Romain Muller, Raphael Cauchois, Marie Lagarde, Sandrine Roffino, Cecile Genovesio, Samantha Fernandez, Guillaume Hache, Benjamin Guillet, Yeter Kara, Marion Marlinge, Peter J Lenting, Pascale Poullin, Françoise Dignat-George, Edwige Tellier, Gilles Kaplanski
Thrombotic thrombocytopenic purpura (TTP), a rare but fatal disease if untreated, is due to alteration in Von Willebrand factor cleavage resulting in capillary microthrombi formation and ischemic organ damage. Interleukin-1 (IL-1), has been shown to drive sterile inflammation following ischemia and could play an essential contribution to post-ischemic organ damage in TTP. Our objectives were to evaluate IL-1 involvement during TTP and to test the efficacy of the recombinant IL-1 receptor antagonist, anakinra, in a murine TTP model...
April 5, 2024: Blood