C C Parker, P M Petersen, A D Cook, N W Clarke, C Catton, W R Cross, H Kynaston, W R Parulekar, R A Persad, F Saad, L Bower, G C Durkan, J Logue, C Maniatis, D Noor, H Payne, J Anderson, A K Bahl, F Bashir, D M Bottomley, K Brasso, L Capaldi, P W Cooke, C Chung, J Donohue, B Eddy, C M Heath, A Henderson, A Henry, R Jaganathan, H Jakobsen, N D James, J Joseph, K Lees, J Lester, H Lindberg, A Makar, S L Morris, N Oommen, P Ostler, L Owen, P Patel, A Pope, R Popert, R Raman, V Ramani, A Røder, I Sayers, M Simms, V Srinivasan, S Sundaram, K L Tarver, A Tran, P Wells, J Wilson, A M Zarkar, M K M Parmar, M R Sydes
BACKGROUND: The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for PSA failure. METHODS: RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, pre-op PSA≥10ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ("Adjuvant-RT") or an observation policy with salvage RT for PSA failure ("Salvage-RT") defined as PSA≥0...
April 5, 2024: Annals of Oncology: Official Journal of the European Society for Medical Oncology