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https://www.readbyqxmd.com/read/29614284/animal-left-right-asymmetry
#1
Martin Blum, Tim Ott
Symmetry is appealing, be it in architecture, art or facial expression, where symmetry is a key feature to finding someone attractive or not. Yet, asymmetries are widespread in nature, not as an erroneous deviation from the norm but as a way to adapt to the prevailing environmental conditions at a time. Asymmetries in many cases are actively selected for: they might well have increased the evolutionary fitness of a species. Even many single-celled organisms are built asymmetrically, such as the pear-shaped ciliate Paramecium, which may depend on its asymmetry to navigate towards the oxygen-richer surface of turbid waters, at least based on modeling...
April 2, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29611154/intracorporeal-ileocolic-anastomosis-in-laparoscopic-right-colectomy-a-new-way-to-make-it-simple
#2
Roberto Rossini, Giorgio Lisi, Irene Gentile, Giuliano Barugola, Giacomo Ruffo
Although there has been a recent increase in the use of laparoscopy in colorectal surgery, the percentage of patients who undergo surgery using entirely minimally invasive techniques is still quite low, and there are substantial differences among centers. It has been argued that the limiting factor in the use of laparoscopic procedures is not the tumor or patient characteristics, but rather the number of surgeons with adequate skills to perform an entirely laparoscopic colectomy. To address this issue, we report here our totally laparoscopic right colectomy technique, with particular focus on a new way to perform the enterotomy closure, which may simplify ileocolic anastomosis...
March 29, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29578572/physiological-characterization-and-quantitative-proteomic-analyses-of-metabolically-engineered-e-coli-k4-strains-with-improved-pathways-for-capsular-polysaccharide-biosynthesis
#3
Donatella Cimini, Rosita Russo, Sergio D'Ambrosio, Ileana Dello Iacono, Camilla Rega, Elisabetta Carlino, Ottavia Argenzio, Luigi Russo, Brigida D'Abrosca, Angela Chambery, Chiara Schiraldi
Among capsulated bacteria, some produce polysaccharides with unique properties that have been shown to possess relevant industrial applications and commercial value. The capsular polysaccharide (CPS) produced by E.coli K4 is similar to chondroitin sulphate, and recent efforts focused on the development of genetic and fermentation strategies to increase its production titers up to technologically attractive levels. However, the control of the metabolic pathways leading to CPS synthesis together with the effect of varying the concentration of pathway intermediates on CPS final titers, is still quite unexplored and not fully understood...
March 26, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29575715/waste
#4
EDITORIAL
Pontus B Persson, Anja B Persson
Is waste essentially a man-made concept? Before the dawn of humanity, it would, in all probability, have been safe to claim that nature does not do waste. Perfect recycling, it seems, ensured a balance of raw materials and energy expenditure among living beings and their natural habitats on the surface of the apparently rare exception in our universe, that of a living planet. Until, only quite recently, man, by means of an exceptional development of neocortical structure and function, stepped out of the shadows...
March 25, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29573440/do-electronic-cigarettes-have-a-role-in-tobacco-cessation
#5
Andrea S Franks, Karen Sando, Sarah McBane
Tobacco use continues to be a major cause of morbidity and mortality. Even with behavioral and pharmacologic treatment, long-term tobacco cessation rates are low. Electronic nicotine delivery systems, commonly referred to as electronic cigarettes or e-cigarettes, are increasingly used for tobacco cessation. Because e-cigarettes are widely used in this setting, health care professionals need to know if they are safe and effective. The purpose of this article is to review literature regarding use of e-cigarettes as a tool for tobacco cessation in patients who are ready to quit, as well as those who are not ready to quit, along with some selected patient populations...
March 24, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29571063/advantage-of-laparoscopic-resection-for-pelvic-schwannoma-case-report-and-review-of-the-literature
#6
Marino Di Furia, Andrea Salvatorelli, Andrea Della Penna, Vincenzo Vicentini, Federico Sista, Alessandro Chiominto, Stefano Guadagni, Marco Clementi
INTRODUCTION: Single pelvic schwannomas are rare tumor arising from the retrorectal, lateral or obturatory space. Laparoscopic approach to schwannoma located in lateral pelvic space has been previously described only in one case report. We present a case of a successful laparoscopic resection of pelvic schwannoma emphasizing the advantages of such a minimal invasive approach. PRESENTATION OF CASE: A 54-years-old, obese, male patient was admitted to our hospital referring dysuria and strangury...
March 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29543179/you-spin-my-head-right-round-threshold-of-limited-immersion-for-rotation-gains-in-redirected-walking
#7
Patric Schmitz, Julian Hildebrandt, Andre Calero Valdez, Leif Kobbelt, Martina Ziefle
In virtual environments, the space that can be explored by real walking is limited by the size of the tracked area. To enable unimpeded walking through large virtual spaces in small real-world surroundings, redirection techniques are used. These unnoticeably manipulate the user's virtual walking trajectory. It is important to know how strongly such techniques can be applied without the user noticing the manipulation-or getting cybersick. Previously, this was estimated by measuring a detection threshold (DT) in highly-controlled psychophysical studies, which experimentally isolate the effect but do not aim for perceived immersion in the context of VR applications...
April 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29533239/model-validation-local-diagnosis-correction-and-when-to-quit
#8
Jane S Richardson, Christopher J Williams, Bradley J Hintze, Vincent B Chen, Michael G Prisant, Lizbeth L Videau, David C Richardson
Traditionally, validation was considered to be a final gatekeeping function, but refinement is smoother and results are better if model validation actively guides corrections throughout structure solution. This shifts emphasis from global to local measures: primarily geometry, conformations and sterics. A fit into the wrong local minimum conformation usually produces outliers in multiple measures. Moving to the right local minimum should be prioritized, rather than small shifts across arbitrary borderlines...
February 1, 2018: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/29512213/the-role-of-the-dermatologist-in-raynaud-s-phenomenon-a-clinical-challenge
#9
REVIEW
Caterina Matucci-Cerinic, Vivek Nagaraja, Francesca Prignano, Bashar Kahaleh, Silvia Bellando-Randone
Raynaud's phenomenon (RP) is a functional vascular disorder involving extremities. In his practice, the dermatologist may frequently encounter RP which affects mainly women and is categorized into a primary benign form and a secondary form associated with different diseases (infections, drugs, autoimmune and vascular conditions, hematologic, rheumatologic and endocrinologic disorders). Still today, the differential diagnosis is a clinical challenge. Therefore, a careful history and a physical examination, together with laboratory tests and nailfold capillaroscopy are mandatory...
March 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29499551/task-activation-and-functional-connectivity-show-concordant-memory-laterality-in-temporal-lobe-epilepsy
#10
Noah Sideman, Ganne Chaitanya, Xiaosong He, Gaelle Doucet, Na Young Kim, Michael R Sperling, Ashwini D Sharan, Joseph I Tracy
OBJECTIVE: In epilepsy, asymmetries in the organization of mesial temporal lobe (MTL) functions help determine the cognitive risk associated with procedures such as anterior temporal lobectomy. Past studies have investigated the change/shift in a visual episodic memory laterality index (LI) in mesial temporal lobe structures through functional magnetic resonance imaging (fMRI) task activations. Here, we examine whether underlying task-related functional connectivity (FC) is concordant with such standard fMRI laterality measures...
February 27, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29498459/mental-health-service-user-and-staff-perspectives-on-tobacco-addiction-and-smoking-cessation-a-meta-synthesis-of-published-qualitative-studies
#11
REVIEW
Victoria Malone, Roger Harrison, Gavin Daker-White
INTRODUCTION: People with mental illness are up to 3 times more likely to smoke and experience greater challenges and less success when trying to quit, therefore have higher risk of smoking-related morbidity and mortality. There is a lack of evidence on successful interventions to reduce the smoking rates in people living with serve mental illness. A meta-synthesis was undertaken to summarise data from multiple studies to inform the development of future smoking cessation intervention studies...
March 2, 2018: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29489341/the-chemistry-of-inorganic-precursors-during-the-chemical-deposition-of-films-on-solid-surfaces
#12
Seán T Barry, Andrew V Teplyakov, Francisco Zaera
The deposition of thin solid films is central to many industrial applications, and chemical vapor deposition (CVD) methods are particularly useful for this task. For one, the isotropic nature of the adsorption of chemical species affords even coverages on surfaces with rough topographies, an increasingly common requirement in microelectronics. Furthermore, by splitting the overall film-depositing reactions into two or more complementary and self-limiting steps, as it is done in atomic layer depositions (ALD), film thicknesses can be controlled down to the sub-monolayer level...
February 28, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29479957/neuroendocrine-tumors-detected-in-appendectomy-specimens-ten-year-single-center-experience
#13
Fatma Şenel, Hatice Karaman, Hacer Demir
Background/aim: The aim of this study was to investigate neuroendocrine tumors (NETs) detected in appendectomy specimens and the incidence and clinicopathologic characteristics of these tumors in our center. Materials and methods: A total of 13,863 patients were evaluated retrospectively. All underwent appendectomy operation in the Kayseri Training and Research Hospital and had a histopathological examination at the Pathology Clinic between January 2007 and March 2017. Age, sex, preoperative clinical findings, operation procedure, and histopathological examination results of the cases reported to be NET are presented...
February 23, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29475170/a-case-report-of-anterior-cruciate-ligament-and-posterolateral-corner-reconstruction-using-tendon-graft-preserved-in-situ
#14
Bosco Mpatswenumugabo, Emmanuel Bukara, Muhammed Semakula, Albert Nzayisenga, Rene Mukezamfura, Lambert Dusingizimana, Basile Habumugisha, Salvador Kamarampaka, Leon Mutesa, Alex Butera
INTRODUCTION: Combined anterior cruciate ligament (ACL) and posterolateral corner (PLC) reconstruction are a rare clinical entity in orthopedic literature, whose management requires different types of tendon grafts. Missed PLC injury leads to the failure of ACL repair due to the joint instability. PRESENTATION OF CASE: We are presenting a case of posttraumatic right ACL, PLC and lateral meniscus injury. The patient was taken to theatre for arthroscopic meniscectomy, ACL and PLC reconstruction...
February 17, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29464410/simulations-of-microscopic-propulsion-of-soft-elastic-bodies
#15
David Urbanik, Shikhar Mani Dwivedi, Colin Denniston
Using simulations that realistically model both hydrodynamic and elastic behavior, we study the motion of a microscopic, driven elastic sphere immersed in water. We first confirm the "jittery" relaxation recently predicted theoretically for an externally driven elastic sphere. The sphere is then divided in two and each section is driven internally with the two sections 180° out of phase. With periodic and perfectly symmetric driving, the elastic sphere spontaneously breaks symmetry and can attain macroscopic average swimming velocities to the right or left, the direction depending only on the initial state...
February 16, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29457222/extreme-dentition-does-not-prevent-diet-and-tooth-diversification-within-combtooth-blennies-ovalentaria-blenniidae
#16
Peter J Hundt, Andrew M Simons
The dentition of fishes can be quite striking and is often correlated with a specific diet. Combtooth blennies have long incisiform oral teeth, unlike most actinopterygians. It has been suggested that the long tooth morphology is an adaptation for detritivory, but given the diversity of diets (detritus, coral polyps, polychaetes, and pieces of other fishes), are blenny teeth indeed monomorphic? Or does tooth variation associated with diet still exist at this extreme? To explore tooth and diet diversification, we used a new phylogenetic hypothesis of Blenniidae, measured tooth shape, number, and mode of attachment, and quantified blenniid diet...
February 18, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29451338/can-dimedone-be-used-to-study-selenoproteins-an-investigation-into-the-reactivity-of-dimedone-towards-oxidized-forms-of-selenocysteine
#17
N Connor Payne, Drew R Barber, Erik L Ruggles, Robert J Hondal
Dimedone is a widely used reagent to assess the redox state of cysteine-containing proteins as it will alkylate sulfenic acid residues, but not sulfinic acid residues. While it has been reported that dimedone can label selenenic acid residues in selenoproteins, we investigated the stability, and reversibility of this label in a model peptide system. We also wondered whether dimedone could be used to detect seleninic acid residues. We used benzenesulfinic acid, benzeneseleninic acid, and model selenocysteine-containing peptides to investigate possible reactions with dimedone...
February 16, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29443453/alternative-pre-mrna-splicing
#18
Valentin Schmidt, Karin M Kirschner
Have you ever felt ashamed of yourself when using copy and paste instead of writing an original? You do not have to! Nature is using copy and paste with incredibly great success and we can learn a lot by studying this intriguing method called alternative splicing.If you compare the mRNA with genomic sequences, you will notice that they are quite different. This article is protected by copyright. All rights reserved.
February 14, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29441039/metastatic-burned-out-seminoma-causing-neurological-paraneoplastic-syndrome-not-quite-burned-out
#19
Yuval Freifeld, Payal Kapur, Ritika Chitkara, Francesca Lee, Pravin Khemani, Aditya Bagrodia
A 44-year-old man presented with cerebellar ataxia and limbic encephalitis and was ultimately diagnosed with metastatic germ cell neoplasm resulting from a "burned out" primary testicular tumor. The patient had progressive ataxia, leading to a thorough investigation for infectious, autoimmune, metabolic, and malignant causes of acquired cerebellar ataxia that revealed no significant findings. Testicular sonography demonstrated a possible right testicular lesion that was not confirmed on radical inguinal orchiectomy...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29383707/is-tweak-a-valid-screening-questionnaire-to-identify-alcohol-risk-drinkers-among-pregnant-women-in-denmark
#20
Camilla Praestegaard, Pia Schiøler Kesmodel, Ulrik Schiøler Kesmodel
INTRODUCTION: Identification of pregnant alcohol risk drinkers is crucial to prevent adverse birth outcomes. The TWEAK screening instrument has shown promising results for identifying risk drinkers. However, as the effectiveness of the screening questionnaire has only been investigated among American women with mainly low socioeconomic status, we aimed to investigate the ability of TWEAK to identify alcohol risk drinkers among pregnant Danish women. MATERIAL AND METHODS: During 2000, Danish-speaking women referred to the Midwife Centre at Aarhus University Hospital (n = 1554) and Frederica Hospital (n = 499) for routine antenatal care were invited to participate in the study at their first visit...
January 30, 2018: Acta Obstetricia et Gynecologica Scandinavica
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