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https://www.readbyqxmd.com/read/29441569/epidemiologic-associations-of-hpv-positive-oropharyngeal-cancer-and-pre-cancerous-cervical-lesions
#1
M M Rietbergen, A A J D van Bokhoven, B I Lissenberg-Witte, D A M Heideman, C R Leemans, R H Brakenhoff, E Bloemena
PURPOSE: Human papillomavirus (HPV)- induced oropharyngeal squamous cell carcinoma (OPSCC) is still increasing worldwide. We aimed to investigate if the HPV-prevalence of OPSCC in the Netherlands is rising as well, especially in female patients. In addition, we evaluated the association between HPV-positive OPSCC and suspicious Pap results of the cervix in these female patients. PATIENTS AND METHODS: Patients with OPSCC treated in the period 2000-2015 at the VU University Medical Center Amsterdam, were included (n=926)...
February 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29440214/-it-has-saved-thousands-of-lives-so-why-change-it-content-analysis-of-objections-to-cervical-screening-programme-changes-in-australia
#2
Helena M Obermair, Rachael H Dodd, Carissa Bonner, Jesse Jansen, Kirsten McCaffery
OBJECTIVES: The incidence and mortality of cervical cancer have halved since introduction of the Australian cervical screening programme in 1991, involving 2-yearly Pap smears from ages 18-69 years. In 2017, the programme changed to 5- yearly primary human papillomavirus (HPV) testing for women aged 25-74 years. This study investigated reasons for opposition to the renewed screening programme within the open-ended comments of an online petition, 'Stop May 1st Changes to Pap Smears-Save Women's Lives', opposing the changes, which received over 70 000 signatures and almost 20 000 comments...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438367/randomised-study-shows-that-repeated-self-sampling-and-hpv-test-has-more-than-two-fold-higher-detection-rate-of-women-with-cin2-histology-than-pap-smear-cytology
#3
Inger Gustavsson, Riina Aarnio, Malin Berggrund, Julia Hedlund-Lindberg, Ann-Sofi Strand, Karin Sanner, Ingrid Wikström, Stefan Enroth, Matts Olovsson, Ulf Gyllensten
BACKGROUND: This randomised study compared the detection rate of cervical intraepithelial neoplasia-positive (CIN2+) based on histology in women performing repeated self-sampling of vaginal fluid (VF) for human papillomavirus (HPV) test with a control group following the ordinary screening by Pap smear cytology. METHODS: 36390 women aged 30-49 years scheduled for invitation to organised screening were randomised in two groups, one to perform self-sampling of VF for HPV test (n=17 997, HPV arm) and the other group to perform screening by PAP smear cytology (n=18 393, control arm)...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29430635/hpv-testing-vs-hpv-cytology-co-testing-to-predict-the-outcome-after-conization
#4
Laerke Valsøe Bruhn, Sisse Josephine Andersen, Jalil Hariri
INTRODUCTION: The purpose of this study was to determine the feasibility of human papillomavirus (HPV) testing alone as prognostic tool to predict recurrent disease within a three years follow-up period after treatment for cervical intraepithelial neoplasia (CIN)2+. MATERIAL AND METHODS: Retrospectively 128 women, with histologically verified CIN2+, who had a conization performed at Southern Jutland Hospital in Denmark between January 1st 2013 and December 31st 2013 were included...
February 11, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29426344/implementation-strategies-to-improve-cervical-cancer-prevention-in-sub-saharan-africa-a-systematic-review
#5
REVIEW
Lauren G Johnson, Allison Armstrong, Caroline M Joyce, Anne M Teitelman, Alison M Buttenheim
BACKGROUND: Developed countries, such as the USA, have achieved significant decreases in cervical cancer burden since the introduction of Pap smear-based programs in the 1960s. Due to implementation barriers and limited resources, many countries in sub-Saharan Africa (SSA) have been unable to attain such reductions. The purpose of this review is to evaluate implementation strategies used to improve the uptake and sustainability of cervical cancer prevention programs in SSA. METHODS: A reviewer (LJ) independently searched PubMed, Ovid/MEDLINE, Scopus, and Web of Science databases for relevant articles with the following search limits: English language, peer reviewed, and published between 1996 and 2017...
February 9, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29422016/malignancy-during-pregnancy-in-japan-an-exceptional-opportunity-for-early-diagnosis
#6
Masayuki Sekine, Yoshiyuki Kobayashi, Tsutomu Tabata, Tamotsu Sudo, Ryuichiro Nishimura, Koji Matsuo, Brendan H Grubbs, Takayuki Enomoto, Tomoaki Ikeda
BACKGROUND: Malignancy during pregnancy has become a significant cause of maternal death in developed countries, likely due to both an older pregnant population, and increases of cervical cancer in younger women. Our aim is to investigate the clinical aspects of malignancy during pregnancy in Japan and to use this information to identify opportunities for earlier detection and treatment. METHODS: We provided a questionnaire to 1508 secondary or tertiary care hospitals in Japan...
February 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29416840/educational-intervention-on-knowledge-of-cervical-cancer-and-uptake-of-pap-smear-test-among-market-women-in-niger-state-nigeria
#7
Godwin Jiya Gana, Mansur O Oche, Jessica Timane Ango, Aminu Umar Kaoje, Kehinde Joseph Awosan, Ismail A Raji
Cervical cancer is the most common female genital tract carcinoma worldwide. It is increasingly becoming the leading carcinoma seen among women in the developing world. The aim of our study was to showcase the effect of educational intervention on the knowledge of cervical cancer and subsequently the uptake of Pap smear test amongst market women in Niger state, Nigeria. The state has a rich network of markets in all the local government areas because of the fishing activities, bountiful agricultural produce yearly and its situation to the North of the national capital, Abuja...
December 31, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/29416214/prevalence-of-specific-types-of-human-papiloma-virus-in-cervical-intraepithelial-lesions-and-cervical-cancer-in-macedonian-women
#8
Irena Aleksioska-Papestiev, Vesna Chibisheva, Megi Micevska, Goran Dimitrov
Introduction: Cervical cancer is a malignancy originating in the transformation zone of the cervix, most commonly in the squamous cells. It is the fourth most common cancer in women worldwide, and the third most common cause of female cancer death. Genital human papilloma viruses (HPV) are sexually transmitted and approximately 630 milion people worldwide are infected. More than 200 genotypes, subtypes and variants have been reported, 13-15 being oncogenic type, which could be responsible for cervical intraepithelial lesions (CIN) or cancer...
February 2018: Medical Archives
https://www.readbyqxmd.com/read/29408192/sociodemographic-and-lifestyle-determinants-of-non-attendance-for-cervical-cancer-screening-in-lithuania-2006-2014
#9
J Petkeviciene, R Ivanauskiene, J Klumbiene
OBJECTIVES: In 2004, Lithuania started the Nationwide Cervical Cancer Screening Programme. The aim of the study was to estimate the trend in the uptake of cervical cancer (CC) screening in Lithuania during 2006-2014 and to identify sociodemographic and lifestyle factors associated with non-attendance for screening. STUDY DESIGN: Cross-sectional studies. METHODS: The data of 4248 women aged 25-60 years who participated in population-based cross-sectional surveys of Lithuanian Health Behaviour Monitoring were analysed...
January 29, 2018: Public Health
https://www.readbyqxmd.com/read/29406336/swedish-women-s-awareness-of-human-papillomavirus-and-health-related-quality-of-life-anxiety-and-depression-after-a-notification-of-an-abnormal-pap-smear-result-a-cross-sectional-study
#10
Marie Rask, Katarina Swahnberg, Marie Oscarsson
This study aims to assess (a) women's awareness of the human papillomavirus (HPV), (b) women's health-related quality of life (HRQoL) and levels of anxiety and depression symptoms, and (c) to compare the outcomes between women who are aware of the sexually transmitted nature of the HPV infection and women who are not. Swedish women who have been notified of an abnormal Pap smear result completed a questionnaire. This questionnaire consisted of sociodemographic characteristics, items on awareness of HPV, and how to cope with the Pap smear result and the instruments: the Functional Assessment of Chronic Illness Therapy - Cervical Dysplasia and the Hospital Anxiety and Depression Scale (HADS)...
February 5, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29403170/comparative-assessment-of-conventional-papanicolaou-and-modified-ultrafast-papanicolaou-stains-in-fine-needle-aspiration-samples-and-body-fluids
#11
P Arul, S Eniya, Magesh Pushparaj, Suresh Masilamani, P Kanmani, C Lingasamy
Background: Conventional Papanicolaou (Pap) stain has undergone many modifications; of these, ultrafast Pap stain is the most popular as it shortens the turnaround time of reporting. Application of modified ultrafast Pap (MUFP) stain in the evaluation of fine needle aspiration (FNA) samples and body fluids are scanty. Aim: To evaluate the utility of MUFP stain in various FNA samples and body fluids and compare the findings with those of conventional Pap stain. Materials and Methods: In this cross-sectional study, two wet-fixed and two airdried smears from each sample [301 samples (255 FNA samples and 46 body fluids)] were prepared and stained by the conventional Pap and MUFP stains, respectively...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29403163/toluidine-blue-with-a-synergistic-effect-in-morphological-assessment-of-oral-cytosmears
#12
T V N Ratna Kumari, B R Ahmed Mujib
Objectives: One percent toluidine blue being the most effective adjunct is often used to detect dysplasia. Not much attention has been given to the effect of toluidine blue in enhancement of cytological smears. The present study assessed the smears before and after application of toluidine blue in smokers against non-smokers using three different stains [Papanicolaou (PAP), Hematoxylin and Eosin (H and E), and Giemsa]. Study Design: Twenty-five individuals from each group participated in the study...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29390909/colpocytological-abnormalities-in-hiv-infected-and-uninfected-pregnant-women-prevalence-persistence-and-progression
#13
Carmine Carriero, Fabiana Divina Fascilla, Paola Cramarossa, Achiropita Lepera, Stefano Bettocchi, Antonella Vimercati
In this retrospective case-control study, we analyse data of 48 HIV-positive pregnant patients, versus a control group of 99 HIV-negative pregnant women, followed as outpatients by our department from 2009 to 2014. The aims of the study were to investigate the prevalence, persistence and progression of cervical squamous intraepithelial lesions (SIL) in each group and to correlate colpo-cytological lesions to the socio-demographic and clinical-laboratory findings in the HIV + pregnant women. In our study we observed that immunosuppression, HPV infection and vaginal coinfections were predictive of cervical lesions...
February 1, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29385850/human-papilloma-virus-hpv-self-sampling-do-women-accept-it
#14
Nik Nairan Abdullah, Suzanna Daud, Seok Mui Wang, Zamalia Mahmud, Noor Kaslina Mohd Kornain, Waqar Al-Kubaisy
This study aims to determine the acceptability of Human Papilloma Virus (HPV) self-sampling and the factors associated with willingness to buy HPV self-sampling kit in the future. A total of 164 women aged 28-60 years old from Obstetrics & Gynaecology clinics at a teaching hospital performed HPV self-sampling using the Digene HC2 DNA collection kit. After samples were taken, the participants were given self-administered questionnaires. The majority of the participants were Malay (93.9%), had attained tertiary education (65...
January 31, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29382323/prevalence-of-high-risk-hpv-genotypes-categorised-by-their-quadrivalent-and-nine-valent-hpv-vaccination-coverage-and-the-genotype-association-with-high-grade-lesions
#15
María Paz-Zulueta, Ledicia Álvarez-Paredes, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Ma Encarnación Andrada Becerra, José María Rodríguez Ingelmo, María Montserrat Ruiz García, Joaquín Portilla, Miguel Santibañez
BACKGROUND: The new nine-valent vaccine against human papillomavirus (HPV) includes the four HPV genotypes (6, 11, 16, and 18) that are targeted by the older quadrivalent HPV vaccine, plus five additional oncogenic types (31, 33, 45, 52, and 58) remain significantly associated with high grade lesions. We aimed to determine the prevalence of high-risk HPV genotypes in unvaccinated subjects and the association of these genotypes with the incidence of high-grade lesions. We also assessed which, if either, of these two HPV vaccines could have prevented these cases...
January 30, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29374678/multiple-types-of-human-papillomavirus-infection-and-anal-precancerous-lesions-in-hiv-infected-men-in-taiwan-a-cross-sectional-study
#16
Shu-Hsing Cheng, Kuo-Sheng Liao, Chi-Chao Wang, Chien-Yu Cheng, Fang-Yeh Chu
OBJECTIVES: This study aimed to assess the relationship between infection with multiple human papillomavirus (HPV) types and abnormal anal cytology in HIV-infected men. DESIGN: An observational, cross-sectional study. SETTING: A regional referral hospital in Taiwan. PARTICIPANTS: In total, 714 HIV-infected men were enrolled between March 2011 and June 2016. Thin preparation anal Pap smears were interpreted according to the 2001 Bethesda System...
January 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29373905/significance-of-dna-replication-licensing-proteins-mcm2-mcm5-and-cdc6-p16-and-p63-as-markers-of-premalignant-lesions-of-the-uterine-cervix-its-usefulness-to-predict-malignant-potential
#17
V N Saritha, V S Veena, K M Jagathnath Krishna, Thara Somanathan, K Sujathan
Cervical cancer continues to be a leading cancer among women in many parts of the world. Nation-wide screening with the Pap smear has not been implemented in India due to the lack of adequately trained cytologists. Identification of biomarkers to predict malignant potential of the identified low risk lesions is essential to avoid excessive retesting and follow up. The current study analyzed the expression patterns of DNA replication licensing proteins, proliferation inhibitor protein p16INK4A and tumor suppresser protein p63 in cervical tissues and smears to assess the ability of these proteins to predict progression...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29373882/the-association-between-bisphenol-a-and-polycystic-ovarian-syndrome-a-case-control-study
#18
Batool Hossein Rashidi, Massoud Amanlou, Tahere Behrouzi Lak, Mahya Ghazizadeh, Fedyeh Haghollahi, Maryam Bagheri, Bita Eslami
Polycystic ovarian syndrome (PCOS) is an endocrine metabolic disorder with unclear etiopathogenesis among reproductive age women. Evidences show genetic susceptibility and environmental factors were associated with PCOS. The aim of this study was to find the association between urinary concentrations of Bisphenol-A as an endocrine disrupting chemical (EDC) and PCOS. A case-control study was conducted in 51 samples in each group. All cases were selected from women who diagnosed with PCOS at Gynecology and infertility center...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29366369/social-and-cultural-barriers-to-women-s-participation-in-pap-smear-screening-programs-in-low-and-middle-income-latin-american-and-caribbean-countries-an-integrative-review
#19
Erica J Liebermann, Nancy VanDevanter, Marilyn J Hammer, Mei R Fu
PURPOSE: Pap smear screening programs have been ineffective in reducing cervical cancer mortality in most Latin American and Caribbean countries, in part due to low screening rates. The purpose of this review was to analyze recent studies to identify demographic, social, and cultural factors influencing women's participation in Pap screening programs in Latin America and the Caribbean. DESIGN/METHOD: For this integrative review, cervical cancer screening in Latin America and the Caribbean was searched using PubMed, CINAHL, EMBASE, and PsycINFO databases...
January 1, 2018: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/29346698/procedural-knowledge-and-skills-of-residents-entering-canadian-family-medicine-programs-in-alberta
#20
Juan Antonio Garcia-Rodriguez, James A Dickinson, Grace Perez, David Ross, Lilian Au, Shelley Ross, Oksana Babenko, Ian Johnston
BACKGROUND AND OBJECTIVES: Incoming family medicine (FM) residents start residency with different levels of procedural training. Understanding their baseline skill level is necessary to plan the educational experiences and teaching methods that will provide the desired knowledge, skills, and attitudes related to performing medical procedures. METHODS: A survey of 69 procedures based on the core list issued by the College of Family Physicians of Canada was administered to incoming residents in Alberta (Calgary and Edmonton FM programs)...
January 2018: Family Medicine
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