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Anetta Undas, Tadeusz Góralczyk
Direct oral anticoagulants (DOACs) or non-vitamin K oral anticoagulants (NOACs) are increasingly used in the prevention of recurrent venous thromboembolism (VTE), including that associated with thrombophilia. The efficacy of DOACs in thrombophilic patients, especially those with severe trombophilia or triple positive antiphospholipid syndrome (APS) with arterial thromboembolic events, remains controversial. Most case reports and case series indicate that DOACs are an attractive therapeutic option in the vast majority of these patients at high risk of recurrent VTE with more concerns raised in high-risk APS patients and these deficient in protein S (PS)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Marina Sprem Goldstajn, Daria Kovacević
Thrombophilia is a group of inherited and acquired coagulation disorders often associated with an increased risk of thrombosis. Over the last decade, inherited thrombophilia is often referred as a possible cause of recurrent miscarriages and in vitro fertilisation (IVF) failure. However, many studies in this area still give conflicting results, so the goal of our study was to determine the effect of thrombophilia on pregnancy outcome and success of IVF. The study included 38 patients with proven gene mutation for thrombophilia and 53patients without mutations...
December 2014: Collegium Antropologicum
José Daniel Flores-Alatriste, Sara Jacobo-Nájera, Rubén Segura-Rodríguez, Jorge Jaroslav Stern-Colin y Nunes
BACKGROUND: Inherited thrombophilia is a genetic tendency to suffer thrombotic events clinically evident at an early age, with frequent re- currences without apparent cause. In recent years thrombophilia has earned a place as a primary risk factor for abnormal pregnancy. OBJECTIVE: To determine the incidence of hereditary thrombophilia in patients with recurrent pregnancy loss. MATERIAL AND METHOD: A retrospective, linear and descriptive study was conducted at Clinic of Reproduction IMMUNOREP with patients treated from January 2007 to December 2012...
June 2014: Ginecología y Obstetricia de México
Waldemar Elikowski, Małgorzata Małek, Jolanta Kurosz, Alina Podkowińska, Magdalena Lukowiak-Głębocka, Krystyna Zawilska
It is a popular belief, that marijuana smoking is not harmful to health. Some publications, however, suggest its possible association with mental, respiratory and cardiovascular complications, but not with venous thromboembolism. The authors describe a case of severe pulmonary embolism in a mildly obese, 22 year-old marijuana and tobacco smoker. After thrombolysis, rapid haemodynamic improvement was observed, contrary to slow regression of concomitant deep vein thrombosis during anticoagulation with warfarin...
2011: Kardiologia Polska
S V Sin'kov, I B Zabolotskikh, G A Penzhoian, V P Muzychenko
One of the major causes of maternity death are complications of venous thromboembolism (VT). Risk of their occurrence during pregnancy is 5 to 10 times higher comparing to non-pregnant women. Hereditary trombophilia and antiphospholipid syndrome increase the risk of complications of venous thromboembolism significantly. In addition to VT, trombophilia is associated with miscarriage, placental abruption and severe preeclampsia. The aggravating factor is the presence of certain limitations in administration of some medications for thrombosis prophylaxis during pregnancy...
March 2011: Anesteziologiia i Reanimatologiia
Silvia D'Ippolito, Amparo Santamaria Ortiz, Manuela Veglia, Chiara Tersigni, Nicoletta Di Simone
Low molecular weight heparins (LMWHs) are widely used during pregnancy since several randomized controlled trials have demonstrated their important role in preventing not only thromboembolic disease but also pregnancy complications associated with thrombophilia: recurrent pregnancy loss (RPL), fetal growth restriction (FGR), preeclampsia (PE), abruptio placentae and intrauterine fetal death (IUFD). LMWHs have revealed their effectiveness in reducing the recurrence of negative obstetrics events even in patients without known trombophilias, despite the mechanisms whereby LMWHs operate remain still unclear...
July 2011: Reproductive Sciences
V Melus, G Kiricova, M Simek
OBJECTIVE: Mutations in hemocoagulation factors genes are nowadays routinely examined parameters, important in hereditary trombophilia determination. We have complexly evaluated laboratory data from the 211 unselected patients with venous thrombosis, and compared with the former studies in the same Slovakian population. RESULTS: The Factor V Leiden mutation (FVL) was found in 43 of 211 patients (20.38%), with the mutant allele frequency=10.2%, while the prothrombine G20210A mutation was revealed in 11/205 individuals (5...
2009: Bratislavské Lekárske Listy
Beata Wozakowska-Kapłon, Kinga Szydziak-Zwierzyńska
We present a case of a 45-year-old-female who developed myocardial infarction and 6 weeks following first hospitalisation--pulmonary embolism. The disease was probably triggered by hormone replacement therapy. Coronary angioplasty and anticoagulant therapy with unfractioned heparin and acenokumarol were used with success. The woman and her 17-year-old daughter were shown to be heterozygous for prothrombin mutation G20210A. This case shows that trombophilia should be considered in young women with deep venous thrombosis, pulmonary embolism, venous thromboembolism or with myocardial infarction especially in women with high-risk factors...
February 2009: Kardiologia Polska
S Smírová, M Chochola, P Varejka, M Aschermann
Deep vein thrombosis is a serious complication of oral contraception. The most serious complication, pulmonary embolism, could be lethal. The relative risk of thromboembolic disease is four time higher in women using oral contraception. Both the amount of estrogen and the type of gestagen can increase the relative risk of thromboembolic disease. Oral contraceptives influence procoagulants, fibrinolytic system and inhibitors of coagulation. The choice of oral contraceptive should be very careful. It is advised to use preparations with less then 50 micrograms of ethinyl-estradiol and the type of gestagen that has minimal metabolic side effects, including minimal effect on coagulation...
July 2001: Vnitr̆ní Lékar̆ství
V Cuevas, J I Tortosa, C Rodríguez, J M Alonso, L J García Frade
Resistance to activated protein C (RAPC) has been described recently as a cause of trombophilia; this may justify up to 50% of thromboembolic disease without predisposing cause in patients under 45 years. A 29 years-old male with a previous deep venous thrombosis (DVT) in the lower left limb three years earlier, developed a DVT in the right lower limb after a trauma of the knee that required immobilization, was associated to pulmonary thromboembolism diagnosed by gammagraphic methods. The phlebographic study showed femoro-iliaco-caval venous thrombosis...
August 1994: Sangre
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