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https://www.readbyqxmd.com/read/28532047/porous-chitosan-microspheres-for-application-as-quick-in-vitro-and-in-vivo-hemostat
#1
Jixiang Li, Xiaowei Wu, Yanqing Wu, Zonghao Tang, Xun Sun, Meng Pan, Yufeng Chen, Juanjuan Li, Rongdong Xiao, Zhengchao Wang, Haiqing Liu
Controlling massive hemorrhage is of great importance to lower transfusional medical cost, and to reduce death and mobility rate in battlefield and civilian accidents. We reported the fabrication of porous chitosan microspheres (CSMS) with tunable surface pore size by microemulsion combined with thermally induced phase separation technique, and its application as a quick hemostat. Their hemostatic property was characterized by blood clotting kinetics, adherence interaction between red blood cells/platelets and CSMS, in vitro and in vivo hemostasis by rat tail amputation and liver laceration models, and histological analysis...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531998/reline-assisted-green-and-facile-synthesis-of-fluorapatite-nanoparticles
#2
Mohammad Karimi, Majid Rastegar Ramsheh, Seyed Mohammad Ahmadi, Mohammad Reza Madani, Mehdi Shamsi, Reyhaneh Reshadi, Farahnaz Lotfi
A fast, simple and sustainable method based on choline chloride-urea deep eutectic solvent (known as Reline) was employed to synthesize nanosized fluorapatite (FA) particles. Using XRD, FESEM, TEM, EDS, and FTIR, the formation of FA nanoparticles with average crystal size of ~34nm, percent crystallinity of 93%, particle size of ~45nm, and high crystal, elemental, and structural purity was confirmed. The MTT cytotoxicity assay endorsed the non-toxicity of as-synthesized FA nanoparticles. The good biocompatibility, osteogenity and mineralization ability of as-synthesized FA nanoparticles were confirmed by Alizarin red staining, Acridine orange staining and ALP activity tests...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531915/bone-marrow-stem-cells-anti-liver-fibrosis-potency-inhibition-of-hepatic-stellate-cells-activity-and-extracellular-matrix-deposition
#3
Ervina Julien Sitanggang, Radiana Dhewayani Antarianto, Sri Widia A Jusman, Jeanne Adiwinata Pawitan, Ahmad Aulia Jusuf
Transplantation of bone marrow derived stem cells (BMSCs) has been reported inhibits liver fibrosis. Several in vitro studies by co-culturing BMSCs and hepatic stellate cells (HSCs) indirectly or directly in 2D models showed inhibition of HSC as the key player in liver fibrosis. In this study, we investigated direct effect of BMSCs on HSCs by co-culturing BMSCs and HSCs in 3D model as it represents the liver microenvironment with intricate cell-cell and cell-matrix interactions. Primary isolated rat HSCs and BMSCs were directly co-cultured at 1:1 ratio with hanging drop method...
May 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28531842/a-highly-selective-long-wavelength-fluorescent-probe-for-hydrazine-and-its-application-in-living-cell-imaging
#4
Yuanqiang Hao, Yintang Zhang, Kehong Ruan, Fanteng Meng, Ting Li, Jinsheng Guan, Lulu Du, Peng Qu, Maotian Xu
A highly selective long-wavelength turn-on fluorescent probe has been developed for the detection of N2H4. The probe was prepared by conjugation the tricyanofuran-based D-π-A system with a recognizing moiety of acetyl group. In the presence of N2H4, the probe can be effectively hydrazinolysized and produce a turn-on fluorescent emission at 610nm as well as a large red-shift in the absorption spectrum corresponding to a color change from yellow to blue. The sensing mechanism was confirmed by HPLC, MS, UV-vis, emission spectroscopic and theoretical calculation studies...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28531816/predicted-phototoxicities-of-carbon-nano-material-by-quantum-mechanical-calculations
#5
Don Betowski
The purpose of this research was to develop a predictive model for the phototoxicity potential of carbon nanomaterials (fullerenols and single-walled carbon nanotubes). This model is based on the quantum mechanical (ab initio) calculations on these carbon-based materials and comparison of the triplet excited states of these materials to published work relating phototoxicity of polynuclear aromatic hydrocarbons (PAH) to their predictive triplet excited state energy. A successful outcome will add another tool to the arsenal of predictive methods for the U...
March 31, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28531811/synthesis-of-novel-indole-derivatives-as-promising-dna-binding-agents-and-evaluation-of-antitumor-and-antitopoisomerase-i-activities
#6
Elizabeth Almeida Lafayette, Sinara Mônica Vitalino de Almeida, Renata Virginia Cavalcanti Santos, Jamerson Ferreira de Oliveira, Cezar Augusto da Cruz Amorim, Rosali Maria Ferreira da Silva, Maira Galdino da Rocha Pitta, Ivan da Rocha Pitta, Ricardo Olimpio de Moura, Luiz Bezerra de Carvalho Júnior, Moacyr Jesus Barreto de Melo Rêgo, Maria do Carmo Alves de Lima
Molecules bearing indole nucleus present diverse biological properties such as antitumor and anti-inflammatory activities that can be associated both to DNA and protein interactions. This study focused on the synthesis of new indole derivatives with thiazolidines and imidazolidine rings condensed as side chains as well as the evaluation of their ability to interact with the DNA and antitumor and topoisomerase inhibition activities. All derivatives were successfully synthesized and their structures were elucidated by mass spectrometry (MS), infrared (IR), spectroscopy (1)H NMR, (13)C NMR, COSY (1)H-(1)H and HSQC (1)H-(13)C...
May 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28531658/co-plantation-of-aquatic-macrophytes-typha-angustifolia-and-paspalum-scrobiculatum-for-effective-treatment-of-textile-industry-effluent
#7
Vishal V Chandanshive, Niraj R Rane, Asif S Tamboli, Avinash R Gholave, Rahul V Khandare, Sanjay P Govindwar
Field treatment of textile industry effluent was carried out in constructed drenches (91.4m×1.2m×0.6m; 65.8m(3)) planted independently with Typha angustifolia, Paspalum scrobiculatum and their co-plantation (consortium-TP). The in situ treatment of effluent by T. angustifolia, P. scrobiculatum and consortium-TP was found to decrease ADMI color value by 62, 59 and 76%, COD by 65, 63 and 70%, BOD by 68, 63 and 75%, TDS by 45, 39 and 57%, and TSS by 35, 31 and 47%, respectively within 96h. Heavy metals such as arsenic, cadmium, chromium and lead were also removed up to 28-77% after phytoremediation...
May 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28531363/beneficial-effect-of-enriched-air-nitrox-on-bubble-formation-during-scuba-diving-an-open-water-study
#8
Anne-Kathrin Brebeck, Andreas Deussen, Ursula Range, Costantino Balestra, Sinclair Cleveland, Jochen D Schipke
Bubble formation during scuba diving might induce decompression sickness. This prospective randomised and double-blind study included 108 advanced recreational divers (38 females). Fifty-four pairs of divers, 1 breathing air and the other breathing nitrox28 undertook a standardised dive (24 ± 1 msw; 62 ± 5min) in the Red Sea. Venous gas bubbles were counted (Doppler) 30-<45 min (early) and 45-60 min (late) post-dive at jugular, subclavian and femoral sites. Only 7% (air) vs. 11% (air28®) (n.s.) were bubble-free after a dive...
May 21, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28531352/conformational-complexity-in-the-lh2-antenna-of-the-purple-sulfur-bacterium-allochromatium-vinosum-revealed-by-hole-burning-spectroscopy
#9
Adam Kell, Mahboobe Jassas, Khem Acharya, Kirsty Hacking, Richard J Cogdell, Ryszard J Jankowiak
This work discusses the protein conformational complexity of the B800-850 LH2 complexes from the purple sulfur bacterium Allochromatium vinosum, focusing on the spectral characteristics of the B850 chromophores. Low-temperature B850 absorption and the split B800 band shift blue and red, respectively, at elevated temperatures, revealing isosbestic points. The latter indicates the presence of two (unresolved) conformations of B850 bacteriochlorophylls (BChls), referred to as conformations 1 and 2, and two conformations of B800 BChls, denoted as B800R and B800B...
May 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28531281/standard-vs-intensified-management-of-heart-failure-to-reduce-healthcare-costs-results-of-a-multicentre-randomized-controlled-trial
#10
P A Scuffham, J Ball, J D Horowitz, C Wong, P J Newton, P Macdonald, J McVeigh, A Rischbieth, N Emanuele, M J Carrington, C M Reid, Y K Chan, S Stewart
Aims: To determine if an intensified form of heart failure management programme (INT-HF-MP) based on individual profiling is superior to standard management (SM) in reducing health care costs during 12-month follow-up (primary endpoint). Methods and results: A multicentre randomized trial involving 787 patients (full analysis set) discharged from four tertiary hospitals with chronic HF who were randomized to SM (n = 391) or INT-HF-MP (n = 396). Mean age was 74 ± 12 years, 65% had HF with a reduced ejection fraction (31...
May 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28531236/psychosine-enhances-the-shedding-of-membrane-microvesicles-implications-in-demyelination-in-krabbe-s-disease
#11
Ludovic D'Auria, Cory Reiter, Emma Ward, Ana Lis Moyano, Michael S Marshall, Duc Nguyen, Giuseppe Scesa, Zane Hauck, Richard van Breemen, Maria I Givogri, Ernesto R Bongarzone
In prior studies, our laboratory showed that psychosine accumulates and disrupts lipid rafts in brain membranes of Krabbe's disease. A model of lipid raft disruption helped explaining psychosine's effects on several signaling pathways important for oligodendrocyte survival and differentiation but provided more limited insight in how this sphingolipid caused demyelination. Here, we have studied how this cationic inverted coned lipid affects the fluidity, stability and structure of myelin and plasma membranes...
2017: PloS One
https://www.readbyqxmd.com/read/28531198/a-real-time-traffic-control-method-for-the-intersection-with-pre-signals-under-the-phase-swap-sorting-strategy
#12
Yiming Bie, Zhiyuan Liu, Yinhai Wang
To deal with the conflicts between left-turn and through traffic streams and increase the discharge capacity, this paper addresses the pre-signal which is implemented at a signalized intersection. Such an intersection with pre-signal is termed as a tandem intersection. For the tandem intersection, phase swap sorting strategy is deemed as the most effective phasing scheme in view of some exclusive merits, such as easier compliance of drivers, and shorter sorting area. However, a major limitation of the phase swap sorting strategy is not considered in previous studies: if one or more vehicle is left at the sorting area after the signal light turns to red, the capacity of the approach would be dramatically dropped...
2017: PloS One
https://www.readbyqxmd.com/read/28531196/co-inheritance-of-glucose-6-phosphate-dehydrogenase-deficiency-mutations-and-hemoglobin-e-in-a-kachin-population-in-a-malaria-endemic-region-of-southeast-asia
#13
Zeshuai Deng, Fang Yang, Yao Bai, Lijun He, Qing Li, Yanrui Wu, Lan Luo, Hong Li, Limei Ma, Zhaoqing Yang, Yongshu He, Liwang Cui
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and hemoglobin E (HbE, β26 Glu-Lys) are two common red cell disorders in Southeast Asia. G6PD deficiency produces hemolytic anemia, which can be triggered by certain drugs or infections. HbE is asymptomatic or is manifested as microcytic, minimally hemolytic anemia. The association between G6PD deficiency and HbE is little understood. This study aimed to investigate G6PD deficiency and HbE in a Kachin ethnic group in the China-Myanmar border area. G6PD enzyme activity was measured using a quantitative G6PD assay, G6PD variants genotyped by the SNaPshot assay, and an HbE gene mutation identified by an amplification refractory mutation system and subsequently confirmed by using a reverse dot blot hybridization assay from 100 unrelated individuals in the study area...
2017: PloS One
https://www.readbyqxmd.com/read/28531179/the-gingival-vein-as-a-minimally-traumatic-site-for-multiple-blood-sampling-in-guinea-pigs-and-hamsters
#14
Mariana Valotta Rodrigues, Simone Oliveira de Castro, Cynthia Zaccanini de Albuquerque, Vânia Gomes de Moura Mattaraia, Marcelo Larami Santoro
Laboratory animals are still necessary in scientific investigation and vaccine testing, but while novel methodological approaches are not available for their replacement, the search for new, humane, easy, and painless methods is necessary to diminish their stress and pain. When multiple blood samples are to be collected from hamsters and guinea pigs, the number of available venipuncture sites-which are greatly diminished in these species in comparison with other rodents due to the absence of a long tail-, harasses animal caregivers and researchers...
2017: PloS One
https://www.readbyqxmd.com/read/28531134/improving-video-segmentation-by-fusing-depth-cues-and-the-visual-background-extractor-vibe-algorithm
#15
Xiaoqin Zhou, Xiaofeng Liu, Aimin Jiang, Bin Yan, Chenguang Yang
Depth-sensing technology has led to broad applications of inexpensive depth cameras that can capture human motion and scenes in three-dimensional space. Background subtraction algorithms can be improved by fusing color and depth cues, thereby allowing many issues encountered in classical color segmentation to be solved. In this paper, we propose a new fusion method that combines depth and color information for foreground segmentation based on an advanced color-based algorithm. First, a background model and a depth model are developed...
May 21, 2017: Sensors
https://www.readbyqxmd.com/read/28530825/effect-of-wood-aging-on-wine-mineral-composition-and-87sr-86sr-isotopic-ratio
#16
Ayse Deniz Kaya, Raúl Bruno de Sousa, António Sérgio Curvelo-Garcia, Jorge Manuel Ricardo-da-Silva, Sofia Catarino
Evolution of mineral composition and wine strontium isotopic ratio 87Sr/86Sr (Sr IR) during wood aging were investigated. A red wine was aged in stainless steel tanks with French oak staves (Quercus sessiliflora Salisb.), with three industrial scale replicates. Sampling was carried out after 30, 60 and 90 days of aging, and the wines evaluated in terms of general analysis, phenolic composition, total polysaccharides, multi-element composition and Sr IR. Li, Be, Mg, Al, Sc, Ti, V, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Rb, Sr, Y, Zr, Mo, Sb, Cs, Ba, Pr, Nd, Sm, Eu, Dy, Ho, Er, Yb, Lu, Tl, Pb elements and 87Sr/86Sr were determined by quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS), Na, K, Ca and Fe by flame atomic absorption spectrometry (FAAS)...
May 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28530810/seleniranium-ions-undergo-%C3%AF-ligand-exchange-via-an-associative-mechanism-in-the-gas-phase
#17
Shea Fern Lim, Benjamin Leigh Harris, George N Khairallah, Evan John Bieske, Philippe Maître, Gabriel da Silva, Brian D Adamson, Michael S Scholz, Neville J A Coughlan, Richard A J O'Hair, Michael Rathjen, Daniel Stares, Jonathan M White
Collision-induced dissociation mass spectrometry of the ammonium ions 4a and 4b results in the formation of the seleniranium ion 5, the structure and purity of which was verified using gas phase infra-red spectroscopy coupled to mass spectrometry, and gas phase ion-mobility measurements. Ion-molecule reactions between the ion 5 (m/z = 261) and cyclopentene, cyclohexene, cycloheptene and cyclooctene, resulted in the formation of the seleniranium ions 7 (m/z = 225), 6 (m/z = 239), 8 (m/z = 253), and 9 (m/z = 267) respectively...
May 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28530803/red-phosphorus-nano-dots-on-reduced-graphene-oxide-as-a-flexible-and-ultra-fast-anode-for-sodium-ion-batteries
#18
Yihang Liu, Anyi Zhang, Chenfei Shen, Qingzhou Liu, Xuan Cao, Yuqiang Ma, Liang Chen, Christian Lau, Tian-Chi Chen, Fei Wei, Chongwu Zhou
Sodium-ion batteries offer an attractive option for potential low cost and large scale energy storage due to the earth abundance of sodium. Red phosphorus is considered as a high capacity anode for sodium-ion batteries with a theoretical capacity of 2596 mAh/g. However, similar to silicon in lithium-ion batteries, several limitations such as large volume expansion upon sodiation/de-sodiation and low electronic conductance have severely limited the performance of red phosphorus anodes. In order to address the above challenges, we have developed a method to deposit red phosphorus nano-dots densely and uniformly onto reduced graphene oxide sheets (P@RGO) to minimize the sodium ion diffusion length and the sodiation/de-sodiation stresses, and the RGO network also serves as electron pathway and creates free space to accommodate the volume variation of phosphorus particles...
May 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28530759/a-dual-emission-probe-to-detect-moisture-and-water-in-organic-solvents-based-on-green-tb-3-post-coordinated-metal-organic-frameworks-with-red-carbon-dots
#19
Jing-Xing Wu, Bing Yan
Using p-phenylenediamine as a precursor, p-carbon dots (p-CDs) with strong red-light emission were encapsulated into a metal-organic framework (MOF) followed by introduction of green light-emitting Tb(3+) to form a two-color light-emitting hybrid (Tb(3+)@p-CDs/MOF). The as-prepared fluorescent-functionalized MOF not only maintained the excellent optical properties of p-CDs and Tb(3+) to give strong emission, but also had good chemical and physical properties. The chosen p-CDs were aggregated readily in water, which led to only very weak photoluminescence, whereas the opposite effect was noted in the organic solvents ethanol, dimethylformamide and cyclopropane...
May 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28530733/photophysical-properties-singlet-oxygen-generation-efficiency-and-cytotoxic-effects-of-aloe-emodin-as-a-blue-light-photosensitizer-for-photodynamic-therapy-in-dermatological-treatment
#20
Lixin Zang, Huimin Zhao, Xueyu Ji, Wenwu Cao, Zhiguo Zhang, Peisong Meng
Conventional photodynamic therapy (PDT) uses red light for deeper penetration. A natural compound, aloe emodin (AE) with anticancer and photosensitising capabilities, excited by blue light, is proposed to treat superficial diseases. The photophysical properties and singlet oxygen quantum yield (ΦΔ) of AE, as well as the cytotoxic effects of AE on human cells, were investigated. The absorption and emission spectra of AE were analyzed. The ΦΔ of AE was measured by a relative method. In order to study the relationship between ΦΔ and the oxygen concentration, the dependence of ΦΔ on the oxygen concentration was investigated...
May 22, 2017: Photochemical & Photobiological Sciences
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