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https://www.readbyqxmd.com/read/29134517/subcutaneous-ketamine-for-postoperative-pain-relief-in-rwanda-a-randomized-clinical-trial
#1
Calen Sacevich, Benjamin Semakuba, William P McKay, Shefali Thakore, Theogene Twagirumugabe, John Nyiligira
PURPOSE: Postoperative pain control is often inadequate in low-income countries such as Rwanda, prompting the search for an inexpensive improvement. A randomized controlled trial was conducted to study the use of subcutaneous ketamine for the management of postoperative pain in patients undergoing major surgery in Kigali, Rwanda. METHODS: Fifty-nine patients undergoing major abdominal, head and neck, plastic, or gynecological surgeries were studied. In addition to standard care, patients received five subcutaneous injections of ketamine 1 mg·kg(-1) (ketamine group, n = 30) or normal saline (placebo group, n = 29) during the postoperative period...
November 13, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29122860/genome-sequences-of-three-cluster-au-arthrobacter-phages-caterpillar-nightmare-and-teacup
#2
Tamarah L Adair, Emily Stowe, Marie C Pizzorno, Gregory Krukonis, Melinda Harrison, Steven G Cresawn, Rebecca A Garlena, Daniel A Russell, Welkin H Pope, Deborah Jacobs-Sera, Graham F Hatfull
Caterpillar, Nightmare, and Teacup are cluster AU siphoviral phages isolated from enriched soil on Arthrobacter sp. strain ATCC 21022. These genomes are 58 kbp long with an average G+C content of 50%. Sequence analysis predicts 86 to 92 protein-coding genes, including a large number of small proteins with predicted transmembrane domains.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29110681/treatment-of-sleep-disturbances-in-trauma-affected-refugees-study-protocol-for-a-randomised-controlled-trial
#3
Hinuga Sandahl, Poul Jennum, Lone Baandrup, Ida Sophie Poschmann, Jessica Carlsson
BACKGROUND: Sleep disturbances are often referred to as a hallmark and as core symptoms of post-traumatic stress disorder (PTSD). Untreated sleep disturbances can contribute to the maintenance and exacerbation of PTSD symptoms, which may diminish treatment response and constitute a risk factor for poor treatment outcome. Controlled trials on treatment of sleep disturbances in refugees suffering from PTSD are scarce. The present study aims to examine sleep-enhancing treatment in refugees with PTSD...
November 6, 2017: Trials
https://www.readbyqxmd.com/read/29109646/ludwig-s-angina-in-children-anesthesiologist-s-nightmare-case-series-and-review-of-literature
#4
Maitree Pandey, Manpreet Kaur, Manoj Sanwal, Aruna Jain, Sunil K Sinha
Ludwig's angina is potentially lethal, rapidly spreading cellulitis of the floor of mouth and neck. The anticipated difficult airway becomes even more challenging when it occurs in children. In children, the larynx is positioned relatively higher in the neck, and one does not have the option for blind nasal intubation or awake fiberoptic, which otherwise is the technique of choice in adult patients. We present the clinical course of 16 children and highlight various problems encountered during the anesthetic management of six children who required emergency surgical drainage under general anesthesia...
July 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29095474/molecular-dynamics-simulation-of-thermotropic-bolaamphiphiles-with-a-swallow-tail-lateral-chain-formation-of-cubic-network-phases
#5
Yangyang Sun, Poornima Padmanabhan, Mayank Misra, Fernando A Escobedo
T-shaped bolaamphiphiles (TBA) with a swallow-tail lateral chain have been found to provide a fertile platform to produce complex liquid crystalline phases that are accessible through changes of temperature and lateral chain length and design. In this work, we use molecular simulations of a simple coarse-grained model to map out the phase behavior of this type of molecules. This model is based on the premise that the crucial details of the fluid structure stem from close range repulsions and the strong directional forces typical of hydrogen bonds...
November 2, 2017: Soft Matter
https://www.readbyqxmd.com/read/29088961/the-21st-century-challenge-to-neurocritical-care-the-rise-of-the-superbug-acinetobacter-baumannii-a-meta-analysis-of-the-role-of-intrathecal-or-intraventricular-antimicrobial-therapy-in-reduction-of-mortality
#6
Nasser Mohammed, Amey R Savardekar, Devi Prasad Patra, Vinayak Narayan, Anil Nanda
OBJECTIVE Neurosurgical infections due to multidrug-resistant organisms have become a nightmare that neurosurgeons are facing in the 21st century. This is the dawn of the so-called postantibiotic era. There is an urgent need to review and evaluate ways to reduce the high mortality rates due to these infections. The present study evaluates the efficacy of combined intravenous plus intrathecal or intraventricular (IV + IT) therapy versus only intravenous (IV) therapy in treating postneurosurgical Acinetobacter baumannii infections...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29082852/a-glance-into-how-the-cold-war-and-governmental-loyalty-investigations-came-to-affect-a-leading-u-s-radiation-geneticist-lewis-j-stadler-s-nightmare
#7
REVIEW
Edward J Calabrese
This paper describes an episode in the life of the prominent plant radiation geneticist, Lewis J. Stadler (1897-1954) during which he became a target of the Federal Bureau of Investigation (FBI) concerning loyalty to the United States due to possible associations with the communist party. The research is based on considerable private correspondence of Dr. Stadler, the FBI interrogatory questions and Dr. Stadler's answers and letters of support for Dr. Stadler by leading scientists such as, Hermann J. Muller...
October 30, 2017: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/29081833/parent-reported-problematic-sleep-behaviors-in-children-with-comorbid-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#8
Katharine C Reynolds, Michelle Patriquin, Candice A Alfano, Katherine A Loveland, Deborah A Pearson
BACKGROUND: Sleep problems are frequent and well documented in children with Autism Spectrum Disorders (ASD), children with Attention Deficit/Hyperactivity Disorder (ADHD) and children with internalizing problems, however limited work has examined sleep problems in children presenting with comorbid ASD/ADHD. In healthy children, sleep problems negatively impact social, emotional, and academic functioning. The current study sought to examine diagnostic severity as predictors of sleep problems in children with comorbid ASD/ADHD...
July 2017: Research in Autism Spectrum Disorders
https://www.readbyqxmd.com/read/29075143/suicidality-in-sleep-disorders-prevalence-impact-and-management-strategies
#9
REVIEW
Christopher W Drapeau, Michael R Nadorff
Sleep disturbances are associated with suicide-related thoughts and behaviors, and the incidence of sleep concerns and suicide has increased recently in the US. Most published research exploring the sleep-suicidality relation is focused on select sleep disorders, with few reviews offering a comprehensive overview of the sleep-suicidality literature. This narrative review broadly investigates the growing research literature on sleep disorders and suicidality, noting the prevalence of suicide ideation and nonfatal and fatal suicide attempts, the impact of several sleep disorders on suicide risk, and potential sleep-disorder management strategies for mitigating suicide risk...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29074230/a-novel-differential-susceptibility-framework-for-the-study-of-nightmares-evidence-for-trait-sensory-processing-sensitivity
#10
REVIEW
Michelle Carr, Tore Nielsen
Research on nightmares has largely focused on the nightmare itself and its associated negative consequences, framing nightmare sufferers as victims of a diathesis-stress induced form of psychopathology. However, there is evidence that frequent nightmare recallers are sensitive to a wide range of sensory and emotional experiences, and report vivid, bizarre and even intensely positive dream and daydream experiences. We propose sensory processing sensitivity as a novel trait marker that underlies the unique symptoms and imaginative richness found in nightmare-prone individuals...
December 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29074095/the-midnight-bite-a-kissing-bug-nightmare
#11
Norman L Beatty, Stephen A Klotz
No abstract text is available yet for this article.
October 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29056416/the-mechanisms-of-action-underlying-the-efficacy-of-psychological-nightmare-treatments-a-systematic-review-and-thematic-analysis-of-discussed-hypotheses
#12
REVIEW
Andréanne Rousseau, Geneviève Belleville
Studies of psychotherapeutic treatments for nightmares have yielded support for their effectiveness. However, no consensus exists to explain how they work. This study combines a systematic review with a qualitative thematic analysis to identify and categorize the existing proposed mechanisms of action (MAs) of nightmare treatments. The systematic review allowed for a great number of scholarly publications on supported psychological treatments for nightmares to be identified. Characteristics of the study and citations regarding potential MAs were extracted using a standardized coding grid...
September 1, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29045498/novel-drug-targets-in-cell-wall-biosynthesis-exploited-by-gene-disruption-in-pseudomonas-aeruginosa
#13
Ayssar A Elamin, Susanne Steinicke, Wulf Oehlmann, Yvonne Braun, Hanaa Wanas, Eduard A Shuralev, Carmen Huck, Marko Maringer, Manfred Rohde, Mahavir Singh
For clinicians, Pseudomonas aeruginosa is a nightmare pathogen that is one of the top three causes of opportunistic human infections. Therapy of P. aeruginosa infections is complicated due to its natural high intrinsic resistance to antibiotics. Active efflux and decreased uptake of drugs due to cell wall/membrane permeability appear to be important issues in the acquired antibiotic tolerance mechanisms. Bacterial cell wall biosynthesis enzymes have been shown to be essential for pathogenicity of Gram-negative bacteria...
2017: PloS One
https://www.readbyqxmd.com/read/29038689/making-connections-exploring-the-centrality-of-posttraumatic-stress-symptoms-and-covariates-after-a-terrorist-attack
#14
Marianne Skogbrott Birkeland, Trond Heir
Background: Posttraumatic stress symptoms are interconnected. Knowledge about which symptoms of posttraumatic stress are more strongly interconnected or central than others may have implications for the targeting of clinical interventions. Exploring whether symptoms of posttraumatic stress may be differentially related to covariates can contribute to our knowledge on how posttraumatic stress symptoms arise and are maintained. Objective: This study aimed to identify the most central symptoms of posttraumatic stress and their interconnections, and to explore how covariates such as exposure, sex, neuroticism, and social support are related to the network of symptoms of posttraumatic stress...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29031754/predictors-of-insomnia-onset-in-adolescents-in-japan
#15
Mikiko Tokiya, Yoshitaka Kaneita, Osamu Itani, Maki Jike, Takashi Ohida
OBJECTIVE: The objective of this study was to clarify the incidence rate and predictive factors of insomnia in Japanese junior and senior high school students. METHODS: We conducted a baseline survey on first year junior and senior high school students (seventh and 10th graders) throughout the nation. A follow-up survey was then conducted two years later. For both surveys, we used self-administered questionnaires inquiring about sleep, mental health status, lifestyle, participation in club activities, and study hours...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29020358/cardiac-rejuvenation-a-new-hope-in-the-presbycardia-nightmare
#16
Andreu M Climent, Ricardo Sanz-Ruiz, Francisco Fernández-Avilés
No abstract text is available yet for this article.
August 24, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29016155/association-of-posttraumatic-nightmares-and-psychopathology-in-a-military-sample
#17
Thérèse de Dassel, Lutz Wittmann, Sonja Protic, Helge Höllmer, Robert J Gorzka
Nightmares are among the most frequent and disturbing symptoms of posttraumatic stress disorder (PTSD). However, basic research questions regarding key associations between certain nightmare characteristics, especially replicativeness, and posttraumatic psychopathology need further empirical elaboration. Sixty-two German soldiers (mean age 33.8 years, 17.7% females) admitted to a hospital-based treatment program for veterans completed extensive assessments consisting of clinical interviews and self-rating measures with respect to sociodemographic characteristics and psychopathology as well as dream-related variables...
October 9, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28972864/dna-barcoding-a-nightmare-taxon-assessing-barcode-index-numbers-and-barcode-gaps-for-sweat-bees
#18
Jason Gibbs
There is an ongoing campaign to DNA barcode the world's >20,000 bee species. Recent revisions of <i>Lasioglossum</i> (<i>Dialictus</i>) (Hymenoptera: Halictidae) for Canada and the eastern United States were completed using integrative taxonomy. DNA barcode data from 110 species of <i>L</i>. (<i>Dialictus</i>) are examined for their value in identification and discovering additional taxonomic diversity. Specimen identification success was estimated using the best close match method...
October 3, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28971612/adverse-drug-reactions-of-montelukast-in-children-and-adults
#19
Meindina G Haarman, Florence van Hunsel, Tjalling W de Vries
Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for the treatment of asthma in both children and adults. However, its effectiveness is debated, and recent studies have reported several adverse events such as neuropsychiatric disorders and allergic granulomatous angiitis. This study aims to obtain more insight into the safety profile of montelukast and to provide prescribing physicians with an overview of relevant adverse drug reactions in both children and adults. We retrospectively studied all adverse drug reactions on montelukast in children and adults reported to the Netherlands Pharmacovigilance Center Lareb and the WHO Global database, VigiBase(®) until 2016...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28960406/exploring-thematic-nightmare-content-and-associated-self-harm-risk
#20
Kevin D Hochard, Sam Ashcroft, Janine Carroll, Nadja Heym, Ellen Townsend
Nightmares have been shown to be robust predictors of self-harm risk, beyond depressive symptoms and hopelessness at times. However, few studies have investigated associations between nightmare content and increased self-harm risk. This study explored associations of thematic nightmare content with history of self-harm, and risk of self-harm phenomena the morning following a nightmare. A mixed-method diary study was performed. Prospective nightmare reports were obtained from 72 participants. A total of 47 nightmare reports met inclusion criteria and were analyzed for themes using inductive thematic analysis...
September 28, 2017: Suicide & Life-threatening Behavior
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