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JOURNAL ARTICLE
Xianying Fang, Sheng Cui, Hanbi Lee, Ji Won Min, Sun Woo Lim, Eun-Jee Oh, Chul Woo Yang, Yoo Jin Shin, Byung Ha Chung
Sensitization to HLA can result in allograft loss for kidney transplantation (KT) patients. Therefore, it is required to develop an appropriate desensitization (DSZ) technique to remove HLA-donor-specific anti-HLA antibody (DSA) before KT. The aim of this research was to investigate whether combined use of the IL-6 receptor-blocking antibody, tocilizumab (TCZ), and bone-marrow-derived mesenchymal stem cells (BM-MSCs) could attenuate humoral immune responses in an allo-sensitized mouse model developed using HLA...
January 23, 2024: International Journal of Molecular Sciences
#2
JOURNAL ARTICLE
Hari Vamsh Korukonda, Nidhita Suresh, Saranya K
Background Periodontal regeneration aims for the three-dimensional reconstruction of bone defects, and over the years, bone grafts with or without barrier membranes have provided us with promising results. Particulate bone grafts can be classified according to the source of procurement as autografts, allografts, xenografts, and alloplasts. Bioglass, an innovative alloplast that uses silica particles as a matrix incorporated with calcium and phosphorus, has been extensively used as a propitious material for bone regeneration owing to its inherent osteogenic ability and biocompatibility but presents with various disadvantages such as slow degradation rate, low mechanical strength, and fracture resistance...
December 2023: Curēus
#3
JOURNAL ARTICLE
Jonathan M Wortham, Maryam B Haddad, Rebekah J Stewart, Pallavi Annambhotla, Sridhar V Basavaraju, Scott A Nabity, Isabel S Griffin, Emily McDonald, Elizabeth M Beshearse, Marissa K Grossman, Kimberly R Schildknecht, Helene M Calvet, Chris E Keh, Jeffrey M Percak, Myron Coloma, Tambi Shaw, Peter J Davidson, Shona R Smith, Robert P Dickson, Daniel R Kaul, Annett R Gonzalez, Saroj Rai, Gretchen Rodriguez, Sandra Morris, Lisa Y Armitige, Jessica Stapleton, Michael Lacassagne, Laura R Young, Kiley Ariail, Heidi Behm, Hannah T Jordan, Magdalene Spencer, Diana M Nilsen, Brenda Montoya Denison, Marcos Burgos, Juliet M Leonard, Erick Cortes, Tyler C Thacker, Kimberly A Lehman, Adam J Langer, Lauren S Cowan, Angela M Starks, Philip A LoBue
During July 7-11, 2023, CDC received reports of two patients in different states with a tuberculosis (TB) diagnosis following spinal surgical procedures that used bone allografts containing live cells from the same deceased donor. An outbreak associated with a similar product manufactured by the same tissue establishment (i.e., manufacturer) occurred in 2021. Because of concern that these cases represented a second outbreak, CDC and the Food and Drug Administration worked with the tissue establishment to determine that this product was obtained from a donor different from the one implicated in the 2021 outbreak and learned that the bone allograft product was distributed to 13 health care facilities in seven states...
January 5, 2024: MMWR. Morbidity and Mortality Weekly Report
#4
REVIEW
Chandrashekar Annamalai, Vivek Kute, Carl Sheridan, Ahmed Halawa
INTRODUCTION: Despite its use to prevent acute rejection, lifelong immunosuppression can adversely impact long-term patient and graft outcomes. In theory, immunosuppression withdrawal is the ultimate goal of kidney transplantation, and is made possible by the induction of immunological tolerance. The purpose of this paper is to review the safety and efficacy of immune tolerance induction strategies in living-donor kidney transplantation, both chimerism-based and non-chimerism-based. The impact of these strategies on transplant outcomes, including acute rejection, allograft function and survival, cost, and immune monitoring, will also be discussed...
August 19, 2023: Transplantation Reviews
#5
Tiffany Ruan, Mustafa Naveed, Hon Vien
BACKGROUND: Bone grafting is commonly used in spine surgery to supplement or replace the need for autografts. This is harvested, prepared, and utilized predominantly for osteoconductive properties. Anterior cervical discectomy and fusion, a procedure to decompress and fuse the spine which treats herniated discs and compressed nerves, commonly uses Polyetheretherketone (PEEK) interbody filled with allograft bone matrices to reconstruct the disc space after a discectomy is performed. CASE DESCRIPTION: The presented case is one of a 57-year-old male patient who underwent an uneventful cervical 5-6 and cervical 6-7 discectomy and fusion using a PEEK interbody and bone allograft...
September 2023: N Am Spine Soc J
#6
JOURNAL ARTICLE
Rebecca A Sosa, Thomas Mone, Bita V Naini, Donald B Kohn, Elaine F Reed, Kristina Wheeler, Beatriz Campo-Fernandez, Alejandra Davila, Donald J Chaffin, Joseph DiNorcia, Fady M Kaldas, Aaron Cohen, Erik L Lum, Jeffrey L Veale, Neil M Kogut
BACKGROUND: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure; however, recipients must remain on lifelong immunosuppression, leaving them susceptible to infections and cancer. The study of transplant tolerance to prolong graft survival in the absence of immunosuppression has been restricted to recipients of living donor allografts; however, deceased donors significantly outnumber living donors. Mobilization of hematopoietic stem cells (HSCs) from the bone marrow to peripheral blood (PB) could allow PB-HSCs to be used to induce tolerance in deceased donor kidney recipients; however, a major concern is the well-known concomitant mobilization of immune cells into the liver...
August 17, 2022: Transplantation
#7
JOURNAL ARTICLE
Noah G Schwartz, Alfonso C Hernandez-Romieu, Pallavi Annambhotla, Thomas D Filardo, Sandy P Althomsons, Rebecca J Free, Ruoran Li, W Wyatt Wilson, Molly Deutsch-Feldman, Marci Drees, Emily Hanlin, Kelly White, Kimberly A Lehman, Tyler C Thacker, Scott A Brubaker, Brychan Clark, Sridhar V Basavaraju, Isaac Benowitz, Janet Burton Glowicz, Lauren S Cowan, Angela M Starks, Sapna Bamrah Morris, Philip LoBue, Rebekah J Stewart, Jonathan M Wortham, Maryam B Haddad
BACKGROUND: Mycobacterium tuberculosis transmission through solid organ transplantation has been well described, but transmission through transplanted tissues is rare. We investigated a tuberculosis outbreak in the USA linked to a bone graft product containing live cells derived from a single deceased donor. METHODS: In this outbreak report, we describe the management and severity of the outbreak and identify opportunities to improve tissue transplant safety in the USA...
November 2022: Lancet Infectious Diseases
#8
REVIEW
Emma Steijvers, Armaan Ghei, Zhidao Xia, Zx, Zx, Es, Ag, Zx, Ag
Bone grafts have traditionally come from four sources: the patients' own tissue (autograft), tissue from a living or cadaveric human donor (allograft), animal donors (xenograft) and synthetic artificial biomaterials (ceramics, cement, polymers, and metal). However, all of these have advantages and drawbacks. The most commercially successful bone grafts so far are allografts, which hold 57% of the current bone graft market; however, disease transmission and scarcity are still significant drawbacks limiting their use...
2022: Biomater Transl
#9
JOURNAL ARTICLE
Alexandre G Lellouch, Alec R Andrews, Gaelle Saviane, Zhi Yang Ng, Ilse M Schol, Marion Goutard, Amon-Ra Gama, Ivy A Rosales, Robert B Colvin, Laurent A Lantieri, Mark A Randolph, Gilles Benichou, Curtis L Cetrulo
Background: Vascularized composite allografts (VCAs) allow reconstruction of devastating injuries and amputations, yet require lifelong immunosuppression that is associated with significant morbidity. Induction of immune tolerance of VCAs would permit widespread use of these procedures. VCAs are acquired from deceased donors most likely to be fully -MHC-mismatched (in contrast to living-related renal transplant donor-recipient pairs matched at one MHC haplotype). After achieving VCA tolerance in a swine model equivalent to clinical living-related renal transplants (single-haplotype MHC mismatches: e...
2022: Frontiers in Immunology
#10
REVIEW
Nafiseh Olov, Shadab Bagheri-Khoulenjani, Hamid Mirzadeh
Tissue engineering, using a combination of living cells, bioactive molecules, and three-dimensional porous scaffolds, is a promising alternative to traditional treatments such as the use of autografts and allografts for bone and cartilage tissue regeneration. Scaffolds, in this combination, can be applied either through surgery by implantation of cell-seeded pre-fabricated scaffolds, or through injection of a solidifying precursor and cell mixture, or as an injectable cell-seeded pre-fabricated scaffold. In situ forming and pre-fabricated injectable scaffolds can be injected directly into the defect site with complex shape and critical size in a minimally invasive manner...
June 2022: Progress in Biomaterials
#11
JOURNAL ARTICLE
Laura Swoboda
INTRODUCTION: Viable placental membrane (vPM) has been shown to decrease time to healing, adverse wound events, and wound-related infections. Wound research exclusion criteria commonly exclude wound types other than diabetic foot ulcers and venous leg ulcers (VLUs), comorbidities including peripheral arterial disease (PAD) and uncontrolled diabetes mellitus (DM), and wounds with exposed bone or tendon. OBJECTIVE: This retrospective research study evaluated the clinical use and outcomes of the vPM with living mesenchymal stem cells used in chronic wound management in the community hospital outpatient department setting with the goal of comparing real-world use and outcomes of the product with use and outcomes described in the chronic wound literature...
December 2021: Wounds: a Compendium of Clinical Research and Practice
#12
JOURNAL ARTICLE
Maratib Ali, Muhammed Mubarak, Badaruddin Sahito, Shaheera Shakeel, Dileep Kumar, Rahma Rashid
To share our experience of establishing a bone bank in Pakistan, and the clinical use of these indigenously produced bone grafts. We retrospectively reviewed our experience of the procurement, processing, and storage of bone grafts at a bone bank in Karachi, Pakistan, the first bone bank to be established in a public sector hospital in Pakistan. The bone bank was established at Sindh Institute of Urology and Transplantation (SIUT), Karachi, in collaboration with Department of Orthopaedic Surgery, Dow University of Health Sciences/Civil Hospital, Karachi (CHK) in May, 2015...
August 20, 2021: Cell and Tissue Banking
#13
JOURNAL ARTICLE
Dustin R Berger, Christopher J Centeno, John D Kisiday, C Wayne McIlwraith, Neven J Steinmetz
BACKGROUND: Umbilical cord (UC) connective tissues contain plastic-adherent, colony forming unit-fibroblasts (CFU-Fs) amenable to culture expansion for potential therapeutic use. Recently, UC-derived allograft products have been made available to practitioners in orthopaedics and other specialties, by companies purporting "stem cell"-based healing. However, such marketing claims conflict with existing regulations for these human tissues, generating questions over the cellular and protein composition of current commercially available UC allograft products...
August 16, 2021: American Journal of Sports Medicine
#14
REVIEW
Yoshiko Matsuda, Takeshi Watanabe, Xiao-Kang Li
Both acute and chronic antibody-mediated allograft rejection (AMR), which are directly mediated by B cells, remain difficult to treat. Long-lived plasma cells (LLPCs) in bone marrow (BM) play a crucial role in the production of the antibodies that induce AMR. However, LLPCs survive through a T cell-independent mechanism and resist conventional immunosuppressive therapy. Desensitization therapy is therefore performed, although it is accompanied by severe side effects and the pathological condition may be at an irreversible stage when these antibodies, which induce AMR development, are detected in the serum...
2021: Frontiers in Immunology
#15
REVIEW
Ahmed A Shokeir, Saddam Hassan, Tamer Shehab, Wesam Ismail, Ismail R Saad, Abdelbasset A Badawy, Wael Sameh, Hisham M Hammouda, Ahmed G Elbaz, Ayman A Ali, Rashad Barsoum
Objective : To present the first Egyptian clinical practice guideline for kidney transplantation (KT). Methods : A panel of multidisciplinary subspecialties related to KT prepared this document. The sources of information included updates of six international guidelines, and review of several relevant international and Egyptian publications. All statements were graded according to the strength of clinical practice recommendation and the level of evidence. All recommendations were discussed by the panel members who represented most of the licensed Egyptian centres practicing KT...
January 3, 2021: Arab Journal of Urology
#16
REVIEW
Brian H Johnstone, Franka Messner, Gerald Brandacher, Erik J Woods
Induction of immune tolerance for solid organ and vascular composite allografts is the Holy Grail for transplantation medicine. This would obviate the need for life-long immunosuppression which is associated with serious adverse outcomes, such as infections, cancers, and renal failure. Currently the most promising means of tolerance induction is through establishing a mixed chimeric state by transplantation of donor hematopoietic stem cells; however, with the exception of living donor renal transplantation, the mixed chimerism approach has not achieved durable immune tolerance on a large scale in preclinical or clinical trials with other solid organs or vascular composite allotransplants (VCA)...
2021: Frontiers in Immunology
#17
REVIEW
Bharti Bisht, Ashley Hope, Anubhab Mukherjee, Manash K Paul
The need for bone grafts is tremendous, and that leads to the use of autograft, allograft, and bone graft substitutes. The biology of the bone is quite complex regarding cellular composition and architecture, hence developing a mineralized connective tissue graft is challenging. Traditionally used bone graft substitutes including metals, biomaterial coated metals and biodegradable scaffolds, suffer from persistent limitations. With the advent and rise of additive manufacturing technologies, the future of repairing bone trauma and defects seems to be optimistic...
March 5, 2021: Annals of Biomedical Engineering
#18
JOURNAL ARTICLE
Kentaro Uchida, Manabu Mukai, Masayuki Miyagi, Kensuke Fukushima, Katsufumi Uchiyama, Akiko Nakayama, Mai Matsumoto, Naonobu Takahira, Ken Urabe, Masashi Takaso, Gen Inoue
Bone banks are necessary for providing biological allografts for a series of orthopedic procedures. As nations cope with new realities driven by the 2019 coronavirus disease (COVID-19) pandemic, health-care providers, institutions, and patients share a particular concern about the effect of COVID-19 on organ donation and transplantation. Here, we describe the management of the Kitasato University Bone Bank during the state of emergency declared in response to COVID-19. Living donors received pre-operative screening by PCR, and allograft bone from COVID-19-negative donors was cryopreserved as transplantable tissues...
February 20, 2021: Cell and Tissue Banking
#19
JOURNAL ARTICLE
Vladimir Holan, Barbora Echalar, Katerina Palacka, Jan Kossl, Pavla Bohacova, Magdalena Krulova, Jana Brejchova, Petr Svoboda, Alena Zajicova
Mesenchymal stem cells (MSCs) have the ability to migrate to the site of injury or inflammation, and to contribute to the healing process. Since patients treated with MSCs are often users of analgesic drugs, to relieve their uncomfortable pain associated with the tissue disorder, there is a possibility of negative effects of these drugs on the migration of endogenous and exogenous MSCs. Therefore, we tested the impact of acute and chronic treatment with morphine on the migration and organ distribution of exogenous adipose tissue-derived MSCs in mouse models...
February 13, 2021: Stem cell reviews and reports
#20
JOURNAL ARTICLE
Ji Won Min, Yoo-Jin Shin, Hyeyoung Lee, Bo-Mi Kim, Ki Hyun Park, Kyoung Chan Doh, Tae-Min Kim, Sun Woo Lim, Chul Woo Yang, Eun-Jee Oh, Byung Ha Chung
B cell activating factor (BAFF) is a cytokine that plays a role in the survival, proliferation and differentiation of B cells. We proposed to observe the effects of BAFF inhibition on the humoral immune responses of an allosensitized mouse model using HLA.A2 transgenic mice. Wild-type C57BL/6 mice were sensitized with skin allografts from C57BL/6-Tg (HLA-A2.1)1Enge/J mice and were treated with anti-BAFF monoclonal antibody (mAb) (named Sandy-2) or control IgG1 antibody. HLA.A2-specific IgG was reduced in BAFF-inhibited mice compared to the control group (Δ-13...
January 16, 2021: International Journal of Molecular Sciences
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