diána Simon, Szabina Erdő-Bonyár, Katalin Böröcz, Noémi Balázs, Ahmed Badawy, Anna Bajnok, Jasper Nörenberg, Tímea Serény-Litvai, Ákos Várnagy, Kálmán Kovács, Eszter Hantosi, Emese Mezősi, Péter Németh, Tímea Berki
The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto's thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study's objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP)...
January 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38331588/single-cell-transcriptome-analyses-reveal-disturbed-decidual-homoeostasis-in-obstetric-antiphospholipid-syndrome
#39
JOURNAL ARTICLE
Chenyang Lu, Rui Gao, Pingying Qing, Xun Zeng, Xin Liao, Meng Cheng, Lang Qin, Yi Liu
OBJECTIVES: Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disease characterised by the presence of antiphospholipid antibodies in circulation and pathological pregnancy. However, the pathogenesis of OAPS remains unknown. We aimed to reveal cellular compositions and molecular features of decidual cells involved in the development of OAPS using single-cell RNA sequencing (scRNA-seq). METHODS: We performed unbiased scRNA-seq analysis on the first-trimester decidua from five OAPS patients and five healthy controls (HCs), followed by validations with flow cytometry, immunohistochemical staining and immunofluorescence in a larger cohort...
February 8, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38326790/unique-case-of-lymphocytic-hypophysitis-with-normal-pituitary-hormone-serology-mimicking-a-non-functioning-pituitary-adenoma
#40
JOURNAL ARTICLE
Kyle Shen, Catherine Cadang, Daniel Phillips, Varsha Babu
BACKGROUND: Lymphocytic hypophysitis is a rare autoimmune condition that usually presents during pregnancy and causes inflammation of the pituitary gland. Although the pathophysiology is not well understood, it often presents with headaches, visual disturbances, and symptoms of hypopituitarism. However, not all cases may present with hypopituitarism which can make this rare disease with an incidence of ~ 1 in 9 million much more difficult to diagnose. CASE PRESENTATION: We present a 35-year-old G4P4 woman with progressive vision loss and intermittent frontal headaches during her first trimester through 2 months postpartum...
February 8, 2024: BMC Endocrine Disorders
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