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https://www.readbyqxmd.com/read/29156700/linc00152-suppresses-apoptosis-and-promotes-migration-by-sponging-mir-4767-in-vascular-endothelial-cells
#1
Wei Teng, Chunguang Qiu, Zhaohui He, Guoliang Wang, Yongliang Xue, Xuezhi Hui
Dysfunction of vascular endothelial cells (VECs), such as increased apoptosis and diminished migration, is closely connected with most cardiovascular diseases and angiogenesis-related events. LncRNAs have been involved in regulation of many pathological processes, but their roles in vascular endothelial function are hardly underreported. Here, we explore the role of a intergenic lncRNA named linc00152 in the apoptosis and migration of VECs. We found that linc00152 was downregulated in human umbilical vein VECs (HUVECs) in a dose- and time-dependent manner following treatment with oxLDL, which is a typical proinflammatory factor in the initiation and progression of vascular endothelial dysfunction...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156647/effects-of-nutritional-interventions-during-pregnancy-on-infant-and-child-cognitive-outcomes-a-systematic-review-and-meta-analysis
#2
REVIEW
Rachael M Taylor, Shanna M Fealy, Alessandra Bisquera, Roger Smith, Clare E Collins, Tiffany-Jane Evans, Alexis J Hure
BACKGROUND: Epidemiological studies have demonstrated that folate, iodine and iron intake during pregnancy impacts on foetal brain development and cognitive function. However, in human studies, the relationship with other dietary nutrients is less clear. OBJECTIVE: This systematic review aims to critically appraise the current literature and meta-analyses results from nutritional interventions during pregnancy that aimed to optimise infant and child cognitive outcomes...
November 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29156643/melanoma-genetic-abnormalities-tumor-progression-clonal-evolution-and-tumor-initiating-cells
#3
REVIEW
Ugo Testa, Germana Castelli, Elvira Pelosi
Melanoma is an aggressive neoplasia issued from the malignant transformation of melanocytes, the pigment-generating cells of the skin. It is responsible for about 75% of deaths due to skin cancers. Melanoma is a phenotypically and molecularly heterogeneous disease: cutaneous, uveal, acral, and mucosal melanomas have different clinical courses, are associated with different mutational profiles, and possess distinct risk factors. The discovery of the molecular abnormalities underlying melanomas has led to the promising improvement of therapy, and further progress is expected in the near future...
November 20, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29156638/development-of-evidence-based-disease-education-literature-for-pakistani-rheumatoid-arthritis-patients
#4
Atta Abbas Naqvi, Mohamed Azmi Hassali, Muhammad Tariq Aftab, Syed Baqir Shyum Naqvi, Fatima Zehra, Rizwan Ahmad, Niyaz Ahmad
Rheumatoid arthritis affects 0.5% to 1% of the population globally and is one of the most common causes of disability. Patient education plays a key role in improving treatment outcomes. The purpose of this study was to discuss the process involved in designing an evidence-based disease education literature for rheumatoid arthritis patients of Pakistan in Urdu language with culturally relevant illustrations. A study was conducted to develop disease education literature using Delphi consensus, content validity, and patient feedback...
November 20, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/29156580/cellular-localization-of-wheat-high-molecular-weight-glutenin-subunits-in-transgenic-rice-grain
#5
Yeong-Min Jo, Kyoungwon Cho, Hye-Jung Lee, Sun-Hyung Lim, Jin Sun Kim, Young-Mi Kim, Jong-Yeol Lee
Rice (Oryza sativa L.) is a primary global food cereal. However, when compared to wheat, rice has poor food processing qualities. Dough that is made from rice flour has low viscoelasticity because rice seed lacks storage proteins that are comparable to gluten protein from wheat. Thus, current research efforts aim to improve rice flour processing qualities through the transgenic expression of viscoelastic proteins in rice seeds. In this study, we characterized the transgenic expression of wheat glutenin subunits in rice seeds...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156513/production-and-characterization-of-keratinolytic-proteases-by-a-chicken-feather-degrading-thermophilic-strain-thermoactinomyces-sp-yt06
#6
Lin Wang, Yuting Qian, Yun Cao, Ying Huang, Zhizhou Chang, Hongying Huang
Thermoactinomyces sp. strain YT06 was isolated from poultry compost and observed to degrade integral chicken feathers at 60°C completely, resulting in the formation of 3.24 mg/mL of free amino acid from 50 mL of culture containing 10 g/L chicken feathers. Strain YT06 could grow and secret keratinase using feather as the only carbon and nitrogen sources without other supplement, but complementation of 10 g/L sucrose and 4 g/L NaNO₃ increased the production of the keratinolytic enzyme. The maximum protease activities obtained were 110 U/mL and keratinase were 42 U/mL...
November 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29156430/chromium-tolerance-bioaccumulation-and-localization-in-plants-an-overview
#7
REVIEW
Vibha Sinha, Kannan Pakshirajan, Rakhi Chaturvedi
In the current industrial scenario, chromium (Cr) as a metal is of great importance, but poses a major threat to the environment. Phytoremediation provides an environmentally sustainable, ecofriendly, cost effective approach for environmental cleanup of Cr. This review presents the current status of phytoremediation research with particular emphasis on cleanup of Cr contaminated soil and water systems. It gives a detailed account of the work done by different authors on the Cr bioavailability, uptake pathway, toxicity and storage in plants following the phytoextraction mechanism...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156419/segmentation-of-the-hippocampus-by-transferring-algorithmic-knowledge-for-large-cohort-processing
#8
Benjamin Thyreau, Kazunori Sato, Hiroshi Fukuda, Yasuyuki Taki
The hippocampus is a particularly interesting target for neuroscience research studies due to its essential role within the human brain. In large human cohort studies, bilateral hippocampal structures are frequently identified and measured to gain insight into human behaviour or genomic variability in neuropsychiatric disorders of interest. Automatic segmentation is performed using various algorithms, with FreeSurfer being a popular option. In this manuscript, we present a method to segment the bilateral hippocampus using a deep-learned appearance model...
November 10, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29156389/assessing-working-memory-in-children-with-adhd-minor-administration-and-scoring-changes-may-improve-digit-span-backward-s-construct-validity
#9
Erica L Wells, Michael J Kofler, Elia F Soto, Hillary S Schaefer, Dustin E Sarver
BACKGROUND: Pediatric ADHD is associated with impairments in working memory, but these deficits often go undetected when using clinic-based tests such as digit span backward. AIMS: The current study pilot-tested minor administration/scoring modifications to improve digit span backward's construct and predictive validities in a well-characterized sample of children with ADHD. METHODS AND PROCEDURES: WISC-IV digit span was modified to administer all trials (i...
November 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29156384/targeting-fgfr-pathway-in-breast-cancer
#10
J Perez-Garcia, E Muñoz-Couselo, J Soberino, F Racca, J Cortes
Developments in breast cancer biology over the last years have permitted deconstructing the molecular profile of the most relevant breast cancer subtypes. This has led to an increase in therapeutic options, including more effective personalized therapy for breast cancer and substantial improvements in patient outcomes. Although currently there are only a few targeted therapies approved for metastatic breast cancer, the discovery of druggable kinase gene alterations has radically changed cancer treatment by providing novel and successfully actionable drug targets...
November 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29156370/a-novel-aerated-surface-flow-constructed-wetland-using-exhaust-gas-from-biological-wastewater-treatment-performance-and-mechanisms
#11
Xinwen Zhang, Zhen Hu, Jian Zhang, Jinlin Fan, Huu Hao Ngo, Wenshan Guo, Chujun Zeng, Yiwen Wu, Siyuan Wang
In this study, a novel aerated surface flow constructed wetland (SFCW) using exhaust gas from biological wastewater treatment was investigated. Compared with un-aerated SFCW, the introduction of exhaust gas into SFCW significantly improved NH4(+)-N, TN and COD removal efficiencies by 68.30 ± 2.06%, 24.92 ± 1.13% and 73.92 ± 2.36%, respectively. The pollutants removal mechanism was related to the microbial abundance and the highest microbial abundance was observed in the SFCW with exhaust gas because of the introduction of exhaust gas from sequencing batch reactor (SBR), and thereby optimizing nitrogen transformation processes...
September 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29156333/short-and-long-term-effects-of-manganese-zinc-and-copper-ions-on-nitrogen-removal-in-nitritation-anammox-process
#12
Huayu Li, Hong Yao, Dayi Zhang, Lushen Zuo, Jia Ren, Jinyuan Ma, Jin Pei, Yaru Xu, Chengyong Yang
This study provided a deep insight into the impacts of trace elements (Mn(2+), Zn(2+) and Cu(2+)) on nitritation-anammox process. For short-term exposure, all the three elements could improve the nitrogen removal rate (NRR) and the optimal concentrations were 2.0 mg/L, 2.0 mg/L and 0.5 mg/L for Mn(2+), Zn(2+) and Cu(2+), respectively. Accordingly, the NRRs were enhanced 54.62%, 45.93% and 44.09%. The long-term experiments were carried out in lab-scale sequencing batch reactors. The surprising results showed that only Mn(2+) addition could enhance the long-term nitritation-anammox process, and the NRR increased from 0...
November 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29156291/engineering-the-next-generation-tin-containing-%C3%AE-titanium-alloys-with-high-strength-and-low-modulus-for-orthopedic-applications
#13
Sumit Bahl, Suvam Das, Satyam Suwas, Kaushik Chatterjee
Metastable β Ti alloys are the new emerging class of biomaterial for load bearing orthopedic applications. However, these alloys in the single β phase microstructure have insufficient strength for use in load bearing applications. It is imperative to strengthen these alloys by carefully designed thermo-mechanical processing routes that typically involve aging treatment. In this investigation two newly designed Sn based β Ti alloys of composition Ti-32Nb-(2, 4) Sn are evaluated. The effects of Sn content on the mechanical properties and biological performance of these alloys processed through designed thermo-mechanical processing route are investigated...
November 11, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29156167/advancements-in-bone-fixation-utilizing-novel-biointegrative-fixation-technology
#14
REVIEW
Bob Baravarian, Tal Pnina Lindner, Ronit Merchav-Feuermann
Advancement in orthopedics have been increasing rapidly. The most important advances have been in fixation. With time, metallic hardware will begin to be replaced by materials that become one with the body. This progress will not only aid in the repair process it will allow permanent and improved reinforcement of the fixated region. Biointegrative technology is a promising new generation of materials capable of achieving this goal. Over time, it is expected that plates, screws, pins, interference screws, and even possibly joint replacements will incorporate into patients' bodies, negating the need for hardware removal and adding structure and stability to an iatrogenically weakened area...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29156144/breastfeeding-practices-and-barriers-to-implementing-the-ten-steps-to-successful-breastfeeding-in-mississippi-hospitals
#15
Amir Alakaam, Jennifer Lemacks, Kathleen Yadrick, Carol Connell, Hwanseok Winston Choi, Ray G Newman
BACKGROUND: Mississippi has the lowest rates of breastfeeding in the United States at 6 and 12 months. There is growing evidence that the rates and duration of infant breastfeeding improve after hospitals implement the Ten Steps to Successful Breastfeeding; moreover, the Ten Steps approach is considered the standard model for evaluation of breastfeeding practices in birthplaces. Research aim: This study aimed to examine the implementation level of the Ten Steps and identify barriers to implementing the Ten Steps in Mississippi hospitals...
November 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29155979/epigenetic-editing-of-the-dlg4-psd95-gene-improves-cognition-in-aged-and-alzheimer-s-disease-mice
#16
Fernando J Bustos, Estibaliz Ampuero, Nur Jury, Rodrigo Aguilar, Fahimeh Falahi, Jorge Toledo, Juan Ahumada, Jaclyn Lata, Paula Cubillos, Berta Henríquez, Miguel V Guerra, Jimmy Stehberg, Rachael L Neve, Nibaldo C Inestrosa, Ursula Wyneken, Marco Fuenzalida, Steffen Härtel, Miguel Sena-Esteves, Lorena Varela-Nallar, Marianne G Rots, Martin Montecino, Brigitte van Zundert
The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are diminished in ageing and neurodegenerative disorders, including Alzheimer's disease and Huntington's disease. The epigenetic mechanisms that (dys)regulate transcription of Dlg4/PSD95, or other plasticity genes, are largely unknown, limiting the development of targeted epigenome therapy. We analysed the Dlg4/PSD95 epigenetic landscape in hippocampal tissue and designed a Dlg4/PSD95 gene-targeting strategy: a Dlg4/PSD95 zinc finger DNA-binding domain was engineered and fused to effector domains to either repress (G9a, Suvdel76, SKD) or activate (VP64) transcription, generating artificial transcription factors or epigenetic editors (methylating H3K9)...
November 16, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29155970/cognitive-function-coping-and-depressive-symptoms-in-children-and-adolescents-with-sickle-cell-disease
#17
Kemar V Prussien, Michael R DeBaun, Janet Yarboi, Heather Bemis, Colleen McNally, Ellen Williams, Bruce E Compas
Objective: The objective of this study was to investigate the association between cognitive functioning, coping, and depressive symptoms in children and adolescents with sickle cell disease (SCD). Method: Forty-four children (M age = 9.30, SD = 3.08; 56.8% male) with SCD completed cognitive assessments measuring working memory (Wechsler Intelligence Scale for Children-Fourth Edition) and verbal comprehension (Wechsler Abbreviated Scale of Intelligence-Second Edition)...
November 16, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29155950/ensembl-2018
#18
Daniel R Zerbino, Premanand Achuthan, Wasiu Akanni, M Ridwan Amode, Daniel Barrell, Jyothish Bhai, Konstantinos Billis, Carla Cummins, Astrid Gall, Carlos García Girón, Laurent Gil, Leo Gordon, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Jimmy Kiang To, Matthew R Laird, Ilias Lavidas, Zhicheng Liu, Jane E Loveland, Thomas Maurel, William McLaren, Benjamin Moore, Jonathan Mudge, Daniel N Murphy, Victoria Newman, Michael Nuhn, Denye Ogeh, Chuang Kee Ong, Anne Parker, Mateus Patricio, Harpreet Singh Riat, Helen Schuilenburg, Dan Sheppard, Helen Sparrow, Kieron Taylor, Anja Thormann, Alessandro Vullo, Brandon Walts, Amonida Zadissa, Adam Frankish, Sarah E Hunt, Myrto Kostadima, Nicholas Langridge, Fergal J Martin, Matthieu Muffato, Emily Perry, Magali Ruffier, Dan M Staines, Stephen J Trevanion, Bronwen L Aken, Fiona Cunningham, Andrew Yates, Paul Flicek
The Ensembl project has been aggregating, processing, integrating and redistributing genomic datasets since the initial releases of the draft human genome, with the aim of accelerating genomics research through rapid open distribution of public data. Large amounts of raw data are thus transformed into knowledge, which is made available via a multitude of channels, in particular our browser (http://www.ensembl.org). Over time, we have expanded in multiple directions. First, our resources describe multiple fields of genomics, in particular gene annotation, comparative genomics, genetics and epigenomics...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155892/derivation-and-application-of-an-analytical-rock-displacement-solution-on-rectangular-cavern-wall-using-the-inverse-mapping-method
#19
Mingzhong Gao, Bin Yu, Zhiqiang Qiu, Xiangang Yin, Shengwei Li, Qiang Liu
Rectangular caverns are increasingly used in underground engineering projects, the failure mechanism of rectangular cavern wall rock is significantly different as a result of the cross-sectional shape and variations in wall stress distributions. However, the conventional computational method always results in a long-winded computational process and multiple displacement solutions of internal rectangular wall rock. This paper uses a Laurent series complex method to obtain a mapping function expression based on complex variable function theory and conformal transformation...
2017: PloS One
https://www.readbyqxmd.com/read/29155762/high-throughput-analysis-of-locomotor-behavior-in-the-drosophila-island-assay
#20
Ilse Eidhof, Michaela Fenckova, Dei M Elurbe, Bart van de Warrenburg, Anna Castells Nobau, Annette Schenck
Advances in next-generation sequencing technologies contribute to the identification of (candidate) disease genes for movement disorders and other neurological diseases at an increasing speed. However, little is known about the molecular mechanisms that underlie these disorders. The genetic, molecular, and behavioral toolbox of Drosophila melanogaster makes this model organism particularly useful to characterize new disease genes and mechanisms in a high-throughput manner. Nevertheless, high-throughput screens require efficient and reliable assays that, ideally, are cost-effective and allow for the automatized quantification of traits relevant to these disorders...
November 5, 2017: Journal of Visualized Experiments: JoVE
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