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https://www.readbyqxmd.com/read/28819115/genome-wide-identification-and-expression-profiling-of-long-non-coding-rnas-in-auditory-and-vestibular-systems
#1
Kathy Ushakov, Tal Koffler-Brill, Aviv Rom, Kobi Perl, Igor Ulitsky, Karen B Avraham
Mammalian genomes encode multiple layers of regulation, including a class of RNA molecules known as long non-coding RNAs (lncRNAs). These are >200 nucleotides in length and similar to mRNAs, they are capped, polyadenylated, and spliced. In contrast to mRNAs, lncRNAs are less abundant and have higher tissue specificity, and have been linked to development, epigenetic processes, and disease. However, little is known about lncRNA function in the auditory and vestibular systems, or how they play a role in deafness and vestibular dysfunction...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818455/adipose-derived-stromal-cells-enhance-auditory-neuron-survival-in-an-animal-model-of-sensory-hearing-loss
#2
Philipp Schendzielorz, Maike Vollmer, Kristen Rak, Armin Wiegner, Nashwa Nada, Katrin Radeloff, Rudolf Hagen, Andreas Radeloff
BACKGROUND: A cochlear implant (CI) is an electronic prosthesis that can partially restore speech perception capabilities. Optimum information transfer from the cochlea to the central auditory system requires a proper functioning auditory nerve (AN) that is electrically stimulated by the device. In deafness, the lack of neurotrophic support, normally provided by the sensory cells of the inner ear, however, leads to gradual degeneration of auditory neurons with undesirable consequences for CI performance...
August 14, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28817718/elevated-carboxylesterase-activity-contributes-to-the-lambda-cyhalothrin-insensitivity-in-quercetin-fed-helicoverpa-armigera-h%C3%A3-bner
#3
Chengyu Chen, Ying Liu, Xueyan Shi, Nicolas Desneux, Peng Han, Xiwu Gao
Quercetin as one of the key plant secondary metabolite flavonol is ubiquitous in terrestrial plants. In this study, the decrease in sensitivity to lambda-cyhalothrin was observed in quercetin-fed Helicoverpa armigera larvae. In order to figure out the mechanisms underlying the decreased sensitivity of H. armigera larvae to lambda-cyhalothrin by quercetin induction, the changes in carboxylesterase activity and in-vitro hydrolytic metabolic capacity to lambda-cyhalothrin were examined. The LC50 value of quercetin-fed H...
2017: PloS One
https://www.readbyqxmd.com/read/28815995/progressive-macrothrombocytopenia-and-hearing-loss-in-a-large-family-with-diaph1-related-disease
#4
Akira Ganaha, Tadashi Kaname, Ayano Shinjou, Yasutsugu Chinen, Kumiko Yanagi, Teruyuki Higa, Shunsuke Kondo, Mikio Suzuki
In this study, we describe a Japanese family with progressive hearing loss and macrothrombocytopenia. Using next-generation and Sanger sequencing analyses, we identified a heterozygous variant in exon 27 of the DIAPH1 gene (NM_005219), c.3637C>T, p.R1213X. All patients in the family had sensorineural hearing loss and macrothrombocytopenia. None of the patients exhibited a tendency to bleed. No pathogenic variants were found in the MYH9 gene. Hearing loss began with high-frequency loss during early childhood and progressed to severe hearing loss involving all frequencies...
August 16, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28815950/ribosome-profiling-a-hi-def-monitor-for-protein-synthesis-at-the-genome-wide-scale
#5
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/28814566/neurodevelopmental-outcome-at-2-years-for-preterm-children-born-at-22-to-34-weeks-gestation-in-france-in-2011-epipage-2-cohort-study
#6
Véronique Pierrat, Laetitia Marchand-Martin, Catherine Arnaud, Monique Kaminski, Matthieu Resche-Rigon, Cécile Lebeaux, Florence Bodeau-Livinec, Andrei S Morgan, François Goffinet, Stéphane Marret, Pierre-Yves Ancel
Objectives To describe neurodevelopmental outcomes at 2 years corrected age for children born alive at 22-26, 27-31, and 32-34 weeks' gestation in 2011, and to evaluate changes since 1997.Design Population based cohort studies, EPIPAGE and EPIPAGE-2.Setting France.Participants 5567 neonates born alive in 2011 at 22-34 completed weeks' gestation, with 4199 survivors at 2 years corrected age included in follow-up. Comparison of outcomes reported for 3334 (1997) and 2418 (2011) neonates born alive in the nine regions participating in both studies...
August 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28814550/changing-neurodevelopment-at-8-years-in-children-born-extremely-preterm-since-the-1990s
#7
Jeanie L Y Cheong, Peter J Anderson, Alice C Burnett, Gehan Roberts, Noni Davis, Leah Hickey, Elizabeth Carse, Lex W Doyle
BACKGROUND AND OBJECTIVE: Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 years of age of children born EP (22-27 completed weeks' gestation) over the past 2 decades. METHODS: Population-based cohorts of all EP survivors born in the state of Victoria, Australia in 1991-1992, 1997, and 2005 were recruited at birth...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28811558/cross-modal-plasticity-in-the-deaf-enhances-processing-of-masked-stimuli-in-the-visual-modality
#8
Seema Prasad, Gouri Shanker Patil, Ramesh Kumar Mishra
Compensatory changes as a result of auditory deprivation in the deaf lead to higher visual processing skills. In two experiments, we explored if such brain plasticity in the deaf modulates processing of masked stimuli in the visual modality. Deaf and normal-hearing participants responded to targets either voluntarily or by instruction. Masked primes related to the response were presented briefly before the targets at the center and the periphery. In Experiment 1, targets appeared only at the foveal region whereas, in Experiment 2, they appeared both at the fovea and the periphery...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810498/late-emotional-effects-of-rehabilitation-during-childhood-and-their-impact-on-coping-with-deafness-in-adulthood
#9
Adva Eichengreen, Dan Hoofien
This study examined potential influences of childhood rehabilitation and over-normalization on coping with disability in adulthood. A total of 88 deaf and hard-of-hearing students were interviewed retrospectively about their childhood and completed self-report questionnaires assessing psychological environment-directedness and present emotional and behavioral coping with deafness. It was partially supported that over-normative parental attitude negatively affected coping with deafness through the mediation of elevated environment-directedness...
July 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28808014/adaptive-benefit-of-cross-modal-plasticity-following-cochlear-implantation-in-deaf-adults
#10
Carly A Anderson, Ian M Wiggins, Pádraig T Kitterick, Douglas E H Hartley
It has been suggested that visual language is maladaptive for hearing restoration with a cochlear implant (CI) due to cross-modal recruitment of auditory brain regions. Rehabilitative guidelines therefore discourage the use of visual language. However, neuroscientific understanding of cross-modal plasticity following cochlear implantation has been restricted due to incompatibility between established neuroimaging techniques and the surgically implanted electronic and magnetic components of the CI. As a solution to this problem, here we used functional near-infrared spectroscopy (fNIRS), a noninvasive optical neuroimaging method that is fully compatible with a CI and safe for repeated testing...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807077/cochlear-implantation-in-malawi-report-of-the-first-four-cases
#11
W Mulwafu, D R Strachan, R Bartlett, C Caron
OBJECTIVE: This paper reports on the first four cochlear implant cases in Malawi. CASE REPORTS: Three patients were deafened from infectious diseases and one from an unknown cause. They all had post-lingual deafness. Six months after the last implant, they are all progressing well. CONCLUSION: Despite significant practical difficulties, it has proved possible, with the right support, to carry out cochlear implantation in one of the world's poorest countries...
August 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28806342/cognitive-abilities-and-quality-of-life-after-cochlear-implantation-in-the-elderly
#12
Marie-Hortense Sonnet, Bettina Montaut-Verient, Jean-Yves Niemier, Michel Hoen, Laurence Ribeyre, Cécile Parietti-Winkler
OBJECTIVE: To evaluate quality of life (QoL) and cognitive function in elderly patients with cochlear implants relative to auditory improvement, using geriatric validated scales. STUDY DESIGN: Prospective observational study. SETTING: A tertiary referral center for cochlear implantation (CI) and a geriatric center in Nancy, France. PATIENTS: Sixteen consecutive patients were included, from 65 to 80 years old, with postlingual severe-to-profound deafness...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806338/isolated-second-implant-adaptation-period-in-sequential-cochlear-implantation-in-adults
#13
Kari Smilsky, Peter R Dixon, Leah Smith, David Shipp, Amy Ng, Tara Millman, Suzanne Stewart, Julian M Nedzelski, Vincent Y Lin, Joseph M Chen
OBJECTIVE: To determine if depriving the use of the first cochlear implant (CI1) impacts adaptation to a sequential implant (CI2). STUDY DESIGN: Prospective cohort. SETTING: Academic center. PATIENTS: Sixteen unilateral cochlear implant recipients undergoing contralateral implantation (sequential bilateral) were matched according to age, etiology, duration of deafness, device age, and delay between implants. INTERVENTION: During a 4-week adaptation period after CI2 activation, patients underwent deprivation of CI1 or were permitted continued use of it...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806337/the-sound-quality-of-cochlear-implants-studies-with-single-sided-deaf-patients
#14
Michael F Dorman, Sarah Cook Natale, Austin M Butts, Daniel M Zeitler, Matthew L Carlson
OBJECTIVE: The goal of the present study was to assess the sound quality of a cochlear implant for single-sided deaf (SSD) patients fit with a cochlear implant (CI). BACKGROUND: One of the fundamental, unanswered questions in CI research is "what does an implant sound like?" Conventional CI patients must use the memory of a clean signal, often decades old, to judge the sound quality of their CIs. In contrast, SSD-CI patients can rate the similarity of a clean signal presented to the CI ear and candidate, CI-like signals presented to the ear with normal hearing...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806335/a-smartphone-application-for-customized-frequency-table-selection-in-cochlear-implants
#15
Daniel Jethanamest, Mahan Azadpour, Annette M Zeman, Elad Sagi, Mario A Svirsky
HYPOTHESIS: A novel smartphone-based software application can facilitate self-selection of frequency allocation tables (FAT) in postlingually deaf cochlear implant (CI) users. BACKGROUND: CIs use FATs to represent the tonotopic organization of a normal cochlea. Current CI fitting methods typically use a standard FAT for all patients regardless of individual differences in cochlear size and electrode location. In postlingually deaf patients, different amounts of mismatch can result between the frequency-place function they experienced when they had normal hearing and the frequency-place function that results from the standard FAT...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806334/cochlear-implantation-in-postlingual-adult-patients-with-long-term-auditory-deprivation
#16
Maria Del Mar Medina, Ruben Polo, Auxiliadora Gutierrez, Alfonso Muriel, Miguel Vaca, Cecilia Perez, Adela Cordero, Ignacio Cobeta
OBJECTIVE: The role of long-term hearing deprivation in cochlear implant performance is not well established, and the limits for implanting an auditory deprived ear are still unknown. The objective of this study was to evaluate the effect of long-term auditory deprivation time on cochlear implant results. STUDY DESIGN: Retrospective case review study. SETTING: Cochlear implantation tertiary referral center. PATIENTS: Adult patients with postlingual deafness...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806332/linking-deafness-and-dementia-challenges-and-opportunities
#17
Vincent Y W Lin, Sandra E Black
: The rising incidence of dementia locally and worldwide has now reached a critical level. The associated costs associated with these individuals will ultimately be untenable to most societies. Furthermore there is a paucity of highly effective treatments. However, the recent discovery of the association of hearing loss and dementia may open many potential opportunities. Although we still are acquiring knowledge on the pathophysiology of this association, clinicians are hopeful that our current highly effective treatments of hearing loss may ultimately be shown to have a positive effect on those with dementia...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806330/nanoci-nanotechnology-based-cochlear-implant-with-gapless-interface-to-auditory-neurons
#18
Pascal Senn, Marta Roccio, Stefan Hahnewald, Claudia Frick, Monika Kwiatkowska, Masaaki Ishikawa, Peter Bako, Hao Li, Fredrik Edin, Wei Liu, Helge Rask-Andersen, Ilmari Pyykkö, Jing Zou, Marika Mannerström, Herbert Keppner, Alexandra Homsy, Edith Laux, Miguel Llera, Jean-Paul Lellouche, Stella Ostrovsky, Ehud Banin, Aharon Gedanken, Nina Perkas, Ute Wank, Karl-Heinz Wiesmüller, Pavel Mistrík, Heval Benav, Carolyn Garnham, Claude Jolly, Filippo Gander, Peter Ulrich, Marcus Müller, Hubert Löwenheim
: Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence sub-optimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible for significant battery costs and for impeding the development of fully implantable systems)...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806329/physiological-mechanisms-in-combined-electric-acoustic-stimulation
#19
Mika Sato, Peter Baumhoff, Jochen Tillein, Andrej Kral
OBJECTIVE: Electrical stimulation is normally performed on ears that have no hearing function, i.e., lack functional hair cells. The properties of electrically-evoked responses in these cochleae were investigated in several previous studies. Recent clinical developments have introduced cochlear implantation (CI) in residually-hearing ears to improve speech understanding in noise. The present study documents the known physiological differences between electrical stimulation of hair cells and of spiral ganglion cells, respectively, and reviews the mechanisms of combined electric and acoustic stimulation in the hearing ears...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28805146/deafness-and-hearing-aids-in-low-and-middle-income-countries
#20
Bradley McPherson
No abstract text is available yet for this article.
August 14, 2017: Paediatrics and International Child Health
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