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https://www.readbyqxmd.com/read/28214382/allergic-contact-cheilitis-from-anethole-containing-toothpastes-a-practical-solution
#1
N Horst, J Leysen, T Mellaerts, J Lambert, O Aerts
In patients presenting with therapy-resistant cheilitis, especially when extending to the perioral skin, patch tests should be performed, even in longstanding cases(1-2) . A 55-year-old woman suffered from an oozing cheilitis for three months with erythema, edema and crusting of the lips and perioral skin (Fig. 1). An intra-oral burning sensation, loss of taste and a dry mouth were also present. Microbiological swabs and a blood analysis did not reveal any abnormalities, and the application of topical corticosteroids brought only temporary relief...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28188907/safety-pharmacokinetic-and-pharmacodynamic-study-in-healthy-subjects-of-oral-neo6860-a-modality-selective-trpv1-antagonist
#2
William Brown, Richard L Leff, Andrew Griffin, Stuart Hossack, Roxane Aubray, Philippe Walker, Dan A Chiche
: Most previous TRPV1 antagonist programs have been put on hold, mainly due on-target adverse events: hyperthermia and impaired noxious heat sensation. NEO6860 is a TRPV1 antagonist, blocking capsaicin activation of the target, with little or no effect against pH or heat activation. The hypothesis is that this pharmacological profile will translate into analgesia without undesired effects on the body temperature or heat-pain threshold. This phase I, double blind, placebo controlled, ascending dose study, included 64 subjects...
February 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28115648/drug-induced-taste-disorders-in-clinical-practice-and-preclinical-safety-evaluation
#3
Tao Wang, John Glendinning, Miriam Grushka, Thomas Hummel, Keith Mansfield
More than 200 medications can induce taste disorders in patients. They not only reduce quality of life for those affected, but can lead to malnutrition, severe dehydration and difficulty in maintaining a therapeutic regimen. Nevertheless, the impact of drug candidates on taste is rarely evaluated in preclinical toxicology studies during the early stage of drug development. Moreover, knowledge about how to investigate these adverse effect is scarce in the toxicology field. Here, we discuss the clinical status of drug-induced taste disorders in patients, with the goal of providing toxicologists with a broad understanding its prevalence, and how stressful and even dangerous it can be to affected patients...
January 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28100279/severe-community-acquired-adenovirus-pneumonia-treated-with-oral-ribavirin-a-case-report
#4
Byung Woo Yoon, Yong Geon Song, Seung Hyeun Lee
BACKGROUND: Adenovirus is a common pathogen of acute upper respiratory infection in children and is generally self-limiting. Severe adenovirus infections have been reported in immunocompromised hosts especially bone marrow transplantation recipients due to hematologic malignancy. Severe adenovirus pneumonia in immunocompetent hosts has rarely been reported and optimal treatment has not been established. We report a case of community-acquired severe adenovirus pneumonia which was successfully treated with early administration of oral ribavirin...
January 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28081044/evaluation-of-the-condom-barriers-scale-for-young-black-men-who-have-sex-with-men-reliability-and-validity-of-3-subscales
#5
Richard A Crosby, Stephanie A Sanders, Cynthia A Graham, Robin Milhausen, William L Yarber, Leandro Mena
BACKGROUND: Reliable and valid scale measures of barriers to condom use are not available for young black men who have sex with men (YBMSM). The purpose of this study was to evaluate the Condom Barriers Scales for application with YBMSM. METHODS: A clinic-based sample of 600 YBMSM completed a computer-assisted self-interview. The primary measure was a 14-item abbreviated version of the Condom Barriers Scale. Reliability and criterion validity were assessed. RESULTS: All 3 subscales were reliable: partner-related barriers (Cronbach α=0...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28075495/oral-tactile-sensitivity-and-masticatory-performance-are-impaired-in-stroke-patients
#6
M Schimmel, G Voegeli, E Duvernay, B Leemann, F Müller
Oro-facial impairment following stroke frequently involves reduced chewing performance, that is oral phase dysphagia. The aim was to investigate the sensitivity of oral tissues following stroke and its potential impact on masticatory function. Therefore, hospitalised post-stroke patients were recruited and compared to healthy controls. Outcome measures comprised masticatory performance employing a colour-mixing ability, that is a bolus-kneading test, maximum lip- and bite force and the one-point and two-point tactile thresholds...
March 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28005741/two-thirds-lip-defects-a-new-combined-reconstructive-technique-for-patients-with-epithelial-cancer
#7
Tiziana Vitagliano, Lucia Stella Curto, Antonio Greto Ciriaco, Pietro Gareri, Diego Ribuffo, Manfredi Greco
BACKGROUND: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and adipose tissue transplant. METHODS: The study was lead in the Plastic and Reconstructive Surgery Department of the University of Catanzaro...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27965488/rebamipide-to-manage-stomatopyrosis-in-oral-submucous-fibrosis
#8
Joanna Baptist, Shrijana Shakya, Ravikiran Ongole
INTRODUCTION: Oral submucous fibrosis (OSF) causes progressive debilitating symptoms, such as oral burning sensation (stomatopyrosis) and limited mouth opening. The standard of care (SOC) protocol includes habit cessation, intralesional steroid and hyaluronidase injections, and mouth opening exercises. The objective of the study was to evaluate efficacy of rebamipide in alleviating burning sensation of the oral mucosa in OSF in comparison with SOC intralesional steroid injections. MATERIALS AND METHODS: Twenty OSF patients were divided into two groups [rebamipide (100 mg TID for 21 days) and betamethasone (4 mg/mL biweekly for 4 weeks)] of 10 each by random sampling...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27891461/comparison-of-therapeutic-efficacy-of-placental-extract-with-dexamethasone-and-hyaluronic-acid-with-dexamethasone-for-oral-submucous-fibrosis-a-retrospective-analysis
#9
Palak Hasmukhbhai Shah, Rashmi Venkatesh, Chandramani Bhagawan More, Vaishnavee Vassandacoumara
INTRODUCTION: Oral Submucous Fibrosis (OSMF) is a potentially malignant disease of the oral cavity associated with betel nut chewing. The management of OSMF has been a subject of controversy and no definitive and widely accepted treatment is currently available for this condition. AIM: To retrospectively evaluate the therapeutic efficacy of two treatment regimens (placental extract with dexamethasone and hyaluronic acid with dexamethasone) for the treatment of OSMF...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27818698/relationship-of-the-cold-heat-sensation-of-the-limbs-and-abdomen-with-physiological-biomarkers
#10
Duong Duc Pham, JeongHoon Lee, GaYul Kim, JiYeon Song, JiEun Kim, Chae Hun Leem
The present study explored the relationship between the regional Cold-Heat sensation, the key indicator of the Cold-Heat patterns in traditional East Asian medicine (TEAM), and various biomarkers in Korean population. 734 apparently healthy volunteers aged 20 years and older were enrolled. Three scale self-report questions on the general thermal feel in hands, legs, and abdomen were examined. We found that 65% of women tended to perceive their body, particularly their hands and legs, to be cold, versus 25% of men...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27747728/colchicine-induced-acute-neuromyopathy-in-a-patient-using-concomitant-fluconazole-case-report-and-literature-review
#11
Yi-Chia Su, Chih-Chien Wu
A 54-year-old woman presented at the emergency department after experiencing lower limb weakness and bilateral ankle pain for 2 days. She had a history of type 2 diabetes mellitus, diabetes mellitus nephropathy with chronic kidney disease, and chronic gouty arthritis. She had received 0.6 mg colchicine orally once or twice daily for 8 months. Four days prior to her emergency department visit, she was discharged from our nephrology ward, where she had been admitted because of a urinary tract infection. During hospitalization, she was treated with intravenous cefazolin for 7 days...
December 2015: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27720650/clinicobiochemical-evaluation-of-turmeric-with-black-pepper-and-nigella-sativa-in-management-of-oral-submucous-fibrosis-a-double-blind-randomized-preliminary-study
#12
Pratik R Pipalia, Rajeshwari G Annigeri, Ranjeeta Mehta
OBJECTIVE: To investigate the effectiveness of turmeric with black pepper and nigella sativa in oral submucous fibrosis (OSMF). STUDY DESIGN: Forty OSMF patients were randomly divided into two groups. The study was performed under a double-blind, randomized design. Group A received turmeric with black pepper and group B received nigella sativa for 3 months. Clinical evaluation was done every 15 days. Patients' serum superoxide dismutase (SOD) levels were assessed before and after treatment and also compared with healthy controls...
December 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27684535/sensory-topography-of-oral-structures
#13
Shethal Bearelly, Steven W Cheung
Importance: Sensory function in the oral cavity and oropharynx is integral to effective deglutition and speech production. The main hurdle to evaluation of tactile consequences of upper aerodigestive tract diseases and treatments is access to a reliable clinical tool. We propose a rapid and reliable procedure to determine tactile thresholds using buckling monofilaments to advance care. Objective: To develop novel sensory testing monofilaments and map tactile thresholds of oral cavity and oropharyngeal structures...
January 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27669725/comparison-of-self-perceived-oral-symptoms-and-periodontal-parameters-among-habitual-%C3%A2-shamma-chewers-gutka-chewers-and-non-chewers
#14
Mansour Al-Askar, Tariq Abduljabbar, Fahim Vohra, Sandeep Pasumarthy, Elham Gholamiazizi, Michael Yunker, Georgios E Romanos, Fawad Javed
OBJECTIVE: There are no studies that have (a) compared self-perceived oral symptoms and clinical and radiographic periodontal parameters (plaque index [PI], bleeding on probing [BoP], clinical attachment loss [CAL], and marginal bone loss [MBL]) among shamma-chewers (SC) and gutka-chewers (GC); and (b) assessed periodontal parameters among SC. The aim of the present study was to compare the self-perceived oral symptoms and periodontal parameters among SC, GC, and controls. METHOD AND MATERIALS: Information regarding demographic characteristics and self-perceived oral symptoms was gathered using a structured questionnaire...
September 26, 2016: Quintessence International
https://www.readbyqxmd.com/read/27665986/oral-leukoplakia-associated-with-amalgam-restorations
#15
Zeynep B Gönen, Canay Yılmaz Asan, Osman Etöz, Alper Alkan
The World Health Organization has defined oral leukoplakia (OL) as "a white patch or plaque of the oral mucosa that cannot be characterized clinically or pathologically as any other disease". A 21-year-old male with OL presented with a bilateral burning sensation in the buccal mucosa. The patient had amalgam restorations, and an epicutaneous patch test indicated a positive response to amalgam. The amalgam restorations were therefore removed and the cavities were refilled with a composite resin restorative material...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27617821/two-thirds-lip-defects-a-new-combined-reconstructive-technique-for-patients-with-epithelial-cancer
#16
Tiziana Vitagliano, Lucia Stella Curto, Antonio Greto Ciriaco, Pietro Gareri, Diego Ribuffo, Manfredi Greco
BACKGROUND: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and adipose tissue transplant. METHODS: The study was lead in the Plastic and Reconstructive Surgery Department of the University of Catanzaro...
September 9, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27533628/case-study-gluteal-compartment-syndrome-as-a-cause-of-lumbosacral-radiculoplexopathy-and-complex-regional-pain-syndrome
#17
Andrew Lederman, David Turk, Antonio Howard, Srinivas Reddy, Michelle Stern
We present the case of a 24 yr old male who was diagnosed with gluteal compartment syndrome and was subsequently found to have developed lumbosacral radiculoplexopathy and complex regional pain syndrome. The patient's gluteal compartment syndrome was diagnosed within 24 h of presentation to the emergency room, and he underwent emergent compartment release. While recovering postoperatively, persistent weakness was noted in the right lower limb. Results of electrodiagnostic testing were consistent with a lumbosacral radiculoplexopathy...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27513396/the-effects-of-conscious-sedation-with-nitrous-oxide-oxygen-on-cognitive-functions
#18
Sara Samur Ergüven, Ertan Ali Delilbaşi, Berrin İşik, Ferhunde Öktem
BACKGROUND/AIM: The aim of this study was to investigate the effects of conscious sedation with 40% nitrous oxide/oxygen (N2O/O2) on cognitive functions. MATERIALS AND METHODS: Forty dental patients referred to the sedation unit at Gazi University Faculty of Dentistry Department of Oral and Maxillofacial Surgery received a combination of 40% N2O/O2 inhalation for conscious sedation. Psychometric tests were applied three times: before sedation, during sedation, and at the end of the recovery, for assessing cognitive functions...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27511471/oral-sensory-nerve-damage-causes-and-consequences
#19
REVIEW
Derek J Snyder, Linda M Bartoshuk
Oral sensations (i.e., taste, oral somatosensation, retronasal olfaction) are integrated into a composite sense of flavor, which guides dietary choices with long-term health impact. The nerves carrying this input are vulnerable to peripheral damage from multiple sources (e.g., otitis media, tonsillectomy, head injury), and this regional damage can boost sensations elsewhere in the mouth because of central interactions among nerve targets. Mutual inhibition governs this compensatory process, but individual differences lead to variation in whole-mouth outcomes: some individuals are unaffected, others experience severe loss, and some encounter sensory increases that may (if experienced early in life) elevate sweet-fat palatability and body mass...
June 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27504419/evaluation-of-antifungal-efficacy-of-ethanolic-crude-lawsone-and-listerine-mouthwash-in-uncontrolled-diabetics-and-denture-wearers-a-randomized-clinical-trial
#20
Bhavana Sujanamulk, Rajalakshmi Chintamaneni, Anuradha Chennupati, Prashant Nahar, Rattaiah Setty Chaluvadi, Ramakrishna Vemugunta, Meka Venkata Poorna Prabhat
INTRODUCTION: Lawsonia Inermis (LI) is a shrub cultivated throughout India. Many in vitro studies have been done on antifungal activity of LI, although none of the studies have been conducted invivo. AIM: To evaluate the antifungal efficacy of ethanolic extract of crude lawsone in comparison with listerine mouth wash in known diabetics and wearing dentures. MATERIALS AND METHODS: A total of 60 subjects were taken and randomly divided into two groups of 30 each...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
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