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habitual abortus

Jana Skrzypczak, Barbara Kwinecka-Dmitriew, Monika Zakrzewska, Anna Latos-Bieleńska
OBJECTIVE: Genetic factors are the most common causes of spontaneous abortions. 50% to 80% of first-trimester abortions reveal-chromosome abnormalities. Evidence for the recurrence of the same or another chromosome abnormality in the next pregnancy is scarce. THE AIM: The aim of our study was to estimate recurrence risk of abortus aneuploidy and to find out whether karyotyping of the abortus allows the prognose subsequent pregnancy outcomes. MATERIAL AND METHODS: Paraffin-embedded chorions have undergone cytogenetic examination using FISH with chromosome-specific probes...
September 2010: Ginekologia Polska
Takashi Kano, Takahide Mori, Akinori Kimura
PROBLEM: Gender ratio of live birth in humans is approximately 1.05 and males are born a slightly more, while gender ratio of fertilization should be 1.00, suggesting that female fetus might be more sensitive to abortion than male fetus during pregnancy. METHOD OF STUDY: We examined karyotype of abortuses from patients with recurrent spontaneous abortion (RSA), who had at least one live birth before or after the treatment of RSA. RESULTS: Chromosomal abnormality was not frequent (14...
September 2009: American Journal of Reproductive Immunology: AJRI
Nejat Işik, Naci Balak, Atilla Kircelli, Gökhan Göynümer, Ilhan Elmaci
In this paper we present an adult patient with the Currarino triad, associated with six habitual abortuses and chronic constipation. Our aim is to report the effectiveness of a simple surgical technique in the treatment of anterior sacral meningocele in the Currarino Syndrome. The presentation of the Currarino Syndrome in adulthood is extremely uncommon. We performed a posterior procedure via lumbar and sacral partial laminectomy and transdural ligation of the neck of the meningocele mass. There were no additional neurological deficits and no recurrence of the presacral mass over the 2-year follow up period...
July 2008: Turkish Neurosurgery
Howard Carp, Esther Guetta, Haya Dorf, David Soriano, Gad Barkai, Eyal Schiff
OBJECTIVE: To assesses chromosomal aberrations in the abortus in recurrent miscarriage, in the presence of parental chromosomal aberrations. DESIGN: Retrospective comparative cohort study. SETTING: Tertiary referral unit in university hospital. PATIENT(S): One thousand one hundred eight patients with 3-16 miscarriages before 20 weeks gestation; 113 patients with and 995 without chromosomal aberrations. INTERVENTION(S): Karyotyping by standard G-banding techniques of both parents, and of 205 abortuses collected at curettage...
February 2006: Fertility and Sterility
T V Nikitina, I N Lebedev, N N Sukhanova, S A Nazarenko
We have previously reported a high rate of tetranucleotide DNA repeat mutations, including mutations of both germline and somatic origin, in spontaneous human abortuses. To analyze in more detail mutational microsatellite (MS) variability in meiosis and its possible association with disturbed embryonic development, we have conducted a comparative study of mutation rates of a complex of 15 autosomal tetranucleotide MSs in 55 families with healthy children and in 103 families that have had spontaneous abortuses with normal karyotypes...
July 2005: Genetika
Mayumi Sugiura-Ogasawara, Yasuhiko Ozaki, Shin-ichi Sonta, Tsunehisa Makino, Kaoru Suzumori
BACKGROUND: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities. METHODS: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility...
August 2005: Human Reproduction
Pao-Lin Kuo, How-Ran Guo
OBJECTIVE: To investigate the mechanism of recurrent miscarriages in women with mosaicism of X-chromosome aneuploidies. DESIGN: Prospective case-control study. SETTING: University-based reproductive clinic housed in a medical center with genetic laboratories. PATIENT(S): Eighteen women who experienced recurrent miscarriages and had mosaicism of X-chromosome aneuploidies; two control groups, one with a balanced structural autosomal rearrangement and the other without chromosomal abnormalities...
December 2004: Fertility and Sterility
Amy E Sullivan, Robert M Silver, D Yvette LaCoursiere, T Flint Porter, D Ware Branch
OBJECTIVE: Some investigators have found a high frequency of abortus aneuploidy in women with recurrent miscarriage, suggesting the possibility of recurrent aneuploidy as a cause of recurrent miscarriage. Others contend that aneuploidy is not a cause of recurrent miscarriage. The purpose of this study was to investigate the relationship between fetal aneuploidy and recurrent miscarriage by estimating whether fetal aneuploidy is more common in patients with recurrent miscarriage than in patients with sporadic miscarriage METHODS: Recurrent miscarriage cases (n = 135) included women who had a subsequent miscarriage in which an abortus karyotype was obtained...
October 2004: Obstetrics and Gynecology
Takashi Kano, Takahide Mori, Masako Furudono, Takayoshi Kanda, Yutaka Maeda, Shogo Tsubokura, Takahisa Ushiroyama, Minoru Ueki
To investigate the possible association of recurrent spontaneous abortions (RSA) of immune aetiologies with neonatal sex differences, karyotyping of abortuses from allo-immune RSA and epidemiological studies on the sex differences of neonates from sporadic aborters was carried out. Allo-immune disorders, as diagnosed by an increased number of shared HLA class II loci and reduced blocking activity of the woman's serum in mixed lymphocyte reaction, were found almost twice (54.9%) as often as auto-immune disorders (29...
September 2004: Reproductive Biomedicine Online
A Zárate, L Basurto, M Hernández
The prevalence of thyroid dysfunctions is high in women, this female preponderance has been related with a bigger susceptibility to autoimmune abnormalities. Clinical features of thyroid disease have poor specificity and insidious onset. It is recommended to suspect thyroid pathology in the event of postpartum depression, menstrual abnormalities, amenorrhea, galactorrhea, precocious or delayed sexual development, inexplicable sterility or habitual abortus. The difficult in the clinical diagnosis is compensated by the accessibility and relative easiness of the biological diagnosis by means of the thyroid function tests, mainly the measurements of TSH and FT4 levels; thus, gynecological evaluations should be completed by obtaining thyroid function test...
May 2001: Ginecología y Obstetricia de México
No abstract text is available yet for this article.
October 1962: Journal of the Japanese Obstetrical & Gynecological Society
Mamoru Morikawa, Hideto Yamada, Emi H Kato, Shigeki Shimada, Noriaki Sakuragi, Seiichiro Fujimoto, Hisanori Minakami
OBJECTIVES: The aims of this study were to assess pregnancy outcome in relation to etiologic factors of recurrent spontaneous abortion (RSA). STUDY DESIGN: The pregnancies from consecutive 216 RSA women were assessed for live birth rates (LBR) according to etiology. The LBR in 110 pregnancies from RSA women with unexplained etiology was investigated according to various therapies. An attempt to karyotype the abortuses was made. RESULTS: Excluding pregnancies ending in abortion with abnormal karyotype, the LBR in primary recurrent spontaneous aborters (68...
July 1, 2003: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jun Mo Ahn, Do Hyeong Koo, Kye Won Kwon, You Kyoung Lee, Yong Ho Lee, Hae Hyeog Lee, Kye Hyun Nam, Kwon Hae Lee
We report an unbalanced translocation involving chromosome 2 and 7 due to a balanced reciprocal translocation 2;7 in the father. The female fetus had a partial trisomy of the long arm of chromosome 2 with a partial monosomy of distal 7q. Ultrasound at the first trimester had indicated normal fetal anatomy, including normal intracranial structures. Parental karyotypes showed a paternal balanced translocation: 46,XY,t(2;7)(q37.3;-->q34). The unbalanced translocation in the fetus resulted in trisomy for 2q37...
February 2003: Journal of Korean Medical Science
Ole B Christiansen, Bjørn Pedersen, Anni Rosgaard, Merete Husth
BACKGROUND: Previous trials of intravenous immunoglobulin (IvIg) treatment of women with recurrent miscarriage (RM) have provided diverging results. This may be due to different inclusion criteria and suboptimal treatment protocols in some trials. METHODS: According to a computer-generated list, 58 women with at least four unexplained miscarriages were randomly assigned to receive infusions of high doses of IvIg or placebo starting as soon as the pregnancy test was positive...
March 2002: Human Reproduction
M Daniely, A Aviram, H J Carp, R Shaki, G Barkai
To determine whether there is a correlation between the proportion of aneuploid cells in peripheral lymphocytes and the karyotype of the abortus in recurrent miscarriage. 40 couples with recurrent miscarriage and their abortuses were cytogenetically analyzed according to the analysis of 60 cells per proband. Women were divided into two groups according to the proportion of chromosomally abnormal cells in the abortus. Chromosomal analysis was performed using G-banding with trypsin-Giemsa in parental peripheral blood and in the abortus...
July 2001: Early Pregnancy: Biology and Medicine
D W Cramer, L A Wise
In reviewing the epidemiology of recurrent abortion (RAB), we believe it is necessary to consider the epidemiology of spontaneous abortion (SAB) as well, since it is clear that even a single pregnancy loss increases the risk for a subsequent abortion. In addition, any attempt to identify epidemiologic risk factors for SAB or RAB must deal with the fact that at least 50% of SABs are associated with genetic abnormalities. Given that most epidemiologic studies have not distinguished karyotypically abnormal abortuses, risk factors are likely to be underestimated...
2000: Seminars in Reproductive Medicine
H Carp, V Toder, A Aviram, M Daniely, S Mashiach, G Barkai
OBJECTIVE: To assess the chromosomal aberrations in the abortus in recurrent miscarriage and the live birth rate after a euploid or aneuploid miscarriage. DESIGN: Retrospective analysis. SETTING: Tertiary referral unit in university hospital. PATIENT(S): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks. INTERVENTION(S): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques...
April 2001: Fertility and Sterility
M Ogasawara, K Aoki, S Okada, K Suzumori
OBJECTIVE: To examine the frequency of chromosomal abnormalities in products of conception from patients with recurrent miscarriages in relation to the number of previous miscarriages. DESIGN: Retrospective analysis. SETTING: Nagoya City University Medical Hospital. PATIENT(S): A total of 1,309 women with a history of 2-20 consecutive first-trimester abortions. INTERVENTION(S): Chromosomal analysis performed on products of conception with use of a standard G-banding technique...
February 2000: Fertility and Sterility
A F Tsai, K A Kaufman, M A Walker, T G Karrison, R R Odem, R B Barnes, J R Scott, J R Schreiber, M D Stephenson, C Ober
To elucidate the mechanisms that facilitate tolerance at the maternal-fetal interface, we are investigating the role of genes that are involved in peripheral self-tolerance in couples with idiopathic recurrent miscarriage. CTLA-4 is a negative regulator of T-cell proliferation and has been associated with human autoimmune disease. An AT(n) polymorphism in the 3'-untranslated region (UTR) of the human gene results in AT stretches that vary in length from 16 to 46 bp. We hypothesized that long stretches of AT repeats would result in mRNA instability, and reduced fetal survival in humans...
November 1998: Journal of Reproductive Immunology
J J Stern, A D Dorfmann, A J Gutiérrez-Najar, M Cerrillo, C B Coulam
OBJECTIVE: To compare the frequency of chromosomal abnormalities in products of conception from women with and without a history of recurrent spontaneous abortion. DESIGN: Retrospective analysis of prospectively collected material. SETTING: Private practice at the Genetics and IVF Institute, Fairfax, Virginia and Grupo de Reproducción AGY Asociados, México City, México. PATIENTS: Women with (n = 94) and without (n = 130) a history of recurrent spontaneous abortion who had a spontaneous abortion between January 1, 1992 and November 1, 1994...
February 1996: Fertility and Sterility
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