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https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#1
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29201366/survey-on-the-availability-price-and-affordability-of-selected-essential-medicines-for-non-communicable-diseases-in-community-pharmacies-of-kathmandu-valley
#2
Rajeev Shrestha, Anish Ghale, Bijay Raj Chapagain, Mahasagar Gyawali, Trishna Acharya
Background: The access to essential medicines for non-communicable disease treatment is unacceptably low worldwide. The fundamental right to health cannot be fulfilled without equitable access to essential medicines. Methodology: A cross-sectional study was carried out in 94 community pharmacies of Kathmandu valley. Non-probability quota sampling method was adopted for the purpose. Village Development Committees with more than 5000 populations were included in the study...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29169785/-parental-alienation-child-psychological-abuse-and-dsm-5
#3
P Bensussan
Psychiatric experts find it is easier to deal with more horrible crimes than highly conflictual divorces. In the former, projections are impossible and "files" raise very interesting issues with regard to criminology; in contrast, in the latter the expert is confronted not just with a family but also and lest one forget, a couple that at one point in time had loved each other. However, the separation resembles a bloodbath. We will not detail the various psychiatric pathologies, which may further complicate a separation: they are well-known and, on a procedural level, do not raise any specific concerns...
November 20, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29136341/photodynamic-therapy-and-nuclear-imaging-activities-of-zinc-phthalocyanine-integrated-tio2-nanoparticles-in-breast-and-cervical-tumors
#4
Fatma Yurt, Kasim Ocakoglu, Mine Ince, Suleyman Gokhan Colak, Ozge Er, Hale Melis Soylu, Cumhur Gunduz, Cıgır Biray Avci, Cansu Caliskan Kurt
In recent years, phthalocyanines (Pcs) have been widely used as photosensitizer in photodynamic therapy applications. Because of their strong absorptions in the near-infrared region (640-700 nm). The integration of phthalocyanine derivatives to a nanoparticle is expected to be efficient way to improve the activity of the photosensitizer on the targeted tissue. It is known that the integrated molecules not only show better accumulation on tumor tissue but also reduce toxicity in healthy tissues. In this study, the ZnPc molecule was synthesized and integrated to the TiO2 nanoparticle, to investigate the potential of PDT and its cytotoxicity...
November 14, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29131343/extracting-wair-from-the-electron-beam-measurements-of-domen-and-lamperti
#5
Frédéric Tessier, Claudiu Dorin Cojocaru, Carl Kenneth Ross
PURPOSE: The average energy expended by an energetic electron to create an ion pair in dry air, Wair, is a key quantity in radiation dosimetry. Although Wair is well established for electron energies up to about 3 MeV there is limited data for higher energies. The measurements by Domen and Lamperti [Med. Phys. 3, 294{301 (1976)] using electron beams in the energy range from 15 to 50 MeV can, in principle, be used to deduce values for Wair, if the electron stopping power of graphite and air are known...
November 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29123024/the-convention-on-the-rights-of-persons-with-disabilities-as-a-tobacco-control-tool-in-the-mental-health-setting
#6
Yvette van der Eijk
BACKGROUND: Smoking rates remain high among people with mental health conditions, even though smoking contributes to negative mental health outcomes and is a leading cause of mortality. Many mental health facilities are not covered by smoke-free laws or do not encourage smoking cessation, and people with mental health conditions are often targeted in tobacco industry promotions. OBJECTIVE: To analyse how the Convention on the Rights of Persons with Disabilities (CRPD), to which most countries are a Party, obliges State Parties to review policies and practices for tobacco control in the mental health setting...
November 9, 2017: Tobacco Control
https://www.readbyqxmd.com/read/29117465/more-sprint-controversy
#7
Franz H Messerli, Sripal Bangalore, Stefano F Rimoldi
Frohlich and Zanchetti, at that time editors-in-chief of Hypertension and Journal of Hypertension, wrote the above words 20 years ago, in midst of the so-called calcium blocker controversy in a dual publication [3]. The authors continued in stating "however, controversy should be based on sound scientific evidence". One may ask whether this indeed is not a contradiction in terms as how can sound scientific evidence possibly give rise to controversy? The answer to this question is quite simple: science may be perfectly sound but interpretation thereof very often is anything but...
November 8, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29114335/imaging-of-the-unstable-shoulder
#8
Paolo Baudi, Manuela Rebuzzi, Giovanni Matino, Fabio Catani
Background: Unstable shoulder can occur in different clinical scenarios with a broad spectrum of symptoms and presentations: first-time (or recurrent) traumatic acute shoulder anterior dislocation or chronic anterior instability after repeated dislocations.Imaging in unstable shoulder is fundamental for choosing the right treatment preventing recurrence.The goal of imaging depends on clinical scenario and patient characteristics. Method: Careful selection and evaluation of the imaging procedures is therefore essential to identify, characterize and quantify the lesions...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29065208/advice-from-former-smoking-e-cigarette-users-to-current-smokers-on-how-to-use-e-cigarettes-as-part-of-an-attempt-to-quit-smoking
#9
Christopher Russell, Tiffany Dickson, Neil McKeganey
Introduction: Substitution of e-cigarettes for tobacco smoking has the potential to prevent almost all the harm caused by smoking. Identifying strategies that may increase smokers' capability, opportunity and motivation to use e-cigarettes in place of tobacco cigarettes is vital. Former smokers who have successfully used e-cigarettes to quit smoking may be especially well qualified to increase current smokers' interest in switching and ability to switch to e-cigarettes. Methods: A multi-national, self-selected sample of 4192 former smokers who quit smoking by using e-cigarettes were asked, via an online survey, the advice they would offer to smokers who are considering using e-cigarettes to support an attempt to quit smoking...
August 3, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29052847/effects-of-oil-content-on-the-sensory-textural-and-physical-properties-of-pecan-butter-carya-illinoinensis
#10
Emily A Wagener, William L Kerr
It has been difficult to produce acceptable pecan butters as the high oil content results in a product that flows and separates too easily. The objective of this work was to create pecan butters with varying oil levels (50-70%) and determine which would give the most acceptable product. Consumers rated pecan butters with 55-60% oil the most acceptable, whether roasted or not. Acceptability varied most in terms of texture and spreadability, but not flavor. Under large deformation firmness varied from 51.8 g (70% oil) to 4880 g (50%) oil, while 'spreadability' ranged from 19...
October 20, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/29052334/partner-smoking-influences-whether-mothers-quit-smoking-during-pregnancy-a-prospective-cohort-study
#11
R M Román-Gálvez, C Amezcua-Prieto, R Olmedo-Requena, A M Lewis-Mikhael Saad, J M Martínez-Galiano, A Bueno-Cavanillas
OBJECTIVE: To analyze the prevalence and intensity of smoking among pregnant women and their partners and factors associated with quitting smoking among pregnant women. DESIGN: A prospective cohort study starting in 2013. SETTING: Andalusia, the south of Spain. SAMPLE: 486 healthy pregnant women followed up on three occasions during pregnancy. METHODS: Estimation of the proportions of women and partners who quit smoking at each trimester...
October 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29024132/expression-of-isotocin-is-male-specifically-upregulated-by-gonadal-androgen-in-the-medaka-brain
#12
Junpei Yamashita, Yukika Kawabata, Kataaki Okubo
Oxytocin, a mammalian neuropeptide primarily synthesized in the supraoptic and paraventricular nuclei of the hypothalamus, mediates a variety of physiological and behavioral processes ranging from parturition and lactation to affiliation and prosociality. Multiple studies in rodents have shown that the expression of the oxytocin gene (Oxt) is stimulated by estrogen, while androgen has no apparent effect. However, this finding is not consistent across all studies, and no study has examined sex steroid regulation of Oxt or its orthologs in other animals...
October 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28945313/severe-infantile-isolated-exocrine-pancreatic-insufficiency-caused-by-the-complete-functional-loss-of-the-spink1-gene
#13
Théa Venet, Emmanuelle Masson, Cécile Talbotec, Kareen Billiemaz, Renaud Touraine, Claire Gay, Sylvie Destombe, David N Cooper, Hugues Patural, Jian-Min Chen, Claude Férec
Exocrine pancreatic insufficiency (EPI) is rare in children, with most if not all cases occurring as part of syndromic conditions such as cystic fibrosis and Shwachman-Diamond syndrome. Here we report two cases, both presenting with severe EPI around 5 months of age. Characterized by diffuse pancreatic lipomatosis, they otherwise exhibited no remarkable deficiencies in other organs. Novel non-identical homozygous variants (a deletion removing the entire SPINK1 gene and an insertion of a full-length inverted Alu element into the 3'-untranslated region of the SPINK1 gene) resulting in the complete functional loss of the SPINK1 gene (encoding pancreatic secretory trypsin inhibitor) were identified in each patient...
September 25, 2017: Human Mutation
https://www.readbyqxmd.com/read/28918649/characterizing-verified-head-impacts-in-high-school-girls-lacrosse
#14
Shane V Caswell, Andrew E Lincoln, Hannah Stone, Patricia Kelshaw, Margot Putukian, Lisa Hepburn, Michael Higgins, Nelson Cortes
BACKGROUND: Girls' high school lacrosse players have higher rates of head and facial injuries than boys. Research indicates that these injuries are caused by stick, player, and ball contacts. Yet, no studies have characterized head impacts in girls' high school lacrosse. PURPOSE: To characterize girls' high school lacrosse game-related impacts by frequency, magnitude, mechanism, player position, and game situation. STUDY DESIGN: Descriptive epidemiology study...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28911338/organisational-culture-and-trust-as-influences-over-the-implementation-of-equity-oriented-policy-in-two-south-african-case-study-hospitals
#15
Ermin Erasmus, Lucy Gilson, Veloshnee Govender, Moremi Nkosi
BACKGROUND: This paper uses the concepts of organisational culture and organisational trust to explore the implementation of equity-oriented policies - the Uniform Patient Fee Schedule (UPFS) and Patients' Rights Charter (PRC) - in two South African district hospitals. It contributes to the small literatures on organisational culture and trust in low- and middle-income country health systems, and broader work on health systems' people-centeredness and "software". METHODS: The research entailed semi-structured interviews (Hospital A n = 115, Hospital B n = 80) with provincial, regional, district and hospital managers, as well as clinical and non-clinical hospital staff, hospital board members, and patients; observations of policy implementation, organisational functioning, staff interactions and patient-provider interactions; and structured surveys operationalising the Competing Values Framework for measuring organisational culture (Hospital A n = 155, Hospital B n = 77) and Organisational Trust Inventory (Hospital A n = 185, Hospital B n = 92) for assessing staff-manager trust...
September 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28887832/extracellular-vesicles-from-oral-squamous-carcinoma-cells-display-pro-and-antiangiogenic-properties
#16
Ana Luiza Dias Leite de Andrade, Carine Ervolino de Oliveira, Maurício Rocha Dourado, Carolina Carneiro Soares Macedo, Flávia Vischi Winck, Adriana Franco Paes Leme, Tuula Salo, Ricardo D Coletta, Roseana de AlmeidaFreitas, Hébel Cavalcanti Galvão
BACKGROUND: A new intercellular communication mode established by neoplastic cells and tumor microenvironment components is based on extracellular vesicles (EVs). However, the biological effects of the EVs released by tumor cells on angiogenesis are not completed understood. Here we aimed to understand the biological effects of EVs isolated from two cell lines of oral squamous cell carcinoma (OSCC) (SCC15 and HSC3) on endothelial cell tubulogenesis. METHODS: OSCC-derived EVs were isolated with a polymer-based precipitation method, quantified using nanoparticle tracking analysis and verified for EV markers by dot-blot...
September 8, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28884828/neutrophil-extracellular-traps-in-acrolein-promoted-hepatic-ischemia-reperfusion-injury-therapeutic-potential-of-nox2-and-p38mapk-inhibitors
#17
Arumugam Suyavaran, Kesthuru Subbiah Girish, K Kemparaju, Chinnasamy Thirunavukkarasu
Neutrophil is a significant contributor to ischemia reperfusion (IR) induced liver tissue damage. However, the underlying mechanisms of IR induced innate immune activation and liver damage is not quite clear. Our study sheds light on the role of chronic oxidative stress end products in worsening the IR inflammatory process by neutrophil recruitment and activation following liver surgery. We employed specific inhibitors for molecular targets - NOX2 (NADPH oxidase 2) and P38 MAPK (Mitogen activated protein kinase) signal to counteract neutrophil activation and neutrophil extracellular trap (NET) release induced liver damage in IR injury...
September 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28874271/in-pursuit-of-our-ancestors-hand-laterality
#18
Amèlia Bargalló, Marina Mosquera, Sergi Lozano
The aim of this paper is to apply a previously published method (Bargalló and Mosquera, 2014) to the archaeological record, allowing us to identify the hand laterality of our ancestors and determine when and how this feature, which is exhibited most strongly in humans, appeared in our evolutionary history. The method focuses on identifying handedness by looking at the technical features of the flakes produced by a single knapper, and discovering how many flakes are required to ascertain their hand preference...
October 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28856586/tio2-nanowired-delivery-of-dl-3-n-butylphthalide-dl-nbp-attenuates-blood-brain-barrier-disruption-brain-edema-formation-and-neuronal-damages-following-concussive-head-injury
#19
Lianyuan Feng, Aruna Sharma, Feng Niu, Yin Huang, José Vicente Lafuente, Dafin Fior Muresanu, Asya Ozkizilcik, Z Ryan Tian, Hari Shanker Sharma
DL-3-n-butylphthalide (DL-NBP) is one of the constituents of Chinese celery extract that is used to treat stroke, dementia, and ischemic diseases. However, its role in traumatic brain injury is less well known. In this investigation, neuroprotective effects of DL-NBP in concussive head injury (CHI) on brain pathology were explored in a rat model. CHI was inflicted in anesthetized rats by dropping a weight of 114.6 g from a height of 20 cm through a guide tube on the exposed right parietal bone inducing an impact of 0...
August 30, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28810158/a-typology-of-vaping-identifying-differing-beliefs-motivations-for-use-identity-and-political-interest-amongst-e-cigarette-users
#20
Hannah Farrimond
BACKGROUND: The aim of this study was to identify and differentiate socially shared accounts of e-cigarette use (vaping) using Q-methodology, combining factor analysis with qualitative comments. METHODS: Seventy statements on e-cigarettes, drawn from media, academic and online discussions, were sorted by participants along a continuum of agreement/disagreement, commenting on strongly ranked items. Each participant thus created their own 'account' of their vaping...
October 2017: International Journal on Drug Policy
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