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Venous leg ulcer

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https://www.readbyqxmd.com/read/29037357/topical-timolol-promotes-healing-of-chronic-leg-ulcer
#1
Bindhiya Thomas, John Sajan Kurien, Toney Jose, Sansho Elavumkal Ulahannan, Sandeep Abraham Varghese
BACKGROUND: Chronic ulcers are a common problem, with chronic diabetic and venous ulcers forming a large proportion. This is the first case-control study to assess the effect of topical timolol on healing of chronic venous and chronic diabetic ulcers. METHODS: The study included 60 patients with chronic leg ulcers. The ulcers in the study group (n = 30) were treated with topical 0.5% timolol maleate solution along with antibiotics and dressings; those in the control group (n = 30) received only antibiotics and dressings...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29037356/three-dimensional-digital-imaging-is-as-accurate-and-reliable-to-measure-leg-ulcer-area-as-transparent-tracing-with-digital-planimetry
#2
Guillaume Chaby, Catherine Lok, Jean Philippe Thirion, Arnaud Lucien, Patricia Senet
OBJECTIVE: An accurate and reliable method for measuring venous leg ulcer (VLU) area is important in assessing treatment effects. The new three-dimensional (3D) LifeViz digital imaging system (QuantifiCare S.A., Valbonne, France) combines a compact, easy to use stereovision camera and image management software to provide 3D medical images. The aim of this prospective study was to investigate whether the 3D LifeViz digital imaging system could be considered a suitable alternative to manual transparent wound tracing for the measurement of VLU area and 4-week healing rates...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29037354/baseline-factors-affecting-closure-of-venous-leg-ulcers
#3
William A Marston, William J Ennis, John C Lantis, Robert S Kirsner, Robert D Galiano, Wolfgang Vanscheidt, Sabine A Eming, Marcin Malka, D Innes Cargill, Jaime E Dickerson, Herbert B Slade
OBJECTIVE: The objective of this study was to characterize factors associated with closure of venous leg ulcers (VLUs) in a pooled analysis of subjects from three randomized clinical trials. METHODS: Closure of VLUs after treatment with HP802-247, an allogeneic living cell therapy consisting of growth-arrested human keratinocytes and fibroblasts, vs standard therapy with compression bandaging was evaluated in three phase 3 clinical trials of similar design. Two trials enrolled subjects with VLUs ranging from 2 cm(2) to 12 cm(2) in area with 12-week treatment periods; the third trial enrolled subjects with VLUs between >12 cm(2) and ≤36 cm(2) with a 16-week treatment period...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29024419/a-multicentre-randomised-controlled-trial-evaluating-the-efficacy-of-dehydrated-human-amnion-chorion-membrane-epifix%C3%A2-allograft-for-the-treatment-of-venous-leg-ulcers
#4
Christian Bianchi, Shawn Cazzell, Dean Vayser, Alexander M Reyzelman, Hasan Dosluoglu, Gregory Tovmassian
A randomised, controlled, multicentre clinical trial was conducted to evaluate the efficacy of dehydrated human amnion/chorion membrane (EpiFix) allograft as an adjunct to multilayer compression therapy for the treatment of non-healing full-thickness venous leg ulcers. We randomly assigned 109 subjects to receive EpiFix and multilayer compression (n = 52) or dressings and multilayer compression therapy alone (n = 57). Patients were recruited from 15 centres around the USA and were followed up for 16 weeks...
October 11, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28985441/effects-and-associations-of-nutrition-in-patients-with-venous-leg-ulcers-a-systematic-review
#5
REVIEW
Georgina A Barber, Carolina D Weller, Simone J Gibson
AIMS: To identify the associations and effects of nutritional characteristics and interventions on ulcer outcomes in adult patients with venous leg ulcers. BACKGROUND: Venous leg ulcers are the most prevalent type of lower limb ulcer, however little evidence exists regarding the relationship between nutritional status and ulcer healing. DESIGN: A systematic search of English language articles was conducted using the Cochrane Collaboration Handbook for Systematic Reviews of Interventions...
October 6, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28976834/managing-real-world-venous-leg-ulcers-with-fetal-bovine-acellular-dermal-matrix-a-single-centre-retrospective-study
#6
J A Paredes, S Bhagwandin, Polanco T, J C Lantis
OBJECTIVE: As compression treatment offers moderate improvement, especially to recurrent venous leg ulcers (VLUs), several alternative therapies using cellular based and/or tissue-derived products (CTPs) have emerged from bovine, porcine, and equine sources. Our aim was to look at the effect of a CTP in 'real-life' VLUs. METHODS: This study looked at complex patients with chronic, large wounds in a single-centre retrospective review. All patients were treated with fetal bovine acellular dermal matrix (FBADM) for VLUs at our outpatient urban wound care programme...
October 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28976826/hydrosurgery-as-a-safe-and-efficient-debridement-method-in-a-clinical-wound-unit
#7
M Ferrer-Sola, H Sureda-Vidal, J Altimiras-Roset, E Fontsere-Candell, V Gonzalez-Martinez, J Espaulella-Panicot, V Falanga, M Otero-Viñas
OBJECTIVE: Hydrosurgical debridement allows removal of non-viable tissue, preserving healthy tissues. This study was designed to analyse whether hydrosurgery, used in a clinical wounds unit, is an effective and safe method that may reduce debridement time. METHODS: Patients' wounds had the following characteristics: wounds with devitalised tissue needing rapid debridement, wounds with cavities, or non-healing wounds. Hydrosurgical debridement uses a pressurised stream of saline (0...
October 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28976341/preliminary-results-of-a-topically-applied-bacteria-specific-antibiotic-gel-to-improve-wound-healing
#8
Caitlin S Zarick, Elizabeth A Benkert, Noah G Oliver, John S Steinberg, Karen K Evans, Christopher E Attinger, Zinnia M Rocha, Paul J Kim
INTRODUCTION: Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden. OBJECTIVE: This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy...
September 26, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28964388/-health-related-quality-of-life-in-chronic-venous-disease-systematic-literature-review
#9
N Zenati, J L Bosson, S Blaise, P Carpentier
OBJECTIVE: Excepting life-threatening situations, improvement of health-related quality-of-life is the main therapeutic goal in chronic disease. The purpose of this review was to study the different ways of assessing Quality-of-Life (QoL) in patients with chronic venous disease (CVD) (CEAP classes C3 to C6). METHODS: A literature search was conducted with three databases: MEDLINE, WEB OF SCIENCE and COCHRANE LIBRARY in order to identify articles with the PRISMA reporting guidelines...
October 2017: J Med Vasc
https://www.readbyqxmd.com/read/28960514/a-systematic-review-of-qualitative-research-into-people-s-experiences-of-living-with-venous-leg-ulcers
#10
REVIEW
P Phillips, E Lumley, R Duncan, A Aber, H B Woods, G L Jones, J A Michaels
AIM: To systematically identify, evaluate and synthesise qualitative research that examined the symptoms and health related quality of life themes that are important from the perspective of patients with venous leg ulceration. BACKGROUND: Venous leg ulceration is a common chronic condition; the symptoms and associated treatments have a negative effect on health-related quality of life. Qualitative research methods can provide insight into the personal experiences of patients with venous leg ulceration...
September 27, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28958579/-needs-assessment-to-improve-the-applicability-and-methodological-quality-of-a-german-s3-guideline
#11
Marion Burckhardt, Cristina Hoffmann, Brigitte Nink-Grebe, Sylvia Sänger
BACKGROUND: Clinical practice guidelines can change the practice in healthcare only if their recommendations are implemented in a comprehensive way. The German S3 guideline "Local Therapy of Chronic Wounds in Patients with Peripheral Vascular Disease, Chronic Venous Insufficiency, and Diabetes" will be updated in 2017. The emphasis here is on the guideline's validity, user-friendliness and implementation into practice. Therefore, the aim was to identify the improvements required in regard to the guideline's methods and content presentation...
September 25, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28956692/cyanoacrylate-adhesive-embolization-and-sclerotherapy-for-primary-varicose-veins
#12
Krishna Prasad Bellam Premnath, Binu Joy, Vijayakumar Akondi Raghavendra, Ajith Toms, Teena Sleeba
Various treatment methods are available for the treatment of varicose veins, and there has been a recent surge in the usage of cyanoacrylate glue for treating varicose veins. Purpose To investigate the technical possibility, efficiency and safety of cyanoacrylate adhesive embolization and sclerotherapy using commonly available n-butyl cyanoacrylate glue for the treatment of primary varicose veins due to great saphenous vein reflux with or without incompetent perforators. Materials and Methods One hundred forty-five limbs of 124 patients with varicose veins due to great saphenous vein reflux were subjected to cyanoacrylate adhesive embolization and sclerotherapy - adhesive embolization of great saphenous vein in the thigh and perforators using cyanoacrylate followed by sclerotherapy of any residual varicose veins in the leg...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28943804/treatment-in-the-home-setting-with-intermittent-pneumatic-compression-for-a-woman-with-chronic-leg-ulcers-a-case-report
#13
Katrina Young, Harrison Ng Chok, Lesley Wilkes
BACKGROUND: Intermittent Pneumatic Compression (IPC) is shown to improve the healing rate of Venous Leg Ulcers (VLU) in the hospital setting. The current Australian "Gold Standard" treatment according to the Australian and New Zealand Wound Management Associations' (AWMA) Prevention & Management of Venous Leg Ulcer guidelines is compression, generally in the form of bandaging then progressing to hosiery once wounds are healed to prevent recurrence. This is recommended in conjunction with other standards of wound management including; nutrition, exercise, client education and addressing underlying pathophysiology and psychosocial factors...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#14
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28923443/-leg-ulcer-ankle-brachial-pressure-index-and-the-role-of-the-nurse
#15
REVIEW
Maria Consolación Cano Sanchez
The measurement of the ankle-brachial pressure index is essential for the treatment of leg ulcers. In the framework of the imminent implementation of advanced practices in France, nurses specifically trained in wound care and healing could be authorised to take and interpret this measurement. Venous compression techniques could therefore be adapted more precisely to the needs of the patients.
September 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28922511/reliability-and-measurement-error-of-digital-planimetry-for-the-measurement-of-chronic-venous-leg-ulcers
#16
Michael Stacey, Steven Phillips, Forough Farrokhyar, Jillian M Swaine
Area measurements of a chronic wound are the gold standard outcome measure to determine if a wound is on a healing or non-healing trajectory. The use of digital planimetry can provide increased accuracy in measuring wound area however it is important to know the reliability and measurement error of these devices when used by multiple assessors. The aim of this study is to determine the within rater, between rater, and standard error of measurement of a digital planimetry device. Wound area in 42 patients was measured weekly for 12 weeks by two different raters, with each rater measuring the wound 10 times per visit...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28914681/randomized-controlled-trial-comparing-collagen-oxidized-regenerated-cellulose-silver-to-standard-of-care-in-the-management-of-venous-leg-ulcers
#17
Breda M Cullen, Thomas E Serena, Molly C Gibson, Robert J Snyder, Jason R Hanft, Raphael A Yaakov
OBJECTIVE: To assess healing outcomes in venous leg ulcers (VLUs) treated with a combination of collagen, oxidized regenerated cellulose, and silver in conjunction with standard of care (SOC; intervention group) compared with SOC alone (control group). Standard of care included ADAPTIC nonadhering dressing (Acelity, San Antonio, Texas) and compression. DESIGN AND SETTING: Randomized controlled trial that followed patients in 3 US facilities for 12 weeks or until complete healing...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28914679/reliability-of-a-skin-diagnostic-device-in-assessing-hydration-and-erythema
#18
Koh Huimin, Alexandra M Rowledge, Caroline J Borzdynski, Charne Miller, Nicoletta Frescos, Gayle McKenzie, Elizabeth Perry, William McGuiness
OBJECTIVE: To examine the reliability of a skin diagnostic device, the SD202 (Courage+Khazaka GmBH, Cologne, Germany), in assessing hydration and erythema of periwound skin and pressure injury-prone areas. DESIGN: Intrarater reliabilities from 3 cross-sectional and prospective studies are reported. SETTING AND PARTICIPANTS: Patients attending an outpatient, nurse-led wound dressing clinic (n = 16), a podiatrist-led high-risk foot clinic (n = 17), and residents (n = 38) at a single residential aged-care facility...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28905242/poly-n-acetyl-glucosamine-snag-enhances-early-rotator-cuff-tendon-healing-in-a-rat-model
#19
C A Nuss, J Huegel, J F Boorman-Padgett, D S Choi, S N Weiss, J Vournakis, L J Soslowsky
Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. The purpose of this study was to investigate the healing and analgesic properties of sNAG in a rat rotator cuff injury and repair model. 144 adult male Sprague-Dawley rats underwent a transection and repair of their left supraspinatus tendons...
September 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28880752/evaluation-of-osteopontin-expression-in-chronic-wounds-a-potential-prognostic-and-therapeutic-biomarker
#20
S Chimento, V Billero, L Cavallin, M Romanelli, M Nadji, P Romanelli
OBJECTIVE: Osteopontin (OPN) is abundantly expressed during tissue repair, acting as a powerful chemokine that recruits inflammatory cells such as neutrophils, macrophages, and Langerhans cells. The role of OPN in chronic wounds has not been explored. In this study, we assess the expression levels of OPN in chronic wounds to assess its potential contribution to the exacerbated inflammation seen in chronic ulcers, which is thought to contribute to poor healing. METHODS: This retrospective study included archived biopsies of chronic wounds from several aetiologies...
September 1, 2017: Journal of Wound Care
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