keyword
https://read.qxmd.com/read/38534922/unlocking-the-potential-of-therapy-induced-cytokine-responses-illuminating-new-pathways-in-cancer-precision-medicine
#1
REVIEW
Dilip R Gunturu, Mohammed Hassan, Deepa Bedi, Pran Datta, Upender Manne, Temesgen Samuel
Precision cancer medicine primarily aims to identify individual patient genomic variations and exploit vulnerabilities in cancer cells to select suitable patients for specific drugs. These genomic features are commonly determined by gene sequencing prior to therapy, to identify individuals who would be most responsive. This precision approach in cancer therapeutics remains a powerful tool that benefits a smaller pool of patients, sparing others from unnecessary treatments. A limitation of this approach is that proteins, not genes, are the ultimate effectors of biological functions, and therefore the targets of therapeutics...
February 23, 2024: Current Oncology
https://read.qxmd.com/read/38528141/mirvetuximab-soravtansine-has-activity-in-platinum-sensitive-epithelial-ovarian-cancer
#2
JOURNAL ARTICLE
Diana Romero
No abstract text is available yet for this article.
March 25, 2024: Nature Reviews. Clinical Oncology
https://read.qxmd.com/read/38520743/single-cell-sequencing-illuminates-thymic-development-an-updated-framework-for-understanding-thymic-epithelial-tumors
#3
JOURNAL ARTICLE
Christopher S Nabel, Jeanne B Ackman, Yin P Hung, Abner Louissaint, Gregory J Riely
Thymic epithelial tumors (TETs) are rare tumors for which treatment options are limited. The ongoing need for improved systemic therapies reflects a limited understanding of tumor biology as well as the normal thymus. The essential role of the thymus in adaptive immunity is largely effected by its epithelial compartment, which directs thymocyte (T-cell) differentiation and immunologic self-tolerance. With aging, the thymus undergoes involution whereby epithelial tissue is replaced by adipose and other connective tissue, decreasing immature T-cell production...
March 23, 2024: Oncologist
https://read.qxmd.com/read/38519602/enhancing-diagnostic-precision-in-liver-lesion-analysis-using-a-deep-learning-based-system-opportunities-and-challenges
#4
JOURNAL ARTICLE
Jeong Min Lee, Jae Seok Bae
No abstract text is available yet for this article.
March 22, 2024: Nature Reviews. Clinical Oncology
https://read.qxmd.com/read/38518941/application-and-progress-of-nanozymes-in-antitumor-therapy
#5
REVIEW
Gaihua He, Chao Mei, Chenbo Chen, Xiao Liu, Jiaxuan Wu, Yue Deng, Ye Liao
Tumors remain one of the major threats to public health and there is an urgent need to design new pharmaceutical agents for their diagnosis and treatment. In recent years, due to the rapid development of nanotechnology, biotechnology, catalytic science, and theoretical computing, subtlety has gradually made great progress in research related to tumor diagnosis and treatment. Compared to conventional drugs, enzymes can improve drug distribution and enhance drug enrichment at the tumor site, thereby reducing drug side effects and enhancing drug efficacy...
March 20, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38517559/randomized-controlled-trial-of-an-app-for-cancer-pain-management
#6
JOURNAL ARTICLE
Lizhu Weng, Wanlong Lin, Xiuxian Lin, Maobai Liu, Jing Yang
PURPOSE: The primary objective of this investigation was to devise a mobile application for self-management of cancer-related discomfort, with the overarching goal of enhancing patients' overall well-being. Would the utilization of the self-management application result in an amelioration of life quality compared to conventional follow-up procedures? METHODS: Modules were meticulously devised with the collaborative expertise of oncology pain specialists employing the Delphi technique...
March 22, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38515565/ferroptosis-in-lung-cancer-dual-role-multi-level-regulation-and-new-therapeutic-strategies
#7
REVIEW
Yunbin Li, Xiaosong Li, Jian Li
Lung cancer is a highly prevalent malignant tumor worldwide, with high incidence and death rates. Recently, there has been increasing recognition of the role of ferroptosis, a unique cell death mechanism, in lung cancer. This review aims to summarize the current research progress on the relationship between ferroptosis and lung cancer. It also provides a comprehensive analysis of the regulatory processes of ferroptosis in various stages, including epigenetics, transcription, post-transcription, translation, and post-translation...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515194/decoding-the-glycoproteome-a-new-frontier-for-biomarker-discovery-in-cancer
#8
REVIEW
Kai He, Maryam Baniasad, Hyunwoo Kwon, Tomislav Caval, Gege Xu, Carlito Lebrilla, Daniel W Hommes, Carolyn Bertozzi
Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting circulating tumor cells (CTCs) and DNA (ctDNA) have shown enormous potential due to their non-invasive nature and the implications in precision cancer management. Recently, liquid biopsy has been further expanded to profile glycoproteins, which are the products of post-translational modifications of proteins and play key roles in both normal and pathological processes, including cancers...
March 22, 2024: Journal of Hematology & Oncology
https://read.qxmd.com/read/38514882/il-13r%C3%AE-2-targeted-car-t-cells-show-promise-in-patients-with-recurrent-high-grade-gliomas
#9
JOURNAL ARTICLE
David Killock
No abstract text is available yet for this article.
March 21, 2024: Nature Reviews. Clinical Oncology
https://read.qxmd.com/read/38512448/current-approaches-in-glioblastoma-multiforme-immunotherapy
#10
REVIEW
Marjan Aghajani, Nazila Jalilzadeh, Ali Aghebati-Maleki, Amirhossein Yari, Peyman Tabnak, Amirhossein Mardi, Hossein Saeedi, Leili Aghebati-Maleki, Behzad Baradaran
Glioblastoma multiform (GBM) is the most prevalent CNS (central nervous system) tumor in adults, with an average survival length shorter than 2 years and rare metastasis to organs other than CNS. Despite extensive attempts at surgical resecting, the inherently permeable nature of this disease has rendered relapse nearly unavoidable. Thus, immunotherapy is a feasible alternative, as stimulated immune cells can enter into the remote and inaccessible tumor cells. Immunotherapy has revolutionized patient upshots in various malignancies and might introduce different effective ways for GBM patients...
March 21, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38509965/identification-and-analysis-of-prognostic-metabolic-characteristics-in-colon-adenocarcinoma
#11
JOURNAL ARTICLE
Yang Yang, Xinyu Yang, Shiqi Ren, Yang Cao, Ziheng Wang, Zhouyang Cheng
Colon adenocarcinoma (COAD) is a highly lethal gastrointestinal malignancy. The five-year survival rate of metastatic colorectal cancer remains low, at 14 percent. Numerous publications have suggested a role for peroxisome proliferator-activated receptors (PPARs) in malignancy. Recent studies have shown that PPARs, as nuclear transcription factors, may serve as potential targets for the treatment of metabolic syndrome tumors and their associated complications. However, the molecular mechanism has not been thoroughly investigated...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509422/organoids-in-ovarian-cancer-a-platform-for-disease-modeling-precision-medicine-and-drug-assessment
#12
REVIEW
Haiyao Hu, Chong'en Sun, Jingyao Chen, Zhengyu Li
Ovarian cancer (OC) is a major cause of gynecological cancer mortality, necessitating enhanced research. Organoids, cellular clusters grown in 3D model, have emerged as a disruptive paradigm, transcending the limitations inherent to conventional models by faithfully recapitulating key morphological, histological, and genetic attributes. This review undertakes a comprehensive exploration of the potential in organoids derived from murine, healthy population, and patient origins, encompassing a spectrum that spans foundational principles to pioneering applications...
March 20, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38509334/a-new-standard-of-care-for-advanced-stage-urothelial-carcinoma
#13
JOURNAL ARTICLE
Peter Sidaway
No abstract text is available yet for this article.
March 20, 2024: Nature Reviews. Clinical Oncology
https://read.qxmd.com/read/38509333/identification-of-dynamic-microbiota-signatures-in-patients-with-melanoma-receiving-icis-opportunities-and-challenges
#14
JOURNAL ARTICLE
Saman Maleki Vareki, Diwakar Davar
No abstract text is available yet for this article.
March 20, 2024: Nature Reviews. Clinical Oncology
https://read.qxmd.com/read/38508788/radiotherapy-combined-with-intralesional-immunostimulatory-agents-for-soft-tissue-sarcomas
#15
REVIEW
Chang Su, Soo Kyoung Kim, Charles X Wang, David G Kirsch, Arta M Monjazeb
Immunotherapy has shifted the treatment paradigm for many types of cancer. Unfortunately, the most commonly used immunotherapies, such as immune checkpoint inhibitors (ICI), have yielded limited benefit for most types of soft tissue sarcoma (STS). Radiotherapy (RT) is a mainstay of sarcoma therapy and can induce immune modulatory effects. Combining immunotherapy and RT in STS may be a promising strategy to improve sarcoma response to RT and increase the efficacy of immunotherapy. Most combination strategies have employed immunotherapies, such as ICI, that derepress immune suppressive networks...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38505913/role-of-alpha-fetoprotein-in-the-pathogenesis-of-cancer
#16
JOURNAL ARTICLE
Alok Ghosh Chaudhuri, Saptadip Samanta, Monalisha Dey, N S Raviraja, Souvik Dey
Alpha-fetoprotein (AFP) belongs to the albuminoid protein family and is considered as the fetal analog of serum albumin. This plasma protein is initially synthesized in the fetal liver and yolk sac and shows a maximum peak near the end of the first trimester. Later, concentrations begin to decline prenatally and drop precipitously after birth. This protein has three key ligand-binding pockets for interactions with various biomolecules. It contains multiple phosphorylation and acetylation sites for the regulation of physiological and pathophysiological states...
2024: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/38504345/epigenetic-mlh1-silencing-concurs-with-mismatch-repair-deficiency-in-sporadic-naturally-occurring-colorectal-cancer-in-rhesus-macaques
#17
JOURNAL ARTICLE
Simon Deycmar, Brendan J Johnson, Karina Ray, George W Schaaf, Declan Patrick Ryan, Cassandra Cullin, Brandy L Dozier, Betsy Ferguson, Benjamin N Bimber, John D Olson, David L Caudell, Christopher T Whitlow, Kiran Kumar Solingapuram Sai, Emily C Romero, Francois J Villinger, Armando G Burgos, Hannah C Ainsworth, Lance D Miller, Gregory A Hawkins, Jeff W Chou, Bruno Gomes, Michael Hettich, Maurizio Ceppi, Jehad Charo, J Mark Cline
BACKGROUND: Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and are useful models for cancer immunotherapy; but mechanistic data are lacking regarding the comparative molecular pathogenesis of these cancers. METHODS: We conducted state-of-the-art imaging including CT and PET, clinical assessments, and pathological review of 24 rhesus macaques with naturally occurring CRC. Additionally, we molecularly characterized these tumors utilizing immunohistochemistry (IHC), microsatellite instability assays, DNAseq, transcriptomics, and developed a DNA methylation-specific qPCR assay for MLH1, CACNA1G, CDKN2A, CRABP1, and NEUROG1, human markers for CpG island methylator phenotype (CIMP)...
March 19, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38503878/claudin-18-2-as-a-novel-therapeutic-target
#18
REVIEW
Izuma Nakayama, Changsong Qi, Yang Chen, Yoshiaki Nakamura, Lin Shen, Kohei Shitara
Claudin 18.2, a tight-junction molecule predominantly found in the nonmalignant gastric epithelium, becomes accessible on the tumour cell surface during malignant transformation, thereby providing an appealing target for cancer therapy. Data from two phase III trials testing the anti-claudin 18.2 antibody zolbetuximab have established claudin 18.2-positive advanced-stage gastric cancers as an independent therapeutic subset that derives benefit from the addition of this agent to chemotherapy. This development has substantially increased the percentage of patients eligible for targeted therapy...
March 19, 2024: Nature Reviews. Clinical Oncology
https://read.qxmd.com/read/38496894/advancing-cancer-theranostics-through-biomimetics-a-comprehensive-review
#19
REVIEW
Kuttiappan Anitha, Santenna Chenchula, Vijayaraj Surendran, Bhatt Shvetank, Parameswar Ravula, Rhythm Milan, Radhika Chikatipalli, Padmavathi R
Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively analyses recent progress in biomimetics-based cancer theranostics, emphasizing its role in overcoming current treatment challenges, with a focus on breast, prostate, and skin cancers...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38495037/interplay-of-oncoplastic-reconstruction-and-adjuvant-radiation-therapy-in-breast-cancer
#20
JOURNAL ARTICLE
Ryan T Morse, Matthew Moreno, James A Butterworth, Melissa P Mitchell
PURPOSE: Oncoplastic breast surgery (OBS) combines breast cancer tumor removal with the cosmetic benefits of plastic surgery at the time of breast-conserving surgery. Potential advantages of OBS include wider surgical margins around the tumor bed, while the natural shape and appearance of the breast are maintained more than standard lumpectomy procedures. However, limited information is available regarding the potential effect on adjuvant radiation treatment planning. MATERIALS AND METHODS: Women with localized breast cancer undergoing lumpectomy with immediate OBS and adjuvant radiation therapy between 2014 and 2019 were reviewed...
March 2024: Advances in Radiation Oncology
keyword
keyword
27955
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.