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https://www.readbyqxmd.com/read/28823032/luminescent-benzothiazole-based-fluorophore-of-anisidine-scaffoldings-a-turn-on-fluorescent-probe-for-al-3-and-hg-2-ions
#1
Gargi Dhaka, Navneet Kaur, Jasvinder Singh
A new anisidine possessing benzothiaozle-based chemosensor (1) has been designed and synthesized. The chemosensor 1 was designed to provide hard base environment for ratiometric detection of comparatively less studied Al(3+) ions. In CH3CN, the fluorescence spectra of chemosensor 1 red shifted from 368 to 430 nm with addition of Al(3+) and Hg(2+) ions; while Cu(2+) ions caused quenching of emission intensity of 1. These differential changes observed with Al(3+) and Cu(2+) ions addition enabled chemosensor 1 to construct "NOR" and "TRANSFER" logic gates...
August 19, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28822717/searching-for-monocular-microsaccades-a-red-hering-of-modern-eye-trackers
#2
Marcus Nyström, Richard Andersson, Diederick C Niehorster, Ignace Hooge
Despite early reports and the contemporary consensus on microsaccades as purely binocular phenomena, recent work has proposed not only the existence of monocular microsaccades, but also that they serve functional purposes. We take a critical look at the detection of monocular microsaccades from a signal perspective, using raw data and a state-of-the-art, video-based eye tracker. In agreement with previous work, monocular detections were present in all participants using a standard microsaccade detection algorithm...
August 16, 2017: Vision Research
https://www.readbyqxmd.com/read/28822568/effects-of-lipopolysaccharide-on-the-proliferation-and-osteogenic-differentiation-of-stem-cells-from-the-apical-papilla
#3
Veera Lertchirakarn, Panuroot Aguilar
INTRODUCTION: Stem cells from the apical papilla (SCAPs) were suggested as the stem cell source in regenerative endodontic procedures. However, bone and/or cementum-like structure were observed in root canals. Lipopolysaccharide (LPS) in infected root canals might alter SCAPs' osteogenic differentiation pattern. The objectives of this study were to investigate the effects of LPS on SCAPs' proliferation and osteogenic differentiation. METHODS: The mesenchymal stem cell characteristics of SCAPs were confirmed...
August 16, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28822320/bio-active-maneonenes-and-isomaneonene-from-the-red-alga-laurencia-obtusa
#4
Nahed O Bawakid, Walied M Alarif, Ali I Ismail, Mohamed E El-Hefnawy, Khalid O Al-Footy, Sultan S Al-Lihaibi
Three previously undescribed compounds, maneonenes and isomaneonene derivatives; in addition to five known compounds, two cuparene, one chamigrene, and two cis-maneonenes were isolated from the Red Sea red alga Laurencia obtusa. The chemical structures of all unknown metabolites were characterized employing spectroscopic methods and then were further confirmed by single crystal X-ray analysis. Jeddahenyne A has C-5-C-12 etheric linkage and C-13-C-14 carbon-carbon double bond; Jeddahenyne B has in addition to the aforementioned etheric linkage a C-13 carbonyl function and absence of halogenation, unusual features for the maneonenes while 12-debromo-12-methoxy isomaneonene A shows unrecorded methoxylation at C-12...
August 16, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28822212/comparison-of-start-and-salt-triage-methodologies-to-reference-standard-definitions-and-to-a-field-mass-casualty-simulation
#5
Salvatore Silvestri, Adam Field, Neal Mangalat, Tory Weatherford, Christopher Hunter, Zoe McGowan, Zachary Stamile, Trevor Mattox, Tanner Barfield, Aarian Afshari, George Ralls, Linda Papa
OBJECTIVES: We compared Sort, Assess, Lifesaving Intervention, Treatment/Transport (SALT) and Simple Triage and Rapid Treatment (START) triage methodologies to a published reference standard, and evaluated the accuracy of the START method applied by emergency medical services (EMS) personnel in a field simulation. DESIGN: Simulated mass casualty incident (MCI). Paramedics trained in START triage assigned each victim to green (minimal), yellow (delayed), red (immediate), or black (dead) categories...
January 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28822190/-effect-of-pinostrobin-chalcone-on-adipogenic-differentiation-of-mesenchymal-stem-cell-c3h10t1-2
#6
Wei-Peng Huang, Yan-Fen Huang, Jian-Zhen Chen, Bo Jin, Jia-Ning Tan, Zhi-Shan Ding
Chalcones is a flavonoid wildly presented in many herbs. It has the effect to inhibit cells adipogenic differentiation. In order to study the effect of pinostrobin chalcone extracted and isolated from leaves of hickoryes on the adipogenic differentiation of murine embryonic mesenchymal stem cell (C3H10T1/2), MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)- 2H-tetrazolium] method was used to detect the cell proliferation; adipogenic differentiation was characterized by oil red O staining and isopropanol extraction; the triglyceride content was detected by GAP-PAP enzyme method; and the C3H10T1/2 cell differentiation into adipocytes was also examined by the mRNA and protein expression of PPARγ, C/EBPα and FABP4 by RT-PCR and Western blot respectively...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28821981/modifiable-factors-and-esophageal-cancer-a-systematic-review-of-published-meta-analyses
#7
REVIEW
Clara Castro, Bárbara Peleteiro, Nuno Lunet
There are marked differences in the etiology of the major histological types of esophageal cancer (EC)-squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids...
August 18, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28821823/highly-efficient-up-conversion-luminescence-in-er-3-yb-3-co-doped-na5lu9f32-single-crystals-by-vertical-bridgman-method
#8
Shinan He, Haiping Xia, Jianli Zhang, Yongsheng Zhu, Baojiu Chen
Er(3+)/Yb(3+) co-doped Na5Lu9F32 single crystals with different concentrations of Yb(3+) ions were prepared to investigate their phase structure, up-conversion (UC) properties and mechanism of UC luminescence by Bridgman method. Under 980 nm near-infrared (NIR) excitation, three sharp UC emission bands topping at green ~525 nm, ~548 nm and red ~669 nm were obtained in Er(3+)/Yb(3+) doped Na5Lu9F32 single crystals which are attributing to the transitions of (2)H11/2 → (4)I15/2, (4)S3/2 → (4)I15/2 and (4)F9/2 → (4)I15/2, respectively...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821818/an-essential-role-for-tagln2-in-phagocytosis-of-lipopolysaccharide-activated-macrophages
#9
Hye-Ran Kim, Hyun-Su Lee, Kyung-Sik Lee, In Duk Jung, Min-Sung Kwon, Chang-Hyun Kim, Seong-Min Kim, Myung-Han Yoon, Yeong-Min Park, Sang-Myeong Lee, Chang-Duk Jun
Activated macrophages have a greater ability of phagocytosis against pathogens that is mediated by large-scale actin rearrangement. However, molecular machineries that conduct this task have not been fully identified. Here, we demonstrate an unanticipated role of TAGLN2, a 22-kDa actin-binding protein, in Toll-like receptor (TLR)-stimulated phagocytosis. TAGLN2 was greatly induced in macrophages in response to lipopolysaccharide (LPS), a ligand for TLR4, partly via the NF-κB pathway. TAGLN2-deficient macrophages (TAGLN2 (-/-)) showed defective phagocytic functions of IgM- and IgG-coated sheep red blood cells as well as bacteria...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821806/longitudinal-study-of-changes-in-%C3%AE-%C3%AE-t-cells-and-cd4-t-cells-upon-asymptomatic-malaria-infection-in-indonesian-children
#10
Sanne E de Jong, Vera E R Asscher, Linda J Wammes, Aprilianto E Wiria, Firdaus Hamid, Erliyani Sartono, Taniawati Supali, Hermelijn H Smits, Adrian J F Luty, Maria Yazdanbakhsh
Both γδ T cells and CD4(+) T cells have been implicated in immunity to malaria, but their association with natural gain or loss of infection has not been studied before. Therefore, we followed up asymptomatic children living in an area endemic for malaria in Indonesia for 21 months. The percentage of γδ T cells was related to both current and previous infection, with higher percentages in infected than uninfected children and declining after infections resolve. Infected children also had higher levels of Th1 and Th17 cells, lower levels of CD25(Hi) FOXP3(+) regulatory T cells (Tregs), but similar levels of Th2 cells as compared to uninfected children...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821732/light-color-importance-for-circadian-entrainment-in-a-diurnal-octodon-degus-and-a-nocturnal-rattus-norvegicus-rodent
#11
Maria Angeles Bonmati-Carrion, Beatriz Baño-Otalora, Juan Antonio Madrid, Maria Angeles Rol
The central circadian pacemaker (Suprachiasmatic Nuclei, SCN) maintains the phase relationship with the external world thanks to the light/dark cycle. Light intensity, spectra, and timing are important for SCN synchronisation. Exposure to blue-light at night leads to circadian misalignment that could be avoided by using less circadian-disruptive wavelengths. This study tests the capacity of a diurnal Octodon degus and nocturnal Rattus norvegicus to synchronise to different nocturnal lights. Animals were subjected to combined red-green-blue lights (RGB) during the day and to: darkness; red light (R); combined red-green LED (RG) lights; and combined red-green-violet LED (RGV) lights during the night...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821594/lazy-genes-mediate-the-effects-of-gravity-on-auxin-gradients-and-plant-architecture
#12
Takeshi Yoshihara, Edgar P Spalding
A rice mutant led to the discovery of a plant-specific LAZY1 protein that controls the orientation of shoots. Arabidopsis thaliana possesses six LAZY genes having spatially distinct expression patterns. Branch angle phenotypes previously associated with single LAZY genes were here studied in roots and shoots of single and higher-order atlazy mutants. The results identify the major contributors to root and shoot branch angles and gravitropic behavior of seedling hypocotyls and primary roots. AtLAZY1 is the principal determinant of inflorescence branch angle...
August 18, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28821525/point-of-care-washing-of-allogeneic-red-blood-cells-for-the-prevention-of-transfusion-related-respiratory-complications-war-prc-a-protocol-for-a-multicenter-randomised-clinical-trial-in-patients-undergoing-cardiac-surgery
#13
Matthew A Warner, Ian J Welsby, Phillip J Norris, Christopher C Silliman, Sarah Armour, Erica D Wittwer, Paula J Santrach, Laurie A Meade, Lavonne M Liedl, Chelsea M Nieuwenkamp, Brian Douthit, Camille M van Buskirk, Phillip J Schulte, Rickey E Carter, Daryl J Kor
INTRODUCTION: The transfusion-related respiratory complications, transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO), are leading causes of transfusion-related morbidity and mortality. At present, there are no effective preventive strategies with red blood cell (RBC) transfusion. Although mechanisms remain incompletely defined, soluble biological response modifiers (BRMs) within the RBC storage solution may play an important role. Point-of-care (POC) washing of allogeneic RBCs may remove these BRMs, thereby mitigating their impact on post-transfusion respiratory complications...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821520/preclinical-medical-students-understandings-of-academic-and-medical-professionalism-visual-analysis-of-mind-maps
#14
Janusz Janczukowicz, Charlotte E Rees
INTRODUCTION: Several studies have begun to explore medical students' understandings of professionalism generally and medical professionalism specifically. Despite espoused relationships between academic (AP) and medical professionalism (MP), previous research has not yet investigated students' conceptualisations of AP and MP and the relationships between the two. OBJECTIVES: The current study, based on innovative visual analysis of mind maps, therefore aims to contribute to the developing literature on how professionalism is understood...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28821457/spontaneous-mutation-of-dock7-results-in-lower-trabecular-bone-mass-and-impaired-periosteal-expansion-in-aged-female-misty-mice
#15
Phuong T Le, Kathleen A Bishop, David E Maridas, Katherine J Motyl, Daniel J Brooks, Kenichi Nagano, Roland Baron, Mary L Bouxsein, Clifford J Rosen
Misty mice (m/m) have a loss of function mutation in Dock7 gene, a guanine nucleotide exchange factor, resulting in low bone mineral density, uncoupled bone remodeling and reduced bone formation. Dock7 has been identified as a modulator of osteoblast number and in vitro osteogenic differentiation in calvarial osteoblast culture. In addition, m/m exhibit reduced preformed brown adipose tissue innervation and temperature as well as compensatory increase in beige adipocyte markers. While the low bone mineral density phenotype is in part due to higher sympathetic nervous system (SNS) drive in young mice, it is unclear what effect aging would have in mice homozygous for the mutation in the Dock7 gene...
August 15, 2017: Bone
https://www.readbyqxmd.com/read/28821336/a-randomized-clinical-trial-of-red-blood-cell-transfusion-triggers-in-cardiac-surgery
#16
Colleen G Koch, Daniel I Sessler, Edward J Mascha, Joseph F Sabik, Liang Li, Andra I Duncan, Nicole M Zimmerman, Eugene H Blackstone
BACKGROUND: Class I evidence supporting a threshold for transfusion in the cardiac surgical setting is scarce. We randomly allocated patients to a transfusion hematocrit trigger of 24% versus 28% to compare morbidity, mortality, and resource use. METHODS: From March 2007 to August 2014, two centers randomly assigned 722 adults undergoing coronary artery bypass graft surgery or valve procedures to a 24% hematocrit trigger (n = 363, low group) or 28% trigger (n = 354, high group)...
August 16, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28821248/morphology-of-the-snake-spectacle-reflects-its-evolutionary-adaptation-and-development
#17
Mari-Ann Otkjaer Da Silva, Steffen Heegaard, Tobias Wang, Jacob Thorup Gade, Christian Damsgaard, Mads Frost Bertelsen
BACKGROUND: Covering the eye of all snakes is a transparent integumental structure known as the spectacle. In order to determine variations in spectacle thickness among species, the spectacles of 217 alcohol-preserved museum specimens of 44 species belonging to 14 different families underwent optical coherence tomography (OCT) to measure spectacular thickness. Multivariable analyses were made to determine whether family, activity period (diurnal/nocturnal) and habitat (arboreal/terrestrial/fossorial/aquatic) influenced spectacle thickness...
August 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28821189/y-chromosome-markers-for-the-red-fox
#18
Halie M Rando, Jeremy T Stutchman, Estelle R Bastounes, Jennifer L Johnson, Carlos A Driscoll, Christina S Barr, Lyudmila N Trut, Benjamin N Sacks, Anna V Kukekova
The de novo assembly of the red fox (Vulpes vulpes) genome has facilitated the development of genomic tools for the species. Efforts to identify the population history of red foxes in North America have previously been limited by a lack of information about the red fox Y-chromosome sequence. However, a megabase of red fox Y-chromosome sequence was recently identified over 2 scaffolds in the reference genome. Here, these scaffolds were scanned for repeated motifs, revealing 194 likely microsatellites. Twenty-three of these loci were selected for primer development and, after testing, produced a panel of 11 novel markers that were analyzed alongside 2 markers previously developed for the red fox from dog Y-chromosome sequence...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28821139/charge-functionalized-and-mechanically-durable-composite-cryogels-from-q-nfc-and-cs-for-highly-selective-removal-of-anionic-dyes
#19
Yufei Chen, Jing Ru, Biyao Geng, Haiying Wang, Congcong Tong, Chungui Du, Shengchun Wu, Hongzhi Liu
A composite cryogel was prepared from quaternized nanofibrillated cellulose (Q-NFC) and chitosan (CS) through a combination of freeze-drying and cross-linking with epichlorohydrin. The specific surface area of the composite cryogel was approximately two times that of Q-NFC cryogel. And the composite cryogel exhibited superior adsorption properties of anionic dyes than either the Q-NFC or CS cryogel controls. The adsorption isotherm well fitted the Langmuir model with the maximum theoretical adsorption capacity up to 473...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821124/the-characterization-selenylation-and-antidiabetic-activity-of-mycelial-polysaccharides-from-catathelasma-ventricosum
#20
Yuntao Liu, Yuxian You, Yiwen Li, Lan Zhang, Leilei Yin, Yingbin Shen, Cheng Li, Hong Chen, Shujuan Chen, Bin Hu, Daiwen Chen
The mycelial polysaccharide from Catathelasma ventricosum (mCVP-1S) was found to be a heteropolysaccharide with an average size of 230kDa composed mainly of β-glucopyranosyl residues. The selenylation of mCVP-1S, performed using an HNO3-Na2SeO3 method, produced a series of selenized mCVP-1Ss (SemCVP-1Ss). Varying the reaction time, temperature and Na2SeO3 dosage altered the yield and selenium content of the SemCVP-1Ss. NMR spectra showed substitution mostly at C-6, and Congo red tests indicated excessive selenylation might destroy the triple-helical structure of SemCVP-1Ss...
October 15, 2017: Carbohydrate Polymers
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