Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
REVIEW
Zih-Yi Sung, Yong-Qi Liao, Jung-Hsiu Hou, Hong-Hsien Lai, Sung-Ming Weng, Hai-Wei Jao, Buo-Jia Lu, Chi-Huang Chen
Recently, there has been increasing emphasis on the gonadotoxic effects of cancer therapy in prepubertal boys. As advances in oncology treatments continue to enhance survival rates for prepubertal boys, the need for preserving their functional testicular tissue for future reproduction becomes increasingly vital. Therefore, we explore cutting-edge strategies in fertility preservation, focusing on the cryopreservation and transplantation of immature testicular tissue as a promising avenue. The evolution of cryopreservation techniques, from controlled slow freezing to more recent advancements in vitrification, with an assessment of their strengths and limitations was exhibited...
April 18, 2024: Reproductive Biology and Endocrinology: RB&E
#22
MULTICENTER STUDY
Michael D Keller, Patrick J Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C Dvorak, Michael R Verneris, Donald B Kohn, Sung-Yun Pai, Blachy J Dávila Saldaña, Benjamin Hanisch, Troy C Quigg, Roberta H Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A Jensen-Wachspress, Christopher A Lazarski, Gelina Sani, John M Idso, Haili Lang, Pamela Chansky, Chase D McCann, Jay Tanna, Allistair A Abraham, Jennifer L Webb, Abeer Shibli, Amy K Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N De Oliveira, Mark T Vander Lugt, Christen L Ebens, Victor M Aquino, Jeffrey J Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T Zambidis, Elizabeth Gourdine, Catherine M Bollard, Michael A Pulsipher
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients with inborn errors of immunity and/or post allogeneic hematopoietic stem cell transplant with refractory viral infections using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus...
April 18, 2024: Nature Communications
#23
JOURNAL ARTICLE
Bao-Fu Yu, Xiao-Xue Chen, Jia Liu, Jin-Guang He, Chuang-Chang Dai, Jiao Wei
SUMMARY: Nasal reconstruction in pediatric patient is very challenging and it requires consideration of later nasal development. Herein, we introduce an innovative preauricular free flap pedicled with retrograde vascular (PFFPRV) for pediatric nasal reconstruction. In this PFFPRV technique, the retrograde superficial temporal vessels were used as the flap pedicle. The lateral alar artery and angular vein were used as vessels of the nasal recipient zone. The flap vessels were anastomosed directly to the recipient area vessels without additional vessel transplantation...
April 18, 2024: Plastic and Reconstructive Surgery
#24
JOURNAL ARTICLE
Lourdes Cordón, Pedro Chorão, Beatriz Martín-Herreros, Juan Montoro, Aitana Balaguer, Manuel Guerreiro, Marta Villalba, Ana Facal, Pedro Asensi, Pilar Solves, Inés Gómez, Marta Santiago, Brais Lamas, Ana Bataller, Pablo Granados, Amparo Sempere, Guillermo F Sanz, Miguel A Sanz, Jaime Sanz
This study aimed to investigate the kinetics of immune recovery following umbilical cord blood transplantation (UCBT) in adults who received a myeloablative conditioning (MAC) regimen and antithymocyte globulin (ATG). While the immune recovery kinetics has been extensively studied in pediatric UCBT recipients, limited data exist for adults. We conducted a comprehensive analysis of 221 consecutive adult patients who underwent UCBT with MAC and ATG at a single institution. Our objective was to evaluate the influence of patient, disease, and transplant factors, along with acute graft-versus-host disease (aGVHD), on immune reconstitution and overall survival...
April 18, 2024: Annals of Hematology
#25
JOURNAL ARTICLE
Sandeep Sainathan, John Ryan, Leonardo Mullinari, Pablo Sanchez
OBJECTIVE: Pediatric Heart-lung transplant (HLTX) is performed for endstage congenital heart disease (CHD) with irreversible pulmonary hypertension or non-congenital heart disease (NCHD) with end-stage heart and lung disease. CHD could influence the outcomes of HTLX due to increased complexity of the operation as compared to NCHD. In this study we evaluated the influence of cardiac diagnosis on outcomes of pediatric HTLX. METHODS: The UNOS database (1987-2022) was queried for primary HTLX in patients <18 years...
April 2024: Clinical Transplantation
#26
JOURNAL ARTICLE
Joseph Burns, Ezinne Emeruwa, Patrick Connell, Nirica Borges, Dana Reaves-O'Neal, Silvana Molossi
Anomalous aortic origin of the left coronary artery (AAOLCA) confers high risk for sudden cardiac arrest (SCA). This series aims to describe consecutive admissions with interarterial AAOLCA presenting with SCA and distinct clinical trajectories. An eight-year-old boy collapsed at school and received 10-min of cardiopulmonary resuscitation (CPR) and defibrillation prior to return of spontaneous circulation. He had no end-organ dysfunction and underwent uneventful coronary unroofing. In contrast, a 14-year-old boy presented with collapse while jogging...
April 17, 2024: World Journal for Pediatric & Congenital Heart Surgery
#27
JOURNAL ARTICLE
Gabriel Salinas Cisneros, Christopher C Dvorak, Janel Long-Boyle, Sandhya Kharbanda, Kristin A Shimano, Alexis Melton, Julia Chu, Lena E Winestone, Jasmeen Dara, James N Huang, Michelle L Hermiston, Matt Zinter, Christine S Higham
INTRODUCTION: Sinusoidal obstructive syndrome (SOS), or veno-occlusive disease (VOD), of the liver has been recognized as a complex, life-threatening complication in the post-hematopoietic stem cell transplant (HSCT) setting. The diagnostic criteria for SOS have evolved over the last several decades with a greater understanding of the underlying pathophysiology, with two recent diagnostic criteria introduced in 2018 (EBMT criteria) and 2020 (Cairo criteria). OBJECTIVE: We sought out to evaluate the performance characteristics in diagnosing and grading SOS in pediatric patients of the four different diagnostic criteria (Baltimore, Modified Seattle, EBMT, and Cairo) and severity grading systems (defined by the EBMT and Cairo criteria)...
April 15, 2024: Transplantation and cellular therapy
#28
JOURNAL ARTICLE
Ana Raquel Claro, Ana Rita Oliveira, Filipa Durão, Patrícia Costa Reis, Ana Rita Sandes, Carla Pereira, José Esteves da Silva
OBJECTIVES: Growth failure is one of the major complications of pediatric chronic kidney disease. Even after a kidney transplant (KT), up to 50 % of patients fail to achieve the expected final height. This study aimed to assess longitudinal growth after KT and identify factors influencing it. METHODS: A retrospective observational study was performed. We reviewed the clinical records of all patients who underwent KT for 25 years in a single center (n=149) and performed telephone interviews...
April 18, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
#29
REVIEW
Pornarun Charoenraj, Zolzaya Chinzorig, Dolgorsuren Adiya, Naiyana Aroonpruksakul, Khuanysh Ayatkhan, Oyun Bayarsaikhan, Odgerel Boldbaatar, Duenpen Horatanaruang, Urantuya Khorolsaikhan, Pornswan Ngamprasertwong, Tumenjargal Purev-Oidov, Solongo Tumur, Justin Skowno
INTRODUCTION AND HISTORY: In Mongolia, pediatric anesthesia has advanced during the past 25 years through expanded, standardized education programs and international collaboration. Pediatric anesthesia is a recognized specialty, covering all surgical services, including cardiac and transplant, using physicians and nurses. TRAINING: The pediatric anesthesia fellowship is 6 months after 2 years of residency; pediatric nurse anesthesia training is 6 months...
April 17, 2024: Paediatric Anaesthesia
#30
JOURNAL ARTICLE
Carla Ramirez-Amoros, Maria San Basilio, Virginia Amesty, Susana Rivas, Roberto Lobato, Carlota Fernandez-Camblor, Pedro Lopez-Pereira, Maria Jose Martinez-Urrutia
BACKGROUND: Renal transplantation is currently the best treatment option for patients with end-stage renal disease. However, the use of kidneys from donors under 6 years of age as a possibility to increase the organ pool in pediatric recipients remains a controversial matter. We aimed to investigate whether donor age is associated to the long-term functionality of the renal graft. Likewise, we analyzed the adaptation of the graft to the ascending functional requirements in the pediatric patient...
May 2024: Pediatric Transplantation
#31
JOURNAL ARTICLE
Alicia Paessler, Colin Forman, Kishore Minhas, Premal Amrishkumar Patel, James Carmichael, Luke Smith, Fayyad Jaradat, Sergio Assia-Zamora, Zainab Arslan, Francis Calder, Samiran Ray, Nicos Kessaris, Jelena Stojanovic
BACKGROUND: 3D printing has been used in different medical contexts, although it is underutilised in paediatrics. We present the first use of 3D printing in the management of three paediatric patients with complex renovascular disease. METHODS: Patient-specific 3D models were produced from conventional 2D imaging and manufactured using 3D polyjet printing technology. All three patients had different underlying pathologies, but all underwent multiple endovascular interventions (renal artery balloon angioplasty) prior to 3D printing and subsequent vascular surgery...
April 16, 2024: Archives of Disease in Childhood
#32
JOURNAL ARTICLE
Hannah W Song, Michaela Prochazkova, Lipei Shao, Roshini Traynor, Sarah Underwood, Mary Black, Vicki Fellowes, Rongye Shi, Marie Pouzolles, Hsien-Chao Chou, Adam T Cheuk, Naomi Taylor, Ping Jin, Robert P Somerville, David F Stroncek, Javed Khan, Steven L Highfill
With investigators looking to expand engineered T cell therapies such as CAR-T to new tumor targets and patient populations, a variety of cell manufacturing platforms have been developed to scale manufacturing capacity using closed and/or automated systems. Such platforms are particularly useful for solid tumor targets, which typically require higher CAR-T cell doses. Although T cell phenotype and function are key attributes that often correlate with therapeutic efficacy, how manufacturing platforms influence the final CAR-T cell product is currently unknown...
March 12, 2024: Cytotherapy
#33
JOURNAL ARTICLE
Johannes Hilberath, Vittoria Camelli, Christiane Hofer, Steffen Hartleif, Silvio Nadalin, Maren Peters, Matthias Kumpf, Andrea Bevot, Matthias Zirngibl, Marcus Weitz, Ekkehard Sturm
OBJECTIVES: Paediatric acute liver failure (PALF) is a life-threatening disease. Management aims to support hepatic regeneration or to bridge to liver transplantation. High-volume plasmapheresis (HVP) removes protein-bound substances, alleviates inflammation, and improves survival in adult acute liver failure. However, experience with HVP in PALF is limited. Aim of this study is to report on feasibility, safety, efficacy and outcomes of HVP in PALF. METHODS: Retrospective observational study in children with PALF...
April 16, 2024: Journal of Pediatric Gastroenterology and Nutrition
#34
REVIEW
Vikram K Raghu, Carolina Rumbo, Simon P Horslen
INTRODUCTION: Intestinal failure, defined as the loss of gastrointestinal function to the point where nutrition cannot be maintained by enteral intake alone, presents numerous challenges in children, not least the timing of consideration of intestine transplantation. OBJECTIVES: To describe the evolution of care of infants and children with intestinal failure including parenteral nutrition, intestine transplantation, and contemporary intestinal failure care. METHODS: The review is based on the authors' experience supported by an in-depth review of the published literature...
May 2024: Pediatric Transplantation
#35
JOURNAL ARTICLE
Damiano Astolfi, Nathalie Rock, Dimitri Ceroni, Barbara E Wildhaber
BACKGROUND: Hepatic osteodystrophy refers to bone disorders associated with chronic liver disease, including children undergoing liver transplantation (LT). The aim of this study was to quantify the prevalence of pathological fractures (PF) in children before and after LT and to identify associated factors for their occurrence. METHODS: Children aged 0-18 years who underwent LT from 1/2005 to 12/2020 were included in this retrospective study. Data on patient demographics, types and anatomical locations of fracture and biological workups were extracted...
May 2024: Pediatric Transplantation
#36
EDITORIAL
Seth A Hollander
No abstract text is available yet for this article.
May 2024: Pediatric Transplantation
#37
Caitlin G Peterson, Rachel L Jackson
BACKGROUND: Kidney transplantation is an acceptable therapy end-stage kidney disease secondary to antineutrophil cytoplasmic antibody-associated vasculitis with risk of disease recurrence ranging from 3% to 17%. Standard posttransplant immunosuppression is the mainstay of therapy after recurrence. Recently, new medications focused on complement regulation and avoidance of steroids have been shown to be effective in treating antineutrophil cytoplasmic antibody (ANCA) vasculitis with no studies in the pediatric population...
May 2024: Pediatric Transplantation
#38
MULTICENTER STUDY
Rachel M Engen, Sharon M Bartosh
BACKGROUND: Alemtuzumab is a lymphocyte depleting agent used for induction in kidney transplant, but long-term information on its use in pediatric recipients remains sparse. METHODS: We performed a single-center retrospective cohort study of 57 pediatric kidney transplant recipients receiving alemtuzumab 20 mg/m2 /dose ×2 doses for induction immunosuppression. All patients underwent surveillance biopsies, and 91.3% underwent steroid withdrawal by day 4 post-transplant...
May 2024: Pediatric Transplantation
#39
JOURNAL ARTICLE
Brian T Fisher, Jesse Blumenstock, Craig L K Boge, Sydney Shuster, Alix E Seif, Michael Green, Marian G Michaels, Jessie L Alexander, Monica I Ardura, Tamara P Miller, Diego R Hijano, William J Muller, Jennifer E Schuster, Abby M Green, Daniel E Dulek, Adriana E Kajon, Lara Danziger-Isakov
BACKGROUND: Pediatric allogeneic hematopoietic cell transplant (allo-HCT) recipients are at risk for morbidity and mortality from human adenovirus (HAdV). HAdV can be detected in an asymptomatic state, referred to as infection or with signs or symptoms of illness, referred to as disease. Standardized case definitions are needed to distinguish infection from disease and allow for consistent reporting in both observational cohort studies and therapeutic clinical trials. METHODS: A working group of experts in virology, transplant infectious disease, and HCT was assembled to develop HAdV infection and disease definitions with the degree of certainty (i...
May 2024: Pediatric Transplantation
#40
JOURNAL ARTICLE
Ulgen Celtik, Zafer Dokumcu, Coskun Ozcan, Orkan Ergün
AIM: Acquired post-transplant diaphragmatic hernia (PTDH) is a rare complication of liver transplantation (LT) in children. We aimed to present our experience in PTDH, and a possible causative background is discussed. METHODS: Medical records of patients who had undergone diaphragmatic repair following LT between 2015 and 2023 were reviewed. Demographic information, details of primary diseases necessitating LT, transplantation techniques, and clinical findings associated with PTDH were evaluated...
May 2024: Pediatric Transplantation
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
