keyword
MENU ▼
Read by QxMD icon Read
search

Case formulation

keyword
https://www.readbyqxmd.com/read/28922416/multi-level-computational-methods-for-interdisciplinary-research-in-the-hathitrust-digital-library
#1
Jaimie Murdock, Colin Allen, Katy Börner, Robert Light, Simon McAlister, Andrew Ravenscroft, Robert Rose, Doori Rose, Jun Otsuka, David Bourget, John Lawrence, Chris Reed
We show how faceted search using a combination of traditional classification systems and mixed-membership topic models can go beyond keyword search to inform resource discovery, hypothesis formulation, and argument extraction for interdisciplinary research. Our test domain is the history and philosophy of scientific work on animal mind and cognition. The methods can be generalized to other research areas and ultimately support a system for semi-automatic identification of argument structures. We provide a case study for the application of the methods to the problem of identifying and extracting arguments about anthropomorphism during a critical period in the development of comparative psychology...
2017: PloS One
https://www.readbyqxmd.com/read/28919470/preparation-and-characterization-of-amorphous-ciprofloxacin-amino-acid-salts
#2
Hanah Mesallati, Daryl Conroy, Sarah Hudson, Lidia Tajber
The amorphization of the poorly soluble drug ciprofloxacin (CIP) may be facilitated by the use of a suitable stabilizer. In this study seven amino acids, with various side chain properties, were evaluated in this regard. Solid dispersions were prepared by ball milling 1:1 molar ratios of CIP with the amino acids, and their solid-state and pharmaceutical properties were then examined. Fully X-ray amorphous solid dispersions were obtained with aspartic acid, glutamic acid, cysteine and arginine. In each case, evidence of salt formation between the drug and amino acids was found via Fourier transform infrared spectroscopy and solid-state nuclear magnetic resonance...
September 14, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28919099/development-of-an-abiraterone-acetate-formulation-with-improved-oral-bioavailability-guided-by-absorption-modeling-based-on-in-vitro-dissolution-and-permeability-measurements
#3
Tamás Solymosi, Zsolt Ötvös, Réka Angi, Betti Ordasi, Tamás Jordán, Sándor Semsey, László Molnár, Soma Ránky, Genovéva Filipcsei, Gábor Heltovics, Hristos Glavinas
Particle size reduction of drug crystals in the presence of surfactants (often called "top-down" production methods) is a standard approach used in the pharmaceutical industry to improve bioavailability of poorly soluble drugs. Based on the mathematical model used to predict the fraction dose absorbed this formulation approach is successful when dissolution rate is the main rate limiting factor of oral absorption. In case compound solubility is also a major factor this approach might not result in an adequate improvement in bioavailability...
September 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28919082/diabetes-mellitus-and-obesity-as-risk-factors-for-pancreatic-cancer
#4
Guido Eibl, Zobeida Cruz-Monserrate, Murray Korc, Maxim S Petrov, Mark O Goodarzi, William E Fisher, Aida Habtezion, Aurelia Lugea, Stephen J Pandol, Phil A Hart, Dana K Andersen
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030...
September 11, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28918570/mathematical-description-of-drug-target-interactions-application-to-biologics-that-bind-to-targets-with-two-binding-sites
#5
Leonid Gibiansky, Ekaterina Gibiansky
The emerging discipline of mathematical pharmacology occupies the space between advanced pharmacometrics and systems biology. A characteristic feature of the approach is application of advance mathematical methods to study the behavior of biological systems as described by mathematical (most often differential) equations. One of the early application of mathematical pharmacology (that was not called this name at the time) was formulation and investigation of the target-mediated drug disposition (TMDD) model and its approximations...
September 16, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28917989/shear-strength-of-pharmaceutical-tablets-theoretical-considerations-evaluation-and-relation-with-the-capping-tendency-of-biconvex-tablets
#6
V Mazel, H Diarra, V Busignies, P Tchoreloff
Capping is a major industrial issue during pharmaceutical powder compression, especially in the case of biconvex tablets. Several articles proposed that capping was in fact a failure in shear. Shear strength should thus be interesting to study the capping tendency of a formulation. In this work, the ratio between the shear strength and the tensile strength obtained by diametral compression was first studied from a theoretical point of view considering different failure criteria. Then, a shear test usually performed on bilayer tablets was adapted to monolayer tablets...
September 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28916468/dermal-absorption-for-pesticide-health-risk-assessment-harmonization-of-study-design-and-data-reporting-for-north-american-regulatory-submissions
#7
Kristie M Sullivan, Manoj Aggarwal, Jonathan M Akins, Eric Fabian, Jon R Heylings, Hans Raabe, P V Shah, Christiane Wiemann, Richard Peffer
Although an internationally-adopted in vitro dermal absorption test guideline is available (OECD Test Guideline 428), the replacement of the in vivo approach in North America for pesticide formulations has not occurred due to concern over the reliability and consistency of the in vitro results. A 2012 workshop convened a panel of experts in the conduct of in vitro studies used for pesticide risk assessment, together with North American regulators, to examine techniques for in vitro dermal absorption testing...
September 12, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28914753/on-optimal-cooperative-sensing-with-energy-detection-in-cognitive-radio
#8
Sunghwan Bae, Jaewoo So, Hongseok Kim
In this paper, we propose an optimal cooperative sensing technique for cognitive radio to maximize sensing performance based on energy detection. In most spectrum sensing research, many cooperation methods have been proposed to overcome the sensitivity of energy detection so that both primary and secondary users are better off in terms of spectral efficiency. However, without assigning a proper sensing threshold to each sensing node, cooperation may not be effective unless the received average primary user signal-to-noise ratio (SNR) is identical...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28913330/resurgence-of-diphtheria-in-north-kerala-india-2016-laboratory-supported-case-based-surveillance-outcomes
#9
Lucky Sangal, Sudhir Joshi, Shalini Anandan, Veeraraghavan Balaji, Jaichand Johnson, Asish Satapathy, Pradeep Haldar, Ramesh Rayru, Srinath Ramamurthy, Asha Raghavan, Pankaj Bhatnagar
INTRODUCTION: As part of national program, laboratory supported vaccine preventable diseases surveillance was initiated in Kerala in 2015. Mechanisms have been strengthened for case investigation, reporting, and data management. Specimens collected and sent to state and reference laboratories for confirmation and molecular surveillance. The major objective of this study is to understand the epidemiological information generated through surveillance system and its utilization for action...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28912027/factor-analysis-in-optimization-of-formulation-of-high-content-uniformity-tablets-containing-low-dose-active-substance
#10
Ivana Lukášová, Jan Muselík, Aleš Franc, Roman Goněc, Filip Mika, David Vetchý
Warfarin is intensively discussed drug with narrow therapeutic range. There have been cases of bleeding attributed to varying content or altered quality of the active substance. Factor analysis is useful for finding suitable technological parameters leading to high content uniformity of tablets containing low amount of active substance. The composition of tabletting blend and technological procedure were set with respect to factor analysis of previously published results. The correctness of set parameters was checked by manufacturing and evaluation of tablets containing 1-10mg of warfarin sodium...
September 11, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28911657/convenient-uv-spectrophotometric-determination-of-citrates-in-aqueous-solutions-with-applications-in-the-pharmaceutical-analysis-of-oral-electrolyte-formulations
#11
Sylwester Krukowski, Mateusz Karasiewicz, Waclaw Kolodziejski
Herein, we present a convenient method for quantitative spectrophotometric determination of citrate ions in aqueous solutions in the middle-UV range. It involves measuring the absorbance of citric acid at 209 nm under suppressed dissociation at pH < 1.0 in the presence of hydrochloric acid. Validation of the method was performed according to the guidelines of the International Conference on Harmonization. A very good linear dependence of the absorbance on concentration (r(2) = 0.9999) was obtained in a citrate concentration range of 0...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911324/leadership-and-governance-of-community-health-worker-programmes-at-scale-a-cross-case-analysis-of-provincial-implementation-in-south-africa
#12
Helen Schneider, Nonhlanhla Nxumalo
BACKGROUND: National community health worker (CHW) programmes are returning to favour as an integral part of primary health care systems, often on the back of pre-existing community based initiatives. There are significant challenges to the integration and support of such programmes, and they require coordination and stewardship at all levels of the health system. This paper explores the leadership and governance tasks of large-scale CHW programmes at sub-national level, through the case of national reforms to South Africa's community based sector, referred to as the Ward Based Outreach Team (WBOT) strategy...
September 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28906086/new-formulation-for-topical-treatment-of-onychomycoses
#13
Elisa M Difonzo, Federica Scarfì, Massimiliano Galeone
BACKGROUND: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28905916/hardware-efficient-variational-quantum-eigensolver-for-small-molecules-and-quantum-magnets
#14
Abhinav Kandala, Antonio Mezzacapo, Kristan Temme, Maika Takita, Markus Brink, Jerry M Chow, Jay M Gambetta
Quantum computers can be used to address electronic-structure problems and problems in materials science and condensed matter physics that can be formulated as interacting fermionic problems, problems which stretch the limits of existing high-performance computers. Finding exact solutions to such problems numerically has a computational cost that scales exponentially with the size of the system, and Monte Carlo methods are unsuitable owing to the fermionic sign problem. These limitations of classical computational methods have made solving even few-atom electronic-structure problems interesting for implementation using medium-sized quantum computers...
September 13, 2017: Nature
https://www.readbyqxmd.com/read/28905162/quality-of-prescribing-in-community-dwelling-elderly-patients-in-france-an-observational-study-in-community-pharmacies
#15
E Bourcier, F Mille, V Brunie, V Korb-Savoldelli, C Lafortune, M Buyse, C Fernandez, P Hindlet
Background In order to ensure safer prescriptions in the elderly, lists of potentially inappropriate medications (PIMs) and guidelines have been introduced. Whereas the effectiveness of these measures has been well studied in hospitals, data are sparse for the community-dwelling patients. Objective To assess the quality of prescriptions among community-dwelling elderly patients, and potential associations between prescription patterns, patient characteristics and medication adherence. Setting Community pharmacies in France...
September 14, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28903312/gnp-gapdh1-22-nanovaccines-prevent-neonatal-listeriosis-by-blocking-microglial-apoptosis-and-bacterial-dissemination
#16
Ricardo Calderon-Gonzalez, Elisabet Frande-Cabanes, Hector Teran-Navarro, José María Marimon, Javier Freire, David Salcines-Cuevas, M Carmen Fariñas, Claudia Onzalez-Rico, Marco Marradi, Isabel Garcia, Mirian Alkorta-Gurrutxaga, Aida San Nicolas-Gomez, Ana Castañeda-Sampedro, Sonsoles Yañez-Diaz, Soledad Penades, Carmen Punzon, Javier Gomez-Roman, Fernando Rivera, Manuel Fresno, Carmen Alvarez-Dominguez
Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902008/fibrous-catalyst-enhanced-acanthamoeba-disinfection-by-hydrogen-peroxide
#17
Simon Kilvington, Lynn Winterton
SIGNIFICANCE: Hydrogen peroxide (H2O2) disinfection systems are contact-lens-patient problem solvers. The current one-step, criterion-standard version has been widely used since the mid-1980s, without any significant improvement. This work identifies a potential next-generation, one-step H2O2, not based on the solution formulation but rather on a case-based peroxide catalyst. PURPOSE: One-step H2O2 systems are widely used for contact lens disinfection. However, antimicrobial efficacy can be limited because of the rapid neutralization of the peroxide from the catalytic component of the systems...
September 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28901534/evaluation-of-the-efficacy-and-safety-of-oral-isotretinoin-versus-topical-isotretinoin-in-the-treatment-of-plane-warts-a-randomized-open-trial
#18
Gagan J Kaur, Balvinder K Brar, Sumir Kumar, Sukhmani K Brar, Baltej Singh
BACKGROUND: Plane warts are a common therapeutic problem. Our aim was to assess the efficacy and safety of oral versus topical isotretinoin in the treatment of plane warts. METHODS: Forty patients with multiple plane warts were randomized into two groups. Group A was treated with oral isotretinoin capsules in the dose of 0.5 mg/kg/d and Group B with topical isotretinoin 0.05% in gel formulation once daily at night. Treatment was given to the patients for 3 months or until the complete clearance of lesions, whichever was earlier...
September 13, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28899371/simultaneous-detection-of-%C3%AE-lactoalbumin-%C3%AE-lactoglobulin-and-lactoferrin-in-milk-by-visualized-microarray
#19
Zhoumin Li, Fang Wen, Zhonghui Li, Nan Zheng, Jindou Jiang, Danke Xu
BACKGROUND: α-Lactalbumin (a-LA), β-lactoglobulin (β-LG) and lactoferrin (LF) are of high nutritional value which have made ingredients of choice in the formulation of modern foods and beverages. There remains an urgent need to develop novel biosensing methods for quantification featuring reduced cost, improved sensitivity, selectivity and more rapid response, especially for simultaneous detection of multiple whey proteins. RESULTS: A novel visualized microarray method was developed for the determination of a-LA, β-LG and LF in milk samples without the need for complex or time-consuming pre-treatment steps...
September 12, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28898420/characterization-of-hyperbranched-core-multishell-nanocarriers-as-an-innovative-drug-delivery-system-for-the-application-at-the-oral-mucosa
#20
J Jager, K Obst, S B Lohan, J Viktorov, S Staufenbiel, H Renz, M Unbehauen, R Haag, S Hedtrich, C Teutloff, M C Meinke, K Danker, H Dommisch
BACKGROUND AND OBJECTIVES: In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approach. However, their efficacy is limited. Dilution effects due to saliva hinder the adherence and the penetration of drug formulations. Therefore, the bioavailability of oral topical drugs is insufficient, and patients may suffer from disease over years, if not life-long...
September 12, 2017: Journal of Periodontal Research
keyword
keyword
27987
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"