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https://www.readbyqxmd.com/read/27845440/odour-induced-analgesia-mediated-by-hypothalamic-orexin-neurons-in-mice
#1
Shogo Tashiro, Ran Yamaguchi, Sodemi Ishikawa, Takeshi Sakurai, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani
Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds mediated by olfaction have not been thoroughly examined. We performed behavioural pain tests under odourant vapour exposure in mice. Among six odourant molecules examined, linalool significantly increased the pain threshold and attenuated pain behaviours...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27827953/blocking-trpa1-in-respiratory-disorders-does-it-hold-a-promise
#2
REVIEW
Indranil Mukhopadhyay, Abhay Kulkarni, Neelima Khairatkar-Joshi
Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is expressed abundantly on the C fibers that innervate almost entire respiratory tract starting from oral cavity and oropharynx, conducting airways in the trachea, bronchi, terminal bronchioles, respiratory bronchioles and upto alveolar ducts and alveoli. Functional presence of TRPA1 on non-neuronal cells got recognized recently. TRPA1 plays a well-recognized role of "chemosensor", detecting presence of exogenous irritants and endogenous pro-inflammatory mediators that are implicated in airway inflammation and sensory symptoms like chronic cough, asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis and cystic fibrosis...
November 5, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27815794/dental-health-and-odontogenic-infections-among-6-to-16-year-old-german-students-with-special-health-care-needs-shcn
#3
Marco Dziwak, Roswitha Heinrich-Weltzien, Kathrin Limberger, Susanne Ifland, Ilka Gottstein, Thomas Lehmann, Ina M Schüler
OBJECTIVES: This cross-sectional study aimed to assess dental health and odontogenic infections in students with special health care needs (SHCN) in the Free State of Thuringia, Germany. METHODS: From 1283 students with SHCN aged 6-16 years, 66.0 % (n = 848 of whom are 35.7 % females and 64.3 % males) with intellectual/learning disabilities (ID/LD), physical disabilities (PD), and sensory disorders (SD) participated after informed consent in oral examinations according to WHO standards...
November 5, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27792799/characterization-of-burning-mouth-syndrome-in-patients-with-parkinson-s-disease
#4
David Bonenfant, Pierre H Rompré, Nathalie Rei, Nicolas Jodoin, Valerie Lynn Soland, Veronica Rey, Christine Brefel-Courbon, Fabienne Ory-Magne, Olivier Rascol, Pierre J Blanchet
AIMS: To determine the prevalence and characteristics of burning mouth syndrome (BMS) in a Parkinson's disease (PD) population through a self-administered, custom-made survey. METHODS: A total of 218 surveys were collected during regular outpatient visits at two Movement Disorders Clinics in Montreal (Canada) and Toulouse (France) to gather information about pain experience, PD-related symptoms, and oral and general health. A neurologist confirmed the diagnosis of PD, drug treatment, Hoehn-Yahr stage, and Schwab & England Activity of Daily Living score...
October 2016: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/27771455/enhanced-axonal-regeneration-of-the-injured-sciatic-nerve-by-administration-of-buyang-huanwu-decoction
#5
In Ae Chang, Hee Don Lim, Ki Joong Kim, Hwachul Shin, Uk Namgung
ETHNOPHARMACOLOGICAL RELEVANCE: Buyang Huanwu decoction (BYHWD) has been used in the traditional Chinese medicine for the treatment of cardiovascular and neurological symptoms, and recent experimental studies have begun to provide evidence showing its protective effects on neural cells. Yet, its function for the regenerative responses of axons in the peripheral nerve after injury is not known. AIM OF THE STUDY: The primary objective of the present study was to explore that BYHWD is involved in growth-promoting activity of the peripheral nerve axons after injury...
October 19, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27770785/bogijetong-decoction-and-its-active-herbal-components-protect-the-peripheral-nerve-from-damage-caused-by-taxol-or-nerve-crush
#6
So Hyun Ahn, In Ae Chang, Ki-Joong Kim, Chul-Jung Kim, Uk Namgung, Chung-Sik Cho
BACKGROUND: Bogijetong decoction (BGJTD) is a herbal drug formulation used in the traditional Asian medicine to treat neuropathic insults associated with diabetes and anticancer therapy. To understand the biological basis of BGJTD on protective effects against neuropathy, we investigated physiological and biochemical responses of the sciatic nerves deranged by taxol injection or crush injury in the rats. METHODS: Dissociated Schwann cells and neurons were prepared from the sciatic nerve and dorsal root ganglia (DRG) respectively and were treated with taxol and BGJTD...
October 22, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27722602/relating-rheology-and-tribology-of-commercial-dairy-colloids-to-sensory-perception
#7
Laura Laguna, Grace Farrell, Michael Bryant, Ardian Morina, Anwesha Sarkar
This study aims to investigate the relationship between rheological and tribological properties of commercial full fat and fat-free/low fat versions of liquid and soft solid colloidal systems (milk, yoghurt, soft cream cheese) with their sensory properties. Oscillatory measurements (strain, frequency), flow curves and tribological measurements (lubrication behaviour using Stribeck analysis) were conducted. Oral condition was mimicked using artificial saliva at 37 (○)C. Discrimination test was conducted by 63 untrained consumers, followed by a qualitative questionnaire...
September 22, 2016: Food & Function
https://www.readbyqxmd.com/read/27694783/local-vs-general-anaesthesia-in-the-development-of-neurosensory-disturbances-after-mandibular-third-molars-extraction-a-retrospective-study-of-534-cases
#8
F Costantinides, M Biasotto, M Maglione, R Di Lenarda
BACKGROUND: The choice of the anaesthetic modality is one of the primary steps during planning of third molar surgery. The aim of the present study was to compare the risk of developing neurological injures of the inferior alveolar nerve (IAN) and lingual nerve (LN) in patients treated for wisdom teeth removal under general anaesthesia (GA) with a group treated under local anaesthesia (LA). MATERIAL AND METHODS: This is an observational retrospective, unicentric study; between September 2013 and September 2014, 534 patients underwent third molar surgery, 194 (36,3%) under GA and 340 (63,7%) under LA by the same oral surgeon...
November 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27684535/sensory-topography-of-oral-structures
#9
Shethal Bearelly, Steven W Cheung
Importance: Sensory function in the oral cavity and oropharynx is integral to effective deglutition and speech production. The main hurdle to evaluation of tactile consequences of upper aerodigestive tract diseases and treatments is access to a reliable clinical tool. We propose a rapid and reliable procedure to determine tactile thresholds using buckling monofilaments to advance care. Objective: To develop novel sensory testing monofilaments and map tactile thresholds of oral cavity and oropharyngeal structures...
September 29, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27658608/stellantchasmus-falcatus-digenea-heterophyidae-in-cambodia-discovery-of-metacercariae-in-mullets-and-recovery-of-adult-flukes-in-an-experimental-hamster
#10
Jong-Yil Chai, Woon-Mok Sohn, Byoung-Kuk Na, Hoo-Gn Jeoung, Muth Sinuon, Duong Socheat
Stellantchasmus falcatus (Digenea: Heterophyidae) is first reported from Cambodia through recovery of the metacercariae from mullet fish and adult flukes from an experimentally infected hamster. We purchased 7 mullets, Chelon macrolepis, in a local market of Phnom Penh, Cambodia, and each of them was examined by the artificial digestion method on May 2010. The metacercariae of S. falcatus were detected in all mullets (100%) examined, and their average density was 177 per fish. They were elliptical, 220×168 μm in average size...
August 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/27606043/sensory-characterization-of-bowel-cleansing-solutions
#11
Ala I Sharara, Hamza Daroub, Camille Georges, Rani Shayto, Ralph Nader, Jean Chalhoub, Ammar Olabi
AIM: To evaluate the sensory characteristics of commercial bowel cleansing preparations. METHODS: Samples of 4 commercially available bowel cleansing preparations, namely polyethylene glycol electrolyte solution (PEG), PEG + ascorbic acid (PEG-Asc), sodium picosulfate (SPS), and oral sodium sulfate (OSS) were prepared according to the manufacturer's instructions. Descriptive analysis was conducted (n = 14) using a 15-cm line scale with the Compusense at-hand(®) sensory evaluation software...
August 10, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27568306/fine-motor-control-of-the-jaw-following-alteration-of-orofacial-afferent-inputs
#12
Abhishek Kumar, Eduardo Castrillon, Mats Trulsson, Krister G Svensson, Peter Svensson
OBJECTIVE: The study was designed to investigate if alteration of different orofacial afferent inputs would have different effects on oral fine motor control and to test the hypothesis that reduced afferent inputs will increase the variability of bite force values and jaw muscle activity, and repeated training with splitting of food morsel in conditions with reduced afferent inputs would decrease the variability and lead to optimization of bite force values and jaw muscle activity. MATERIAL METHODS: Forty-five healthy volunteers participated in a single experimental session and were equally divided into incisal, mucosal, and block anesthesia groups...
August 27, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27556825/posture-and-body-balance-of-schoolchildren-aged-8-to-12-years-with-and-without-oral-breathing
#13
Bruna Roggia, Valdete Alves Valentins Dos Santos, Bruna Correa, Ângela Garcia Rossi
PURPOSE: This study aims to evaluate the posture and body balance of students with and without oral breathing, as well as to verify whether there is a correlation between the values obtained in this evaluation and those of the analysis of sensory systems. METHODS: The research was conducted with school children aged 8 to 12 years. The sample was subdivided into two study groups: schoolchildren with oral breathing and school children without oral breathing (control)...
July 2016: CoDAS
https://www.readbyqxmd.com/read/27541635/effect-of-topical-lidocaine-in-the-oral-and-facial-regions-on-tactile-sensory-and-pain-thresholds
#14
Ichiro Okayasu, Osamu Komiyama, Takao Ayuse, Antoon De Laat
OBJECTIVE: The aim of the present study was to examine the effect of lidocaine application to the face, tongue and hand on sensory and pain thresholds of symptom-free subjects. DESIGN: Eighteen females (mean age 25.7 years, range 22-38) participated. Using Semmes-Weinstein monofilaments, the tactile detection threshold (TDT) and the filament-prick pain detection threshold (FPT) were measured on the cheek skin (CS), tongue tip (TT) and palm side of the thenar skin (TS)...
August 5, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27514937/levodopa-carbidopa-intestinal-gel-therapy-for-advanced-parkinson-disease-an-early-toxic-effect-for-small-nerve-fibers
#15
Grazia Devigili, Sara Rinaldo, Christian Lettieri, Roberto Eleopra
INTRODUCTION: Peripheral neuropathy related to levodopa/carbidopa intestinal gel (LCIG) therapy for advanced Parkinson disease (PD) is under investigation and is debated in the literature. The purpose of the study was to detect whether small nerve fibers are damaged during LCIG infusion. METHODS: Five advanced PD patients were enrolled prior to starting LCIG infusion. Six PD patients on oral levodopa (LD) treatment and 6 PD patients naïve to LD were also enrolled...
August 12, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27511471/oral-sensory-nerve-damage-causes-and-consequences
#16
REVIEW
Derek J Snyder, Linda M Bartoshuk
Oral sensations (i.e., taste, oral somatosensation, retronasal olfaction) are integrated into a composite sense of flavor, which guides dietary choices with long-term health impact. The nerves carrying this input are vulnerable to peripheral damage from multiple sources (e.g., otitis media, tonsillectomy, head injury), and this regional damage can boost sensations elsewhere in the mouth because of central interactions among nerve targets. Mutual inhibition governs this compensatory process, but individual differences lead to variation in whole-mouth outcomes: some individuals are unaffected, others experience severe loss, and some encounter sensory increases that may (if experienced early in life) elevate sweet-fat palatability and body mass...
June 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27477575/subacute-autonomic-and-sensory-neuropathy-closely-related-to-cytomegalovirus-infection-preceded-by-frequent-syncopal-attacks
#17
Koichi Nakao, Michito Namekawa, Soichi Kondo, Sayaka Ono, Imaharu Nakano
A 73-year-old woman who had hypertension developed a slight fever and general malaise with laboratory-proven hepatic dysfunction as well as frequent syncopal attacks 3 months before admission to our hospital. One month later, she developed urinary retention and distal limb numbness. Upon admission, her neurological examination showed reduced limb tendon reflexes, glove and stocking-type numbness, and diminished senses of touch, temperature, pain, and distal leg vibration and position. Serum cytomegalovirus (CMV) IgM antibody and CMV IgG antibody were elevated on admission, and both decreased thereafter, confirming CMV infection...
August 31, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27349538/short-term-effects-of-orthognathic-surgery-on-somatosensory-function-and-recovery-pattern-in-the-early-postoperative-period
#18
Ko Dezawa, Noboru Noma, Kosuke Watanabe, Yuka Sato, Ryutaro Kohashi, Morio Tonogi, Gary Heir, Eli Eliav, Yoshiki Imamura
We examined the short-term surgical effects of orthognathic surgery on somatosensory function. Observations were made over a short period: 3 months postoperatively. In total, 14 patients and 32 healthy controls participated. Among the 14 patients, one underwent bilateral sagittal split osteotomy alone and 13 underwent bilateral sagittal split osteotomy in combination with a Le Fort I osteotomy. A modified quantitative sensory testing (QST) protocol (the German Research Network on Neuropathic Pain, DFNS) was used to evaluate clinically the skin of the chin for sensory disturbances before surgery and at 1 week, 1 month, and 3 months postoperatively...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27295489/evaluation-of-the-antihyperalgesic-effect-of-tapentadol-in-two-human-evoked-pain-models-the-tapcapmentho-pilot-trial
#19
M Förster, S Helfert, R Dierschke, M Großkopf, P Hüllemann, T Keller, R Baron, A Binder
OBJECTIVE: Tapentadol is effective in the treatment of neuropathic and nociceptive pain and in acute and chronic pain conditions; two mechanisms combining opioid µ-receptor agonism and noradrenergic reuptake inhibition underlie its analgesic effect. RESEARCH DESIGN AND METHODS: With this single-center, placebo-controlled, double-blind, cross-over pilot-study, we investigated the antihyperalgesic effect of a single oral dose of 100 mg immediate-release tapentadol on thermal and mechanical hyperalgesia in two human models (i...
September 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27292295/immunocytochemical-organization-and-sour-taste-activation-in-the-rostral-nuc-solitary-tract-of-mice
#20
Jennifer M Stratford, John A Thompson, Thomas E Finger
Sensory inputs from the oropharynx terminate in both the trigeminal brainstem complex and the rostral part of the nucleus of the solitary tract (nTS). Taste information is conveyed via the facial and glossopharyngeal nerves while general mucosal innervation is carried by the trigeminal and glossopharyngeal nerves. In contrast, the caudal nTS receives general visceral information largely from the vagus nerve. Although the caudal nTS shows clear morphological and molecularly delimited subdivisions, the rostral part does not...
June 13, 2016: Journal of Comparative Neurology
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