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https://www.readbyqxmd.com/read/29446711/neurophysiological-adaptations-in-the-untrained-side-in-conjunction-with-cross-education-of-muscle-strength-a-systematic-review-and-meta-analysis
#1
Andrea Manca, Tibor Hortobagyi, John C Rothwell, Franca Deriu
We reviewed the evidence from randomized controlled trials (RCTs) focusing on the neurophysiological adaptations in the untrained side associated with cross-education of strength (CE) and pooled data into definite effect estimates for neurophysiological variables assessed in chronic CE studies. Furthermore, scoping directions for future research were provided to enhance the homogeneity and comparability of studies investigating the neural responses to CE. The magnitude of CE was 21.1{plus minus}18.2% (p<0...
February 15, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29410351/fibroblast-growth-factor-21-in-cardio-metabolic-disorders-a-systematic-review-and-meta-analysis
#2
Ishan Lakhani, Mengqi Gong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Sunny Hei Wong, William K K Wu, Martin C S Wong, Kwok-Leung Ong, Tong Liu, Gary Tse
BACKGROUND: Fibroblast growth factor 21 is a signalling protein involved in cell differentiation, morphogenesis, proliferation and metabolism. Recent studies have associated increased levels of FGF21 in the development of cardiovascular diseases, whereas others have reported no significant associations. Therefore, this systematic review and meta-analysis evaluated the its value in predicting the risk of cardio-metabolic disorders and mortality. METHODS: PubMed and EMBASE were searched until 5th September 2017 for studies that evaluated the roles of FGF21 levels in cardio-metabolic disorders...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29330246/the-accuracy-of-trigger-tools-to-detect-preventable-adverse-events-in-primary-care-a-systematic-review
#3
Joshua Davis, Nicole Harrington, Heather Bittner Fagan, Barbara Henry, Margot Savoy
PURPOSE: To understand the ability of trigger tools to detect preventable adverse events (pAEs) in the primary care outpatient setting using the Institute for Healthcare Improvement's (IHI) Outpatient Adverse Event Trigger Tool (IHI Tool). METHODS: The OVID MEDLINE and OVID MEDLINE In-process and non-Indexed citations databases were queried using controlled vocabulary and Medical Subject Headings related to the concepts "primary care" and "adverse events." Included articles were conducted in the outpatient setting, used at least 1 of the triggers identified in the IHI Tool, and identified pAEs of any type...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29289841/interhemispheric-motor-interactions-in-hemiparetic-children-with-perinatal-stroke-clinical-correlates-and-effects-of-neuromodulation-therapy
#4
Derek Eng, Ephrem Zewdie, Patrick Ciechanski, Omar Damji, Adam Kirton
OBJECTIVE: Brain stimulation and constraint therapy may enhance function after perinatal stroke but mechanisms are unknown. We characterized interhemispheric interactions (IHI) in hemiparetic children and explored their relationship to motor function and neuromodulation. METHODS: Forty-five hemiparetic perinatal stroke subjects aged 6-19 years completed a clinical trial of repetitive-transcranial magnetic stimulation (rTMS) and constraint therapy. Paired-pulse TMS measured IHI in cases and normal controls...
November 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29238365/spontaneous-type-1-pattern-ventricular-arrhythmias-and-sudden-cardiac-death-in-brugada-syndrome-an-updated-systematic-review-and-meta-analysis
#5
Ahmed Bayoumy, Meng-Qi Gong, Ka Hou Christien Li, Sunny Hei Wong, William Kk Wu, Guang-Ping Li, George Bazoukis, Konstantinos P Letsas, Wing Tak Wong, Yun-Long Xia, Tong Liu, Gary Tse
No abstract text is available yet for this article.
October 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29174966/pentraxin-3-as-a-marker-of-sepsis-severity-and-predictor-of-mortality-outcomes-a-systematic-review-and-meta-analysis
#6
Yee Ting Lee, Mengqi Gong, Alex Chau, Wing Tak Wong, George Bazoukis, Sunny Hei Wong, Konstantinos Lampropoulos, Yunlong Xia, Guangping Li, Martin C S Wong, Tong Liu, William K K Wu, Gary Tse
OBJECTIVES: Pentraxin-3 (PTX-3) is a multi-functional pattern recognition molecule produced by various cell types of peripheral tissues in different infections. It is raised in sepsis, but its values in predicting disease severity or mortality outcomes have been controversial. Therefore, we conducted a systematic review and meta-analysis of these associations. METHODS: PubMed and Embase were searched until July 18, 2017 for studies that evaluated the relationship between PTX-3 levels and disease severity or mortality in sepsis...
January 2018: Journal of Infection
https://www.readbyqxmd.com/read/29170328/31%C3%A2-the-quality-improvement-qip-improving-multidisciplinary-staff-engagement-with-quality-improvement-in-the-rvh-emergency-department
#7
Olly Bannon, Emma Greenwood
: In recent years the RVH Emergency Department (ED) had been under intense pressure and public scrutiny. This led to a demoralised workforce who had become disengaged with quality improvement (QI). QI projects had become an exercise in data collection with little focus on improving care for patients.Two consultants undertook training in QI and then decided to develop a QI project aiming to empower staff and embed QI as daily practice. An ED QI steering group of interested multidisciplinary members was formed and devised an improvement plan to increase staff engagement with QI...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29149456/effect-of-a-thermal-care-bundle-on-the-prevention-detection-and-treatment-of-perioperative-inadvertent-hypothermia
#8
Jed Duff, Kim Walker, Karen-Leigh Edward, Nicholas Ralph, Jo-Ann Giandinoto, Kimberley Alexander, Jeffrey Gow, John Stephenson
AIMS AND OBJECTIVES: To improve the prevention, detection, and treatment of perioperative inadvertent hypothermia (PIH) in adult surgical patients by implementing a Thermal Care Bundle. BACKGROUND: Keeping patients normothermic perioperatively prevents adverse surgical outcomes. Hypothermia leads to serious complications including increased risk of surgical bleeding, surgical site infections, and morbid cardiac events. The Thermal Care Bundle consists of three elements: 1) assess risk; 2) record temperature; and (3) actively warm...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29141696/use-of-a-trigger-tool-to-detect-adverse-drug-reactions-in-an-emergency-department
#9
Silvana Maria de Almeida, Aruana Romualdo, Andressa de Abreu Ferraresi, Giovana Roberta Zelezoglo, Alexandre R Marra, Michael B Edmond
BACKGROUND: Although there are systems for reporting adverse drug reactions (ADR), these safety events remain under reported. The low-cost, low-tech trigger tool method is based on the detection of events through clues, and it seems to increase the detection of adverse events compared to traditional methodologies. This study seeks to estimate the prevalence of adverse reactions to drugs in patients seeking care in the emergency department. METHODS: Retrospective study from January to December, 2014, applying the Institute for Healthcare Improvement (IHI) trigger tool methodology for patients treated at the emergency room of a tertiary care hospital...
November 15, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29129497/frailty-and-clinical-outcomes-in-advanced-heart-failure-patients-undergoing-left-ventricular-assist-device-implantation-a-systematic-review-and-meta-analysis
#10
Gary Tse, Mengqi Gong, Sunny Hei Wong, William K K Wu, George Bazoukis, Konstantinos Lampropoulos, Wing Tak Wong, Yunlong Xia, Martin C S Wong, Tong Liu, Jean Woo
BACKGROUND: Frailty has been identified as a risk factor for adverse clinical outcomes after cardiac intervention or surgery. However, whether it increases the risk of adverse outcomes in patients undergoing left ventricular assist device (LVAD) therapy has been controversial. Therefore, we conducted a systematic review and meta-analysis of the frailty measures and clinical outcomes of length of stay and mortality in this setting. METHODS: PubMed and Embase were searched until September 11, 2017, for studies evaluating the association between frailty and clinical outcomes in advanced heart failure patients undergoing LVAD implantation...
November 9, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29121485/distinct-modulation-of-interhemispheric-inhibitory-mechanisms-during-movement-preparation-reveals-the-influence-of-cognition-on-action-control
#11
Mark R Hinder, Rohan Puri, Sarah Kemp, Sara Waitzer, Paola Reissig, Tino Stöckel, Hakuei Fujiyama
When selecting actions based on visual warning stimuli (WS), corticospinal excitability (CSE) is initially suppressed, consistent with a neural mechanism to prevent premature release of the competing responses. Despite being implicated in between-hand movement selection and preparation, the role that interhemispheric inhibition (IHI) may play in this 'impulse control' mechanism is not known. Participants performed a warned, between-hand, choice reaction time (RT) task in which the informativeness of the WS (with regards to which hand would be required to respond) was manipulated...
October 27, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29103832/-detection-of-adverse-events-using-ihi-global-trigger-tool-during-the-adoption-of-a-risk-management-system-a-retrospective-study-over-three-years-at-a-department-for-cardiovascular-surgery-in-vienna
#12
Gerda Hoffmann-Völkl, Thomas Kästenbauer, Ursula Mück, Manfred Zottl, Wolfgang Huf, Brigitte Ettl
BACKGROUND: Several studies point in the direction that the Global Trigger Tool for Measuring Adverse Events (GTT) published by the Institute for Healthcare Improvement (IHI) is an appropriate method to detect adverse events with high specificity, sufficient sensitivity and adequate interrater and intrarater reliability. After passing a certain training period, rating teams in healthcare institutions can successfully detect and reliably compare adverse event rates on local and national levels...
November 2, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29079033/frailty-and-mortality-outcomes-after-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis
#13
Gary Tse, Mengqi Gong, Julia Nunez, Juan Sanchis, Guangping Li, Sadeq Ali-Hasan-Al-Saegh, Wing Tak Wong, Sunny Hei Wong, William K K Wu, George Bazoukis, Gan-Xin Yan, Konstantinos Lampropoulos, Adrian M Baranchuk, Lap Ah Tse, Yunlong Xia, Tong Liu, Jean Woo
BACKGROUND: Frailty has been identified as a risk factor for mortality. However, whether frailty increases mortality risk in patients undergoing percutaneous coronary intervention (PCI) has been controversial. Therefore, we conducted a systematic review and meta-analysis of the frailty measures and mortality outcomes in this setting. METHODS: PubMed and EMBASE were searched until July 23, 2017 for studies evaluating the association between frailty measures and mortality in individuals who have undergone PCI...
December 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29017777/predictive-value-of-inter-atrial-block-for-new-onset-or-recurrent-atrial-fibrillation-a-systematic-review-and-meta-analysis
#14
Gary Tse, Cheuk Wai Wong, Mengqi Gong, Wing Tak Wong, George Bazoukis, Sunny Hei Wong, Guangping Li, William K K Wu, Lap Ah Tse, Konstantinos Lampropoulos, Yunlong Xia, Tong Liu, Adrian Baranchuk
BACKGROUND AND OBJECTIVES: Inter-atrial block (IAB) is characterized by a delay of inter-atrial conduction and is defined electrocardiographically by a P-wave duration (PWD)>120ms. Several studies have implicated IAB in the development of new onset atrial fibrillation (AF), whereas others have reported no significant associations. Moreover, there has been no systematic evaluation of the predictive value of IAB in AF recurrence. Therefore, we conducted a systematic review and meta-analysis to examine whether IAB predicts new onset AF or AF recurrence...
October 3, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28979197/the-effect-of-dual-hemisphere-transcranial-direct-current-stimulation-over-the-parietal-operculum-on-tactile-orientation-discrimination
#15
Shuhei Fujimoto, Satoshi Tanaka, Ilkka Laakso, Tomofumi Yamaguchi, Noriko Kon, Takeo Nakayama, Kunitsugu Kondo, Ryo Kitada
The parietal operculum (PO) often shows ipsilateral activation during tactile object perception in neuroimaging experiments. However, the relative contribution of the PO to tactile judgment remains unclear. Here, we examined the effect of transcranial direct current stimulation (tDCS) over bilateral PO to test the relative contributions of the ipsilateral PO to tactile object processing. Ten healthy adults participated in this study, which had a double-blind, sham-controlled, cross-over design. Participants discriminated grating orientation during three tDCS and sham conditions...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28901628/total-cosine-r-to-t-for-predicting-ventricular-arrhythmic-and-mortality-outcomes-a-systematic-review-and-meta-analysis
#16
Gary Tse, Mengqi Gong, Cheuk Wai Wong, Cynthia Chan, Stamatis Georgopoulos, Yat Sun Chan, Bryan P Yan, Guangping Li, Paula Whittaker, Ana Ciobanu, Sadeq Ali-Hasan-Al-Saegh, Sunny H Wong, William K K Wu, George Bazoukis, Konstantinos Lampropoulos, Wing Tak Wong, Lap Ah Tse, Adrian M Baranchuk, Konstantinos P Letsas, Tong Liu
BACKGROUND: The total cosine R-to-T (TCRT), a vectorcardiographic marker reflecting the spatial difference between the depolarization and repolarization wavefronts, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) in different clinical settings. However, its prognostic value has been controversial. OBJECTIVE: This systematic review and meta-analysis evaluated the significance of TRCT in predicting arrhythmic and/or mortality endpoints...
September 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28887342/population-health-management-review-of-concepts-and-definitions
#17
Meghan Swarthout, Martin A Bishop
PURPOSE: The terms population health, population health improvement, and population health management are discussed. SUMMARY: A key concept in defining population health activities is clearly delineating the population(s) of focus. The Institute for Healthcare Improvement's (IHI's) Triple Aim Initiative uses the term population health management to describe the work by healthcare organizations to improve outcomes for individual patients to maximize population health...
September 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28730508/quality-improvement-initiatives-in-inflammatory-bowel-disease
#18
REVIEW
Sameer K Berry, Corey A Siegel, Gil Y Melmed
PURPOSE OF REVIEW: This article serves as an overview of several quality improvement initiatives in inflammatory bowel disease (IBD). RECENT FINDINGS: IBD is associated with significant variation in care, suggesting poor quality of care. There have been several efforts to improve the quality of care for patients with IBD. Quality improvement (QI) initiatives in IBD are intended to be patient-centric, improve outcomes for individuals and populations, and reduce costs-all consistent with "the triple aim" put forth by the Institute for Healthcare Improvement (IHI)...
August 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28690941/a-simulation-based-quality-improvement-approach-to-improve-pediatric-resident-competency-with-required-procedures
#19
Michelle Starr, Taylor Sawyer, Maya Jones, Maneesh Batra, Heather McPhillips
INTRODUCTION: Pediatric residents report a lack of confidence and competence with procedural skills at graduation. Training programs could benefit from improved approaches to target these needs. Using the Institute for Healthcare Improvement (IHI) Model for Improvement and three Plan-Do-Study-Act (PDSA) cycles, we examined the impact of a procedure simulation boot camp on self-reported procedural confidence and competence as well as the longitudinal impacts of these sequential interventions on Accreditation Council for Graduate Medical Education (ACGME) Graduating Resident Survey (GRS) results...
June 3, 2017: Curēus
https://www.readbyqxmd.com/read/28687990/cd34-negative-hematopoietic-stem-cells-show-distinct-expression-profiles-of-homing-molecules-that-limit-engraftment-in-mice-and-sheep
#20
Tomoyuki Abe, Yoshikazu Matsuoka, Yoshikazu Nagao, Yoshiaki Sonoda, Yutaka Hanazono
We and others have reported that human hematopoietic stem cells (HSCs) are also present in the CD34-negative (CD34(-)) fraction of human cord blood (CB). Here, we examined the hematopoietic engraftment potential of 13 or 18 lineage-negative (13Lin(-) or 18Lin(-)) CD34(+/-) cells from human CB in mice and sheep. Both 13Lin(-) and 18Lin(-) CD34(+) cells efficiently engrafted in mice irrespective of transplantation route, be it by tail-vein injection (TVI) or by intra-bone marrow injection (IBMI). These cells also engrafted in sheep after in utero fetal intra-hepatic injection (IHI)...
November 2017: International Journal of Hematology
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