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Gary Tse, Cynthia Chan, Mengqi Gong, Lei Meng, Jian Zhang, Xiao-Ling Su, Sadeq Ali-Hasan-Al-Saegh, Abhishek C Sawant, George Bazoukis, Yun-Long Xia, Ji-Chao Zhao, Alex Pui Wai Lee, Leonardo Roever, Martin Cs Wong, Adrian Baranchuk, Tong Liu
Background: Heart failure is a significant problem leading to repeated hospitalizations. Telemonitoring and hemodynamic monitoring have demonstrated success in reducing hospitalization rates, but not all studies reported significant effects. The aim of this systematic review and meta-analysis is to examine the effectiveness of telemonitoring and wireless hemodynamic monitoring devices in reducing hospitalizations in heart failure. Methods & Results: PubMed and Cochrane Library were searched up to 1st May 2017 for articles that investigated the effects of telemonitoring or hemodynamic monitoring on hospitalization rates in heart failure...
April 2018: Journal of Geriatric Cardiology: JGC
Ka H C Li, Mei Dong, Mengqi Gong, George Bazoukis, Ishan Lakhani, Yan Y Ting, Sunny H Wong, Guangping Li, William K K Wu, Vassilios S Vassiliou, Martin C S Wong, Konstantinos Letsas, Yimei Du, Victoria Laxton, Bryan P Yan, Yat S Chan, Yunlong Xia, Tong Liu, Gary Tse
Background and Objectives: Atrial fibrillation is a common abnormal cardiac rhythm caused by disorganized electrical impulses. AF which is refractory to antiarrhythmic management is often treated with catheter ablation. Recently a novel ablation system (nMARQ) was introduced for PV isolation. However, there has not been a systematic review of its efficacy or safety compared to traditional ablation techniques. Therefore, we conducted this meta-analysis on the nMARQ ablation system. Methods: PubMed and EMBASE were searched up until 1st of September 2017 for articles on nMARQ...
2018: Frontiers in Physiology
Maria das Dores Graciano Silva, Maria Auxiliadora Parreiras Martins, Luciana de Gouvêa Viana, Luiz Guilherme Passaglia, Renata Rezende de Menezes, João Antonio de Queiroz Oliveira, Jose Luiz Padilha da Silva, Antonio Luiz Pinho Ribeiro
AIMS: Adverse drug events (ADEs) can seriously compromise the safety and quality of care provided to hospitalized patients, requiring the adoption of accurate methods to monitor them. We sought to prospectively evaluate the accuracy of the triggers proposed by the Institute for Healthcare Improvement (IHI) for identifying ADEs. METHODS: A prospective study was conducted in a public university hospital, in 2015, with patients ≥18 years. Triggers proposed by IHI and clinical alterations suspected to be ADEs were searched daily...
June 6, 2018: British Journal of Clinical Pharmacology
Alan Peter Picarillo
As physicians continue search for ways to deliver high quality care to their patients and families, newer tools and methods are being introduced. Initially developed by manufacturing, quality improvement methods have been slowly adopted by healthcare and are now standard curriculum in medical schools. The IHI Model for Improvement allows for teams to create. model for change, test proposed changes in clinical situations, measure the results and then accept or modify the proposed changes. Additional tools such as process maps, Pareto charts, Ishikawa diagrams, and key driver diagrams provide structure and visual representation to the team during the creation and implementation of...
May 24, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Gary Tse, Mengqi Gong, Guangping Li, Sunny Hei Wong, William K K Wu, Wing Tak Wong, Leonardo Roever, Alex Pui Wai Lee, Gregory Y H Lip, Martin C S Wong, Tong Liu
BACKGROUND: Previous trials on the effectiveness of genotype-guided warfarin dosing versus conventional dosing have been inconclusive. We conducted a systematic review and meta-analysis of randomized trials comparing genotype-guided to conventional dosing strategies. METHODS: PubMed and Cochrane Library were searched until 23rd October 2017. RESULTS: A total of 76 and 94 entries were retrieved. A total of 2626 subjects in the genotype-guided dosing (mean age: 63...
April 28, 2018: British Journal of Clinical Pharmacology
Virginia Wang, Kelli Allen, Courtney H Van Houtven, Cynthia Coffman, Nina Sperber, Elizabeth P Mahanna, Cathleen Colón-Emeric, Helen Hoenig, George L Jackson, Teresa M Damush, Erika Price, Susan N Hastings
BACKGROUND: Successful implementation of new clinical programs depends on effectively establishing, reorganizing, or enhancing team structures and processes to coordinate the work of individuals who are interdependent in their tasks, manage relationships, and share responsibility for outcomes. However, a one-size-fits-all approach is rarely effective. In partnership with VA national clinical leaders and local clinical champions, the Optimizing Function and Independence VA Quality Enhancement Research Initiative program (Function QUERI) will evaluate efforts to implement team-based clinical programs for Veterans at risk for functional decline and disability...
April 20, 2018: Implementation Science: IS
John C Benson, David Nascene, Charles Truwit, Alexander M McKinney
PURPOSE: Septo-optic dysplasia is a congenital disorder consisting of optic nerve hypoplasia and absent septum pellucidum. While associated anomalies have been described, olfactory sulcus and bulb-tract hypoplasia have been scantily reported and was the focus of this study. METHODS: The picture archival and communications system and radiology information system (PACS-RIS) was searched over 15 years for patients with suspected septo-optic dysplasia (n = 41) and cerebral magnetic resonance imaging (MRI)...
April 16, 2018: Clinical Neuroradiology
Qianli Dong, Ning Li, Xiaochong Li, Zan Yuan, Dejian Xie, Xiaofei Wang, Jianing Li, Yanan Yu, Jinbin Wang, Baoxu Ding, Zhibin Zhang, Changping Li, Yao Bian, Ai Zhang, Ying Wu, Bao Liu, Lei Gong
The non-random spatial packing of chromosomes in the nucleus plays a critical role in orchestrating gene expression and genome function. Here, we present a Hi-C analysis of the chromatin interaction patterns in rice (Oryza sativa L.) at hierarchical architectural levels. We confirm that rice chromosomes occupy their own territories with certain preferential inter-chromosomal associations. Moderate compartment delimitation and extensive TADs (Topologically Associated Domains) were determined to be associated with heterogeneous genomic compositions and epigenetic marks in the rice genome...
June 2018: Plant Journal: for Cell and Molecular Biology
Vadim V Kumeiko, Yulia N Sokolnikova, Andrei V Grinchenko, Maria S Mokrina, Marina I Kniazkina
Quantitative analysis of the histopathological and immune parameters of bivalve Modiolus kurilensis collected from water areas with different level of ecotoxicological stress was performed. Significant differences between samples from polluted and non-polluted sites were revealed for total haemocyte count; percentage of agranulocytes; size and internal complexity of agranulocytes and granulocytes; phagocytic activity; percentage of NBT-positive cells; hemolytic activity and plasma protein concentration; percentage of the optical density of haemolymph major polypeptide bands at 55 kDa, 78 kDa, and 124 kDa; concretion coverage area in the kidney tubules; thickness of the tubular basement membrane; nephrocyte shape; and karyopyknosis of the kidneys; and hypervacuolisation; necrosis; karyopyknosis; haemocyte infiltration; fibrosis; and invasion of the digestive gland...
May 2018: Journal of Invertebrate Pathology
Gary Tse, Cheuk Wai Wong, Meng-Qi Gong, Lei Meng, Konstantinos P Letsas, Guang-Ping Li, Paula Whittaker, Aishwarya Bhardwaj, Abhishek C Sawant, William Kk Wu, Sunny Hei Wong, Jayaprakash Shenthar, Lap Ah Tse, Martin Cs Wong, Adrian Baranchuk, Gan-Xin Yan, Tong Liu
No abstract text is available yet for this article.
December 2017: Journal of Geriatric Cardiology: JGC
King Sum Luk, Christina Ip, Meng-Qi Gong, Sunny Hei Wong, William Kk Wu, Mei Dong, Guang-Ping Li, Ka Pang Chan, Yi-Mei Du, Tong Liu, Martin Cs Wong, David Shu Cheong Hui, Gary Tse
No abstract text is available yet for this article.
December 2017: Journal of Geriatric Cardiology: JGC
Jessica Colenutt, Bryony McCann, Michael J Knight, Elizabeth Coulthard, Risto A Kauppinen
BACKGROUND AND PURPOSE: Incomplete hippocampal inversion (IHI) is an atypical anatomical pattern presented by the hippocampus. It is associated with several neuropathological conditions and is thought to be a factor of susceptibility to hippocampal sclerosis and loss of volume. The volume loss of hippocampus is an inevitable consequence of aging, and when accelerated it is commonly considered an imaging biomarker of Alzheimer's disease dementia. METHODS: We have studied the relationship between IHI and hippocampal subfield volumes in a cohort of 60 healthy participants of 49-87 years of age...
March 25, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Andrea Manca, Tibor Hortobagyi, John C Rothwell, Franca Deriu
We reviewed the evidence from randomized controlled trials (RCTs) focusing on the neurophysiological adaptations in the untrained side associated with cross-education of strength (CE) and pooled data into definite effect estimates for neurophysiological variables assessed in chronic CE studies. Furthermore, scoping directions for future research were provided to enhance the homogeneity and comparability of studies investigating the neural responses to CE. The magnitude of CE was 21.1{plus minus}18.2% (p<0...
February 15, 2018: Journal of Applied Physiology
Ishan Lakhani, Mengqi Gong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Sunny Hei Wong, William K K Wu, Martin C S Wong, Kwok-Leung Ong, Tong Liu, Gary Tse
BACKGROUND: Fibroblast growth factor 21 is a signalling protein involved in cell differentiation, morphogenesis, proliferation and metabolism. Recent studies have associated increased levels of FGF21 in the development of cardiovascular diseases, whereas others have reported no significant associations. Therefore, this systematic review and meta-analysis evaluated the its value in predicting the risk of cardio-metabolic disorders and mortality. METHODS: PubMed and EMBASE were searched until 5th September 2017 for studies that evaluated the roles of FGF21 levels in cardio-metabolic disorders...
February 1, 2018: Metabolism: Clinical and Experimental
Joshua Davis, Nicole Harrington, Heather Bittner Fagan, Barbara Henry, Margot Savoy
PURPOSE: To understand the ability of trigger tools to detect preventable adverse events (pAEs) in the primary care outpatient setting using the Institute for Healthcare Improvement's (IHI) Outpatient Adverse Event Trigger Tool (IHI Tool). METHODS: The OVID MEDLINE and OVID MEDLINE In-process and non-Indexed citations databases were queried using controlled vocabulary and Medical Subject Headings related to the concepts "primary care" and "adverse events...
January 2018: Journal of the American Board of Family Medicine: JABFM
Derek Eng, Ephrem Zewdie, Patrick Ciechanski, Omar Damji, Adam Kirton
OBJECTIVE: Brain stimulation and constraint therapy may enhance function after perinatal stroke but mechanisms are unknown. We characterized interhemispheric interactions (IHI) in hemiparetic children and explored their relationship to motor function and neuromodulation. METHODS: Forty-five hemiparetic perinatal stroke subjects aged 6-19 years completed a clinical trial of repetitive-transcranial magnetic stimulation (rTMS) and constraint therapy. Paired-pulse TMS measured IHI in cases and normal controls...
November 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Ahmed Bayoumy, Meng-Qi Gong, Ka Hou Christien Li, Sunny Hei Wong, William Kk Wu, Guang-Ping Li, George Bazoukis, Konstantinos P Letsas, Wing Tak Wong, Yun-Long Xia, Tong Liu, Gary Tse
No abstract text is available yet for this article.
October 2017: Journal of Geriatric Cardiology: JGC
Yee Ting Lee, Mengqi Gong, Alex Chau, Wing Tak Wong, George Bazoukis, Sunny Hei Wong, Konstantinos Lampropoulos, Yunlong Xia, Guangping Li, Martin C S Wong, Tong Liu, William K K Wu, Gary Tse
OBJECTIVES: Pentraxin-3 (PTX-3) is a multi-functional pattern recognition molecule produced by various cell types of peripheral tissues in different infections. It is raised in sepsis, but its values in predicting disease severity or mortality outcomes have been controversial. Therefore, we conducted a systematic review and meta-analysis of these associations. METHODS: PubMed and Embase were searched until July 18, 2017 for studies that evaluated the relationship between PTX-3 levels and disease severity or mortality in sepsis...
January 2018: Journal of Infection
Olly Bannon, Emma Greenwood
: In recent years the RVH Emergency Department (ED) had been under intense pressure and public scrutiny. This led to a demoralised workforce who had become disengaged with quality improvement (QI). QI projects had become an exercise in data collection with little focus on improving care for patients.Two consultants undertook training in QI and then decided to develop a QI project aiming to empower staff and embed QI as daily practice. An ED QI steering group of interested multidisciplinary members was formed and devised an improvement plan to increase staff engagement with QI...
December 2017: Emergency Medicine Journal: EMJ
Jed Duff, Kim Walker, Karen-Leigh Edward, Nicholas Ralph, Jo-Ann Giandinoto, Kimberley Alexander, Jeff Gow, John Stephenson
AIMS AND OBJECTIVES: To improve the prevention, detection and treatment of perioperative inadvertent hypothermia in adult surgical patients by implementing a Thermal Care Bundle. BACKGROUND: Keeping patients normothermic perioperatively prevents adverse surgical outcomes. Hypothermia leads to serious complications including increased risk of surgical bleeding, surgical site infections and morbid cardiac events. The Thermal Care Bundle consists of three elements: (i) assess risk; (ii) record temperature; and (iii) actively warm...
March 2018: Journal of Clinical Nursing
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