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https://www.readbyqxmd.com/read/27716793/outcomes-definitions-and-statistical-tests-in-oncology-studies-a-systematic-review-of-the-reporting-consistency
#1
Romain Rivoirard, Vianney Duplay, Mathieu Oriol, Fabien Tinquaut, Franck Chauvin, Nicolas Magne, Aurelie Bourmaud
BACKGROUND: Quality of reporting for Randomized Clinical Trials (RCTs) in oncology was analyzed in several systematic reviews, but, in this setting, there is paucity of data for the outcomes definitions and consistency of reporting for statistical tests in RCTs and Observational Studies (OBS). The objective of this review was to describe those two reporting aspects, for OBS and RCTs in oncology. METHODS: From a list of 19 medical journals, three were retained for analysis, after a random selection: British Medical Journal (BMJ), Annals of Oncology (AoO) and British Journal of Cancer (BJC)...
2016: PloS One
https://www.readbyqxmd.com/read/27571555/-management-of-immune-related-adverse-events-during-treatment-with-immune-checkpoint-inhibitors
#2
Paola Queirolo, Francesco Spagnolo
Immunotherapy with anti-CTLA-4 and anti-PD-1 monoclonal antibodies is a breakthrough in the treatment of advanced cancer. The progressively broader indications of such drugs highlights the need of developing algorithms for the management of immune-related toxicities, as some adverse events may cause sequelae and even death if not managed effectively. Thanks to the collaboration of different specialist from the Gustave Roussy Institute in Paris, guidelines for the management of toxicities during treatment with immune checkpoint inhibitors were recently published on the journal Annals of Oncology...
August 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27334224/benchmarking-the-scientific-and-educational-impact-of-the-annals-of-surgical-oncology
#3
EDITORIAL
Charles M Balch, V Suzanne Klimberg, Kelly M McMasters, Timothy M Pawlik, Kenneth K Tanabe, Mitchell C Posner, Deborah Whippen, Mark S Roh
No abstract text is available yet for this article.
September 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27229330/a-look-inside-the-mechanistic-black-box-are-red-blood-cells-the-critical-effectors-of-rrx-001-cytotoxicity
#4
Pedro Cabrales, Jan Scicinski, Tony Reid, Frans Kuypers, Sandra Larkin, Marcel Fens, Arnold Oronsky, Bryan Oronsky
The therapeutic potential of epi-immunotherapeutic anticancer agent RRx-001 in cancer has been validated with preclinical and clinical studies, since RRx-001 has successfully completed a phase 1 trial and multiple single-agent and combination phase 2 trials with preliminary evidence of promising activity are underway. Previous experimental work has implicated diverse anticancer mechanisms such as oxidative stress, ATP and NADPH depletion, anti-angiogenesis and epigenetic modulation in the overall antitumor effect of RRx-001...
July 2016: Medical Oncology
https://www.readbyqxmd.com/read/26820660/-advanced-prostate-cancer-consensus-conference-apccc-2015-in-st-%C3%A2-gallen-critical-review-of-the-recommendations-on-diagnosis-and-therapy-of-metastatic-prostate-cancer-by-a-german-expert-panel
#5
C Thomas, M Bögemann, F König, S Machtens, M Schostak, T Steuber, A Heidenreich
In March 2015, the first Advanced Prostate Cancer Consensus Conference (APCC) took place in St. Gallen. 41 experts from 17 countries reviewed important areas of controversy in advanced hormone-naive and castration-resistant prostate cancer and gave therapy recommendations. These results have been recently published in "Annals of Oncology". While most of the recommendations from St. Gallen are comprehensible, some of them need to be further discussed. Therefore, we as a German expert panel will critically debate the St...
June 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/26629440/customizing-chemotherapy-in-non-small-cell-lung-cancer-the-promise-is-still-unmet
#6
John Souglakos
A combination of cytotoxic agents with cis-platin remains the cornerstone of treatment for the vast majority of patients with non-small cell lung cancer (NSCLC). Molecular analysis of the primary may lead better prognostication and eventually in more accurate therapeutic approaches. Data from retrospective analysis of randomized trials as well as large patients' series have suggested that chemotherapy may be customized upon molecular-genetic analysis of the tumor cells. The Spanish Lung Cancer Group (SLCG) in collaboration with French lung Cancer Group (FLCG) had conduct randomized, phase III, biomarkers-driven trial and supported simultaneously a randomized phase II trial in collaborating centers in China...
October 2015: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/26598539/annals-of-oncology-in-2015-the-year-in-review
#7
EDITORIAL
J-C Soria
No abstract text is available yet for this article.
January 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/26368744/nine-year-change-in-statistical-design-profile-and-success-rates-of-phase-ii-oncology-trials
#8
REVIEW
Anastasia Ivanova, Barry Paul, Olga Marchenko, Guochen Song, Neerali Patel, Stergios J Moschos
We investigated nine-year trends in statistical design and other features of Phase II oncology clinical trials published in 2005, 2010, and 2014 in five leading oncology journals: Cancer, Clinical Cancer Research, Journal of Clinical Oncology, Annals of Oncology, and Lancet Oncology. The features analyzed included cancer type, multicenter vs. single-institution, statistical design, primary endpoint, number of treatment arms, number of patients per treatment arm, whether or not statistical methods were well described, whether the drug was found effective based on rigorous statistical testing of the null hypothesis, and whether the drug was recommended for future studies...
2016: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/26104927/does-cancer-literature-reflect-multidisciplinary-practice-a-systematic-review-of-oncology-studies-in-the-medical-literature-over-a-20-year-period
#9
REVIEW
Emma B Holliday, Awad A Ahmed, Stella K Yoo, Reshma Jagsi, Karen E Hoffman
PURPOSE: Quality cancer care is best delivered through a multidisciplinary approach requiring awareness of current evidence for all oncologic specialties. The highest impact journals often disseminate such information, so the distribution and characteristics of oncology studies by primary intervention (local therapies, systemic therapies, and targeted agents) were evaluated in 10 high-impact journals over a 20-year period. METHODS AND MATERIALS: Articles published in 1994, 2004, and 2014 in New England Journal of Medicine, Lancet, Journal of the American Medical Association, Lancet Oncology, Journal of Clinical Oncology, Annals of Oncology, Radiotherapy and Oncology, International Journal of Radiation Oncology, Biology, Physics, Annals of Surgical Oncology, and European Journal of Surgical Oncology were identified...
July 15, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26041764/management-of-patients-with-advanced-prostate-cancer-recommendations-of-the-st-gallen-advanced-prostate-cancer-consensus-conference-apccc-2015
#10
S Gillessen, A Omlin, G Attard, J S de Bono, E Efstathiou, K Fizazi, S Halabi, P S Nelson, O Sartor, M R Smith, H R Soule, H Akaza, T M Beer, H Beltran, A M Chinnaiyan, G Daugaard, I D Davis, M De Santis, C G Drake, R A Eeles, S Fanti, M E Gleave, A Heidenreich, M Hussain, N D James, F E Lecouvet, C J Logothetis, K Mastris, S Nilsson, W K Oh, D Olmos, A R Padhani, C Parker, M A Rubin, J A Schalken, H I Scher, A Sella, N D Shore, E J Small, C N Sternberg, H Suzuki, C J Sweeney, I F Tannock, B Tombal
The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection...
August 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/25962441/-industry-corner-perspectives-and-controversies-a-new-series-in-annals-of-oncology
#11
EDITORIAL
K Dhingra
No abstract text is available yet for this article.
July 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/25904726/-statistical-controversies-in-clinical-research-a-new-series-in-annals-of-oncology
#12
EDITORIAL
J-C Soria, M Buyse
No abstract text is available yet for this article.
August 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/25561759/quantitative-index-calculated-by-99m-tc-gsa-scintigraphy
#13
Morikatsu Yoshida, Shinya Shiraishi, Noriko Tsuda, Fumi Sakamoto, Seiji Tomiguchi, Yasuyuki Yamashita
(99m)Tc-galactosyl human serum albumin (GSA) scintigraphy is useful to evaluate hepatic function and hepatic functional reserve. A reliable SPECT and CT integrated system is now commercially available. Using this system, we can obtain (99m)Tc-GSA SPECT/CT fused imaging with a small registration error. Therefore, the (99m)Tc-GSA scintigraphy techniques prove more useful in clinical practice than have been previously reported. In the latest Annals of Surgical Oncology on Oct 2014, the uptake index (UI) values calculated from (99m)Tc-GSA scintigraphy are reported to be useful for predicting the functional reserve of the future remnant liver...
December 2014: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/25493250/biochemical-prognostic-indicators-for-pancreatic-neuroendocrine-tumors-and-small-bowel-neuroendocrine-tumors
#14
Christine S Landry, Keith Cavaness, Scott Celinski, John Preskitt
Pancreatic neuroendocrine tumors (PNETs) and small bowel neuroendocrine tumors (SBNETs) are rare tumors that are frequently diagnosed late in the course of the disease. Several biomarkers have been proposed in the literature as prognostic factors for patients with these tumors. This article discusses a recent publication in Annals of Surgical Oncology from the University of Iowa analyzing the effect of different biomarkers on survival in patients with PNETs and SBNETs.
November 2014: Gland Surgery
https://www.readbyqxmd.com/read/25452455/hereditary-colorectal-cancer-syndromes-american-society-of-clinical-oncology-clinical-practice-guideline-endorsement-of-the-familial-risk-colorectal-cancer-european-society-for-medical-oncology-clinical-practice-guidelines
#15
Elena M Stoffel, Pamela B Mangu, Stephen B Gruber, Stanley R Hamilton, Matthew F Kalady, Michelle Wan Yee Lau, Karen H Lu, Nancy Roach, Paul J Limburg
PURPOSE: To provide recommendations on prevention, screening, genetics, treatment, and management for people at risk for hereditary colorectal cancer (CRC) syndromes. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. METHODS: The Familial Risk-Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guideline published in 2013 on behalf of the European Society for Medical Oncology (ESMO) Guidelines Working Group in Annals of Oncology was reviewed for developmental rigor by methodologists, with content and recommendations reviewed by an ASCO endorsement panel...
January 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/25216601/annals-of-surgical-oncology-the-first-20-years
#16
EDITORIAL
Charles M Balch, Mark S Roh, Deborah Whippen, V Suzanne Klimberg
No abstract text is available yet for this article.
November 2014: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25031996/the-need-for-communication-skills-training-in-oncology
#17
REVIEW
Dany Michaella Hilaire
Communication between health-care professionals and their patients is an element that can make all the difference in how those patients navigate their cancer journey. In a 2011 issue of the Annals of Oncology, Barth and Lannen reported on their systematic review and meta-analysis of the efficacy of communication skills training courses in oncology. In this issue of JADPRO, two authors share their perspectives on the findings of Barth and Lannen and what advanced practitioners (APs) can learn from their research...
May 2013: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/25021999/ptu-124%C3%A2-an-external-validation-of-the-hepatoma-arterial-embolisation-prognosis-hap-score-the-liverpool-experience
#18
O Noorullah, Vp Lekharaju, Iu Din, J Klcova, T Cross, J Evans, R Sturgess, D Palmer, E O'Grady, N Stern
INTRODUCTION: Most Hepatocellular Carcinomas (HCCs) have palliative treatment. Trans-arterial embolisation (TAE) or chemoembolisation (TACE) are used with variable results. The HAP score was recently described to determine patients likely to benefit from TAE or TACE. We report our experience with TAE and TACE to assess whether the HAP score was valid for our cohort of patients. METHODS: Retrospective review of cases given TAE or TACE in Liverpool, UK (2006-2013)...
June 2014: Gut
https://www.readbyqxmd.com/read/25021630/pwe-139%C3%A2-tace-in-the-management-of-hcc-in-a-regional-centre-5-year-analysis-and-assessment-of-predictors-of-outcome
#19
Id Morrison, R Kasthuri, Eh Forrest, S Barclay, R Gillespie, Pr Mills, M Priest, J Evans, Aj Stanley
INTRODUCTION: Transarterial chemoembolisation (TACE) is a useful treatment for selected patients unsuitable for surgical management of hepatocellular carcinoma (HCC). The Hepatoma Arterial-embolization Prognostic (HAP) score has been proposed to be a a better predictor of post-TACE outcome than the Child-Pugh or BCLC (Barcelona clinic liver cancer) scores.(1) METHODS: Patients diagnosed with HCC from January 2008 until December 2012 were identified from a prospectively compiled regional MDT database...
June 2014: Gut
https://www.readbyqxmd.com/read/24915873/association-between-cd8-t-cell-infiltration-and-breast-cancer-survival-in-12-439-patients
#20
RANDOMIZED CONTROLLED TRIAL
H R Ali, E Provenzano, S-J Dawson, F M Blows, B Liu, M Shah, H M Earl, C J Poole, L Hiller, J A Dunn, S J Bowden, C Twelves, J M S Bartlett, S M A Mahmoud, E Rakha, I O Ellis, S Liu, D Gao, T O Nielsen, P D P Pharoah, C Caldas
BACKGROUND: T-cell infiltration in estrogen receptor (ER)-negative breast tumours has been associated with longer survival. To investigate this association and the potential of tumour T-cell infiltration as a prognostic and predictive marker, we have conducted the largest study of T cells in breast cancer to date. PATIENTS AND METHODS: Four studies totalling 12 439 patients were used for this work. Cytotoxic (CD8+) and regulatory (forkhead box protein 3, FOXP3+) T cells were quantified using immunohistochemistry (IHC)...
August 2014: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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