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https://www.readbyqxmd.com/read/29142478/chronic-opioids-in-gastroparesis-relationship-with-gastrointestinal-symptoms-healthcare-utilization-and-employment
#1
Asad Jehangir, Henry P Parkman
AIM: To examine the relationship of chronic scheduled opioid use on symptoms, healthcare utilization and employment in gastroparesis (Gp) patients. METHODS: Patients referred to our tertiary care academic center from May 2016 to July 2017, with established diagnosis or symptoms suggestive of Gp filled out the Patient Assessment of Upper GI Symptoms, abdominal pain and demographics questionnaires, and underwent gastric emptying and blood tests. They were asked about taking pain medicines and the types, doses, and duration...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29136090/perfect-for-a-gin-and-tonic-how-context-drives-consumption-within-a-modified-bogus-taste-test
#2
Rebecca L Monk, Adam W Qureshi, Adam McNeill, Marianne Erskine-Shaw, Derek Heim
Aim: To implement a modified bogus taste test (BTT) and to examine the interactive effects of environmental and social contexts on levels of 'alcohol' consumption. Method: University students (Study 1 n = 38, Study 2 n = 80), recruited via opportunity sampling, completed a modified BTT under the pretence of assessing garnish preference for gin and tonic. All participants were tested alone or as part of an existing friendship group. In Study 1 participants were in a laboratory setting but were exposed to different contextual cues (alcohol-related or neutral) by way of posters displayed on the walls...
November 9, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29133390/recovery-of-taste-organs-and-sensory-function-after-severe-loss-from-hedgehog-smoothened-inhibition-with-cancer-drug-sonidegib
#3
Archana Kumari, Alexandre N Ermilov, Marina Grachtchouk, Andrzej A Dlugosz, Benjamin L Allen, Robert M Bradley, Charlotte M Mistretta
Striking taste disturbances are reported in cancer patients treated with Hedgehog (HH)-pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector Smoothened (SMO). We tested the potential for molecular, cellular, and functional recovery in mice from the severe disruption of taste-organ biology and taste sensation that follows HH/SMO signaling inhibition. Sonidegib treatment led to rapid loss of taste buds (TB) in both fungiform and circumvallate papillae, including disruption of TB progenitor-cell proliferation and differentiation...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29130554/sensory-recovery-of-myomucosal-flap-oral-cavity-reconstructions
#4
Olindo Massarelli, Luigi Angelo Vaira, Andrea Biglio, Roberta Gobbi, Giovanni Dell'aversana Orabona, Giacomo De Riu
BACKGROUND: Sensory restoration of the oral cavity is a primary aim of reconstructive surgery in posttraumatic or postablative defects. Sensitivity plays a key role in oral function, whose impairment strongly affects the patient's quality of life. Cheek myomucosal flaps provide a reliable and tissue-like reconstruction of these regions but their sensitive recovery, which we still know little about, deserves thorough assessment. METHODS: In this retrospective study, the myomucosal cheek flaps were tested for different aspects of sensory recovery: touch; 2-point discrimination; pain; sharp/smooth discrimination; ability to feel hot/cold stimulus; stereognosis; and taste...
November 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29128987/comparison-of-olfactory-and-gustatory-disorders-in-alzheimer-s-disease
#5
Minoru Kouzuki, Tetsuya Suzuki, Masaya Nagano, Syouta Nakamura, Yuto Katsumata, Ayumi Takamura, Katsuya Urakami
Patients with Alzheimer's disease (AD) develop olfactory and gustatory disorders. However, the order of failure and relevance of the pathophysiology are unclear. We compared olfactory identification and whole mouth gustation in patients with AD to those with mild cognitive impairment (MCI) and to healthy controls (HC) and assessed correlations with pathophysiology. Patients with AD (n = 40), MCI (n = 34), and HC (n = 40) were recruited. We performed the Odor Stick Identification Test for Japanese (OSIT-J), gustatory test by the intraoral dropping method using taste solutions, Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale-cognitive subscale Japanese version (ADAS-J cog), Touch Panel-type Dementia Assessment Scale (TDAS), and measurement of amyloid β (Aβ) 42 and phosphorylated tau (p-tau) 181 levels in cerebrospinal fluid (CSF)...
November 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29127026/resource-forecasting-differential-effects-of-glucose-taste-and-ingestion-on-delay-discounting-and-self-control
#6
X T Wang, Ryan N Reed, Lee A Baugh, Kelene A Fercho
We tested a novel hypothesis that glucose taste acts as a signal for resource acquisition, motivating preference for immediate rewards while actual glucose ingestion prompts resource conservation, promoting future-orientated self-regulation. In Study 1, participants were engaged in a delay-discounting task and a grip-control task before and after a beverage intervention (glucose drink, water drink, or glucose mouth-rinse). Glucose ingestion decreased delay discounting, making larger-and-later rewards more attractive...
November 7, 2017: Appetite
https://www.readbyqxmd.com/read/29121436/association-of-dental-and-maxillary-sinus-pathologies-with-ear-nose-and-throat-symptoms
#7
Rachel Horwitz Berkun, David Polak, Lior Shapira, Ron Eliashar
OBJECTIVES: To investigate the correlation between cone beam computerized tomography (CBCT) findings in the maxillary sinus, Ear-Nose-Throat (ENT) symptoms and dental pathologies in asymptomatic patients. MATERIALS AND METHODS: A total 81 patients were referred for CBCT and filled a standard ENT visual analog scale (VAS) questionnaire. CBCT images were analyzed for sinus ostium obstruction, Schneiderian membrane thickening, sinus floor turbidity and the presence of polyps...
November 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29121087/the-gram-negative-sensing-receptor-pgrp-lc-contributes-to-grooming-induction-in-drosophila
#8
Aya Yanagawa, Claudine Neyen, Bruno Lemaitre, Frédéric Marion-Poll
Behavioral resistance protects insects from microbial infection. However, signals inducing insect hygiene behavior are still relatively unexplored. Our previous study demonstrated that olfactory signals from microbes enhance insect hygiene behavior, and gustatory signals even induce the behavior. In this paper, we postulated a cross-talk between behavioral resistance and innate immunity. To examine this hypothesis, we employed a previously validated behavioral test to examine the function of taste signals in inducing a grooming reflex in decapitated flies...
2017: PloS One
https://www.readbyqxmd.com/read/29119724/evaluation-of-first-line-bismuth-containing-7-day-concomitant-quintuple-therapy-for-helicobacter-pylori-eradication
#9
Jianfang Ye, Junbo Hong, Yin Zhu, Yong Xie, Xu Shu, Lingyu Luo, Chuan Xie, Zhenhua Zhu, Nonghua Lu
BACKGROUND: Helicobacter pylori infection is difficult to cure, mainly due to antibiotic resistance. We performed a trial to determine the efficacy and safety of a bismuth-containing 7-day concomitant quintuple regimen for the eradication of H. pylori. METHODS: Conducted from August 2015 to February 2016 at First Affiliated Hospital of Nanchang University, this prospective trial enrolled 70 untreated H. pylori-positive patients. Patients received 7-day quintuple therapy consisting of bismuth subcitrate 220 mg, esomeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1 g, and metronidazole 400 mg, each twice daily...
November 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29111088/state-laws-are-associated-with-school-lunch-duration-and-promotion-practices
#10
Lindsey Turner, Julien Leider, Elizabeth Piekarz-Porter, Marlene B Schwartz, Caitlin Merlo, Nancy Brener, Jamie F Chriqui
BACKGROUND: The changes in school meal programs stemming from the Healthy, Hunger-Free Kids Act of 2010 have expanded interest in strategies that increase student participation in school lunch and reduce plate waste. However, it remains unclear what factors are associated with schools' use of such strategies. OBJECTIVE: This study examines whether state laws are associated with two types of school meal-related practices: (a) using promotional strategies (ie, taste tests, using posters or announcements) and (b) duration of lunch periods...
October 27, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29110749/salivary-leptin-and-tas1r2-tas1r3-polymorphisms-are-related-to-sweet-taste-sensitivity-and-carbohydrate-intake-from-a-buffet-meal-in-healthy-young-adults
#11
Pengfei Han, Russell S J Keast, Eugeni Roura
The influence of sweet taste sensitivity on food intake is not well understood. We investigated the involvement of salivary leptin and SNP of the sweet taste receptor genes (TAS1R2/TAS1R3) on sweet taste sensitivity, sensory-specific satiety (SSS) and macronutrient intake in healthy human adults. In all, nineteen high sweet sensitivity (HS) and eleven low sweet sensitivity (LS) subjects were classified based on the sweetness perception of one solution (9 mm sucrose) forced-choice triangle test. All participants completed a randomised crossover design experiment where they consumed one of three iso-energetic soup preloads differing in primary taste quality (sweet, non-sweet taste-control or no-taste energy-control)...
November 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29109313/evaluation-of-the-antifungal-effect-of-chicory-extracts-on-candida-glabrata-and-candida-krusei-in-a-laboratory-environment
#12
Hosein Eslami, Hossein Babaei, Parisa Falsafi, Mahdi Rahbar, Fereshteh Najar-Karimi, Solmaz Pourzare-Mehrbani
AIM: This research has evaluated the extract's antifungal effects on Candida glabrata and Candida krusei in a laboratory environment. MATERIALS AND METHODS: In this research, to evaluate the antifungal effect and the minimal inhibitory concentration (MIC) determination of chicory extract, the Clinical and Laboratory Standards Institute (CLSI) was used. Candida glabrata and C. krusei funguses were procured from the Tehran Pasteur Institute; they were grown in the relative growing environment according to the required conditions...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29108962/no-detriment-in-taste-response-or-expression-in-offspring-of-mice-fed-representative-levels-of-sucrose-or-non-caloric-sucralose-while-pregnant
#13
Ezen Choo, Robin Dando
Recent studies in mice indicate that consumption of acesulfame K (a high intensity sweetener) while pregnant, can lead to deficits in taste or enhanced sweet consumption in the offspring, leading to concerns the same may be common in human populations. However, this work employed a relatively unpopular sweetener, fed in quantities amounting to over 20× the FDA's Acceptable Daily Intake (ADI). The aims of this study were to test the effects of sucralose, the USA's most popular high intensity sweetener, along with sucrose, on the taste system of the offspring of mice supplemented at a level commensurate with ADIs while pregnant...
November 3, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29108741/the-role-of-smell-taste-flavour-and-texture-cues-in-the-identification-of-vegetables
#14
V L van Stokkom, A E Blok, O van Kooten, C de Graaf, M Stieger
It has been shown that the identification of many foods including vegetables based on flavour cues is often difficult. The effect of providing texture cues in addition to flavour cues on the identification of foods and the effect of providing taste cues only on the identification of foods have not been studied. The aim of this study was to assess the role of smell, taste, flavour and texture cues in the identification of ten vegetables commonly consumed in The Netherlands (broccoli, cauliflower, French bean, leek, bell pepper, carrot, cucumber, iceberg lettuce, onion and tomato)...
November 8, 2017: Appetite
https://www.readbyqxmd.com/read/29107810/seco-dammarane-triterpenoids-from-the-leaves-of-cyclocarya-paliurus
#15
Yan-Jiao Chen, Liang Na, Jialong Fan, Jianping Zhao, Nusrat Hussain, Yu-Qing Jian, Hanwen Yuan, Bin Li, Bin Liu, M Iqbal Choudhary, Ikhlas Khan, Wei Wang
The leaves of Cyclocarya paliurus with sweet taste are often used as herbal tea in People's Republic of China. In this study eight previously undescribed seco-dammarane type triterpenoids, cyclocariols A-H along with seven known compounds were isolated and characterized from its leaves. A possible biogenetic pathway for seco-dammarane type triterpenoids formation has been discussed. Cyclocariols A-H were evaluated for their cytotoxicities against human liver (SMMC-7721) and breast cancer (BT-549) cell lines...
November 3, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29107768/copycat-snacks-can-students-differentiate-between-school-and-store-snacks
#16
Georgianna Mann
In 2014, the national Smart Snacks in School nutrition standards placed regulations on all snack foods sold in schools. Many food companies reformulated common snack food products for sale in schools, called "copycat snacks", which look similar to nutritionally different foods sold in stores. It is possible that these snacks create consumer confusion among students. The purpose of this study was to determine if middle school students could differentiate, in taste and appearance, between school (copycat) and store versions of common snacks...
October 28, 2017: Appetite
https://www.readbyqxmd.com/read/29104366/characterizing-dynamic-sensory-properties-of-nutritive-and-nonnutritive-sweeteners-with-temporal-check-all-that-apply
#17
M Michelle Reyes, John C Castura, John E Hayes
Temporal Check-All-That-Apply (TCATA) is a rapid method where attributes are actively checked and unchecked to track sensations over time, so that the checked words fully describe the sample in any given moment. Here, we characterize the temporal profiles of sweeteners using TCATA. In two experiments, sweeteners were tested in water at concentrations known to elicit weak to moderate sweetness. Before evaluating the sweeteners, participants (n= ~125 per experiment) were familiarized with the TCATA method with a guided example using imaginary samples of Kool-Aid...
June 2017: Journal of Sensory Studies
https://www.readbyqxmd.com/read/29104107/preference-for-tap-bottled-and-recycled-water-relations-to-ptc-taste-sensitivity-and-personality
#18
Daniel Harmon, Mary Gauvain, Z Reisz, Isaac Arthur, S Drew Story
This study investigated people's preferences for different water sources and factors that predict such preferences using a blind taste test. Water preferences of 143 participants for one name-brand bottled water, one groundwater-sourced tap water, and one indirect potable reuse (IDR) water were assessed. For predictors of water preference, we measured each participant's PTC taste sensitivity and assessed two personality traits (Neuroticism, Openness to Experience). We also explored participants' descriptions of each water source...
November 2, 2017: Appetite
https://www.readbyqxmd.com/read/29103353/cyclodextrin-based-oral-dissolving-films-formulation-of-taste-masked-meloxicam
#19
Wipada Samprasit, Prasert Akkaramongkolporn, Ruchadaporn Kaomongkolgit, Praneet Opanasopit
This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems (dimethylformamide (DMF) and ethyl alcohol (EtOH)) was performed. Prepared films were evaluated for morphology, physical and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers...
November 6, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29099864/assessing-olfactory-functions-in-patients-with-barth-syndrome
#20
Michele Dibattista, Simona Lobasso, Sebastiano Stramaglia, Angela Corcelli
Barth syndrome is a rare X-linked disease affecting less than 200 individuals worldwide. Several comorbidities have been associated with the pathology and, among those, cardiac myopathy and neutropenia are the most life threatening. The appropriate nutritive support is important to sustain the everyday life of Barth syndrome patients given the chronic fatigue they experience. Since they often prefer salty and fried food, and avoid vegetables and fruits, their eating habit and food preferences do not always provide the proper amount of vitamins and amino acids...
2017: PloS One
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