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Fluid goal-directed therapy in children

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https://www.readbyqxmd.com/read/27500722/treatment-of-pediatric-septic-shock-with-the-surviving-sepsis-campaign-guidelines-and-picu-patient-outcomes
#1
Jennifer K Workman, Stefanie G Ames, Ron W Reeder, E Kent Korgenski, Susan M Masotti, Susan L Bratton, Gitte Y Larsen
OBJECTIVES: The Surviving Sepsis Campaign recommends rapid recognition and treatment of severe sepsis and septic shock. Few reports have evaluated the impact of these recommendations in pediatrics. We sought to determine if outcomes in patients who received initial care compliant with the Surviving Sepsis Campaign time goals differed from those treated more slowly. DESIGN: Single center retrospective cohort study. SETTING: Emergency department and PICU at an academic children's hospital...
October 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26545173/respiratory-variation-in-aortic-blood-flow-peak-velocity-to-predict-fluid-responsiveness-in-mechanically-ventilated-children-a-systematic-review-and-meta-analysis
#2
REVIEW
François-Pierrick Desgranges, Olivier Desebbe, Edmundo Pereira de Souza Neto, Darren Raphael, Dominique Chassard
BACKGROUND: Dynamic indices of preload have been shown to better predict fluid responsiveness than static variables in mechanically ventilated adults. In children, dynamic predictors of fluid responsiveness have not yet been extensively studied. AIM: To evaluate the diagnostic accuracy of respiratory variation in aortic blood flow peak velocity (ΔVPeak) for the prediction of fluid responsiveness in mechanically ventilated children. METHOD: PubMed, Embase, and the Cochrane Database of Systematic Reviews were screened for studies relevant to the use of ΔVPeak to predict fluid responsiveness in children receiving mechanical ventilation...
January 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/24919492/the-golden-hours-in-paediatric-septic-shock-current-updates-and-recommendations
#3
REVIEW
Shu Ling Chong, Gene Y K Ong, Anantharaman Venkataraman, Yoke Hwee Chan
INTRODUCTION: Paediatric sepsis is a global health problem. It is the leading cause of mortality in infants and children worldwide. Appropriate and timely initial management in the first hours, often termed as the "golden hours", has great impact on survival. The aim of this paper is to summarise the current literature and updates on the initial management of paediatric sepsis. MATERIALS AND METHODS: A comprehensive literature search was performed via PubMed using the search terms: 'sepsis', 'septic shock', 'paediatric' and 'early goal-directed therapy'...
May 2014: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/24583504/early-goal-directed-therapy-in-pediatric-septic-shock-comparison-of-outcomes-with-and-without-intermittent-superior-venacaval-oxygen-saturation-monitoring-a-prospective-cohort-study
#4
COMPARATIVE STUDY
Jhuma Sankar, M Jeeva Sankar, C P Suresh, Nandkishore K Dubey, Archana Singh
OBJECTIVE: To evaluate the effect of intermittent central venous oxygen saturation monitoring (ScvO(2)) on critical outcomes in children with septic shock, as continuous monitoring may not be feasible in most resource-restricted settings. DESIGN: Prospective cohort study. SETTING: PICU of a tertiary care teaching hospital. PATIENTS: Consecutive children younger than 17 years with fluid refractory septic shock admitted to our ICU from November 2010 to October 2012 were included...
May 2014: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/24063133/-parenteral-fluid-therapy-in-the-pediatric-surgical-patient
#5
Yoshie Taniguchi
Perioperative fluid therapy aims to provide water, electrolytes and calorie to maintain metabolic homeostasis. The landmark article in which Holliday and Segar proposed the rate and composition of parenteral maintenance fluids for hospitalized children is used to the fluid management for the pediatric surgical patient. Critically ill patients require meticulous intraoperative fluid management to avoid acidosis, hypoglycemia, hyponatremia, and hypocalcemia as well as to maintain adequate intravascular volume...
September 2013: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/23883424/factors-affecting-pediatric-isotonic-fluid-resuscitation-efficiency-a-randomized-controlled-trial-evaluating-the-impact-of-syringe-size
#6
RANDOMIZED CONTROLLED TRIAL
Greg Harvey, Gary Foster, Asmaa Manan, Lehana Thabane, Melissa J Parker
BACKGROUND: Goal-directed therapy guidelines for pediatric septic shock resuscitation recommend fluid delivery at speeds in excess of that possible through use of regular fluid infusion pumps. In our experience, syringes are commonly used by health care providers (HCPs) to achieve rapid fluid resuscitation in a pediatric fluid resuscitation scenario. At present, it is unclear which syringe size health care providers should use when performing fluid resuscitation to achieve maximal fluid resuscitation efficiency...
July 24, 2013: BMC Emergency Medicine
https://www.readbyqxmd.com/read/23361625/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#7
R P Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Intensive Care Medicine
https://www.readbyqxmd.com/read/23354787/paediatric-community-acquired-septic-shock-results-from-the-repem-network-study
#8
MULTICENTER STUDY
P Van de Voorde, B Emerson, B Gomez, J Willems, D Yildizdas, I Iglowstein, E Kerkhof, N Mullen, C R Pinto, T Detaille, N Qureshi, J Naud, J De Dooy, R Van Lancker, A Dupont, N Boelsma, M Mor, D Walker, M Sabbe, S Hachimi-Idrissi, L Da Dalt, H Waisman, D Biarent, I Maconochie, H Moll, J Benito
UNLABELLED: INTRODUCTION AND PURPOSE OF THE STUDY: With this study we aimed to describe a "true world" picture of severe paediatric 'community-acquired' septic shock and establish the feasibility of a future prospective trial on early goal-directed therapy in children. During a 6-month to 1-year retrospective screening period in 16 emergency departments (ED) in 12 different countries, all children with severe sepsis and signs of decreased perfusion were included. RESULTS: A 270,461 paediatric ED consultations were screened, and 176 cases were identified...
May 2013: European Journal of Pediatrics
https://www.readbyqxmd.com/read/23353941/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#9
R Phillip Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven A Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/21541646/management-of-septic-shock
#10
Rakesh Lodha, Tejo Pratap Oleti, S K Kabra
Septic shock is an important cause of mortality in children with sepsis. The incidence of septic shock is 2-4% of admissions in western pediatric intensive care units and 40%-67% for Indian PICUs. Early goal-directed resuscitation that includes aggressive fluid resuscitation of up to 60 mL/kg as boluses of 20 mL/kg by IV push, to achieve desired heart rates and blood pressure, has emerged as mainstay of treatment in the initial stage. Crystalloids are the preferred fluids, while colloids may be used in some situations...
June 2011: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/21340485/the-european-paediatric-life-support-course-improves-assessment-and-care-of-dehydrated-children-in-the-emergency-department
#11
Gérard Chéron, Jean Philippe Jais, Bogdan Cojocaru, Nathalie Parez, Dominique Biarent
We tested the hypothesis that application of the principles learned from the European Paediatric Life Support (EPLS) course improves child health assessment and care. In a retrospective study, residents from five paediatric emergency departments were included. For each of them, we analysed five medical records of infants and children suffering from diarrhoea; three were in ambulatory care and two were in-hospital care with IV hydration. Two independent observers analysed the records using a standardized checklist of 14 clinical points, as well as three items to evaluate the adequacy of treatment according to hydration status...
September 2011: European Journal of Pediatrics
https://www.readbyqxmd.com/read/21339277/implementation-of-goal-directed-therapy-for-children-with-suspected-sepsis-in-the-emergency-department
#12
Andrea T Cruz, Andrew M Perry, Eric A Williams, Jeanine M Graf, Elizabeth R Wuestner, Binita Patel
BACKGROUND: Suboptimal care for children with septic shock includes delayed recognition and inadequate fluid resuscitation. OBJECTIVE: To describe the implementation of an emergency department (ED) protocol for the recognition of septic shock and facilitate adherence to national treatment guidelines. PATIENTS AND METHODS: Root-cause analyses and morbidity and mortality conferences identified system problems with sepsis recognition and management...
March 2011: Pediatrics
https://www.readbyqxmd.com/read/21057288/updated-american-college-of-critical-care-medicine-pediatric-advanced-life-support-guidelines-for-management-of-pediatric-and-neonatal-septic-shock-relevance-to-the-emergency-care-clinician
#13
Niranjan Kissoon, Richard A Orr, Joseph A Carcillo
Shock is a major preventable cause of morbidity and mortality in children referred to emergency care. The recently updated American College of Critical Care Medicine guidelines for the management of newborns and children with septic shock emphasize the role of emergency care in improving survival and functional outcomes. Implementation of these guidelines of stepwise use of fluids, antibiotics, and, if necessary, inotropes within the first hour of admission to the emergency department can reduce mortality and neurological morbidity risks 2-fold...
November 2010: Pediatric Emergency Care
https://www.readbyqxmd.com/read/20523274/early-goal-directed-therapy-in-treatment-of-pediatric-septic-shock
#14
REVIEW
Cláudio Flauzino de Oliveira
In the whole world, around 29,000 children younger than 5 years die every day, and sepsis is the most common cause of death. Whereas in adult patients vasomotor paralysis represents the predominant cause of mortality, death in pediatric sepsis is associated with severe hypovolemia and low cardiac output. The purpose of this article was to review the recent evidence on early treatment of pediatric severe sepsis and septic shock. Although current American College of Critical Care Medicine-Pediatric Advanced Life Support guidelines represent best practice, stronger evidences are lacking to confirm the components of these recommendations...
September 2010: Shock
https://www.readbyqxmd.com/read/20042260/fluid-overload-and-mortality-in-children-receiving-continuous-renal-replacement-therapy-the-prospective-pediatric-continuous-renal-replacement-therapy-registry
#15
MULTICENTER STUDY
Scott M Sutherland, Michael Zappitelli, Steven R Alexander, Annabelle N Chua, Patrick D Brophy, Timothy E Bunchman, Richard Hackbarth, Michael J G Somers, Michelle Baum, Jordan M Symons, Francisco X Flores, Mark Benfield, David Askenazi, Deepa Chand, James D Fortenberry, John D Mahan, Kevin McBryde, Douglas Blowey, Stuart L Goldstein
BACKGROUND: Critically ill children with hemodynamic instability and acute kidney injury often develop fluid overload. Continuous renal replacement therapy (CRRT) has emerged as a favored modality in the management of such children. This study investigated the association between fluid overload and mortality in children receiving CRRT. STUDY DESIGN: Prospective observational study. SETTING & PARTICIPANTS: 297 children from 13 centers across the United States participating in the Prospective Pediatric CRRT Registry...
February 2010: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/19325359/clinical-practice-parameters-for-hemodynamic-support-of-pediatric-and-neonatal-septic-shock-2007-update-from-the-american-college-of-critical-care-medicine
#16
Joe Brierley, Joseph A Carcillo, Karen Choong, Tim Cornell, Allan Decaen, Andreas Deymann, Allan Doctor, Alan Davis, John Duff, Marc-Andre Dugas, Alan Duncan, Barry Evans, Jonathan Feldman, Kathryn Felmet, Gene Fisher, Lorry Frankel, Howard Jeffries, Bruce Greenwald, Juan Gutierrez, Mark Hall, Yong Y Han, James Hanson, Jan Hazelzet, Lynn Hernan, Jane Kiff, Niranjan Kissoon, Alexander Kon, Jose Irazuzta, Jose Irazusta, John Lin, Angie Lorts, Michelle Mariscalco, Renuka Mehta, Simon Nadel, Trung Nguyen, Carol Nicholson, Mark Peters, Regina Okhuysen-Cawley, Tom Poulton, Monica Relves, Agustin Rodriguez, Ranna Rozenfeld, Eduardo Schnitzler, Tom Shanley, Saraswati Kache, Sara Skache, Peter Skippen, Adalberto Torres, Bettina von Dessauer, Jacki Weingarten, Timothy Yeh, Arno Zaritsky, Bonnie Stojadinovic, Jerry Zimmerman, Aaron Zuckerberg
BACKGROUND: The Institute of Medicine calls for the use of clinical guidelines and practice parameters to promote "best practices" and to improve patient outcomes. OBJECTIVE: 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock. PARTICIPANTS: Society of Critical Care Medicine members with special interest in neonatal and pediatric septic shock were identified from general solicitation at the Society of Critical Care Medicine Educational and Scientific Symposia (2001-2006)...
February 2009: Critical Care Medicine
https://www.readbyqxmd.com/read/18369591/accm-pals-haemodynamic-support-guidelines-for-paediatric-septic-shock-an-outcomes-comparison-with-and-without-monitoring-central-venous-oxygen-saturation
#17
RANDOMIZED CONTROLLED TRIAL
Cláudio F de Oliveira, Débora S F de Oliveira, Adriana F C Gottschald, Juliana D G Moura, Graziela A Costa, Andréa C Ventura, José Carlos Fernandes, Flávio A C Vaz, Joseph A Carcillo, Emanuel P Rivers, Eduardo J Troster
INTRODUCTION: The ACCM/PALS guidelines address early correction of paediatric septic shock using conventional measures. In the evolution of these recommendations, indirect measures of the balance between systemic oxygen delivery and demands using central venous or superior vena cava oxygen saturation (ScvO(2) > or = 70%) in a goal-directed approach have been added. However, while these additional goal-directed endpoints are based on evidence-based adult studies, the extrapolation to the paediatric patient remains unvalidated...
June 2008: Intensive Care Medicine
https://www.readbyqxmd.com/read/18158437/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2008
#18
R Phillip Dellinger, Mitchell M Levy, Jean M Carlet, Julian Bion, Margaret M Parker, Roman Jaeschke, Konrad Reinhart, Derek C Angus, Christian Brun-Buisson, Richard Beale, Thierry Calandra, Jean-Francois Dhainaut, Herwig Gerlach, Maurene Harvey, John J Marini, John Marshall, Marco Ranieri, Graham Ramsay, Jonathan Sevransky, B Taylor Thompson, Sean Townsend, Jeffrey S Vender, Janice L Zimmerman, Jean-Louis Vincent
OBJECTIVE: To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004. DESIGN: Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. This process was conducted independently of any industry funding...
January 2008: Critical Care Medicine
https://www.readbyqxmd.com/read/18058085/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2008
#19
R Phillip Dellinger, Mitchell M Levy, Jean M Carlet, Julian Bion, Margaret M Parker, Roman Jaeschke, Konrad Reinhart, Derek C Angus, Christian Brun-Buisson, Richard Beale, Thierry Calandra, Jean-Francois Dhainaut, Herwig Gerlach, Maurene Harvey, John J Marini, John Marshall, Marco Ranieri, Graham Ramsay, Jonathan Sevransky, B Taylor Thompson, Sean Townsend, Jeffrey S Vender, Janice L Zimmerman, Jean-Louis Vincent
OBJECTIVE: To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004. DESIGN: Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. This process was conducted independently of any industry funding...
January 2008: Intensive Care Medicine
https://www.readbyqxmd.com/read/17530137/pharmacologic-support-of-infants-and-children-in-septic-shock
#20
REVIEW
José Irazuzta, Kevin J Sullivan, Pedro Celiny R Garcia, Jefferson Pedro Piva
OBJECTIVES: Septic shock (SS) is a frequent cause for admission to the pediatric intensive care unit, requiring prompt recognition and intervention to improve outcome. Our aim is to review the relevant literature related to the diagnosis and management of SS and present a sequential management for its treatment. SOURCES: Non-systematic review of medical literature using the MEDLINE database. Articles were selected according to their relevance to the objective and according to the authors' opinions...
May 2007: Jornal de Pediatria
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