keyword
MENU ▼
Read by QxMD icon Read
search

not quite right

keyword
https://www.readbyqxmd.com/read/29457222/extreme-dentition-does-not-prevent-diet-and-tooth-diversification-within-combtooth-blennies-ovalentaria-blenniidae
#1
Peter J Hundt, Andrew M Simons
The dentition of fishes can be quite striking and is often correlated with a specific diet. Combtooth blennies have long incisiform oral teeth, unlike most actinopterygians. It has been suggested that the long tooth morphology is an adaptation for detritivory, but given the diversity of diets (detritus, coral polyps, polychaetes, and pieces of other fishes), are blenny teeth indeed monomorphic? Or does tooth variation associated with diet still exist at this extreme? To explore tooth and diet diversification, we used a new phylogenetic hypothesis of Blenniidae, measured tooth shape, number, and mode of attachment, and quantified blenniid diet...
February 18, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29451338/can-dimedone-be-used-to-study-selenoproteins-an-investigation-into-the-reactivity-of-dimedone-towards-oxidized-forms-of-selenocysteine
#2
N Connor Payne, Drew R Barber, Erik L Ruggles, Robert J Hondal
Dimedone is a widely used reagent to assess the redox state of cysteine-containing proteins as it will alkylate sulfenic acid residues, but not sulfinic acid residues. While it has been reported that dimedone can label selenenic acid residues in selenoproteins, we investigated the stability, and reversibility of this label in a model peptide system. We also wondered whether dimedone could be used to detect seleninic acid residues. We used benzenesulfinic acid, benzeneseleninic acid, and model selenocysteine-containing peptides to investigate possible reactions with dimedone...
February 16, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29443453/alternative-pre-mrna-splicing
#3
Valentin Schmidt, Karin M Kirschner
Have you ever felt ashamed of yourself when using copy and paste instead of writing an original? You do not have to! Nature is using copy and paste with incredibly great success and we can learn a lot by studying this intriguing method called alternative splicing.If you compare the mRNA with genomic sequences, you will notice that they are quite different. This article is protected by copyright. All rights reserved.
February 14, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29441039/metastatic-burned-out-seminoma-causing-neurological-paraneoplastic-syndrome-not-quite-burned-out
#4
Yuval Freifeld, Payal Kapur, Ritika Chitkara, Francesca Lee, Pravin Khemani, Aditya Bagrodia
A 44-year-old man presented with cerebellar ataxia and limbic encephalitis and was ultimately diagnosed with metastatic germ cell neoplasm resulting from a "burned out" primary testicular tumor. The patient had progressive ataxia, leading to a thorough investigation for infectious, autoimmune, metabolic, and malignant causes of acquired cerebellar ataxia that revealed no significant findings. Testicular sonography demonstrated a possible right testicular lesion that was not confirmed on radical inguinal orchiectomy...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29383707/is-tweak-a-valid-screening-questionnaire-to-identify-alcohol-risk-drinkers-among-pregnant-women-in-denmark
#5
Camilla Praestegaard, Pia Schiøler Kesmodel, Ulrik Schiøler Kesmodel
INTRODUCTION: Identification of pregnant alcohol risk drinkers is crucial to prevent adverse birth outcomes. The TWEAK screening instrument has shown promising results for identifying risk drinkers. However, as the effectiveness of the screening questionnaire has only been investigated among American women with mainly low socioeconomic status, we aimed to investigate the ability of TWEAK to identify alcohol risk drinkers among pregnant Danish women. MATERIAL AND METHODS: During 2000, Danish-speaking women referred to the Midwife Centre at Aarhus University Hospital (n = 1554) and Frederica Hospital (n = 499) for routine antenatal care were invited to participate in the study at their first visit...
January 30, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29369194/rapid-improvement-of-angiostenosis-due-to-isolated-middle-cerebral-artery-dissection-a-case-report
#6
Li Zhang, Guangxian Nan, Ying Mao, Lumei Chi
RATIONALE: Intracranial arterial dissection is a rare cause of ischemic stroke, and isolated middle cerebral artery dissection (MCAD) is extremely rare, having been described only in sparse case reports. The etiology, clinicoradiological features, and treatment strategies are not yet well understood. PATIENT CONCERNS: A 49-year-old man presented with rapidly progressive aphasia and motor disturbance of the right limbs. DIAGNOSES: Neuroimaging evaluation confirmed a diagnosis of MCAD and cerebral infarction...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29363872/evolutionary-analyses-of-the-avirulence-effector-avrstb6-in-global-populations-of-zymoseptoria-tritici-identify-candidate-amino-acids-involved-in-recognition
#7
Patrick C Brunner, Bruce A McDonald
We analyzed the population genetic diversity for AvrStb6, the first avirulence gene cloned from the wheat pathogen Zymoseptoria tritici, using 142 Z. tritici strains sampled from four wheat fields growing on three continents. Though AvrStb6 was located in a recombination hotspot, it was found in every strain, with 71 polymorphic sites that produced 41 distinct DNA haplotypes encoding 30 AvrStb6 protein isoforms. An AvrStb6 homolog was found in the closest known relative, Z. pseudotritici, but not in three other closely related Zymoseptoria species, indicating that this gene emerged in Zymoseptoria quite recently...
January 24, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29363162/inflammatory-monocytes-contribute-to-the-persistence-of-cxcr3hi-cx3cr1lo-circulating-and-lung-resident-memory-cd8-t-cells-following-respiratory-virus-infection
#8
Pritesh Desai, Vikas Tahiliani, Jessica Stanfield, Georges Abboud, Shahram Salek-Ardakani
Phenotypically diverse memory CD8+ T cells are present in the lungs that either re-circulate or reside within the tissue. Understanding the key cellular interactions that regulate the generation and then persistence of these different subsets is of great interest. Recently, DNGR-1+ dendritic cell (DC) mediated priming was reported to control the generation of lung resident but not circulating memory cells following respiratory viral infection. Here, we report an important role for Ly6C+ inflammatory monocytes (IMs) in contributing to the persistence of memory CD8+ T cells but not their generation...
January 4, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29362630/spontaneous-anterior-lens-capsule-rupture-of-a-patient-with-alport-syndrome-a-case-report
#9
Kalina Trifonova, George Jordanoff, Valentin Stoyanov, Kiril Slaveykov
BACKGROUND: Alport syndrome is a progressive genetic disease which is characterised by glomerulonephritis, sensorineural deafness and ocular abnormalities. We aimed to present a clinical case of a patient with Alport syndrome with spontaneous anterior lens capsule rupture. CASE REPORT: A 16-year-old male with histologically proven Alport syndrome was hospitalised in the Department of Ophthalmology, University Hospital "Prof. Stoyan Kirkovich", Stara Zagora with low vision, pain, redness, high IOP and rupture of the anterior lenticular capsule of the right eye...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29360168/activity-dependent-plasticity-of-presynaptic-gabab-receptors-at-parallel-fiber-synapses
#10
Adeline Orts-Del'Immagine, Jason R Pugh
Parallel fiber synapses in the cerebellum express a wide range of presynaptic receptors. However, presynaptic receptor expression at individual parallel fiber synapses is quite heterogeneous, suggesting physiological mechanisms regulate presynaptic receptor expression. We investigated changes in presynaptic GABAB receptors at parallel fiber-stellate cell synapses in acute cerebellar slices from juvenile mice. GABAB receptor-mediated inhibition of EPSCs is remarkably diverse at these synapses, with transmitter release at some synapses inhibited by more than 50% and little or no inhibition at others...
January 23, 2018: Synapse
https://www.readbyqxmd.com/read/29350807/mait-cells-and-viruses
#11
James E Ussher, Christian B Willberg, Paul Klenerman
Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially-derived metabolites. Functionally they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1. Viruses cannot generate these ligands, so a priori, they should not be recognized by MAIT cells and indeed this is true when considering recognition through the TCR. However, MAIT cells are distinctive in another respect, since they respond quite sensitively to non-TCR signals, especially in the form of inflammatory cytokines...
January 19, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29325982/multiple-cerebral-infarct-with-cerebral-vasculitis-in-a-young-patient-with-ulcerative-colitis
#12
Maeng Real Park, Mun Ki Min, Ji Ho Ryu, Dae Sub Lee, Kang Ho Lee
Ulcerative colitis (UC) is a chronic and debilitating disorder, characterized by inflammation of the colonic mucosa. UC can be considered a systemic disorder but UC-related manifestations in the central nervous system (CNS) are quite rare. A 29-year-old man was admitted to the emergency department with repeated generalized tonic-clonic (GTC) type seizures. Based on brain CT, brain metastasis or hemorrhagic infarct was suspected. Diffusion-weighted image of brain MRI showed high signal in the left thalamus and heterogenous enhancement in the right parietal and left frontal lobes...
January 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29323708/microrna501-5p-induces-p53-proteasome-degradation-through-the-activation-of-the-mtor-mdm2-pathway-in-adpkd-cells
#13
Lucia de Stephanis, Alessandra Mangolini, Miriam Servello, Peter C Harris, Lucio Dell'Atti, Paolo Pinton, Gianluca Aguiari
Cell proliferation and apoptosis are typical hallmarks of autosomal dominant polycystic kidney disease (ADPKD) and cause the development of kidney cysts that lead to end-stage renal disease (ESRD). Many factors, impaired by polycystin complex loss of function, may promote these biological processes, including cAMP, mTOR and EGFR signalling pathways. In addition, microRNAs (miRs) may also regulate the ADPKD related signalling network and their dysregulation contributes to disease progression. However, the role of miRs in ADPKD pathogenesis has not been fully understood, but also the function of p53 is quite obscure, especially its regulatory contribution on cell proliferation and apoptosis...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29319908/integrating-bayesian-genomic-cline-analyses-and-association-mapping-of-morphological-and-ecological-traits-to-dissect-reproductive-isolation-and-introgression-in-a-louisiana-iris-hybrid-zone
#14
Cheng-Jung Sung, Katherine L Bell, Chris C Nice, Noland H Martin
Hybrid zones provide unique opportunities to examine reproductive isolation and introgression in nature. We utilized 45,384 Single Nucleotide Polymorphism (SNP) loci to perform association mapping of 14 floral, vegetative, and ecological traits that differ between Iris hexagona and Iris fulva, and to investigate, using a Bayesian Genomic Cline (BGC) framework, patterns of genomic introgression in a large and phenotypically diverse hybrid zone in southern Louisiana. Many loci of small effect-size were consistently found to be associated with phenotypic variation across all traits, and several individual loci were revealed to influence phenotypic variation across multiple traits...
January 10, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29297152/the-thalamo-cortical-resting-state-functional-connectivity-and-abstinence-induced-craving-in-young-smokers
#15
Chaoyan Wang, Yong Zhang, Chenyu Yan, Mengtian Sun, Jingliang Cheng
Craving is a significant predicator of smoking relapse. Thus, revealing the neural correlates of craving to smoke in young smokers is important to improve the success of quit attempts. The abstinence-induced craving to smoke has not been explored extensively, although previous studies had investigated the neural substrates of cue-induced craving. Especially, the critical roles of thalamus had been revealed in cigarettes smoking. However, the implication of thalamus resting state functional connectivity (RSFC) in abstinence-induced craving remains unclear...
January 3, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29281851/commentary-to-patients-not-patents-drug-research-and-development-as-a-public-enterprise
#16
Gerard Marshall Raj
First, I would like to congratulate the author for coming up with an innovative patent-less non-private model for the health care system. The author's statements are quite intriguing. However, I do have some queries and comments. The initial paragraph appears to be more cynical - as the novel drug molecules are not really 'new'. This point-of-view of the author could be more balanced and more non-regional (other than France). This article is protected by copyright. All rights reserved.
December 27, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29281179/a-high-parasite-density-environment-induces-transcriptional-changes-and-cell-death-in-plasmodium-falciparum-blood-stages
#17
Evelyn S Chou, Sabia Z Abidi, Marian Teye, Aleksandra Leliwa-Sytek, Thomas S Rask, Simon A Cobbold, Gerry Q Tonkin-Hill, Krishanthi S Subramaniam, Anna E Sexton, Darren J Creek, Johanna P Daily, Michael F Duffy, Karen P Day
Transient regulation of Plasmodium numbers below the density that induces fever has been observed in chronic malaria infections in humans. This species transcending control cannot be explained by immunity alone. Using an in vitro system we have observed density dependent regulation of malaria population size as a mechanism to possibly explain these in vivo observations. Specifically, Plasmodium falciparum blood stages from a high but not low-density environment exhibited unique phenotypic changes during the late trophozoite (LT) and schizont stages of the intraerythrocytic cycle...
December 27, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29280257/experiences-of-mental-health-nursing-staff-working-with-voice-hearers-in-an-acute-setting-an-interpretive-phenomenological-approach
#18
Elaine McMullan, Anjula Gupta, Sylvie Collins
INTRODUCTION: Mental health nursing (MHN) staff in acute settings work with voice hearers at times of crises when experiencing high levels of distress. Previous research has focused on community mental health staff experiences and their service users views on exploring the content of voices. No studies have explored this from an acute mental health service perspective. AIM: The present study therefore sought to explore staff experiences of working with voice hearers in an acute mental health service...
December 27, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29249615/transcultural-pain-management-theory-practice-and-nurse-client-partnerships
#19
REVIEW
William E Rosa
Nursing is becoming increasingly aware of its impact as a global profession. Part of this evolution is the understanding that the Western evidence-based construct may not be reliably or universally applicable to transcultural settings and clients. In a global world, no 'one size fits all' and no singular approach to pain management is appropriate; there are, quite literally, infinite variations in cross-cultural dynamics. Nurses working in the field of pain management must be able to navigate their responsibilities within the global health context...
December 14, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#20
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
keyword
keyword
27961
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"