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https://www.readbyqxmd.com/read/29774063/dual-target-gene-therapy-to-eml4-alk-nsclc-by-a-gold-nanoshell-based-system
#1
Siwen Li, Yuxi Liu, Yalan Rui, Liping Tang, Samuel Achilefu, Yueqing Gu
Although EML4-ALK transforming fusion gene is represented in only 8% of non-small cell lung cancer (NSCLC) cases, its expression is partly responsive for the failure of current NSCLC treatments. Preventing secondary mutation of the ALK protein through direct gene manipulation could overcome NSCLC drug resistance. Method: In this study, we developed a gold nanoshell (HAuNs) drug carrier for delivery and selective photo-thermal release of genes that target ALK and microRNA-301 in NSCLC. Additionally, the densely-coated nanoshell adsorbed high amounts of the positively-charged anticancer drug doxorubicin (DOX), generating an exciting multidimensional treatment strategy that includes gene-, thermal- and chemo- therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29773967/stochastic-contagion-models-without-immunity-their-long-term-behaviour-and-the-optimal-level-of-treatment
#2
Raimund M Kovacevic
In this paper we analyze two stochastic versions of one of the simplest classes of contagion models, namely so-called SIS models. Several formulations of such models, based on stochastic differential equations, have been recently discussed in literature, mainly with a focus on the existence and uniqueness of stationary distributions. With applicability in view, the present paper uses the Fokker-Planck equations related to SIS stochastic differential equations, not only in order to derive basic facts, but also to derive explicit expressions for stationary densities and further characteristics related to the asymptotic behaviour...
2018: Central European Journal of Operations Research
https://www.readbyqxmd.com/read/29773123/circumstances-of-child-deaths-in-mali-and-uganda-a-community-based-confidential-enquiry
#3
Merlin L Willcox, Elias Kumbakumba, Drissa Diallo, Vincent Mubangizi, Peter Kirabira, Florence Nakaggwa, Birungi Mutahunga, Chiaka Diakité, Eugene Dembélé, Mamadou Traoré, Pierre Daou, Drissa Bamba, Amadou Traoré, Diafara Berthé, Nick Wooding, Kieran Dinwoodie, Sarah Capewell, Hamish Foster, Rowena Neville, Joseph Ngonzi, Jerome Kabakyenga, David Mant, Anthony Harnden
BACKGROUND: Interventions to reduce child deaths in Africa have often underachieved, causing the Millennium Development Goal targets to be missed. We assessed whether a community enquiry into the circumstances of death could improve intervention effectiveness by identifying local avoidable factors and explaining implementation failures. METHODS: Deaths of children younger than 5 years were ascertained by community informants in two districts in Mali (762 deaths) and three districts in Uganda (442 deaths) in 2011-15...
June 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29773055/crystal-engineering-upcoming-paradigm-for-efficacious-pulmonary-drug-delivery
#4
Preshita P Desai, Sanyat S Mapara, Vandana B Patravale
BACKGROUND AND OBJECTIVE: Pulmonary drug delivery has transformed over a past few decades from being a platform for local pulmonary disease treatment to systemic drug delivery opportunities. In case of pulmonary delivery systems, particle properties are critical as they affect inhalation efficacy, pulmonary deposition, drug delivery and overall performance. With this in view, particle engineering has emerged as an advanced science that helps in designing of efficacious pulmonary delivery systems...
May 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29772284/effect-of-excipient-properties-water-activity-and-water-content-on-the-disproportionation-of-a-pharmaceutical-salt
#5
Mitulkumar A Patel, Suman Luthra, Sheri L Shamblin, Kapildev K Arora, Joseph F Krzyzaniak, Lynne S Taylor
Excipients are crucial components of most pharmaceutical formulations. In the case of a solid oral dosage formulation containing the salt form of a weakly ionizable drug, excipient selection is critical, as some excipients are known to cause salt disproportionation (conversion of salt to the free form). Therefore, robust formulation design necessitates an in-depth understanding of the factors impacting salt disproportionation during processing or storage as this can negatively impact product quality and performance...
May 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29771113/crystal-chemical-substitution-at-ca-and-la-sites-in-cala-4-sio-4-3-o-to-design-the-composition-ca-1-x-m-x-la-4-x-re-x-sio-4-3-o-for-nuclear-waste-immobilization-and-its-influence-on-the-thermal-expansion-behavior
#6
Ramya Ravikumar, Buvaneswari Gopal, Hrudananda Jena
The oxysilicate apatite host CaLa4 (SiO4 )3 O has been explored for immobilization of radioactive nuclides. Divalent ion, trivalent rare earth ion, and combined ionic substitutions in the silicate oxyapatite were carried out to optimize the simulated wasteform composition. The phases were characterized by powder X-ray diffraction, FT-IR, TGA, SEM-EDS, and HT-XRD techniques. The results revealed the effect of ionic substitutions on the structure and thermal expansion behavior. The investigation resulted in the formulation of simulated wasteforms such as La3...
May 17, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29770668/-surveillance-of-soil-borne-nematodiasis-in-population-in-hefei-city-2012-2015
#7
Pan Xiao-Xiang, An Jin-Sheng, Zhu Li, Wei Hong-Sheng
OBJECTIVE: To analyze the surveillance results of soil-borne nematodiasis in Hefei City from 2012 to 2015, so as to provide the evidence formulating the Hefei "Thirteen-five" parasitic disease prevention strategy. METHODS: The population in monitoring points in Changfeng County, Lujiang City and Chaohu County were investigated for Ascaris lumbricoides , Trichuristrichiura and hookworm infections with Kato-Katz technique every year from 2012 to 2015, and the children aged less than 6 years were checked for Enterobius vermicularis infection by using the cellophane tape method...
February 10, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29769384/meta-research-on-oncology-trials-a-toolkit-for-researchers-with-limited-resources
#8
Rachel P Riechelmann, Julien Péron, Bostjan Seruga, Everardo D Saad
"Meta-research" is a discipline that investigates research practices. Meta-research on clinical trials is an attempt to summarize descriptive and methodological features of published or ongoing clinical trials, including aspects of their implementation, design, analysis, reporting, and interpretation. In this type of investigation, the unit of analysis is a primary source of information about a clinical trial (e.g., published reports, study protocols, or abstracts), with meta-research being a second layer of information that summarizes what is known from various primary sources...
May 16, 2018: Oncologist
https://www.readbyqxmd.com/read/29768450/a-vvwbo-bvo-based-gm-1-1-and-its-parameter-optimization-by-gra-igsa-integration-algorithm-for-annual-power-load-forecasting
#9
Lianhui Li, Hongguang Wang
Annual power load forecasting is not only the premise of formulating reasonable macro power planning, but also an important guarantee for the safety and economic operation of power system. In view of the characteristics of annual power load forecasting, the grey model of GM (1,1) are widely applied. Introducing buffer operator into GM (1,1) to pre-process the historical annual power load data is an approach to improve the forecasting accuracy. To solve the problem of nonadjustable action intensity of traditional weakening buffer operator, variable-weight weakening buffer operator (VWWBO) and background value optimization (BVO) are used to dynamically pre-process the historical annual power load data and a VWWBO-BVO-based GM (1,1) is proposed...
2018: PloS One
https://www.readbyqxmd.com/read/29767311/developing-a-non-point-source-p-loss-indicator-in-r-and-its-parameter-uncertainty-assessment-using-glue-a-case-study-in-northern-china
#10
Jingjun Su, Xinzhong Du, Xuyong Li
Uncertainty analysis is an important prerequisite for model application. However, the existing phosphorus (P) loss indexes or indicators were rarely evaluated. This study applied generalized likelihood uncertainty estimation (GLUE) method to assess the uncertainty of parameters and modeling outputs of a non-point source (NPS) P indicator constructed in R language. And the influences of subjective choices of likelihood formulation and acceptability threshold of GLUE on model outputs were also detected. The results indicated the following...
May 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29767105/techniques-for-evaluating-digestibility-of-energy-amino-acids-phosphorus-and-calcium-in-feed-ingredients-for-pigs
#11
REVIEW
Fengrui Zhang, Olayiwola Adeola
Sound feed formulation is dependent upon precise evaluation of energy and nutrients values in feed ingredients. Hence the methodology to determine the digestibility of energy and nutrients in feedstuffs should be chosen carefully before conducting experiments. The direct and difference procedures are widely used to determine the digestibility of energy and nutrients in feedstuffs. The direct procedure is normally considered when the test feedstuff can be formulated as the sole source of the component of interest in the test diet...
December 2017: Animal nutrition
https://www.readbyqxmd.com/read/29766941/idiopathic-inflammatory-myopathies-in-adults-a-comparative-study-of-bohan-and-peter-and-european-neuromuscular-center-2004-criteria
#12
Sundaram Challa, Saumya Jakati, Megha S Uppin, Meena A Kannan, Rajasekhar Liza, M K Murthy Jagarlapudi
Background: Bohan and Peter criteria are widely used for the diagnosis of idiopathic inflammatory myopathies (IIMs). Recently, European Neuromuscular Center (ENMC) formulated criteria to identify subgroups of IIMs. Aim: To compare the two diagnostic criteria in adult IIMs. Materials and Methods: This was a retrospective review of case records of histologically confirmed IIMs in adults between January 2014 and May 2015. Both the Bohan and Peter, and ENMC 2004 criteria were applied in the same group of patients to subgroup the IIMs...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29765787/liver-failure-and-conjugated-hyperbilirubinemia-in-a-preterm-neonate-role-of-early-ivig-and-exchange-transfusion
#13
Jayasree Nair, Vasantha H S Kumar
Neonatal liver failure (NLF) is a rare diagnosis but carries with it significant risks of mortality and morbidity. Common etiologies for NLF include metabolic causes, gestational alloimmune liver disease (GALD or neonatal hemochromatosis), and viral infections. We report a case of liver failure in a premature infant with abnormal iron profile within 48 hours of birth. Lack of accepted guidelines for the initial management of severe jaundice with a high direct component in the first week after birth made treatment challenging...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29764431/cyclooxygenase-2-immunoexpression-in-intestinal-epithelium-and-lamina-propria-of-cats-with-inflammatory-bowel-disease-and-low-grade-alimentary-lymphoma
#14
Jorge Castro-López, Antonio Ramis, Marta Planellas, Mariana Teles, Josep Pastor
BACKGROUND: Cyclooxygenase 2 (COX-2) is an inducible isoform by cellular activation, proinflammatory cytokines and growth factors. The aims of the current study were to evaluate COX-2 immunoexpression in epithelial and lamina propria (LP) of cats with inflammatory bowel disease (IBD) and low grade alimentary lymphoma (LGAL), as well as to correlate them with clinical signs and histopathological scoring. Cats diagnosed with IBD and LGAL (2007-2013) were included in the current study. Feline chronic enteropathy activity index (FCEAI) was calculated for all cases...
May 15, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29764362/gpu-accelerated-iterative-reconstruction-for-limited-data-tomography-in-cbct-systems
#15
Claudia de Molina, Estefania Serrano, Javier Garcia-Blas, Jesus Carretero, Manuel Desco, Monica Abella
BACKGROUND: Standard cone-beam computed tomography (CBCT) involves the acquisition of at least 360 projections rotating through 360 degrees. Nevertheless, there are cases in which only a few projections can be taken in a limited angular span, such as during surgery, where rotation of the source-detector pair is limited to less than 180 degrees. Reconstruction of limited data with the conventional method proposed by Feldkamp, Davis and Kress (FDK) results in severe artifacts. Iterative methods may compensate for the lack of data by including additional prior information, although they imply a high computational burden and memory consumption...
May 15, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29762625/an-asymmetric-fitting-function-for-condensed-phase-raman-spectroscopy
#16
Vitaly I Korepanov, Daria M Sedlovets
Asymmetric lineshapes are experimentally observed in the Raman spectra of different classes of condensed matter. Determination of the peak parameters, typically done with symmetric pseudo-Voigt functions, in such situations yields unreliable results. While a wide choice of asymmetric fitting functions is possible, for the function to be practically useful, it should satisfy several criteria: simple analytic form, minimum parameters, description of the symmetric shape as "zero case", estimation of the desired peak parameters in a straightforward way and, above all, adequate description of the experimental data...
May 15, 2018: Analyst
https://www.readbyqxmd.com/read/29762082/predicting-and-optimizing-microswimmer-performance-from-the-hydrodynamics-of-its-components-the-relevance-of-interactions
#17
Nicola Giuliani, Luca Heltai, Antonio DeSimone
Interest in the design of bioinspired robotic microswimmers is growing rapidly, motivated by the spectacular capabilities of their unicellular biological templates. Predicting the swimming speed and efficiency of such devices in a reliable way is essential for their rational design, and to optimize their performance. The hydrodynamic simulations needed for this purpose are demanding and simplified models that neglect nonlocal hydrodynamic interactions (e.g., resistive force theory for slender, filament-like objects that are the typical propulsive apparatus for unicellular swimmers) are commonly used...
May 15, 2018: Soft Robotics
https://www.readbyqxmd.com/read/29761902/the-influence-of-implant-abutment-connection-to-peri-implant-bone-loss-a-systematic-review-and-meta-analysis
#18
REVIEW
Riccardo Caricasulo, Luciano Malchiodi, Paolo Ghensi, Giuliano Fantozzi, Alessandro Cucchi
PURPOSE: Different implant-abutment connections are available and it has been claimed they could have an effect on marginal bone loss. The aim of this review is to establish if implant connection configuration influences peri-implant bone loss (PBL) after functional loading. METHODS: A specific question was formulated according to the Population, Intervention, Control, and Outcome (PICO): Does the type of implant-abutment connection (external, internal, or conical) have an influence on peri-implant bone loss? A PubMed/MEDLINE electronic search was conducted to identify English language publications published in international journals during the last decade (from 2006 to 2016)...
May 15, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29758600/unified-picture-of-strong-coupling-stochastic-thermodynamics-and-time-reversals
#19
Erik Aurell
Strong-coupling statistical thermodynamics is formulated as the Hamiltonian dynamics of an observed system interacting with another unobserved system (a bath). It is shown that the entropy production functional of stochastic thermodynamics, defined as the log ratio of forward and backward system path probabilities, is in a one-to-one relation with the log ratios of the joint initial conditions of the system and the bath. A version of strong-coupling statistical thermodynamics where the system-bath interaction vanishes at the beginning and at the end of a process is, as is also weak-coupling stochastic thermodynamics, related to the bath initially in equilibrium by itself...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29757665/comparison-of-compounded-generic-and-innovator-formulated-itraconazole-in-dogs-and-cats
#20
Janelle Renschler, Amanda Albers, Hanna Sinclair-Mackling, Lawrence Joseph Wheat
The triazole antifungal itraconazole may be cost prohibitive in brand name form; therefore, compounded and generic products are often used as alternatives. Itraconazole blood concentrations have not been studied in clinical patients receiving these formulations. Itraconazole bioassay was performed on serum/plasma from 95 dogs and 20 cats receiving itraconazole (compounded from bulk powder, generic pelletized, or brand name) for systemic mycosis treatment. Mean itraconazole concentration was lower in the compounded group (n = 42) as compared with the generic (n = 40) or brand name (n = 33) groups (0...
May 14, 2018: Journal of the American Animal Hospital Association
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