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https://www.readbyqxmd.com/read/28286285/minocycline-reduces-mechanical-allodynia-and-depressive-like-behaviour-in-type-1-diabetes-mellitus-in-the-rat
#1
Diana Amorim, Sónia Puga, Rui Bragança, António Braga, Antti Pertovaara, Armando Almeida, Filipa Pinto-Ribeiro
A common and devastating complication of diabetes mellitus is painful diabetic neuropathy (PDN) that can be accompanied by emotional disorders such as depression. A few studies have suggested that minocycline that inhibits microglia may attenuate pain hypersensitivity in PDN. Moreover, a recent study reported that minocycline has an acute antidepressive-like effect in diabetic animals. Here we studied whether (i) prolonged minocycline treatment suppresses pain behaviour in PDN, (ii) the minocycline effect varies with submodality of pain, and (iii) the suppression of pain behaviour by prolonged minocycline treatment is associated with antidepressive-like effect...
March 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28271438/short-term-follow-up-of-masticatory-adaptation-after-rehabilitation-with-an-immediately-loaded-implant-supported-prosthesis-a-pilot-assessment
#2
Mihoko Tanaka, Collaert Bruno, Reinhilde Jacobs, Tetsurou Torisu, Hiroshi Murata
BACKGROUND: When teeth are extracted, sensory function is decreased by a loss of periodontal ligament receptions. When replacing teeth by oral implants, one hopes to restore the sensory feedback pathway as such to allow for physiological implant integration and optimized oral function with implant-supported prostheses. What remains to be investigated is how to adapt to different oral rehabilitations. The purpose of this pilot study was to assess four aspects of masticatory adaptation after rehabilitation with an immediately loaded implant-supported prosthesis and to observe how each aspect will recover respectively...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28215812/indoor-air-pollutants-ventilation-rate-determinants-and-potential-control-strategies-in-chinese-dwellings-a-literature-review
#3
Wei Ye, Xu Zhang, Jun Gao, Guangyu Cao, Xiang Zhou, Xing Su
After nearly twenty years of rapid modernization and urbanization in China, huge achievements have transformed the daily lives of the Chinese people. However, unprecedented environmental consequences in both indoor and outdoor environments have accompanied this progress and have triggered public awareness and demands for improved living standards, especially in residential environments. Indoor pollution data measured for >7000 dwellings (approximately 1/3 were newly decorated and were tested for volatile organic compound (VOC) measurements, while the rest were tested for particles, phthalates and other semi-volatile organic compounds (SVOCs), moisture/mold, inorganic gases and radon) in China within the last ten years were reviewed, summarized and compared with indoor concentration recommendations based on sensory or health end-points...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28203479/metformin-impairs-spatial-memory-and-visual-acuity-in-old-male-mice
#4
Nopporn Thangthaeng, Margaret Rutledge, Jessica M Wong, Philip H Vann, Michael J Forster, Nathalie Sumien
Metformin is an oral anti-diabetic used as first-line therapy for type 2 diabetes. Because benefits of metformin extend beyond diabetes to other age-related pathology, and because its effect on gene expression profiles resembles that of caloric restriction, metformin has a potential as an anti-aging intervention and may soon be assessed as an intervention to extend healthspan. However, beneficial actions of metformin in the central nervous system have not been clearly established. The current study examined the effect of chronic oral metformin treatment on motor and cognitive function when initiated in young, middle-aged, or old male mice...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28190463/prophylactic-topical-paeoniflorin-prevents-mechanical-allodynia-caused-by-paclitaxel-in-mice-through-adenosine-a1-receptors
#5
Tsugunobu Andoh, Nao Kobayashi, Daisuke Uta, Yasushi Kuraishi
BACKGROUND: The chemotherapeutic agent paclitaxel (PTX) causes refractory peripheral neuropathy as a side effect. Prophylactic oral administration of the traditional herbal medicine Shakuyakukanzoto containing Paeoniae Radix and Glycyrrhizae Radix prevents the development of PTX-induced mechanical allodynia in mice via peripheral effects, mostly due to Paeoniae Radix. However, the bioactive component responsible for the prevention of PTX-induced neuropathic pain remains unknown. PURPOSE: To determine whether a monoterpene glycoside paeoniflorin (PF), which is the principal bioactive constituent of Paeoniae Radix, has inhibitory effects on PTX-induced mechanical allodynia and investigate the underlying mechanisms...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28166091/oral-polyphosphate-suppresses-bacterial-collagenase-production-and-prevents-anastomotic-leak-due-to-serratia-marcescens-and-pseudomonas-aeruginosa
#6
Sanjiv K Hyoju, Robin E Klabbers, Melissa Aaron, Monika A Krezalek, Alexander Zaborin, Mara Wiegerinck, Neil H Hyman, Olga Zaborina, Harry Van Goor, John C Alverdy
OBJECTIVE: The objective of this study was to determine the effect of polyphosphate on intestinal bacterial collagenase production and anastomotic leak in mice undergoing colon surgery. BACKGROUND: We have previously shown that anastomotic leak can be caused by intestinal pathogens that produce collagenase. Because bacteria harbor sensory systems to detect the extracellular concentration of phosphate which controls their virulence, we tested whether local phosphate administration in the form of polyphosphate could attenuate pathogen virulence and prevent leak without affecting bacterial growth...
February 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/27845440/odour-induced-analgesia-mediated-by-hypothalamic-orexin-neurons-in-mice
#7
Shogo Tashiro, Ran Yamaguchi, Sodemi Ishikawa, Takeshi Sakurai, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani
Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds mediated by olfaction have not been thoroughly examined. We performed behavioural pain tests under odourant vapour exposure in mice. Among six odourant molecules examined, linalool significantly increased the pain threshold and attenuated pain behaviours...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27827953/blocking-trpa1-in-respiratory-disorders-does-it-hold-a-promise
#8
REVIEW
Indranil Mukhopadhyay, Abhay Kulkarni, Neelima Khairatkar-Joshi
Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is expressed abundantly on the C fibers that innervate almost entire respiratory tract starting from oral cavity and oropharynx, conducting airways in the trachea, bronchi, terminal bronchioles, respiratory bronchioles and upto alveolar ducts and alveoli. Functional presence of TRPA1 on non-neuronal cells got recognized recently. TRPA1 plays a well-recognized role of "chemosensor", detecting presence of exogenous irritants and endogenous pro-inflammatory mediators that are implicated in airway inflammation and sensory symptoms like chronic cough, asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis and cystic fibrosis...
November 5, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27815794/dental-health-and-odontogenic-infections-among-6-to-16-year-old-german-students-with-special-health-care-needs-shcn
#9
Marco Dziwak, Roswitha Heinrich-Weltzien, Kathrin Limberger, Susanne Ifland, Ilka Gottstein, Thomas Lehmann, Ina M Schüler
OBJECTIVES: This cross-sectional study aimed to assess dental health and odontogenic infections in students with special health care needs (SHCN) in the Free State of Thuringia, Germany. METHODS: From 1283 students with SHCN aged 6-16 years, 66.0 % (n = 848 of whom are 35.7 % females and 64.3 % males) with intellectual/learning disabilities (ID/LD), physical disabilities (PD), and sensory disorders (SD) participated after informed consent in oral examinations according to WHO standards...
November 5, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27792799/characterization-of-burning-mouth-syndrome-in-patients-with-parkinson-s-disease
#10
David Bonenfant, Pierre H Rompré, Nathalie Rei, Nicolas Jodoin, Valerie Lynn Soland, Veronica Rey, Christine Brefel-Courbon, Fabienne Ory-Magne, Olivier Rascol, Pierre J Blanchet
AIMS: To determine the prevalence and characteristics of burning mouth syndrome (BMS) in a Parkinson's disease (PD) population through a self-administered, custom-made survey. METHODS: A total of 218 surveys were collected during regular outpatient visits at two Movement Disorders Clinics in Montreal (Canada) and Toulouse (France) to gather information about pain experience, PD-related symptoms, and oral and general health. A neurologist confirmed the diagnosis of PD, drug treatment, Hoehn-Yahr stage, and Schwab & England Activity of Daily Living score...
October 2016: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/27771455/enhanced-axonal-regeneration-of-the-injured-sciatic-nerve-by-administration-of-buyang-huanwu-decoction
#11
In Ae Chang, Hee Don Lim, Ki Joong Kim, Hwachul Shin, Uk Namgung
ETHNOPHARMACOLOGICAL RELEVANCE: Buyang Huanwu decoction (BYHWD) has been used in the traditional Chinese medicine for the treatment of cardiovascular and neurological symptoms, and recent experimental studies have begun to provide evidence showing its protective effects on neural cells. Yet, its function for the regenerative responses of axons in the peripheral nerve after injury is not known. AIM OF THE STUDY: The primary objective of the present study was to explore that BYHWD is involved in growth-promoting activity of the peripheral nerve axons after injury...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27770785/bogijetong-decoction-and-its-active-herbal-components-protect-the-peripheral-nerve-from-damage-caused-by-taxol-or-nerve-crush
#12
So Hyun Ahn, In Ae Chang, Ki-Joong Kim, Chul-Jung Kim, Uk Namgung, Chung-Sik Cho
BACKGROUND: Bogijetong decoction (BGJTD) is a herbal drug formulation used in the traditional Asian medicine to treat neuropathic insults associated with diabetes and anticancer therapy. To understand the biological basis of BGJTD on protective effects against neuropathy, we investigated physiological and biochemical responses of the sciatic nerves deranged by taxol injection or crush injury in the rats. METHODS: Dissociated Schwann cells and neurons were prepared from the sciatic nerve and dorsal root ganglia (DRG) respectively and were treated with taxol and BGJTD...
October 22, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27722602/relating-rheology-and-tribology-of-commercial-dairy-colloids-to-sensory-perception
#13
Laura Laguna, Grace Farrell, Michael Bryant, Ardian Morina, Anwesha Sarkar
This study aims to investigate the relationship between rheological and tribological properties of commercial full fat and fat-free/low fat versions of liquid and soft solid colloidal systems (milk, yoghurt, soft cream cheese) with their sensory properties. Oscillatory measurements (strain, frequency), flow curves and tribological measurements (lubrication behaviour using Stribeck analysis) were conducted. Oral condition was mimicked using artificial saliva at 37 (○)C. Discrimination test was conducted by 63 untrained consumers, followed by a qualitative questionnaire...
September 22, 2016: Food & Function
https://www.readbyqxmd.com/read/27694783/local-vs-general-anaesthesia-in-the-development-of-neurosensory-disturbances-after-mandibular-third-molars-extraction-a-retrospective-study-of-534-cases
#14
F Costantinides, M Biasotto, M Maglione, R Di Lenarda
BACKGROUND: The choice of the anaesthetic modality is one of the primary steps during planning of third molar surgery. The aim of the present study was to compare the risk of developing neurological injures of the inferior alveolar nerve (IAN) and lingual nerve (LN) in patients treated for wisdom teeth removal under general anaesthesia (GA) with a group treated under local anaesthesia (LA). MATERIAL AND METHODS: This is an observational retrospective, unicentric study; between September 2013 and September 2014, 534 patients underwent third molar surgery, 194 (36,3%) under GA and 340 (63,7%) under LA by the same oral surgeon...
November 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27684535/sensory-topography-of-oral-structures
#15
Shethal Bearelly, Steven W Cheung
Importance: Sensory function in the oral cavity and oropharynx is integral to effective deglutition and speech production. The main hurdle to evaluation of tactile consequences of upper aerodigestive tract diseases and treatments is access to a reliable clinical tool. We propose a rapid and reliable procedure to determine tactile thresholds using buckling monofilaments to advance care. Objective: To develop novel sensory testing monofilaments and map tactile thresholds of oral cavity and oropharyngeal structures...
January 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27658608/stellantchasmus-falcatus-digenea-heterophyidae-in-cambodia-discovery-of-metacercariae-in-mullets-and-recovery-of-adult-flukes-in-an-experimental-hamster
#16
Jong-Yil Chai, Woon-Mok Sohn, Byoung-Kuk Na, Hoo-Gn Jeoung, Muth Sinuon, Duong Socheat
Stellantchasmus falcatus (Digenea: Heterophyidae) is first reported from Cambodia through recovery of the metacercariae from mullet fish and adult flukes from an experimentally infected hamster. We purchased 7 mullets, Chelon macrolepis, in a local market of Phnom Penh, Cambodia, and each of them was examined by the artificial digestion method on May 2010. The metacercariae of S. falcatus were detected in all mullets (100%) examined, and their average density was 177 per fish. They were elliptical, 220×168 μm in average size...
August 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/27606043/sensory-characterization-of-bowel-cleansing-solutions
#17
Ala I Sharara, Hamza Daroub, Camille Georges, Rani Shayto, Ralph Nader, Jean Chalhoub, Ammar Olabi
AIM: To evaluate the sensory characteristics of commercial bowel cleansing preparations. METHODS: Samples of 4 commercially available bowel cleansing preparations, namely polyethylene glycol electrolyte solution (PEG), PEG + ascorbic acid (PEG-Asc), sodium picosulfate (SPS), and oral sodium sulfate (OSS) were prepared according to the manufacturer's instructions. Descriptive analysis was conducted (n = 14) using a 15-cm line scale with the Compusense at-hand(®) sensory evaluation software...
August 10, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27568306/fine-motor-control-of-the-jaw-following-alteration-of-orofacial-afferent-inputs
#18
Abhishek Kumar, Eduardo Castrillon, Mats Trulsson, Krister G Svensson, Peter Svensson
OBJECTIVE: The study was designed to investigate if alteration of different orofacial afferent inputs would have different effects on oral fine motor control and to test the hypothesis that reduced afferent inputs will increase the variability of bite force values and jaw muscle activity, and repeated training with splitting of food morsel in conditions with reduced afferent inputs would decrease the variability and lead to optimization of bite force values and jaw muscle activity. MATERIAL METHODS: Forty-five healthy volunteers participated in a single experimental session and were equally divided into incisal, mucosal, and block anesthesia groups...
March 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27556825/posture-and-body-balance-of-schoolchildren-aged-8-to-12-years-with-and-without-oral-breathing
#19
Bruna Roggia, Valdete Alves Valentins Dos Santos, Bruna Correa, Ângela Garcia Rossi
PURPOSE: This study aims to evaluate the posture and body balance of students with and without oral breathing, as well as to verify whether there is a correlation between the values obtained in this evaluation and those of the analysis of sensory systems. METHODS: The research was conducted with school children aged 8 to 12 years. The sample was subdivided into two study groups: schoolchildren with oral breathing and school children without oral breathing (control)...
July 2016: CoDAS
https://www.readbyqxmd.com/read/27541635/effect-of-topical-lidocaine-in-the-oral-and-facial-regions-on-tactile-sensory-and-pain-thresholds
#20
Ichiro Okayasu, Osamu Komiyama, Takao Ayuse, Antoon De Laat
OBJECTIVE: The aim of the present study was to examine the effect of lidocaine application to the face, tongue and hand on sensory and pain thresholds of symptom-free subjects. DESIGN: Eighteen females (mean age 25.7 years, range 22-38) participated. Using Semmes-Weinstein monofilaments, the tactile detection threshold (TDT) and the filament-prick pain detection threshold (FPT) were measured on the cheek skin (CS), tongue tip (TT) and palm side of the thenar skin (TS)...
December 2016: Archives of Oral Biology
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