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https://www.readbyqxmd.com/read/28719758/reflections-on-patient-centered-care-from-the-perspective-of-a-young-otolaryngologist
#1
Nausheen Jamal
It is now well recognized that patient engagement in health care is a key factor in improving satisfaction; however, it is also critical if we are to improve the health outcomes of our patients, as well as the economic and quality outcomes of our health system. Medicine, though, has traditionally resisted a culture of patient-centered or patient-controlled care. What follow are the reflections of one otolaryngologist on the importance and challenges of making the transition to patient-centered care.
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28719672/the-effects-of-ice-on-methane-hydrate-nucleation-a-microcanonical-molecular-dynamics-study
#2
Zhengcai Zhang, Guang-Jun Guo
Although ice powders are widely used in gas hydrate formation experiments, the effects of ice on hydrate nucleation and what happens in the quasi-liquid layer of ice are still not well understood. Here, we used high-precision constant energy molecular dynamics simulations to study methane hydrate nucleation from vapor-liquid mixtures exposed to the basal, prismatic, and secondary prismatic planes of hexagonal ice (ice Ih). Although no significant difference is observed in hydrate nucleation processes for these different crystal planes, it is found, more interestingly, that methane hydrate can nucleate either on the ice surface heterogeneously or in the bulk solution phase homogeneously...
July 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28719563/what-s-new-in-musculoskeletal-infection-update-across-orthopaedic-subspecialties
#3
Antonia F Chen, Arvind D Nana, Sandra B Nelson, Alex McLaren
No abstract text is available yet for this article.
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28719393/restrictions-and-limitations-after-pelvic-floor-surgery-what-s-the-evidence
#4
Miles Murphy
PURPOSE OF REVIEW: A common concern regarding pelvic floor surgery is the relatively high risk of recurrence. In an effort to minimize this risk, many surgeons instruct their patients to avoid certain activities during the healing process so as not to damage the repair before proper healing has occurred. However, many of these restrictions have been historically based on little to no hard evidence. The purpose of this review is to present the latest evidence-based recommendations regarding restrictions and limitations after pelvic floor surgery...
July 17, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28719388/what-is-new-in-managing-patients-with-food-allergy-almost-everything
#5
Brian Schroer, Jaclyn Bjelac, Mandy Leonard
PURPOSE OF REVIEW: This review aims to describe current concepts in managing patients with food allergy. There have been many recent advances in the management of patients with IgE-mediated reactions to food, including diagnosis, prevention, management, and ongoing research in the field. Food allergy is increasing in prevalence and may be life threatening. This review aims to highlight changes in recommended practice when diagnosing and managing patients with food allergy. RECENT FINDINGS: Early introduction of highly allergenic foods, particularly peanut, has been shown to decrease the risk for development of food allergy in patients who are at elevated risk...
July 14, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28719385/prevention-of-hemolytic-disease-of-the-fetus-and-newborn-what-have-we-learned-from-animal-models
#6
Yoelys Cruz-Leal, Danielle Marjoram, Alan H Lazarus
PURPOSE OF REVIEW: This review aims to highlight recent advances in our understanding of how anti-red blood cell (RBC) antibodies prevent erythrocyte immunization with an emphasis on new murine models. RECENT FINDINGS: New murine models with clinically relevant human erythrocyte antigens have been used to understand the alloimmunization process and its inhibition. The search to elucidate the mechanism of action of IgG-mediated inhibition of erythrocyte alloimmunization has provided new evidence in support of a potential role for epitope masking, immune deviation and/or antigen modulation in this process...
July 17, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28719368/change-is-in-the-air-what-you-need-to-know-about-pharmacy-ventilation-under-united-states-pharmacopeia-800
#7
Cheryl Laniewicz
On July 1, 2018, United States Pharmacopeia <800> takes effect in those states that adopt it, and the discussion within this article may be applicable to those states that develop their own standards. United States Pharmacopeia <800> changes requirements for storage and compounding of hazardous drugs. The new requirements have important implications for air management and ventilation in some pharmacies. This article discusses how United States Pharmacopeia <800> compares to United States Pharmacopeia <797>, how the changes impact room ventilation and pressurization requirements, and how high-performance airflow control systems that ensure compliance and safety are impacted...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28719299/conventional-wisdom-versus-actual-outcomes-challenges-in-the-conduct-of-an-ebola-vaccine-trial-in-liberia-during-the-international-public-health-emergency
#8
Gregg S Larson, Beth R Baseler, Marie L Hoover, Jerome F Pierson, Jemee K Tegli, Melvin P Johnson, Mark W S Kieh, Laura A McNay, Wissedi Sio Njoh
Clinical trials are challenging endeavors. Planning and implementing an investigational vaccine trial in Liberia, in the midst of an Ebola virus disease (EVD) epidemic that World Health Organization classified a public health emergency of international concern, presented extraordinary challenges. Normally, years of preparation and a litany of tasks lay the groundwork for a successful, randomized, blinded, placebo-controlled trial focused on safety and efficacy. Difficult research settings, unpredictable events, and other unique circumstances can add complexity...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719289/what-is-a-hotspot-anyway
#9
Justin Lessler, Andrew S Azman, Heather S McKay, Sean M Moore
AbstractThe importance of spatial clusters, or "hotspots," in infectious disease epidemiology has been increasingly recognized, and targeting hotspots is often seen as an important component of disease-control strategies. However, the precise meaning of "hotspot" varies widely in current research and policy documents. Hotspots have been variously described as areas of elevated incidence or prevalence, higher transmission efficiency or risk, or higher probability of disease emergence. This ambiguity has led to confusion and may result in mistaken inferences regarding the best way to target interventions...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719261/more-evidence-on-the-effects-of-deworming-what-lessons-can-we-learn
#10
Kevin Croke, Eric Hsu, Michael Kremer
No abstract text is available yet for this article.
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719193/relationships-between-atmospheric-transport-regimes-and-pcb-concentrations-in-air-at-zeppelin-spitsbergen
#11
Sandy Ubl, Martin Scheringer, Konrad Hungerbühler
Polychlorinated biphenyls (PCBs) are persistent hazardous chemicals that are still detected in the atmosphere and other environmental media although their production has been banned for several decades. At the long-term monitoring site, Zeppelin at Spitsbergen, different PCB congeners have been continuously measured for more than a decade. However, it is not clear what factors determine the seasonal and inter-annual variability of different (lighter vs. heavier) PCB congeners. To investigate the influence of atmospheric transport patterns on PCB-28 and PCB-101 concentrations at Zeppelin, we applied the Lagrangian Particle Dispersion Model FLEXPART and calculated "footprints'' that indicate the potential source regions of air arriving at Zeppelin...
July 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28719141/neonatal-infection-produces-significant-changes-in-immune-function-with-no-associated-learning-deficits-in-juvenile-rats
#12
Brittany F Osborne, Jasmine I Caulfield, Samantha A Solomotis, Jaclyn M Schwarz
The current experiments examined the impact of early-life immune activation and a subsequent mild immune challenge with lipopolysaccharide (LPS; 25µg/kg) on hippocampal-dependent learning, proinflammatory cytokine expression in the brain, and peripheral immune function in juvenile male and female rats at P24, an age when hippocampal-dependent learning and memory first emerges. Our results indicate that neonatal infection did not produce learning deficits in the hippocampal-dependent context pre-exposure facilitation effect (CPFE) paradigm in juvenile males and females, contrary to what has been observed in adults...
July 18, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28719092/what-is-targeted-proteomics-a-concise-revision-of-targeted-acquisition-and-targeted-data-analysis-in-mass-spectrometry
#13
Eva Borràs, Eduard Sabidó
No abstract text is available yet for this article.
July 18, 2017: Proteomics
https://www.readbyqxmd.com/read/28719048/developmental-mechanisms-of-intervertebral-disc-and-vertebral-column-formation
#14
REVIEW
Lisa Y Lawson, Brian D Harfe
The vertebral column consists of repeating units of ossified vertebrae that are adjoined by fibrocartilagenous intervertebral discs. These structures form from the embryonic notochord and somitic mesoderm. In humans, congenital malformations of the vertebral column include scoliosis, kyphosis, spina bifida, and Klippel Feil syndrome. In adulthood, a common malady affecting the vertebral column includes disc degeneration and associated back pain. Indeed, recent reports estimate that low back pain is the number one cause of disability worldwide...
July 18, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28719040/discovering-long-term-potentiation-ltp-recollections-and-reflections-on-what-came-after
#15
REVIEW
Terje Lømo
Chance events led me to a lifelong career in scientific research. They paved the way for being the first to see long-term potentiation of synaptic efficiency (LTP) in Per Andersen's lab in Oslo in 1966. Here I describe my way to this discovery and the experiments with Tim Bliss in 1968-1969 that led to Bliss and Lømo, 1973. Surprisingly, we later failed to reproduce these results. I discuss possible reasons for this failure, which made us both leave LTP research, in my case for good, in Tim's case for several years...
July 18, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28718986/the-effect-of-selection-history-on-extinction-risk-during-severe-environmental-change
#16
Josianne Lachapelle, Nick Colegrave, Graham Bell
Environments rarely remain the same over time, and populations are therefore frequently at risk of going extinct when changes are significant enough to reduce fitness. While many studies have investigated what attributes of the new environments and of the populations experiencing these changes will affect their probability of going extinct, limited work has been directed toward determining the role of population history on the probability of going extinct during severe environmental change. Here we compare the extinction risk of populations with a history of selection in a benign environment, to populations with a history of selection in one or two stressful environments...
July 18, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28718969/child-and-family-related-predictors-of-psychological-outcomes-in-children-adopted-from-abroad-what-is-the-role-of-caregiver-time
#17
Niina Rita, Marko Elovainio, Hanna Raaska, Pekka Lahti-Nuuttila, Jaakko Matomäki, Jari Sinkkonen, Helena Lapinleimu
International adoptees need to cope with stressful transitions and to develop secure attachment with their caregivers at the same time. Although most children adopted from abroad adjust fine, they are at increased risk of psychological problems. We investigated whether both child and family-related factors are associated with later psychological problems and whether the length of time spent at home after adoption before daycare moderates these associations among internationally adopted children in Finland (FinAdo, Finnish Adoption Study)...
August 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28718928/accessing-support-and-empowerment-online-the-experiences-of-individuals-with-diabetes
#18
Ellen Brady, Julia Segar, Caroline Sanders
CONTEXT: The use of the internet for health information by those with long-term conditions is growing. It has been argued that this represents a form of empowerment by patients, as it enables them to control the content and flow of the information available to them. To explore this, the use of online discussion groups by those with diabetes was examined. METHOD: Semi-structured interviews were conducted with 21 participants with type 1 and 2 diabetes and analysed using thematic analysis...
July 18, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28718864/-cognitive-behavioral-group-therapy-addressing-fear-of-progression-in-cancer-out-patients
#19
Bärbel Rudolph, Alexander Wünsch, Peter Herschbach, Andreas Dinkel
Fear of progression (FoP) is an appropriate, rational response to the real threat of cancer and its treatments. However, patients experiencing elevated, dysfunctional levels of FoP often feel severely distressed and are in need of treatment. We previously conducted a (partly-)randomized controlled study with cancer patients undergoing in-patient rehabilitation and showed that a brief, four-session cognitive-behavioral group therapy significantly reduced dysfunctional FoP. In this report, we describe the adaption of the cognitive-behavioral group therapy program for use with cancer out-patients...
June 29, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28718795/novel-molecular-insights-about-lactobacillar-sortase-dependent-piliation
#20
REVIEW
Ingemar von Ossowski
One of the more conspicuous structural features that punctuate the outer cell surface of certain bacterial Gram-positive genera and species is the sortase-dependent pilus. As these adhesive and variable-length protrusions jut outward from the cell, they provide a physically expedient and useful means for the initial contact between a bacterium and its ecological milieu. The sortase-dependent pilus displays an elongated macromolecular architecture consisting of two to three types of monomeric protein subunits (pilins), each with their own specific function and location, and that are joined together covalently by the transpeptidyl activity of a pilus-specific C-type sortase enzyme...
July 18, 2017: International Journal of Molecular Sciences
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