keyword
MENU ▼
Read by QxMD icon Read
search

Case formulation

keyword
https://www.readbyqxmd.com/read/27904452/virtual-modelling-of-novel-applicator-prototypes-for-cervical-cancer-brachytherapy
#1
Primoz Petric, Robert Hudej, Noora Al-Hammadi, Barbara Segedin
BACKGROUND: Standard applicators for cervical cancer Brachytherapy (BT) do not always achieve acceptable balance between target volume and normal tissue irradiation. We aimed to develop an innovative method of Target-volume Density Mapping (TDM) for modelling of novel applicator prototypes with optimal coverage characteristics. Patients and methods. Development of Contour-Analysis Tool 2 (CAT-2) software for TDM generation was the core priority of our task group. Main requests regarding software functionalities were formulated and guided the coding process...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27904243/a-systematic-approach-to-patients-with-jaundice
#2
REVIEW
Bilal Gondal, Andrew Aronsohn
Jaundice is a clinical manifestation of disorders of underlying bilirubin metabolism, hepatocellular dysfunction, or biliary obstruction. As clinical presentations of yellowing of eyes or skin can be somewhat nonspecific for the underlying etiology of disease, a stepwise approach to evaluation is necessary for accurate diagnosis and effective treatment plan. In this review, we discuss underlying mechanisms of cholestasis and jaundice as well as laboratory and imaging modalities needed to evaluate a patient presenting with hyperbilirubinemia...
December 2016: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/27900588/modeling-informatics-at-vertex-pharmaceuticals-incorporated-our-philosophy-for-sustained-impact
#3
Georgia McGaughey, W Patrick Walters
Molecular modelers and informaticians have the unique opportunity to integrate cross-functional data using a myriad of tools, methods and visuals to generate information. Using their drug discovery expertise, information is transformed to knowledge that impacts drug discovery. These insights are often times formulated locally and then applied more broadly, which influence the discovery of new medicines. This is particularly true in an organization where the members are exposed to projects throughout an organization, such as in the case of the global Modeling & Informatics group at Vertex Pharmaceuticals...
November 29, 2016: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/27898881/effects-of-tallow-choice-white-grease-palm-oil-corn-oil-or-soybean-oil-on-apparent-total-tract-digestibility-of-minerals-in-diets-fed-to-growing-pigs
#4
L A Merriman, C L Walk, C M Parsons, H H Stein
An experiment was conducted to determine the effect of supplementing diets fed to growing pigs with fat sources differing in their composition of fatty acids on the apparent total tract digestibility (ATTD) of minerals. A diet based on corn, potato protein isolate, and 7% sucrose was formulated. Five additional diets that were similar to the previous diet with the exception that sucrose was replaced by 7% tallow, choice white grease, palm oil, corn oil, or soybean oil were also formulated. Diets were formulated to contain 0...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898585/growth-and-development-in-children-with-classic-congenital-adrenal-hyperplasia
#5
Walter Bonfig
PURPOSE OF REVIEW: Final height outcome in classic congenital adrenal hyperplasia (CAH) has been of interest for many years. With analysis of growth patterns and used glucocorticoid regimens, enhanced treatment strategies have been developed and are still under development. RECENT FINDINGS: Most of the current reports on final height outcome are confirmative of previous results. Final height data is still reported in cohorts that were diagnosed clinically and not by newborn screening...
November 24, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27898136/pharmacological-approaches-for-the-management-of-persistent-pain-in-older-adults-what-nurses-need-to-know
#6
Fabio Guerriero, Ruth Bolier, Janet H Van Cleave, M Cary Reid
HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS 1.4 contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo...
December 1, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27896873/identifying-fallacious-arguments-in-a-qualitative-study-of-antipsychotic-prescribing-in-dementia
#7
Parastou Donyai
BACKGROUND: Dementia can result in cognitive, noncognitive and behavioural symptoms which are difficult to manage. Formal guidelines for the care and management of dementia in the UK state that antipsychotics should only be prescribed where fully justified. This is because inappropriate use, particularly problematic in care-home settings, can produce severe side effects including death. The aim of this study was to explore the use of fallacious arguments in professionals' deliberations about antipsychotic prescribing in dementia in care-home settings...
November 29, 2016: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27896684/use-of-spray-dried-dispersions-in-early-pharmaceutical-development-theoretical-and-practical-challenges
#8
Jinjiang Li, Dhaval Patel, George Wang
Spray-dried dispersions (SDDs) have become an important formulation technology for the pharmaceutical product development of poorly water-soluble (PWS) compounds. Although this technology is now widely used in the industry, especially in the early-phase development, the lack of mechanistic understanding still causes difficulty in selecting excipients and predicting stability of SDD-based drug products. In this review, the authors aim to discuss several principles of polymer science pertaining to the development of SDDs, in terms of selecting polymers and solvents, optimizing drug loading, as well as assessing physical stability on storage and supersaturation maintenance after dissolution, from both thermodynamic and kinetic considerations...
November 28, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27891261/perioprosthetic-and-implant-supported-rehabilitation-of-complex-cases-clinical-management-and-timing-strategy
#9
Luca Landi, Stefano Piccinelli, Roberto Raia, Fabio Marinotti, Paolo Francesco Manicone
Treatment of complex perioprosthetic cases is one of the clinical challenges of everyday practice. Only a complete and thorough diagnostic setup may allow the clinician to formulate a realistic prognosis to select the abutments to support prosthetic rehabilitation. Clinical, radiographic, or laboratory parameters used separately are useless to correctly assign a reliable prognosis to single teeth except in the case of a clearly hopeless tooth. Therefore, it is crucial to gather the greatest quantity of data to determine the role that every single element can play in the prosthetic rehabilitation of the case...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27890595/the-formation-and-physical-stability-of-two-phase-solid-dispersion-systems-of-indomethacin-in-supercooled-molten-mixtures-with-different-matrix-formers
#10
Kristian Semjonov, Karin Kogermann, Ivo Laidmäe, Osmo Antikainen, Clare J Strachan, Henrik Ehlers, Jouko Yliruusi, Jyrki Heinämäki
Amorphous solid dispersions (SDs) are a promising approach to improve the dissolution rate of and oral bioavailability of poorly water-soluble drugs. In some cases multi-phase, instead of single-phase, SD systems with amorphous drug are obtained. While it is widely assumed that one-phase amorphous systems are desirable, two-phase systems may still potentially exhibit enhanced stability and dissolution advantages over undispersed systems. The objective of the present study was to understand the solid-state properties of two-phase SDs with amorphous drug and their relation to physical stability...
November 23, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27890544/persistent-hydrocephalus-due-to-postural-activation-of-a-ventricular-shunt-anti-gravity-device
#11
Claudia L Craven, Ahmed K Toma, Laurence D Watkins
The ever present need to balance over drainage with under drainage in hydrocephalus has required innovations including adjustable valves with antigravity devices. These are activated in the vertical position to prevent siphoning. We describe a group of bedridden patients who presented with unexplained under drainage caused by activation of antigravity shunt components produced by peculiar head/body position. Retrospective single centre case series of hydrocephalus patients, treated with ventriculo-peritoneal (VP) shunt insertion between April 2014 - February 2016...
November 24, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27890245/mathematical-models-for-controlled-drug-release-through-ph-responsive-polymeric-hydrogels
#12
Ramya D Manga, Prateek K Jha
Hydrogels consisting of weakly charged acidic/basic groups are ideal candidates for carriers in oral delivery, as they swell in response to pH changes in the gastrointestinal tract, resulting in drug entrapment at low pH conditions of the stomach and drug release at high pH conditions of the intestine. We have developed 1-dimensional mathematical models to study the drug release behavior through pH-responsive hydrogels. Models are developed for 3 different cases that vary in the level of rigor, which together can be applied to predict both in vitro (drug release from carrier) and in vivo (drug concentration in the plasma) behavior of hydrogel-drug formulations...
November 24, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27888785/hallux-varus-following-scarf-osteotomy
#13
Shahid Akhtar, Sabur Malek, Kartik Hariharan
Hallux varus is an uncommon condition and majority of the cases are iatrogenic. It can occur as a result of any type of hallux valgus correction surgery and in our cases scarf osteotomy is not an exception. Treatment of this complication can be challenging and it is important to understand the factors that cause this deformity before embarking on surgical correction. Four cases of hallux varus following Scarf osteotomy (1% of our total Scarf osteotomy cases) and discuss the salient features of these patients...
September 19, 2016: Foot
https://www.readbyqxmd.com/read/27888483/modeling-the-key-factors-that-could-influence-the-diffusion-of-co2-from-a-wellbore-blowout-in-the-ordos-basin-china
#14
Qi Li, Hui Shi, Duoxing Yang, Xiaochen Wei
Carbon dioxide (CO2) blowout from a wellbore is regarded as a potential environment risk of a CO2 capture and storage (CCS) project. In this paper, an assumed blowout of a wellbore was examined for China's Shenhua CCS demonstration project. The significant factors that influenced the diffusion of CO2 were identified by using a response surface method with the Box-Behnken experiment design. The numerical simulations showed that the mass emission rate of CO2 from the source and the ambient wind speed have significant influence on the area of interest (the area of high CO2 concentration above 30,000 ppm)...
November 26, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27887665/in-the-eye-of-the-beholder-to-make-global-health-estimates-useful-make-them-more-socially-robust
#15
Elizabeth Pisani, Maarten Kok
A plethora of new development goals and funding institutions have greatly increased the demand for internationally comparable health estimates in recent years and have brought important new players into the field of health estimate production. These changes have rekindled debates about the validity and legitimacy of global health estimates. This paper draws on country case studies and personal experience to support our opinion that the production and use of estimates are deeply embedded in specific social, economic, political, and ideational contexts, which vary at different levels of the global health architecture...
2016: Global Health Action
https://www.readbyqxmd.com/read/27886071/case-formulation-in-young-people-with-post-traumatic-stress-disorder-and-first-episode-psychosis
#16
Emma Halpin, Vanessa Kugathasan, Carol Hulbert, Mario Alvarez-Jimenez, Sarah Bendall
BACKGROUND: Evidence based treatment interventions for young people with first-episode psychosis (FEP) and trauma histories is lacking. Although case formulation (CF) has been widely regarded in cognitive behavioural therapy manuals as beneficial, there is limited empirical research examining how clients and therapists experience the process. AIM: This study aimed to explore young people's reactions to CF in treatment for PTSD (post-traumatic stress disorder) and FEP...
November 23, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27884520/environmental-benignity-of-a-pesticide-in-soft-colloidal-hydrodispersive-nanometric-form-with-improved-toxic-precision-towards-the-target-organisms-than-non-target-organisms
#17
A P B Balaji, Thotapalli P Sastry, Subramani Manigandan, Amitava Mukherjee, Natarajan Chandrasekaran
Mosquito-borne diseases are of major concern as they cause devastating health effects, morbidity, and mortality in the human population. Conventional pesticides have failed to curb the mosquito population due to the development of insensitivity in mosquitoes. Hence, higher dosages of pesticides along with their toxic solubilizers have been employed, which have led to raise in pesticide pollution load, environmental toxicity, and human health concerns. As a realisation for the requirement of alternative pesticides, the present study has involved in the formulation of a hydrodispersive nanometric colloidal form of deltamethrin (NDM), a type-II pyrethroid pesticide, from its hydroimmisicible parental form (PDM)...
November 21, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27882445/enhanced-dietary-formulation-to-mitigate-winter-thermal-stress-in-gilthead-sea-bream-sparus-aurata-a-2d-dige-plasma-proteome-study
#18
Denise Schrama, Nadège Richard, Tomé S Silva, Filipe A Figueiredo, Luís E C Conceição, Richard Burchmore, David Eckersall, Pedro M L Rodrigues
Low water temperatures during winter are common in farming of gilthead sea bream in the Mediterranean. This causes metabolic disorders that in extreme cases can lead to a syndrome called "winter disease." An improved immunostimulatory nutritional status might mitigate the effects of this thermal metabolic stress. A trial was set up to assess the effects of two different diets on gilthead sea bream physiology and nutritional state through plasma proteome and metabolites. Four groups of 25 adult gilthead sea bream were reared during winter months, being fed either with a control diet (CTRL) or with a diet called "winter feed" (WF)...
November 24, 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/27880836/towards-the-automatic-classification-of-avian-flight-calls-for-bioacoustic-monitoring
#19
Justin Salamon, Juan Pablo Bello, Andrew Farnsworth, Matt Robbins, Sara Keen, Holger Klinck, Steve Kelling
Automatic classification of animal vocalizations has great potential to enhance the monitoring of species movements and behaviors. This is particularly true for monitoring nocturnal bird migration, where automated classification of migrants' flight calls could yield new biological insights and conservation applications for birds that vocalize during migration. In this paper we investigate the automatic classification of bird species from flight calls, and in particular the relationship between two different problem formulations commonly found in the literature: classifying a short clip containing one of a fixed set of known species (N-class problem) and the continuous monitoring problem, the latter of which is relevant to migration monitoring...
2016: PloS One
https://www.readbyqxmd.com/read/27879965/a-therapeutic-approach-to-paediatric-oral-disorders
#20
Enrico Calcagno, Dionisio F Barattini, Roberto Servetto
The promotion of oral health in paediatrics stands as an institutional requirement in countries such as Italy where children's dental disorders still register a high incidence in spite of high levels of general health. Guidelines indicate the need to target a large age group and stress the relevance of parental education, whom paediatricians and dentists should address to. In this respect, teething is paradigmatic, due to the interactions between inflammation of the gingival mucosa, the possible associations with systemic symptoms as well as the psychological parental component...
November 23, 2016: Minerva Pediatrica
keyword
keyword
27987
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"