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https://www.readbyqxmd.com/read/29771453/functionalization-of-lipid-based-nutrient-supplement-with-%C3%AE-cyclodextrin-inclusions-of-oregano-essential-oil
#1
Shashank Gaur, Emely C Lopez, Ankur Ojha, Juan E Andrade
Intestinal parasitic infection is one of the main causes of acute undernutrition in children. Oral consumption of oregano essential oil (OEO) can reduce intestinal parasitic infections, however, its addition to therapeutic and supplementary foods is hampered by its undesirable flavor. The objective of this study was to develop a functional lipid-based nutrient supplement (LNS) containing OEO, which is stable, acceptable and provides targeted intestinal delivery of bioactive. β-cyclodextrin (β-CyD) inclusion complexes of OEO (β-CyD-OEO), and carvacrol (β-CyD-CV) (1:1 molar) were prepared using slurry complexation (-20 °C) method and characterized based on encapsulation efficiency, moisture content, morphology, and 2-phase in vitro digestion stability...
May 17, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29758252/depression-resistant-phenotype-in-mice-overexpressing-regulator-of-g-protein-signaling-8-rgs8
#2
Yuki Kobayashi, Risa Takemoto, Shogo Yamato, Tomoya Okada, Michihiko Iijima, Yoshikatsu Uematsu, Shigeyuki Chaki, Yumiko Saito
Regulator of G protein signaling (RGS) proteins are negative regulators of heterotrimeric G proteins that act by accelerating Gα-mediated GTPase activity to terminate G protein-coupled receptor-associated signaling. RGS8 is expressed in several brain regions involved with movement and mood. To investigate the role of RGS8 in vivo, we generated transgenic mice overexpressing brain RGS8 (RGS8tg). RGS8 gene and protein expressions were examined by real-time PCR and immunohistochemistry, respectively, and a significant increase in RGS8 protein was detected in the hippocampal CA1 region compared with wild-type mice (WT)...
May 11, 2018: Neuroscience
https://www.readbyqxmd.com/read/29744194/measurement-reliability-of-current-perception-threshold-and-pain-threshold-in-parallel-with-blood-sampling
#3
Takahiro Ogawa, Suguru Kimoto, Yoshio Nakashima, Nobuhiko Furuse, Masanori Ono, So Furokawa, Masakazu Okubo, Takahiro Yazaki, Yasuhiko Kawai
The irritation and pain associated with oral blood sampling necessary to monitor glycemic control can alter oral sensation, but no studies have measured the reliability of oral sensation testing when performed concurrently with blood sampling. The primary and secondary aims of this study were to verify the measurement reliability of current perception threshold (CPT) and pain threshold (PT) tests performed before and after blood sampling and to investigate the differences in CPTs/PTs obtained from the oral cavity, hand, and foot, respectively...
August 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29742109/effect-of-single-dose-imipramine-on-chronic-low-back-and-experimental-pain-a-randomized-controlled-trial
#4
Jürg Schliessbach, Andreas Siegenthaler, Lukas Bütikofer, Andreas Limacher, Peter Juni, Pascal H Vuilleumier, Ulrike Stamer, Lars Arendt-Nielsen, Michele Curatolo
Antidepressants are frequently prescribed as co-analgesics in chronic pain. While their efficacy is well documented for neuropathic pain, the evidence is less clear in musculoskeletal pain conditions. The present study therefore evaluated the effect of the tricyclic antidepressant imipramine on chronic low-back pain in a randomized, double-blinded placebo-controlled design. To explore the mechanisms of action and the influence of drug metabolism, multimodal quantitative sensory tests (QST) and genotyping for cytochrome P450 2D6 (CYP2D6) were additionally performed...
2018: PloS One
https://www.readbyqxmd.com/read/29720841/a-novel-method-to-mask-the-bitter-taste-of-berberine-hydrochloride-powder-surface-modification
#5
Hong Jiang, Dingkun Zhang, Jing He, Xue Han, Junzhi Lin, Yang Lan, Xi Xiong, Lingying Yu, Ming Yang, Li Han
Background: Berberine hydrochloride (BH) is widely used as a nonprescription drug to treat diarrhea without drug resistance and side effects worldwide. However, its drastic bitterness affects patient compliance severely. Hence, it is essential to mask the bitter taste of BH. Objective: Powder surface modification technology is attempted to mask the bitterness of BH through changing the surface properties in vibromill. The purpose of this study was to apply this technology to mask the bitterness of BH and improve the patient compliance...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29717363/oromandibular-dystonia-screening-questionnaire-for-differential-diagnosis
#6
Kazuya Yoshida
OBJECTIVES: Oromandibular dystonia, which is characterized by stereotypic, task-specific, or sustained contractions of masticatory and/or lingual muscles, is frequently misdiagnosed as temporomandibular disorders or psychogenic disease. Diagnostic delay in oromandibular dystonia is not acceptable; thus, a screening tool that can distinguish this condition from a temporomandibular disorder may be helpful for medical professionals unfamiliar with involuntary movements or temporomandibular disorders...
May 2, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29694798/regeneration-of-the-rhopalium-and-the-rhopalial-nervous-system-in-the-box-jellyfish-tripedalia-cystophora
#7
Sebastian-Alexander Stamatis, Katrine Worsaae, Anders Garm
Cubozoans have the most intricate visual apparatus within Cnidaria. It comprises four identical sensory structures, the rhopalia, each of which holds six eyes of four morphological types. Two of these eyes are camera-type eyes that are, in many ways, similar to the vertebrate eye. The visual input is used to control complex behaviors, such as navigation and obstacle avoidance, and is processed by an elaborate rhopalial nervous system. Several studies have examined the rhopalial nervous system, which, despite a radial symmetric body plan, is bilaterally symmetrical, connecting the two sides of the rhopalium through commissures in an extensive neuropil...
February 2018: Biological Bulletin
https://www.readbyqxmd.com/read/29653247/somatosensory-changes-at-forearm-donor-sites-following-three-different-surgical-flap-techniques
#8
Fang Wang, Xu Ding, Jinglu Zhang, Xiaomeng Song, Yunong Wu, Peter Svensson, Kelun Wang
BACKGROUND: The aim of this study was to investigate the somatosensory changes at the forearm donor region after using different types of modified flap surgical techniques. METHODS: Thirty-one patients, who underwent oral and maxillofacial reconstructive surgery involving the use of a traditional radial forearm flap (TRFF) or two modified radial forearm flap techniques (MRFF-I; MRFF-II), participated in the study. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), pressure pain threshold (PPT), mechanical detection threshold (MDT), and mechanical pain threshold (MPT) were assessed at four sites of the forearms corresponding to the middle of the vascular pedicle (VP) area, the middle of the forearm flap area, and the corresponding contralateral sites (cVP and cFF) at about 5...
April 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29648522/the-impact-of-recurrent-laryngeal-nerve-lesion-on-oropharyngeal-muscle-activity-and-sensorimotor-integration-in-an-infant-pig-model
#9
Katherine R DeLozier, Francois David Henry Gould, Jocelyn Ohlemacher, Allan J Thexton, Rebecca Z German
The successful performance of a swallow requires dynamic integration, between a wide range of sensory inputs and muscle activities, to produce the coordinated kinematics of oropharyngeal structures. Damage to the recurrent laryngeal nerve (RLN) produces dysphagia in infants, with food or liquid entering the airway, despite this nerve having minimal direct sensory or motor connections to the act of swallowing, apart from vocal fold closure. Previous results have demonstrated that a complete RLN lesion disrupts both performance and kinematics prior to initiation of the pharyngeal swallow in infants...
April 12, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29595092/comparative-safety-evaluation-of-riot-control-agents-of-synthetic-and-natural-origin
#10
Ravindra M Satpute, Pramod K Kushwaha, D P Nagar, P V L Rao
Riot control agents (RCA) are lachrymatory, irritating compounds which temporarily incapacitate the uncontainable crowd. Ortho-Chlorobenzylidene-malononitrile (CS), 2-chloroacetophenone (CN), dibenz[b,f]1:4-oxazepine (CR), and nonivamide (PAVA) are synthetic RCAs, while oleoresin extract of chili known as oleoresin capsicum (OC) a natural irritant has been in use by various law enforcement agencies. Though efficacy of these agents is beyond doubt, they suffer from certain drawbacks including toxicity, production cost, and ecological compatibility...
February 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29593900/the-palatability-of-lopinavir-and-ritonavir-delivered-by-an-innovative-freeze-dried-fast-dissolving-tablet-formulation
#11
David W Pittman, Alexandra M Brantly, Alexandra L Drobonick, Hannah T King, Daniel C Mesta, Caroline G Richards, Manjari Lal, Manshun Lai
Negative hedonic sensory qualities of HIV antiretroviral drugs often reduce patient adherence particularly in pediatric populations requiring oral consumption. This study examines the palatability of an innovative delivery mechanism utilizing a freeze-drying-in-blister approach to create fast-dissolving tablets (FDTs) containing a fixed-dose combination of lopinavir and ritonavir (LPV/r). Consumption patterns of solutions during brief-access and long-term testing and baby foodstuff consumption were analyzed to evaluate the orosensory detection and avoidance of placebo FDTs containing no LPV/r (FDT-) and FDTs containing LPV/r (FDT+)...
2018: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29593794/comparative-analysis-of-the-effectiveness-of-the-topical-administration-of-benzocaine-and-emla-%C3%A2-on-oral-pain-and-tactile-sensitivity
#12
David Gomes de Alencar Gondim, Antonio Marcos Montagner, Ivo Cavalcante Pita-Neto, Romildo José de Siqueira Bringel, Francisco Aurelio Luchesi Sandrini, Eduardo Fernando Chaves Moreno, Amanda Mendes de Sousa, Andreza Bastos Correia
Objectives: To compare the effectiveness of the topical administration of benzocaine and EMLA on oral pain and tactile sensitivity. Materials and Methods: A randomized, double-blind, split-mouth clinical trial was carried out with 20 volunteers. The sensorial and quantitative tests were applied before the contact with topical anesthetic and after the application. Results: In the superficial tactile perception test, when we compared each group singly, there were statistically significant values in the decrease of superficial tactile perception when compared to the moment prior to the application of anesthetic agents...
2018: International Journal of Dentistry
https://www.readbyqxmd.com/read/29565948/a-randomized-double-blind-study-of-the-effects-of-a-sustained-release-formulation-of-sodium-nitrite-sr-nitrite-on-patients-with-diabetic-neuropathy
#13
Amol Soin, Glen Bock, Anthony Giordano, Chirag Patel, David Drachman
BACKGROUND: Sodium nitrite has been reported to be effective in reducing chronic peripheral pain. OBJECTIVES: To evaluate the safety and efficacy of 40 and 80 mg, BID, of an oral sustained release formulation of sodium nitrite (SR-nitrite) in patients suffering from diabetic neuropathy, and to determine whether SR-nitrite would reduce the frequency of headaches reported previously by subjects receiving the same doses of an immediate release formulation. STUDY DESIGN: Phase II, single-center, randomized, double-blind, placebo controlled clinical trial...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29504187/clinical-testing-of-three-novel-transient-receptor-potential-cation-channel-subfamily-v-member-1-antagonists-in-a-pharmacodynamic-intradermal-capsaicin-model
#14
E Sjögren, T Kullenberg, B Jonzon, M Segerdahl, O Stålberg, M M Halldin, A K Sundgren-Andersson
BACKGROUND: The transient receptor potential cation channel subfamily V 1 (TRPV1) is involved in nociception and has thus been of interest for drug developers, as a target for novel analgesics. However, several oral TRPV1 antagonists have failed in development, and novel approaches to target TRPV1 with innovative chemistry are needed. METHOD: This work describes an intradermal microdosing approach in humans for pharmacodynamic deductions and pharmacological profiling of compounds...
March 5, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29501426/sensory-dysfunction-and-sexuality-in-the-u-s-population-of-older-adults
#15
Selena Zhong, Jayant M Pinto, Kristen E Wroblewski, Martha K McClintock
BACKGROUND: The sexual experience is shaped by sensory function; with aging, sensory dysfunction may interfere with sexuality and sexual behavior between partners. Specifically, older adults with age-related sensory dysfunction may have less sexual activity than those with better sensory function. In addition, since sexual desire and attraction rests in part upon sensory function, sensory dysfunction may also be associated with less sexual motivation. AIM: To test the association between sexual activity and motivation in older adults and their sensory dysfunction...
April 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29463908/neural-responses-to-cues-paired-with-methamphetamine-in-healthy-volunteers
#16
Kathryne Van Hedger, Sarah K Keedy, Leah M Mayo, Markus Heilig, Harriet de Wit
Drug cues, or conditioned responses to stimuli paired with drugs, are widely believed to promote drug use. The acquisition of these conditioned responses has been well characterized in laboratory animals: neutral stimuli paired with drugs elicit conditioned responses resembling the motivational and incentive properties of the drug itself. However, few studies have examined acquisition of conditioning, or the nature of the conditioned response, in humans. In this study, we used fMRI to examine neural responses to stimuli that had been paired with methamphetamine or placebo in healthy young adults...
January 30, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29411466/writing-fluency-in-patients-with-low-grade-glioma-before-and-after-surgery
#17
Malin Antonsson, Charlotte Johansson, Lena Hartelius, Ingrid Henriksson, Francesca Longoni, Åsa Wengelin
BACKGROUND: Low-grade glioma (LGG) is a type of brain tumour often situated in or near areas involved in language, sensory or motor functions. Depending on localization and tumour characteristics, language or cognitive impairments due to tumour growth and/or surgical resection are obvious risks. One task that may be at risk is writing, both because it requires intact language and memory function and because it is a very complex and cognitively demanding task. The most commonly reported language deficit in LGG patients is oral lexical-retrieval difficulties, and poor lexical retrieval would be expected to affect writing fluency...
February 7, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29398172/an-innovative-virtual-reality-training-tool-for-orthognathic-surgery
#18
Y Pulijala, M Ma, M Pears, D Peebles, A Ayoub
Virtual reality (VR) surgery using Oculus Rift and Leap Motion devices is a multi-sensory, holistic surgical training experience. A multimedia combination including 360° videos, three-dimensional interaction, and stereoscopic videos in VR has been developed to enable trainees to experience a realistic surgery environment. The innovation allows trainees to interact with the individual components of the maxillofacial anatomy and apply surgical instruments while watching close-up stereoscopic three-dimensional videos of the surgery...
February 1, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29379943/efficacy-of-oral-mixed-tocotrienols-in-diabetic-peripheral-neuropathy-a-randomized-clinical-trial
#19
Chee Peng Hor, Wai Yee Fung, Hock Aun Ang, Sheau Chin Lim, Li Ying Kam, Su-Way Sim, Luen Hui Lim, Wai Yee Choon, Jia Woei Wong, Alan Swee Hock Ch'ng, Kelvin Khai Meng Beh, Hong Chin Wee, Loke Meng Ong, Nurzalina Abdul Karim Khan, Syed Azhar Syed Sulaiman, Ibrahim Lutfi Shuaib, Adlina Bakar, Yusnita Yusof, Yusmawati Mohd Yusof, Fatimah Abu Bakar, Wei Shuong Tang, Hoon Lang Teh, Normala Abdul Wahid, Suriani Saaidin, Najihah Idris, Chee Kin Yoon, Hoon Ngoh Ong, Jayasumithra T Ganapathy, Ching Ee Loo, Michelle M Samy, Hadzlinda Zainal, Shalini C Sree Dharan, Bee Yen Ooi, Pei Yeing Teoh, Yi Loon Tye, Chin Aun Yeoh, Dy Win Low, Irene Looi, Kah Hay Yuen
Importance: Management of painful diabetic peripheral neuropathy remains challenging. Most therapies provide symptomatic relief with varying degrees of efficacy. Tocotrienols have modulatory effects on the neuropathy pathway and may reduce neuropathic symptoms with their antioxidative and anti-inflammatory activities. Objective: To evaluate the efficacy of oral mixed tocotrienols for patients with diabetic peripheral neuropathy. Design, Setting, and Participants: The Vitamin E in Neuroprotection Study (VENUS) was a parallel, double-blind, placebo-controlled trial that recruited participants from January 30, 2011, to December 7, 2014, with 12 months of follow-up...
April 1, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29336237/masticatory-function-and-oral-stereognosis-in-bruxers
#20
Mariana Barbosa Câmara-Souza, Olívia Maria Costa Figueredo, Renata Cunha Matheus Rodrigues Garcia
OBJECTIVE: To compare the mastication and oral sensory function of individuals with and without sleep bruxism. METHODS: The sample comprised 60 volunteers, of which 30 were bruxers (mean age = 30.5 ± 6.0) and 30 non-bruxers (mean age = 28.6 ± 3.3). Sleep bruxism was clinically diagnosed and confirmed using the Bruxoff® device. Mastication was evaluated according to swallowing threshold and masticatory efficiency. Swallowing threshold was determined from the median particle size of Optosil®, obtained after an individualized number of masticatory cycles, which was first determined by chewing peanuts; masticatory efficiency was estimated by the sieving method...
January 16, 2018: Cranio: the Journal of Craniomandibular Practice
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