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https://www.readbyqxmd.com/read/29678137/supporting-teams-to-optimize-function-and-independence-in-veterans-a-multi-study-program-and-mixed-methods-protocol
#1
Virginia Wang, Kelli Allen, Courtney H Van Houtven, Cynthia Coffman, Nina Sperber, Elizabeth P Mahanna, Cathleen Colón-Emeric, Helen Hoenig, George L Jackson, Teresa M Damush, Erika Price, Susan N Hastings
BACKGROUND: Successful implementation of new clinical programs depends on effectively establishing, reorganizing, or enhancing team structures and processes to coordinate the work of individuals who are interdependent in their tasks, manage relationships, and share responsibility for outcomes. However, a one-size-fits-all approach is rarely effective. In partnership with VA national clinical leaders and local clinical champions, the Optimizing Function and Independence VA Quality Enhancement Research Initiative program (Function QUERI) will evaluate efforts to implement team-based clinical programs for Veterans at risk for functional decline and disability...
April 20, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29663010/septo-optic-dysplasia-assessment-of-associated-findings-with-special-attention-to-the-olfactory-sulci-and-tracts
#2
John C Benson, David Nascene, Charles Truwit, Alexander M McKinney
PURPOSE: Septo-optic dysplasia is a congenital disorder consisting of optic nerve hypoplasia and absent septum pellucidum. While associated anomalies have been described, olfactory sulcus and bulb-tract hypoplasia have been scantily reported and was the focus of this study. METHODS: The picture archival and communications system and radiology information system (PACS-RIS) was searched over 15 years for patients with suspected septo-optic dysplasia (n = 41) and cerebral magnetic resonance imaging (MRI)...
April 16, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29660196/genome-wide-hi-c-analysis-reveals-extensive-hierarchical-chromatin-interactions-in-rice
#3
Qianli Dong, Ning Li, Xiaochong Li, Zan Yuan, Dejian Xie, Xiaofei Wang, Jianing Li, Yanan Yu, Jinbin Wang, Baoxu Ding, Zhibin Zhang, Changping Li, Yao Bian, Ai Zhang, Ying Wu, Bao Liu, Lei Gong
The non-random spatial packing of chromosomes in the nucleus plays critical roles in orchestrating gene expression and genome function. Here, we present a Hi-C analysis of the chromatin interaction patterns in rice (Oryza sativa L.) at hierarchical architectural levels. We confirm that rice chromosomes occupy their own territories with certain preferential inter-chromosomal associations. Moderate compartment delimitation and extensive TADs (Topologically Associated Domains) were determined to be associated with heterogeneous genomic compositions and epigenetic marks in the rice genome...
April 16, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29604260/immune-state-correlates-with-histopathological-level-and-reveals-molluscan-health-in-populations-of-modiolus-kurilensis-by-integral-health-index-ihi
#4
Vadim V Kumeiko, Yulia N Sokolnikova, Andrei V Grinchenko, Maria S Mokrina, Marina I Kniazkina
Quantitative analysis of the histopathological and immune parameters of bivalve Modiolus kurilensis collected from water areas with different level of ecotoxicological stress was performed. Significant differences between samples from polluted and non-polluted sites were revealed for total haemocyte count; percentage of agranulocytes; size and internal complexity of agranulocytes and granulocytes; phagocytic activity; percentage of NBT-positive cells; haemolytic activity and plasma protein concentration; percentage of the optical density of haemolymph major polypeptide bands at 55kDa, 78kDa, and 124kDa; concretion coverage area in the kidney tubules; thickness of the tubular basement membrane; nephrocyte shape; and karyopyknosis of the kidneys; and hypervacuolisation; necrosis; karyopyknosis; haemocyte infiltration; fibrosis; and invasion of the digestive gland...
March 28, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29581718/meta-analysis-of-t-wave-indices-for-risk-stratification-in-myocardial-infarction
#5
Gary Tse, Cheuk Wai Wong, Meng-Qi Gong, Lei Meng, Konstantinos P Letsas, Guang-Ping Li, Paula Whittaker, Aishwarya Bhardwaj, Abhishek C Sawant, William Kk Wu, Sunny Hei Wong, Jayaprakash Shenthar, Lap Ah Tse, Martin Cs Wong, Adrian Baranchuk, Gan-Xin Yan, Tong Liu
No abstract text is available yet for this article.
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29581716/a-meta-analysis-of-soluble-suppression-of-tumorigenicity-2-sst2-and-clinical-outcomes-in-pulmonary-hypertension
#6
King Sum Luk, Christina Ip, Meng-Qi Gong, Sunny Hei Wong, William Kk Wu, Mei Dong, Guang-Ping Li, Ka Pang Chan, Yi-Mei Du, Tong Liu, Martin Cs Wong, David Shu Cheong Hui, Gary Tse
No abstract text is available yet for this article.
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29575376/incomplete-hippocampal-inversion-and-its-relationship-to-hippocampal-subfield-volumes-and-aging
#7
Jessica Colenutt, Bryony McCann, Michael J Knight, Elizabeth Coulthard, Risto A Kauppinen
BACKGROUND AND PURPOSE: Incomplete hippocampal inversion (IHI) is an atypical anatomical pattern presented by the hippocampus. It is associated with several neuropathological conditions and is thought to be a factor of susceptibility to hippocampal sclerosis and loss of volume. The volume loss of hippocampus is an inevitable consequence of aging, and when accelerated it is commonly considered an imaging biomarker of Alzheimer's disease dementia. METHODS: We have studied the relationship between IHI and hippocampal subfield volumes in a cohort of 60 healthy participants of 49-87 years of age...
March 25, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29446711/neurophysiological-adaptations-in-the-untrained-side-in-conjunction-with-cross-education-of-muscle-strength-a-systematic-review-and-meta-analysis
#8
Andrea Manca, Tibor Hortobagyi, John C Rothwell, Franca Deriu
We reviewed the evidence from randomized controlled trials (RCTs) focusing on the neurophysiological adaptations in the untrained side associated with cross-education of strength (CE) and pooled data into definite effect estimates for neurophysiological variables assessed in chronic CE studies. Furthermore, scoping directions for future research were provided to enhance the homogeneity and comparability of studies investigating the neural responses to CE. The magnitude of CE was 21.1{plus minus}18.2% (p<0...
February 15, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29410351/fibroblast-growth-factor-21-in-cardio-metabolic-disorders-a-systematic-review-and-meta-analysis
#9
Ishan Lakhani, Mengqi Gong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Sunny Hei Wong, William K K Wu, Martin C S Wong, Kwok-Leung Ong, Tong Liu, Gary Tse
BACKGROUND: Fibroblast growth factor 21 is a signalling protein involved in cell differentiation, morphogenesis, proliferation and metabolism. Recent studies have associated increased levels of FGF21 in the development of cardiovascular diseases, whereas others have reported no significant associations. Therefore, this systematic review and meta-analysis evaluated the its value in predicting the risk of cardio-metabolic disorders and mortality. METHODS: PubMed and EMBASE were searched until 5th September 2017 for studies that evaluated the roles of FGF21 levels in cardio-metabolic disorders...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29330246/the-accuracy-of-trigger-tools-to-detect-preventable-adverse-events-in-primary-care-a-systematic-review
#10
Joshua Davis, Nicole Harrington, Heather Bittner Fagan, Barbara Henry, Margot Savoy
PURPOSE: To understand the ability of trigger tools to detect preventable adverse events (pAEs) in the primary care outpatient setting using the Institute for Healthcare Improvement's (IHI) Outpatient Adverse Event Trigger Tool (IHI Tool). METHODS: The OVID MEDLINE and OVID MEDLINE In-process and non-Indexed citations databases were queried using controlled vocabulary and Medical Subject Headings related to the concepts "primary care" and "adverse events...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29289841/interhemispheric-motor-interactions-in-hemiparetic-children-with-perinatal-stroke-clinical-correlates-and-effects-of-neuromodulation-therapy
#11
Derek Eng, Ephrem Zewdie, Patrick Ciechanski, Omar Damji, Adam Kirton
OBJECTIVE: Brain stimulation and constraint therapy may enhance function after perinatal stroke but mechanisms are unknown. We characterized interhemispheric interactions (IHI) in hemiparetic children and explored their relationship to motor function and neuromodulation. METHODS: Forty-five hemiparetic perinatal stroke subjects aged 6-19 years completed a clinical trial of repetitive-transcranial magnetic stimulation (rTMS) and constraint therapy. Paired-pulse TMS measured IHI in cases and normal controls...
November 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29238365/spontaneous-type-1-pattern-ventricular-arrhythmias-and-sudden-cardiac-death-in-brugada-syndrome-an-updated-systematic-review-and-meta-analysis
#12
Ahmed Bayoumy, Meng-Qi Gong, Ka Hou Christien Li, Sunny Hei Wong, William Kk Wu, Guang-Ping Li, George Bazoukis, Konstantinos P Letsas, Wing Tak Wong, Yun-Long Xia, Tong Liu, Gary Tse
No abstract text is available yet for this article.
October 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29174966/pentraxin-3-as-a-marker-of-sepsis-severity-and-predictor-of-mortality-outcomes-a-systematic-review-and-meta-analysis
#13
Yee Ting Lee, Mengqi Gong, Alex Chau, Wing Tak Wong, George Bazoukis, Sunny Hei Wong, Konstantinos Lampropoulos, Yunlong Xia, Guangping Li, Martin C S Wong, Tong Liu, William K K Wu, Gary Tse
OBJECTIVES: Pentraxin-3 (PTX-3) is a multi-functional pattern recognition molecule produced by various cell types of peripheral tissues in different infections. It is raised in sepsis, but its values in predicting disease severity or mortality outcomes have been controversial. Therefore, we conducted a systematic review and meta-analysis of these associations. METHODS: PubMed and Embase were searched until July 18, 2017 for studies that evaluated the relationship between PTX-3 levels and disease severity or mortality in sepsis...
January 2018: Journal of Infection
https://www.readbyqxmd.com/read/29170328/31-the-quality-improvement-qip-improving-multidisciplinary-staff-engagement-with-quality-improvement-in-the-rvh-emergency-department
#14
Olly Bannon, Emma Greenwood
: In recent years the RVH Emergency Department (ED) had been under intense pressure and public scrutiny. This led to a demoralised workforce who had become disengaged with quality improvement (QI). QI projects had become an exercise in data collection with little focus on improving care for patients.Two consultants undertook training in QI and then decided to develop a QI project aiming to empower staff and embed QI as daily practice. An ED QI steering group of interested multidisciplinary members was formed and devised an improvement plan to increase staff engagement with QI...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29149456/effect-of-a-thermal-care-bundle-on-the-prevention-detection-and-treatment-of-perioperative-inadvertent-hypothermia
#15
Jed Duff, Kim Walker, Karen-Leigh Edward, Nicholas Ralph, Jo-Ann Giandinoto, Kimberley Alexander, Jeff Gow, John Stephenson
AIMS AND OBJECTIVES: To improve the prevention, detection and treatment of perioperative inadvertent hypothermia in adult surgical patients by implementing a Thermal Care Bundle. BACKGROUND: Keeping patients normothermic perioperatively prevents adverse surgical outcomes. Hypothermia leads to serious complications including increased risk of surgical bleeding, surgical site infections and morbid cardiac events. The Thermal Care Bundle consists of three elements: (i) assess risk; (ii) record temperature; and (iii) actively warm...
March 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29141696/use-of-a-trigger-tool-to-detect-adverse-drug-reactions-in-an-emergency-department
#16
Silvana Maria de Almeida, Aruana Romualdo, Andressa de Abreu Ferraresi, Giovana Roberta Zelezoglo, Alexandre R Marra, Michael B Edmond
BACKGROUND: Although there are systems for reporting adverse drug reactions (ADR), these safety events remain under reported. The low-cost, low-tech trigger tool method is based on the detection of events through clues, and it seems to increase the detection of adverse events compared to traditional methodologies. This study seeks to estimate the prevalence of adverse reactions to drugs in patients seeking care in the emergency department. METHODS: Retrospective study from January to December, 2014, applying the Institute for Healthcare Improvement (IHI) trigger tool methodology for patients treated at the emergency room of a tertiary care hospital...
November 15, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29129497/frailty-and-clinical-outcomes-in-advanced-heart-failure-patients-undergoing-left-ventricular-assist-device-implantation-a-systematic-review-and-meta-analysis
#17
Gary Tse, Mengqi Gong, Sunny Hei Wong, William K K Wu, George Bazoukis, Konstantinos Lampropoulos, Wing Tak Wong, Yunlong Xia, Martin C S Wong, Tong Liu, Jean Woo
BACKGROUND: Frailty has been identified as a risk factor for adverse clinical outcomes after cardiac intervention or surgery. However, whether it increases the risk of adverse outcomes in patients undergoing left ventricular assist device (LVAD) therapy has been controversial. Therefore, we conducted a systematic review and meta-analysis of the frailty measures and clinical outcomes of length of stay and mortality in this setting. METHODS: PubMed and Embase were searched until September 11, 2017, for studies evaluating the association between frailty and clinical outcomes in advanced heart failure patients undergoing LVAD implantation...
November 9, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29121485/distinct-modulation-of-interhemispheric-inhibitory-mechanisms-during-movement-preparation-reveals-the-influence-of-cognition-on-action-control
#18
Mark R Hinder, Rohan Puri, Sarah Kemp, Sara Waitzer, Paola Reissig, Tino Stöckel, Hakuei Fujiyama
When selecting actions based on visual warning stimuli (WS), corticospinal excitability (CSE) is initially suppressed, consistent with a neural mechanism to prevent premature release of the competing responses. Despite being implicated in between-hand movement selection and preparation, the role that interhemispheric inhibition (IHI) may play in this 'impulse control' mechanism is not known. Participants performed a warned, between-hand, choice reaction time (RT) task in which the informativeness of the WS (with regards to which hand would be required to respond) was manipulated...
October 27, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29103832/-detection-of-adverse-events-using-ihi-global-trigger-tool-during-the-adoption-of-a-risk-management-system-a-retrospective-study-over-three-years-at-a-department-for-cardiovascular-surgery-in-vienna
#19
Gerda Hoffmann-Völkl, Thomas Kästenbauer, Ursula Mück, Manfred Zottl, Wolfgang Huf, Brigitte Ettl
BACKGROUND: Several studies point in the direction that the Global Trigger Tool for Measuring Adverse Events (GTT) published by the Institute for Healthcare Improvement (IHI) is an appropriate method to detect adverse events with high specificity, sufficient sensitivity and adequate interrater and intrarater reliability. After passing a certain training period, rating teams in healthcare institutions can successfully detect and reliably compare adverse event rates on local and national levels...
November 2, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29079033/frailty-and-mortality-outcomes-after-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis
#20
Gary Tse, Mengqi Gong, Julia Nunez, Juan Sanchis, Guangping Li, Sadeq Ali-Hasan-Al-Saegh, Wing Tak Wong, Sunny Hei Wong, William K K Wu, George Bazoukis, Gan-Xin Yan, Konstantinos Lampropoulos, Adrian M Baranchuk, Lap Ah Tse, Yunlong Xia, Tong Liu, Jean Woo
BACKGROUND: Frailty has been identified as a risk factor for mortality. However, whether frailty increases mortality risk in patients undergoing percutaneous coronary intervention (PCI) has been controversial. Therefore, we conducted a systematic review and meta-analysis of the frailty measures and mortality outcomes in this setting. METHODS: PubMed and EMBASE were searched until July 23, 2017 for studies evaluating the association between frailty measures and mortality in individuals who have undergone PCI...
December 1, 2017: Journal of the American Medical Directors Association
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